US 20090263516A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0263516 A1 CYR (43) Pub. Date: Oct. 22, 2009

(54) PLANT EXTRACT COMPOSITION AND Publication Classification THEIR USE TO MODULATE CELLULAR (51) Int. Cl. ACTIVITY A636/8962 (2006.01) A636/00 (2006.01) (75) Inventor: Benoit CYR, St. Augustin de A6IP35/00 (2006.01) Desmaures (CA) CI2N 5/06 (2006.01) Correspondence Address: A6IR 36/3 (2006.01) SHEPPARD, MULLIN, RICHTER & HAMPTON A 6LX 36/899 (2006.01) LLP (52) U.S. Cl...... 424/754; 424/725; 435/375; 424/774; 990 Marsh Road 424/779; 424/755; 424/750; 424/777 Menlo Park, CA 94025 (US) (57) ABSTRACT (73) Assignee: Biopharmacopae Design Extracts from plant material, or semi-purified/purified mol International Inc., Saint-Foy (CA) ecules or compounds prepared from the extracts that demon strate the ability to modulate one or more cellular activities (21) Appl. No.: 12/263,114 are provided. The extracts are capable of slowing down, inhibiting or preventing cell migration, for example, the (22) Filed: Oct. 31, 2008 migration of endothelial cells or neoplastic cells and thus, the use of the extracts to slow down, inhibit or prevent abnormal Related U.S. Application Data cell migration in an animal is also provided. Methods of selecting and preparing the plant extracts and methods of (63) Continuation of application No. 10/526,387, filed on screening the extracts to determine their ability to modulate Oct. 6, 2005, now abandoned, filed as application No. one or more cellular activity are described. The purification or PCT/CA03/01284 on Sep. 2, 2003. semi-purification of one or more molecules from the described extracts is also contemplated as well as the use of (30) Foreign Application Priority Data these molecules, alone or in combination with an extract, to slow down, inhibit or prevent abnormal cell migration in an Aug. 30, 2002 (CA) ...... 24OO 936 animal.

our

Treatment

---...------orasaraws were rary r Contact Solid S1 with Solvent.A Extraction Process Separate Pre-Extract. A from Solid MatterS2

Extraction Process Separate Pre-Extract B Potential Pre-ExtractB from Solid Matter S3 contact Solid S3 with : SolventC ExtractionProcess Separate Pre-Extract C Potential Pre-Extract C from Solid Matter S4

Patent Application Publication Oct. 22, 2009 Sheet 1 of 5 US 2009/0263516 A1

FIGURE 1

Potential Plant reherePre-Harvesthecarerearn seas Treatment Harvest Solid S1

Optional Storage Treatment

s as a ------27------as a reseae as or per - our an a soapa - as a son an a-ana -- - -

s Contact Solid S1 with Solvent A

Extraction Process I

s y Separate Pre-Extract A 0. from Solid Matter S2 Potential Pre-Extract A

Contact Solid S2 with Solvent B Extraction Process II Separate Pre-Extract B PPotential Pre-Extract B from Solid Matter S3

sea n e s so was a ------a is an as an up a us v wear - a as a uses as us r as sar or a sur use - - Contact Solid S3 with Solvent C Extraction Process III Separateare:-coastEs Pre-Extract C Potential(P Pre-Extractic- Solid S4 Patent Application Publication Oct. 22, 2009 Sheet 2 of 5 US 2009/0263516 A1

FIGURE 2

Potential Pre-Extract

Separation Procedure(s)

Potential Extract

Test Aliquots against panel of 2 or more Extracellular Proteases

Does Extract demonstrate inhibitory Potential Extract is an • Inconclusive activity against one or Extract of the more extracellular avention proteases?

Potential Extract is not an Extract of the Invention

Plant remains a Potential Plant

Entire Procedure may be repeated on Potential Plant under varied conditions Patent Application Publication Oct. 22, 2009 Sheet 3 of 5 US 2009/0263516 A1

FIGURE 3

One or More Plants of the Invention

Pre-Harvest Treatinent

Harvest Solid S1

Optional Storage Treatment

Extraction Process I, II o Process may be sequentially repeated

- Purification Procedure(s)

Qualityonly aControlcore --

Extract Demonstrating Inhibitory Activity Against One or More Extracellular Proteases

Prepare Formulation for Use Patent Application Publication Oct. 22, 2009 Sheet 4 of 5 US 2009/0263516 A1

Figure 4

Patent Application Publication Oct. 22, 2009 Sheet 5 of 5 US 2009/0263516 A1

Figure 5

US 2009/0263516 A1 Oct. 22, 2009

PLANT EXTRACT COMPOSITION AND 0007. The regulated turnover of extracellular matrix mac THEIR USE TO MODULATE CELLULAR romolecules is critical to a variety of important biological ACTIVITY processes. Localised degradation of matrix components is required when cells migrate through a basal lamina, as when CROSS-REFERENCE TO RELATED white blood cells migrate across the vascular basal lamina APPLICATION into tissues in response to infection or injury, or when cancer cells migrate from their site of origin to distant organs via the 0001. This application is a continuation of U.S. patent bloodstream or lymphatic vessels, during metastasis. In nor application Ser. No. 10/526,387 filed on Oct. 6, 2005, which mal tissues, the activity of extracellular proteases is tightly claims the benefit under 35 U.S.C. S.371 to PCT Application regulated and the breakdown/production of connective tissue No. PCT/CA2003/001284 filed on Sep. 2, 2003, which is in dynamic equilibrium, Such that there is a slow and claims priority to Canadian Application No. 2,400.936, filed continual turnover due to degradation and resynthesis in the on Aug. 30, 2002, all of which are incorporated herein in their extracellular matrix of adult animals. entireties. 0008. In each of these cases, matrix components are FIELD OF INVENTION degraded by extracellular proteolytic enzymes that are secreted locally by cells. These proteases belong to one of 0002 The invention pertains to the field of modulators of four general classes: many are metalloproteinases, which cellular activity, specifically within the field of inhibitors of depend on bound Ca" or Zn" for activity, while the others extracellular proteases. are serine, aspartic and cysteine proteases, which have a highly reactive serine, aspartate or cysteine residue in their BACKGROUND OF THE INVENTION respective active site (Vincenti et al., (1994) Arthritis and 0003. The cells of tissues are generally in contact with a Rheumatism, 37: 1115-1126). Together, metalloproteinases, network of large extracellular macromolecules that occupies serine, aspartate and cysteine proteases cooperate to degrade the spaces in a tissue between the component cells and also matrix proteins such as collagen, laminin, and fibronectin. occupies the space between adjacent tissues. This extracellu 0009. Several mechanisms operate to ensure that the deg lar matrix functions as a scaffolding on which the cells and radation of matrix components is tightly controlled. First, tissue are Supported and is involved actively in regulating many proteases are secreted as inactive precursors that can be interaction of the cells that contact it. The principal macro activated locally. Second, the action of proteases is confined molecules of the extracellular matrix include the collagens to specific areas by various secreted protease inhibitors, such (the most abundant proteins in the body) and glycosami as the tissue inhibitors of metalloproteases and the serine noglycans (complex polysaccharides which are usually protease inhibitors known as serpins. These inhibitors are bonded also to protein and then termed proteoglycans). The specific for particular proteases and bind tightly to the acti macromolecules that comprise the extracellular matrix are vated enzyme to block its activity. Third, many cells have produced typically by the cells in contact therewith, for receptors on their surface that bind proteases, thereby confin example, epithelial cells in contact with a basement mem ing the enzyme to where it is needed. brane and fibroblasts embedded in connective tissue. 0010 Many pathogenic bacteria produce extracellular 0004 The glycosaminoglycan (proteoglycan) molecules metalloproteases, of which many are Zinc containing pro form a highly hydrated matrix (a gel) in which elastic or teases that can be classified into two families, the thermolysin fibrous proteins (such as collagen fibres) are embedded. The (neutral) proteases and the serralysin (alkaline) proteases. aqueous nature of the gel permits diffusion of metabolically 0011. A number of patents and publications report the required substances between the cells of a tissue and between inhibition of one or more extracellular proteases by com tissues. Additional proteins that may be found in extracellular pounds extracted from plants. For example, Sun et al., (1996) matrix include elastin, fibronectin and laminin. Phytotherapy Res., 10: 194-197, reports the inhibition invitro 0005. The term “connective tissue' refers to extracellular of stromelysin (MMP-3) and collagenase by betulinic acid matrix plus specialised cells Such as, for example, fibroblasts, extracted from Doliocarpus verruculosis. SaZuka et al. chondrocytes, osteoblasts, macrophages and mast cells found (1997) Biosci. Biotechnol. Biochem., 61: 1504-1506, reports therein. The term “interstitial tissue' is best reserved for an the inhibition of gelatinases (MMP-2 and MMP-9) and extracellular matrix that stabilises a tissue internally, filling metastasis by compounds isolated from green and black teas. the gaps between the cells thereof. There are also specialised Kumagai et al., JP 08104628 A2, Apr. 1, 1996 (CA 125: forms of extracellular matrix (connective tissue) that have 67741) reports the use of flavones and anthocyanines isolated additional functional roles-cornea, cartilage and tendon, and from Scutellaris baicanlensis roots to inhibit collagenase. when calcified, the bones and teeth. Gervasi et al., (1996) Biochem. Biophys. Res. Comm., 228: 0006. A structural form of extracellular matrix is the basal 530-538, reports the regulation of MMP-2 by some plant lamina (basement membrane). Basal laminae are thin Zones lectins and other saccharides. Dubois et al., (1998) FEBS of extracellular matrix that are found under epithelium or Lett., 427: 275-278, reports the increased secretion of delete Surrounding, for example, muscle cells or the cells that elec rious gelatinase-B (MMP-9) by some plant lectins. Nagase et trically insulate nerve fibres. Generally speaking, basal lami al., (1998) Planta Med., 64: 216-219, reports the weak inhi nae separate cell layers from underlying Zones of connective bition of collagenase (MMPs) by delphinidin, a flavonoid tissue or serve as a boundary between two cell layers wherein isolated from Solanum melongena. Other reports discuss the a basal lamina can serve as a pathway for invading cells use of extracts to inhibit extracellular proteases. For example, associated with pathologic processes, or for structural organi Asano et al., (1998) Immunopharmacology, 39: 117-126, sation associated with tissue repair (i.e. as a blueprint from reports the inhibition of TNF-C. production using Triptery which to regenerate original tissue architecture and morphol gium wilfordii Hook F. extracts. Maheu et al., (1998) Arthritis ogy). Rheumatol., 41: 81-91, reports the use of avocado/soybean US 2009/0263516 A1 Oct. 22, 2009

non-Saponifiable extracts in the treatment of arthritis. 0018. In accordance with another aspect of the present Makimura et al., (1993) J. Periodontol., 64: 630-636, also invention, there is provided a sub-library of plant extracts, reports the use of green tea extracts to inhibit collagenases in said Sub-library being prepared by a process comprising: vitro. Obayashi et al., (1998) Nippon Keshonin Gijutsusha 0019 (a) harvesting plant material from selected plants; Kaishi, 32: 272-279 (CA 130: 92196) reports the inhibition of collagenase-I (MMP-1) from human fibroblast and neutro 0020 (b) contacting said plant material with a solvent to phil elastase by plant extract from Eucalyptus and Elder. provide a plurality of potential extracts; 0012. When a plant is stressed, several biochemical pro 0021 (c) analysing each potential extract for inhibitory cesses are activated and many new chemicals, in addition to activity against at least one extracellular protease; those constitutively expressed, are synthesised as a response. 0022 (d) selecting those potential extracts that are capable These chemicals include enzymes, enzyme inhibitors (espe of inhibiting the activity of at least one extracellular pro cially protease inhibitors), lectins, alkaloids, terpenes, oli tease to provide a library of extracts; gosaccharides, and antibiotics. The biosynthesis of these defense chemicals and secondary metabolites is not yet fully 0023 (e) analysing the ability of each extract in said understood. The most studied system is the production of library to slow down migration of endothelial or neoplastic protease inhibitors following pest attack or mechanical cells in vitro, and wounding. On the other hand, several inducible chemicals are 0024 (f) selecting those extracts that are capable of slow the products of complex biochemical pathways, which ing down migration of said endothelial or neoplastic cells require several biosynthetic enzymes to be activated. to provide a sub-library of plant extracts. 0013. It has been shown that many chemicals can be used 0025. In accordance with another aspect of the present to “stress' plants and to artificially stimulate biosynthesis of invention, there is provided a pharmaceutical composition several new and constitutive defense chemicals. Also, differ comprising a plant extract of the invention and a pharmaceu ent types of stress can activate distinct metabolic defense tically acceptable diluent, excipient or carrier. pathways, thereby leading to production of a variety of 0026. In accordance with another aspect of the present chemicals. Although the various biosynthetic defense path invention, there is provided a use of a plant extract of the ways share some similarities, these pathways are character invention to slow down, inhibit or prevent angiogenesis in an istic of specific plant species. Therefore, treating many plants animal in need thereof. with many types of stress can lead to a vast number of col lections of diverse chemicals from plant origin. 0027. In accordance with another aspect of the present 0014. In addition to pests, fungi, and other pathogenic invention, there is provided a use of a plant extract of the attacks, stressors include drought, heat, water and mechanical invention to slow down, inhibit or prevent metastasis in an wounding. Furthermore, many chemicals can act as stressors animal in need thereof. that activate gene expression; these include: hydrogen peroX 0028. In accordance with another aspect of the present ide, oZone, Sodium chloride, jasmonic acid and derivatives, invention, there is provided a use of a plant extract of the O-linoleic acid, Y-linoleic acid, salicylic acid, abscesic acid, invention in the manufacture of a medicament. Volicitin, Small oligopeptides, among others. 0029. In accordance with another aspect of the present 0015 The use of abiotic stressors on plants has been the invention, there is provided a use of a plant extract to slow focus of intense studies in plant science. Artificial stresses down cell migration in an animal in need thereof, wherein have been used to stimulate the production of natural plant said plant extract inhibits the activity of at least one extracel protease inhibitors for insect digestive proteases, in order to lular protease and has at least one of the following properties: enhance crop protection against certain pests and herbivores. (i) is capable of slowing down or inhibiting migration of They have proven useful in combination with plants geneti endothelial cells, and (ii) is capable of slowing down or inhib cally modified to express other protease inhibitor genes. iting migration of neoplastic cells. Finally, in the area of molecular farming, stresses have been 0030. In accordance with another aspect of the present used to stimulate gene expression in plants genetically modi invention, there is provided a process for preparing a Sub fied to include an inducible coding sequence for a protein of library of plant extracts that are capable of slowing down or nutraceutical and/or medicinal interest (Ryan and Farmer, inhibiting cell migration, said process comprising: U.S. Pat. No. 5,935,809). (a) harvesting plant material from selected plants; 0016. Likewise, the use of gene activators or elicitors have 0.031 been described to enhance the production of volatile chemi 0032 (b) contacting said plant material with a solvent to cals in plant cell cultures. These elicitors have been demon provide a plurality of potential extracts; strated to induce the activity of several enzymes such as for 0033 (c) analysing each potential extract for inhibitory example phenylalanine ammonia lyase, therefore leading to activity against at least one extracellular protease; an increase in the production of plant Volatile components. 0034 (d) selecting those potential extracts that are capable of inhibiting the activity of at least one extracellular pro SUMMARY OF THE INVENTION tease provide a library of extracts; 0017. An object of the invention is to provide plant extract 0035 (e) analysing the ability of each extract in said compositions and their use to modulate cellular activity. In library to slow down migration of endothelial or neoplastic accordance with one aspect of the present invention, there is cells in vitro, and provided a plant extract that inhibits the activity of at least one 0036 (f) selecting those extracts that are capable of slow extracellular protease, said extract having at least one of the ing down migration of said endothelial or neoplastic cells following properties: (i) is capable of slowing down or inhib to provide a sub-library of plant extracts. iting migration of endothelial cells, and (ii) is capable of 0037. In accordance with another aspect of the present slowing down or inhibiting migration of neoplastic cells. invention, there is provided a process for identifying a plant US 2009/0263516 A1 Oct. 22, 2009

extract capable of inhibiting cell migration, said process com fied/purified molecules, alone or in combination with an prising: extract, to slow down, inhibit or prevent abnormal cell migra 0038 (a) harvesting plant material from a selected plants; tion in an animal. 0039 (b) contacting said plant material with a solvent to provide a plurality of potential extracts; DEFINITIONS 0040 (c) analysing each potential extract for inhibitory 0.052 Unless defined otherwise, all technical and scien activity against at least one extracellular protease; tific terms used herein have the same meaning as commonly 0041 (d) selecting those potential extracts that are capable understood by one of ordinary skill in the art to which this of inhibiting the activity of at least one extracellular pro invention belongs. tease provide a library of plant extracts; 0053. The term “potential plants, as used herein, is 0042 (e) analysing the ability of each plant extract in said intended to include all species of the Kingdom Plantae, library to slow down migration of endothelial or neoplastic including terrestrial, aquatic or other plants under the Divi sion Chlorophyta, Division Rhodophora, Division Paeo cells in vitro, and phyta, Division Bryophyta and Division Tracheophyta; Sub 0043 (f) selecting a plant extract that is capable of slowing division Lycopsida, Subdivision Sphenopsida, Subdivision down migration of said endothelial or neoplastic cells. Pteropsida and Subdivision Spermopsida; Class Gymnosper 0044. In accordance with another aspect of the present mae, Class Angiospermae, Subclass Dicotyledonidae and invention, there is provided a plant extract produced by the Subclass Monocotyledonidae. In general terms, all plants, above process. herbs, and lowerplants such as fungi and algae are considered to be potential plants in accordance with the present inven BRIEF DESCRIPTION OF THE FIGURES tion. 0054 The term “plant material.” as used herein, refers to 0045 FIG. 1 presents an overview of a procedure that can any part or parts of a plant taken either individually or in a be followed in one embodiment of the invention in order to group. Examples include, but are not limited to, leaves, flow generate plant extracts, each of which is derived from Solid ers, roots, seeds, stems, and other part of a plant, including plant material. those plants described herein as potential plants of the inven 0046 FIG. 2 describes in further detail, a procedure that tion. can be followed in one embodiment of the invention in order 0055. The term “extracellular protease.” as used herein, to generate the extracts of the invention. refers to an enzyme that is capable of degrading proteins (i.e. 0047 FIG. 3 presents an overview of a commercial pro proteolysis) and which is secreted outside the cell. The cell cedure that can be followed in one embodiment of the inven can be prokaryotic or eukaryotic. Examples of extracellular tion in order to prepare extracts of the invention. proteases include, but are not limited to, matrix metallopro teases (MMPs), cathepsins, elastase, plasmin, TPA, uPA, kal 0048 FIG. 4 (a) untreated control cells; (b) show cells likrein, ADAMS family members, neprilysin, gingipain, treated with an extract of the present invention having a clostripain, thermolysin, serralysin, and other bacterial and concentration of 0.5x; (c) shows cells treated with an extract viral proteases. of the present invention having a concentration of 1x. 0056. The term “panel of extracellular proteases.” refers to 0049 FIG.5 (a) shows untreated cells; (b) shows cells plus an array of distinct extracellular proteases that are used to a positive control; (c) shows cells treated with an extract of the perform routine assays to monitor the presence or absence of present invention having a concentration of 1x; (d) shows inhibitory activity throughout an extraction process of the cells treated with an extract of the present invention having a invention. A panel typically comprises at least two proteases, concentration of 2x. but may for Some purposes comprise as few as one protease. One skilled in the art would appreciate that as high throughput DETAILED DESCRIPTION OF THE INVENTION screening techniques develop, one could routinely assay for the presence or absence of inhibitory activity against as many 0050. The present invention provides for extracts from extracellular proteases as the technology permits. plant material, or semi-purified/purified molecules or com 0057 The term “potential pre-extract,” refers to refers to a pounds prepared from the extracts, that are capable of inhib composition prepared by contacting a solvent with plant iting one or more extracellular protease and that demonstrate material following the procedures described herein, which the ability to modulate one or more cellular activities. In one has not yet been determined to possess inhibitory activity embodiment of the invention the extracts are capable of slow against one or more extracellular protease. ing down, inhibiting or preventing cell migration, for 0058. The term “potential extract as used herein, refers to example, the migration of endothelial cells or neoplastic a potential pre-extract that has been Subjected to one or more cells. The present invention also provides for the use of the separation and/or purification step. extracts to slow down, inhibit or prevent abnormal cell migra 0059. The term “extract of the invention, as used herein, tion in an animal, and thus can be used, for example, in the refers to a composition prepared by contacting a solvent with alleviation of conditions where there is a need to slow down plant material following the procedures described herein, angiogenesis or neoplastic cell invasion. which demonstrates inhibitory activity against one or more 0051. The present invention further provides for methods extracellular protease and demonstrates an ability to modu of selecting and preparing the plant extracts and for methods late one or more cellular activity. ofscreening the extracts to determine their ability to modulate 0060. The term “protease inhibitor,” as used herein, refers one or more cellular activity. The invention additionally pro to a molecule or compound that attenuates the proteolytic vides for the purification or semi-purification of one or more activity of proteases. A protease inhibitor may or may not be molecules from the extract and for the use of the semi-puri proteinaceous. US 2009/0263516 A1 Oct. 22, 2009

0061. The term “stressor,” as used herein, refers to a factor, or Pre-Extract B. Finally, the solid S3 is treated with the third Such as a physical stress, a chemical compound, or a biologi solvent and the liquid from this treatment is separated from cal agent that is used to elicit production of extracellular the solid material (solid S4). protease inhibitors as a result of activation of a defense response in a plant. Elicitors and inducers are also considered Plant Material to be stressors. 0.066 Plant material suitable for use in preparing an 0062. The term “substantially purified’ or “substantially extract of the invention is derived from a “potential plant.” pure' or “isolated, when used in reference to a molecule or Potential plants include all species of the Kingdom Plantae, molecules having protease inhibitor activity, refers to a form including terrestrial, aquatic or other plants that can be Sub of the molecule(s) that is relatively free of proteins, nucleic jected to the methodology described herein in order to gen acids, lipids, carbohydrates or other materials with which it is erate an extract that can be tested against a panel of extracel naturally associated in a plant. As disclosed herein, a plant lular proteases. Those plants which yield an extract extract of the invention is considered to be substantially puri demonstrating inhibitory activity againstan extracellular pro fied, in that it is removed from the plant tissue from which it is derived. In addition, molecules or compounds having pro tease and an ability to modulate cellular activity are consid tease inhibitor activity that are present within the extract can ered to be plants and extracts comprising the Subject matter of be further purified using routine and well-known methods the invention. Such as those described herein. As such, a Substantially pure 0067 Examples of potential plants include, but are not protease inhibitor of the invention can constitute at least about limited to, those belonging to the following classifications: one or a few percent of a sample, for example, at least about Superdivision Spermatophyta. Seed plants; Division Conif five percent of a sample. In one embodiment, the Substantially erophyta Conifers; Class Pinopsida, Order Pinales; Family pure protease inhibitor constitutes at least about twenty per Araucariaceae—Araucaria family; Family Cephalotax cent of a sample. In another embodiment, the protease inhibi aceae Plum Yew family; Family Cupressaceae Cypress tor can be further purified to constitute at least about fifty family; Family Pinaceae Pine family; Family Podocar percent of a sample. In a further embodiment, the protease paceae-Podocarpus family; Family Taxodiaceae Red inhibitor can be further purified to constitute at least about wood family; Order Taxales, Family Taxaceae Yew family; eighty percent of a sample. In other embodiments, the pro Division Cycadophyta Cycads, Class Cycadopsida, Order tease inhibitor can be further purified to constitute at least Cycadales, Family Cycadaceae Cycad family; Family about ninety percent or at least about ninety-five percent or Zamiaceae—Sago-palm family: Division Ginkgophyta more of a sample. A determination that a protease inhibitor of Ginkgo, Class Ginkgoopsida, Order Ginkgoales, Family the invention is Substantially pure can be made using methods Ginkgoaceae-Ginkgo family: Division Gnetophyta Mor Such as those disclosed herein or otherwise known in the art, mon tea and other gnetophytes, Class Gnetopsida, Order for example, by performing electrophoresis and identifying Ephedrales, Family Ephedraceae Mormon-tea family; Order Gnetales, Family Gnetaceae Gnetum family: Divi the particular molecule as a relatively discrete band. sion Magnoliophyta-Flowering plants, Class Liliopsida— 0063. The term “cell migration, as used herein, refers to Monocotyledons, Subclass Alismatidae, Order Alismatales, the movement, typically abnormal, of a cell or cells from one Family Alismataceae Water-plantain family, Family locus to another. Examples of cell migration include the Butomaceae Flowering Rush family, Family Limnochari movement of cells through the extracellular matrix and/or taceae Water-poppy family; Order Hydrocharitales, Family basal lamina during angiogenesis or cell invasion. Hydrocharitaceae Tape-grass family; Order Najadales, 0064. Other chemistry terms herein are used according to Family Aponogetonaceae—Cape-pondweed family, Family conventional usage in the art, as exemplified by The McGraw Cymodoceaceae—Manatee-grass family, Family Juncagi Hill Dictionary of Chemical Terms (ed. Parker, S., 1985), naceae—Arrow-grass family, Family Najadaceae Water McGraw-Hill, San Francisco, incorporated herein by refer nymph family, Family Posidoniaceae—Posidonia family, ence). Family Potamogetonaceae Pondweed family, Family Rup piaceae-Ditch-grass family, Family ScheuchZeriaceae— Preparation of Plant Extracts Scheuchzeria family, Family Zannichelliaceae Horned 0065. With reference to FIG. 1, one embodiment of the pondweed family, Family Zosteraceae—Eel-grass family; present invention provides a process for producing an extract Subclass Arecidae, Order Arales, Family Acoraceae Cala of the invention that begins with the selection of a plant mus family, Family Araceae—Arum family, Family Lem species. Once the plant species has been chosen, a pre-harvest naceae Duckweed family; Order Arecales, Family treatment is selected, for example treatment with water, or Arecaceae Palm family; Order Cyclanthales, Family treatment with water in addition to a stressor or a combination Cyclanthaceae Panama Hat family; Order Pandanales, of stressors. The stress can be applied separately from the Family Pandanaceae Screw-pine family; Subclass Comme water (if the stress is drought, then the water would not be linidae, Order Commelinales, Family Commelinaceae Spi provided for the period in which the plant is to be stressed) or derwort family, Family Mayacaceae—Mayaca family, Fam concomitantly. The next step of the process involves choosing ily Xyridaceae Yellow-eyed Grass family; Order whether the treated plant will be treated for storage and stored Cyperales, Family Cyperaceae-Sedge family, Family prior to contacting plant material with the first solvent or Poaceae Grass family; Order Eriocaulales, Family Erio whether it will be used directly. The plant material is next caulaceae Pipewort family; Order Juncales, Family Jun treated with the first solvent after which the liquid is separated caceae Rush family; Order Restionales, Family Joinvil from the solid material (solid S2), wherein the liquid becomes leaceae Joinvillea family; Order Typhales, Family Fraction F1 or Pre-Extract A. The Solid S2 is treated with the Sparganiaceae—Bur-reed family, Family Typhaceae—Cat second solvent and the liquid is again separated from the Solid tail family; Subclass Liliidae, Order Liliales, Family Aga material (solid S3), wherein the liquid becomes Fraction F2 vaceae Century-plant family, Family Aloeaceae—Aloe US 2009/0263516 A1 Oct. 22, 2009 family, Family Dioscoreaceae Yam family, Family Haemo Dilleniaceae Dillenia family, Family Paeoniaceae Peony doraceae—Bloodwort family, Family Hanguanaceae— family; Order Ebenales, Family Ebenaceae Ebony family, Hanguana family, Family Iridaceae—Iris family, Family Lili Family Sapotaceae Sapodilla family, Family Styra aceae Lily family, Family Philydraceae Philydraceae caceae Storax family, Family Symplocaceae—Sweetleaf family, Family Pontederiaceae Water-Hyacinth family, family; Order Ericales, Family Clethraceae Clethra family, Family Smilacaceae Catbrier family, Family Stemo Family Cyrillaceae Cyrilla family, Family Empetraceae— naceae-Stemona family, Family Taccaceae Tacca family; Crowberry family, Family Epacridaceae Epacris family, Order Orchidales, Family Burmanniaceae Burmannia fam Family Ericaceae—Heath family, Family Monotropaceae— ily, Family Orchidaceae Orchid family; Subclass Zingib Indian Pipe family, Family Pyrolaceae Shinleaf family; eridae, Order Bromeliales, Family Bromeliaceae Brome Order Lecythidales, Family Lecythidaceae Brazil-nut fam liad family; Order Zingiberales, Family Cannaceae—Canna ily; Order Malvales, Family Bombacaceae Kapok-tree family, Family Costaceae Costus family, Family Heliconi family, Family Elaeocarpaceae—Elaeocarpus family, Family aceae-Heliconia family, Family Marantaceae—Prayer Malvaceae Mallow family, Family Sterculiaceae Cacao Plant family, Family Musaceae Banana family, Family Zin family, Family Tiliaceae—Linden family; Order Nepentha giberaceae-Ginger family: Class Magnoliopsida— les, Family Droseraceae Sundew family, Family Dicotyledons, Subclass Asteridae, Order Asterales, Family Nepenthaceae East Indian Pitcher-plant family, Family Asteraceae Aster family; Order Callitrichales, Family Cal Sarraceniaceae Pitcher-plant family; Order Primulales, litrichaceae Water-starwort family, Family Hippuri Family Myrsinaceae Myrsine family, Family Primu daceae Mare's-tail family; Order Calycerales, Family laceae Primrose family, Family Theophrastaceae. Theo Calyceraceae-Calycera family; Order Campanulales, Fam phrasta family; Order Salicales, Family Salicaceae Willow ily Campanulaceae Bellflower family, Family Goodeni family; Order Theales, Family Actinidiaceae Chinese aceae—Goodenia family, Family Sphenocleaceae—Speno Gooseberry family, Family Caryocaraceae-Souari family, clea family; Order Dipsacales, Family Adoxaceae— Family Clusiaceae—Mangosteen family, Family Dipterocar Moschatel family, Family Caprifoliaceae Honeysuckle paceae Meranti family, Family Elatinaceae Waterwort family, Family Dipsacaceae Teasel family, Family Valeri family, Family Marcgraviaceae Shingle Plant family, Fam anaceae Valerian family; Order Gentianales, Family Apo ily Ochnaceae Ochna family, Family Theaceae Tea fam cynaceae—Dogbane family, Family Asclepiadaceae—Milk ily; Order Violales, Family Begoniaceae Begonia family, weed family, Family Gentianaceae—Gentian family, Family Family Bixaceae Lipstick-tree family, Family Cari Loganiaceae Logania family: Order Lamiales, Family Bor caceae Papaya family, Family Cistaceae Rock-rose fam aginaceae—Borage family, Family Lamiaceae—Mint fam ily, Family Cucurbitaceae Cucumber family, Family Datis ily, Family Lennoaceae—Lennoa family, Family Verben caceae—Datisca family, Family Flacourtiaceae—Flacourtia aceae Verbena family; Order Plantaginales, Family family, Family Frankeniaceae—Frankenia family, Family Plantaginaceae Plantain family; Order Rubiales, Family Loasaceae—Loasa family, Family Passifloraceae-Passion Rubiaceae Madder family; Order Scrophulariales, Family flower family, Family Tamaricaceae Tamarix family, Fam Acanthaceae—Acanthus family, Family Bignoniaceae— ily Turneraceae Turnera family, Family Violaceae Violet Trumpet-creeper family, Family Buddlejaceae Butterfly family; Subclass Hamamelidae, Order Casuarinales, Family bush family, Family Gesneriaceae Gesneriad family, Fam Casuarinaceae-She-oak family; Order Fagales, Family ily Lentibulariaceae Bladderwort family, Family Betulaceae—Birch family, Family Fagaceae Beech family; Myoporaceae Myoporum family, Family Oleaceae Olive Order Hamamelidales, Family Cercidiphyllaceae Katsura family, Family Orobanchaceae Broom-rape family, Family tree family, Family Hamamelidaceae Witch-hazel family, Pedaliaceae Sesame family, Family Scrophulariaceae— Family Platanaceae Plane-tree family; Order Juglandales, Figwort family; Order Solanales, Family Convolvulaceae— Family Juglandaceae Walnut family; Order Leitneriales, Morning-glory family, Family Cuscutaceae—Dodder family, Family Leitneriaceae Corkwood family; Order Myricales, Family Fouquieriaceae Ocotillo family, Family Hydro Family Myricaceae Bayberry family; Order Urticales, phyllaceae Waterleaf family, Family Menyanthaceae— Family Cannabaceae Hemp family, Family Cecropi Buckbean family, Family Polemoniaceae Phlox family, aceae Cecropia family, Family Moraceae—Mulberry fam Family Solanaceae Potato family; Subclass Caryophyl ily, Family Ulmaceae Elm family, Family Urticaceae— lidae, Order Caryophyllales, Family Achatocarpaceae— Nettle family; Subclass Magnoliidae, Order Aristolochiales, Achatocarpus family, Family Aizoaceae—Fig-marigold fam Family Aristolochiaceae Birthwort family; Order Illiciales, ily, Family Amaranthaceae—Amaranth family, Family Family Illiciaceae Star-anise family, Family Schisan Basellaceae—Basella family, Family Cactaceae—Cactus draceae Schisandra family; Order Laurales, Family Caly family, Family Caryophyllaceae Pink family, Family Che canthaceae Strawberry-shrub family, Family Hernandi nopodiaceae-Goosefoot family, Family Molluginaceae— aceae-Hemandia family, Family Lauraceae-Laurel Carpet-weed family, Family Nyctaginaceae Four o'clock family, Family Monimiaceae Monimia family; Order Mag family, Family Phytolaccaceae Pokeweed family, Family noliales, Family Annonaceae—Custard-apple family, Family Portulacaceae—Purslane family; Order Plumbaginales, Canellaceae Canella family, Family Magnoliaceae—Mag Family Plumbaginaceae Leadwort family; Order Polygon nolia family, Family Myristicaceae Nutmeg family, Family ales, Family Polygonaceae Buckwheat family: Subclass Sonneratiaceae-Sonneratia family, Family Winteraceae— Dilleniidae, Order Batales, Family Bataceae Saltwort fam Wintera family; Order Nymphaeales, Family Cabom ily; Order Capparales, Family Brassicaceae—Mustard fam baceae Water-shield family, Family Ceratophyllaceae— ily, Family Capparaceae—Caper family, Family Morin Hornwort family, Family Nelumbonaceae Lotus-lily gaceae-Horse-radish tree family, Family Resedaceae— family, Family Nymphaeaceae Water-lily family; Order Mignonette family; Order Diapensiales, Family Papaverales, Family Fumariaceae Fumitory family, Family Diapensiaceae Diapensia family; Order Dilleniales, Family Papaveraceae Poppy family; Order Piperales, Family Chlo US 2009/0263516 A1 Oct. 22, 2009 ranthaceae Chloranthus family, Family Piperaceae Pep 0068. In one embodiment, potential plants comprise: per family, Family Saururaceae Lizard's-tail family; Order Abelmoschus esculentus, Abies balsamea, Abies lasiocarpa, Ranunculales, Family Berberidaceae Barberry family, Achillea millefolium, Achillea tomentosa, Aconitum napel Family Lardizabalaceae Lardizabala family, Family lus, Aconitum spp., Acorus calamus, Actaea racemosa, Menispermaceae—Moonseed family, Family Ranuncu Actinidia arguta, Actinidia chinensis, Adiantum pedatum, laceae Buttercup family, Family Sabiaceae Sabia family; Adiantum tenerum, Aesculus hippocastianum, Aframomum Subclass Rosidae, Order Apiales, Family Apiaceae Carrot melegueta, Agaricus bisporus, Agastache foeniculum, family, Family Araliaceae-Ginseng family; Order Celas Ageratum convzoides, Agrimonia eupatoria, Agropyron Cris trales, Family Aquifoliaceae Holly family, Family Celas tatum, Agropyron repens, Agrostis alba, Agrostis stolonifera, traceae—Bittersweet family, Family Corynocarpaceae— Alcea rosea, Alchemilla mollis, Alkanna tinctoria, Allium Karaka family, Family Hippocrateaceae-Hippocratea ampeloprasum, Allium cepa, Allium fistulosum, Allium family, Family Icacinaceae—Icacina family, Family Stack grande, Allium porrum, Allium sativum, Allium Schoenopra housiaceae Stackhousia family; Order Cornales, Family sum, Allium tuberosum, Allium victorialis, Aloe vera, Cornaceae—Dogwood family, Family Garryaceae—Silk Alpinia officinarum, Althaea officinalis, Amaranthus cauda Tassel family, Family Nyssaceae Sour Gum family; Order tus, Amaranthus retroflexus, Amaranthus tricolor, Ambrosia Euphorbiales, Family Buxaceae Boxwood family, Family artemisiifolia, Amelanchier alnifolia, Amelanchier Canaden Euphorbiaceae—Spurge family, Family Simmondsiaceae— sis, Amelanchier sanguinea, Amelanchier sanguineaxA. lae Jojoba family; Order Fabales, Family Fabaceae Pea family; vis, Amsonia tabernaemontana, Ananas comosus, Anaphalis Order Geraniales, Family Balsaminaceae Touch-me-not margaritacea, Anethum graveolens, Angelica archangelica, family, Family Geraniaceae-Geranium family, Family Lim Angelica dahurica, Angelica sinensis, Anthemis tinctoria, nanthaceae—Meadow-Foam family, Family Oxalidaceae— Anthoxanthum odoratum, Anthriscus cerefolium, Anthurium Wood-Sorrel family, Family Tropaeolaceae Nasturtium guildingii; Apium graveolens, Apocynum cannabinum, Ara family; Order Haloragales, Family Gunneraceae-Gunnera chis hypogaea, Aralia cordata, Aralia nudicaulis, Arctium family, Family Haloragaceae Water Milfoil family; Order lappa, Arctium minus, Arctostaphylos uva-ursi, Armoracia Linales Family Erythroxylaceae Coca family, Family rusticana, Aronia melanocarpa, Aroniaxprunifolia, Arrhen Linaceae Flax family; Order Myrtales, Family Combreta atherum elatius, Artemisia abrotanum, Artemisia absin ceae—Indian Almond family, Family Lythraceae—Loos thium, Artemisia dracunculus, Artemisia ludoviciana, Arte estrife family, Family Melastomataceae Melastome family, misia vulgaris, Asarum europaeum, Asclepias incamata, Family Myrtaceae Myrtle family, Family Onagraceae— Asclepias tuberosa, Asparagus officinalis, Aster spp.; Evening Primrose family, Family Punicaceae-Pomegranate Astilbexarendsii, Astilboides tabularis, Athyrium asperum, family, Family Thymelaeaceae Mezereum family, Family Atriplex hortensis, Atropa belladonna, Avena sativa, Aver Trapaceae Water Chestnut family; Order Podostemales, rhoa carambola, Baptisia tinctoria, Beckmannia erucifor Family Podostemaceae River-weed family; Order Polyga mis, Begonia convolvulacea, Begonia emini, Begonia gla lales, Family Krameriaceae Krameria family, Family Mal bra, Begonia manni Begonia polygonoides, Bellisperennis, pighiaceae—Barbados Chemy family, Family Polygal Berberis vulgaris, Beta vulgaris, Betula alleghaniensis, aceae Milkwort family; Order Proteales, Family Betula glandulosa, Boesenbergia rotunda, Boletus edulis, Proteaceae Protea family; Order Rafflesiales, Family Borago officinalis, Brassica cepticepa, Brassica iuncea, Rafflesiaceae Rafflesia family; Order Rhamnales, Family Brassica napus, Brassica nigra, Brassica oleracea, Brassica Elaeagnaceae—Oleaster family, Family Rhamnaceae— rapa, Bromus inermis, Buddleja davidii; Bupleurum falca Buckthorn family, Family Vitaceae Grape family; Order tum. Butomus umbellatus, Caladium spp., Calamagrostis Rhizophorales, Family Rhizophoraceae Red Mangrove arundiflora, Calamintha nepeta, Calendula officinalis, family; Order Rosales, Family Brunelliaceae—Brunellia Camellia sinensis, Campanula rapunculus, Canna indica, family, Family Chrysobalanaceae-Cocoa-plum family, Cantharellus cibarius, Capsella bursa-pastoris, Capsicum Family Connaraceae-Cannarus family, Family Crassu annuum, Capsicum frutescens, Carex morrowii. Carica laceae Stonecrop family, Family Crossosomataceae— papaya, Carthamus tinctorius, Carum carvi, Carya cordi Crossosoma family, Family Cunoniaceae Cunonia family, formis, Castanea spp., Centaurea solstitialis, Cerastium Family Grossulariaceae Currant family, Family tomentosum, Chaerophyllum bulbosum, Chamaemelum Hydrangeaceae-Hydrangea family, Family Pittospora nobile, Chelidonium majus, Chenopodium album, Chenopo ceae—Pittosporum family Family Rosaceae—Rose family, dium bonus-henricus, Chenopodium quinoa, Chrysanthe Family Saxifragaceae-Saxifrage family, Family Surian mum coronarium, Cicer arietinum, Cichorium endivia aceae Suriana family; Order Santalales, Family Balano Subsp. endivia, Cichorium intybus, Cinnamomum verum, phoraceae—Balanophora family, Family Eremolepi Cirsium arvense, Cissus discolor, Citrullus colocynthis, Cit daceae—Catkin-mistletoe family, Family Loranthaceae— rullus lanatus, Citrus limettoides, Citrus limon, Citrus Showy Mistletoe family, Family Olacaceae Olax family, reticulata, Citrus Sinensis, Citrusxparadisi; Clematis Family Santalaceae Sandalwood family, Family Vis armandii; Clematis chiisanensis, Coccoloba Caracasana, caceae Christmas Mistletoe family; Order Sapindales, Cocos nucifera, Coix lacryma jobi, Colocasia spp., Conva Family Aceraceae—Maple family, Family Anacardiaceae— laria majalis, Conyza Canadensis, Corchorus Olitorius, Sumac family, Family Burseraceae—Frankincense family, Coriandrum sativum, Cornus Canadensis, Cornus mas; Cos Family Hippocastanaceae-Horse-chestnut family, Family mos Sulphureus, Cotinus Coggy'gria, Crataegus Sanguinea, Meliaceae—Mahogany family, Family Rutaceae—Rue fam Crataegus spp., Crataegus submolis, Crithmum maritimum, ily, Family Sapindaceae Soapberry family, Family Sima Cryptotaenia Canadensis, Cucumis anguria, Cucumis melo, roubaceae-Quassia family, Family Staphyleaceae—Blad Cucumis metuliferus, Cucumis sativus, Cucurbita maxima, dernut family, Family Zygophyllaceae—Creosote-bush Cucurbita moschata, Cucurbita pepo, Cullen Corylifolium, family. Cuminum cyminum, Curcuma longa, Curcuna Zedoaria, US 2009/0263516 A1 Oct. 22, 2009

