ACNP 57Th Annual Meeting: Poster Session I
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Management of Large Sets of Image Data Capture, Databases, Image Processing, Storage, Visualization Karol Kozak
Management of large sets of image data Capture, Databases, Image Processing, Storage, Visualization Karol Kozak Download free books at Karol Kozak Management of large sets of image data Capture, Databases, Image Processing, Storage, Visualization Download free eBooks at bookboon.com 2 Management of large sets of image data: Capture, Databases, Image Processing, Storage, Visualization 1st edition © 2014 Karol Kozak & bookboon.com ISBN 978-87-403-0726-9 Download free eBooks at bookboon.com 3 Management of large sets of image data Contents Contents 1 Digital image 6 2 History of digital imaging 10 3 Amount of produced images – is it danger? 18 4 Digital image and privacy 20 5 Digital cameras 27 5.1 Methods of image capture 31 6 Image formats 33 7 Image Metadata – data about data 39 8 Interactive visualization (IV) 44 9 Basic of image processing 49 Download free eBooks at bookboon.com 4 Click on the ad to read more Management of large sets of image data Contents 10 Image Processing software 62 11 Image management and image databases 79 12 Operating system (os) and images 97 13 Graphics processing unit (GPU) 100 14 Storage and archive 101 15 Images in different disciplines 109 15.1 Microscopy 109 360° 15.2 Medical imaging 114 15.3 Astronomical images 117 15.4 Industrial imaging 360° 118 thinking. 16 Selection of best digital images 120 References: thinking. 124 360° thinking . 360° thinking. Discover the truth at www.deloitte.ca/careers Discover the truth at www.deloitte.ca/careers © Deloitte & Touche LLP and affiliated entities. Discover the truth at www.deloitte.ca/careers © Deloitte & Touche LLP and affiliated entities. -
FRIDAY LOCAL NEWS INSIDE ■ Charter Revision Meeting Set
V FRIDAY LOCAL NEWS INSIDE ■ Charter revision meeting set. ■ Chaiienger says debate avoided. W hat'S ■ Changes on horizon for schools. N ew s ■ Chamber supports renovations. Nov. 2,1990 Local/Regional Section, Page 7. Property owners oppose additions Preliminary tabulation of a Voted 1990 New Engiand Newspaper of the Year I, V^ur HometownHt Newspaper Newsstand Price: 35 Cents poll being taken of members of the Manchester Property Owners Association indicates 83 percent of the 50 people who have responded so far oppose a bond V T” issue of $11.1 million for an ad Recession said dition to town hall, and 86 per cent oppose bonding $3.9 mil lion for an addition to Manchester High School. to be imminent Betty Sadloski, president of the MPOA, announced the results this morning. By JOHN D. McCLAIN struction industries continued to She said responses are still The Associated Press slump. The index of leading in being received. dicators lags a month behind the un She said she has not yet tabu WASHINGTON — The govern employment report. lated the responses to four other ment’s chief economic forecasting Although last month’s civilian questions asked in the mailed gauge dropped 0.8 percent in Sep jobless rate was unchanged from survey, but she said it appears BY HIS FRIENDS YOU MAY KNOW HIM tember, the government said today, September’s 5.7 percent, the Labor that an even higher percentage \ for its second straight monthly drop. Department said the nation’s job of respondents feel that town ^pr The September drop followed a market continued to show weakness employees should be required to 1.2 percent plunge in August, the and widespread job losses. -
Accurate Segmentation of Brain MR Images
Accurate segmentation of brain MR images Master of Science Thesis in Biomedical Engineering ANTONIO REYES PORRAS PÉREZ Department of Signals and Systems Division of Biomedical Engineering CHALMERS UNIVERSITY OF TECHNOLOGY Göteborg, Sweden, 2010 Report No. EX028/2010 Abstract Full brain segmentation has been of significant interest throughout the years. Recently, many research groups worldwide have been looking into development of patient-specific electromagnetic models for dipole source location in EEG. To obtain this model, accurate segmentation of various tissues and sub-cortical structures is thus required. In this project, the performance of three of the most widely used software packages for brain segmentation has been analyzed: FSL, SPM and FreeSurfer. For the analysis, real images from a patient and a set of phantom images have been used in order to evaluate the performance r of each one of these tools. Keywords: dipole source location, brain, patient-specific model, image segmentation, FSL, SPM, FreeSurfer. Acknowledgements To my advisor, Antony, for his guidance through the project. To my partner, Koushyar, for all the days we have spent in the hospital helping each other. To the staff in Sahlgrenska hospital for their collaboration. To MedTech West for this opportunity to learn. Table of contents 1. Introduction ......................................................................................................................................... 1 2. Magnetic resonance imaging .............................................................................................................. -
