GSK – 50 years of R&D innovation

Medicines Seretide/ Ventolin Augmentin Retrovir Advair Votrient Tivicay Triumeq Asthma Bacterial infections HIV/AIDS Asthma (COPD) Renal cell carcinoma HIV/AIDS HIV/AIDS 1969 1981 1987 1998 (2003) 2010 2013 2014

Amoxil Zantac Seroxat/Paxil Trizivir Relvar/ Anoro Ellipta Mekinist Bacterial infections Stomach ulcers Depression, various HIV/AIDS Breo Ellipta COPD BRAF V600+ 1972 1981 anxiety disorders 2000 COPD and asthma 2014 metastatic melanoma 1991 2013 2014

Vaccines Boostrix Infanrix hexa Fluarix/ Diphtheria, tetanus, Diphtheria, tetanus, pertussis, Cervarix Priorix-Tetra pertussis. Booster Haemophilus influenzae type B, Human papilloma Measles, mumps, rubella, FluLaval Tetra Priorix Havrix Seasonal flu Measles, mumps, rubella Hepatitis A vaccination polio and hepatitis B virus type 16 and 18 varicella (chickenpox) 2012 (quadrivalent, 4 strains) 1970 1992 1994 2000 2007 2013

Engerix B Fluarix/FluLaval Twinrix Rotarix Synflorix Nimenrix Hepatitis B Seasonal flu (3 strains) Hepatitis A and B Rotavirus Invasive pneumococcal Meningitis ACWY 1986 1992 1996 2005 disease, pneumonia 2012 acute otitis media 2009

Consumer Healthcare products Sensodyne Panadol Actifast Panadol Advance Repair & Protect Zovirax Duo Oral health Pain relief Pain relief Oral health Skin health 1961 2001 2008 2011 2014

Aquafresh Triple Action Sensodyne Women’s Fenbid Chewable Flonase/Flixonase Oral health Pronamel Pain relief Allergic rhinitis 1981 Oral health Health drink 2014 2015 2006 2008

1961 2015

Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis. GSK – 50 years of R&D innovation

Medicines

Product name Generic name Indication Date of Product name Generic name Indication Date of first launch first launch

Ventolin sulphate Asthma 1969 Seretide/Advair salmeterol xinafoate and COPD 2003 propionate Amoxil Bacterial infections 1972 Hycamtin topotecan Small cell lung cancer 2007 Becotide/ beclomethasone Asthma 1972 Beclovent dipropionate Tykerb/Tyverb lapatanib Advanced and metastatic breast 2007 cancer in HER2 positive patients Beconase beclomethasone Allergic rhinitis 1975 dipropionate Avamys/Veramyst Allergic rhinitis 2008

Tagamet Stomach ulcers 1976 Votrient pazopanib Renal cell carcinoma 2009

Augmentin co-amoxiclav Bacterial infections 1981 Benlysta belimumab Systemic lupus erythematosus 2011

Zovirax Herpes infections 1981 Votrient pazopanib Soft tissue sarcoma metastatic 2013

Zantac hydrochloride Stomach ulcers 1981 Relvar/Breo fluticasone furoate and Asthma and COPD 2013 Ellipta vilanterol terfenatate Wellbutrin Depression 1982 Tivicay dolutegravir HIV/AIDS 2013 Retrovir HIV/AIDS 1987 Anoro Ellipta umeclidinium bromide and COPD 2014 Imigran Migraine 1990 vilanterol terfenatate

Serevent salmeterol xinafoate Asthma 1990 Incruse Ellipta umeclidinium bromide COPD 2014

Seroxat/Paxil Depression, various anxiety disorders 1991 Arnuity Ellipta fluticasone furoate Asthma 2014

Zofran hydrochloride Post operative or chemotherapy 1991 Triumeq , dolutegravir, HIV/AIDS 2014 induced nausea