Cyclonia Oblonga, Cymbopogon citratus, Cymbopogon mar ulea, Passiflora spp.; Pastinaca sativa, Pennisetum alopecu tinii, Cynara cardunculus Subsp. cardunculus, Cyperus escu roides, Perilla frutescens, Persea americana, Petasites lentus, Dactylis glomerata, Datisca cannabina, Datura japonicus, Petroselinum crispum, Peucedanum cervaria, metel Datura Stramonium, Daucus carota, Digitalis pur Peucedanum Oreaselinum, Pfafia paniculata, Phacelia tan purea, Dimocarpus longan, Dioscorea batatas, Diospyros acetifolia, Phalaris arundinacea, Phalaris canariensis, kaki, Dipsacus sativus, Dirca palustris, Dolichos lablab, Phaseolus acutifolius, Phaseolus coccineus, Phaseolus vul Dryopteris filix-mas, Echinacea purpurea, Echinochloa fru garis, Philadelphus coronarius, Phleum pratense, Phlox mentacea, Eleusine coracana, Equisetum hyemale, Erigeron paniculata, Phoenix dactylifera, Physalis grisea, Physalis speciosus, Eriobotrya japonica, Eruca vesicaria, Erysimum philadelphica, Physalis spp., Physostegia virginiana, Phyto perofskianum, Eschscholzia Californica, Fagopyrum escu lacca americana, Pimpinella anisum, Pisum sativum, Plan lentum, Fagopyrum tataricum, Festuca rubra, Filipendula tago Coronopus, Plantago major, Plectranthus fruticosus, rubra, Filipendula ulmaria, Filipendula vulgaris, Foenicu Plectranthus spp., Pleurotus spp., Plumbago Zeylanica, Poa lum vulgare. Forsythiaxintermedia. Fortunella spp., compressa, Poa pratensis, Podophyllum peltatum, Polygo Fragariaxananassa, Frangula alnus, Fucus vesiculosus, natum odoratum, Polygonum aviculare, Polygonum chin Fumaria officinalis, Galinsoga quadriradiata, Galium Odo ense, Polygonum pensylvanicum, Polygonum persicaria, ratum, Gaultheria hispidula, Gaultheria procumbens, Geni Pongamia pinnata, Pontederia cordata, Populus incrassata, sta multibracteata, Gentiana lutea, Gentiana macrophylla, Populus tremula, Populusxpetrowskyana, Portulaca olera Geum rivale, Ginkgo biloba, Glechoma hederacea, Glyceria cea, Potentilla anserina, Poterium sanguisorba, Primula maxima, Glycine max, Glycyrrhiza glabra, Gossypium her veris, Prunella vulgaris, Prunus armeniaca, Prunus cera baceum, Guizotia abyssinica, Hamamelis virginiana, sus, Prunus persica, Prunus spp., Prunus tomentosa, Hedeoma pullegioides, Hedychium spp.; Helianthus annuus, Psathyrostachys juncea, Psidium guajava, Psidium spp.; Helianthus strumosus, Helianthus tuberosus, Helichrysum Pteridium aquilinum, Pulmonaria officinalis, Pulmonaria angustifolium, Helichrysum thianschanicum, Heliotropium saccharata, Punica granatum, Pyrus communis, Pyrus pyri arborescens, Helleborus niger, Herba schizonepetae, Hibis folia, Raphanus raphanistrum, Raphanus sativus, Rehman cus cannabinus, Hordeum hexastichon, Hordeum vulgare, nia glutinosa, Reseda luteola, Reseda Odorata, Rheum offi Hordeum vulgare subsp. vulgare, Houttuynia cordata, cinale, Rheum palmatum, Rheumxhybridum, Rhus Humulus lupulus, Hydrastis Canadensis, Hylotelephium aromatica, Rhus trilobata, Ribes grossularia, Ribes nigrum, spp., Hymenoxys hoopesi, Hyoscyamus niger, Hypericum Ribes rubrum, Ribes Sylvestre, Ribes uva-crispa, Ribesxmi henryi, Hypericum perforatum, Hypericum spp.; Hypomyces digrolaria, Ricinus communis, Rosa rugosa, Rosmarinus lactifluorum, Hyssopus officinalis, Iberis amara, Iberis semi officinalis, Rubus allegheniensis, Rubus Canadensis, Rubus pervirens, Inula helenium, Ipomoea batatas, Iris versicolor, idaeus, Rubus Occidentalis, Rubus thibetanus, Rumex Isatistinctoria, Jeffersonia diphylla, Juglans nigra, Junipe acetosa, Rumex acetosella, Rumex Crispus, Rumexpatientia, rus communis, Kochia scoparia, Koeleria glauca, Kolkwitzia Rumex scutatus, Ruta graveolens, Saccharum officinarum, amabilis, Krameria lappacea, Lactuca sativa, Lactuca ser Salix purpurea, Salvia elegans, Salvia officinalis, Salvia riola, Laportea Canadensis, Laserpitium latifolium, Sclarea, Salvia Sylvestris, Sambucus Canadensis, Sambucus Lathyrus sativus, Lathyrus Sylvestris, Laurus nobilis, Lavan ebulus, Sambucus migra, Sanguisorba minor, Sanguisorba dula angustifolia, Lavandula latifolia, Ledum groenlandi officinalis, Santolina chamaecyparissus, Saponaria officina cum, Lens culinaris Subsp. culinaris, Lentinus edodes, lis, Satureja hortensis, Satureja montana, Satureja repan Leonurus cardiaca, Lepidium sativum, Leucanthemum vul dra, Scolymus hispanicus, Scorzonera hispanica, Scrophu gare, Levisticum officinale, Ligularia dentata, Ligustrum laria nodosa, Scutellaria lateriflora, Secale cereale, vulgare, Linaria vulgaris, Lindera benzoin, Linum usitatis Sechium edule, Senecio vulgaris, Serenoa repens, Serratula Simum, Litchi chinensis, Lolium multiflorum, Lolium tinctoria, Sesamum indicum, Setaria italica, Sidalcea spp., perenne, Lonicera ramosissima, Lonicera syringantha, Silene vulgaris, Silybum marianum, Sinapis alba Subsp. Lotus comiculatus, Lotus tetragonolobus, Lunaria annua, alba, Sium sisarum, Solanum dulcamara, Solanum melon Lupinus polyphyllus, Luzula sylvatica, Lychnis chalce gena, Solanum scabrum, Solanum tuberosum, Solidago donica, Lycopersicon esculentum, Lycopersicon pimpinelli Canadensis, Solidago spp.; Solidago virgaurea, Solidagox folium, Lysimachia clethroides, Lythrum salicaria, Madia hybrida, Sonchus oleraceus, Sorghum bicolor, Sorghumx sativa, Magnolia stellata, Malus hupehensis, Malus pruni drummondii; Spinacia oleracea, Stachys affinis, Stachys byz folia, Malus spp., Malva moschata, Malva Sylvestris, antina, Stachys macrantha, Stellaria graminea, Stellaria Mangifera indica, Manihot esculenta, Marrubium vulgare, media, Stipa capillata, Symphytum officinale, Tamarindus Matricaria recutita, Matricaria spp.; Medicago sativa, indica, Tanacetum balsamita, Tanacetum balsamita Subsp. Melaleuca alternifolia, Melilotus albus, Melilotus officina balsamita, Tanacetum cinerariifolium, Tanacetum parthe lis, Melissa officinalis, Mentha arvensis, Mentha pullegium, nium, Tanacetum vulgare, Taraxacum officinale, Tetradenia Mentha spicata, Mentha suaveolens, Menthaxpiperita, riparia, Teucrium chamaedrys, Thalictrum aquilegiifolium, Menyanthes trifoliata, Microlepia platyphylla, Miscanthus Thlaspi arvense, Thuja Occidentalis, Thymus fragantissimus, saccharifiorus, Miscanthus sinensis, Momordica charantia, Thymus herba-barona, Thymus praecox. Subsp. arcticus, Monarda didyma, Monarda fistulosa, Monarda spp., Musax Thymus pseudolanuginosus, Thymus serpyllum, Thymus vul paradisiaca, Myrica pensylvanica, Nasturtium officinale, garis, ThymusXcitriiodorus, Tiarella cordifolia, Tiarella spp.; Nepeta Cataria, Nicotiana rustica, Nicotiana tabacum, Tragopogon porrifolius, Tragopogon spp.; Trichosanthes kir Nigella sativa, Ocimum Basilicum, Oenothera biennis, Ono ilowii; Trifolium hybridum, Trifolium incarnatum, Trifolium brychis viciifolia, Ophiopogon japonicus, Opuntia spp.; pannonicum, Trifolium pratense, Trifolium repens, Trigo Origanum majorana, Origanum vulgare, Oryza sativa, Oxa nella foenum-graecum, Triticum aestivum, Triticum aesti lis deppei. Oxyria digyna, Paeonia rubra, Paeonia spp.; vum Subsp. spelta, Triticum turgidium, TrolliusXcultorum, Panax quinquefolius, Panicum miliaceum, Passiflora caer Tropaeolum majus, Tsuga Canadensis, Tsuga diversifolia, US 2009/0263516 A1 Oct. 22, 2009

Tsuga mertensiana, Tussilago farfara, Tipha latifolia, sica iuncea, Brassica napa, Bromelia balansae, Brugmansi Ulmus americana, Urtica dioica, Uvularia perfoliata, Vac graveolens (ralf), Brugmansia suaveolens, Brugmansia Sua cinium angustifolium, Vaccinium corymbosum, Vaccinium veolens (old), Brugmansia suaveolens (young), Buxus micro macrocarpon, Valeriana officinalis, Valerianella locusta, philla japonica,' Buxus microphylla japonica, Cachris Veratrum viride, Verbascum thapsus, Verbena officinalis, alpina, Cactus officinalis, Calathea zebrina, Calicatus flori Veronica officinalis, Viburnum opulus, Vicia faba, Vicia dus, Campanula carpatica, Capparis spinosa inemis, Carica sativa, Vicia villosa, Vigna angularis, Vigna mungo, Vigna papaya, Carlina acaulis, Carpinifolia, Carum capsicum, unguiculata, Vinca minor, Vitis spp.; Weigela coraeensis, Caryota ureus, Casia hebecarpa, Castanea sativa, Celosia Weigela hortensis. Withania somnifera x Triticosecale spp.; cristata, Celtis Occidentalis, Celtis Occidentalis, Centauria Xanthium Sibiricum, Xanthium strumarium, Yucca filamen maculata, Cerasus japonica, Cerasus maghabab, Cera tosa, Zea mays, Zingiber officinale, Achillea ptarmica, Ajuga torania mexicana, Chaernomelis superba, Chamaechrista reptans, Aster spp., Astilbe chinensis, Bergeniaxschmidtii, fasciculata, Charnaeciparis pisifera, Chelidonium majus, Brassica chinensis, Butomus umbellatus, Buxus micro Cistus incanus, Citinis coggriaria, Clematis rectae, Clero phylla, Carpinus Caroliniana, Centaurea dealbata, dendrum speciossicum, Cobiaeum varillartum, Cocculus lau Chaenomelesxsuperba, Clematis alpina, Coreopsis verticil rifolius, Comus mass, Convalaria majalis, Coronola varia, lata, Cornus alba, Cornus sericea, Corylus maxima, Corylus a velana, Corylus a velana, Cotoneaster fangianus, Crambe cordifolia, Cyperus alternifolius, Dahlia spp.; Cotoneaster horisontalis, Cotynus Cog'gria, Cramble cardi Euphorbia amygdaloides, Fuchsia spp., Fuchsia magel folia, Crataegus praegophyrum, Crategus macrophyllum, lanica, Galium aparine, Geranium sanguineum, Geranium Crytomium fortunei, Cupress lusitanica, Cupressus semper phaeum, Geranium pratense, Geranium sanguineum, Gera virens, Cupressus sempervirens, Cycas cirinalis, Cyclonia niumxcantabrigiense, Glaux Maritima, Hamamelis mollis, oblonga, Cynnamomum zeylonicum, Darura stramonium, Hedychium coronarium, Helenium spp., Herba Schizonepe Deutria scabra, Diefenbachia leopoldii, Diefenbachia seg tae, Hosta Sieboldiana, Hydrangea quercifolia, Ipomoea iunae, Digitalis lutea, Diopiros kaka, Dracaena fragrams, aquatica, Lamiastrum galeobdolon, Magnoliaxloebneri; Dracaena sp., Dryopteris filis-max, Echinops sphae, Elea Malva verticillata, Matteuccia pensylvanica, Microbiata gnus angustifolia, Eleagnus Cemutata, Encephalaris horri decussata, Montia perfoliata, Ocimum tenuiflorum, dum, Epilobium augustifolium, Equisetum variegatum, Erio Oenothera fruticosa Subsp. fruticosa, Onoclea sensibilis, botria japonica, Erungium campestre, Erythrinia cafra, paeonia suffruticosa, Penstemon digitalis, Petasites japoni Erythrinia Crista, Erythrinia glabeliferus, Eucaliptus rudis, cus, Physalis alkekengi; Pinus Cembra, Pinus mugo, Poten Eucomia ulurifolia, EuOnimus elata, Euonomus europea, tilla fruticosa, Rhododendron spp., ribes americanum, Euonomus verrucosa, Fagopyrum suffruticosum, Fagus sil Rodgersia spp., Rodgersia podophylla, Rubus arcticus, Vatica, Fautenousus qualiqualia, Feucrium hamedris, Ficus Rubus phoenicolasius, Rubus pubescens, Rudbeckia benjamina, Ficus benjamini, Ficus elastica, Ficus purnila, maxima, Sempervivum tectorum, Soleirolia Soleirolii; Sol Ficus religiosa, Ficus sp., Ficus triangularis, Filipendula idago Caesia, Staphylea trifolia, Stephanandra incisa; Stew ulmaria, Filipendula vulgrais, Foenix Zeulonica, Forsithsia artia pseudocamelia, Strelitzia reginae, Symphoricarpos suspensa, Forsitsia europea, Fraxinus exelsior; Gallium spo orbiculatus, Symphoricarpos albus, TaxusXmedia, Vermonia rium, Gardenia jasminoides, Gaultheria procumbens, Genti gigantea, Veronica austriaca ssp teucrium, Veronica bec ana cruciata, Gentiana littorala, Gentiana macrophilla, cabunga and Viburnum plicatum. Gentiana tibetica, Geranium maculata, Geum fanieri, Geum 0069. In another embodiment, potential plants comprise: macrophyllum, Gingko biloba, Gnetum guemon, Gratiola Abies cephalonica, Abies firma, Acer campestre, Acer mand officinalis, Gravilea robusta, Gravilea robusta, Gravilia Shurica, Acer palmaturn "burgundy. Acer tataricum, Acer robusta, Haser trilobum, Helianthus annus, Heraclelum truncatum, Acolypha hispida, Aconitum napellus, Actinidi pubescens, Hernerocalis spp., Hhaemanthus katharina, colonicta, Actinidia chinensis, Actinidia colonicta, Adamso Hissopus zeraucharicus, Hiuga reptans, Hosta fortuna, nia digitata, Adianthum radiatum, Adianthum trapeziefor Hosta fortunaea, Hosta lancefolia, Hosta zibalda, Hydroco mis, Aechmea luddemoniana, Aesculus hippocastianum, Aes tile asiatica, Hydrocotile asiatica, Hyppoach rhamnoides, culus hypocastianum, Aesculus waertilensis, Aesculus Ilex agnifolium, Ilex cornuta, Inula hilenium, Ipomea tricolor, woerlitzenis, Aessopteria crasifolia, Agastache mexuicana, Iris alida, Iris pseudocarpus, Jacobinia sp., Jasminum fruto Agatis robusta, Ageratum conizoides, Aglaonema commuta carus, Juca sp., Juglands regia, Juniperus "blue pacific. tus, Agrimonia eupatora, Ailantus altissima, Alchemilla sp., Keyleiteria paniculata, Kolkwitzia amabilis, Korria Alium Cernum (wild), Allium fistulosum, Allium nutans, japonica, Lal lab purpurea, Lapia dulcis, Larix dedidua, Allium sp., Alum japonica, Amelanchier spicata, Amigaalus Laurus nobilis, Laurus nobilis, Lavandula officinalis, Lavan nana, Ananas Comosus, Anemonajaponica, Antericum ramo dula officinalis, Leontopodium alpinum, Liatris spinata, sum, Anthurium altersianum, Anthurium andreanum, Anthu Liclun barbatum, Ligustum vulgare, Linium hirsutum, Lippa rium elegans, Anthurium hookeri, Anthurium magnificurn, dulcis, Livistona fragrams, Lobelia siphitica, Luglands nigra, Anthyrium filis-femina, Anthyrium nopponicum, Aralis Lupinus luteaus, Lycodium japonicum, Magnolia cobus, mandshurica, Archirantus bidentata, Armoracea rusticana, Magnolia loebheril, Magnolia agrifolia, Matteucia strutiop Armoraica ristica, Artemisia dracunculus, Asimina triloba, toris, Mespilus germanica, Metasequoia glyptotrobioldes, Asorum canadensis, Asplenium australasicum, Aster-Nova Metrosideros excelsa, Microlepia platphylla, Microsorium anglicae, Astragulus sinicus, Atropa Belladonna, Austola punctatum, Minispermum dauricum, Mirica certifera, Mon chia australis, Bactisia australis, Barbaric sp., Berberis stera deliciosa, Monstera pertusa, Morus alba, Murraya thungergi, Berberis vulgaris, Bergenia crassifolia, Betula exotica, Musa textilis (Leaf), Musa textilis (Stem), Myrthus alba, Betula daurica, Betula nigra, Betula nigra (flower), communis, Myrthus comunis, Nepeta cataria, Nicodemia Betula nigra (leaf), Betula pendula, Betula pendula, Bocco diversifolia, Nicotiana tabacum, Olea europaea, Olea nia cordata, Boechimeria boloba, Boxus sempervirens, Bras olcaster, Oreopanax capitata, Origanurn vulgare, Osman US 2009/0263516 A1 Oct. 22, 2009

thus spp., Osmunda regalis, Osmundastrum claytonionum, located between 35° north latitude and 35° south latitude. In Ostrea carpinifolia, Ostrea connote, Oxobachus nictogenea, accordance with another embodiment of the present inven Pachyra affinis, Paeonia daurica, Paeonia lactiflora, Paeonia tion, therefore, potential plants comprise: the agave, Aga sufructicisa, Parrotia persica, Parthenosicus tricuspidata, vaceae, family including Such members as: Yucca elata, Y. Pegamun hamalis, Pelagonium Zonale, Pelargoniurn Zonale, breviflora, Agave deserti, A. chrysantha, Dasylirion wheeleri; Pentaphylloides fruticosa, Phebodium aureum, Philoden the buckwheat, Polygonaceae, family. Such as Eriogonum dron amurense, Phylidendron speciosus, Phyllanthus gran fasciculatum; the crowfoot, Ranunculaceae, family, such as difolium, Phyllitis scolopendrium, Phymatosorus scolopen Delphinium Scaposum, Anemone tuberosa and D. parishii: dria, Physalis Creticola, Picea Schrenkiana, Pieras japonica, the poppy, Papaveraceae, family, including Platystemon Cali Pigelia pennata, Pinus bungiana, Pinus pinea, Pinus pumila, fornicus, Argemone pleiacantha, Corydalis aurea, Pinus salinifolia, Pinus silvestris, Pinus sirtrobus, Pinus stro Eschschoizia Californica and Ar: corymbosa: members of the bus, Piper chaba, Piper nigrum, Pithecelobium unguis, Pit mustard, Cruciferae, family, such as Dithyrea Californica, tisporum tibica, Plantago major; Plantago minor; Platanus Streptanthus carinatus and Lesquerella gordoni; members of acidentalis, Platicada grandiflora, Podocarpus spinulosus, the legume, Leguminosae, family, such as Acacia greggii, Podophyllum amodii, Poligonum aviculare, Poligomun lati Prosopis velutina, A. Constrica, Senna covesii, Cercidium folia, Polygonium odoratum, Polygonum cuspidatum, Poly floridum, C. microphyllum, Lotus huminstratus, Krameria monium ceruleum, Polyschium braunii, Portulaca oleacea, parvifolia, Parkinsonia aculeata, Calliendia eriophylla, Portulaca oleracea, Potentilla alba, Poterium sangiusorba, Lupinus arizonicus, Olivineya tesota, Astragalus lentiginosus, Princepia sp., Prunella vulgaris, Prunus cerasifera, Prunus Psorothamunus spinosus and Lupinus sparsiflorus; members serotica, Prunus xocane, Pseudotsuga menzisia, Psidium of the loasa family, Loasaceae, including Mentzelia involu guajava, Psychotria metbacteriodomasica, Psychotria crata, M. pumila and Mohavea Confertiflora; members of the nigropunctata, Pterigota alata, Puansetia sp., Pulmonaria cactus, Cactaceae, family, such as Carnegiea gigantia, Opun molissima, Quercus castanufolia, Quercus imbricaria, Ouer tia leptocaulis, Ferocactus wislizenii, O. bigelovii, O. cus migra, Quercus robur fastigiata,' Quercus rubra, Ouer pheacantha, O. versicolor; O filgida, Echinocereus engel cus trojana, Ratibiunda columnus-Fera, Rauwolfia tetra mannii, Mammillaria microcarpa, O. basilaris, Stenocereins phylla, Reseda luteola, Rhododendron spp., Rhus thurberi, O. violacea, M. tetrancistra, O. ramosissima, O. toxicodenta, Rimula japonica, Rosa cocanica, Rosa multi acanthocarpa, E. pectinatins and O. arbuscula; members of flora, Ruschia indurata, Ruta graveolens, Salis babilonics, the evening primrose, Onagraceae, family, such as Oenothera Salix tamarisifolia, Sambucus niora, Sanchezia nobilis, deltoides, Camissonia claviformis and Oe. primiveris; mem Schisandra chinensis, Scotch pine, Scutellaria certicola, bers of the milkweed, Asclepiadaceae, family, including Ascl Scutellarian altissima, Sedum album, Sedum telchium, Sene epias erosa, A. sublata and Sarcostemma Cynanchoides; cio platifila, Senseviera sp., Sering a josiceae, Seruginea members of the borage, Boraginaceae, family, Such as Cryp suffruticisa, Sesbania exaltata, Sesbania speciosa, Sibirea tantha augustifolia and Amsinckia intermedia; members of altaiensis, Siring a vulgaris, Slufera sp., Sorbocotoneaster the Sunflower, Compositae, family, including Baccharis Saro sp., Sorbus aucuparia, Sorbus cominicta, Spartina potenti throides, Monoptilon belloides, Erieron divergens, Zinnia flora, Spathiphyllum cochlearispatum, Spathiphyllum gran acerosa, Melampodium leucanthan, Chaenactis fremontii, diflorum, Stachis lanata, Stepochlaena tenuifolia, Sterulia Calycoseris wrightii, Malacothrix Californica, Helianthus elata, Stevartia coreana, Strelitzia reglinae, Sulda sanganea, annus, H. niveus, Geraea canescens, Hymenothrix wislizenii, Sundapsis spp., Symphitium officinalis, Syngonium aurutum, Encelia farinosa, Psilostrophe cooperi, Baileya multiradiata, Syngoniurn podophyllum, Taccus bacata, Tagetes minuta, Bebbia iuncea, Senecio douglasii, Trixis Californica, Talictrum minus, Talictrum sp., Tamarindus india, Machaeranthera tephrodes, Xylorhiza tortifolia, Cirsium Tapeinochilos spectabilis, Taraxacum officinalis, Taxodium neomexicanum, Antennaria parviflora and Ch. douglasii; dixticum, Taxodium dixticum (Acetic acid), Taxodium dixti members of the caltrop, Zygophyllaceae, family, including cum (H2O). Taxus cuspidata, Taxus hiksii, Taxus media, Tet Larrea tridentata and Kallstroemia grandiflora; members of raclinis articulata himensis, Thalictum flavum, Thuja Occi the mallow, Malvaceae, family, including Hibiscus coulteri, dentalis, Thuja Occidentalis, Thymus Camosus, Thymus H. denudatus and Sphaeralcea ambigua; members of the carnosus, Thymus Cretaceus, Thymus cytridorus "aureus,' phlox, Polemoniaceae, family, such as Luanthus aureus; Thymus lemabarona, Thymus portugalense, Thymus praecox, members of the unicorn plant, Martyniaceae, family, Such as Thymus praecox' "arcticus,” Thymus pseudolamginosus, Proboscidiea altheaefolia; members of the gourd, Cucurbi Thymus pulleglodes "lemons.” Thymus pulliglodes, Thymus taceae, family, Such as Cucurbita digitata; members of the serphylum, Thymus serphylum (wild), Thymus speciosa, Thy lily, Lilaceae, family, including Calochortus kennedy'i, Dich mus thrasicus, Thymus vulgaris, Thymus vulgaris "argen eloStemma pulchellum, Allium macropetalum and Hespero teus,' Thymus vulgaris “oregano.” Thymus wooly, Trambe callis indulata; members of the ocotillo, Fouquieriaceae, pontica, Trevesia sungaica, Trifolium pratense, Tsuga family, including Fouquieria splendens; members of the fig Canadensis "penola,” Titia Orientalis "eligantissima, Tula wort, Scrophulariaceae, family, such as Castilleja sp., Pen ocidentalis “columbia. Tulip tree, Turnera ulmifolia, Ulmus stemon parryi and Orthocarpus purpurascens; members of pumila, Uschiusa sp., Valeriana officinalis, Veratrum nigrum, the acanthus, Acanthaceae, family, including Anisacanthus Verium oleander, Viburnum opulus, Vinca minor; Vincetocsi thurberi, Justicia Californica and Ruellia nudiflora; members cum officinalis, Vitis labrissa, Xanthosoma Sagittifolium of the four o'clock, Nyctaginaceae, family, such as Allionia (leaf), Xanthosoma Sagittifolium (stem), XeupressOcyparis incarnata, Abronia villosa and Mirabilis multiflora; members deylandii, Yucca elephantipes, Zelcova and Zingiber officina of the geranium, Geraniaceae, family, including Erodium lis. cicutarium; members of the waterleaf, Hydrophyllaceae, 0070 Another group of potential plants comprise the family, Such as Nama demissium, Phacelia bombycina and Ph. plants that are indigenous to arid regions, for example, those distans; members of the bignonia, Bignoniaceae, family, Such US 2009/0263516 A1 Oct. 22, 2009

