DOCSLIB.ORG

Annual Meeting Program and Abstracts Boca Raton, Florida, USA June 27-July 2, 2018

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Annual Meeting Program and Abstracts Boca Raton, Florida, USA June 27-July 2, 2018 Annual Meeting Program and Abstracts Boca Raton, Florida, USA June 27-July 2, 2018 Abstracts of the 27th Annual Meeting of the International Behavioral Neuroscience Society Volume 27, June 2018 Contents PRESIDENTIAL WELCOME ................................................................................................ 3 OFFICERS.......................................................................................................................... 4 COUNCIL MEMBERS ......................................................................................................... 4 AWARDS .......................................................................................................................... 5 TRAVEL AWARDS ............................................................................................................. 6 SPONSORS/EXHIBITORS ................................................................................................... 7 PROGRAM ........................................................................................................................ 9 Wednesday, June 27 ............................................................................................................................................ 9 Thursday, June 28 ................................................................................................................................................. 9 Friday, June 29 ................................................................................................................................................... 15 Saturday, June 30 ............................................................................................................................................... 23 Sunday, July 1 ..................................................................................................................................................... 31 ABSTRACTS .................................................................................................................... 36 Thursday, June 28 ............................................................................................................................................... 36 Friday, June 29 ................................................................................................................................................... 62 Saturday, June 30 ............................................................................................................................................. 106 Sunday, July 1 ................................................................................................................................................... 152 IBNS CENTRAL OFFICE Marianne Van Wagner, Executive Director (830) 796-9393 tel. Eve Van Wagner, Business and Events Coordinator (830) 796-9394 fax International Behavioral Neuroscience Society (866) 377-4416 (toll-free from within the US) 1123 Comanche Path [email protected] Bandera, Texas 78003-4212 USA http://www.ibnsconnect.org Connect with IBNS! 2 PRESIDENTIAL WELCOME F. Scott Hall, PhD IBNS President Department of Pharmacology and Experimental Therapeutics University of Toledo College of Pharmacy and Pharmaceutical Sciences Toledo, Ohio, USA Dear Friends and Colleagues, I am delighted to welcome you to the 27th Annual Meeting of the International Behavioral Neuroscience Society (IBNS). As you are no doubt aware, the meeting had been originally planned for Puerto Rico, which continues to recover from the devastating consequences of Hurricane Maria. Even now, so long after the event, the Island is struggling to recover, and estimates of the full toll of the disaster continue to climb. We continue to ask all our members to reach out to colleagues in Puerto Rico, and to the community at large, and to help where you can. We were very fortunate to have support from Plexon and Thorlabs, who made contributions allowing 5 deserving students from Puerto Rico to attend the IBNS meeting this year. We thank them very much for their generosity that has benefited these deserving students. After it became clear that we would have to move the location of the meeting, we were quite lucky to be able to hold the meeting in beautiful Boca Raton, Florida, but not without herculean efforts on the part of the IBNS staff, the IBNS Executive Director Marianne Van Wagner and our Business and Event Manager, Eve Van Wagner. This meeting could not have happened, and indeed our Society would not have continued to exist, without their steadfast loyalty and long- standing contributions to the Society. I extend to them our deepest thanks. I would also like to thank our plenary speakers for being so helpful and accommodating with the change in venue. Much effort had originally gone into plans for Puerto Rico, so I would like to thank the original local organizing committee (LOC) from Puerto Rico (Carmen Maldonado-Vlaar, Arlene Martinez, Yancy Ferrer-Acosta, Carlos, Bolanos and Dinah Ramos- Ortolaza) for their hard work. I would especially like to thank a late addition to the LOC from Florida, Marcelo Febo, for his help and advice after the meeting had been moved to Florida. Putting on a meeting like this requires a great deal of work from many people. The program this year has been enlarged and enriched, with 3 simultaneous symposia, and more presentations than at any previous IBNS meeting. This could not have happened without tremendous (and time-consuming) efforts from the Program Committee and its Chair, Elena Choleris, and Co-Chair, Farida Sohrabji. This year IBNS also gave away more student and post-doctoral travel awards than ever before, to a very impressive group of young scientists. We are appreciative of their work and efforts and will show- case their work, as always, in the Travel Award Blitz. Choosing the award winners from among the accomplished applicants was the very difficult work of the Education and Training Committee, and its Chair, Stacey Sukoff Rizzo, and Co-Chair, Corina Bondi. We thank