GSK – 50 years of R&D innovation Medicines Seretide/ Ventolin Augmentin Retrovir Advair Votrient Tivicay Triumeq Asthma Bacterial infections HIV/AIDS Asthma (COPD) Renal cell carcinoma HIV/AIDS HIV/AIDS 1969 1981 1987 1998 (2003) 2010 2013 2014 Amoxil Zantac Seroxat/Paxil Trizivir Relvar/ Anoro Ellipta Mekinist Bacterial infections Stomach ulcers Depression, various HIV/AIDS Breo Ellipta COPD BRAF V600+ 1972 1981 anxiety disorders 2000 COPD and asthma 2014 metastatic melanoma 1991 2013 2014 Vaccines Boostrix Infanrix hexa Fluarix/ Diphtheria, tetanus, Diphtheria, tetanus, pertussis, Cervarix Priorix-Tetra pertussis. Booster Haemophilus influenzae type B, Human papilloma Measles, mumps, rubella, FluLaval Tetra Priorix Havrix Seasonal flu Measles, mumps, rubella Hepatitis A vaccination polio and hepatitis B virus type 16 and 18 varicella (chickenpox) 2012 (quadrivalent, 4 strains) 1970 1992 1994 2000 2007 2013 Engerix B Fluarix/FluLaval Twinrix Rotarix Synflorix Nimenrix Hepatitis B Seasonal flu (3 strains) Hepatitis A and B Rotavirus Invasive pneumococcal Meningitis ACWY 1986 1992 1996 2005 disease, pneumonia 2012 acute otitis media 2009 Consumer Healthcare products Sensodyne Sensodyne Panadol Actifast Panadol Advance Repair & Protect Zovirax Duo Oral health Pain relief Pain relief Oral health Skin health 1961 2001 2008 2011 2014 Aquafresh Triple Action Sensodyne Women’s Fenbid Chewable Flonase/Flixonase Oral health Pronamel Horlicks Pain relief Allergic rhinitis 1981 Oral health Health drink 2014 2015 2006 2008 1961 2015 Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis. GSK – 50 years of R&D innovation Medicines Product name Generic name Indication Date of Product name Generic name Indication Date of first launch first launch Ventolin salbutamol sulphate Asthma 1969 Seretide/Advair salmeterol xinafoate and COPD 2003 fluticasone propionate Amoxil amoxicillin Bacterial infections 1972 Hycamtin topotecan Small cell lung cancer 2007 Becotide/ beclomethasone Asthma 1972 Beclovent dipropionate Tykerb/Tyverb lapatanib Advanced and metastatic breast 2007 cancer in HER2 positive patients Beconase beclomethasone Allergic rhinitis 1975 dipropionate Avamys/Veramyst fluticasone furoate Allergic rhinitis 2008 Tagamet cimetidine Stomach ulcers 1976 Votrient pazopanib Renal cell carcinoma 2009 Augmentin co-amoxiclav Bacterial infections 1981 Benlysta belimumab Systemic lupus erythematosus 2011 Zovirax aciclovir Herpes infections 1981 Votrient pazopanib Soft tissue sarcoma metastatic 2013 Zantac ranitidine hydrochloride Stomach ulcers 1981 Relvar/Breo fluticasone furoate and Asthma and COPD 2013 Ellipta vilanterol terfenatate Wellbutrin bupropion Depression 1982 Tivicay dolutegravir HIV/AIDS 2013 Retrovir zidovudine HIV/AIDS 1987 Anoro Ellipta umeclidinium bromide and COPD 2014 Imigran sumatriptan Migraine 1990 vilanterol terfenatate Serevent salmeterol xinafoate Asthma 1990 Incruse Ellipta umeclidinium bromide COPD 2014 Seroxat/Paxil paroxetine Depression, various anxiety disorders 1991 Arnuity Ellipta fluticasone furoate Asthma 2014 Zofran ondansetron hydrochloride Post operative or chemotherapy 1991 Triumeq abacavir, dolutegravir, HIV/AIDS 2014 induced nausea lamivudine Lamictal lamotrigine Epilepsy, bipolar disorder 1990 Mekinist trametinib BRAF V600+ metastatic