as Chilopsis linearis; members of the vervain, Verbenaceae, example, the treatment can be with water and then with one or family, including Glandularia gooddugii and Verbena a series of stressors. The extracts are then tested to determine neomexicana; members of the mint, Labiatae, family, such as whether they become an extract of the invention. Thus, it is Hyptis emoryi and Salvia columbariae; members of the possible that, of several extracts prepared from the same broomrape, Orobanchaceae, family, Such as Orobanche coo potential plant subjected to different pre-harvest treatment, peri; members of the portulaca, Portulaceae, family, such as only some may become extracts of the invention. Talinum auriantiacum; members of the carpet-weed, 0074. In one embodiment, the potential plant is subjected Aizoaceae, family. Such as Sesuvium verrucosum: members to a pre-harvest treatment comprising stressing the plant of the flax, Linaceae, family, such as Linum lewisii; members through the use of chemical elicitors, which act as stressor of the potato, Solanaceae, family, including Nicotiana trigo agent, and/or mechanical wounding, drought, heat, or cold, nophylla and Physalis lobata; and members of the cochlo which activate plant defense pathways, before tissue collec spermum, Cochlospermaceae, family, such as Amoreuxia tion and extraction. palmatifida. 0075. In another embodiment, the stressor employed 0071. In accordance with one embodiment of the present involves exposing a potential plant to a solution of one or invention, the potential plant is selected from the group com more chemical elicitors to induce defense metabolic path prising: Allium tuberosum, Althacea officinalis, Amaranthus ways and secondary metabolites prior to collection of plant candathus, Ambrosia artemisiifolia, Angelica sinensis, Aro tissues. Known chemical elicitors reported in the literature niaxprunifolia, Asarum europaeum, Begonia Hannii, Bego include oZone, hydrogen peroxide, jasmonic acid and its nia polygonoides, Brassica oleracea, Brassica napus, Bras derivatives, arachidonic acid, Salicylic acid and ester deriva sica oleracea, Bromus inermis, Chenopodium quinoa, tives, alpha- and gamma-linolenic acids, Volicitin, peptides, Citrullus lanatus, Conyza Canadensis, Cynara cardunculus oligopeptides, Saccharides, oligosaccharides such as chito Subsp. Cardunculus, Daucus carota, Dolichos lablab, Foen– san, and synthetic chemicals such as benzo-1,2,3-thiadiazole iculum vulgare, Hypomyces lactifluorum, Iberis Sempervi 7-carbathioic acid S-methyl ester (BTH). rens, Lotus corniculatus, Lunaria annua, Manihot escu 0076 A stressor may be one or more organic compound. lenta, Matricaria recutita, Melilotus albus, Phaseolus Some exemplary compounds that may be used as stressors vulgaris, Physostegia virginiana, Pisum sativum, Raphanus include jasmonic acid, jasmonic acid lower alkyl esters, Cli raphanistrum, Rheum rhabarbarum, Ribes Sylvestre, Rubus nolenic acid, C.-linolenic acid lower alkyl esters, Y-linolenic occidentalis, Rumex Crispus, Rumex scutatus, Salvia offici acid, Y-linolenic acid lower alkyl esters, arachidonic acid, nalis, Solidago Canadensis, Solidago sp.: Solidagoxhybrida, arachidonic acid lower alkyl esters, salicylic acid. Tamarindus indica, Tanacetum cinerariifolium, Taraxacum 0077. In one embodiment of the present invention, the officinale, Tropaeolum majus, Tsuga Canadensis, Tsuga stressor is Y-linolenic acid, Y-linolenic acid lower alkyl esters, diversifolia, Vaccinium angustifolium, Zea mays, Zingiber arachidonic acid, arachidonic acid lower alkyl esters, or a officinale. combination thereof. 0078. A stressor may be able to induce abiotic stresses in Pre-Harvest Treatment plants. Thus, for example, plants can be treated with one or 0072. Once a potential plant has been chosen, a pre-har more mechanical or chemical stress prior to tissue collection. vest treatment is selected, wherein the treatment can be water 0079 Mechanical stress can be performed, for example, or water in combination with one or more stressor, elicitor, or between about twelve hours to about ten days prior to tissue inducer. A pre-harvest treatment comprises contacting or collection. In one embodiment of the present invention, a treating a potential plant, or material from a potential plant, potential plant can be subjected to one or more mechanical with one or more stressor, elicitor, or inducer. Examples of stress between about one day to about three days prior to stressors, elicitors and inducers include, but are not limited to, tissue collection. In another embodiment, a potential plant chemical compounds, for example organic and inorganic can be subjected to one or more mechanical stress between acids, fatty acids, glycerides, phospholipids, glycolipids, about three to about six days prior to tissue collection. In a organic solvents, amino acids and peptides, monosaccha further embodiment, a potential plant can be subjected to one rides, oligosaccharides, polysaccharides and lipopolysaccha or more mechanical stress between about four to about eight rides, phenolics, alkaloids, terpenes and terpenoids, antibiot days prior to tissue collection. In another embodiment a ics, detergents, polyamines, peroxides, ionophores, etc.; potential plant can be subjected to one or more mechanical Subjection of the plant material to a physical treatment, Such stress between about six to about ten days prior to tissue as ultraviolet radiation, low and high temperature stress, collection. osmotic stress induced by salt or Sugars, nutritional stress 0080 Chemical stress can be induced in a potential plant defined as depriving the plant of essential nutrients (e.g. nitro by spraying plant material once, or more than once, with an gen, phosphorus or potassium), in order to induce or elicit aqueous or alcoholic Solution of one or more chemical elici increased production of one or more chemicals. The one or tor. Chemical stress can also be induced by feeding a potential more stressor (i.e. chemical compound or physical treatment) plant with an aqueous or alcoholic Solution of one or more may be applied continuously or intermittently to the plant chemical elicitor. Similarly, a potential plant can be subjected material. In one embodiment, such treatment may be accom to a chemical stress by means of contact with an airborne plished by contacting the plant material with a solution con transport of one or more chemical elicitor. Chemical stress taining the elicitor or by irradiating the plant material or can be performed, for example, between about one hour to exposing the plant material to other environmental stresses about 10 days prior to tissue collection. In one embodiment of Such as temperature stresses. the present invention, a potential plant can be subjected to one 0073. One skilled in the art would understand that a poten or more chemical stress between about ten hours and about tial plant can be subjected to a variety of pre-harvest treat one day prior to harvesting the plant tissue. In another ments and an extract prepared after each treatment. For embodiment, a potential plant can be treated with one or more US 2009/0263516 A1 Oct. 22, 2009 chemical by spray one day before harvesting. In a further I0086 Separation of the liquid and solid fractions can be embodiment, a potential plant can be subjected to one or more achieved by one or more standard processes known to those chemical stress between about one day to about three days skilled in the art. For example, the solid material can be prior to harvesting the plant tissue. In other embodiments, a separated from the solvent by centrifugation, filtration (regu potential plant can be subjected to one or more chemical lar or Suction), or other means known in the art to separate stress between about two to about four days and between Solids from a solution. In addition, when an alcoholic or about five to about ten days prior to harvesting the plant organic solvent is used, the potential pre-extract can be dried tissue. to remove the solvent and then re-suspended or dissolved in an aqueous solvent prior to testing against a panel of extra 0081 Various combinations of the above-mentioned stres cellular proteases. The alcoholic or organic solvent can be sors and treatment regimes can be employed to induce or removed by standard methods including, for example, by enhance the production of one or more extracellular proteases distillation or by the use of a lyophilizer, a speedvac, a rotary in the plant material. One skilled in the art would be able to evaporator, or a vacuum pump and then further dried under determine from the results of the assay against the panel of vacuum, if necessary in order to remove any remaining Sol extracellular proteases whether it is desirable to follow one or Vent. more than one of the stressor regimes. 0087. The dried extract can be dissolved can be dissolved in an aqueous buffer, or in a mixture of an aqueous buffer and Harvesting the Plant Material for Extraction and Optional a suitable solvent (such as dimethylsulfoxide) prior to anal Storage Treatment ysing its activity against a panel of extracellular proteases. An 0082. The plant material may be used immediately after example of an aqueous buffer is Tris-HCl buffer at a suitable pre-harvest treatment, or it may be desirable to store the plant pH, such as between pH 6 and pH 8. In one embodiment, material for a period of time prior to performing the extraction Tris-HCl buffer at pH 7 is used. procedure(s). If desired, the plant material can be treated prior I0088 Solvents A, B and C in FIG. 1 generally represent to storage, for example, by drying, freezing, lyophilising, or separate classes of solvents, for example, aqueous, alcoholic Some combination thereof. and organic. The solvents can be applied in specific order, for 0083. Following treatment to prepare the plant material for example, a polar to non-polar order or in a non-polar to polar storage, the plant material may be stored for a period of time order. Alternatively, the solvents can be applied in a random prior to being contacted with a first solvent. The storage time sequence. In all cases, however, the Solid matter should be may be of various durations, for example, the storage period dried prior to contact with the subsequent solvent. may be between a few days and a few years. In one embodi I0089. The term “liquid” is used to denote matter that is ment of the invention, the plant material is stored for a period distinct from the solid, insoluble matter. Thus, a liquid, which of less than one week. In another embodiment, the plant may be converted to a gas or function in a gaseous form (as in material is stored for a period between one week to one the case with steam, for example), can serve as a solvent. month. In a further embodiment, the plant material is stored Likewise, other non-Solid solvents may be used such as for a period of between one month to six months. In other highly viscous liquids or other gaseous solvents, some of embodiments, the plant material is stored for periods of which can then be converted into a liquid phase. A liquid between four months to one year and for a period over one Solvent may also indicate a composition or a mixture of year in duration. Solvents. Common examples include a buffered aqueous solution, such as a TRIS-HCl buffer, an ethanol/methanol The Extraction Process combination and combinations of an alcoholic solvent and a co-solvent, such as methanol or water. 0084. In accordance with the embodiment depicted in 0090 The plant material employed in the extraction pro FIG. 1, three basic extraction processes can be performed in cess can be the entire potential plant, or it can be one or more sequence to generate potential pre-extracts. In other embodi distinct tissues from a plant, for example, leaves, seeds, roots, ments of the present invention, greater of fewer extraction stems, flowers, or various combinations thereof. The plant processes are contemplated. Regardless of the number of material can be fresh, dried or frozen. If desired, the plant extraction processes, the procedure for each extraction pro material can be treated prior to the extraction process in order cess entails contacting the solid plant material with a solvent to facilitate the extraction of the inhibitory activity. Typically with adequate mixing and for a period of time Sufficient to Such treatment results in the plant material being fragmented ensure adequate exposure of the Solid plant material to the by some means such that a greater Surface area is presented to solvent such that inhibitory activity present in the plant mate the solvent. For example, the plant material can be crushed or rial can be taken up by the solvent. Typically, the extraction sliced mechanically, using a grinder or other device to frag procedures are conducted over a period of time between about ment the plant parts into Small pieces or particles, or the plant 10 minutes and about 24 hours at a temperature between material can be frozen liquid nitrogen and then crushed or about 4°C. and about 50° C. Adequate contact of the solvent fragmented into Smaller pieces. with the plant material can be encouraged by shaking the 0091. In one embodiment of the present invention, plant Suspension for 15 minutes to 24 hours at a temperature material is first fragmented and then extracted with a first between about 4° C. and about 50° C. solvent comprising an aqueous TRIS-HCl buffer at pH 6-8 for 0085. The liquid fraction is then separated from the solid a period of between 30 minutes to 8 hours at a temperature (insoluble) matter resulting in the generation of two fractions: between about 4 to about 50° C. In an alternative embodi a liquid fraction, which is a potential pre-extract, and a solid ment, aqueous buffer has a pH of about 7. In another embodi fraction. In accordance with the embodiment depicted in FIG. ment, extraction takes place over about 30 minto 2 hours. In 1, the extraction process is then repeated with a second and a a further embodiment, the extraction takes place at a tempera third solvent, to yield three potential pre-extracts. ture between about 4 to about 25°C. In another embodiment, US 2009/0263516 A1 Oct. 22, 2009

the extraction takes place at a temperature between about 4 to using a panel of proteases comprising: MMP-1, MMP-2, about 10°C. In another embodiment, the extraction is per MMP-3, MMP-9, cathepsin B, cathepsin D, cathepsin G, formed at a temperature of about 4°C. for about 30 minutes. cathepsin L, cathepsin K, human leukocyte elastase (HLE), 0092. In one embodiment of the invention, ethanol is used clostripain and subtilisin. In another embodiment, the ability as an alcoholic Solvent either alone or in combination with a of a potential pre-extract/extract to inhibit at least one extra co-solvent. In another embodiment, a combination of ethanol cellular protease is determined using a panel of proteases and methanol is used as the alcoholic solvent, wherein the comprising: MMP-1, MMP-2, MMP-3, MMP-9 and cathep range of ethanol:methanol is between about 50:50 and about sin B. 85:15. In a further embodiment, the plant material is con tacted with an alcoholic solvent for a time period between 0099. One skilled in the art would appreciate that there are about 10 minutes to one hour at a temperature between about numerous methods and techniques for measuring qualita 4 to about 25°C. In another embodiment, the plant material is tively and/or quantitatively the ability of the potential pre contacted with an alcoholic solvent for a time period between extracts and/or potential extracts to inhibit the activity of about 15 and about 30 minutes. In other embodiments, the extracellular protease(s). plant material is contacted with an alcoholic Solvent at a 0100 For example, there are currently several assays to temperature between about 4 to about 10°C. and at about 4 measure the activity of MMPs, elastase and cathepsins (for a C. review of these methods, see Murphy and Crabbe. In Barrett 0093. In one embodiment of the present invention, dieth (ed.) Methods in Enzymology. Proteolytic Enzymes. Aspartic ylether, hexane, dichloromethane, or ethylacetate extract is Acid and Metallopeptidases, New York: Academic Press, used as the organic solvent. In another embodiment, the 1995, 248: 470), including the gelatinolytic assay (which is residual solid plant material is shaken for one to twenty-four based on the degradation of radio-labelled type I collagen), hours with the organic solvent. In a further embodiment, the the Zymography assay (which is based on the presence of residual solid plant material is shaken for one to fifteen hours. negatively-stained bands following electrophoresis through In other embodiments, the residual solid plant material is Substrate-impregnated SDS polyacrylamide gels) and a shaken for one to eight hours and for one to four hours with microtitre plate assay developed by Pacmenet al., (Biochem. the organic solvent. In another embodiment, dichlo Pharm. (1996) 52:105-111). romethane is used as the organic solvent and the extraction is 0101. Other methods include those that employ auto performed at room temperature for about 2 hours. quenched fluorogenic Substrates, which do not have some of 0094. The present invention contemplates that the extrac the drawbacks associated with the above methods, such as the tion process may be carried out on various scales including use of radioisotopes, labour-intensiveness, long incubation known large, medium and Small-scale methods of preparing times and/or low sensitivity. Many fluorogenic Substrates eXtractS. have been designed for quantification of the activity of 0095 Once the potential pre-extracts have been isolated, MMPs, elastase, and cathepsins through fluorescent level they can be tested directly for their ability to inhibit extracel variation measuring (reviewed by Nagase and Fields (1996) lular protease activity, or they may be subjected to further Biopolymers 40:399-416). separation procedures to generate a potential extract as 0102 Fluorescence polarization assays are based on the described below and outlined in FIG. 2. principle that when fluorescent molecules are excited with plane polarized light, they will emit light in the same polar Determination of Extracellular Protease Inhibitory Activity ized plane provided that the molecule remains stationary in an Extract throughout the excited state. However, if the excited molecule 0096. In accordance with the present invention, the plant rotates or tumbles during the excited State, then light is emit extracts are capable of inhibiting the activity of at least one ted in a plane different from the excitation plane. If vertically extracellular protease. In the context of the present invention, polarized light is used to excite the fluorophore, the emission a plant extract that decreases the activity of an extracellular light intensity can be monitored in both the original vertical protease by at least 20% when measured according to one of plane and also the horizontal plane. The degree to which the the assays described herein is considered to be capable of emission intensity moves from the vertical to horizontal plane inhibiting the activity of that protease. is related to the mobility of the fluorescently labelled mol 0097 Extracellular proteases that may be used to test the ecule. If fluorescently labelled molecules are very large, they ability of the extract to inhibit extracellular protease activity move very little during the excited state interval, and the include, but are not limited to, matrix metalloproteases emitted light remains highly polarized with respect to the (MMPs), cathepsins, elastase, plasmin, TPA, uPA, kallikrein, excitation plane. If fluorescently labelled molecules are ADAMS family members, neprilysin, gingipain, clostripain, small, they rotate or tumble faster, and the resulting emitted thermolysin, serralysin, and other bacterial and viral pro light is depolarized relative to the excitation plane. Therefore, teases. FP can be used to follow any biochemical reaction that results 0098. It is contemplated that for some purposes, it may be in a change in molecular size of a fluorescently labelled desirable to determine the ability of the potential pre-extract/ molecule (e.g. protein-DNA interactions; immunoassays: extract to inhibit a certain set or group of extracellular pro receptor-ligand interactions; degradation reactions). teases. For example, it may be useful to determine which (Adapted from Bolger R. Checovich W. (1994) Biotech potential pre-extracts/extracts are capable of inhibiting at niques 17(3):585-9.). least one human extracellular protease. In this case a panel of 0103) Another method of measuring extracellular protease extracellular proteases may be designed that comprises those activity makes use of the fluorescent activated Substrate con proteases of particular interest. In one embodiment of the version (FASC) assay described in Canadian Patent No. present invention, the ability of a potential pre-extract/extract 2,189,486 (1996) and in St-Pierre et al., (1996) Cytometry 25: to inhibit at least one extracellular protease is determined 374-38O. US 2009/0263516 A1 Oct. 22, 2009

0104 Various formats known in the art may be employed muscle cells. HUVECs can be isolated from umbilical cords to test the ability of the potential pre-extracts and potential using standard methods (see, for example, Jaffe et al. (1973) extracts to inhibit the activity of extracellular proteases. For J. Clin. Invest. 52: 2745), or they can be obtained from the example, the potential pre-extract/extract may be tested ATCC or various commercial sources, as can other Suitable againstone or more proteases in a sequential fashion or it may endothelial cell lines. Examples of suitable neoplastic cell be tested against a plurality of proteases, such as an array of lines include those that are available from the AmericanType extracellular proteases, simultaneously. The assays may be Culture Collection (ATCC), which currently provides 950 adapted to high throughput in order to facilitate the simulta cancer cell lines, and other commercial sources. neous testing of a potential pre-extract/extract against a plu 0110. In accordance with one embodiment of the present rality of proteases. High throughput techniques are constantly invention, a potential pre-extract/extract that demonstrates being developed and the use of Such techniques to adapt the the ability to decrease cell migration by about 10% when used assays in the future is also considered to be within the scope at a concentration of about 10 mg/ml in at least one of the of the present invention. above-described assays is selected as an extract of the inven 0105. In one embodiment of the present invention, a tion. potential pre-extractor potential extract is selected for further 0111. In accordance with another embodiment, a potential testing when it demonstrates inhibitory activity against one pre-extract/extract that demonstrates the ability to decrease extracellular protease. In another embodiment, a potential cell migration by about 10% when used at a concentration of pre-extract or potential extract is selected for further testing about 2.5x in at least one of the above-described assays is when it demonstrates inhibitory activity against two or more selected as an extract of the invention, wherein 1x corre extracellular proteases. In a further embodiment, a potential sponds to the concentration of the potential pre-extract/ex pre-extract or potential extract is selected for further testing tract required to inhibit the activity of a selected extracellular when it demonstrates inhibitory activity against three or more protease by at least 50% (i.e. the ICs). extracellular proteases. In another embodiment, a potential pre-extract or potential extract is selected for further testing In Vivo Testing when it demonstrates inhibitory activity against four or more 0.112. As an alternative, or in addition, to the above-de extracellular proteases. scribed in vitro tests, the ability of the potential pre-extracts/ extracts or extracts of the invention to inhibit cell migration in Determination of the Ability of the Extract to Modulate Cel Vivo can be assessed using various standard techniques. For lular Activity example, the ability of the potential pre-extracts/extracts to 0106. In accordance with the present invention, extracts inhibit endothelial cell migration can be determined using the are selected by their ability to inhibit one or more extracellu chick chorioallantoic membrane (CAM) assay, Matrigel plug lar protease and to modulate one or more cellular activity. In assay and/or corneal micropocket assay. one embodiment, extracts are selected by their ability to slow 0113. The CAM assay can be used to evaluate the ability of down, inhibit or prevent cell migration. an extract to inhibit growth of blood vessels into various 0107 There are a number of assays known to one skilled in tissues, i.e. both angiogenesis and neovascularization (see the art, which can be used to test an extract for the ability to Brooks et al., in Methods in Molecular Biology, Vol. 129, pp. modulate cellular activity. For example, various cell migra 257-269 (2000), ed. A. R. Howlett, Humana Press Inc., tion assays can be used to test the extracts, such as those Totowa, N.J.; Ausprunket al., (1975) Am. J. Pathol. 79:597 described herein in Example IV. 618; Ossonski et al., (1980) Cancer Res., 40:2300-2309). The 0108. In general, the ability of an extract to inhibit migra CAM assay measures neovascularization of whole tissue, tion of endothelial and/or neoplastic cells can be assessed in wherein chick embryo blood vessels grow into the CAM or vitro using standard cell migration assays. Typically, Such into the tissue transplanted on the CAM, and is, therefore, a assays are conducted in multi-well plates, the wells of the well-recognised assay model for in vivo angiogenesis. In plate being separated by a Suitable membrane into top and addition, the assay provides an internal toxicity control in that bottom sections. The membrane is coated with an appropriate the chick embryo is exposed to the potential pre-extract/ compound, the selection of which is dependent on the type of extract over the course of the assay. The health of the embryo cell being assessed and can be readily determined by one can, therefore, provide an indication of the cytotoxicity of the skilled in the art. Examples include collagen or gelatine for eXtract. endothelial cells and Matrigel for neoplastic cell lines. An 0114. The Matrigel plug assay is also a standard method appropriate chemo-attractant, such as EGM-2, IL-8, aFGF, for evaluating the anti-angiogenic properties of compounds in bFGF and the like, is added to the bottom chamber as a vivo (see, for example, Passaniti, et al., (1992) Lab. Invest. chemo-attractant. An aliquot of the test cells together with the 67:519-528). In this assay, an extract is introduced into cold potential pre-extract/extract are added to the upper chamber, liquid Matrigel which, after Subcutaneous injection into a typically various dilutions of the potential pre-extract/extract Suitable animal model, Solidifies and permits penetration by are tested. After a suitable incubation time, the membrane is host cells and the formation of new blood vessels. After a rinsed, fixed and stained. The cells on the upper side of the suitable period of time, the animal is sacrificed and the Matri membrane are wiped off, and then randomly selected fields gel plug is recovered, usually together with the adjacent Sub on the bottom side are counted. cutaneous tissues. Assessment of angiogenesis in the Matri 0109 Various cell lines can be used in cell migration gel plug is achieved either by measuring haemoglobin or by assays. Examples of suitable endothelial cell lines include, scoring selected regions of histological sections for vascular but are not limited to, human umbilical vein endothelial cells density, for example by immunohistochemistry techniques (HUVECs), bovine aortic endothelial cells (BAECs), human identifying specific factors such as hemagglutinin (HA), coronary artery endothelial cells (HCAECs), bovine adrenal CD31 (platelet endothelial cell adhesion molecule-1) or Fac gland capillary endothelial cells (BCE) and vascular smooth tor VIII. Modifications of this assay have also been described US 2009/0263516 A1 Oct. 22, 2009

(see, for example, Akhtaret al., (2002) Angiogenesis 5:75-80; to the solvent being used or to the extraction procedure Kragh et al., (2003) IntJ Oncol. 22:305-11). employed in order to compensate for variations that occur 0115 The corneal micropocket assay is usually conducted during scale-up and render the overall procedure more ame in mice, rats or rabbits and has been described in detail by nable to industrial scale production, or more cost effective. others (see D'Amato, et al., (1994) Proc. Natl, Acad. Sci. Modifications of this type are standard in the industry and USA, 91:4082-4085; Koch et al., (1991) Agents Actions, would be readily apparent to those skilled in the art. 34:350-7: Kenyon, et al., (1996) Invest. Opthalmol. Vis. Sci. 37:1625-1632). Briefly, pellets for implantation are prepared Purification/Fractionation of Extracts and Active Ingredients from sterile hydron polymer containing a suitable amount of from Extracts of the Invention the extract. The pellets are Surgically implanted into corneal I0121 The present invention also provides for active ingre stromal micropockets created at an appropriate distance dients from the extracts of the inventions, and for purified or medial to the lateral corneal limbus of the animal. Angiogen concentrated extracts. The present invention further provides esis can be quantitated at various times after pellet implanta for methods of purifying one or more active ingredient from tion through the use of Stereomicroscopy. Typically, the the extracts of the invention. In the context of the present length of neovessels generated from the limbal vessel ring invention an “active ingredient' is a compound or molecule toward the centre of the cornea and the width of the neoves that is capable of inhibiting one or more extracellular protease sels are measured. and that demonstrates the ability to modulate one or more 0116 Similarly to the CAM assay both the Matrigel plug cellular activity. The active ingredient may be either proteina assay and the corneal micropocket assay provide some indi ceous or non-proteinaceous. “Purifying an active ingredient cation of the toxicity of the extract as the test animal is or extract indicates that the active ingredient or purified exposed to the extract. The overall health of the animal, extract can be obtained by purification, partial purification, therefore, can provide an indication of toxicity. and/or fractionation of an extract of the invention. 0117 The ability of the extract to inhibit the migration of 0.122 There are a number of techniques well known in the neoplastic cells in vivo can be determined using various mod art for isolating active components from mixtures. For els of experimental metastasis known in the art. Typically, this example, purification, partial purification, and/or fraction involves the treatment of neoplastic cells with the extract ex ation can be performed using Solid-liquid extraction, liquid Vivo and Subsequent injection or implantation of the cells into liquid extraction, solid-phase extraction (SPE), membrane a suitable test animal. The spread of the neoplastic cells from filtration, ultrafiltration, dialysis, electrophoresis, solvent the site of injection, for example spread to the lungs and/or concentration, centrifugation, ultracentrifugation, liquid or lymphoid nodes, is then monitored over a suitable period of gas phase chromatography (including size exclusion, affinity, time by standard techniques. etc.) with or without high pressure, lyophilisation, evapora tion, precipitation with various “carriers' (including PVPP Additional Tests carbon, antibodies, etc.), or various combinations thereof. 0118. In addition to the above tests, potential pre-extracts/ One skilled in the art, would appreciate how to use such extracts or extracts of the invention may be submitted to other options, in a sequential fashion, in order to enrich each Suc standard tests, such as those for the assessment of cytotoxic cessive fraction in the activity of interest by following its ity, stability, bioavailability and the like. Such tests may be activity throughout the purification procedure. Typically, the conducted prior to testing potential pre-extracts/extracts for activity is the inhibitory activity against an extracellular pro their ability to modulate cellular activity or they may be tease of interest and can be measured using assays such as conducted once an extract of the invention has been selected. those described above. As will be readily apparent to one skilled in the art, a selected I0123 Solid-liquid extraction means include the use of extract will need to meet certain criteria in order to be suitable various solvents in the art, and includes the use of Supercriti for in Vivo use and to meet regulatory requirements. Conduct cal solvents, SOXhlet extractors, Vortex shakers, ultrasounds ing such tests, therefore, allows the suitability of an extract for and other means to enhance extraction, as well as recovery by in vivo use to be assessed. Similarly, once an extract has been filtration, centrifugation and related methods as described in found to be suitable for animal administration, its efficacy the literature (see, for example, R. J. P. Cannell, Natural may be determined by standard in vivo tests and clinical trials. Products Isolation, Humana Press, 1998). Examples of sol vents that may be used include, but are not limited to, hydro Commercial Processes for Preparing Extracts of the Inven carbon Solvents, chlorinated solvents, organic esters, organic tion ethers, alcohols, water, and mixtures thereof. In the case of Supercritical fluid extraction, the invention also covers the use 0119 The present invention contemplates the large-scale of modifiers such as those described in V. H. Bright (Super preparation of selected extracts of the invention. Such critical Fluid Technology, ACS Symp. Ser. Vol. 488, ch. 22, extracts can be prepared on a commercial scale by repeating 1999). Liquid-liquid extraction means include the use of vari the extraction process that lead to the isolation of the extract ous mixtures of solvents known in the art, including solvents of interest. One embodiment of this aspect of the invention is under Supercritical conditions. Typical solvents include, but presented in FIG. 3. In this embodiment, the small-scale are not limited to, hydrocarbon solvents, chlorinated Solvents, extraction procedure is simply scaled-up and additional steps organic esters, organic ethers, alcohols, water, various aque of quality control are included to ensure reproducible results ous solutions, and mixtures thereof. The liquid-liquid extrac for the resulting extracts. tion can be effected manually, or it can be semi-automated or 0120 Also contemplated by the present invention are completely automated, and the solvent can be removed or modifications to the Small-scale procedure that may be concentrated by standard techniques in the art (see, for required during scale-up for industrial level production of the example, S. Ahuja, Handbook of Bioseparations, Academic extract. Such modifications include, for example, alterations Press, 2000). US 2009/0263516 A1 Oct. 22, 2009

0.124 Solid-phase extraction (SPE) techniques include the fractionation and/or purification of active ingredients or use of cartridges, columns or other devices known in the art. extracts (see, for example, W. D. Conway, R. J. Petroski, The sorbents that may be used with such techniques include, Modern Countercurrent Chromatography, ACS Symp. Ser. but are not limited to, silica gel (normal phase), reverse-phase Vol. 593, 1995). Solvent removal and/or concentration can be silica gel (modified silica gel), ion-exchange resins, and fluo effected by various means known in the art including, but not risil. The invention also includes the use of Scavenger resins limited to, reduced pressure evaporation, evaporation, or other trapping reagents attached to Solid Supports derived reduced pressure distillation, distillation, and lyophilization. from organic or inorganic macromolecular materials to 0.130. The present invention includes the fractionation, remove selectively active ingredients or other constituents partial purification, and purification of active ingredients or from the extracts. extracts by expandedbed chromatography, moving and simu 0125 Membrane, reverse osmosis and ultrafiltration lated moving bed chromatography, and other related methods means include the use of various types of membranes known known in the art (see, for example, G. Sofer, L. Hagel, Hand in the art, as well as the use of pressure, vacuum, centrifugal book of Process Chromatography, Academic Press, 1997 and force, and/or other means that can be utilised in membrane S. Ahuja, Handbook of Bioseparations, Academic Press, and ultrafiltration processes (see, for example, S. Ahuja, 2000). Handbook of Bioseparations, Academic Press, 2000). I0131 Selective precipitation means includes the use of 0126 Dialysis means include membranes having a various solvents and solvent combinations, the use of tem molecular weight cut-off varying from less than about 0.5 perature changes, the addition of precipitant and/or modifiers, KDa to larger than about 50 KDa. The invention also covers and/or modification of the pH by addition of base or acid to the recovery of purified and/or fractionated extracts from effect a selective precipitation of active ingredients or other either the dialysate or the retentate by various means known in constituents. the art including, but not limited to, evaporation, reduced 0.132. The invention also includes the fractionation, partial pressure evaporation, distillation, vacuum distillation, and purification, and/or purification of active ingredients and lyophilization. extracts by steam distillation, hydrodistillation, or other 0127 Chromatographic means include various means of related methods of distillation known in the art (see, for carrying out chromatography known by those skilled in the example, L. M. Harwood, C. J. Moody, Experimental art and described in the literature (see, for example, G. Sofer, Organic Chemistry, Blackwell Scientific Publications, UK, L. Hagel, Handbook of Process Chromatography, Academic 1989). Press, 1997). Examples include, but are not limited to, regular I0133. The process of purifying the active ingredients or column chromatography, flash chromatography, high perfor extracts also includes the concentration of purified or par mance liquid chromatography (HPLC), medium pressure liq tially purified active ingredients or extracts by solvent uid chromatography (MPLC), supercritical fluid chromatog removal of the original extract and/or fractionated extract, raphy (SFC), countercurrent chromatography (CCC), and/or purified extract. The techniques of solvent removal are moving bed chromatography, simulated moving bed chroma known to those skilled in the art and include, but are not tography, expandedbed chromatography, and planar chroma limited to, rotary evaporation, distillation (normal and tography. With each chromatographic method, examples of reduced pressure), centrifugal vacuum evaporation (speed sorbents that may be used include, but are not limited to, silica vac), and lyophilization. gel, alumina, fluorisil, cellulose and modified cellulose, Vari 0.134 Purified, partially purified and/or concentrated ous modified silica gels, ion-exchange resins, size exclusion active ingredients and extracts can be tested for their ability to gels and other sorbents known in the art (see, for example, T. inhibit one or more extracellular protease and to modulate Hanai, HPLC. A Practical Guide, RSC Press, UK 1999). The cellular activity according to the one or more of the proce present invention also includes the use of two or more solvent dures described above. gradients to effect the fractionation, partial purification, and/ or purification of said active extracts by chromatographic Formulations and Pharmaceutical Compositions methods. Examples of solvents that may be utilised include, 0.135 The present invention further provides for formula but are not limited to, hexanes, pentane, petroleum ethers, tions and pharmaceutical compositions comprising one or cyclohexane, heptane, diethyl ether, methanol, ethanol, iso more extract of the invention, one or more active ingredient, propanol, propanol, butanol, isobutanol, tert-butanol, water, or a combination thereof. dichloromethane, dichloroethane, ethyl acetate, tetrahydro 0.136 The formulations and pharmaceutical compositions furan, dioxane, tert-butyl methyl ether, acetone, and 2-bu of the invention comprise extracts and/or active ingredients tanone. When water or an aqueous phase is used, it may capable of inhibiting one or more extracellular protease and contain varying amounts of inorganic or organic salts, and/or modulating one or more cellular activity. In one embodiment the pH may be adjusted to different values with an acid or a of the invention, the formulations and pharmaceutical com base Such that fractionation and/or purification is enhanced. positions comprise extracts and/or active ingredients capable 0128. In the case of planar chromatography, the present of slowing down, inhibiting or preventing endothelial or neo invention includes the use of various forms of this type of plastic cell migration. In general, the extract or active ingre chromatography including, but not limited to, one- and two dient has the capacity to inhibit at least one of the active dimension thin-layer chromatography (1D- and 2D-TLC), proteases involved in the physiological process being tar high performance thin-layer chromatography (HPTLC), and geted, i.e. preventing endothelial or neoplastic cell migration, centrifugal thin-layer chromatography (centrifugal TLC). with a good inhibition constant (K). The formulations and 0129. In the case of countercurrent chromatography pharmaceutical compositions must also have acceptable tox (CCC), the present invention includes the use of manual, icity and stability. In addition, if the formulation is adminis semi-automated, and automated Systems, and the use of vari tered by different means other than topically (e.g. via oral, ous solvents and solvent combinations necessary to effect intraperitoneal, intravenous, Subcutaneous, intramuscular US 2009/0263516 A1 Oct. 22, 2009