them all for their diligence, time and hard work. Lastly, I wish to acknowledge our student representative, Cindy Barha, for her numerous contributions to the meeting. IBNS is also exceedingly thankful for the support of its sponsors. First and foremost among this group is the long-standing and continuing support of Elsevier Science, the publisher of our official journals, Neuroscience & Biobehavioral Reviews and Pharmacology, Biochemistry and Behavior, who will once again hold a lunchtime seminar on scientific publishing. We would also like to recognize our major sponsors Plexon, Thorlabs, Stoelting, Harvard Bioscience, and Noldus for their support of the meeting. Noldus has also helped to organize and sponsor, with Past-President Robert Gerlai, a lunchtime workshop on Zebrafish methods, and we are very appreciative of their efforts. We are thankful to all our sponsors and exhibitors and encourage you to visit their booths during the breaks at the conference to discuss your research needs. I am looking forward to another outstanding meeting in Boca Raton, Florida. Best wishes, F. Scott Hall President, IBNS 3 OFFICERS President ............................................................................................................................ F. Scott Hall Past-President ............................................................................................................ Mikhail Pletnikov Secretary .......................................................................................................................... Corina Bondi Treasurer .................................................................................................................... Mikhail Pletnikov Past Presidents Stephen Kent ....................................................................................................................... 2013-2014 D. Caroline Blanchard ........................................................................................................... 2011-2012 Kelly Lambert ...................................................................................................................... 2009-2010 Robert Gerlai ...................................................................................................................... 2007-2008 Joseph Huston .............................................................................................................................. 2006 Robert Adamec ............................................................................................................................. 2005 C. Sue Carter................................................................................................................................. 2004 Robert J. Blanchard ....................................................................................................................... 2003 Mark A. Geyer ............................................................................................................................... 2002 John P. Bruno ............................................................................................................................... 2001 Jacqueline N. Crawley .................................................................................................................. 2000 László Lénárd ............................................................................................................................... 1999 Robert L. Isaacson .......................................................................................................................
Load more

Recommended publications
  • Pharmacogenetics of Ketamine Metabolism And
    Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine Yibai Li B.HSc. (Hons) Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide September 2014 A thesis submitted for the Degree of PhD (Medicine) Table of contents TABLE OF CONTENTS .............................................................................................. I LIST OF FIGURES ....................................................................................................IV LIST OF TABLES ......................................................................................................IV ABSTRACT ............................................................................................................... V DECLARATION .......................................................................................................VIII ACKNOWLEDGEMENTS ..........................................................................................IX ABBREVIATIONS .....................................................................................................XI CHAPTER 1. INTRODUCTION .................................................................................. 1 1.1 A historical overview of ketamine ........................................................................................ 1 1.2 Structure and Chemistry ....................................................................................................... 3 1.3 Classical analgesic mechanisms of ketamine ...................................................................
    [Show full text]
  • Opioid Withdrawal ��������������������������������������������������������������������������������������������������� 15 Mark S
    Magdalena Anitescu Honorio T. Benzon Mark S. Wallace Editors Challenging Cases and Complication Management in Pain Medicine 123 Challenging Cases and Complication Management in Pain Medicine Magdalena Anitescu Honorio T. Benzon • Mark S. Wallace Editors Challenging Cases and Complication Management in Pain Medicine Editors Magdalena Anitescu Honorio T. Benzon Department of Anesthesia and Critical Care Department of Anesthesiology University of Chicago Medicine Northwestern University Chicago, IL Feinberg School of Medicine USA Chicago, IL USA Mark S. Wallace Division of Pain Medicine Department of Anesthesiology University of California San Diego School of Medicine La Jolla, CL USA ISBN 978-3-319-60070-3 ISBN 978-3-319-60072-7 (eBook) https://doi.org/10.1007/978-3-319-60072-7 Library of Congress Control Number: 2017960332 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication.