melanoma 2014 Requip ropinirole Parkinson’s disease 1996 Tafinlar dabrafenib BRAF V600+ metastatic melanoma 2014 Seretide/Advair salmeterol xinafoate and Asthma 1998 fluticasone propionate Avandia rosiglitazone Type 2 diabetes 1999 Trizivir abacavir, lamivudine, HIV/AIDS 2000 zidovudine Avodart dutasteride Benign prostatic hyperplasia 2001 Kivexa abacavir, lamivudine HIV/AIDS 2004 Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis. GSK – 50 years of R&D innovation Vaccines Product name Indication Date of Product name Indication Date of first launch first launch Poliorix Polio 1956 Synflorix Invasive pneumococcal disease, pneumonia acute 2009 otitis media Cendevax Rubella 1969 Arepanrix Pandemic flu (H1N1) 2010 Priorix Measles, mumps, rubella 1970 MenHibrix Meningitis C, Y and Haemophilus influenzae type B 2012 Varilrix Varicella (chickenpox) 1984 Priorix Tetra Measles, mumps, rubella, varicella (chickenpox) 2012 Engerix B Hepatitis B 1986 Nimenrix Meningitis ACWY 2012 Havrix Hepatitis A 1992 Fluarix/FluLaval Tetra Seasonal flu (quadrivalent, 4 strains) 2013 Fluarix/FluLaval Seasonal flu (trivalent, 3 strains) 1992 Boostrix Diphtheria, tetanus, pertussis. Booster vaccination 1994 Twinrix Hepatitis A and B 1996 Tritanrix HepB/Hib Diphtheria, tetanus, pertussis, hepatitis B, with and 1996 without Haemophilus influenzae type B Infanrix Hib Diphtheria, tetanus, pertussis, Haemophilus influenzae 1997 type B Infanrix Polio Diphtheria, tetanus, pertussis, polio 1997 Typherix Typhoid fever 1998 Hepatyrix Hepatitis A and typhoid fever 1999 Infanrix hexa Diphtheria, tetanus, pertussis, Haemophilus influenzae 2000 type B, polio and hepatitis B Mencevax Meningitis ACW 2003 Rotarix Rotavirus 2005 Fendrix Hepatitis B 2005 Menitorix Meningitis C and Haemophilus influenzae type B 2006 Cervarix Human papilloma virus type 16 and 18 2007 Pandemrix/Pre-pandemrix Pandemic flu (H5N1) 2008 Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis. GSK – 50 years of R&D innovation Consumer Healthcare products Product name Indication / use Date of Product name Indication / use Date of first launch first launch Sensodyne Oral health 1961 Fenbid Chewable Pain relief 2014 Aquafresh Oral health 1973 Zovirax Duo Skin health 2014 Aquafresh Triple Action Oral health 1981 Sensodyne Mouthwash Oral health 2015 Aquafresh Kids Oral Health 1985 Flonase/Flixonase Allergic rhinitis 2015 Poligrip Ultra Hold Oral health 1990 Nicorette Smokers health 1996 NicoDerm CQ SmartControl Technology Smokers health 1997 NiQuitin Clear Patch Aquafresh Flex Toothbrush Oral health 1998 Physiogel BioMimic Technology Skin health 2000 Panadol Actifast Pain relief 2001 Abbreva Skin health 2002 Sensodyne Pronamel Oral health 2006 Panadol Extended Release Pain relief 2006 Panadol Advance Optizorb Technology Pain relief 2008 Women’s Horlicks Micronutrients for women Health drink 2008 Sensodyne Repair & Protect With Novamin Oral health 2011 Panadol Extra Optizorb Technology Pain relief 2011 NiQuitin Strips Smokers health 2013 Aquafresh Complete Care Oral health 2013 Mouthwash Aquafresh Complete Care Oral health 2014 Sensodyne True White True White Technology Oral health 2014 Not all products are still owned, produced or marketed by GSK. Excludes products now owned by GSK through the recent transaction with Novartis..