etc. routes), then the extract and/or active ingredient must used herein includes Subcutaneous injections, intravenous, demonstrate acceptable hepatotoxicity and must be suffi intramuscular, intrasternal injection or infusion techniques. ciently resistant to degradation to allow the site of action to be One or more extract and/or active ingredient may be present reached. Finally, the formulation or pharmaceutical compo in association with one or more non-toxic pharmaceutically sition must be formulated in a manner to enable administra acceptable carriers and/or diluents and/or adjuvants and, if tion to the animal in need of treatment. Testing for the above desired, other active ingredients. The pharmaceutical compo parameters and formulation of appropriate compositions and sitions containing one or more extract and/or active ingredi formulations can be readily achieved by one skilled in the art. ent may be in a form suitable for oral use, for example, as 0.137 The formulation or pharmaceutical composition tablets, troches, lozenges, aqueous or oily Suspensions, dis may be in a solid or liquid form, for example, a cream, gel or persible powders or granules, emulsion hard or soft capsules, ointment (for a topical application), or gel-cap, tablet or cap or syrups or elixirs. sule (for oral administration), or other formulation suitable 0144. Formulations intended for oral use may be prepared for administration to an animal. according to methods known in the art for the manufacture of 0138 Criteria which must be considered in the preparation pharmaceutical compositions and Such compositions may of a formulation include, but are not limited to, the physico contain one or more agents such as Sweetening agents, fla chemical and biochemical characteristics (bioavailability, Vouring agents, colouring agents and preserving agents in toxicity, stability, etc.) of the extracts and/or active ingredi order to provide pharmaceutically elegant and palatable ents which make up the formulation. In particular, the formu preparations. Tablets contain the extracts and/or active ingre lation is prepared so as to preserve, as much as possible, the dients in admixture with non-toxic pharmaceutically accept maximum inhibitory activity of the active components upon able excipients which are suitable for the manufacture of administration, without being harmful to the animal. In one tablets. These excipients may be, for example, inert diluents, embodiment, the overall capacity for inhibition of proteolytic Such as calcium carbonate, Sodium carbonate, lactose, cal activity in the formulation correlates with the proteolytic cium phosphate or Sodium phosphate: granulating and disin overactivity profile of the biological condition being targeted, tegrating agents for example, corn starch, or alginic acid: i.e. cell migration. binding agents, for example starch, gelatine or acacia, and 0139 Pharmaceutical compositions may beformulated by lubricating agents, for example magnesium Stearate, Stearic mixing the extracts and/or active ingredients together with a acid or talc. The tablets may be uncoated or they may be physiologically acceptable carrier, excipient, binder, diluent, coated by known techniques to delay disintegration and etc. Alternatively, the extracts and/or active ingredients can be absorption in the gastrointestinal tract and thereby provide a formulated independently and the respective formulations Sustained action over a longer period. For example, a time can then be extemporaneously admixed using a diluent or the delay material Such as glyceryl monostearate or glyceryl dis like and administered, or can be administered independently tearate may be employed. of each other, either concurrently or at Staggered times to the 0145 Formulations for oral use may also be presented as same Subject. hard gelatine capsules wherein the active ingredient is mixed 0140. One embodiment of the invention relates to the with an inert Solid diluent, for example, calcium carbonate, preparation of pharmaceutical compositions comprising a calcium phosphate or kaolin, or as Soft gelatine capsules therapeutically effective amount of the above said active wherein the active ingredient is mixed with water or an oil material or mix of active materials and a pharmaceutically medium, for example peanut oil, liquid paraffin or olive oil. acceptable carrier, diluent, vehicle, or excipient. The pharma 0146 Aqueous Suspensions contain extracts and/or active ceutical compositions according to the invention may be ingredients in admixture with excipients suitable for the adapted for oral (capsules tablets, phials, etc.), parenteral, manufacture of aqueous Suspensions. Such excipients are rectal, inhalation, or topical administration, including Suspending agents, for example, Sodium carboxymethylcel creams, gels, etc. and may be in unit dosage form. Also, the lulose, methyl cellulose, hydropropylmethylcellulose, composition may be adapted for slow release in Vivo as Sodium alginate, polyvinylpyrrolidone, gum tragacanth and known in the art. gum acacia: dispersing or wetting agents may be a naturally 0141. The pharmaceutical compositions of the invention occurring phosphatide, for example, lecithin, or condensation may be used in conventional formulations including, but not products of an alkylene oxide with fatty acids, for example limited to, Solutions, syrups, emulsions, injectables, tablets, polyoxyethyene Stearate, or condensation products of ethyl capsules, suppositories, hydrophobic and hydrophilic creams ene oxide with long chain aliphatic alcohols, for example and lotions. hepta-decaethyleneoxycetanol, or condensation products of 0142. In another embodiment, the invention relates to the ethylene oxide with partial esters derived from fatty acids and preparation of herbal and nutraceutical formulations com a hexitol Such as polyoxyethylene Sorbitol monooleate, or prising extracts and/or active ingredients or Solid parts of the condensation products of ethylene oxide with partial esters plant(s) from with the extracts were obtained. For nutraceu derived from fatty acids and hexitol anhydrides, for example tical formulations comprising solid parts of plant(s), the plant polyethylene Sorbitan monooleate. The aqueous Suspensions (s) must be an edible plant. The extracts and/or active ingre may also contain one or more preservatives, for example dients or plant parts can be used in these herbal remedies and ethyl, or n-propyl p-hydroxy-benzoate, one or more colour nutraceutical compositions as Solutions, purified solutions, or ing agents, one or more flavouring agents or one or more dry powders after treatments such as those described below. Sweetening agents, such as Sucrose or saccharin. 0143. The formulations and compositions of the present 0147 Oily suspensions may be formulated by suspending invention may be administered orally, topically, parenterally, the extracts and/or active ingredients in a vegetable oil, for by inhalation or spray or rectally in dosage unit formulations example, arachis oil, olive oil, Sesame oil or coconut oil, or in containing conventional non-toxic pharmaceutically accept a mineral oil such as liquid paraffin. The oily Suspensions may able carriers, adjuvants and vehicles. The term parenteral as contain a thickening agent, for example beeswax, hard par US 2009/0263516 A1 Oct. 22, 2009 affin or cetyl alcohol. Sweetening agents such as those set to be capable of metastasizing. The extracts, active ingredi forth above, and flavouring agents may be added to provide ents, formulations orpharmaceutical compositions are, there palatable oral preparations. These compositions may be pre fore, useful in slowing down the migration or invasion of served by the addition of an anti-oxidant such as ascorbic endothelial or neoplastic cells in a variety of animal tissues. acid. 0153. To gain a better understanding of the invention 0148 Dispersible powders and granules suitable for described herein, the following examples are set forth. It preparation of an aqueous Suspension by the addition of water should be understood that these examples are for illustrative provide the extracts and/or active ingredients in admixture purposes only. Therefore, they should not limit the scope of with a dispersing or wetting agent, Suspending agent and one this invention in any way. or more preservatives. Suitable dispersing or wetting agents and Suspending agents are exemplified by those described EXAMPLES above. Additional excipients, for example, Sweetening, fla vouring and colouring agents, may also be present. Example I 0149 Pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions. The oil phase Preparation of Stressed and Non-Stressed Plant may be a vegetable oil, for example, olive oil or arachis oil, or Extracts a mineral oil, for example liquid paraffin or mixtures of these. 0154 Pre-Harvest Treatment: Aerial parts of a living plant Suitable emulsifying agents may be naturally-occurring are sprayed with an aqueous solution of gammalinolenic acid gums, for example, gum acacia or gum tragacanth, naturally (6,9,12-Octadecatrienoic acid, Sigma L-2378) (stress G) or occurring phosphatides, for example Soybean, lecithin, and arachidonic acid (5,8,11,14-Eicosatetraenoic acid, Sigma esters or partial esters derived from fatty acids and hexitol, A-3925) (stress A) (400 uMinwater with 0.125%(v/v) Triton anhydrides, for example Sorbitan monoleate, and condensa X-100) to completely cover the leaves. Twenty to twenty-four tion products of the said partial esters with ethylene oxide, for hours after the stress, plants are harvested. example polyoxyethylene Sorbitan monoleate. The emul sions may also contain Sweetening and flavouring agents. Harvest Solid S1 and Optional Storage Treatment 0150 Syrups and elixirs may be formulated with Sweet ening agents, for example, glycerol, propylene glycol, Sorbi 0155 Twenty to twenty-four hours after the stress, more tol or Sucrose. Such formulations may also contain a demul than 4 grams of leaves, stems, fruit, flowers, seeds or other cent, a preservative and flavouring and colouring agents. The plant parts are harvested and frozen immediately in dry ice, pharmaceutical compositions may be in the form of a sterile then transferred as soon as possible to a -20°C. freezer until injectable aqueous or oleaginous Suspension. This suspen use. Plant materials may be stored at -20C for a long period sion may be formulation according to methods known in the of time, more than a year, without losing inhibitory activity. art using Suitable dispersing or wetting agents and Suspending Temperature is monitored to ensure a constant condition. agents such as those mentioned above. The sterile injectable 0156 Stressed and non-stressed plant specimens are col preparation may also be sterile injectable solution or Suspen lected as wet samples and stored at -20°C. for various peri sion in a non-toxic parentally acceptable diluent or solvent, ods of time, and are submitted to a process which generates 3 for example as a solution in 1,3-butanediol. Among the Subfractions: aqueous, ethanolic and organic fractions. The acceptable vehicles and solvents that may be employed are complete extraction process is performed in a continuous water, Ringer's solution and isotonic sodium chloride solu cycle using the following steps. An initial 5 g of plant speci tion. In addition, Sterile, fixed oils are conventionally men is homogenized in liquid nitrogen with a blender. The employed as a solvent or Suspending medium. For this pur resulting powder is weighed. pose any bland fixed oil may be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic Extraction Process I: Aqueous Extraction acid find use in the preparation of injectables. 0157 To each 4.5 grams of plant powder, 12 ml of a cold solution of 100 mM Tris, pH 7.0 is added. The mixture is Use thoroughly vortexed for 2 minutes. The mixture is kept on ice 0151. The present invention further provides for the in for 30 minutes and vortexed after each 10 minute period of vivo use of the extracts of the invention and/or active ingre time. The sample is centrifuged in a CorexTM30 ml tube for 5 dients derived from the extracts, and formulations and phar minutes at 4500rpm. The resulting Supernatant is decanted in maceutical compositions comprising extracts and/or active a 15 ml tube after filtration with a MiraclothTM filter. This ingredients. Thus, the extracts, active ingredients, formula extract is therefore referred as the Potential Pre-Extract A. tions or pharmaceutical compositions can be administered to The pellet, referred as Solid S2, is kept for ethanolic extrac an animal in order to slow down, inhibit or prevent undesir tion. able migration of endothelial and/or neoplastic cells and to 0158. The aqueous extract (Potential Pre-Extract A) is ameliorate conditions associated therewith. For example, the further purified in order to determine its extracellular protease extracts, active ingredients, formulations or pharmaceutical inhibition capability. The Potential Pre-Extract A is purified compositions can be administered to an animal in order to by size-exclusion chromatography, wherein the aqueous slow down angiogenesis, neovascularisation or tumour extract is chromatographed on a calibrated Sephadex G-25 metastasis. column (1x10 cm) using a 20 mM Tris-HCl, 150 mM NaCl, 0152. As is known in the art, a variety of tissues, or organs pH 7.5 buffer as eluant. Fractions corresponding to com comprised of organised tissues, can Support angiogenesis pounds that seem to have a molecular weight (MW) less than including skin, muscle, gut, connective tissue, joints, bones 1500 daltons (D) are pooled to constitute the purified aqueous and the like in which blood vessels can invade upon angio extract that is tested for inhibitory activity in an assay as genic stimuli. In addition, a variety of tumour types are known described in Example II. US 2009/0263516 A1 Oct. 22, 2009

0159. Prior to this analysis, the extract is treated with 10% completed with solution A (final volume of 2 ml) and this gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw.) in fraction is used directly in assays as described in Example II. order to remove unspecific enzyme ligands. To 1 mL of Example II extract, 100 uL of gelatin-Sepharose resin is added in a In vitro Enzyme Inhibition Assays microassay tube, the solution in the tube is mixed, kept on ice 0164. The inhibitory activity of sample compositions for 30 minutes, and then centrifuged 5 minutes at 5,000 rpm. towards human MMP-1, human MMP-2, human MMP-3, The Supernatant is removed and used directly for assays. human MMP-9, human cathepsin-B, human cathepsin-D. human cathepsin-G, human cathepsin-L, human cathepsin Extraction Process II: Alcoholic Extraction K., human leukocyte elastase (HLE), bacteria clostripain and bacteria Subtilisin can be determined using either fluorogenic (0160. To the pellet, Solid S2, collected from the previous substrates or the FASC assay. aqueous extraction, 12 ml of cold ethanol:methanol (85:15) is Measurement of Human MMP-1, -2, -3 and -9 Activity with added and the mixture is thoroughly vortexed for 2 minutes. Fluorogenic Peptidic Substrates The mixture is kept on ice for 30 minutes and vortexed every 0.165 MMP-1, -2, -9 are purified from natural sources 10 minutes. The sample is centrifuged in a CorexTM 30 ml (human immortalized cell lines: 8505C (Deutsche Sammlung tube for 5 minutes at 4,500 rpm. The resulting supernatant is von Mikroorganismen und Zellkulturen GmbH) for MMP-1, decanted in a 15 ml tube after filtration with a MiraclothTM HT-1080 (ATCC, Manassas, Va.) for MMP-2 and THP-1 filter. The pellet, referred as Solid S3 is kept for the subse (ATCC, Manassas, Va.) for MMP-9) as described in literature and based on protocols found in I. M. Clark: <>, Humana Press (2001). Recom the Potential Pre-Extract B. binant human MMP-3 is overexpressed in E. coli and purified (0161 The ethanolic extract, Potential Pre-Extract B, is according to Windsor L. J. Steele DL (2001), Methods Mol purified by liquid/liquid extraction prior to analysis by enzy Biol 151:191-205. Proteolytic activity of these proteases is matic assay. For this purpose, 1 ml of ethanolic extract is evaluated with the assay based on the cleavage of auto evaporated under vacuum, dissolved in 150 ul of dimethyl quenched peptide substrate: (MCA-Pro-Leu-Gly-Leu-Dpa sulfoxide (DMSO), and completed to a final volume of 1.5 ml Ala-Arg-NH.TFA Dpa —N-3-(2,4-dinitrophenyl)-L-2,3- with Tris buffer (final concentration: Tris-HCl 20 mM; pH diaminopropionyl) for MMP-1, -2, and -9; and, MCA-Arg 7.5). Four ml of hexane is added to the Tris phase in a glass Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)—NH tube and the tube is thoroughly vortexed, then allowed to form (DNP-2,4-dinitrophenyl; Nva=L-norvaline) for MMP-3 a biphasic liquid. The organic phase is removed and the (Calbiochem, San Diego, Calif.). In the intact peptide. Dpa or extract is Submitted to a second round of liquid/liquid extrac DNP quenches the MCA fluorescence. Cleavage of the pep tion. The aqueous phase is removed and treated with 10% tide causes release of the fluorescent MCA group which is gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw) to then quantitated on a fluorometer (Gemini XS, Molecular remove unspecific enzyme ligands prior to conducting Sub Devices, Sunnyvale, Calif.). The assay is performed in TNCZ sequent assays. To 1 ml of extract, 1001 L of gelatin assay buffer (20 mM Tris-HCl, NaCl 150 mM: CaCl, 5 mM: Sepharose resin is added in a microassay tube, the tube is ZnCl2 0.5 mM; pH 7.5) with human purified proteases (I. M. mixed, kept on ice for 30 minutes, and then centrifuged 5 Clark: Matrix metalloproteinases protocols, Humana Press minutes at 5,000 rpm. Supernatant is removed and used (2001)). The substrate, primarily dissolved in DMSO is then directly for assays as described in Example II. redissolved in TNCZ buffer for the assay. In a typical assay, 10 ul of purified enzyme (1-50 ng) and 5 ul of dissolved Extraction Process III: Organic Extraction substrate (final concentration of 10 uM) is mixed in a final volume of 75 ul (completed with TNCZ). All assays were 0162 To the pellet, Solid S3, collected from previous etha performed in 96 well plate and the reaction is started by the nolic extraction, 12 ml of cold dichloromethane is added and addition of substrate. Assays are measured (excitation 325 the mixture is thoroughly vortexed for 2 minutes. The mixture nm, emission 392 nm) for 20, 40 and 60 minutes. is kept on ice for 30 minutes and vortexed after each 10 Measurement of Human Cathepsin L and K Activity with minutes period. The sample is centrifuged in a CorexTM30 ml Fluorogenic Peptidic Substrate. tube for 5 minutes at 4,500 rpm. The resulting supernatant is 0166 Human recombinant cathepsins L and K are over decanted in a 15 ml glass tube after filtration with a Mira expressed in P. pastoris according to the protocol described clothTM filter. The final pellet is discarded. The organic sol by Krupa and Mort (Anal Biochem (2000), 283(1):99-103). vent is evaporated under vacuum and the phase is dissolved The assay is similar to that described above except for the with dimethylsulfoxide (DMSO). This extract is therefore auto-quenched peptidic substrate: Z-Arg-Phe-AMC, 2HCl referred as the Potential Pre-Extract C, which was further (Bachem California, Torrance, Calif.) and reaction buffer. purified by Solid phase extraction prior to analysis by enzy Assays for Cathepsin L are performed in 20 mM acetate pH matic assay. 5.5, 1 mM EDTA buffer and assays for Cathepsin Kin 20 mM 0163. In order to assay the Potential Pre-Extract C, the acetate pH 4.2, 1 mM EDTA. Assays are monitored with organic extract is diluted 1:10 in a solution of DMSO:Metha fluorometer settled at excitation 380 nmfemission 460 nm. nol:Tris (20 mM, pH 7.5) (10:50:40) (Solution A), i.e., 220 wavelengths (Krupa J C. Mort J S. (2000), Anal Biochem ul of extract is added to 2.0 ml of solution A. After 10 seconds 283(1):99-103). of vigorous vortex, the mix is sonicated for 10 seconds. Dis Solved extracts are Subsequently applied to a solid phase Measurement of Human MMP-9, Cathepsin B, Cathepsin G, extraction plate (Discovery SPE-96, Sigma Chemical Co. and Human Leukocyte Elastase (HLE) Activity. Using the St-Louis, Mo.). After initial conditioning of the columns with FASC Assay 1 ml of methanol, columns are equilibrated with Solution A, 0.167 Human Cathepsin B and G and human leukocyte and extract samples are deposited on the columns. Elution is elastase are obtained from Calbiochem (San Diego, Calif.). US 2009/0263516 A1 Oct. 22, 2009

Human MMP-9 is purified as previously described. The assay tion is performed and samples are treated with 1:10 of gelatin is based on the method described in Canadian Patent No. Sepharose 4BTM to remove quenching. 2,189,486 (1996) and by St-Pierre et al., (Cytometry (1996) 0172. In a typical fluorescent assay, 10 ul of purified 25:374-380. For the assay, 5ul of the purified enzyme (1-100 enzyme at concentrations previously mentioned for the enzy ng), 5ul of concentrated buffer solution (20 mM Tris-HCl; matic assay, 5ul of dissolved fluorogenic peptide or 10 Jul of NaCl 150 mM: CaCl, 5 mM, ZnC10.5 mM; pH 7.5), and 5ul dissolved fluorescent proteic substrate (final concentration of of gelatin-FITC beads are typically used in a final volume of 10LM) and 40LL of the aqueous, ethanolic or organic extract 100 ul. The assay is performed by incubation of the reaction to be tested and prepared as described in Example I are mixed mixture for 90 minutes at 37°C. The reaction is stopped by in a final volume of 75 ul (completed with TNCZ for fluoro the transfer of the mix in 0.5 ml of 20 mM Tris, 150 mMNaCl; genic peptide substrate assay or 20 mM citrate pH 3.3 buffer pH 9.5 buffer. This tube is analyzed in a flow cytometer (Epics for fluorescent protein Substrate assay). All assays are per MCL. Beckman Coulter, Mississauga, Ontario) as described formed in 96 well plate and the reaction is started by the in Canadian Patent No. 2,189,486 (1996). addition of substrate. Assays are measured (excitation 325 Measurement of Human Cathepsin D. Cathepsin B, Cathep nm, emission 392 nm for peptide and excitation 488 mm/emis sin G and HLE Activity with a Fluorogenic Proteic Substrate sion 525 nm wavelengths for protein) for 20, 40 and 60 0168 Cathepsin D is purified from human MCF-7 cells minutes. Activity and inhibition values are determined from according to the method described by Stewart et al., (Int J the increase in fluorescence Cancer (1994) 57(5):715-8. Cathepsin B, Cathepsin G and (0173 For the FASC assay, 35 ul of the treated extract HLE are obtained as previously described. The activities of prepared as described in Example 1, 5 ul of the purified Cathepsin D. Cathepsin B, Cathepsin G and HLE are mea enzyme prepared as described previously, 5 Jul of concen Sured by an assay based on the increase of fluorescence of a trated buffer solution (TNCZ), and 5ul of gelatin-FITC beads proteic substrate (Haemoglobin in the case of Cathepsin D are typically used. The initial step of the assay is the incuba and B and beta-casein in the case of Cathepsin G and HLE) tion of the reaction without beads for a 30 minutes period on heavily labelled with Alexa-488 dye (Molecular Probes, ice to allow the binding of inhibitors to enzyme. Fluorescent Eugene, Or). The substrate, when highly labelled with the beads are added and the reaction mix is incubated for 90 dye, will almost quench the dye fluorescence. Cleavage of the minutes at 37°C. The reaction is stopped by transfer of the substrate will result in an increase of the fluorescence which mix in 0.5 ml of 20 mM Tris, 150 mM NaCl; pH 9.5 buffer. can be measured with a spectrofluorometer, and which is This tube is analyzed in the flow cytometer (Epics MCL, proportional to protease activity. Typically, 10ul of purified Beckman Coulter, Mississauga, Ontario) as described in human Cathepsin D. Cathepsin B, Cathepsin G or HLE (10 Canadian Patent Application No. 2,189,486 (1996). 50 ng) and 10 uL of Hemoglobin-Alexa488 or beta-casein 0.174 Results of the inhibition studies are shown in Tables Alexa488 (100 ng) are assayed in final volume of 75 ul 1-12 for aqueous (A), ethanolic (R) and organic (S) extracts adjusted with 20 mM citrate pH 3.3 buffer in the case of from exemplary stressed (A and G) and non-stressed (T) plant Cathepsins D and B or TNCZ buffer in the case of Cathepsin sources. The inhibition is reported as percentage (%) of inhi G and HLE. The reaction is performed as already described bition of Substrate degradation as compared with the degra except that the fluorescence is read at excitation 488 mm/emis dation without extract. sion 525 nm wavelengths. Table 1: inhibition of human MMP-1. Table 2: inhibition of human MMP-2. Subtilisin Assay Table 3: inhibition of human MMP-3. 0169. Subtilisin (isolated from B. subtilis) is purchased Table 4: inhibition of human MMP-9. from Fluka. Assays are performed with a fluorogenic peptide Table 5: inhibition of human Cathepsin B. (Z-Gly-Gly-Leu-AMC, Bachem California, Torrance, Calif.) Table 6: inhibition of human Cathepsin D. as already described for MMPs with the following modifica Table 7: inhibition of human Cathepsin G. tion: the assay is buffered with 20 mM Tris, 150 mM. NaCl; Table 8: inhibition of human Cathepsin L. pH 7.5 and the results are read at excitation 380 nm/emission Table 9: inhibition of human Cathepsin K. 460 nm wavelengths. Table 10: inhibition of HLE. Table 11: inhibition of bacterial subtilisin. Clostripain Assay Table 12: inhibition of bacterial clostripain. 0170 Clostripain from Clostridium histolyticum (Wor thington Lakewood, N.J.) is prepared and activated as Example III described by manufacturer's protocol. The activity is deter mined by using Z-Arg-Arg-AMC, 2HCl (Calbiochem, San Exemplary Purification of Inhibitory Activity Found Diego, Calif.) as a fluorogenic peptidic Substrate and the in an Extract incubation buffer is 75 mM phosphate, pH 7.6. The reaction is performed as already described except that the fluorescence is 0.175 Extracts were separated by HPLC on an Agilent read at excitation 380 nm/emission 460 nm wavelengths. 1100 system (San Fernando, Calif.). Briefly, 100 uL of a crude extract prepared as described in Example I was applied Extract Inhibition Assay on a C18 reverse-phase column (Purospher RP-18 5 um, 4.0x125 mm (HP), Agilent, San Fernando, Calif.). Elution of 0171 Before a typical assay, aqueous extracts prepared as compounds was achieved with a linear gradient of 10-85% described in Example I are preincubated with 1:10 of gelatin acetonitrile. Fractions were collected, evaporated, resus Sepharose 4BTM for 30 minutes to remove fluorescence pended in aqueous buffer and then reanalysed for their inhi quenching. For the ethanolic extract, an initial hexane extrac bition activity on specific enzymes as already described. US 2009/0263516 A1 Oct. 22, 2009 20

Fractions of interest (demonstrating a biological activity) 0179 The percent inhibition of migration is calculated as where then reisolated at a larger scale for further analysis and follows: characterisation. (A-B)/Ax100, where A is the average number of cells per field in the control Example IV well and B is the average number of cells per field in the treated wells. Effect of Plant Extracts on Cell Migration 0180 For cancer cell lines, prior to starting the experi ment, the Matrigel impregnated filter was rehydrated with 0176 Plant extracts were prepared as described in 200 ul of DMEM. A mixture of cells (100 ul of 2.5x10/ml Example I and underwent further testing to ascertain that they HT1080 or MDA-MB-231 cells, both from ATCC) and plant contain stable, orally bioavailable, non-cytotoxic molecules extracts were pipetted into the upper wells and 700 ul of that are appropriate for product development. Stability is DMEM-5% SVF was added to the bottom wells. The cells ascertained by recovery of protease inhibition over time were incubated for 48 hours (HT1080 cells) or 72 hours under various conditions, including physiological conditions. (MDA-MB-231 cells), after which the membrane was treated Potential for oral bioavailability is ascertained by an in vitro as described above and inhibition of migration was deter test using Caco-2 cells and cytotoxicity is ascertained by mined as described above (see also FIG. 4, which shows the incubation of the extracts with various cell types, including results using an extract from Iberis Sempervirens). those indicated below. Cord Formation Assay Methods for Determination of Anti-Angiogenic and Anti 0181 Matrigel (60 ul of 10 mg/ml) was added to a 96-well Invasive Effects of Plant Extracts plate flat bottom plate (Costar 3096) and incubated for 30 minutes at 37° C. in a 5% CO atmosphere. A mixture of 0177. In order to test the effect of various plant extracts HUVECs and plant extract, or positive controls (Fumagillin that are also validated protease inhibitors on cellular migra and GM6001) were added to each well. HUVECs were pre tion, the following cellular assays were used: a cellular migra pared as suspensions of 2.5x10 cells per ml in EGM-2, then tion assay coupled with a cord formation assay using endot 500 ul of HUVECs preparation was mixed with 500 ul of 2x helial cells; and a cellular migration assay using one of 2 of the desired dilution of plant extract or control drug and 200 neoplastic cell lines. The experimental details are provided ul were added to each well. Four dilutions of each extract below and the results of the tests are set forth in Tables 13 and were tested in duplicate. After 18-24 hours at 37° C. in 5% 14. Concentrations of plant extracts are expressed as a func CO, the cells had migrated and organized into cords (see tion of the ICso concentration determined for protease inhi FIG. 5, which shows the results using an extract from Rheum bition, which is termed 1x. The extracts are, therefore, rhabarbaram). The number of cell junctions were counted in capable of decreasing the activity of at least one extracellular 3 randomly selected fields and the inhibition of cord forma protease by at least 50% when measured according to one of tion is calculated as follows: the assays described herein. The 1x concentration can vary (A-B)/Ax100, depending on the plant and the solvent used in the preparation where A is the average number of cell junctions perfield in the of the extract. The average concentration of a 1x aqueous control well and B is the average number of cell junctions per extract is about 1.6 mg/ml, whereas the average concentration field in the treated wells. of a 1x alcoholic extract is about 4 mg/ml. For each extract 0182. The invention being thus described, it will be obvi tested in the assays described below, 4 different concentra ous that the same may be varied in many ways. Such varia tions were used (0.31x, 0.62x, 1.25x and 2.5x) in duplicate. tions are not to be regarded as a departure from the spirit and Scope of the invention, and all Such modifications as would be Cell Migration Assays obvious to one skilled in the art are intended to be included 0.178 Migration was assessed using a multi-well system within the scope of the following claims. (Falcon 1185, 24-well format), separated by a PET mem brane (8 um pore size) into top and bottom sections. Depend TABLE I ing on the cells that are used in the assay, the membrane was coated with 10 ug/ml rat tail collagen (for HUVECs) or with MMP-1. Inhibition 80 g/cm of Matrigel growth factor (BD Biosciences) (for Nomlatin Stress Extrait Inhibition (%) cancer cell lines) and allowed to dry. All solutions used in top Achillea millefolium A. O 22.2 sections were prepared in DMEM-0.1% BSA, whereas all Acorus calamus A. O 1OO.O solutions used in the bottom sections were DMEM, or other Actinidia argutta A. O 56.4 media, containing 10% fetal calf serum. For HUVECs Agastache foeniculum A. S 30.4 Aichemia nois A. 4 36.4 (Clonetics), EGM-2 (700 ul) was added to the bottom cham Allium cepa A. O 61.4 ber as a chemo-attractant. HUVEC (100 ul of 10° cells/ml) Allium grande A. R 46.5 and buffer containing the plant extract at the appropriate Allium porrum A. R 2S.O dilution were added to the upper chamber (duplicate wells of Allium porrum A. O 98.9 Aium sativum A. O 42.5 each plant extract at each dilution). After 5 h incubation at 37° Aium sativum A. R 98.7 C. in a 5% CO atmosphere, the membrane was rinsed with Allium Schoenoprastin A. R 22.3 PBS, fixed and stained. The cells on the upper side of the Aium Tuberosum A. R 29.9 membrane were wiped off, three randomly selected fields Aium Tuberosum A. O 1OO.O were counted on the bottom side. US 2009/0263516 A1 Oct. 22, 2009

TABLE I-continued TABLE I-continued

MMP-1. Inhibition MMP-1. Inhibition Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Althaea officinalis 21.6 Medicago Saiiva 25.1 Angelica archangelica 45.9 Melissa officinalis 1OO.O Anthemis nobilis 34.5 Mentha piperita 60.1 Aralia nudicatiis 1OO.O Mentha suaveolens 35.1 Armoracia rusticana 31.2 Nepeta Cataria 1OO.O Armoracia rusticana 39.7 Nicotiana rustica 20.7 Aronia melanocarpa 39.8 Origantim vulgare 6O.S Aster sp 67.6 Origantim vulgare 73.2 Beckmannia eruciformis 24.1 Perilla frutescens 744 Beta vulgaris 41.2 Perilla frutescens 92.4 Beta vulgaris spp. Maritina 44.1 Petroselinum crispum 774 Brassica naptis 26.3 Phacelia tanacetifolia 52.8 Brassica oleracea 28.6 Phaseolus coccineus 20.9 Brassica oleracea 33.8 Phaseolus coccineus 34.2 Brassica Oieracea 1OO.O Phaseolus Vulgaris 29.2 Brassica rapa 61.4 Phaseolus vulgaris 56.1 Calamintha nepeta 40.2 Phaseolus Vulgaris 6O.O Cameia sinensis 39.3 Phaseolus Vulgaris 1OO.O Capsicum annittin 34.3 Phlox paniculata 1OO.O Capsicum annittin 88.3 Pimpinella anisum 1OO.O Capsicum finitescens 39.4 Pimpinella anisum 72.2 Chenopodium bonus-henricus 1OO.O Plantago Coronopus 23.7 Chenopodium bonus-henricus 37.3 Plectranthus sp. 2S.O Chenopodium quinoa 66.3 Poa compressa 31.5 Chrysanthemum coronarium 37.4 Potentiiia anserina 71.2 Cichorium intybus 22.O Pysalis ixocarpa 32.1 Cichorium intybus 66.9 Raphantis raphanistrain 31.5 Citritius ianatus 41.9 Raphantis sativits 1OO.O Cornus Canadensis 73.O Raphanus sativus 30.2 Crataegus sp 1OO.O Rheum officinale 79.1 Cuctimis Anguria 34.2 Rheum rhabarbarium 22.9 Cucurbita moschata 27.3 Rheum rhabarbarium 32.8 Cucurbitapepo 84.9 Ribes nigrum 1OO.O Cymbopogn citraits 1OO.O Ribes nigrum 1OO.O Cymbopogon citratus 22.1 Ribes Saivum 48.6 Cypertis escientiis 25.8 Ribes Sylvestre 26.5 Cypertis escientiis 28.1 Ribes tiva-crispa 1OO.O Dactylis glomerata 25.5 Rubus Canadensis 46.1 Daiiciis Caroia 43.4 Rubus Canadensis 53.1 Daiiciis Caroia 1OO.O Rubus idaeus 1OO.O Dipsactis Saivais 35.3 Salvia officianalis 1OO.O Dirca palustris 47.9 Saivia Sciarea 43.8 Erica vesicaria 33.7 Satureia montana 1OO.O Eschscholzia Californica 61.1 Soianum duticamara 43.8 Eschscholzia Californica 74.1 Soianum melanocerastin 37.2 Filipendula rubra 51.7 Soianum tuberosum 1OO.O Foeniculum vulgare 86.2 Sorghum dochna 1OO.O Fragaria Xananassa 23.7 Stachys byzantina 28.9 Fragaria Xananassa 40.6 Steiaria media 33.1 Fragaria Xananassa 28.3 Tanacetain parthenium 28.9 Gainsoga ciliata 29.7 Tanacetum vulgare 76.O Gaium odoratum 48.8 Taraxacum officinale 65.7 Gaultheria hispidula 23.9 Thymus praecox. Subsp. arcticus 642 Glycine max 24.7 Thymus praecox. Subsp. arcticus 88.2 Glycine max 29.6 Thymus vulgaris 42.7 Glycine max 1OO.O Thymus X citriodorus 34.7 Guizotia abyssinica 39.4 Trichosanthes kirillowii 31.8 Hamamelis virginiana 49.1 Trifolium hybridum 96.O Heianthus Tiberosus 95.9 Trifolium incarnatum 1OO.O Heliotropium arborescens 2S.O Trifolium pannonicum 27.7 Hordeum hexastichon 1OO.O Trifolium repens 79.5 Hordeum vulgare 46.2 Vaccini in augustifolium 52.5 Hordeum vulgare subsp. Vulgare 43.8 Vaccinum macrocarpon 64.5 Initia heienium 25.8 Vicia Saiva 60.8 Lathyrus Saivais 27.1 Vicia Saiva 28.6 Leonirits cardiaca 34.4 Vicia viliosa 64.7 Levisticum officinale 31.7 Vicia viliosa 57.3 Lolium multiflorum 39.0 Vigna sesquipedalis 33.0 Lotus corniculatus 1OO.O Vigna sesquipedalis 24.4 Malva Sylvestris 22.8 Vignatinguiculata 20.6 Matricaria recitita 25.1 Vitia spp 72.6 Matteucia pensylvanica 48.1 Vitia spp 1OO.O US 2009/0263516 A1 Oct. 22, 2009 22

TABLE I-continued TABLE I-continued

MMP-1. Inhibition MMP-1. Inhibition Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Zea Mays 99.2 Lepidium Sativum 29.5 Zea Mays 1OO.O Levisticum officinale 1OO.O Abelnochtis escientiis 37.6 Lolium multiflorum 24.9 Aconium napelius 1OO.O Lolium multiflorum 27.1 Allium ampeioprastin 33.4 Lotus corniculatus 52.2 Allium ascalonictim 31.5 Lycopersicon escientiin 24.4 Allium cepa 34.4 Lycopersicon pinpineliifolium 30.3 Allium cepa 36.4 Maius hupehensis 65.8 Aium sativum 53.2 Maiva verticiliata 43.1 Aium tuberosum 68.3 Matricaria recitita 1OO.O Althaea officiana is 47.7 Matteucia pensylvanica 57.5 Althaea officinalis 30.7 Melissa officinalis 28.5 Althaea officinalis 44.3 Mentha piperita 36.0 Althea officinalis 83.6 Mentha spicaia 20.3 Anethtingraveolens 44.3 Mentha spicaia 26.0 Apium graveolens 27.7 Mentha suaveolens 6O.S Armoracia rusticana 51.8 Nepeta Cataria 24.1 Armoracia rusticana 47.1 Nicotiana rustica 28.1 Aronia melanocarpa 66.5 Nicotiana tabacum 40.6 Artemisia dracunculus 79.0 Oenothera biennis 28.4 Artemisia dracunculus S.O.3 Oenothera biennis 1OO.O Asparagus officinalis 96.4 Origantim vulgare 1OO.O Bellis perennis 44.1 Origantim vulgare 20.1 Beta vulgaris spp. Maritina 43.7 Origantim vulgare 85.4 Beta vulgaris spp. Maritina 34.9 Oryza Sativa 53.3 Bettilagianditiosa 40.8 Panax quinquefoils 1OO.O Borago officinalis 30.3 Panicum miliaceum 1OO.O Borago officinalis 29.7 Passiflora caerula 20.9 Brassica cepicepa 21.9 Pastinaca Saiiva 68.4 Brassica oleracea 33.6 Pastinaca Saiiva 1OO.O Brassica oleracea 1OO.O Pennisetum alopectiroides 1OO.O Brassica rapa 42.5 Petroselinum crispum 73.0 Brassica rapa 40.2 Phaiaris canariensis 1OO.O Calamintha nepeta 28.7 Phaseolus coccineus 29.9 Calendula officinalis L. 1OO.O Phaseolus coccineus 67.6 Cameia sinensis 46.4 Phaseolus coccineus 32.4 Campaniiia raptinctius 27.2 Phaseolus vulgaris 33.4 Capsella bursa-pastoris 24.1 Phaseolus vulgaris 60.2 Capsicum annuin 36.0 Phaseolus vulgaris 22.3 Chaerophyllum bulbosum 38.9 Phaseolus vulgaris 87.7 Chenopodium quinoa 1OO.O Phlox paniculata 89.3 Cichorium intybus 44.6 Physalis pruinosa 37.0 Circium arvense 30.3 Plantago Coronopus 48.1 Citritius ianatus 21.2 Plantago major 47.0 Cucurbitapepo 59.5 Plectranthus sp. 97.2 Cucurbita Pepo 40.2 Potentiiia anserina 22.0 Cuminum cyminum 25.5 Prunella vulgaris 21.2 Cymbopogon citratus 33.7 Raphantis Raphanistrain 95.9 Daitira Stranonium 73.5 Raphantis sativits 67.7 Daiiciis Caroia 86.0 Reseda Odorata 40.6 Daiiciis Caroia 27.9 Rheum officinale 82.1 Dryopteris filix-mas 21.9 Rheum rhabarbarium 48.1 Erysimum perofskianum 24.4 Ribes Nigrum 1OO.O Fagopyrim esculenium 1OO.O Ribes Sylvestre 42.9 Foeniculum vulgare 28.0 Ricinits communis 73.5 Foeniculum vulgare 57.3 Rubus Phoenicaiasius 31.4 Gaultheria hispidula 44.2 Rita graveolens 1OO.O Gaultheria procumbens 94.8 Salvia officinalis 1OO.O Giechona hederacea 25.5 Santoina 28.1 Glycine max 1OO.O Satureia hortensis 1OO.O Glycyrrhiza glabra 24.9 Satureia repandra 57.1 Guizotia abyssinica 30.3 Scrophtiaria nodosa 41.6 Helenium hoopesii 28.6 Scutelaria laterifiora 72.1 Helianthus annuit is 33.6 Siim Sisartin 99.7 Heianthus tuberosus 54.4 Soianum duticamara 65.4 Hordeum vulgare 28.8 Soianum melanocerastin 32.4 Hordeum vulgare subsp. Vulgare 28.1 Soianum melogena 1OO.O Hypericum hennyl 80.0 Soianum tuberosum 46.4 Iberis amara 44.6 Sorghum cafiorum 1OO.O Lactica Saiiva 25.3 Sorghum dochna 514 Lathyrus Sylvestris 90.2 Sorghum dochna 39.6 Lavandhiia anguistifolia 22.5 Sorghum Sudanense 97.4 US 2009/0263516 A1 Oct. 22, 2009 23