    [Show full text]
  • Question of the Day Archives: Monday, December 5, 2016 Question: Calcium Oxalate Is a Widespread Toxin Found in Many Species of Plants
    Question Of the Day Archives: Monday, December 5, 2016 Question: Calcium oxalate is a widespread toxin found in many species of plants. What is the needle shaped crystal containing calcium oxalate called and what is the compilation of these structures known as? Answer: The needle shaped plant-based crystals containing calcium oxalate are known as raphides. A compilation of raphides forms the structure known as an idioblast. (Lim CS et al. Atlas of select poisonous plants and mushrooms. 2016 Disease-a-Month 62(3):37-66) Friday, December 2, 2016 Question: Which oral chelating agent has been reported to cause transient increases in plasma ALT activity in some patients as well as rare instances of mucocutaneous skin reactions? Answer: Orally administered dimercaptosuccinic acid (DMSA) has been reported to cause transient increases in ALT activity as well as rare instances of mucocutaneous skin reactions. (Bradberry S et al. Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. 2009 Q J Med 102:721-732) Thursday, December 1, 2016 Question: What is Clioquinol and why was it withdrawn from the market during the 1970s? Answer: According to the cited reference, “Between the 1950s and 1970s Clioquinol was used to treat and prevent intestinal parasitic disease [intestinal amebiasis].” “In the early 1970s Clioquinol was withdrawn from the market as an oral agent due to an association with sub-acute myelo-optic neuropathy (SMON) in Japanese patients. SMON is a syndrome that involves sensory and motor disturbances in the lower limbs as well as visual changes that are due to symmetrical demyelination of the lateral and posterior funiculi of the spinal cord, optic nerve, and peripheral nerves.
    [Show full text]
  • Fundamentals of C.R.P.S
    FUNDAMENTALS OF C.R.P.S. PHILIP GETSON, D.O. SEPTEMBER 11, 2015 R.S.D. Association National Conference I DON’T KNOW ! Philip Getson, D.O. October 22, 1999 Third National RSD Association Conference Atlantic City N.J. HISTORY The first mention of CRPS dates back to the 17th Century when surgeon Ambrose Pare reported that King Charles IX suffered from persistent pain and contracture of his arm following a bloodletting procedure During the Civil War Mitchell described soldiers suffering from burning pain due to gunshot wounds. He termed this Causalgia In 1900 Sudek described complications of trauma to the limbs with swelling, limitation of motor function and resistance to treatment The term Reflex Sympathetic Dystrophy was first used by Evans in 1946 NOMENCLATURE Causalgia Sudek’s Atrophy Post traumatic Pain Syndrome Post traumatic Painful Arthrosis Sudek’s Dystrophy Post Traumatic Edema Reflex Dystrophy Shoulder Hand Syndrome Chronic Traumatic Edema Algodystrophy Peripheral Trophoneurosis Sympathalgia Reflex Sympathetic Dystrophy Reflex Neurovascular dystrophy DEFINITION Complex Regional Pain is a neuropathic/inflammatory pain disorder characterized by: 1. Severe pain that extends beyond the injured area and is disproportionate to the inciting event. 2. Autonomic dysregulation 3. Edema – usually neuropathic in nature 4. Movement disorders 5. Atrophy and/or dystrophy CAUSE There is no single cause of CRPS Some more common are: sprain, contusion, surgery, fracture, infections, myocardial infarctions, carpel tunnel syndrome,
    [Show full text]
  • Modulation of NMDA Receptor Activity During Physiological and Pathophysiological Events Christine Marie Emnett Washington University in St
    Washington University in St. Louis Washington University Open Scholarship Arts & Sciences Electronic Theses and Dissertations Arts & Sciences Winter 12-15-2014 Modulation of NMDA Receptor Activity During Physiological and Pathophysiological Events Christine Marie Emnett Washington University in St. Louis Follow this and additional works at: https://openscholarship.wustl.edu/art_sci_etds Part of the Biology Commons Recommended Citation Emnett, Christine Marie, "Modulation of NMDA Receptor Activity During Physiological and Pathophysiological Events" (2014). Arts & Sciences Electronic Theses and Dissertations. 347. https://openscholarship.wustl.edu/art_sci_etds/347 This Dissertation is brought to you for free and open access by the Arts & Sciences at Washington University Open Scholarship. It has been accepted for inclusion in Arts & Sciences Electronic Theses and Dissertations by an authorized administrator of Washington University Open Scholarship. For more information, please contact [email protected]. WASHINGTON UNIVERSITY IN ST. LOUIS Division of Biology and Biomedical Sciences Neurosciences Dissertation Examination Committee: Steven Mennerick, Chair James Huettner Daniel Kerschensteiner Peter D. Lukasiewicz Joseph Henry Steinbach Modulation of NMDA Receptor Activity During Physiological and Pathophysiological Events by Christine Marie Emnett A dissertation presented to the Graduate School of Arts and Sciences of Washington University in partial fulfillment of the requirements for the degree of Doctor of Philosophy December 2014