Clinical Expertise and Patient Focus November, 2019
Clinical Expertise and Patient Focus November, 2019 1 Forward-Looking Statement Safe-Harbor This presentation contains forward-looking statements about Minerva whether any of our therapeutic products will advance further in the Neurosciences which are subject to the safe harbor provisions of the clinical trials process and whether and when, if at all, they will receive Private Securities Litigation Reform Act of 1995, as amended. Forward- final approval from the U.S. Food and Drug Administration or looking statements are statements that are not historical facts, reflect equivalent foreign regulatory agencies and for which indications; management’s expectations as of the date of this presentation, and whether the results of future clinical trials of roluperidone, seltorexant, involve certain risks and uncertainties. Forward-looking statements MIN-117 and MIN-301, if any, will be consistent with the results of past include, but are not limited to: the benefits, efficacy and safety of our clinical trials; whether roluperidone, seltorexant, MIN-117 and MIN-301 new formulations; the potential of the diagnosis and treatment of will be successfully marketed if approved; whether our therapeutic negative symptoms of schizophrenia and other diseases; whether product discovery and development efforts will be successful; our studies performed on analogs or backups of our compounds are a good ability to achieve the results contemplated by our co-development predictor of the clinical efficacy of our compounds; statements with agreements; the strength -
Freesurfer Tutorial
FreeSurfer Tutorial FreeSurfer is brought to you by the Martinos Center for Biomedical Imaging supported by NCRR/P41RR14075, Massachusetts General Hospital, Boston, MA USA 2008-06-01 20:47 1 FreeSurfer Tutorial Table of Contents Section Page Overview and course outline 3 Inspection of Freesurfer output 5 Troubleshooting your output 22 Fixing a bad skull strip 26 Making edits to the white matter 34 Correcting pial surfaces 46 Using control points to fix intensity normalization 50 Talairach registration 55 recon-all: morphometry and reconstruction 69 recon-all: process flow table 97 QDEC Group analysis 100 Group analysis: average subject, design matrix, mri_glmfit 125 Group analysis: visualization and inspection 149 Integrating FreeSurfer and FSL's FEAT 159 Exercise overview 172 Tkmedit reference 176 Tksurfer reference 211 Glossary 227 References 229 Acknowledgments 238 2008-06-01 20:47 2 top FreeSurfer Slides 1. Introduction to Freesurfer - Bruce Fischl 2. Anatomical Analysis with Freesurfer - Doug Greve 3. Surface-based Group Analysis - Doug Greve 4. Applying FreeSurfer Tools to FSL fMRI Analysis - Doug Greve FreeSurfer Tutorial Overview The FreeSurfer tools deal with two main types of data: volumetric data volumes of voxels and surface data polygons that tile a surface. This tutorial should familiarize you with FreeSurfer’s volume and surface processing streams, the recommended workflow to execute these, and many of their component tools. The tutorial also describes some of FreeSurfer's tools for registering volumetric datasets, performing group analysis on morphology data, and integrating FSL Feat output with FreeSurfer overlaying color coded parametric maps onto the cortical surface and visualizing plotted results. -
Confrontsred Tape
IPS: THE MENTAL HEALTH SERVICES CONFERENCE Oct. 8-11, 2015 • New York City When Good Care Confronts Red Tape Navigating the System for Our Patients and Our Practice New York, NY | Sheraton New York Times Square POSTER SESSION OCTOBER 09, 2015 POSTER SESSION 1 P1- 1 ANGIOEDEMA DUE TO POTENTIATING EFFECTS OF RITONIVIR ON RISPERIDONE: CASE REPORT Lead Author: Luisa S. Gonzalez, M.D. Co-Author(s): David A. Kasle MSIII Kavita Kothari M.D. SUMMARY: For many drugs, the liver is the principal site of its metabolism. The most important enzyme system of phase I metabolism is the cytochrome P-450 (CYP450). Ritonavir, a protease inhibitor used for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), has been shown to be a potent inhibitor of the (CYP450) 3A and 2D6 isozymes. This inhibition increases the chance for potential drug-drug interactions with compounds that are metabolized by these isoforms. Risperidone, a second generation atypical antipsychotic, is metabolized to a significant extent by the (CYP450) 2D6, and to a lesser extent 3A4. Ritonavir and risperidone can both cause serious, and even life threatening, side effects. An example of one such rare side effect is angioedema which is characterized by edema of the deep dermal and subcutaneous tissues. Here we present three cases of patients residing in a nursing home setting, diagnosed with HIV/AIDS and comorbid psychiatric illness. These patients were all on antiretroviral medications such as ritonavir, and all later presented with varying degrees of edema after long term use of risperidone. We aim to bring to awareness the potential for ritonavir inhibiting the metabolism of risperidone, thus leading to an increased incidence of angioedema in these patients. -