TABLE I-continued TABLE I-continued

MMP-1. Inhibition MMP-1. Inhibition Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Stachys byzantina G O 41.4 Cichorium intybus S SO.6 Steiaria media G O 33.8 Cichorium intybus R 31.7 Symphytum officinale G O S2.O Cichorium intybus R S2.9 Tanacetain parthenium G O 79.1 Citritius ianatus O 1OO.O Tanacetum vulgare G O 1OO.O Citrus paradisi O 40.6 Taraxacum officinale G S 25.9 Cocos nucifera O 27.2 Teucrium chamaedrys G O 1OO.O Cornus Canadensis S 44.9 Teucrium chamaedrys G R 48.0 Crithmin maritimum R 32.3 Thymus praeco X subsp. arcticus G R 73.1 Clictimis anguria O 22.6 Thymus X citriodorus G O 52.2 Cucurbita moschata O 33.5 Trichosanthes kirillowii G O 35.9 Cucurbita moschata (Early Butternut) R 32.3 Trifolium hybridum G R 76.O Cucurbitapepo O 89.0 Trifolium incarnatum G R 73.4 Cuminum cyminum R S4.3 Trifolium pannonicum G R 24.8 Curcuna Zedoaria S 1OO.O Trifolium repens G R 48.5 Cymbopogon citratus O 42.6 Triticosecale spp. G R 48.5 Datura meiei O 24.8 Triticum spelta G R 22.9 Datura meiei R 25.5 Tropaeoluim maints G S 23.4 Dioscorea batatas R 1OO.O Urtica dioica G O 96.4 Dipsactis sativus O 85.O Vaccinium corymbosum G S 60.7 Dryopteris filix-mas O 46.4 Vaccinium corymbosum G R 61.4 Erigeron Canadensis O 1OO.O Vaccini in anglisiifolium G R 54.7 Erica vesicaria R 30.9 Vicia Saiva G R 68.8 Erysimum perofskianum O 23.0 Vicia Saiva G O 31.5 Eschscholzia Californica O 37.8 Vicia viliosa G O 1OO.O Eschscholzia Californica R 20.8 Vicia viliosa G R 35.5 Fagopyrim esculenium O 1OO.O Vigna sesquipedalis G R 23.0 Fagopyrim tariarictim R 78.5 Vitia spp G R 36.9 Foeniculum vulgare O 63.4 Withania somnifera G O 44.0 Foeniculum vulgare O 27.2 Xanthium strumarium G R 37.6 Forsythia X intermedia S 32.O Zea mays G O 1OO.O Fragaria Xananassa S 33.0 Aconium napelius R 1OO.O Gainsoga ciliata R 25.8 Agarict is bisports R S8.9 Gaultheria procumbens O 46.8 Agarict is bisports O 1OO.O Hedeona ptilegioides O 73.6 Allium ampeioprastin R 43.3 Heianthus tuberosus O 39.3 Allium ascalonictim R 34.5 Hordeum vulgare O 32.4 Allium cepa R 53.5 Huntilus lupulus O 21.1 Allium cepa O 45.8 Hypericum hennyi R 29.3 Allium grande R 43.2 Hyperictim perforatin R 42.7 Allium Schoenoprastin R 47.1 Iberis amara O 29.5 Aium tuberosum R 74.6 Ipomea aquatica R 22.9 Aium tuberosum O 33.6 Lathyrus Saiivus R 69.4 Aloe Vera R 34.1 Latiri is nobilis O 70.2 Althaea officinalis S 47.8 Lavandhiia iaiifolia O 1OO.O Amelianchierainitoia R 59.1 Lens culinaris Subsp. Culinaris O 70.2 Ananas Conostis O 1OO.O Lepidium sativum O 1OO.O Anthemis nobilis O 22.7 Levisticum officinale O 1OO.O Anthriscus cerefolium O 56.8 Lolium multiflorum O 35.1 Apium graveolens R 29.8 Linaria annia O 1OO.O Aralia nudicatiis O 1OO.O Lycopersicon pinpineliifolium R 24.4 Armoracia rusticana O S8.9 Maius hupehensis R 73.1 Artemisia dracunculus O 1OO.O Maius sp. R 80.9 Asparagus officinalis R 25.2 Malva Sylvestris R 34.7 Atriplex hortensis R 44.7 Malva Sylvestris O 1OO.O Bellis perennis R S8.1 Manihot escuienia R 33.0 Beta vulgaris R 37.3 Melissa officinalis O 1OO.O Bettilagianditiosa O 23.5 Melissa officinalis O 1OO.O Boletus eduis S 642 Mentha suaveolens S 39.7 Brassica iuncea R 35.6 Nigella Saiiva R S8.9 Brassica naptis O 1OO.O Nigella Saiiva R 1OO.O Brassica oleracea R 33.2 Ocimum Basilicum R 1OO.O Brassica oleracea O 49.7 Origantin majorana O 41.5 Cameia sinensis O 24.7 Origantim vulgare O 29.8 Cameia sinensis R 45.7 Origantim vulgare R 33.1 Canna eduis R 26.2 Panax quinquefoils R 75.2 Cartin carvi O 1OO.O Passifiora spp. S 32.O Chaerophyllum bulbosum R 40.9 Pastinaca Saiiva R 20.8 Chrysanthemun coronarium (Chip Suey) R 48.1 Perroselinum crispum R SS.4 Chrysanthemum coronarium R 29.9 Petroselinum crispum R 76.1 Chrysanthemum coronarium R 1OO.O Petroselinum crispum O 24.1 Cichorium endi via R 2O.S Peucedanum of easeinum O 21.0 Cichorium endi via R 21.9 Phacelia tanacetifolia R 48.6 US 2009/0263516 A1 Oct. 22, 2009 24

TABLE I-continued TABLE I-continued

MMP-1. Inhibition MMP-1. Inhibition

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Phaiaris canariensis 56.4 T R 20.1 Phaseolus coccineus 22.7 Zea mayS Phaseolus mingo 47.4 Zea mayS T O 32.2 Phaseolus vulgaris 40.O Phaseolus vulgaris 29.4 Phoenix dactylifera 46.3 Physalis ixocarpa goldie ou pourpre 28.9 TABLE 2 Phytolacca americana OO.O Plectranthus sp. 73.8 MMP-2 Pleurotus spp. OO.O Poa compressa 22.3 Nomlatin Stress Extrait Inhibition (%) Poa pratensis 73.1 Populus Tremula OO.O Achillea millefolium 21.9 Prunella vulgaris 38.0 Achillea millefolium 63.0 Psoralea conviifolia 96.4 Achillea millefolium 1OO.O Pteridium aquilinum OO.O Aconium napeiitis 71.O Raphantis raphanistrain OO.O Alcea rosea 67.9 Raphantis sativits 33.7 Aichemia nois 64.4 Raphantis sativits 28.0 Allium ascalonictim 20.9 Raphantis sativits OO.O Allium cepa 84.3 Reseda luteola 69.6 Allium grande 36.7 Reseda Odorata 51.8 Allium porrum 1OO.O Rheum officinale 46.7 Allium portin S1.9 Rheum officinale OO.O Allium portin 66.7 Ribes nigrum 3O.O Aium sativum 1OO.O Ribes Saiivum 61.7 Allium Schoenoprastin 73.5 Ribes Sylvestre 75.4 Aium Tuberosum 24.3 Ricinits communis OO.O Aium Tuberosum 83.6 Rosmarinus officinalis 29.0 Aium Tuberosum 89.3 Rubus Canadensis 86.1 Aloe vera 69.7 Sabai serrulata OO.O Althaea officinalis 27.6 Salvia officinalis OO.O Althaea officinalis 64.7 Sambucus Canadensis 24.8 Amaranthus gangeticits 29.4 Satureia montana OO.O Anethlin graveolens 1OO.O Satureia repandra 27.2 Apium graveolens 25.1 Satureia repandra 36.4 Apium graveolens S2.1 Satureia repandra 42.O Aralia Cordata 66.4 Scrophtiaria nodosa 68.8 Aralia Cordata 92.2 Secale cereale 1OO.O Aralia nudicatiis 29.4 Setaria itaica 23.2 Arctii in minus 28.4 Silybum marianum 73.5 Armoracia rusticana 2O2 Soianum melongena 20.1 Armoracia rusticana 55.0 Soianum tuberosum 24.4 Arrhenaiherum eiatius 40.2 Solidago virgatirea 71.4 Artemisia dractinctiitis 39.7 Sorghum dochna 22.5 Asparagus officinalis 29.3 Stachys byzantina 39.2 Atriplex hortensis 33.6 Steiaria media 43.3 Avena Saiiva 37.2 Symphytum officinale 58.7 Beta vulgaris 45.4 Tanacetain parthenium 1OO.O Beta vulgaris 95.9 Tanacetum vulgare 32.5 Beta vulgaris spp. Maritima 1OO.O Taraxacum officinale 27.8 Brassica chinensis 49.6 Teucrium chamaedrys 62.9 Brassica naptis 28.5 Teucrium chamaedrys 1OO.O Brassica Naptis 52.4 Thalipsi arvense 21.2 Brassica Naptis 82.4 Thymus praeco X subsp. arcticus 60.9 Brassica nigra 29.2 Tragopogon porrifolium 24.6 Brassica oleracea 31.2 Trifolium incarnatum 33.7 Brassica Oieracea 31.4 Trifolium pannonicum 72.4 Brassica oleracea 64.O Trifolium repens 72.4 Brassica oleracea 68.7 Triticosecale spp. 33.7 Brassica oleracea 75.3 Tropaeoluim maints 1OO.O Brassica oleracea 1OO.O Tropaeoluim maints 31.5 Brassica rapa 27.6 33.4 Vaccinium anglisiifolium 1OO.O Brassica rapa Brassica rapa 57.6 Vaccinium anglisiifolium 42.1 Brassica rapa S8.1 Vaccinium macrocarpon 30.9 Brassica rapa 84.5 Vicia viliosa 35.5 Calamintha nepeta 6S.O Vigna sesquipedalis 24.O Cameia sinensis 21.9 Vignatinguiculata 31.6 Cameia sinensis 26.5 Vinca minor 28.7 Cameia sinensis 79.0 Withania somnifera 26.9 Cana eduis 45.5 Xanthium strumarium 30.9 Canna eduis 2O2 US 2009/0263516 A1 Oct. 22, 2009

TABLE 2-continued TABLE 2-continued

MMP-2 MMP-2 Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Capsella bursa-pastoris 35.5 Glycine Max 43.1 capsicum annittin 61.5 Glycine max 1OO.O Capsicum annittin 89.8 Guizotia abyssinica 29.8 Capsicum annittin 1OO.O Guizotia abyssinica 32.5 Capsicum finitescens 66.6 Hamamelis virginiana 75.7 Capsicum finitescens 1OO.O Helianthus annuit is 69.0 Carthamus tinctorius 21.3 Heianthus Tiberosus 22.2 Carthamus tinctorius 21.5 Heianthus tuberosus 69.7 Chaerophyllum bulbosom 57.2 Heianthus Tiberosus 1OO.O Chelidonium maius 34.4 Hordeum hexastichon 22.3 Chenopodium bonus-henricus 43.5 Hordeum hexastichon 34.9 Chenopodium bonus-henricus 1OO.O Hordeum hexastichon 86.9 Chenopodium bonus-henricus 76.4 Hordeum vulgare 74.8 Chenopodium quinoa 92.0 Hordeum vulgare subsp. Vulgare 34.5 Chrysanthemum coronarium 48.6 Hordeum vulgare subsp. Vulgare 74.2 Chrysanthemum coronarium 49.7 Hyssopus officinalis 57.5 Chrysanthemum coronarium 47.3 Initia heienium 26.8 Chrysanthemum coronarium 26.7 Ipomoea Batatas 20.1 Cicer arietintin 22.O Lathyrus Saivais 28.7 Cicer arietintin 23.6 Lathyrus Saivais 1OO.O Cichorium intybus 21.1 Lathyrus Sylvestris 42.4 Cichorium intybus 1OO.O Lavandhiia iaiifolia 39.1 Citritius ianatus 65.5 Lepidium sativum 20.1 Citritius ianatus 96.3 Lepidium sativum 49.O Citritius ianatus 1OO.O Levisticum officinale 23.0 Coix Lacryma-Jobi 32.2 Levisticum officinale 29.8 Cornus Canadensis 52.8 Lintin itsitatissini in 56.9 Cosmos sulphureus 72.5 Lolium multiflorum 41.5 Crataegus spp 1OO.O Lolium multiflorum 92.3 Cryptotaenia Canadensis SO.6 Lotus corniculatus 95.5 Cryptotaenia Canadensis 51.3 Lotus tetragonolobits 76.7 Cuctimis anguria 53.4 Lycopersicon escientiin 35.3 Cuctimis Anguria 84.9 Lycopersicon escientiin 78.1 Cucumis meio 91.7 Lycopersicon escientiin 85.6 Cucurbita Maxina 34.9 Lycopersicon pimpinoliifolium 74.9 Cucurbita Maxina 41.7 Maiva moschata 21.5 Cucurbita moschata 36.8 Maiva moschata 445 Cucurbita moschata 37.4 Maiva verticiliata 22.0 Cucurbitapepo 48.1 Matricaria recitita 40.9 Cucurbitapepo 85.7 Matricaria recitita 67.3 Curcuna Zedoaria 21.O Melaleuca alternifolia 6S.O Curcuna Zedoaria 32.1 Meilotus aibus 50.7 Curcurbita maxima 27.0 Meilotus aibus 1OO.O Cymbopogon citratus 34.5 Melissa officinalis 42.4 Cymbopogon citratus 1OO.O Menthapulegitim 88.3 Cymbopogon martini 47.4 Mentha spicaia 94.8 Dactylis glomerata 20.6 Mentha suaveolens 82.9 Dactylis glomerata 75.O Nepeta Cataria 1OO.O Daiiciis Caroia 44.5 Nicotiana rustica 24.0 Daiiciis Caroia 70.5 Nicotiana rustica 1OO.O Dipsactis Saivais 40.4 Nicotiana tabacum 42.5 Dirca palustris 27.2 Nicotiana tabacum 61.1 Doichos Labiah 54.2 Nigella Saiiva 81.7 Dryopteris filix-mas 76.3 Ocimum tenuiflorum 23.1 Echinacea purpurea 42.9 Oenothera biennis 28.6 Eleusine coracana 37.5 Origantin majorana S2.9 Eleusine coracana 1OO.O Origantin majorana 1OO.O Erigeron Canadensis 45.7 Origantim vulgare 66.8 Erica vesicaria 80.2 Panax quinquefoils 31.8 Eschscholzia Californica 42.4 Pastinaca Saiiva 27.7 Eschscholzia Californica 75.O Pastinaca Saiiva 33.8 Eschscholzia Californica 88.8 Petasitesiaponicus 26.2 Fagopyrim esculenium 1OO.O Petroselinum crispum 69.1 Fagopyrim tariarictim 38.6 Phaiaris canariensis 28.4 Fagopyrim tariarictim 40.3 Phaiaris canariensis 29.7 Gainsoga ciliata S4O Phaiaris canariensis 94.3 Gaium odoratum 34.3 Phaseolus coccineus 30.8 Gaium odoratum 1OO.O Phaseolus coccineus 79.5 Gaultheria hispidula 35.8 Phaseolus coccineus 80.9 Gaultheria hispidula 1OO.O Phaseolus mingo 59.8 Giant x maritima 46.5 Phaseolus vulgaris 47.3 Glycine max 27.0 Phaseolus Vulgaris 744 US 2009/0263516 A1 Oct. 22, 2009 26

TABLE 2-continued TABLE 2-continued

MMP-2 MMP-2

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Phaseolus vulgaris A. R 83.2 Soianum melanocerastin A. O 88.7 Phaseolus Vulgaris A. O 1OO.O Soianum melongena A. S 42.5 Phlox paniculata A. O 23.7 Soianum melongena A. R 85.9 Phlox paniculata A. R 81.7 Sonchi is oleracetis A. R 25.6 Physalis alkekengi A. R 23.5 Sorghum cafiorum A. R 39.6 Physalis ixocarpa A. O 85.8 Sorghum dochna A. S 3O.O Physalis ixocarpa A. R 91.5 Sorghum dochna A. R 48.0 Physalis Pruinosa A. R 25.7 Sorghum dochna A. O 62.O Physalis Pruinosa A. O 83.5 Sorghum durra A. R 72.1 Phytolacca decandra A. O 31.5 Sorghum durra A. O 94.6 Phytolacca decandra A. S 38.5 Sorghum Sudanense A. O 1OO.O Pimpinella anisum A. S 1OO.O Spinacia oleracea A. S 23.6 Pimpinella anisum A. R 1OO.O Stachys affinis A. R 744 Plantago Coronopus A. R 36.0 Stachys byzantina A. R 48.4 Plantago Coronopus A. R 38.4 Stachys byzantina A. O 1OO.O Plantago Coronopus A. O S3.6 Stellariagraminea A. S 20.8 Plantago major A. R 65.3 Stellariagraminea A. R 37.5 Plectranthus sp. A. O 742 Steiaria media A. R 49.O Poa compressa A. S 37.3 Steiaria media A. S 50.7 Poa compressa A. R 49.8 Symphytum officinale A. R 44.2 Poa compressa A. O 1OO.O Tanacetum cinerariifolium A. R 1OO.O Polygontin pensylvanictim A. R 63.5 Tanacetain parthenium A. S 30.4 Polygontin pensylvanictim A. O 72.9 Tanacetum vulgare A. S 28.6 Polygontin persicaria A. S 27.5 Tanacetum vulgare A. R 1OO.O Polygontin persicaria A. O 43.0 Taraxacum officinale A. R 59.1 Poterium sanguisorba A. R 1OO.O Thymus praeco X subsp. arcticus A. R 43.5 Poterium Sanguisorba A. O 84.2 Thymus vulgaris A. S 30.1 Pteridium aquilinum A. O 45.1 Thymus X citriodorus A. R 1OO.O Pteridium aquilinum A. R 1OO.O Trichosanthes kirillowii A. S 29.2 Pysalis ixocarpa A. R 87.3 Trichosanthes kirillowii A. O 42.1 Raphantis raphanistrain A. S 32.2 Trigonelia foentingraecum A. O 53.4 Raphantis sativits A. R 25.3 Triticosecal spp. A. R 44.8 Raphantis sativits A. S 47.5 Trictim aestivum A. R 65.5 Raphantis sativits A. R 83.5 Triticum durum A. O 53.9 Raphantis sativits A. R 84.7 Triticum spelta A. R 26.4 Raphantis Saivais A. O 1OO.O Triticum spelta A. S 36.7 Rheum officinale A. O 44.0 Triticum spelta A. O S1.9 Ribes nigrum A. O 1OO.O Tropaeoluim maints A. R 25.8 Ribes nigrum A. R 1OO.O Urtica dioica A. O 22.9 Ricinits communis A. O 1OO.O Urtica dioica A. S 30.6 Rosa rugosa A. R 25.2 Vaccinium Corymbosum A. R 1OO.O Rosa rugosa A. S 26.6 Veratrum viride A. R 33.2 Rosa rugosa A. O 83.2 Verbascum thapsus A. S 22.9 Rosmarinus officinalis A. R 68.2 Veronica becoabunga A. R 52.8 Rubus idaeus A. O 81.9 Veronica officinalis A. R 84.2 Rubus idealis A. R 73.4 Vicia Saiva A. R 1OO.O Raine XAcetosa A. S 24.2 Vicia viliosa A. S 32.9 Raine XAcetosa A. R 85.5 Vicia viliosa A. R 1OO.O Raine XAcetosa A. O 1OO.O Vigna angularis A. R 54.0 Rumex crispiis A. O 46.7 Vigna sesquipedalis A. S 48.3 Rumex crispiis A. R 1OO.O Vigna sesquipedalis A. R 73.0 Rita graveolens A. O 1OO.O Vigna sesquipedalis A. O 96.6 Saccharum officinarum A. R 80.8 Vignatinguiculata A. R 70.7 Saixpirpurea A. S 56.7 Vinca minor A. S 22.1 Salvia officinalis A. S 24.1 Vinca minor A. R 88.4 Salvia officinalis A. O 91.8 Vitis sp. A. S 20.9 Saivia Sciarea A. O 99.7 Vitis sp. A. R 30.4 Santolina Chamaecyparissus A. O 83.8 Xanthium Sibiricum A. S 39.2 Satureia hortensis A. O 79.1 Xanthium Sibiricum A. R 47.8 Satureia hortensis A. R 1OO.O Xanthium Sibiricum A. O 70.1 Satureia montana A. R 60.4 Zea mayS A. R 1OO.O Satureia montana A. O 76.1 Zea Mays A. O 1OO.O Scorzonera hispanica A. S 22.1 Abelnochtis escientiis G S 21.6 Secale cereale A. R 47.2 Abelnochtis escientiis G R 79.3 Secale cereale A. O 67.2 Achillea millefolium G O 62.7 Senecio vulgaris A. S 23.2 Aconium napeiitis G O 82.O Senecio vulgaris A. R 76.6 Acorus calamus G S 1OO.O Sesamun indicum A. R 1OO.O Ageratum conyzoides G S 49.3 Sesamun indicum A. S 1OO.O Alcea rosea G R 64.4 Soianum duticamara A. R 54.5 Aichemia nois G S 21.5 Soianum melanocerastin A. S 45.4 Aichemia nois G R 30.2 Soianum melanocerastin A. R 85.2 Aichemia nois G O 55.7 US 2009/0263516 A1 Oct. 22, 2009 27

TABLE 2-continued TABLE 2-continued

MMP-2 MMP-2

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Allium ampeioprastin G O 36.1 Centatirea Solstitialis G S 46.4 Allium ampeioprastin G R 52.8 Cerastii in to mentostin G R 52.3 Allium ascalonictim G O 68.9 Chenopodium bonus-henricus G S 22.0 Allium cepa G S 40.2 Chenopodium quinoa G S 31.0 Allium cepa G R 66.4 Chenopodium quinoa G O 53.4 Allium cepa G O 1OO.O Chrysanthemun coronarium G R 76.2 Allium grande G R 36.4 Chrysanthemum coronarium G R 54.2 Aium sativum G S 29.5 Cicer arrieintin G S 23.1 Aium sativum G R 68.4 Cichorium endivia subspendivia G S 28.7 Aium sativum G O 1OO.O Cichorium endivia subspendivia G O 68.7 Allium Schoenoprastin G S 47.1 Cichorium intybus G S 41.4 Allium Schoenoprastin G R 61.7 Cichorium intybus G O 62.1 Aium tuberosum G S 23.8 Circium arvense G S 25.3 Aium tuberosum G O 54.5 Circium arvense G R 59.3 Aium tuberosum G R 85.9 Citritius ianatus G S 24.8 Aloe Vera G R S3.6 Citritius ianatus G R 41.1 Althaea officinalis G S 37.4 Citritius ianatus G R 1OO.O Altheaa officinalis G S 42.4 Cosmos Sulphureus G R 77.9 Amaranthus caudathus G S 30.9 Cosmos Sulphureus G S 79.4 Amaranthus caudathus G O 56.7 Ciclinissativits G S 39.9 Amaranthus gangeticits G S 23.1 Ciclinissativits G S 39.9 Anethtingraveolens G S 23.9 Cucurbita maxima G S 33.9 Angelica archangelica G S 22.O Cucurbita maxima G R 43.4 Angelica archangelica G S 24.9 Cucurbita maxima G O 1OO.O Apium graveolens G O 33.0 Cucurbita moschata G S 41.3 Apium graveolens G R 44.8 Cucurbitapepo G S 42.8 Apium graveolens G S 54.1 Cucurbitapepo G S 45.4 Apium graveolens G R 84.1 Cucurbitapepo G R 83.0 Aralia nudicatiis G R 51.8 Cuminum cyminum G O 66.2 Arctii in minus G S 25.4 Curcuna Zedoaria G R 33.9 Armoracia rusticana G O S2.1 Cymbopogon citratus G R 65.8 Aronia melanocarpa G S 22.5 Cymbopogon mariinii motia G S 41.4 Aronia melanocarpa G R 82.3 Cymbopogon mariinii motia G O 6O.S Artemisia dracunculus G R S3.6 Dactylis glomerata G S 21.9 Artemisia dracunculus G R 58.8 Dactylis glomerata G O 61.2 Artemisia dracunculus G S 1OO.O Daitira Stranonium G S 27.0 Artemisia dracunculus G O 1OO.O Daiiciis Caroia G O 21.3 Asclepias incarnata G S 26.9 Daiiciis Caroia G S 31.0 Asparagus officinalis G S 24.O Daiiciis Caroia G R 1OO.O Asparagus officinalis G R 65.9 Digitalis purpurea G S 30.9 Asparagus officinalis G O 95.0 Dipsactis sativus G O 63.6 Aster spp G O 48.4 Dirca palustris G O 23.1 Beckmannia eruciformis G O 24.8 Doichos Labiah G S 33.0 Bellis perennis G O S2.6 Dryopteris filix-mas G R 1OO.O Beta vulgaris G S 45.3 Echinacea purpurea G R 93.4 Beta vulgaris G R 1OO.O Eleusine Coracana G S 3O.O Beta vulgaris spp. Maritina G R 1OO.O Erigeron speciosus G S 28.9 Brassica cepticepa G R S2.9 Errhenaiherum eiatius G S 55.6 Brassica chinensis G R 41.9 Erica vesicaria G R 54.7 Brassica iuncea G R 22.8 Eschscholzia Californica G S 47.9 Brassica Naptis G S 22.9 Eschscholzia Californica G O 75.9 Brassica oleracea G R 45.5 Fagopyrim tariarictim G O 41.1 Brassica oleracea G R 47.1 Filipendula rubra G R 38.5 Brassica oleracea G S 62.9 Foeniculum vulgare G R 70.O Brassica oleracea G R 77.9 Foeniculum Vulgare G S 1OO.O Brassica oleracea G O 1OO.O Gainsoga ciliata G S 34.6 Brassica rapa G S 26.5 Gainsoga ciliata G R 48.2 Brassica rapa G R 38.9 Gaultheria hispidula G R 6O.S Brassica Rapa G R S3.6 Gaultheria hispidula G O 1OO.O Calamintha nepeta G S 20.4 Gaultheria hispidula G S 1OO.O Calamintha nepeta G O 78.O Giaux maritina G R 59.3 Cameia sinensis G O 1OO.O Glycine max G R 21.1 Campaniiia raptinctius G R 60.6 Glycine max G S 24.4 Canna eduis G O 78.1 Glycine max G O 28.1 Capsella bursa-pastoris G S 30.7 Guizotia abyssinica G S 26.0 Capsella bursa-pastoris G R 60.6 Guizotia abyssinica G R 36.8 Capsicum annittin G S 70.8 Guizotia abyssinica G O 1OO.O Capsicum annittin G O 80.0 Hedeona ptilegioides G O 94.6 Capsicum annittin G R 1OO.O Helianthus annuit is G S 35.5 Capsicum finitescens G S 63.2 Helianthus annuit is G O 75.0 Capsicum finitescens G R 1OO.O Helianthus annuit is G R 79.9 Carthamus tinctorius G R 1OO.O Heianthus strumosus G O 1OO.O US 2009/0263516 A1 Oct. 22, 2009 28

TABLE 2-continued TABLE 2-continued

MMP-2 MMP-2

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Heianthus tuberosus G R 642 Passiflora caerula G S 26.3 Helichrysum thianschanicum G O 61.1 Passiflora caerula G R 72.1 Helleborus niger G R 48.0 Pastinaca Saiiva G S 24.3 Hordeum hexastichon G S 26.8 Pastinaca Saiiva G R 90.2 Hordeum vulgare G O 65.4 Petroselinum crispum G R 87.6 Hordeum vulgare subsp. Vulgare G O 75.8 Petroselinum crispum G O 1OO.O Huntilus lupulus G S 26.O Phaiaris canariensis G R 1OO.O Hypericum hennyi G R 2O2 Phaiaris canariensis G O 1OO.O Hypericum hennyi G O 71.1 Phaseolus acutifolius G R 79.6 Hyssopus officinalis G O 1OO.O Phaseolus coccineus G S 28.3 Iberis amara G S 21.2 Phaseolus coccineus G R 80.4 Initia heienium G S 24.3 Phaseolus mingo G R 37.2 Lactica Saiiva G R 1OO.O Phaseolus vulgaris G R S4.3 Lactuca seriola G R 69.3 Phaseolus vulgaris G S 59.0 Laportea Canadensis G R 1OO.O Phaseolus vulgaris G O 73.7 Lathyrus Sylvestris G O 39.6 Phaseolus vulgaris G R 1OO.O Lavandhiia anguistifolia G O 70.O Phlox paniculata G R 37.7 Lavandhiia iaiifolia G S 22.7 Phlox paniculata G O 77.0 Lepidium Sativum G R 30.6 Phlox paniculata G R 80.8 Lepidium sativum G S 53.3 Physalis ixocarpa G S 3O.S Levisticum officinale G O 80.7 Physalis ixocarpa G R 78.3 Lolium multiflorum G O 34.5 Physalis ixocarpa G R 80.9 Lotus corniculatus G S 32.9 Physalis pruinosa G O 63.2 Lotus corniculatus G O 1OO.O Phytolacca americana G S 36.1 Lotus tetragonolobits G R 79.9 Phytolacca americana G O 1OO.O Lycopersicon escientiin G S 28.2 Pimpinella anisum G S 26.1 Lycopersicon escientiin G R 75.4 Pimpinella anisum G R 3O.O Lycopersicon pinpineliifolium G R 81.4 Pistin Saivain G S 28.4 Maius hupehensis G R 32.5 Plantago coronopus G R 27.8 Maius hupehensis G S 41.2 Plantago Coronopus G O S1.1 Maiva moschata G O 47.1 Plantago Coronopus G R 67.5 Malva Sylvestris G S 23.1 Plantago major G S 30.3 Maiva verticiliata G R 39.9 Plantago major G O 64.6 Matricaria recitita G O 3O.O Poa compressa G O 63.0 Matricaria recitita G S 71.3 Poa compressa G S 67.4 Melaleuca alternifolia G O 58.3 Poa compressa G R 89.0 Meilotus aiba G S 41.1 Poa pratensis G S 28.2 Meilotus aibus G O 88.8 Polygonum aviculare G R 1OO.O Meilotus aibus G R 1OO.O Polygontin pensylvanictim G S 27.7 Melissa officinalis G O 47.8 Polygontin pensylvanictim G O 54.1 Mentha arvensis G R 33.9 Polygontin persicaria G S 32.O Mentha arvensis G O 6.3.3 Polygontin persicaria G O 35.7 Mentha piperita G S 32.3 Polygontin persicaria G R 1OO.O Mentha piperita G O 85.9 Portuiaca oierracera G R 51.5 Mentha piperita G R 1OO.O Poterium sanguisorba G O 89.9 Mentha spicaia G S 28.9 Poterium sanguisorba G R 1OO.O Mentha spicaia G R 37.5 Poterium sanguisorba G S 23.7 Mentha suaveolens G R 25.6 Prunella vulgaris G S 26.7 Mentha suaveolens G O 70.3 Prunus cerasifera G R 95.3 Monoraica charania G R S2.9 Raphantis Raphanistrain G R 41.7 Monarda didyma G S 22.O Raphantis Raphanistrain G S 43.5 Monarda didyma G O 1OO.O Raphantis sativits G R 41.O Monarda fistulosa G O 26.O Raphantis sativits G S 44.6 Nepeta Cataria G S 23.4 Raphantis sativits G R 50.5 Nicotiana tabacum G S 45.2 Raphantis sativits G R 86.1 Nigella Saiiva G R 94.7 Raphantis sativits G O 1OO.O Ocimum basilicum G S 23.0 Reseda Odorata G O 58.3 Ocimum basilicum G O 1OO.O Rheum officinale G O 30.7 Ocimum tenuiflorum G R 45.3 Ribes nigrum G O S4.3 Oerothera biennis G R S4.3 Ribes nigrum G R 63.8 Origantin majorana G O 1OO.O Ribes Sylvestre G R 1OO.O Origantin majorana G R 1OO.O Ricinits communis G R 41.5 Origantim vulgare G R 93.3 Ricinits communis G O 1OO.O Origantim vulgare G O 93.5 Rosmarinus officinalis G R 90.0 Origantim vulgare G S 97.4 Rubus idaeus G S 37.1 Oxalis Deppei G S 28.7 Rubus idealis G R 26.6 Oxalis Deppei G R 87.2 Rubus occidenia is G R 35.1 Oxalis Deppei G O 1OO.O Rumex crispiis G R 30.3 Oxyria digyna G R 54.5 Rumex crispiis G S 1OO.O Panicum miliaceum G O 71.1 Rumex patientia G R 41.O Panicum miliaceum G R 1OO.O Rumex patientia G S 41.9 Panicum miliaceum G S 1OO.O Rita graveolens G S 47.9 US 2009/0263516 A1 Oct. 22, 2009 29

TABLE 2-continued TABLE 2-continued

MMP-2 MMP-2

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Rita graveolens G R 82.1 Tropaeoluim maints G S 21.3 Saccharum officinarum G R 1OO.O Tropaeoluim maints G R 45.6 Salvia elegens G O 1OO.O Urtica dioica G S 21.3 Salvia officinalis G S 35.3 Urtica dioica G O 1OO.O Salvia officinalis G O 1OO.O Valerianeia locusta G O 32.2 Salvia officinalis G R 1OO.O Veratrum viride G R 777 Sambucus ebulus G R 53.9 Verbascum thapsus G S 34.0 Santolina Chamaecyparissus G S 36.4 Veronica becoabunga G R 44.1 Santolina Chamaecyparissus G O 69.5 Veronica officinalis G S 38.8 Santolina Chamaecyparissus G R 1OO.O Veronica officinalis G R 87.5 Saponaria officinalis G S 29.8 Viburnum trilobum G O 62.6 Satureia hortensis G O 97.4 Vicia faba G S 22.2 Satureia hortensis G R 1OO.O Vicia Saiva G O 74.8 Satureia montana G O 59.2 Vicia Saiva G R 1OO.O Satureia repandra G S 35.3 Vicia viliosa G R 1OO.O Satureia repandra G O 66.2 Vigna angularis G R 65.2 Scorzonera hispanica G S 24.5 Vigna sesquipedalis G S 35.1 Scrophtiaria nodosa G S 24.5 Vigna sesquipedalis G R 73.8 Scrophtiaria nodosa G O 3O.O Vigna sesquipedalis G O 1OO.O Scrophtiaria nodosa G R 55.6 Vignatinguiculata G S 65.9 Scutellaria laterifiora G S 20.3 Vignatinguiculata G R 84.5 Scutellaria laterifiora G R 83.1 Vinca minor G S 22.1 Secale cereale G O S1.1 Vitis sp. G R 40.1 Senecio vulgaris G R 42.5 Vitis sp. G O 74.7 Sesamun indicum G S 34.3 Withania somnifera G S 37.3 Sesamun indicum G R 44.5 Withania somnifera G O 91.0 Silene vulgaris G S 34.1 Xanthium Sibiricum G S 38.4 Siim Sisartin G O 1OO.O Xanthium Sibiricum G O 1OO.O Soianum melanocerastin G S 40.6 Xanthium strumarium G S 37.7 Soianum melanocerastin G R 85.4 Xanthium strumarium G O 39.6 Soianum melongena G S 58.2 Xanthium strumarium G R 40.O Soianum melongena G O 83.0 Zea mayS G S 43.3 Soianum melongena G R 85.6 Zea mayS G O 64.4 Soianum tuberosum G O 40.2 Zea mayS G R 68.3 Sonchi is oleracetis G R 41.1 Abies lasiocarpa S 2O2 Sorghum dochna G S 2S.O Abies lasiocarpa R 59.1 Sorghum dochna G O 64.3 Achillea millefolium O 84.7 Sorghum dochna G R 1OO.O Aconium napeiitis O 22.0 Sorghum durra G R 60.1 Aconium napeiitis R 1OO.O Sorghum durra G O 1OO.O Adiantum pedatum R 1OO.O Sorghum Sudanense G O 98.0 Agarict is bisportis R S2.1 Spinacia oleracea G S 24.9 Agarict is bisportis R 65.6 Spinacia oleracea G O 1OO.O Ageratum conyzoides S 26.7 Stachys byzantina G R 78.8 Agropyron repens S 30.2 Stellaria graminea G S 29.3 Agrostis Stoionifera O 1OO.O Steiaria media G S 33.4 Alcea rosea R 63.7 Steiaria media G R 45.4 Aichemia nois R 28.6 Symphytum officinale G O 57.5 Allium ampeioprastin R 55.9 Tanacetum cinerariifolium G R 1OO.O Allium ampeioprastin O 60.4 Tanacetain parthenium G R 28.2 Allium ascalonictim S 20.4 Tanacetum vulgare G S 25.2 Allium ascalonictim O 73.4 Tanacetum vulgare G R 39.3 Allium cepa S 33.8 Tanacetum vulgare G O 81.2 Allium cepa S 35.6 Taraxacum officinale G R S1.1 Allium cepa R 48.0 Thymus fragantissinus G S 29.9 Allium cepa R 78.6 Thymus fragantissinus G O 55.3 Allium grande R 32.4 Thymus praeco X subsp. arcticus G S 27.7 Allium Schoenoprastin R 67.7 Thymus serpyllum G R 74.9 Aium tuberosum S 38.8 Thymus vulgaris G S 23.3 Aium tuberosum O 82.5 Thymus vulgaris G R 86.4 Aium tuberosum R 85.2 Thymus X citriodorus G R 97.6 Aloe vera R 74.6 Tragopogon porrifolius G R 76.2 Althaea officiana is S 37.7 Trichosanthes kirillowii G O 87.7 Althaea officinalis O 55.3 Trigonelia foentingraecum G S 31.0 Althaea officinalis R 72.3 Trigonelia foentingraecum G O 84.O Amaranthus caudathus O 53.5 Triticosecale spp G S 26.5 Amaranthus gangeticits S 28.1 Triticosecale spp G O 73.5 Ananas Conostis R 37.9 Trictim aestivum G R 62.4 Ananas Conostis O 1OO.O Triticum durum G O S1.9 angelica archangelica R 41.3 Triticum spelta G S 24.5 Anthemis nobiis O 1OO.O Triticum spelta G O 32.9 Anthemis nobiis R 1OO.O Triticum turgidium G O 25.1 Anthriscus cerefolium S 21.9