    [Show full text]
  • Neurotransmission Product Guide | Edition 1
    Neurotransmission Product Guide | Edition 1 Delphinium Delphinium A source of Methyllycaconitine Contents by Research Area: • Dopaminergic Transmission • Glutamatergic Transmission • Opioid Peptide Transmission • Serotonergic Transmission • Chemogenetics Tocris Product Guide Series Neurotransmission Research Contents Page Principles of Neurotransmission 3 Dopaminergic Transmission 5 Glutamatergic Transmission 6 Opioid Peptide Transmission 8 Serotonergic Transmission 10 Chemogenetics in Neurotransmission Research 12 Depression 14 Addiction 18 Epilepsy 20 List of Acronyms 22 Neurotransmission Research Products 23 Featured Publications and Further Reading 34 Introduction Neurotransmission, or synaptic transmission, refers to the passage of signals from one neuron to another, allowing the spread of information via the propagation of action potentials. This process is the basis of communication between neurons within, and between, the peripheral and central nervous systems, and is vital for memory and cognition, muscle contraction and co-ordination of organ function. The following guide outlines the principles of dopaminergic, opioid, glutamatergic and serotonergic transmission, as well as providing a brief outline of how neurotransmission can be investigated in a range of neurological disorders. Included in this guide are key products for the study of neurotransmission, targeting different neurotransmitter systems. The use of small molecules to interrogate neuronal circuits has led to a better understanding of the under- lying mechanisms of disease states associated with neurotransmission, and has highlighted new avenues for treat- ment. Tocris provides an innovative range of high performance life science reagents for use in neurotransmission research, equipping researchers with the latest tools to investigate neuronal network signaling in health and disease. A selection of relevant products can be found on pages 23-33.
    [Show full text]
  • FSU ETD Template
    Florida State University Libraries Electronic Theses, Treatises and Dissertations The Graduate School 2018 Sex Differences in the Effects of Low- Dose Ketamine in Rats: A Behavioral, Pharmacokinetic and Pharmacodynamic Analysis Samantha K. Saland Follow this and additional works at the DigiNole: FSU's Digital Repository. For more information, please contact [email protected] FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE SEX DIFFERENCES IN THE EFFECTS OF LOW-DOSE KETAMINE IN RATS: A BEHAVIORAL, PHARMACOKINETIC AND PHARMACODYNAMIC ANALYSIS By SAMANTHA K. SALAND A Dissertation submitted to the Department of Biomedical Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy 2018 Samantha Saland defended this dissertation on April 18, 2018. The members of the supervisory committee were: Mohamed Kabbaj Professor Directing Dissertation Thomas Keller University Representative James Olcese Committee Member Branko Stefanovic Committee Member Zuoxin Wang Committee Member The Graduate School has verified and approved the above-named committee members, and certifies that the dissertation has been approved in accordance with university requirements. ii I dedicate this work to my loving husband and to my parents—without their endless encouragement and unconditional support throughout the years, this would not have been possible. iii ACKNOWLEDGEMENTS I would like to acknowledge all those in the Department of Biomedical Sciences here at Florida State University who have made it possible for me to succeed, not only through financial and research support, but by providing an environment of opportunity, understanding and encouragement time and again during my time in the graduate program. I would also like to express my gratitude to my committee members for their continued guidance and support throughout all these years—thank you for challenging me and expanding my continuous search for knowledge.