Minerva Neurosciences Announces the Results
Minerva Neurosciences Announces the Results of the Phase 3 Trial of Roluperidone for the Treatment of Negative Symptoms of Schizophrenia Following the Completion of the 40-Week Open-Label Extension May 11, 2021 Key results Continuous improvement in negative symptoms as measured by Positive and Negative Syndrome Scale (PANSS) Marder Negative Symptom Factor Score (NSFS) observed over one year (12-week double-blind and 40-week open-label periods) in patients receiving both 64 mg and 32 mg doses Continuous improvement in Personal and Social Performance (PSP) total score over one year, suggesting improvement in patients’ everyday life functioning Favorable safety profile with few serious adverse events and no evidence of somnolence, extrapyramidal side effects or weight gain Limited number of relapses observed over one year Results provide additional support for continued development of roluperidone and submission of NDA following completion of bioequivalence study and other work to address FDA comments from the Company’s Type C meeting held on November 10, 2020 Findings to be discussed during Q1 2021 conference call and webcast on May 12, 2021, at 8:30 a.m. WALTHAM, Mass., May 11, 2021 (GLOBE NEWSWIRE) -- Minerva Neurosciences, Inc. (Nasdaq: NERV), a clinical-stage biopharmaceutical company focused on the development of therapies to treat central nervous system disorders, today announced results from the 40-week open-label extension (OLE) of its phase 3 trial of roluperidone for the treatment of negative symptoms (NS) of schizophrenia. The OLE followed the 12-week double-blind, placebo-controlled portion of this trial. During the OLE, both investigators and patients were blinded to the roluperidone dose received (see “About the trial” below). -
Pharmacogenetics of Ketamine Metabolism And
Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine Yibai Li B.HSc. (Hons) Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide September 2014 A thesis submitted for the Degree of PhD (Medicine) Table of contents TABLE OF CONTENTS .............................................................................................. I LIST OF FIGURES ....................................................................................................IV LIST OF TABLES ......................................................................................................IV ABSTRACT ............................................................................................................... V DECLARATION .......................................................................................................VIII ACKNOWLEDGEMENTS ..........................................................................................IX ABBREVIATIONS .....................................................................................................XI CHAPTER 1. INTRODUCTION .................................................................................. 1 1.1 A historical overview of ketamine ........................................................................................ 1 1.2 Structure and Chemistry ....................................................................................................... 3 1.3 Classical analgesic mechanisms of ketamine ................................................................... -
Opioid Withdrawal ��������������������������������������������������������������������������������������������������� 15 Mark S
Magdalena Anitescu Honorio T. Benzon Mark S. Wallace Editors Challenging Cases and Complication Management in Pain Medicine 123 Challenging Cases and Complication Management in Pain Medicine Magdalena Anitescu Honorio T. Benzon • Mark S. Wallace Editors Challenging Cases and Complication Management in Pain Medicine Editors Magdalena Anitescu Honorio T. Benzon Department of Anesthesia and Critical Care Department of Anesthesiology University of Chicago Medicine Northwestern University Chicago, IL Feinberg School of Medicine USA Chicago, IL USA Mark S. Wallace Division of Pain Medicine Department of Anesthesiology University of California San Diego School of Medicine La Jolla, CL USA ISBN 978-3-319-60070-3 ISBN 978-3-319-60072-7 (eBook) https://doi.org/10.1007/978-3-319-60072-7 Library of Congress Control Number: 2017960332 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. -
Question of the Day Archives: Monday, December 5, 2016 Question: Calcium Oxalate Is a Widespread Toxin Found in Many Species of Plants