US 2009/0263516 A1 Oct. 22, 2009 31

TABLE 2-continued TABLE 2-continued

MMP-2 MMP-2

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Heliotropium arborescens R 1OO.O Nigella Saiiva R 90.3 Helleborus niger R 23.0 Nigella Saiiva R 1OO.O Hibiscus cannabinus R 37.9 Ocimum Basilicum S 21.6 Hordeum vulgare O 75.9 Ocimum Basilicum O 1OO.O Hordeum vulgare supsp vulgare S 2O.S Ocimum tenuiflorum R 445 Hordeum vulgare supsp vulgare O 62.3 Oenothera biennis R 48.2 Huntilus lupulus S 44.7 Onobrychis viciifolia S 34.4 Huntilus lupulus O 70.6 Onobrychis viciifolia O 35.6 Hypericum hennyi O 76.8 Opiiniia sp. S 23.5 Hypericum hennyi R 99.8 Origantim vulgare S 20.7 Hyperictim perforatin R 38.8 Origantim vulgare R 76.7 Hyssopus officinalis O 1OO.O Origantim vulgare O 1OO.O Iberis amara O 1OO.O Oryza sativa R 60.8 Juniperus communis S 1OO.O Oxalis Deppei S 22.2 Kochia Scoparia S 25.2 Oxalis Deppei R 81.4 Koeleria giatica S 23.1 Passiflora caerulea S 36.9 Lactica Saiiva R 70.5 Passiflora caerulea R 87.O Lactuca seriola R 34.1 Passiflora spp R 54.6 Laportea Canadensis R 61.3 Pastinaca Saiiva S 24.8 Lathyrus Sylvestris R 48.6 Pastinaca Saiiva R 74.7 Latiri is nobilis O 73.6 Perilla frutescens R 1OO.O Lavandhiia anguistifolia R 3S.O Perroselinum crispum R 85.2 Lavandhiia anguistifolia O 1OO.O Perroselinum crispum O 1OO.O Lavandhiia iaiifolia O 77.1 Persea americana R 43.1 Lepidium sativum S 35.2 Petasites Japonicus S 21.9 Lepidium sativum R 48.1 Petroselinum crispum R 52.8 Lepidium sativum O 72.9 Peucedanum of easeinum R 41.9 Levisticum officinale S 38.7 Phaiaris canariensis R 41.1 Levisticum officinale O 60.3 Phaiaris canariensis O 1OO.O Lintin itsitatissini in R 24.7 Phaseolus acutifolius R 88.2 Lolium multiflorum S 39.8 Phaseolus coccineus S 22.2 Lolium multiflorum O 74.1 Phaseolus coccineus R 36.4 Lonicera ranosissina S 34.4 Phaseolus coccineus R 86.7 Lonicera ranosissina O 8O.S Phaseolus coccineus O 1OO.O Lonicera syringantha R 58.4 Phaseolus mingo S 43.O Lotus corniculatus S 36.0 Phaseolus vulgaris S 62.9 Lotus corniculatus O 1OO.O Phaseolus vulgaris R 71.9 Lotus tetragonolobits R 76.1 Phaseolus vulgaris R 73.0 Linaria annia R 47.4 Phaseolus vulgaris O 1OO.O Lycopersicon escientiin R 69.7 Phlox paniculata R 23.1 Lycopersicon pinpineliifolium R 58.7 Phlox paniculata R 92.8 Maius hupehensis R 53.1 Physalis alkekengi R 39.5 Maius hupehensis S 1OO.O Physalis ixocarpa R 36.7 Maius sp. R 72.6 Physalis ixocarpa R 75.9 Maiva moschata O 96.7 Physalis pruinosa R 65.6 Maiva verticiliata R 35.8 Physalis pruinosa R 71.O Manihot escuienia R 53.7 Physalis pruinosa O 1OO.O Melaleuca alternifolia S 21.5 Physalis pruinosa O 1OO.O Melaleuca alternifolia O 78.7 Phytolacca decandra S 39.3 Meilotus aibus R 79.7 Phytolacca decandra O 42.O Melilotus officinalis S 34.6 Pimpinella anisum S 27.9 Melilotus officinalis R 1OO.O Pimpinella anisum R 35.8 Melissa officinalis O 1OO.O Pimpinella anisum O 49.9 Mentha piperita S 24.5 Pimpinella anisum R 55.5 Menthapulegitim O 1OO.O Pistin Saivain S 22.3 Mentha suaveolens O 20.9 Plantago Coronopus R 35.2 Miscanthus sinensis Andress S 69.1 Plantago Coronopus R 46.0 Monoraica charania R S4.9 Plantago Coronopus O 73.5 Monarda didyma S 31.3 Plantago major S 22.3 Monarda fistulosa S 21.3 Plectranthus sp. S 59.2 Monarda fistulosa O 1OO.O Pleurotus spp R 26.6 Montia perfoliata R 67.2 Poa compressa S 33.4 Musa paradisiaca R 47.3 Poa compressa R 75.7 nastairtium officinale S 55.7 Poa compressa O 1OO.O Nepeta Cataria S 20.7 Poa pratensis S 25.4 Nepeta Cataria S 69.0 Polygontin pensylvanictim O 66.8 Nepeta Cataria O 1OO.O Polygontin pensylvanictim R 73.3 Nicotiana rustica S 52.8 Polygontin persicaria S 27.1 Nicotiana rustica R 88.1 Polygontin persicaria O SO.8 Nicotiana tabacum S S.O.3 Populus incrassata O 74.3 Nicotiana tabacum R 91.5 Populus incrassata S 1OO.O Nigella Saiiva R 34.2 Prints armeniaca R 55.0

US 2009/0263516 A1 Oct. 22, 2009 33

TABLE 2-continued TABLE 3-continued

MMP-2 MMP-3

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Xanthium Sibiricum 33.2 Fragaria Xananassa 99.6 Xanthium Sibiricum 62.4 Fragaria Xananassa 31.7 Xanthium strumarium 47.2 Gaultheria hispidula 50.5 Glycyrrhiza glabra 56.2 Xanthium strumarium 74.3 Hedeona ptilegioides 51.7 Zea mays 55.7 Heianthus tuberosus 22.9 Zea mays 1OO.O Hordeum vulgare subsp. vulgare 36.0 Zingiber officinale 79.0 Hypericum hennyi 67.2 Hyperictim perforatin 31.7 Hyssopus officinalis 21.6 Iris versicolor S3.6 TABLE 3 Isais inctoria 32.9 Levisticum officinale 46.7 MMP-3 Lotus tetragonolobits 26.2 Matricaria recitita 43.5 Nom latin Stress Extrait Inhibition (%) Matteucia pensylvanica 24.7 Melissa officinalis 30.3 Achillea millefolium 21.4 Mentha suaveolens 91.7 Aium Tuberosum 32.5 Nepeta Cataria 30.3 Anethtingraveolens 26.O Nigella Saiiva 26.0 Anthemis nobilis 20.3 Ocinum tenuiflorum 33.0 Anthemistinctoria 58.0 Ocinum tenuiflorum 49.8 Apium graveolens 34.1 Perilla frutescens 34.8 Arctii in minus 53.9 Petasitesiaponicus 38.0 Arctii in minus 1OO.O Phaseolus mingo 62.6 Arctostaphylos tiva-lisi 58.6 Phaseolus vulgaris 21.2 Aronia melanocarpa 32.2 Phaseolus vulgaris SO.6 Artemisia Absinthium 1OO.O Phaseolus Vulgaris 1OO.O Artemisia dracunculus 23.4 Phlox paniculata 46.4 Artemisia dracunculus 63.0 Physalis alkekengi 37.5 Aster sp 42.4 Plantago major 27.3 Atropa belladonna 23.8 Polygonum aviculare linné 24.8 Beta vulgaris 24.1 Polygontin persicaria 59.1 Beta vulgaris 42.9 Potentiiia anserina 40.1 Beta vulgaris 94.3 Poterium sanguisorba 75.7 Beta vulgaris 97.9 Prints cerasitera 80.0 Beta vulgaris var. condiivata 21.2 Piaridium aquilinus 39.6 Brassica naptis 2S.O Raphantis raphanistrain 28.2 Brassica naptis 1OO.O Raphantis sativits 64.4 Brassica oleracea 39.9 Ribes nigrum 47.6 Canna eduis 39.6 ribes tiva-crispa 21.0 Capsicum annittin 35.4 ribes tiva-crispa 1OO.O Capsicum finitescens 27.2 Rosa rugosa 21.4 Cichorium intybus 2O2 Rosmarinus officinalis 27.3 Cichorium intybus 26.5 Rubus allegheniensis 81.0 Cichorium intybus 28.2 Rubus arcticus S1.0 Citritius ianatus 21.7 Rubus Canadensis 48.8 Citritius ianatus 27.8 Rubus idaeus 28.5 Citritius ianatus 34.4 Rubus idaeus 35.1 Coix Lacryma-Jobi 37.3 Rubits pubescens SO.4 Coix Lacryma-Jobi 78.1 Rubus thibetanus 39.1 Cosmos sulphureus 26.8 Rumex patientia 24.8 Crataegus Suibnois 22.3 Rita graveolens 56.1 Crataegus Suibnois 61.6 Salvia officinalis 43.2 Cuctimis anguria 27.8 Santolina Chamaecyparissils 27.0 Cucurbita Maxina 28.9 Scutellaria laterifiora 53.5 Cucurbita moschata 32.9 Soianum melongena 21.8 Cucurbitapepo SO.9 Solidago Canadensis 27.4 Datisca cannabina 43.3 Stachys affinis 1OO.O Datisca cannabina 1OO.O Steiaria media 24.4 Digitalis purpurea 2O.O Tanacetum vulgare 62.1 Dipsactis Saivais 64.8 Thymus praecox. Subsp. arcticus 28.4 Dirca palustris 29.6 Thymus praecox. Subsp. arcticus 31.8 Dryopteris filix-mas 22.O Trichosanthes kirillowii 23.2 Dryopteris filix-mas 32.8 Vaccinium Corymbosum 1OO.O Echinacea purpurea 1OO.O Vaccinium macrocarpon 48.6 Fagopyrim tatarictim 28.3 Vaccinium augustifolium 56.6 Fagopyrim tatarictim 29.7 Vigna angularia 23.1 Filipendula rubra 43.7 Vigna sesquipedalis 37.8 Filipendula rubra 63.2 Vignatinguiculata 52.5 Fragaria Xananassa 41.5 Vinca minor 23.2 Fragaria Xananassa 67.1 Vitis sp. 20.8 US 2009/0263516 A1 Oct. 22, 2009 34

TABLE 3-continued TABLE 3-continued

MMP-3 MMP-3 Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Vitis sp. A. O 21.5 Melissa officinalis G S 32.8 Vitis sp. A. R 33.6 Melissa officinalis G R 44.8 Xanthium Sibiricum A. S 27.3 Melissa officinalis G O 82.4 Aconium napelius G O 59.0 Mentha piperita G R 77.3 Agropyron repens G O 69.4 Menthapulegitim G R 41.1 Aichemia nois G S 30.6 Monarda didyma G S 31.8 Aichemia nois G O 73.3 Nepeta Cataria G R 25.8 Allium grande G O 33.4 Nepeta Cataria G O 84.9 Anethtingraveolens G S 40.5 Nigella Saiiva G O 44.9 Aronia melanocarpa G O 1OO.O Ocinum tenuiflorum G R 23.7 Artemisia absinthium G S 31.3 Oenothera biennis G S 25.6 Artemisia absinthium G O 67.9 Origantim vulgare G S 28.6 Artemisia dracunculus G S 1OO.O Origantim vulgare G R 31.2 Atropa belladonna G S 41.2 Pennisetum alopectiroides G S 49.9 Bellis perennis G S 48.4 Petroselinum crispum G S 31.5 Brassica oleracea G S 26.4 Peucedanum of easeinum G R 68.3 Brassica oleracea G O 40.6 Phaseolus acutifolius G R 25.4 Brassica rapa G S 21.4 Phaseolus acutifolius G O 618 Capsicum annittin G S 3S.O Phaseolus vulgaris G O 24.4 Capsicum annittin G S 35.7 Phaseolus vulgaris G S 35.6 Capsicum finitescens G S 27.5 Phlox paniculata G S 27.2 Chelidonium maius G O 34.7 Physalis alkekengi G R 26.1 Cichorium intybus G R 34.4 Physalis alkekengi G O S4.9 Coix Lacryma-Jobi G S 2O2 Plantago major G O 55.9 Cosmos sulphureus G O 32.9 Plectranthus sp. G R 23.0 Crataegus Suibnois G S 25.6 Polygontin persicaria G S 41.1 Crataegus Suibnois G R 28.6 Potentiiia anserina G R SS.4 Cuctimis anguria G S 33.6 Poterium sanguisorba G R 76.4 Cucurbita maxima G S 44.6 Prunus cerasifera G R 55.3 Cucurbita moschata G S 33.4 Piaridium aquilinus G R 445 Cucurbitapepo G S 25.3 Rhaphanaissativits G O 98.1 Cymbopogon citratus G S 30.3 Rheum x cuitorum G R 27.0 Cymbopogon martini G S 61.1 Ribes nidigrolaria G R 22.0 Daiiciis Caroia G O 3O.O Ribes Silvestris G R 88.8 Dryopteris filix-mas G S 26.O Rosmarinus officinalis G R 39.4 Dryopteris filix-mas G R 45.3 Rubus idaeus G S 1OO.O Echinacea purpurea G O 51.8 Rubus idealis G O 37.0 Echinochloa frumentacea G S 30.3 Rubus Phoenicaiasius G R 24.9 Fagopyrim esculenium G R SO.9 Rubits pubescens G O 23.0 Fagopyrim tariarictim G O 44.0 Rubus thibetanus G O 41.2 Fagopyrim tariarictim G R 46.0 Rumex patientia G S 36.2 Filipendula rubra G S 53.1 Salvia officinalis G O 34.5 Filipendula rubra G R 58.7 Salvia officinalis G R 89.5 Forsythia intermedia G O S2.9 Sanguisorba officinalis G S 46.8 Fragaria Xananassa G R 40.7 Santolina Chamaecyparissils G R 33.7 Fragaria Xananassa G R 28.1 Secale cereale G S 24.4 Gaultheria hispidula G R 72.8 Senecio vulgaris G R 37.6 Gaultheria hispidula G O 1OO.O Soianum melongena G S 21.1 Gaultheria procumbens G R 24.1 Soianum tuberosum G S 27.6 Glycine max G S 31.2 Sorghum dochna G S 23.7 Glycyrrhiza glabra G R 37.1 Sorghum dochna G R 56.3 Guizotia abyssinica G R 35.4 Symphytum officinale G S 25.2 Hamamelis virginiana G S 29.1 Teucrium chamaedrys G S 75.4 Hamamelis virginiana G R 67.1 Thymus praecox. Subsp. arcticus G S 28.4 Helenium hoopesii G R 39.8 Thymus praecox. Subsp. arcticus G O S2.1 Heianthus tuberosus G O 32.8 Thymus X citriodorus G R 25.3 Hordeum hexastichon G S 60.9 Triticum durum G S 21.9 Huntilus lupulus G R 61.2 Triticum turgidium G O 80.2 Huntilus lupulus G S 90.5 Vaccinium anglisiifolium G R 47.6 Hypericum hennyi G R 1OO.O Vaccinium anglisiifolium G R 48.1 Hyperictim perforatin G R 43.4 Vaccinium anglisiifolium G R 71.O Hyssopus officinalis G S 25.1 Vaccinium corymbosum G R 60.6 Hyssopus officinalis G O 48.2 Vaccinium corymbosum G R 61.7 Iris versicolor G R 47.0 Vaccinium corymbosum G O 99.4 Isa is tinctoria G S 32.1 Vaccinium macrocarpon G R 1OO.O Lavandhiia anguistifolia G S 43.9 Vaccini in anglisiifolium G O 24.4 Levisticum officinale G O 51.4 Vaccini in anglisiifolium G R 41.5 Maius hupehensis G S 24.2 Valeriana officinalis G R 33.5 Maius hupehensis G R 37.2 Veronica officinalis G S 27.0 Malva Sylvestris G O 73.7 Vicia faba G O 31.2 Matricaria recitita G S 31.5 Vicia faba G R 44.7 Melaleuca alternifolia G S 21.5 Vigna angularia G O 40.8 US 2009/0263516 A1 Oct. 22, 2009 35

TABLE 3-continued TABLE 3-continued

MMP-3 MMP-3 Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Vigna angularis G S 39.4 Curcuna Zedoaria S 20.8 Vignatinguiculata G O 26.1 Cymbopogon citratus S 39.7 Vitis sp. G R 62.4 Doichus iabiah S 25.8 Vitis sp. G S 6.3.3 Dryopteris filix-mas O 54.0 Vitis sp. G O 82.O Echinacea purpurea S 20.4 Withania somnifera G S 22.4 Eriobotrya japonica O 34.8 Xanthium strumarium G S 20.7 Eriobotrya japonica S 42.9 Zea mays G S 26.1 Foericulum vulgare O 33.1 Zea mays G R 67.5 Fragaria Xananassa S 20.3 Abies lasiocarpa R 46.2 Fragaria Xananassa R 42.8 Acorus calamus R 21.8 Glycine max O 26.3 Actinidia argutta R 64.6 Glycine max O 3O.S Agropyron repens O 48.3 Gossypium herbaceum R 22.5 Aichemia nois R 1OO.O Guizotia abyssinica R 46.6 Aichemia nois O 1OO.O Hamamelis virginiana S 33.1 Allium cepa R 39.8 Hamamelis virginiana S 33.1 Allium cepa O 45.2 Hamamelis virginiana R 44.8 Aium tuberosum R 28.2 Hedeona ptilegiodes O 46.8 Aium tuberosum S 28.8 Helenium hoopesii R 27.9 Alpinia officinarum S 26.4 Heianthus annus S 22.7 Amelianchierainitoia R 78.3 Heianthus strumosus O 3O.O Amelanchier sanguinea XA. laevis R 66.5 Heliotropium arborescens O 53.7 angelica archangelica S 25.2 Helleborus niger S 4O.S Apium graveolens R 43.3 Hibiscus cannabinus O 34.0 Aralia Cordata S 31.5 Hordeum vulgare subsp. Vulgare O 1OO.O Aralia nudicatiis S 37.7 Huntilus lupulus S 24.9 Aralia nudicatiis R 48.5 Huntilus lupulus R 55.1 Aronia melanocarpa S 26.O Huntilus lupulus R 77.6 Aronia melanocarpa O 53.3 Humulus lupulus S 79.1 Aronia prunifolia R 79.2 Huntilus lupulus S 1OO.O Artemisia absinthium O 1OO.O Huntilus lupulus R 1OO.O Artemisia drachinius S 42.O Huntilus lupulus S 1OO.O Apertis escientiis O 67.8 Hypericum hennyl R 1OO.O Beta vulgaris R 27.9 Hyperictim perforatin O 99.3 Beta vulgaris S 33.2 Hypomyces lactiflorum O 2O.S Beta vulgaris O 53.0 Iris versicolor R 48.5 Borago officinalis O 55.7 Juniperus communis R 33.8 Brassica Naptis O 71.9 Lactuca seriola R 21.5 Brassica oleracea O 37.0 Laportea Canadensis S 37.7 Brassica oleracea S 46.9 Lavendula angustifolia S 91.7 Brassica rapa S 36.7 Lepidium sativum R 24.7 Bronts inermis R 42.8 Levisticum officinale O 24.9 Calendula officinalis L. S 28.4 Lolium perenne S 22.3 Cameliia Sinensis syn. Thea Sinensis R 86.4 Lonicera ranosissina R 42.5 Capsicum annis S 29.7 Lonicera syringantha R 21.1 Capsicum annis R 43.7 Maius O 53.1 Capsicum finitescens (tabasco) S 22.O Maius hupehensis (Pamp.) Rehd. R 76.5 Carya cordiformis R 27.5 Maius sp. R 39.8 Chaerophyllum bulbosum S 27.1 Maius sp. R 45.7 Chaerophyllum bulbosum O 1OO.O Maiva moschata S 22.8 Chelidonium maius O S4O Malva Sylvestris O 57.6 Chrysanthemum parthenium S SO.4 Matteucia pensylvanica R 20.1 Chrysanthemum coronarium S 25.8 Melissa officinalis O 55.0 Cichorium inlybus R 23.9 Mentha piperita R 35.5 Citritius ianatus S 33.2 Mentha piperita O 43.9 Citrulius lanatus (Garden baby) S 21.4 Mentha piperita R 56.6 Citrus innettoides O 39.2 Menthapulegitim O 33.3 Citrus innon O 60.4 Menthapulegitim R 56.2 Corchorus oitorius S 28.6 Mentha spicaia O 43.4 Cornus Canadensis L. O SO.O Mentha spicaia O 58.0 Cornus Canadensis L. R 80.6 Nicotiana tabacum R 27.3 Cosmos sulphureus R 2O.S Nigella Saiiva R 25.1 Cosmos sulphureus S 27.0 Ocimum Basilicum R 2O2 Crataegus sp S 43.9 Ocnothera biennis S 37.8 Crataegus Suibnois O 24.2 Origantin nationara R 45.2 Crataegus Suibnois R 55.1 Origantim vulgare S 21.3 Cuctimis anguria S 33.2 Origantim vulgare O 23.3 Cucumissativus Fanfare S 35.4 Origantim vulgare R 23.6 Cucurbita moschata S 30.4 Origantim vulgare O 37.2 Cucurbitapepo R 23.8 Panicum miliaceum S 20.6 Cucurbitapepo S 46.6 Panicum miliaceum S 30.7 Cuminum cyminum S 23.1 Pastinaca Saiva R 26.1 US 2009/0263516 A1 Oct. 22, 2009 36

TABLE 3-continued TABLE 3-continued

MMP-3 MMP-3 Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Pastinaca Saiiva O 1OO.O Vaccinium anglisiifolium R 28.0 Peucedanum of easeinum S 39.6 Vaccinium anglisiifolium S 29.6 Peucedanum of easeinum R 53.4 Vaccinium anglisiifolium R 33.3 Phaseolus vulgaris S 21.8 Vaccinium anglisiifolium Ait. R 1OO.O Phaseolus vulgaris O 23.6 Vaccinium macrocarpon S 25.1 Phaseolus vulgaris O 59.8 Vaccinium macrocarpon R 27.4 Physalis alkekengi O 55.5 Vaccinium macrocarpon O 35.4 Physalis pruinosa S 24.8 Vaccinium macrocarpon R 8O.S Plantago major O 77.1 Vaccinium macrocarpon O 9 O.S Poa compressa R 54.4 Valeriana officinalis O 33.0 Polygonium chinense O 36.3 Veratrum viride S 46.8 Polygonium chinense R 61.4 Verbascum thapsus O 33.4 Polygontin persicaria S 21.3 Vicia faba R 26.6 Populus incrassata S 50.7 Vicia faba O 35.8 Populus incrassata S 50.7 Vigna angularia S 29.3 Popitius Xpetrowskyana R 66.7 Vigna angularia O 54.0 Prunus cerasifera O 26.1 Vigna sesquipedalis O 1OO.O Prunus cerasifera R 642 Vignatinguiculata S 49.5 Psidium guajaba T S 22.9 Vitia sp. O 99.6 Piaridium aquilinus R 43.0 Vitis sp R SO.9 Pyrus pyrifolia S 28.2 Vitis sp. R 75.8 Rahmni is fianguia R 25.9 Raphantis sativits R 21.4 Weigela coracensis S 22.8 Raphantisp sativits O 36.9 Weigela coracensis S 22.8 Rhamnus fianguia O 43.2 Weigela hortensis R S4.9 Rheum rhabarbarium O 28.5 Zea mayS O 74.3 Rheum Xcuitorum R 28.2 Rianits communis S 32.4 Ribes nidigrolaria S 28.5 Ribes nigrum R 49.9 TABLE 4 Rosa rugosa S 29.1 Rosmarinum officinalis R 48.2 MMP-9 Rubus arcticus R 59.1 Rubus idealis O 21.5 Inhibition Rubits pubescens O 51.8 Nomlatin Stress Extrait (%) Rubus thibetanus O 33.7 Rumex patientia S 34.4 Abelnochtis escientiis A. S 26.8 Rita graveolens O 24.3 Achillea millefolium A. S 41.6 Salvia (elegens) O 37.2 Aconium napeiitis A. O 47.7 Salvia (elegens) R 42.9 Acorus calamus A. O 83.2 Salvia officinalis R 67.3 Actinidia argutta A. S 26.8 Sambucus Canadensis S 30.2 Adiantum pedatum A. O 20.7 Sanguisorba minor R 21.O Agastache foeniculum A. S 1OO.O Sanguisorba minor R 29.9 Agrimonia eupatoria A. W 21.4 Sanguisorba minor R 30.8 Agropyron cristatum A. R 51.4 Sanguisorba minor R 44.5 Agropyron repens A. S 27.3 Santoina R 43.8 Agrostis alba A. R 40.6 Sarratuia tinctoria S 37.7 Agrostis Stofonifera A. R 35.4 Satureia montana R 45.0 Alcea rosea A. S 45.8 Satureia repandra S 46.3 Aikanna tinctoria A. S 42.5 Scorzorera hipanica R 25.7 Allium cepa A. O 49.7 Scuttellaria laterifiora S 41.2 Allium grande A. R 71.4 Setaria itaica S 33.4 Allium porrum A. S 28.0 Solidago Canadensis S 78.5 Allium porrum A. O 82.O Stachys affinis S 1OO.O Aium sativum A. S 23.7 Stachys byzantina O 1OO.O Allium Schoenoprastin A. O 45.5 Stellaria media (linné) Cyrillo O 51.2 Aium tuberosum A. V 20.1 Tanacetum vulgare R 3O.S Aium Tuberosum A. O 91.5 Teparty R 31.7 Althaea officinalis A. S 29.6 Teparty O 39.7 Amaranthus gangeticits A. O 25.1 Thymus serpyllum O 29.9 Amaranthus gangeticits A. R 31.1 Thymus serpyllum R 32.8 Amaranthus gangeticits A. S 73.2 Thymus X citriodorus S 22.1 Amaranthus retroflexus A. S 20.4 Tiarella cordifolia R 46.8 Ambrosia artemisiifolia A. R SO.1 Tragopogon porrifolium R 26.3 Amelanchier sanguinea A. W 37.6 Tragopogon porrifolium R 29.8 Anthemis nobiis A. O 40.4 Tragopogon porrifolium O 58.0 Anthemis nobiis A. R 66.7 Triticale sp. O 25.3 Anthemistinctorium A. S 30.3 Tropaeoluim maints O 46.9 Apium graveolens A. R 71.2 Tropaeoluim maints O 55.8 Arachis hypogaea A. V 23.5 Tropaeoluim maints R 64.7 Aralia Cordata A. S 21.2 Tsuga Candadensis R 39.2 Aralia Cordata A. S 56.3 US 2009/0263516 A1 Oct. 22, 2009 37

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Arctii in minus 31.1 Crataegus sp 32.4 Arctostaphylos tiva-lisi 31.2 Crataegus sp 45.5 Arctostaphylos tiva-lisi 31.2 Crataegus sp 1OO.O Arctostaphylos tiva-lisi 59.7 Crataegus Suibnois 45.5 Armoracia rusticana 25.1 Cryptotaenia Canadensis 26.4 Armoracia rusticana 56.2 Clictimis Anguria 27.2 Aronia melanocarpa 26.8 Clictimis anguria 36.6 Aronia melanocarpa 41.3 Clictimis anguria 38.5 Aronia melanocarpa 44.8 Cucumis meio 59.2 Aronia melanocarpa 47.7 Ciclinissativits 39.8 Aronia melanocarpa 55.7 Ciclinissativits 49.4 Aronia melanocarpa 1OO.O Ciclinissativits 54.4 Arrhenaiherineiatius 40.4 Cucurbita Maxina 46.7 Artemisia dracunculus S1.1 Cucurbita moschata 32.1 Asparagus officinalis 20.9 Cucurbitapepo 37.0 Asparagus officinalis 32.6 Curburbita pepo 410 Aster sp 29.5 Curburbita pepo 43.9 Aster sp 80.0 Curcuna Zedoaria 67.6 Atropa belladonna 47.4 Curcurbita maxima 25.8 Beta vulgaris 25.3 Cymbopogon citratus 26.7 Beta vulgaris 26.6 Dactylis glomerata 27.2 Beta vulgaris 34.O Datisca cannabina 26.9 Beta vulgaris 42.O Datisca cannabina 38.0 Beta vulgaris 44.0 Daiiciis Caroia 30.8 Beta vulgaris spp. Maritina 44.0 Daiiciis Caroia 31.9 Beta vulgaris var. condiivata 35.4 Dirca palustris 27.3 Brassica naptis 24.6 Dirca palustris 34.2 Brassica napus 53.1 Doicos Labiah 22.O Brassica naptis 1OO.O Doicos Labiah 25.3 Brassica nigra 24.2 Dryopteris filix-mas 24.9 Brassica oleracea 33.0 Dryopteris filix-mas 40.6 Brassica oleracea 36.0 Eleusine Coracana 2O2 Brassica oleracea 36.2 Eleusine Coracana 20.9 Brassica oleracea 73.1 Eleusine Coracana 71.1 Brassica Oieracea 1OO.O Elymaisincetts 45.4 Brassica rapa 31.0 Erigeron Canadensis 35.7 Brassica rapa 38.6 Erica vesicaria 59.9 Brassica rapa 42.8 Fagopyrim esculenium 20.7 Brassica rapa 48.8 Fagopyrim tariarictim 30.3 Brassica rapa 68.2 Fagopyrim tariarictim 33.2 Brassica rapa 89.2 Festuca rubra 31.8 Bronts inermis 51.4 Foeniculum Vulgare 27.4 Campaniiia raptinctius 25.1 Foeniculum vulgare SO.6 Canna eduis 31.1 Forsythia intermedia 1OO.O Canna eduis 47.6 Fragaria Xananassa 3O.O Canna eduis 68.9 Fragaria Xananassa 36.3 Capsella bursa-pastoris 32.5 Gaium odoratum 26.9 Capsicum annittin 22.O Gaultheria hispidula 28.4 Capsicum annittin 24.O Gaultheria hispidula 40.7 capsicum annittin 55.7 Gentiana lutea 34.7 Capsicum finitescens 30.3 Giechona hederacea 37.6 Capsicum finitescens 34.7 Glycine max 38.1 Carthamus tinctorius 28.5 Glycine Max 56.4 Cartin carvi 38.6 Glycine max 71.4 Chelidonium maius 27.9 Glycyrrhiza glabra 62.6 Chenopodium bonus-henricus 47.4 Glycyrrhiza glabra 1OO.O Chenopodium bonus-henricus 20.7 Guizotia abyssinica 91.9 Chenopodium bonus-henricus 23.2 Hamamelis virginiana 410 Chenopodium bonus-henrict is 62.8 Hamamelis virginiana 74.6 Chenopodium quinoa 23.1 Hedeona ptilegioides 22.O Chenopodium quinoa 34.7 Heianthus tuberosus 21.2 Chrysanthemum leucanthemum 20.6 Heianthus tuberosus 51.5 Chrysanthemum leucanthemum 30.9 Helichrysum angustifolium 21.O Chrysanthemun coronarium (Chip Suey) 26.4 Heliotropium arborescens 54.1 Chrysanthemum coronarium 66.6 Helleborus niger 37.8 Cichorium intybus 44.7 Hordeum hexastichon 38.0 Citritius ianatus 62.1 Hyssopus officinalis 25.1 Citritius ianatus 70.6 Initia heienium 29.7 Cornus Canadensis 48.5 Isais inctoria 41.5 Cosmos sulphureus 23.4 Lactuca seria 41.3 Cosmos sulphureus 37.0 Lactuca seriola 46.6 US 2009/0263516 A1 Oct. 22, 2009 38