Lamictal Epilepsy, bipolar disorder 1990 Mekinist trametinib BRAF V600+ metastatic melanoma 2014

Requip Parkinson’s disease 1996 Tafinlar dabrafenib BRAF V600+ metastatic melanoma 2014

Seretide/Advair salmeterol xinafoate and Asthma 1998 fluticasone propionate

Avandia Type 2 diabetes 1999

Trizivir abacavir, lamivudine, HIV/AIDS 2000 zidovudine

Avodart Benign prostatic hyperplasia 2001

Kivexa abacavir, lamivudine HIV/AIDS 2004

Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis. GSK – 50 years of R&D innovation

Vaccines Product name Indication Date of Product name Indication Date of first launch first launch

Poliorix Polio 1956 Synflorix Invasive pneumococcal disease, pneumonia acute 2009 otitis media Cendevax Rubella 1969 Arepanrix Pandemic flu (H1N1) 2010 Priorix Measles, mumps, rubella 1970 MenHibrix Meningitis C, Y and Haemophilus influenzae type B 2012 Varilrix Varicella (chickenpox) 1984 Priorix Tetra Measles, mumps, rubella, varicella (chickenpox) 2012 Engerix B Hepatitis B 1986 Nimenrix Meningitis ACWY 2012 Havrix Hepatitis A 1992 Fluarix/FluLaval Tetra Seasonal flu (quadrivalent, 4 strains) 2013 Fluarix/FluLaval Seasonal flu (trivalent, 3 strains) 1992

Boostrix Diphtheria, tetanus, pertussis. Booster vaccination 1994

Twinrix Hepatitis A and B 1996

Tritanrix HepB/Hib Diphtheria, tetanus, pertussis, hepatitis B, with and 1996 without Haemophilus influenzae type B

Infanrix Hib Diphtheria, tetanus, pertussis, Haemophilus influenzae 1997 type B

Infanrix Polio Diphtheria, tetanus, pertussis, polio 1997

Typherix Typhoid fever 1998

Hepatyrix Hepatitis A and typhoid fever 1999

Infanrix hexa Diphtheria, tetanus, pertussis, Haemophilus influenzae 2000 type B, polio and hepatitis B

Mencevax Meningitis ACW 2003

Rotarix Rotavirus 2005

Fendrix Hepatitis B 2005

Menitorix Meningitis C and Haemophilus influenzae type B 2006

Cervarix Human papilloma virus type 16 and 18 2007

Pandemrix/Pre- Pandemic flu (H5N1) 2008

Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis. GSK – 50 years of R&D innovation

Consumer Healthcare products

Product name Indication / use Date of Product name Indication / use Date of first launch first launch

Sensodyne Oral health 1961 Fenbid Chewable Pain relief 2014

Aquafresh Oral health 1973 Zovirax Duo Skin health 2014

Aquafresh Triple Action Oral health 1981 Sensodyne Mouthwash Oral health 2015

Aquafresh Kids Oral Health 1985 Flonase/Flixonase Allergic rhinitis 2015

Poligrip Ultra Hold Oral health 1990

Nicorette Smokers health 1996

NicoDerm CQ SmartControl Technology Smokers health 1997 Clear Patch

Aquafresh Flex Toothbrush Oral health 1998

Physiogel BioMimic Technology Skin health 2000

Panadol Actifast Pain relief 2001

Abbreva Skin health 2002

Sensodyne Pronamel Oral health 2006

Panadol Extended Release Pain relief 2006

Panadol Advance Optizorb Technology Pain relief 2008

Women’s Horlicks Micronutrients for women Health drink 2008

Sensodyne Repair & Protect With Novamin Oral health 2011

Panadol Extra Optizorb Technology Pain relief 2011

NiQuitin Strips Smokers health 2013

Aquafresh Complete Care Oral health 2013 Mouthwash

Aquafresh Complete Care Oral health 2014

Sensodyne True White True White Technology Oral health 2014

Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis.