Table 1 to Subpart Yyy—List of Socmi Chemicals
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A Guide to Export Controls
Foreign Affairs, Trade and Affaires étrangères, Commerce et Development Canada Développment Canada A Guide To CANADA’S EXPORT CONTROLS December 2012 Introduction The issuance of export permits is administered by the Export Controls Division (TIE) of Foreign Affairs, Trade and Development Canada (DFATD). TIE provides assistance to exporters in determining if export permits are required. It also publishes brochures and Notices to Exporters that are freely available on request and on our website www.exportcontrols.gc.ca. How to contact us: Export Controls Division (TIE) Foreign Affairs, Trade and Development Canada 111 Sussex Drive Ottawa, Ontario K1A 0G2 Telephone: (613) 996-2387 Facsimile: (613) 996-9933 Email: [email protected] For information on how to apply for an export permit and additional information on export controls please refer to our website. To enquire on the status of an export permit application: Recognized EXCOL users can check the status of an export permit application on-line. Non-recognized users can call (613) 996-2387 or email [email protected] and quote your export permit application identification (ref ID) number. Export Controls Division website: www.exportcontrols.gc.ca This Guide, at time of publication, encompasses the list of items enumerated on the Export Control List (ECL) that are controlled for export in accordance with Canadian foreign policy, including Canada’s participation in multilateral export control regimes and bilateral agreements. Unless otherwise specified, the export controls contained in this Guide apply to all destinations except the United States. Canada’s Export Control List can be found at the Department of Justice website at http://canada.justice.gc.ca/. -
Of 10 October 2018 Amending Council Regulation (EC) No 428/2009
14.12.2018 EN Official Journal of the European Union L 319/1 II (Non-legislative acts) REGULATIONS COMMISSION DELEGATED REGULATION (EU) 2018/1922 of 10 October 2018 amending Council Regulation (EC) No 428/2009 setting up a Community regime for the control of exports, transfer, brokering and transit of dual-use items THE EUROPEAN COMMISSION, Having regard to the Treaty on the Functioning of the European Union, Having regard to Council Regulation (EC) No 428/2009 of 5 May 2009 setting up a Community regime for the control of exports, transfer, brokering and transit of dual-use items ( 1), and in particular Article 15(3) thereof, Whereas: (1) Regulation (EC) No 428/2009 requires dual-use items to be subject to effective control when they are exported from or transit through the Union, or are delivered to a third country as a result of brokering services provided by a broker resident or established in the Union. (2) Annex I to Regulation (EC) No 428/2009 establishes the common list of dual-use items that are subject to controls in the Union. Decisions on the items subject to controls are taken within the framework of the Australia Group ( 2 ), the Missile Technology Control Regime ( 3 ), the Nuclear Suppliers Group ( 4 ), the Wassenaar Arrangement ( 5 ) and the Chemical Weapons Convention. (3) The list of dual-use items set out in Annex I to Regulation (EC) No 428/2009 needs to be updated regularly so as to ensure full compliance with international security obligations, to guarantee transparency, and to maintain the competitiveness of economic operators. -
02/06/2019 12:05 PM Appendix 3745-21-09 Appendix A