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Laportea Canadensis 26.3 Poa compressa 49.3 Lathyrus Saivais 22.2 Poa pratensis 22.4 Lathyrus Saivais SO.2 Polygontin pensylvanictim 43.3 Lathyrus Sylvestris 31.3 Polygontin persicaria 21.6 Lathyrus Sylvestris 31.8 Polygontin persicaria 38.5 Latiri is nobilis 25.7 Potentiiia anserina 26.3 Latiri is nobilis 3O.O Potentiiia anserina 31.2 Lavandhiia iaiifolia 40.3 Poterium Sanquisorba 29.2 Leonirits cardiaca 27.0 Pteridium aquilinum 27.3 Lepidium sativum 4.1.8 Raphantis sativits 22.7 Levisticum officinale 29.0 Raphantis sativits 30.8 Levisticum officinale 44.9 Raphantis sativits 40.2 Linaria vulgaris milier 23.6 Raphantis sativits 71.5 Lintin itsitatissini in 33.3 Raphantis sativits 1OO.O Lolium multiflorum 29.0 Rheum rhabarbarium 21.3 Lolium perenne S2.O Rheum rhabarbarium 67.9 Lotus corniculatus 62.9 Rheum rhabarbarium 72.4 Lotus tetragonolobits 62.9 Ribes nidigrolaria 32.6 Lycopersicon escientiin 26.1 Ribes nidigrolaria 64.6 Lycopersicon escientiin 33.0 Ribes nigrum 23.6 Maiva moschata 31.8 Ribes nigrum 27.2 Malva Sylvestris 21.4 Ribes nigrum 410 Maiva verticiliata 43.4 Ribes nigrum 65.8 Matteucia pensylvanica 26.9 Ribes Nigrum 1OO.O Medicago Saiiva 20.4 Ribes Saivum 75.4 Meilotus aibus 53.9 Ribes Sylvestre 27.7 Melissa officinalis 21.4 Ribes Sylvestre 1OO.O Melissa officinalis 36.8 ribes uva-crispa 24.4 Melissa officinalis 53.7 Ribes Uva-crispa 36.6 Mentha piperita 57.7 Ricinits communis 21.6 Menthapulegitim 66.1 Rosa rugosa 30.6 Mentha spicaia 67.7 Rosa rugosa 36.2 Mentha suaveolens 51.8 Rosa rugosa 39.3 Monoraica charania 29.7 Rosmarinus officinalis 27.2 Monoraica charania 72.1 Rosmarinus officinalis 45.7 Nicotiana rustica 30.3 Rubus allegheniensis 53.7 Nicotiana rustica 59.1 Rubus Canadensis 27.0 Nicotiana tabacum 39.0 Rubus Canadensis 410 Nicotiana tabacum 47.6 Rubus Canadensis 41.2 Nicotiana tabacum 1OO.O Rubus Canadensis 45.1 Nigella Saiiva 59.4 Rubus idaeus 24.3 Oenothera biennis 21.3 Rubus idaeus 39.7 Oenothera biennis 36.7 Rubus idaeus 62.2 Origantim vulgare 21.3 Rubus idealis 37.0 Origantim vulgare 42.7 Rumex acetoseiia 75.8 Oryza sativa 56.5 Rumex acotosa 25.5 Oxyria digyna 35.1 Rumex crispiis 73.3 Oxyria digyna 76.4 Rumex crispiis 6O.S Pastinaca Saiiva 20.3 Rumex patientia 49.4 Pastinaca Saiiva 23.2 Rumex patientia 65.8 Pastinaca Saiiva 42.1 Rumex Scittatus 25.5 Pastinaca Saiiva 46.9 Rumex Scittatus 61.9 Phaiaris canariensis 20.3 Rumex Scittatus 93.8 Phaiaris canariensis 8O.S Rita graveolens 25.8 Phaseolus mingo 51.3 Rita graveolens 27.1 Phaseolus mingo 74.1 Salix purpurea 22.1 Phaseolus vulgaris 23.0 Salix purpurea 33.8 Phaseolus vulgaris 51.4 Salvia elegans 23.7 Phaseolus vulgaris 62.6 Salvia officinalis 20.8 Phlox paniculata 410 Salvia officinalis 31.4 Physalis alkekengi 31.6 Saivia Sciarea 28.0 Physalis ixocarpa 45.2 Satureia montana 21.7 Physalis ixocarpa 65.3 Scuttellaria laterifiora 54.1 Physalis Pruinosa 87.3 Secale cereale 22.6 Phytolacca americana 49.6 Secale cereale 22.9 Phytolacca americana 89.8 Secale cereale 26.9 Pimpinella anisum 1OO.O Sesamun indicum 21.2 Plantago Coronopus 48.3 Setaria itaica 27.0 Plantago Coronopus 89.3 Siim Sisartin 32.6 Plantago major 21.8 Siim Sisartin 42.7 Poa compressa 22.4 Soianum duticamara 43.3 US 2009/0263516 A1 Oct. 22, 2009 39

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Soianum duticamara 48.6 Allium cepa 22.5 Soianum melanocerastin 21.3 Allium cepa 60.7 Soianum melongena 2O.S Allium Schoenoprastin 21.1 Soianum melongena 35.6 Allium Schoenoprastin 60.4 Soianum melongena 49.4 Aium tuberosum 38.8 Soianum melongena 65.2 Aium tuberosum 74.4 Solidago sp 32.7 Althaea officiana is S4.9 Spinacia oleracea 410 Amaranthus candaihits 42.6 Stachys affinis 22.5 Amaranthus caudathus 27.1 Stachys affinis 43.9 Amaranthus gangeticits 56.8 Stachys affinis 92.0 Amaranthus gangeticits 74.4 Symphytum officinale 28.0 Ambrosia artemisiifolia 49.0 Tanacetum cinerariifolium 20.3 Amelanchier sanguinea 45.2 Tanacetum cinerariifolium 69.7 Angelica archangelica 20.9 Tanacetum vulgare 2O2 Anthemis nobiis S8.9 Tanacetum vulgare 84.2 Apium graveolens 30.4 Teucrium chamaedrys 20.4 Apium graveolens 36.4 Teucrium chamaedrys 20.4 Apium graveolens 60.6 Thymus serpyllum 24.3 Arachis hypogaea 26.O Thymus vulgaris 42.5 Aralia Cordata 66.O Thymus X citriodorus 27.4 Arctii in minus 26.6 Tragopogon porrifolius 21.9 Arctii in minus 30.8 Tragopogon porrifolius 26.2 Arctostaphylos tiva-lisi 29.3 Trifolium hybridum 30.9 Arctostaphylos tiva-lisi 38.8 Trifolium pannonicum 410 Arctostaphylos tiva-lisi 80.2 Trifolium repens 51.3 Armoracia rusticana 62.7 Trigonelia foentingraecum 44.2 Aronia melanocarpa 26.7 Triticum spelta 3O.O Aronia melanocarpa 1OO.O Triticum turgidium 31.3 Aronia melanocarpa 1OO.O Typha latifolia 57.7 Aronia melanocarpa (Michx.) Eil. 39.1 Urtica dioica 26.5 Artemisia dractinctiitis 44.3 Urtica dioica SO.2 Artemisia dractinctiitis 65.4 Vaccinium Corymbosum 39.9 Asclepias incarnata 20.3 Vaccinium Corymbosum 64.8 Asparagus officinalis 22.3 Vaccini in augustifolium 44.8 Asparagus officinalis 26.6 Vaccinum macrocarpon 1OO.O Asparagus officinalis 28.7 Veratrum viride 29.1 Aster sp 34.3 Veratrum viride 31.8 Aster sp 62.6 Verbascum thapsus 42.6 Atropa belladonna 34.9 Verbascum thapsus 75.2 Beta vulgaris 28.3 Viburnum trilobum 97.4 Beta vulgaris 42.2 Vicia Saiva 53.3 Beta vulgaris 47.0 Vicia viliosa 48.9 Beta vulgaris spp. Maritina 46.7 Vignatinguiculata 27.0 Brassica cepticepa 26.7 Vignatinguiculata 44.8 Brassica cepticepa 68.3 Vignatinguiculata 55.5 Brassica iuncea 45.0 Vinca minor 35.1 Brassica iuncea 66.1 Vitis sp. 52.2 Brassica Naptis 27.5 Vitis sp. 59.6 Brassica Naptis 37.6 Vitis sp. 87.8 Brassica naptis 94.8 Xanthium Sibiricum 57.1 Brassica nigra 36.4 Zea mays 26.1 Brassica oleracea 38.7 Zea mays 32.1 Brassica oleracea 39.0 Zea Mays 38.7 Brassica oleracea 49.4 Achillea millefolium 45.5 Brassica oleracea 76.1 Aconium napelius 24.O Brassica oleracea 1OO.O Aconium napelius 53.9 Brassica rapa 21.1 Acorus calamus 87.6 Brassica rapa 64.O Acorus calamus 1OO.O Brassica rapa 1OO.O Actinidia argutta 33.8 Bronts inermis 36.7 Adiantum pedatum 31.6 Campaniiia raptinctius 59.9 Adiantum pedatum 31.7 Canna eduis 20.8 Ageratum conyzoides 23.1 Canna eduis 83.1 Agropyron cristatum 64.1 Capsicum annium 2O2 Agropyron repens 29.2 Capsicum annium 29.6 Agropyron repens 32.6 Capsicum annium 51.5 Agrostis Stoionifera 34.4 Capsicum annium 60.8 Alcea rosea 22.7 Capsicum finitescens 32.8 Aichemia nois 3O.S Carthamus tinctorius 29.8 Aichemia nois 33.2 Cartin carvi 30.4 Allium ampeioprastin 53.4 Chelidonium maius 39.9 US 2009/0263516 A1 Oct. 22, 2009 40

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Chenopodium bonus-henricus 63.0 Glycyrrhiza glabra 21.4 Chenopodium quinoa 34.1 Glycyrrhiza glabra 21.6 Chenopodium quinoa 42.8 Glycyrrhiza glabra 1OO.O Chenopodium quinoa 46.1 Guizotia abyssinica 91.4 Chichorium endivia subspendivia 22.O Hamamelis virginiana 39.8 Chichorium endivia subspendivia 22.9 Hamamelis virginiana 78.8 Chrysanthemum coronarium 23.2 Hamamelis virginiana 96.6 Chrysanthemum coronarium 68.4 Hedeona ptilegioides 45.4 Chrysanthemum leucanthemum 2O.S Helenium hoopesii 22.6 Cicer arietintin 25.7 Helenium hoopesii 52.8 Cichorium intybus S1.1 Helianthus annuit is 22.O Cichorium intybus 53.4 Helianthus annuit is 31.6 Citritius ianatus 36.5 Heianthus strumosus 3O.S Citritius ianatus 71.5 Heianthus strumosus 71.7 Coix Lacryma-Jobi 21.O Heianthus tuberosus 21.2 Cornus Canadensis 34.8 Heianthus tuberosus 50.7 Crataegus sp S4O Heianthus tuberosus L. 24.9 Crataegus Suibnois 31.3 Heliotropium arborescens 40.O Cryptotaenia Canadensis 32.1 Heliotropium arborescens 45.6 Cuctimis anguria 27.3 Helleborus niger 38.0 Cuctimis anguria 32.5 Hordeum vulgare 21.5 Ciclinissativits 39.4 Huntilus lupulus 35.1 Ciclinissativits 69.4 Hyperictim sp 26.1 Cucurbita maxima 34.1 Hyssopus officinalis 74.5 Cucurbita maxima 42.6 Iberis amara 20.9 Cucurbita moschata 32.O Iberis amara 21.7 Cucurbita moschata 39.2 Initia heienium 27.6 Cucurbitapepo 28.8 Ipomoea batatas 37.5 Cucurbitapepo 32.6 Isais inctoria 48.0 Curcuna Zedoaria 23.3 Lachica Serroia 53.0 Curcuna Zedoaria 57.6 Lactica Saiiva 24.5 Cymbopogon citratus 70.1 Laportea Canadensis 36.0 Cynara Scolymis 2O2 Laportea Canadensis 81.7 Cynara Scolymis 37.5 Lathyrus Saivais 37.8 Cynara Scolymis 88.7 Lathyrus Sylvestris 40.7 Cypertis escientiis 66.7 Lathyrus Sylvestris 79.1 Datura meiei 29.2 Latiri is nobilis 22.7 Daitira Stranonium 27.6 Lavandhiia anglisiifolia 31.7 Daiiciis Caroia 24.2 Lavandhiia iaiifolia 27.2 Daiiciis Caroia 29.3 Ledum groenlandictim 61.1 Dipsactis Saivais 48.7 Leonirits cardiaca 22.6 Dirca palustris 29.9 Lepidium sativum 23.3 Dirca palustris 36.4 Levisticum officinale 23.1 Doichos Labiah 35.8 Levisticum officinale 27.5 Doichos Labiah 74.5 Levisticum officinale 41.3 Dryopteris filix-mas 27.9 Lintin itsitatissini in 21.4 Dryopteris filix-mas 42.6 Lolium perenne 32.7 Echinochloa frumentacea 68.4 Lotus corniculatus 54.2 Eleusine coracana 47.8 Maius hupehensis 26.4 Elymaisincetts 42.7 Maiva verticiliata 37.9 Erigeron Canadensis 37.8 Matricaria recitita S.O.3 Erigeron speciosus 34.6 Medicago Saiiva 29.1 Errhenaiherineiatius 34.4 Meilotus aibus S2.1 Fagopyrim tariarictim 31.4 Melissa officinalis 22.7 Foeniculum vulgare 28.0 Melissa officinalis 35.9 Foeniculum vulgare 44.6 Melissa officinalis 38.6 Foeniculum vulgare 68.9 Mentha piperita 64.4 Foeniculum Vulgare 1OO.O Mentha suaveolens 22.5 Forsythia intermedia 1OO.O Monoraica charania 29.3 Forsythia X intermedia 79.5 Monoraica charania 90.6 Gaium odoratum 32.4 Nepeta Cataria 50.5 Gaium odoratum 1OO.O Nicotiana rustica 35.3 Gaultheria hispidula 48.4 Nicotiana rustica 1OO.O Gaultheria hispidula 80.4 Nicotiana tabacum 31.6 Gaultheria hispidula 1OO.O Nicotiana tabacum 1OO.O Gaultheria procumbens 26.9 Nigella Saiiva 24.2 Gaultheria procumbens S4.3 Ocimum basilicum 30.6 Giechona hederacea 26.6 Oenothera biennis 48.0 Glycine max 52.5 Oenothera biennis 76.6 Glycine max 67.9 Origantim vulgare 41.3 Glycine max 75.8 Oryza Sativa 22.1 US 2009/0263516 A1 Oct. 22, 2009 41

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Oxyria digyna 26.5 Rumex Scittatus 23.8 Oxyria digyna 70.3 Rumex Scittatus 69.9 Panicum miliaceum 94.4 Rumex Scittatus 78.8 Pastinaca Saiiva 29.4 Rita graveolens 30.7 Pastinaca Saiiva 79.2 Rita graveolens 61.5 Pennisetum alopectiroides 22.O Salvia elagens 25.4 Petasitesiaponicus 29.2 Salvia elegans 31.1 Peucedanum of easeinum 21.3 Sambucus Canadensis 80.6 Phacelia tanacetifolia 23.5 Sambucus ebulus 26.1 Phaiaris arundinacea 47.5 Sambucus ebulus 34.4 Phaiaris canariensis 23.1 Sambucus ebulus 37.8 Phaiaris canariensis 1OO.O Sanguisorba officinalis 1OO.O Phaseolus coccineus 37.0 Santolina Chamaecyparissils 21.7 Phaseolus coccineus 74.1 Santolina Chamaecyparissils 25.2 Phaseolus mingo 42.2 Satureia montana 21.2 Phaseolus mingo 52.2 Scutiellaria laterifiora 37.0 Phaseolus vulgaris 35.5 Secale cereale 26.7 Phaseolus vulgaris 48.0 Secale cereale 27.3 Phaseolus vulgaris S8.1 Serrainia tinctoria 36.2 Phlox paniculata 32.2 Serrainia tinctoria 70.3 Phlox paniculata 40.1 Sesamun indicum 27.6 Physalis-ixocarpa 20.6 Sesamun indicum 44.3 Physalis pruinosa 80.0 Silybum marianum 34.7 Phytolacca americana 62.O Siim Sisartin 79.0 Phytolacca americana 1OO.O Soianum duticamara 25.2 Pimpinella anisum 37.3 Soianum duticamara 64.6 Pistin Saivain 34.4 Soianum melongena 36.6 Pistin Saivain 6.3.3 Solanum melongena 40.1 Plantago Coronopus 42.7 Soianum melongena SO.O Plantago Coronopus 46.4 Soianum melongena 74.9 Plantago major 28.3 Soianum tuberosum 39.1 Plantago major 41.4 Soianum tuberosum 39.2 Plectranthus sp. 29.3 Solidago Sp 30.7 Poa compressa 22.1 Sorghum cafiorum 87.9 Poa compressa 45.5 Sorghum dochna 20.6 Poa pratensis 35.7 Sorghum dochna 20.6 Polygontin pensylvanictim 38.3 Sorghum dochna 34.1 Polygontin persicaria 31.0 Sorghum dochna 97.0 Potentiiia anserina 46.8 Sorghum durra 30.6 Poterium sanquisorba 24.7 Sorghum durra 30.6 Poterium sanquisorba 30.6 Sorghum durra 48.0 Prunus cerasifera 45.9 Sorghum Sudanense 21.7 Pteridium aquilinum 22.4 Sorghum Sudanense 24.6 Raphantis Raphanistrain 36.5 Sorghum Sudanense 32.1 Raphantis Raphanistrain 75.O Spinacia oleracea 53.2 Raphantis sativits 20.8 Stachys Afinis 2S.O Raphantis sativits 27.5 Stachys Afinis 27.8 Raphantis sativits 35.4 Stachys-Affinis 1OO.O Rheum rhabarbarium 27.0 Symphytum officinale 21.7 Ribes Grossiliaria 33.7 Symphytum officinale 25.2 Ribes nidigrolaria 30.7 Symphytum officinale 34.6 Ribes nidigrolaria 40.5 Tanacetum cinerariifolium 52.4 Ribes nigrum 35.9 Tanacetum vulgare 27.1 Ribes nigrum 58.6 Tanacetum vulgare 72.7 Ribes Silvestris 26.9 Teucrium chamaedrys 24.6 Ribes Silvestris 1OO.O Teucrium chamaedrys 52.8 Ricinits communis 21.8 Thymus fragantissuinus 1OO.O Rosmarinus officinalis 24.7 Thymus vulgaris 24.2 Rosmarinus officinalis 30.9 Thymus X citriodorus 23.7 Rosmarinus officinalis 60.3 Tiarella cordifolia 20.8 Rubus idealis 32.5 Tiarella cordifolia 30.8 Rubus idealis 47.0 Tragopogon porrifolius 22.8 Rubus occidentais 39.4 Trifolium hybridum 24.7 Rubus occidentais 74.1 Trifolium pannonicum 65.5 Rumex acetosa 45.6 Trifolium repens 57.5 Rumex acetoseiia 22.8 Trigonelia foentingraecum 37.6 Rumex acetoseiia 31.5 Triticum fungidum 56.5 Rumex crispiis 25.9 Triticum spelta 40.8 Rumex crispiis 70.3 Tropaeoluim maints 76.1 Rumex patientia 39.8 Typha latifolia 43.3 Rumex patientia 54.2 Urtica dioica 40.3 US 2009/0263516 A1 Oct. 22, 2009 42

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Vaccinium anglisiifolium 42.4 Amelianchierainitoia 70.5 Vaccinium corymbosum 61.5 Amelanchier sanguinea 37.3 Vaccinium macrocarpon 43.7 Ananas Conostis 23.8 Vaccinium anglisiifolium 23.1 Ananas Conostis 95.0 Veratrum viride 43.6 Ananas Conostis 99.6 Verbascum thapsus 37.8 angelica archangelica 3O.S Verbascum thapsus 87.O angelica archangelica 38.9 Veronica officinalis 3O.S Anthemis nobiis 41.4 Viburnum trilobum 49.4 Anthemis nobiis 72.8 Viburnum trilobum 1OO.O Anthemistinctorium 27.3 Viburnum trilobum 1OO.O Anthriscus cerefolium 35.8 Vicia faba 50.5 Apium graveolens 31.7 Vicia Saiva 42.4 Apium graveolens 32.4 Vicia viliosa 89.2 Apium graveolens 56.6 Vigna angularia 28.1 Aralia Cordata 29.2 Vigna angularia 71.5 Aralia Cordata 45.0 Vignatinguiculata 21.O Arctii in minus 25.8 Vignatinguiculata 38.7 Arctostaphylos tiva-lisi 31.0 Vignatinguiculata 61.1 Arctostaphylos tiva-lisi 35.2 Vinca minor 33.6 Arctostaphylos tiva-lisi 58.6 Vinca minor 34.3 Armoracia rusticana 24.9 Vitis sp. 29.0 Armoracia rusticana S2.9 Vitis sp. SO.2 Aronia melanocarpa 40.O Vitis sp. 53.3 Aronia melanocarpa 91.9 Vitis sp. 63.0 Aronia prunifolia 1OO.O Vitis sp. 86.6 Arrhenaiherum eiatius 22.8 Withania somnifera 20.3 Artemisia draculus 74.9 Xanthium Sibiricum 34.7 Artemisia dractinctiitis 47.8 Xanthium strumarium 23.2 Asclepias incarnata 2O.S Zea mays 20.1 Asciinidia chinensis 43.4 Zea mays 45.9 Asciinidia chinensis 66.4 Zea mays 97.5 Asparagus officinalis 91.3 Abelnochtis escientiis 24.8 Asparagus officialis 23.3 Abies lasiocarpa 44.7 Asparagus officialis 44.7 Achillea millefolium 24.1 Aster Linné 47.5 Achillea millefolium 59.2 Aster sp 62.O Aconium napelius 40.6 Atriplex hortensis 54.6 Aconium napelius 41.6 Atropa belladonna 20.1 Acorus calamus 47.1 Atropa belladonna S1.O Actinidia argutta 21.8 Avena Saiiva 24.8 Adiantum pedatum 26.8 Avena Saiiva 26.4 Adiantum pedatum 45.8 Averrhoa Caramboia 23.4 Adiantum pedatum 86.0 Apertis escientiis 46.2 Agarict is bisports 26.3 Beta vulgaris 28.2 Agarict is bisports 29.8 Beta vulgaris 30.4 Agarict is bisports 36.9 Beta vulgaris 56.8 Agarict is bisports 44.0 Beta vulgaris spp. Maritina 23.6 Agarict is bisports 46.0 Betula glanditiosa 22.2 Agastache foeniculum 70.O Betula glanditiosa 22.2 Ageratum conyzoides 31.7 Betula glanditiosa 25.7 Agropyron cristatum 86.9 Betula glanditiosa 32.9 Agropyron repens 49.6 Boietus eduis 36.2 Agrostis alba 21.9 Boietus eduis 90.2 Agrostis Stoionifera 35.8 Borago officinalis 27.9 Alcea rosea 35.2 Borago officinalis 76.1 Aichemia nois 37.9 Brassica cepticepa 65.4 Allium ampeioprastin 48.0 Brassica cepticepa 71.5 Allium ascalonictim 26.2 Brassica Chineusis 27.1 Allium ascalonictim 77.2 Brassica iuncea S1.O Allium cepa 92.6 Brassica iuncea 66.O Allium grande 60.4 Brassica iuncea 74.1 Allium Schoenoporastin 65.8 Brassica Naptis 22.O Allium Schoenoprastin 31.0 Brassica Naptis 34.O Aium tuberosum 22.8 Brassica Naptis 1OO.O Aium tuberosum 99.7 Brassica nigra 26.7 Althaea officiana is 22.8 Brassica nigra 27.4 Althaea officinalis 22.1 Brassica nigra 82.5 Amaranthus candaihits 43.9 Brassica oleracea 21.2 Amaranthus gangeticits 30.3 Brassica oleracea 22.1 Amaranthus gangeticits 66.O Brassica oleracea 26.2 Ambrosia artemisiifolia 58.7 Brassica oleracea 27.2 US 2009/0263516 A1 Oct. 22, 2009 43

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Extrait (%) Nomlatin Extrait (%) Brassica oleracea 31.3 Cucumissativus Fanfare 40.3 Brassica oleracea 46.5 Cucurbita maxima 23.6 Brassica oleracea 71.2 Cucurbita maxima 33.1 Brassica oleracea 93.5 Cucurbita maxima 55.2 Brassica rapa 25.6 Cucurbita moschata 20.1 Brassica rapa 33.9 Cucurbita moschata 26.7 Brassica rapa 56.0 Cucurbita moschata 41.7 Brassica rapa 69.7 Cucurbitapepo 41.9 Brassica rapa 1OO.O Cucurbitapepo 82.9 Bronts inermis 57.3 Curcuna Zedoaria 1OO.O Campaniiia raptinctius 77.5 Cydonia oblonga 42.9 Canna eduis 75.6 Cynara Scolymis S1.6 Canthareilus ciparium 52.5 Cynara Scolymis 60.9 Capsella bursa-pastoris 35.9 Dactiis Giomerata 25.7 Capsicum annis 43.9 Daitira Stranonium 21.9 Capsicum annittin SO.1 Daiiciis Caroia 25.9 Capsicum finitescens 28.9 Dioscorea batatas 47.6 Carica papaya 31.1 Dioscorea batatas 83.1 Carthamus tinctorius 37.3 Diospiros Kaki 34.9 Cartin carvi 30.1 Dirca palustris 27.6 Castanea spp. 21.7 Dirca palustris 90.4 Chaerophyllum bulbosum 46.0 Doichus iabiah 66.4 Chamaemeium nobile 36.8 Doichus iabiah 85.3 Chamaemeium nobile 48.4 Dryopteris filix-mas 21.9 Chelidonium maius 46.6 Dryopteris filix-mas 77.9 Chenapodium bonus-henricus 22.4 Echinacea purpurea 48.6 Chenopodium bonus-henricus 57.6 Eleusine Coracana 45.2 Chenopodium quinoa 35.5 Elymus iunceus 410 Chenopodium quinoa 54.4 Erigeron Canadensis 31.4 Chrysanthemum leucanthemum 26.5 Eriobotrya japonica 28.3 Chrysanthemun coronarium (Chip Suey) 48.4 Erica vesicaria 44.9 Chrysanthemum coronarium 38.2 Fagopyrim escattenium 76.7 Chrysanthemum coronarium 63.9 Fagopyrim tariarictim 42.6 Cicer arietintin 2O.O Festuca rubra 29.6 Cichorium endi via 25.6 Festuca rubra 42.9 Cichorium endivia crispa 38.4 Foeniculum vulgare 22.1 Cichorium intybus 30.2 Foericulum vulgare 21.6 Cinicifiiga racemosa 33.7 Foericulum vulgare 84.8 Citrulius colocynthus 20.4 Forsythia intermedia 70.8 Citritius ianatus 68.3 Forsythia X intermedia 60.2 Citritius ianatus 31.9 Fortunella spp 35.7 Citrus innettoides 20.4 Fortunella spp 50.7 Citrus innettoides 37.5 Fortunella spp 74.5 Citrus innon 47.7 Fragaria 24.8 Citrus innon 72.4 Fragaria 52.4 Citrus paradisi 23.8 Fragaria 1OO.O Citrus paradisi 33.4 Fragaria Xananassa 29.3 Citrus reticulata 20.4 Gaium odoratum 26.O Citrus reticulata 20.9 Gaultheria hispidula 40.3 Citrus reticulata 26.O Ginkgo biloba 27.0 Citrus reticulata 40.4 Ginkgo biloba 68.9 Citrus reticulata SO.O Giechona hederacea 20.4 Citrus reticulata 79.2 Giechona hederacea 30.4 Citrus Sinensis 25.3 Glycine max 26.6 Citrus Sinensis 59.8 Glycine max 47.4 Coix Lacryma-Jobi 2O.O Glycine max 82.O Corchorus oitorius 38.9 Glycyrrhiza glabra 35.4 Cornus Canadensis 35.6 Glycyrrhiza glabra 40.5 Cosmos sulphureus 51.4 Glycyrrhiza glabra 1OO.O Crataegus sp 28.0 Gossypium herbaceum 36.1 Crataegus sp 60.9 Guizotia abyssinica 28.9 Crataegus Suibnois 25.5 Guizotia abyssinica 40.4 Crithmin maritima SO.6 Hamamelis virginiana 52.4 Cryptotaenia Canadensis 21.2 Hamamelis virginiana 67.5 Cryptotaenia Canadensis 26.O Hamamelis virginiana 84.1 Cryptotaenia Canadensis 40.O Hedeona ptilegiodes 57.4 Cuctimis anguria 38.7 Helenium hoopesii 33.7 Cuctimis anguria 46.6 Helenium hoopesii 49.0 Cucumis meio 30.3 Heianthus annus 53.4 Cucumis meio 46.2 Heianthus strumosus 20.3 Cucumis meluliferus 32.O Heianthus strumosus 71.7 US 2009/0263516 A1 Oct. 22, 2009 44

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Extrait (%) Nomlatin Extrait (%) Heianthus tuberosa 22.8 mentha arvensis 53.7 Heianthus tuberosus L. 22.6 Mentha suaveolens 26.8 Heianthus tuberosus L. 55.0 Menyanthes trifoliata 32.8 Helichrysum angustifolium 67.0 Miscanthus sinensis Andress 22.7 Heliotropium arborescens S8.9 Monoraica charania 55.5 Helleborus niger 31.9 Monarda didyma 26.8 Hibiscus cannabinus 48.9 Monarda fistulosa 21.5 Hordeum vulgare 29.2 Montia perfoliata 26.6 Huntilus lupulus 22.4 Musa paradisiaca 29.0 Huntilus lupulus 39.1 nastairtium officinale 35.4 Huntilus lupulus 63.1 Nepeta Cataria 26.5 Huntilus lupulus 1OO.O Nepeta Cataria 27.5 Hydrastis Canadensis 2O2 Nepeta Cataria 41.9 Hydrastis Canadensis 31.0 Nephelium longana ou Euphoria longana 43.4 Hyoscyami is niger 56.8 Nicotiana rustica 26.O Hypericum hennyi 48.8 Nicotiana rustica 32.7 Hyperictim perforatin 48.1 Nicotiana tabacum 25.1 Hyperictim perforatin 63.7 Nicotiana tabacum 77.7 Hypomyces lactiflorum 44.8 Nigella Saiiva 59.3 Hypomyces lactiflorum 60.9 Nigella Saiiva 1OO.O Hyssops officinalis 22.9 Ocimum Basilicum 2O2 Initia heienium 24.6 Ocimum Basilicum 2O2 Juniperus communis 33.0 Ocimum Basilicum 32.8 Juniperus communis 38.2 Oenothera biennis linné 1OO.O Lactica Saiiva 44.5 Onobrychis viciafolia 45.0 Lactica Saiiva 50.7 Optainia sp. 33.4 Laportea Canadensis 30.2 Origantin nationara 2O.S Lathyrus Saiivus 20.4 Origanum vulgare 20.8 Lathyrus Saiivus 52.5 Origantim vulgare 21.6 Lathyrus Sylvestris 27.7 Oryza sativa 42.4 Lathyrus Sylvestris 36.8 Oxyria digyna 57.0 Latiri is nobilis S2.O Oxyria digyna 77.9 Lavendula angustifolia 26.4 Panax quinquefolius L. 23.5 Lavendula angustifolia 53.2 Panicum miliaceum 36.5 Lavenditia iaiifolia 51.3 Passiflora spp 35.8 Ledum groenlandictim 44.4 Passiflora spp 38.3 Lentinus edodes 42.1 Passiflora spp 46.2 Lentinus edodes 1OO.O Passiflora spp 1OO.O Lepidium sativum 44.2 Pastinaca Saiiva 21.7 Levisticum officinale 20.8 Pastinaca Saiiva 38.6 Levisticum officinale 39.4 Pastinaca Saiiva 39.2 Lintin itsitatissini in 42.3 Persea americana 32.5 Litchi chinensis 25.7 Persea americana 38.6 Lolium multiflorum 20.6 Petasites Japonicus 26.2 Lolium perenne 28.7 Phaiaris canariensis 80.0 Lonicera ranosissina 26.3 Phaseolus coccineus 44.4 Lonicera ranosissina 40.4 Phaseolus coccineus 79.1 Lonicera ranosissina 53.2 Phaseolus mingo 27.0 Lonicera syringantha 95.8 Phaseolus mingo 37.9 Lotus corniculatus 1OO.O Phaseolus vulgaris 20.1 Lotus tetragonolubits 65.4 Phaseolus vulgaris S1.9 Linaria annia 55.7 Phaseolus vulgaris 61.7 Linaria annia 67.3 Phlox paniculata 22.9 Lycopersicon escientiin 37.6 Phlox paniculata 44.5 Maius 31.8 Phoenix dactylifera 29.6 Maius 44.4 Physalis alkekengi 32.9 Maius hupehensis (Pamp.) Rehd. 26.3 Physalis ixocarpa 26.6 Maius hupehensis (Pamp.) Rehd. 67.0 Physalis ixocarpa 28.3 Maius sp. 65.3 Physalis pruinosa 27.3 Maiva moschata 41.1 Physalis pruinosa 47.8 Malva Sylvestris 36.4 Physalis pruinosa 93.1 Malva Sylvestris 47.4 Physalis sp 39.1 Maiva verticiliata 42.7 Physalis sp 60.8 Mangifera indica 3O.S Phytolacca americana 4.1.8 Manihot esculenta syn. M. utilissima 38.3 Phytolacca americana 1OO.O Manihot esculenta syn. M. utilissima SO.4 Phytolacca decandra syn. P. americana 85.9 Manihot esculenta syn. M. utilissima 86.5 Pimpinella anisum 2O2 Meilotus aiba 30.4 Pimpinella anisum 68.4 Melilotus officinalis 68.1 Pistin Saivain 20.1 Melissa officinalis 33.7 Pistin Saivain 25.8 Melissa officinalis 34.7 Pistin Saivain 27.0 US 2009/0263516 A1 Oct. 22, 2009 45

TABLE 4-continued TABLE 4-continued

MMP-9 MMP-9

Inhibition Inhibition Nom latin Extrait (%) Nomlatin Stress Extrait (%) Pistin Saivain 51.8 Rubus occidenia is O 21.4 Plantago Coronopus 21.9 Rubus occidenia is S 36.5 Plantago Coronopus 48.6 Rubus occidenia is R 60.2 Plantago Coronopus 66.8 Rimes Scittatus O 84.5 Plantago major 35.1 Rumex crispus linné O 52.5 Pleurotus spp 25.3 Rumex crispus linné R 1OO.O Pleurotus spp 59.3 Rumex patientia O 23.1 Pleurotus spp 85.2 Rumex patientia S 65.8 Poa compressa 26.2 Rita graveolens S 37.2 Poa pratensis 21.5 Sabal Serrutiaia syn. Serenoa repens V 34.4 Poa pratensis 3O.O Sabal Serrutiaia syn. Serenoa repens S 44.6 Podophyllum peltatum 33.9 Salix purpurea R 67.8 Podophyllum peltatum SO.2 Salvia (elegens) O S1.1 Polygonum aviculare linné 31.0 Sambucus Canadensis S 44.8 Polygontin pennsylvanicum 56.6 Sambucus Canadensis O 72.4 Polygontin persicaria 20.1 Sambucus Canadensis L. W 67.8 Populus incrassata S4.9 Sambucus ebulus V 44.3 Populus Tremula 31.0 Sanguisorba officinalis R 1OO.O Popitius Xpetrowskyana 1OO.O Santoina R 37.9 Potentiiia anserina 22.1 Satureia montana S 2O.O Potentiiia anserina 41.1 Satureia montana O 21.3 Prints cerastis 30.1 Satureia repandra S 36.3 Prunus persica 26.6 Scorzorera hipanica R 27.1 Prunus persica 38.5 Scorzorera hipanica S 31.7 Prunus spp 24.O Scuttellaria laterifiora S 44.3 Prunus spp 49.1 Secale cereale S 24.2 Psidium guaiaba 22.5 Secale cereale W 31.1 Psidium guajaba 44.3 Sechium edule S 37.8 Psidium guaiaba 95.4 Sesamun indicum S 59.2 Psidium spp 36.6 Setaria itaica W 33.0 Psidium spp 47.6 Silybum marianum O 92.4 Psidium spp 87.6 Siim Sisartin O 32.7 Pteridium aquilinum 22.O Siim Sisartin S 33.1 Punica granaium S2.1 Siim Sisartin O 813 Pyrus communis 39.5 Soianum melogena O 21.9 Pyrus pyrifolia 33.7 Soianum melogena V 26.1 Raphantis raphanistrain 24.5 Soianum melogena R 34.O Raphantis raphanistrain 44.8 Soianum melogena S 67.1 Raphantis raphanistrain 46.1 Soianum Tiiberosum O 68.6 Raphantis sativits 25.4 Solidago Canadensis S 48.4 Raphantis sativits 32.1 Solidago Sp R 31.4 Raphantis sativits 38.1 Solidago virgatirea S 56.2 Raphantis sativits 63.6 Sorghum cafiorum O 23.3 Raphantis sativits 93.4 Sorghum dochna bicolor gr technicum W 20.8 Reseda luteola 22.5 Sorghum dochna Snowdrew S 21.4 Rhamnus fianguia 34.2 Sorghum dochna Snowdrew O 27.7 Rhamnus fianguia 39.5 Spinacia oleracea V 2S.O Rheum officinale 1OO.O Spinacia oleracea W 32.1 Rheum palmatum 2O2 Spinacia oleracea S 47.6 Rheum rhabarbarium 33.8 Spinacia oleracea O 63.1 Rianits communis 20.9 Stachys affinis R 31.7 Ribes nidigrolaria 44.5 Stachys affinis O 1OO.O Ribes nidigrolaria 53.1 Stachys byzantina W 30.9 Ribes nigrum 40.7 Stipa capillaia L. R 20.1 Ribes nigrum L. SO.O Symphytum officinale S 24.1 Ribes nigrum L. 60.1 Tanacetum cinerarifolium O 24.2 Ribes sativam Syme 47.9 Tanacetum cinerarifolium R 84.4 Ribes Saiivum 48.2 Tanacetum vulgare R 25.7 Ribes SilveStre 26.3 Tanacetum vulgare S 75.6 Ribes SilveStre 1OO.O Taraxacum officinale (Red ribe) S 21.1 Ribes tiva-crispa 57.5 Teparty R 56.7 Rosa rugosa 27.8 Teucrium chamaedrys L. R 27.3 Rosa rugosa thunb. 37.5 Thalipsi arvense S 61.4 Rosa rugosa thunb. 45.7 Thymus fragantissuinus R 1OO.O Rosmarinum officinalis 44.2 Thymus herba-barona W 22.O Rosmarinum officinalis 65.9 Thymus pseudoianuginostis R 36.8 Rubus Canadensis 45.5 Thymus pseudoianuginostis S 37.1 Rubus idaeus 31.4 Thymus serpyllum S 26.O Rubus idaeus 57.2 Thymus serpyllum W 42.7 Rubus idealis 28.5 Thymus X citriodorus O 22.7 Rubus idealis 38.0 Tiarella cordifolia R 1OO.O US 2009/0263516 A1 Oct. 22, 2009 46