Question Of the Day Archives: Monday, December 5, 2016 Question: Calcium oxalate is a widespread toxin found in many species of plants. What is the needle shaped crystal containing calcium oxalate called and what is the compilation of these structures known as? Answer: The needle shaped plant-based crystals containing calcium oxalate are known as raphides. A compilation of raphides forms the structure known as an idioblast. (Lim CS et al. Atlas of select poisonous plants and mushrooms. 2016 Disease-a-Month 62(3):37-66) Friday, December 2, 2016 Question: Which oral chelating agent has been reported to cause transient increases in plasma ALT activity in some patients as well as rare instances of mucocutaneous skin reactions? Answer: Orally administered dimercaptosuccinic acid (DMSA) has been reported to cause transient increases in ALT activity as well as rare instances of mucocutaneous skin reactions. (Bradberry S et al. Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. 2009 Q J Med 102:721-732) Thursday, December 1, 2016 Question: What is Clioquinol and why was it withdrawn from the market during the 1970s? Answer: According to the cited reference, “Between the 1950s and 1970s Clioquinol was used to treat and prevent intestinal parasitic disease [intestinal amebiasis].” “In the early 1970s Clioquinol was withdrawn from the market as an oral agent due to an association with sub-acute myelo-optic neuropathy (SMON) in Japanese patients. SMON is a syndrome that involves sensory and motor disturbances in the lower limbs as well as visual changes that are due to symmetrical demyelination of the lateral and posterior funiculi of the spinal cord, optic nerve, and peripheral nerves. -
“Indagandis Sedibus Et Causis Morborum” Potential Conflicts of Interest (January 2016 to Present)
Siegfried KASPER Emeritus Chair Department of Psychiatry and Psychotherapy Brain Research Institute “Indagandis sedibus et causis morborum” www.mghcme.org Potential Conflicts of Interest (January 2016 to Present) Dr. Kasper has received grant/research support from Lundbeck; he has served as a consultant or on advisory boards for Janssen, Lundbeck, and Schwabe; and he has served on speakers bureaus for Angelini, Krka Pharma, Lundbeck, Neuraxpharma, Schwabe, Servier and Sun Pharma. www.mghcme.org Schizophrenias Are Multifactorial Diseases Rujescu, 2019 www.mghcme.org Schizophrenia: Course of illness Millan et al., Nat Rev Drug Discov 2016 www.mghcme.org Schizophrenia: Impact of Symptomatology Work Quality of Social life Function Positive Symptoms Negative Symptoms o Hallucination o Blunted affect o Delusion o Anhedonia o Catatonia o Sozcial withdrawn o … o Etc… Number of Side Relapses Effects Cognitive Symptoms Affective Symptoms o Working Memory o Anxiety and Stress o Processing Speed o Depression Mortality Attention Suicidality Life o o Expectancy o … o … Response Remission Recovery www.mghcme.org Selecting Suitable Treatments for Schizophrenia Can Pose a Dilemma for Psychiatrists In selecting treatments for schizophrenia, physicians consider variables related to the:1,2 Patient Illness Medication Environment An ‘ideal’ medication is one that can:2 • Treat psychosis • Lead to symptom resolution The dilemma for physicians: • Lead to remission providing effective treatment while 3 • Overcome treatment resistance avoiding side effects • Prevent relapse • Have a benign side-effect profile The need to assess how side effects • Alleviate anxiety and depression interact with the patient’s life4-6 1. Kane et al. Dialogues Clin Neurosci 2010;12(3):345–357 2. -
A Novel Mricompatible Brain Ventricle Phantom for Validation of Segmentation and Volumetry Methods
CME JOURNAL OF MAGNETIC RESONANCE IMAGING 36:476–482 (2012) Original Research A Novel MRI-Compatible Brain Ventricle Phantom for Validation of Segmentation and Volumetry Methods Amanda F. Khan, MSc,1,2 John J. Drozd, PhD,2 Robert K. Moreland, MSc,2,3 Robert M. Ta, MSc,1,2 Michael J. Borrie, MB ChB,3,4 Robert Bartha, PhD1,2* and the Alzheimer’s Disease Neuroimaging Initiative Purpose: To create a standardized, MRI-compatible, life- Conclusion: The phantom represents a simple, realistic sized phantom of the brain ventricles to evaluate ventricle and objective method to test the accuracy of lateral ventri- segmentation methods using T1-weighted MRI. An objec- cle segmentation methods and we project it can be tive phantom is needed to test the many different segmen- extended to other anatomical structures. tation programs currently used to measure ventricle vol- Key Words: 3T; brain phantom; MRI; ventricle; software umes in patients with Alzheimer’s disease. validation; segmentation Materials and Methods: A ventricle model was con- J. Magn. Reson. Imaging 2012;36:476–482. structed from polycarbonate using a digital mesh of the VC 2012 Wiley Periodicals, Inc. ventricles created from the 3 Tesla (T) MRI of a subject with Alzheimer’s disease. The ventricle was placed in a brain mold and surrounded with material composed of VOLUMETRY HAS DEMONSTRATED that large mor- 2% agar in water, 0.01% NaCl and 0.0375 mM gadopente- phological changes occur in the brain during the tate dimeglumine to match the signal intensity properties course of Alzheimer’s disease (AD) (1). In particular, of brain tissue in 3T T -weighted MRI.