Original Article Galectin-1 and DNMT1 Are Highly Expressed and Related to the Prognoses of Patients with Cervical Cancer
Int J Clin Exp Med 2020;13(3):1439-1446 www.ijcem.com /ISSN:1940-5901/IJCEM0103882 Original Article Galectin-1 and DNMT1 are highly expressed and related to the prognoses of patients with cervical cancer Xiaomin Guo1, Chunyan Yang2, Hongying Zhao3, Xingjun Wu4, Yanling Dai5 1School of Nursing, Chuxiong Medical and Pharmaceutical College, Chuxiong City, Yunnan Province, China; 2Department of Pharmacy, Chuxiong Medical and Pharmaceutical College, Chuxiong City, Yunnan Province, China; 3Department of Tumor and Hematology, The First People’s Hospital, Honghe Prefecture, Mengzi City, Yunnan Province, China; 4Qujing Medical College, Qujing City, Yunnan Province, China; 5Department of Laboratory, Chuxiong Medical and Pharmaceutical College, Chuxiong City, Yunnan Province, China Received October 23, 2019; Accepted November 21, 2019; Epub March 15, 2020; Published March 30, 2020 Abstract: Objective: To explore the expressions of galectin-1 and human DNA methyltransferase 1 (DNMT1) in cervical cancer tissues and normal cervical tissues and their clinical significance. Method: Eighty-four patients with cervical cancer were randomly selected. 84 samples of cancer tissues and their para-carcinoma tissues were ana- lyzed with regard to the following parameters: Galectin-1 and DNMT1 mRNA analyzed by RT-PCR, and galectin-1 and DNMT1 protein by western blotting. The relationships between the expressions of galectin-1 and DNMT1 protein, the clinicopathological factors, and the prognoses were analyzed. A correlation analysis was performed between the galectin-1 and DNMT1 protein expressions in the cervical cancer tissues. Result: The expressions of galectin-1 and DNMT1 mRNA and protein in the cervical cancer tissues were higher than they were in the para-carcinoma tis- sues (P<0.05).
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