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(12) United States Patent (10) Patent No.: US 8,846,029 B2 Israelsen (45) Date of Patent: Sep

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(12) United States Patent (10) Patent No.: US 8,846,029 B2 Israelsen (45) Date of Patent: Sep USOO8846O29B2 (12) United States Patent (10) Patent No.: US 8,846,029 B2 Israelsen (45) Date of Patent: Sep. 30, 2014 (54) TREATMENT OF IBD AND IBS USING BOTH 5,591,428 A 1/1997 Bengmarket al. PROBOTC BACTERIA AND FERMENTED &SR 1339. th st al CEREAL ASTREATMENT EFFECTORS 7,220,409- - B2 5/2007 NormanOSSO et ca.al. 7,311.932 B1 12/2007 Berggren et al. (75) Inventor: Hans Israelsen, Allerod (DK) 2004/0028667 A1 2/2004 Norman et al. 2004/0048356 A1 3/2004 Johansson et al. ......... 435/252.3 (73) Assignee: Nordisk Rebalance A/S, Allerod (DK) FOREIGN PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 RE 8:15 A. ck 58: U.S.C. 154(b) by 0 days. DE 10258129 A1 6, 2004 EP O 1995.35 A2 10, 1986 (21) Appl. No.: 13/540,827 EP O 1995.35 A3 10, 1986 EP O271364 A2 6, 1988 (22) Filed: Jul. 3, 2012 EP O271364 A3 6, 1988 EP 415941 A1 3, 1991 O O EP O 1995.35 B1 1, 1992 (65) Prior Publication Data EP O271364 B1 9, 1992 US 2012/O269791 A1 Oct. 25, 2012 EP 554418 A1 8/1993 EP O 1995.35 B2 11/1995 WO WO89,05849 A1 6, 1989 Related U.S. Application Data WO WO89,08405 A1 9, 1989 WO WO91/O585.0 A1 5, 1991 (62) Division of application No. 12/066,246, filed as W W. E. A. E. pation No. PCT/DK2006/000526 on Sep. 27, WO WO930.1823 A1 2/1993 WO WO9629O83 A1 9, 1996 WO WO991.8188 A1 4f1999 (60) s sal prov1s1onalapplits applicationCE. No. s 4Y. V: WO WOOWOOO70972 1/70246 A1 11/20009, 2001 filed on Sep. 28, 2005. WO WOO218442 A1 3f2002 WO WOO2,39834 A1 5/2002 (30) Foreign Application Priority Data WO WOO2/O86136 A1 10, 2002 WO WO2004O67731 A1 8, 2004 Sep. 28, 2005 (EP) ..................................... 0.5388070 WO WO2004087893 Al 10/2004 Apr. 12, 2006 (DK) ................................. 2006 OO529 OTHER PUBLICATIONS (51) Int. Cl. AOIN 63/00 (2006.01) Jonkers, D and Stockbrugger, R“Probiotics and Inflammatory Bowel CI2N L/20 (2006.01) Disease” J R Soc Med. Apr. 2003: 96(4): 167-171.* A6 IK35/74 (2006.01) DSMZ “Lactobacillus plantarum” DSMZ catalogue, accessed A 6LX36/899 (2006.01) online (URL:http://www.dsmz.de/catalogues/catalogue-microor A2.3L I/30 (2006.01) ganisms.html#searchResult, retrieved Aug. 27, 2012, 2 pages. A6 IK 45/06 (2006.01) (Continued) A6 IK3I/685 (2006.01) A6 IK35/66 (2006.01) A2.3L. I./72 (2006.01) Primary Examiner—Jon PWeber (52) U.S.AV e. Clwe AssistantSSiStant ExamiExaminer — Aaron JKOSa CPC ......... A61K 35/66 (2013.01); A23 V 2200/3204 (74) Attorney, Agent, or Firm — McLane, Graf, Raulerson & (2013.01); A61 K35/744 (2013.01); A61 K Middleton, PA 36/899 (2013.01); A61 K35/745 (2013.01); s A61K 35/74 (2013.01); A23L I/3014 (2013.01); A23 V 2002/00 (2013.01); A61K 45/06 (57) ABSTRACT (2013.01); A61 K3I/685 (2013.01); A61 K 35/742 (2013.01); A61 K35/747 (2013.01); The invention covers a novel treatment strategy that consid A2.3L I/I 72 (2013.01) erably improves conventional probiotic treatments of inflam USPC ..................................... 424/93.45; 435/252.9 matory bowel diseases, irritable bowel syndrome and other (58) Field of Classification Search gastrointestinal disorders. Both probiotic microorganisms None and the carrier of the probiotic microorganisms in form of a See application file for complete search history. fermented cereal gruel are used as treatment effectors. Phos pholipids may also be an effector. The novel treatment strat (56) References Cited egy is capable of removing the symptoms of inflammatory U.S. PATENT DOCUMENTS bowel diseases regardless of a mild, moderate or severe stage of the disease. 5, 190,755 A 3, 1993 Molin et al. 5,474,932 A 12/1995 Bengmarket al. 5,587,314 A 12/1996 Bengmarket al. 28 Claims, No Drawings US 8,846,029 B2 Page 2 (56) References Cited Stremmel, W. et al., “Delayed Release Phosphatidylcholine as New Therapeutic Drug for Ulcerative Colitis—a Review of Three Clinical OTHER PUBLICATIONS Trials”. Expert Opin. Investig. Drugs, 19(12), pp. 1623-1630, 2010. Stremmel, W. et al., “Retarded Release Phosphatidylcholine Benefits Blandino, A.; Al-Aseeri, M. E.; Pandiella, SS; Cantero, D.; Webb, C Patients with Chronic Active Ulcerative Colitis'. Gut Online, 54:966 "Cereal-based Fermented Foods and Beverages' Food Research 971, 2005. 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