    [Show full text]
  • WO 2013/056229 Al 18 April 2013 (18.04.2013) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2013/056229 Al 18 April 2013 (18.04.2013) P O P C T (51) International Patent Classification: Marc C. [US/US]; 1120 Deer Run Court, Southampton, C07C 225/20 (2006.01) A61P 25/28 (2006.01) Pennsylvania 18966 (US). GOLDBERG, Michael E. C07C 237/02 (2006.01) A61P 25/00 (2006.01) [US/US]; 113 North Bread Street, Unit 9E, Philadelphia, C07D 295/155 (2006.01) A61K 31/133 (2006.01) Pennsylvania 19106 (US). C07D 295/145 (2006.01) A61K 31/122 (2006.01) (74) Agent: MAXWELL, Leslie-Anne; Cantor Colburn LLP, A61P 25/04 (2006.01) 20 Church Street, 22nd Floor, Hartford, Connecticut 06103 (21) International Application Number: (US). PCT/US2012/060256 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 15 October 2012 (15.10.2012) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, English (25) Filing Language: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (30) Priority Data: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 61/547,336 14 October 201 1 (14. 10.201 1) US NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (71) Applicants: THE UNITED STATES OF AMERICA, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, AS REPRESENTED BY THE SECRETARY, DE¬ TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, PARTMENT OF HEALTH AND HUMAN SERVICES ZM, ZW.
    [Show full text]
  • (R,S)-Ketamine, (2R,6R)-Hydroxynorketamine, and (2S,6S)-Hydroxynorketamine
    www.nature.com/npp ARTICLE Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine Briana K. Chen 1, Victor M. Luna2,3, Christina T. LaGamma2,9, Xiaoming Xu4,5, Shi-Xian Deng4,5, Raymond F. Suckow3,6, Thomas B. Cooper3,6, Abhishek Shah 7, Rebecca A. Brachman3, Indira Mendez-David8, Denis J. David8, Alain M. Gardier8, Donald W. Landry4,5 and Christine A. Denny 2,3 Enhancing stress resilience in at-risk populations could significantly reduce the incidence of stress-related psychiatric disorders. We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavior in male mice, perhaps by altering α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated transmission in hippocampal CA3. However, it is still unknown whether metabolites of (R,S)-ketamine can be prophylactic in both sexes. We administered (R,S)-ketamine or its metabolites (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) and (2S,6S)-hydroxynorketamine ((2S,6S)- HNK) at various doses 1 week before one of a number of stressors in male and female 129S6/SvEv mice. Patch clamp electrophysiology was used to determine the effect of prophylactic drug administration on glutamatergic activity in CA3. To examine the interaction between ovarian hormones and stress resilience, female mice also underwent ovariectomy (OVX) surgery and a hormone replacement protocol prior to drug administration. (2S,6S)-HNK and (2R,6R)-HNK protected against distinct stress- 1234567890();,: induced behaviors in both sexes, with (2S,6S)-HNK attenuating learned fear in male mice, and (2R,6R)-HNK preventing stress- induced depressive-like behavior in both sexes.
    [Show full text]
  • Efficacy and Safety of Intranasal Esketamine When Tapered from Twice-Weekly Dosing to Once Per Week Dosing and Then Dosing Once Every Other Week
    Janssen Research & Development * Clinical Protocol A Double-Blind, Doubly-Randomized, Placebo-Controlled Study of Intranasal Esketamine in an Adaptive Treatment Protocol to Assess Safety and Efficacy in Treatment-Resistant Depression (SYNAPSE) Protocol ESKETINTRD2003; Phase 2a AMENDMENT INT-3 JNJ-54135419 (esketamine) *Janssen Research & Development is a global organization that operates through different legal entities in various countries. Therefore, the legal entity acting as the sponsor for Janssen Research & Development studies may vary, such as, but not limited to Janssen Biotech, Inc.; Janssen Products, LP; Janssen Biologics, BV; Janssen-Cilag International NV; Janssen, Inc; Janssen Infectious Diseases BVBA; Janssen R&D Ireland; or Janssen Research & Development, LLC. The term “sponsor” is used throughout the protocol to represent these various legal entities; the sponsor is identified on the Contact Information page that accompanies the protocol. This study will be conducted under US Food & Drug Administration IND regulations (21 CFR Part 312). EudraCT NUMBER: 2013-004005-11 Status: Approved Date: 28 April 2014 Prepared by: Janssen Research & Development, LLC EDMS No & Version: EDMS-ERI-71950055:5.0 GCP Compliance: This study will be conducted in compliance with Good Clinical Practice, and applicable regulatory requirements. Confidentiality Statement The information in this document contains trade secrets and commercial information that are privileged or confidential and may not be disclosed unless such disclosure is required by applicable law or regulations. In any event, persons to whom the information is disclosed must be informed that the information is privileged or confidential and may not be further disclosed by them. These restrictions on disclosure will apply equally to all future information supplied to you that is indicated as privileged or confidential.