ACTION: Final EXISTING DATE: 02/06/2019 12:05 PM Appendix 3745-21-09 Appendix A List of Organic Chemicals for which Paragraphs (DD) and (EE) of Rule 3745-21-09 of the Administrative Code are Applicable Organic Chemical Organic Chemical Acetal Benzaldehyde Acetaldehyde Benzamide Acetaldol Benzene Acetamide Benzenedisulfonic acid Acetanilide Benzenesulfonic acid Acetic acid Benzil Acetic Anhydride Benzilic acid Acetone Benzoic acid Acetone cyanohydrin Benzoin Acetonitrile Benzonitrile Acetophenone Benzophenone Acetyl chloride Benzotrichloride Acetylene Benzoyl chloride Acrolein Benzyl alcohol Acrylamide Benzylamine Acrylic acid Benzyl benzoate Acrylonitrile Benzyl chloride Adipic acid Benzyl dichloride Adiponitrile Biphenyl Alkyl naphthalenes Bisphenol A Allyl alcohol Bromobenzene Allyl chloride Bromonaphthalene Aminobenzoic acid Butadiene Aminoethylethanolamine 1-butene p-aminophenol n-butyl acetate Amyl acetates n-butyl acrylate Amyl alcohols n-butyl alcohol Amyl amine s-butyl alcohol Amyl chloride t-butyl alcohol Amyl mercaptans n-butylamine Amyl phenol s-butylamine Aniline t-butylamine Aniline hydrochloride p-tertbutyl benzoic acid Anisidine 1,3-butylene glycol Anisole n-butyraldehyde Anthranilic acid Butyric acid Anthraquinone Butyric anhydride Butyronitrile Caprolactam APPENDIX p(183930) pa(324943) d: (715700) ra(553210) print date: 02/06/2019 12:05 PM 3745-21-09, Appendix A 2 Carbon disulfide Cyclohexene Carbon tetrabromide Cyclohexylamine Carbon tetrachloride Cyclooctadiene Cellulose acetate Decanol Chloroacetic acid Diacetone alcohol -
Agrimer™ Polyvinylpyyrolidone (PVP)
agrimer ™ polyvinylpyyrolidone (PVP) binder, dispersant rheology, modifier, film former, complexing agent Agrimer™ polyvinylpyrrolidone (PVP) this brochure is divided into two main segments suggested applications General properties and uses 2-10 ¢ complexing agent Agricultural case studies 10 ¢ stabilizers / co-dispersants These case studies highlight the uses of Agrimer™ ¢ binders in dry / wet granulation and extrusion (dry compaction / fluidized-bed spray drying process) polymers in seed coatings, granule and tablet binders and as dispersants. ¢ film-forming agents / binders in seed coatings, dips and pour-ons general properties and uses ¢ biological stabilization ¢ water binding / anti-transpiration properties Agrimer™ PVP products are linear, non-ionic polymers that are soluble in water and many organic solvents. ¢ solubility enhancers via co-precipitation or They are pH stable, and have adhesive, cohesive thermal extrusion and binding properties. The unique ability to adsorb ¢ dye-binding agent on a host of active ingredients makes Agrimer™ PVP regulatory status homopolymers preferred co-dispersants in many The Agrimer™ PVP products listed in this brochure are formulations. Agrimer™ homopolymers have a high exempt from the requirement of a tolerance under glass transition temperature. 40 CFR 180.960. Lower molecular weight (Mw) Agrimer™ polymers (Agrimer™ 15 and Agrimer™ 30) are suitable for physical and chemical properties applications where dusting is a concern, such as The Agrimer™ polymers, a family of homopolymers of seed coatings and agglomeration. Higher Mw polyvinylpyrrolidone, are available in different viscosity Agrimer™ polymers (Agrimer™ 90 and Agrimer™ 120) can grades, ranging from very low to very high molecular build formulation viscosity faster and provide excellent weight. This range, coupled with their solubility in binding and film forming properties. -
Euthanasia of Experimental Animals
EUTHANASIA OF EXPERIMENTAL ANIMALS • *• • • • • • • *•* EUROPEAN 1COMMISSIO N This document has been prepared for use within the Commission. It does not necessarily represent the Commission's official position. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server (http://europa.eu.int) Cataloguing data can be found at the end of this publication Luxembourg: Office for Official Publications of the European Communities, 1997 ISBN 92-827-9694-9 © European Communities, 1997 Reproduction is authorized, except for commercial purposes, provided the source is acknowledged Printed in Belgium European Commission EUTHANASIA OF EXPERIMENTAL ANIMALS Document EUTHANASIA OF EXPERIMENTAL ANIMALS Report prepared for the European Commission by Mrs Bryony Close Dr Keith Banister Dr Vera Baumans Dr Eva-Maria Bernoth Dr Niall Bromage Dr John Bunyan Professor Dr Wolff Erhardt Professor Paul Flecknell Dr Neville Gregory Professor Dr Hansjoachim Hackbarth Professor David Morton Mr Clifford Warwick EUTHANASIA OF EXPERIMENTAL ANIMALS CONTENTS Page Preface 1 Acknowledgements 2 1. Introduction 3 1.1 Objectives of euthanasia 3 1.2 Definition of terms 3 1.3 Signs of pain and distress 4 1.4 Recognition and confirmation of death 5 1.5 Personnel and training 5 1.6 Handling and restraint 6 1.7 Equipment 6 1.8 Carcass and waste disposal 6 2. General comments on methods of euthanasia 7 2.1 Acceptable methods of euthanasia 7 2.2 Methods acceptable for unconscious animals 15 2.3 Methods that are not acceptable for euthanasia 16 3. Methods of euthanasia for each species group 21 3.1 Fish 21 3.2 Amphibians 27 3.3 Reptiles 31 3.4 Birds 35 3.5 Rodents 41 3.6 Rabbits 47 3.7 Carnivores - dogs, cats, ferrets 53 3.8 Large mammals - pigs, sheep, goats, cattle, horses 57 3.9 Non-human primates 61 3.10 Other animals not commonly used for experiments 62 4. -
Pyridoxine in Clinical Toxicology: a Review Philippe Lheureux, Andrea Penaloza and Mireille Gris
78 Review Pyridoxine in clinical toxicology: a review Philippe Lheureux, Andrea Penaloza and Mireille Gris Pyridoxine (vitamin B6) is a co-factor in many enzymatic controversial. This paper reviews the various indications pathways involved in amino acid metabolism: the main of pyridoxine in clinical toxicology and the supporting biologically active form is pyridoxal 5-phosphate. literature. The potential adverse effects of excessive Pyridoxine has been used as an antidote in acute pyridoxine dosage will also be summarized. intoxications, including isoniazid overdose, Gyromitra European Journal of Emergency Medicine 12:78–85 mushroom or false morrel (monomethylhydrazine) c 2005 Lippincott Williams & Wilkins. poisoning and hydrazine exposure. It is also recommended as a co-factor to improve the conversion of glyoxylic acid European Journal of Emergency Medicine 2005, 12:78–85 into glycine in ethylene glycol poisoning. Other indications Keywords: Antidotes, crimidin, drug-induced neuropathy, ethylene glycol, are recommended by some sources (for example crimidine hydrazine, isoniazid, metadoxine, pyridoxine poisoning, zipeprol and theophylline-induced seizures, adjunct to d-penicillamine chelation), without significant Department of Emergency Medicine, Erasme University Hospital, Brussels, Belgium. supporting data. The value of pyridoxine or its congener Correspondence to Philippe Lheureux, Department of Emergency Medicine, metadoxine as an agent for hastening ethanol metabolism Erasme University Hospital, 808 route de Lennik, 1070 Brussels, Belgium. or improving vigilance in acute alcohol intoxication is E-mail: [email protected] Introduction ing. More controversial issues include alcohol intoxication Pyridoxine or vitamin B6 is a highly water-soluble and zipeprol or theophylline-induced seizures. vitamin. Its main biologically active form is a phosphate ester of its aldehyde form, pyridoxal 5-phosphate (P5P). -
Gyromitrin Poisoning: More Questions Than Answers
Gyromitrin poisoning: more questions than answers Denis R. Benjamin, MD some dedicated mycophagist, who had Many of these clues to the toxin never eaten the mushroom for many years made any coherent sense, even though it “It is perhaps ironic for a mushroom, without any ill effects, would suddenly was known for some years that the toxins Gyromitra esculenta, whose very name and unaccountably take ill. This too could be destroyed by cooking.” (From means edible, to be so poisonous under was passed off as the development of an Benjamin, 1995.) certain circumstances. Surprisingly, allergy in the unfortunate individual, the toxins were only characterized as that the mushrooms had been mistaken ll the enigmas related to this recently as 1968. A number of factors for a poisonous variety, or a rotten toxin remain unresolved. The conspired against the investigators of this batch had been eaten. To compound the current literature merely repeats mushroom poison (Lincoff and Mitchel, difficulties, Gyromitra esculenta caused Awhat was published before 1990. A 1977). The first was the observation that many poisonings in Europe, while in the deluge of “cut and paste.” No meaningful only a few of the participants eating the western USA, the seemingly identical research has been done in the past same quantity of the same mushroom species appeared largely harmless. All three decades. This is due to a number would become ill. Because of this, the sorts of explanations were proposed of factors. The first was the demise of poisoning was immediately ascribed to to explain this discrepancy, including academic pharmacognosy departments, ‘allergy’ or ‘individual idiosyncrasy.’ The such fanciful ones as suggesting that responsible for investigating the biology next problematic observation was that Americans cook their vegetables better. -
Toxicological Profile for Hydrazines. US Department Of
TOXICOLOGICAL PROFILE FOR HYDRAZINES U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 1997 HYDRAZINES ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. HYDRAZINES iii UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 HYDRAZINES vii CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): Gangadhar Choudhary, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Hugh IIansen, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Steve Donkin, Ph.D. Sciences International, Inc., Alexandria, VA Mr. Christopher Kirman Life Systems, Inc., Cleveland, OH THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1 . Green Border Review. Green Border review assures the consistency with ATSDR policy. 2 . Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. HYDRAZINES ix PEER REVIEW A peer review panel was assembled for hydrazines. The panel consisted of the following members: 1. Dr. -
Chemical Compatibility Chart X
Chemical Compatibility Chart Below is a chart adapted from the CRC Laboratory Handbook, which groups various chemicals in to 23 groups with examples and incompatible chemical groups. This chart is by no means complete but it will aid in making decisions about storage. For more complete information please refer to the MSDS for the specific chemical. Examples of each group can be found on the next pages. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Monomers Polymerizable Esters Alcohols, Glycols, Glycol Ether Amines and Alkanolamines Halogenated Compounds Aldehydes Acetaldehyde Saturated Hydrocar Aromatic Hydrocarbons Acid Anhydrides Alkylene Oxides Inorganic Acids Petrolium Oils Organic Acids Cyanohydrins Phosphorus Ammonia Group Halogens Ketones Caustics Phenols Nitriles Olefins Ethers Number/Chemical Esters Type bons Inorganic 1 x x x x x x x x x x x x x x x x x Acids 2 Organic Acids x x x x x x x x x x 3 Caustics x x x x x x x x x x x x x Amines and 4 x x x x x x x x x x x x Alkanolamines Halogenated 5 x x x x x x Compounds Alcohols, 6 Glycols, Glycol x x x x x x Ether Aldehydes 7 x x x x x x x x x x x x Acetaldehyde 8 Ketones x x x x x x Saturated 9 x Hydrocarbons Aromatic 10 x x Hydrocarbons 11 Olefins x x x 12 Petrolium Oils x 13 Esters x x x x x Monomers 14 Polymerizable x x x x x x x x x x x x Esters 15 Phenols x x x x x x x Alkylene 16 x x x x x x x x x x x x Oxides 17 Cyanohydrins x x x x x x x x x 18 Nitriles x x x x x x 19 Ammonia x x x x x x x x x x x 20 Halogens x x x x x x x x x x x x x x 21 Ethers x x x 22 Phosphorus x x x x Acid 23 x x x x x x x x x x Anhydrides X - Indicates chemicals that are incompatible and should not be stored together. -
Section 2 - Hazardous Ingredients
rev- OUR PRODUCTS HAVE NO OZONE DEPLETING SUBSTANCES. (ODS) SAFETY DATA SHEET - STAY-CLEAN* SOLDERING FLUXES SECTION 1 Address Manufacturer's Name Cincinnati, OH 45242 j. w. Harris Co., Inc. 10930 Deerfield Rd. 1-800-424-9300 ES 8/92 Emergency Telephone No. Date Prepared 6/93 SUP 1-513-891-2000 Telephone Mo. for Information Signature of Preparer: Section 2 - hazardous ingredients STAY-CLEAN LIQUID FLUX PEL MG/M3 TLV MG/M3 STEL MG/M3 INGREDIENT CAS NUMBER 1.0 Zinc Chloride* 7646-85-7 <40% 1.0 7.5 Not listed Hydrogen chloride* 7647-01-0 <15% 7.0 12125-02-9<25% 10.0 10.0 20 Ammonium chloride Not listed 7732-18-5 <70% Not listed Not listed Water 260.0 262.0 325 Methanol* 67-56-1 <5% STAY-CLEAN PASTE FLUX PEL MG/M3 TLV MG/M3 STEL MG/M3 INGREDIENT CAS NUMBER 1.0 Zinc Chloride* 7646-85-7 <40% 1.0 Not listed Not listed Not listed Petrolatum Not listed <80% 127 ceiling Not listed Ethylene Glycol 107-21-1 <15% 125 ceiling 10.0 20 Ammonium Chloride 12125-02-9 <10% 10.0 Not listed Not listed Not listed Water 7732-18-5 <10% STAY-CLEAN ALUMINUM FLUX PEL MG/M3 TLV MG/M3 STEL MG/M3 INGREDIENT CAS NUMBER 2.5 Not listed Ammonium Fluoborate 13826-83-0 2.5 Not listed Not listed Aminoethylethanolamine 111-41-1 Not listed Not listed 60 Triethanolamine 102-71-6 Not listed 2.0 Not listed Tin as Sn* 7440-31-5 <10% 2.0. -
Förordning Om Ändring I Förordningen (1992:1554) Om Kontroll Av Narkotika;
Príloha 11 k rozhodnutiu švédskych úradov vlády 22. februára 2018 § 79 1. ------IND- 2018 0079 S-- SK- ------ 20180302 --- --- PROJET Zbierka zákonov Švédska SFS Published on issued on 1 March 2018. The government hereby lays down1 that Annex 1 to the Ordinance (1992:1554) on the control of narcotic drugs2 shall read as set out below. This ordinance shall enter into force on 10 April 2018. On behalf of the Government ANNIKA STRANDHÄLL Lars Hedengran (Ministry of Health and Social Affairs) 1 See Directive (EU) 2015/1535 of the European Parliament and of the Council of 9 September 2015 laying down a procedure for the provision of information in the field of technical regulations and of rules on Information Society services. 2 Ordinance reprinted as 1993:784. 1 SFS Annex 13 List of substances to be considered narcotic drugs according to the Narcotic Drugs Punishments Act Stimulants of the central nervous system ethylamphetamine (2-ethylamino-1-phenylpropane) fenethylline [1-phenyl-1-piperidyl-(2)-methyl]acetate 1-phenyl-2-butylamine N-hydroxyamphetamine propylhexedrine 4-methylthioamphetamine (4-MTA) modafinil 4-methoxy-N-methylamphetamine (PMMA, 4-MMA) 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2) 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) 4-iodo-2,5-dimethoxyphenethylamine (2C-I) 2,4,5-trimethoxyamphetamine (TMA-2) 4-methylmethcathinone (mephedrone) 4-fluoramphetamine 1-(4-methoxyphenyl)-2-(methylamino)propan-1-one (methedrone) 1-(1,3-benzodioxol-5-yl)-2-pyrrolidin-1-yl-pentan-1-one (MDPV) 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one -
TERTIARY ACETYLENIC ALCOHOLS Compound, Ethchlorvynol (S 94) Is
36 H. ISBELL & T. L. CHRUSCIEL TERTIARY ACETYLENIC ALCOHOLS Only two compounds are listed (Table IV). Of 152. Csarza-Perez, J., Lal, S. & Lopez, E. (1967) Med. these, methylpentynol (S 95) is a weak, short-acting Serv. J. Can., 23, No. 5, 775-778 (Addiction to hypnotic. Sales have been low and few instances chlorvynol) of abuse have been reported.155' 157 The other 153. Essig, C. F. (1964) Clin. Pharmacol., 5, 334 (Addic- compound, ethchlorvynol (S 94) is more potent and tion to sedatives and tranquilizers) instances of abuse are more frequent. There is 154. Government of the United States of America, stiong clinical documentation for abrupt withdrawal US Food and Drug Administration (1965) Back- of ethchlorvynol being followed by convulsions and ground material supplied to Advisory Committee delirium.151-154, 156 Accordingly, ethchlorvynol must on Abuse of Stimulant and Depressant Drugs, be judged to have moderate abuse potential and 27 December 1965, Washington, D.C. 155. Hitsche, B. & Herbst, A. (1967) Psychiat. et methylpentynol must, by analogy, be regarded as Neurol. (Basel), 153, 308-318 (Beobachtungen having dependence potential equivalent to that of bei Missbrauch von Methylpentinol) ethchlorvynol. 156. Hudson, H. S. & Walker, H. I. (1961) Amer. J. Psychiat., 118, 361 (Withdrawal symptoms REFERENCES following ethchlorvynol (Placidyl) dependence) 157. Marley, E. & Bartholomew, A. A. (1958) J. Neurol. 151. Cohn, C. H. (1959) Canad. med. Ass. J., 81, 733 Neurosurg. Psychiat., 21, 129-140 (Clinical (Intoxication by ethchlorvynol-Placidyl) aspects of susceptibility of methylpentol) CYCLIC ETHERS The only compound in this group is paraldehyde dogs physically dependent on barbital.