    [Show full text]
  • (2R,6R)-Hydroxynorketamine (HNK) Targets Glucocorticoid
    bioRxiv preprint doi: https://doi.org/10.1101/2020.09.03.280834; this version posted March 19, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Title Rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) targets glucocorticoid receptor signaling: a longitudinal cerebrospinal fluid proteome study Authors David P. Herzog1,* MD; Natarajan Perumal2,* PhD; Caroline Manicam2 PhD; Giulia Treccani1,3,4 PhD; Jens Nadig1; Milena Rossmanith2; Jan Engelmann1 MD; Tanja Jene1 MS; Annika Hasch1 MS; Michael A. van der Kooij1,5 PhD; Klaus Lieb1,5 MD; Nils C. Gassen6 PhD; Franz H. Grus2 MD PhD; Marianne B. Müller1,5 MD Affiliations 1Department of Psychiatry and Psychotherapy and Focus Program Translational Neurosciences, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany. 2Experimental and Translational Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University Medical Center, Mainz, Germany. 3Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University Medical Center, Mainz, Germany. 4Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark. 5Leibniz Institute for Resilience Research, Mainz, Germany. 6Neurohomeostasis Research Group, Department of Psychiatry and Psychotherapy, University Medical Center Bonn, Bonn, Germany. *Shared first authorship in alphabetical order. 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.09.03.280834;
    [Show full text]
  • ACNP 57Th Annual Meeting: Poster Session I
    www.nature.com/npp ABSTRACTS COLLECTION ACNP 57th Annual Meeting: Poster Session I Sponsorship Statement: Publication of this supplement is sponsored by the ACNP. Individual contributor disclosures may be found within the abstracts. Asterisks in the author lists indicate presenter of the abstract at the annual meeting. https://doi.org/10.1038/s41386-018-0266-7 M1. Lifespan Effects of Early Life Stress on Aging-Related Conclusions: These findings suggest a role for ELA in the form Trajectory of Memory Decline of poor maternal care in increasing the likelihood to development of peripheral IR, altered central glucocorticoid function and Benedetta Bigio*, Danielle Zelli, Timothy Lau, Paolo de Angelis, corresponding anxiety states in adulthood, and that these factors Daniella Miller, Jonathan Lai, Anisha Kalidindi, Susan Harvey, Anjali may encode lifelong susceptibility to pathophysiological aging. Ferris, Aleksander Mathe, Francis Lee, Natalie Rasgon, Bruce McEwen, Given our earlier reported association between IR and a LAC Carla Nasca deficiency, a candidate biomarker of major depression that is a risk factor for aging-associated memory decline, we are currently Rockefeller University, New York, New York, United States assessing LAC levels in this mechanistic framework. This model may provide endpoints for identification of early windows of opportunities for preemptive tailored interventions. Background: Early life adversities (ELA), such as variations in Keywords: Early Life Adversity, Glucocorticoids, Insulin Resis- maternal care of offspring, are critical factors underlying the tance, Glutamate, Memory Function individual likelihood to development of multiple psychiatric and Disclosure: Nothing to disclose. medical disorders. For example, our new translation findings suggest a role of ELA in the form of childhood trauma on fi development of metabolic dysfunction, such as a de ciency in M2.
    [Show full text]