TABLE 4-continued TABLE 5

MMP-9 Cath B

Inhibition Nomlatin Stress Extrait Inhibition (%) Nom latin Extrait (%) Achillea millefolium 61.9 Tragopogon porrifolius 26.8 Achiea tomentosa 60.8 Aconittin 38.6 Tragopogon porrifolius 28.4 Aconium napeiitis 61.1 Tragopogon porrifolius 42.1 Aichemia nois 26.7 Tragopogon sp. 20.3 Aium 43.O Tragopogon sp. 32.O Allium cepa gr. Cepa 49.9 Tragopogon sp. 66.3 Allium cepa gr. Cepa 70.1 Trichosanthes kirillowii 66.5 Allium cepa gr. Cepa 45.8 Trifolium incarnatum 47.9 Aium sativum 25.6 Trifolium repens 81.7 Aium Tuberosum 91.5 Trigonelia foentingraecum 39.6 Aium Tuberosum 75.0 Triticale sp. 64.1 Aium victoriais 31.1 Trictim aestivum 24.5 Amaranthus gangeticits 26.1 Trictim aestivum 29.4 Amaranthus gangeticits 29.0 Triticum fungidumm 35.8 Amelianchier Canadensis 28.7 Triticum spelta 34.7 Anthemistinctoria 26.8 Tropaeoluim maints 90.3 Anthemistinctoria 32.4 Anthoxanthum odoratum 24.9 Tropaeoluim maints 20.1 31.1 21.5 Apium graveolens Tsuga Candadensis Apium graveolens 20.6 Tsuga Candadensis 64.4 Aralia Cordata 52.3 Tsiiga diversifolia 45.9 Arctii in lappa 33.7 Tsiiga diversifolia 1OO.O Arctii in lappa 33.0 Tsuga F. macrophylia 28.1 Aronia melanocarpa (Michx.) Eil. 41.2 Typha latifolia L. 30.6 Aronia melanocarpa (Michx.) Eil. 21.6 Urtica dioica 31.4 Asartin europaeum 24.9 Urtica dioica 36.9 Athaea officinalis 57.7 Urtica dioica 41.7 Athyrium asperum 27.3 Vaccinium anglisiifolium 25.2 Atropa belladonna 37.7 Vaccinium anglisiifolium 34.6 Begonia convolvulacea 26.0 Vaccinium anglisiifolium 59.6 Begonia emini 34.2 Vaccinium anglisiifolium 65.7 Begonia glabra 38.9 Vaccinium macrocarpon 30.2 Begonia Hannii S2.9 Vaccinium macrocarpon 39.0 Begonia polygonoides 67.3 Vaccinium macrocarpon 56.9 Berberis vulgaris 54.6 39.9 39.2 Beta vulgaris Vaccinum macrocarpon Beta vulgaris 30.4 Vaccinum macrocarpon 42.3 Beta vulgaris 61.9 Veratrum viride 2O.S Beta vulgaris 43.O Veratrum viride 33.1 Beta vulgaris 91.0 Verbascum thapsus 43.1 Beta vulgaris 46.7 Verbascum thapsus 70.2 Beta vulgaris 65.3 Veronica officinalis 2O.S Beta vulgaris 33.4 Viburnum trilobum Marsh. 40.6 Beta vulgaris S4.3 Vicia taba 61.5 Beta vulgaris 38.2 Vicia Saiva 30.1 Beta vulgaris 55.9 Vigna angularia 32.6 Beta vulgaris 28.5 Vigna angularia 642 Beta vulgaris 40.1 Vignatinguiculata 32.4 Beta vulgaris spp. Maritina 33.4 Vignatinguiculata 47.4 Brassica iuncea 21.3 Vignatinguiculata S1.O Brassica Oieracea 27.5 Vinca minor 21.3 Brassica Oieracea 48.2 20.8 28.3 Brassica rapa Vitis sp. 35.6 29.4 Calendula officinalis Vitis sp. Cameliia Sinensis syn. Thea Sinensis 24.4 Vitis sp. 45.4 Cana eduis 1OO.O Vitis sp. 50.7 Capsicum annium 2S.O Vitis sp. 61.6 Capsicum finitescens 29.6 Vitis sp. 1OO.O Chrysanthemum balsamita 89.3 Weigela coracensis 35.5 Chrysanthemun balsamina 55.0 Withania somnifera 35.5 Chrysanthemun coronarium (Chip Suey) 30.1 Xanthium Sibiricum 38.6 Chrysanthemun coronarium (Chip Suey) 36.4 1OO.O Xanthium strumarium 33.5 Cichorium intybus Citritius ianatus 24.4 Zea mays 37.1 Convailiaria maia is 57.0 Zea mays 65.5 Coriandrum sativum 20.8 Zingiber officinale 20.1 Cryptotaenia Canadensis 20.4 Zingiber officinale S8.9 Clictimis Anguria 26.8 Zingiber officinale 75.9 Ciclinissativits 45.6 Curburbita pepo 30.8 Daiiciis Caroia 68.8 US 2009/0263516 A1 Oct. 22, 2009 47

TABLE 5-continued TABLE 5-continued

Cath B Cath B Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Daiiciis Caroia 20.3 Vaccini in augustifolium 67.2 Daiiciis Caroia 72.5 Vaccinum macrocarpon 37.1 Daiiciis Caroia 22.6 Vitia sp. 93.7 Daiiciis Caroia 25.6 Xanthium strumarium 83.2 Daiiciis Caroia 65.9 Yicca filamentosa 34.5 Daiiciis Caroia 77.3 Zea mayS 29.7 Daiiciis Caroia 41.6 Zea mayS 93.2 Dirca palustris 1OO.O Achiea tomentosa 41.O Erica vesicaria 41.4 Adiantum tenertin 30.2 Filipendula rubra 6S.O Alcea rosea 37.7 Forsythia intermedia 1OO.O Aichemia nois 32.8 Forsythia X intermedia 1OO.O Allium Schoenoporastin 49.3 Geum rivate 26.4 Aium tuberosum 79.1 Glycyrrhiza glabra 86.8 Aium tuberosum 774 Heliotropium arborescens 29.5 Aium victoriais 45.5 Huntilus Lupitius 65.4 Althaea officinalis 67.2 Huntilus Lupitius 1OO.O amaranthus gangeticus 23.5 Hylotelephium 23.7 Anaphalis margaritacea 34.7 Hypericum hennyi 44.4 Angelica dahirica 27.9 Iberis sempervirens 846 Anthemis nobiis 423 Jeffersonia diphylla 35.4 Apium graveolens 25.7 Ligularia dentata 30.3 Apium graveolens 27.4 Lonicera ranosissina 48.7 Arotostaphylos tiva-lisi 94.5 Miscanthus saccharifiorus SO.9 Aronia melanocarpa 74.5 Nicotiana tabacum 40.O Aronia melanocarpa 21.3 Nicotiana tabacum 56.8 Aronia melanocarpa (Michx.) Eil. 79.9 Nicotiana tabacum 55.2 Aronia melanocarpa (Michx.) Eil. 28.3 Nigella Saiiva 40.3 Asartin europaeum SS.4 Origanum majorana 49.7 Atropa belladonna S8.9 Origantim vulgare 67.0 Begonia emini 24.7 Origantim vulgare 39.9 Begonia glabra 42.9 Panax quinquefolius L. 24.O Begonia mani 32.1 Pastinaca Saiiva 33.5 Begonia polygonoides 38.2 Petroselinum crispum 70.2 Berberis vulgaris 423 Peucedanum cervaria 21.5 Beta vulgaris 75.3 Phaseolus Vulgaris 67.9 Beta vulgaris 28.7 Philadelphus coronarius 24.O Beta vulgaris 21.7 Physostegia virginiana 56.9 Beta vulgaris 40.O Phytolacca americana 1OO.O Beta vulgaris spp. Maritina 31.4 Plantago major 31.2 Betula glanditiosa 38.5 Plectranthus fruticosus 32.1 Calendula officinalis 36.2 Polygontin pennsylvanicum 70.1 Capsicum annis 49.9 Pulmonaria saccharata 31.1 Chrysanthemum balsamita 1OO.O Raphantis sativits 21.5 Chrysanthemun balsamina 33.1 Raphantis sativits 50.5 Cynara Scolymis S1.9 Raphantis sativits S8.9 Daiiciis Caroia 813 Ribes nigrum L. 53.1 Daiiciis Caroia 27.2 Rubus Allegheniensis 56.7 Dirca palustris 1OO.O Rubus idealis 89.0 Echinacea purpurea 22.9 Rumex crispiis inne 65.2 Equisetum hyemale 1OO.O Salvia elegens 32.6 Erigeron Canadensis 73.3 Salvia memorosa 26.2 Erigeron speciosus (Lindl.) D.C. 22.9 Salvia officianalis 26.3 Erica vesicaria 29.2 Saivia Sciarea S1.6 Erysimum perofskianum Fish. S. 89.8 Saivia Sciarea 21.5 Fenouil bronze 23.7 Saponaria officinalis 68.5 Filipendula rubra 93.2 Satureia montana 47.6 Filipendula rubra 1OO.O Scorzonera hispanica 29.9 Filipendula ulmaria 2O.S Sesamun indicum 84.8 Filipendula vulgaris 26.2 Soianum duticamara 51.3 Forsythia intermedia 1OO.O Solidago Canadensis 95.3 Forsythia X intermedia 1OO.O Solidago hybrida 94.5 Gaium odoratum 21.0 Solidago hybrida 99.5 Gaultheria hispidula (L.) Muhl 39.3 Solidago sp? 60.9 Gaultheria procumbens 43.4 Stellaria graminea inne 40.2 Geum rivate 21.7 Tamarindus indica 59.2 Glycine max 642 Taraxacum officinale 88.6 Glycyrrhiza glabra 53.4 Thalictrum aquilegiifolium 65.2 Hamamelis virginiana 88.4 Thalictrum Aquilegiifolium 44.5 Heliotropium arborescens 23.0 Thuja occidentalis SO.6 Huntilus lupulus 1OO.O Thymus praecox. Subsp. arctiitis 23.9 Huntilus lupulus 90.2 Tiareiia 34.4 Hydrastis Canadensis 30.9 US 2009/0263516 A1 Oct. 22, 2009 48

TABLE 5-continued TABLE 5-continued

Cath B Cath B Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Hylotelephium G R 43.8 Aium tuberosum O 26.6 Hypericum hennyi G R S.O.3 Aium tuberosum O 33.1 Iberis sempervirens G O 87.7 Aium tuberosum O 72.3 Lathyrus Saivais G R 25.9 Aium tuberosum R 22.6 Ligularia dentata G O 31.5 Aium victoriais O 423 Linaria annia G O 59.7 Alpinia oficinari in O 57.4 Lythrum salicaire G R 33.1 Alpinia oficinari in R 88.9 Melissa officinalis G O 27.6 Aithacea officinalis O 51.5 Miscanthus saccharifiorus G O 30.7 Althaea officiana is O 25.2 Nicotiana rustica G O 54.8 Amelianchier Canadensis O 20.8 Nicotiana tabacum G O 36.2 Amelianchier Canadensis R 42.1 Nigella Saiiva G O 40.3 Ansonia tabernaemontana O 30.2 Origan G O 98.8 Ananas Conostis R 36.2 Origantin majorana G O 48.9 Anaphalis margaritacea R 33.9 Panax quinquefolius L. G O 21.1 Angelica dahirica R 40.7 Panicum miliaceum G R 1OO.O Angelica Sinensis syn, A. polymorpha O 91.0 Passiflora caerula G O 66.2 Anthriscus cerefolium R 23.3 Petroselinum crispum G O 6S.O Anthriscus cerefolium O 21.7 Phaseolus vulgaris G R 40.3 Aralia Cordata R 44.1 Physostegia virginiana G O 74.O Aronia melanocarpa R 33.1 Phytolacca americana G O 1OO.O Aronia melanocarpa R 1OO.O Plantago major G O 60.9 Aronia melanocarpa (Michx.) Eil. R 3S.O Plectranthus fruticosus G O 29.2 Aronia prunifolia R SO.4 Polygonum aviculare inne G R 45.6 Artemisia draculus O 42.5 Pongania pinnata G O 41.7 Asartin europaeum O 39.4 Pulmonaria officinalis G O 36.9 Asclepias incarnata L. O 48.7 Pulmonaria saccharata G O 24.7 Asclepias tuberosa O 21.5 Raphantis sativits G O 38.9 Asciinidia chinensis O 24.9 Raphanus sativus G O 86.4 Atriplex hortensis O 22.4 Rhus aromatica G O 49.1 Atropa belladonna O 94.1 Ribes nigrum L. G O 20.6 Aubepine, hawthorne R 72.7 Rubus idealis G R 56.9 Begonia convolvulacea O 32.1 Rubus occidentais G R 61.3 Begonia emini O 40.4 Saponaria officinalis G O 48.3 Begonia glabra O 84.3 Sarrietie vivace G O 44.6 Begonia mani O 642 Satureia repandra G O 72.3 Berberus vulgaris O 35.4 Sesamun indicum G O 46.8 Beta vulgaris O 34.1 Sidaicea G O 55.2 Beta vulgaris R 86.7 Silene vulgaris G O 35.5 Beta vulgaris O 23.8 Soianum duticamara G O 56.9 Beta vulgaris R 79.4 Solidago Canadensis G O 99.8 Beta vulgaris O 34.2 Solidago Canadensis G O 1OO.O Beta vulgaris R 20.8 Solidago-sp? G O 71.8 Beta vulgaris R 37.0 Sorghum cafiorum G O 34.5 Beta vulgaris spp. Maritina R 83.6 Tamarindus indica G O 65.4 Betula glanditiosa R 62.5 Taraxacum officinale G O 82.7 Borago officinalis O 23.5 taraxacum officinale G O 42.7 Brassica Naptis O 27.6 Tetradenia riparia G O 32.5 Brassica oleracea O 21.8 Thalictrum aquilegiifolium G O 62.1 Brassica oleracea O 22.3 Thuja occidentalis G O 57.7 Button is timbellatus O 20.8 Thymus vulgaris "Argenteus." G O 40.7 Canna eduis R 1OO.O Tiareiia G R 39.0 cannellie R 99.5 Tropaeoluim maints G O 36.6 Carica papaya R 1OO.O Thissilago farfara G O 26.8 Chrysanthemum balsamita O 89.3 Vaccinium anglisiifolium G R 26.4 Chrysanthemum parthenium R 44.6 Vaccinium anglisiifolium G R 89.1 chrysanthemun coronarium (Chip Suey) O 28.7 Vaccinum macrocarpon G R 33.9 chrysanthemun coronarium (Chip Suey) O 59.2 Vitia sp. G R 1OO.O Citrus paradisi R 1OO.O Vitia sp. G R 90.9 Citrus Sinensis R 1OO.O Vitis sp. G O 37.1 Cocos nucifera R 1OO.O Achillea millefolium T O 44.1 Cocos nucifera O 71.9 Aconium napelius T O 27.4 Convailaria maialis O 67.1 Aescuit is hippocastantin T R 84.2 Corchorus oitorius R 26.0 Aescuit is hippocastantin T O 47.3 Crataegus Sanguinea O 33.1 Alcea rosea “Nigra T O 24.3 Cryptotaenia Canadensis R 23.1 Aichemia nois T R 24.9 Clictimis anguria O 26.4 Allium ascalonictim T O 31.1 Cucumissativus (Fanfare) O 25.7 Allium cepa gr. Cepa T O 39.4 Cydonia oblonga R 23.6 Allium cepa gr. Cepa T R 23.2 Daitira Stranonium O 61.4 Allium cepa gr. Cepa T O 45.5 Daiiciis Caroia R 21.1 Allium fistulost in T O 21.9 Diospiros Kaki R 1OO.O Allium grande T O 39.5 Echinacea purpurea O 27.8 US 2009/0263516 A1 Oct. 22, 2009 49

TABLE 5-continued TABLE 5-continued

Cath B Cath B Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Eriobotrya japonica 25.2 Rubus idaeus L. 42.7 Erica vesicaria 34.5 Rubus idealis 74.2 Erysimum perofskianum Fish. S. 91.O Rubus occidenia is 68.1 Fragaria Xananassa 37.5 Rumex crispiis inne 37.9 Fictis vesiculosis 87.1 Salvia memorosa 38.2 Fumaria officinalis 44.4 Sambucus Canadensis 27.5 Gaultheria procumbens 74.8 Sambucus nigra 30.8 Gentiana macrophylla 44.5 Sanguisorba minor 78.3 Glyceria maxima 37.6 Saponaria officinalis 68.7 Glycine max Envy 40.3 Saponaria officinalis L. 44.2 Glycyrrhiza glabra 37.7 Satureia hortensis 62.1 Hamamelis virginiana 78.3 Sechium edule 34.4 Helichrysum angustifolium 21.8 Sesamun indicum 78.6 Heliotropium arborescens 26.8 Sidaicea 42.9 Huntilus lupulus 84.7 Silene vulgaris 51.3 Huntilus lupulus 39.2 Solidago hybrida 92.8 Huntilus lupulus 1OO.O Solidago Hybrida 1OO.O Huntilus lupulus 1OO.O Solidago Hybrida 1OO.O Hydrastis Canadensis 42.7 Solidago sp? 39.6 Hypericum hennyi 51.8 Tamarindus indica 642 Hyperictim perforatin 52.3 Tanacetum baisania 1OO.O Hypomyces lactiflorum 30.1 Tanacetum vulgare 23.3 Iberis sempervirens 90.8 Taraxacum officinale 90.9 Jeffersonia diphylla 43.0 Taraxacum officinale (Red ribe) 34.5 Jugians nigra 66.7 Thuja occidentalis 37.6 Kochia scoparia (L.) Schrad. 38.4 Thymus serpyllum 20.6 Krameria Triandra 63.6 Tiareiia 35.6 Lentinus edodes 1OO.O Tragopogon sp. 21.1 Lentinus edodes 26.2 Trigonella foenum graecum 97.3 Ligularia dentata 34.9 Tropaeoluim maints 58.8 Lightstrum vulgare 29.5 Tropaeoluim maints 28.6 Linaria annia 72.3 Tropaeoluim maints 36.7 Linaria annia S1.1 Tsiiga diversifolia 64.O Lupinus polyphyllis indi. 47.4 Vaccinium anglisiifolium 72.2 Lychnis chalcedonica 34.4 Vaccinium anglisiifolium 50.7 Lythrum salicaire 53.8 Vaccinium macrocarpon S2.6 Mangifera indica 1OO.O Vitia sp. 35.1 Mangifera indica 29.3 98.9 26.1 Vitia sp. Nigella Saiiva 32.6 73.6 Vitis sp. N 25.4 Weigela coracensis 24.6 N 24.6 Zea mayS 1OO.O N 49.8 Zea mayS 48.1 N 43.6 N 28.4 Optainia sp. 1OO.O Panax quinquefolius L. 27.4 TABLE 6 Passiflora caerula 39.8 Pastinaca Saiiva 2O.S Cath D Perroselinum crispum 60.9 Phaseolus vulgaris 37.5 Nomlatin Stress Extrait Inhibition (%) Physostegia virginiana 642 Phytolacca americana S1.9 Agastache foeniculum 91.6 Phytolacca americana 1OO.O Agropyron cristatum 24.5 Plectranthus fruticosus 23.4 Agropyron repens 75.2 Polygonaium odoratin 1OO.O Agrostis Stofonifera 94.7 Polygonium chinense 33.6 Aichemia nois 39.0 Poniederia cordata 26.2 Aium sativum 1OO.O Portuiacea oierracea 20.7 Allium Schoenoprastin 40.O Primuia veris 58.2 Althaea officinalis 96.5 Prunus persica 1OO.O Amaranthus gangeticits 67.4 Prunus persica (hybrids de la peche) 1OO.O Amaranthus gangeticits 74.3 Pulmonaria officinalis 22.8 Amaranthus retroflexus 1OO.O Punica granatin 1OO.O Ambrosia artemisiifolia 75.4 Pyrus pyrifolia 22.4 Anethlin graveolens 48.7 Radix Paeonia rubra 39.8 Angelica archangelica 27.6 Rahmni is fianguia 25.3 Anthemis nobiis 56.2 Raphantis sativits 45.8 Anthemistinctoria 423 Rhus trilobata 2O2 Aralia Cordata 1OO.O Ribes tiva-crispa 34.2 Aralia nudicatiis 44.9 Rosa Rugosa "Alba" 45.4 Arctii in minus 93.2 Rubus idaeus 31.2 Arctii in minus 1OO.O US 2009/0263516 A1 Oct. 22, 2009 50

TABLE 6-continued TABLE 6-continued

Cath D Cath D

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Aronia melanocarpa A. O 22.8 Gaultheria hispidula A. R 71.9 Artemisia abroianum A. O 31.3 Gaultheria hispidula A. O 90.2 Artemisia abroianum A. O 43.6 Gentiana lutea A. R 1OO.O Artemisia absinthium A. O 58.3 Giechona hederacea A. O 32.7 Artemisia Absinthium A. O 71.4 Glycine max A. S 55.1 Artemisia dracunculus A. O 70.5 Glycine max A. R 1OO.O Artemisis Ludoviciana A. O 74.4 Glycyrrhiza glabra A. R 1OO.O Artemisis Ludoviciana A. O 1OO.O Guizotia abyssinica A. O 73.8 Asparagus officinalis A. O 61.9 Hedeona ptilegioides A. O 1OO.O Aster sp A. O 1OO.O Heianthus tuberosus A. O 37.2 Aster sp A. O 1OO.O Hordeum hexastichon A. R 34.6 Atropa belladonna A. O 1OO.O Hordeum hexastichon A. O 63.6 Beckmannia eruciformis A. R 22.1 Hordeum vulgare A. O 66.7 Beckmannia eruciformis A. O 48.3 Hordeum vulgure subsp. Vulgare A. O 33.3 Beta vulgaris A. R 21.2 Hypericum hennyi A. O 66.7 Beta vulgaris A. R 1OO.O Hyssopus officinalis A. O 1OO.O Beta vulgaris spp. Maritina A. O 30.8 Ipomoea Batatas A. O 55.1 Betta vulgaris A. O 1OO.O Iris versicolor A. R 24.1 Brassica naptis A. R 63.6 Iris versicolor A. O 30.8 Brassica oleracea A. R 33.3 Lathyrus Saivais A. O 20.6 Brassica rapa A. R 23.8 Latiri is nobilis A. O 33.3 Brassica rapa A. O 26.1 Levisticum officinale A. O 87.6 Bronts inermis A. O 59.6 Lintin itsitatissini in A. R 21.4 Calamintha nepeta A. R 24.O Lintin itsitatissini in A. O 44.4 Campaniiia raptinctius A. O 41.6 Lolium perenne A. O 30.9 Canna eduis A. O 1OO.O Lotus corniculatus A. O 23.4 Capsella bursa-pastoris A. O 36.7 Lycopersicon escientiin A. R 40.O Capsicum annittin A. R 25.8 Matricaria recitita A. S 56.4 Capsicum annuum A. R 28.2 Medicago Saiiva A. R 2O.S Capsicum annittin A. O 64.7 Melissa officinalis A. O 1OO.O Capsicum annittin A. R 76.9 Mentha piperita A. O 22.7 Capsicum finitescens A. O 44.1 Mentha piperita A. R 1OO.O Carthamus tinctorius A. O 42.9 Mentha suaveolens A. O 53.2 Cartin carvi A. R 28.6 Nepeta Cataria A. O 1OO.O Chaerophyllum bulbosom A. O 1OO.O Nicotiana tabacum A. O 37.7 Chelidonium maius A. R 1OO.O Nicotiana tabacum A. R 44.3 Chenopodium bonus-henrict is A. O S4.3 Oenothera biennis A. O 23.8 Chenopodium quinoa A. R 22.2 Oenothera biennis A. O 40.O Chrysanthemum coronarium A. O 96.8 Oenothera biennis A. R 1OO.O Cichorium endivia susp. Endivia A. R 36.0 Origantim vulgare A. O 94.7 Cichorium endivia susp. Endivia A. O 78.4 Panax quinquefoils A. O 29.8 Cichorium intybus A. O 1OO.O Panax quinquefoils A. O 35.1 Citritius ianatus A. O 22.7 Panax quinquefoils A. O 40.4 Citritius ianatus A. R 26.7 Pastinaca Saiiva A. O 744 Citritius ianatus A. R 35.9 Perilla frutescens A. O 86.7 Citritius ianatus A. O 76.5 Perilla frutescens A. R 1OO.O Coix Lacryma-Jobi A. O 20.9 Petasitesiaponicus A. O 43.5 Coix Lacryma-Jobi A. O 93.2 Petroselinum crispum A. O 1OO.O Cornus Canadensis A. O 30.9 Phaiaris arundinacea A. O 21.3 Cuburbitapepo A. O 21.9 Phaiaris canariensis A. O 22.0 Cucumis meio A. O 44.1 Phaseolus coccineus A. O 68.8 Ciclinissativits A. O 21.3 Phaseolus mingo A. S 58.5 Ciclinissativits A. R 33.3 Phaseolus mingo A. O 1OO.O Cucurbita Maxina A. R 1OO.O Phaseolus vulgaris A. O 33.3 Cucurbita moschata A. R 2O.S Phaseolus vulgaris A. O 80.3 Cucurbitapepo A. O 31.9 Phleum pratense A. O 2O2 Cucurbitapepo A. R 40.9 Physalis ixocarpa A. R 1OO.O Cucurbitapepo A. O 41.2 Pimpinella anisum A. O 86.7 Curcuna Zedoaria A. O 26.3 Plantago major A. O 99.0 Cymbopogon martini A. O 77.8 Plectranthus sp. A. R SO.O Daiiciis Caroia A. O 55.1 Plectranthus sp. A. O 64.O Daiiciis Caroia A. R 1OO.O Polygonum aviculare A. O 55.7 Dipsactis Saivais A. O 21.1 Poterium sanguisorba A. R 1OO.O Elymaisincetts A. O 27.7 Poterium Sanquisorba A. O 23.4 Eschscholzia Californica A. O 44.4 Prunus Tomentosa A. O 27.6 Foeniculum vulgare A. O 81.8 Raphantis Saivais A. O 36.8 Forsythia intermedia A. O 40.4 Raphantis sativits A. R 1OO.O Forsythia intermedia A. R 1OO.O Rheun rhabarbarium A. R 33.0 Fragaria xananassa A. R 38.5 Ribes nigrum A. R 21.1 Gainsoga ciliata A. O 46.7 Ribes nigrum A. O 32.6 Gaium odoratum A. O 21.6 Ribes rubrum A. O 24.5 Gaium odoratum A. R 22.7 Ribes Sylvestre A. O 21.1 US 2009/0263516 A1 Oct. 22, 2009 51

TABLE 6-continued TABLE 6-continued

Cath D Cath D

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Ribes Sylvestre A. R 30.3 Agropyron repens G O 93.3 Rosa rugosa A. R 21.1 Aichemia nois G O 32.1 Rosa rugosa A. O 36.6 Allium ascalonictim G O 29.7 Rosa rugosa A. O 40.2 Aium sativum G R 1OO.O Rosmarinus officinalis A. O 95.7 Allium Schoenoprastin G R 1OO.O Rubus Canadensis A. R 25.8 Aium tuberosum G R 1OO.O Rubus Canadensis A. O 31.7 Althaea officinalis G O 95.6 Rubus idaeus A. O 85.9 Amaranthus caudathus G O 95.3 Rubus idealis A. R 66.7 Amaranthus gangeticits G O 45.7 Rumex acetoseiia A. O 27.4 Amaranthus retroflexus G O 78.3 Rumex crispiis A. O 2S.O Ambrosia arternisiifolia G O 73.8 Rumex Scittatus A. O 21.3 Amelanchier alnifolius G O 50.5 Salvia officinalis A. O 21.3 Anethlin graveofens G O 1OO.O Salvia officinalis A. O 85.1 Anthemis nobiis G O 94.3 Salvia officinalis A. R 1OO.O Apium graveolens G O 21.9 Saivia Sciarea A. O 29.9 Arctii in minus G O 65.9 Sanguisorba officinalis A. O 23.1 Arctii in minus G O 71.7 Sanguisorba officinalis A. R 48.3 Arctostaphylos tiva-lisi G O 84.8 Santolina Chamaecyparissus A. O S2.9 Aronia melanocarpa G O 31.5 Satureia montana A. O 87.4 Arrhenaiherum eiatius G S SO.8 Scorzonera hispanica A. O 30.8 Artemisia abroianum G O S2.1 Secale cereale A. R 21.2 Artemisia absinthium G O 59.7 Senecio vulgaris A. O 42.6 Artemisia absinthium G O 72.9 Sesamun indicum A. O 27.3 Artemisia Ludoviciana G O 64.1 Silybum marianum A. O 25.2 Artemisia Ludoviciana G O 90.7 Siim Sisartin A. O 34.4 Artemisia vulgaris G O 55.2 Soianum duticamara A. R 21.4 Artemisia vulgaris G O 83.3 Soianum melanocerastin A. S 44.6 Asclepias incarnata G O 38.9 Soianum melanocerastin A. R 60.0 Asclepias incarnata G O 75.6 Soianum tuberosum A. O 29.2 Asparagus officinalis G R 27.8 Solidago sp A. O 98.4 Aster sp G O 33.3 Spinacia oleracea A. O 40.5 Atropa belladonna G O 96.6 Spinacia oleracea A. S 57.7 Beta vulgaris G O 92.1 Stachys affinis A. O 23.8 Beta vulgaris G R 1OO.O Stachys byzantina A. O 96.1 Beta vulgaris spp. Maritina G R 1OO.O Stellaria graminea A. O 34.4 Borago officinalis G O 1OO.O Steiaria media A. O 24.6 Brassica naptis G R 40.9 Symphytum officinale A. O 87.7 Brassica oleracea G R 66.7 Symphytum officinale A. O OO.O Bronts inermis G O 38.3 Tanacetum cinerariifolium A. O 70.7 Calamintha nepeta G R 25.3 Tanacetain parthenium A. R 40.O Campaniiia raptinctius G S SO.8 Tanacetain parthenium A. O 74.7 Campaniiia raptinctius G O 68.8 Tanacetain parthenium A. R OO.O Campaniiia raptinctius G O 69.9 Tanacetum vulgare A. O 26.7 Canna eduis G S SO.8 Tanacetum vulgare A. R 32.7 Capsella bursa-pastoris G O 3O.O Tanacetum vulgare A. O 98.4 Capsicum annium G O 27.9 Tanacetum vulgare A. O OO.O Capsicum annium G R 33.3 Taraxacum officinale A. R 22.7 Capsicum annium G R 35.9 Taraxacum officinale A. O OO.O Capsicum annium G R 41.O Teucrium chamaedrys A. O OO.O Capsicum annium G S 43.1 Thymus praecox. Subsp. arcticus A. O 75.6 Capsicum annium G O 56.9 Thymus praecox. Subsp. arcticus A. O OO.O Capsicum finitescens G O 60.8 Thymus serpyllum A. O 78.1 Carthamus tinctorius G O 30.2 Thymus vulgaris A. O 90.9 Cartin carvi G O 28.6 Trichosanthes kirillowii A. O OO.O Chaerophyllum bulbosum G O 88.9 Trifolium incarnatum A. S 76.9 Chrysanthemum coronarium G O 82.5 Trifolium pannonicum A. O 72.6 Cicer arrieintin G R 31.8 Trifolium pratense A. O OO.O Cichorium endivia subspendivia G O 1OO.O Trifolium repens A. O OO.O Cichorium intybus G O 1OO.O Triticum durum A. R 22.7 Circium arvense G S 53.8 Triticum spelta A. R 24.O Circium arvense G O 6.3.3 Triticum spelta A. O 32.4 Citritius ianatus G O 40.9 Typha latifolia A. O S2.1 Citritius ianatus G O 56.9 Vaccinium Corymbosum A. R 53.3 Coix Lacryma-Jobi G O 1OO.O Vaccinium macrocarpon A. R 44.3 Cornus Canadensis G O 2O2 Valefiana officinalis A. O 23.1 Cornus Canadensis G O 35.1 Verbascum thapsus A. O 65.6 Clictimis anguria G R 40.O Vitis sp. A. O 33.7 Cucurbita maxima G O 31.4 Vitis sp. A. R 93.3 Cucurbita maxima G R 40.9 Zea mays A. R 2S.O Cucurbita moschata G O 23.0 Zea mays A. R SO.O Cucurbita moschata G R 31.8 Achillea millefolium G O 47.7 Cucurbita moschata G S 47.7 US 2009/0263516 A1 Oct. 22, 2009 52

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Cucurbitapepo 29.8 Phaseolus mingo OO.O Cucurbitapepo 53.3 Phaseolus vulgaris 54.8 Cymbopogon martini 1OO.O Phaseolus vulgaris 67.2 Cynara Scolymis 27.3 Plantago major 95.2 Datura meiei 54.1 Plectranthus sp. OO.O Daiiciis Caroia 28.6 Plectranthus sp. OO.O Daiiciis Caroia 1OO.O Poa compressa 2O2 Digitalis purpurea 1OO.O Portuiaca oierracera 6O.O Dirca palustris 24.5 Potentiiia anserina OO.O Elymaisincetts 38.3 Poterium sanguisorba 21.3 Erigeron speciosus 73.7 Poterium sanguisorba OO.O Foeniculum vulgare 1OO.O Prunella vulgaris 70.3 Forsythia intermedia 1OO.O Raphantis Raphanistrain 33.3 Forsythia x intermedia 42.1 Raphantis Raphanistrain 80.0 Gaium odoratum 63.6 Raphantis sativits S2.6 Gaium odoratum 64.7 Raphantis sativits OO.O Gaultheria hispidula 63.4 Ribes nigrum 42.1 Gaultheria hispidula 69.6 Ribes Sylvestre 32.O Giechona hederacea 50.5 Ricinits communis OO.O Giechona hederacea 1OO.O Rosa rugosa 52.4 Glycine max 27.9 Rosa rugosa 90.2 Glycine max 1OO.O Rosmarinus officinalis OO.O Guizotia abyssinica 33.3 Rubus idealis 34.8 Guizotia abyssinica 83.6 Rubus occidenia is 6O.O Helianthus annuit is 1OO.O Rubus occidenia is 65.3 Heianthus strumosus 28.9 Rumex crispiis 43.3 Heianthus strumosus 52.2 Rita graveolens 23.0 Heianthus tuberosus 29.3 Salvia officinalis 1OO.O Heianthus tuberosus S4.9 Salvia officinalis 1OO.O Helichrysum thianschanicum 3O.S Sambucus Canadensis 80.6 Heliotropium arborescens 29.1 Sambucus ebulus 21.1 Hysopus officinalis 1OO.O Sambucus ebulus 36.8 Ipomoea batatas 45.8 Sanguisorba officinalis 43.6 Lactica Saiiva 26.6 Santolina Chamaecyparissils SO.6 Lathyrus Saivais 72.7 Saponaria officinalis 85.6 Lathyrus Sylvestris 33.3 Satureia hortensis 36.8 Lathyrus Sylvestris 56.8 Satureia hortensis 68.4 Lavandhiia anguistifolia 1OO.O Senecio vulgaris 31.1 Lavandhiia anguistifolia 1OO.O Sesamun indicum 27.3 Lavandhiia iaiifolia 1OO.O Siim Sisartin 20.8 Leonirits cardiaca 1OO.O Siim Sisartin 47.8 Levisticum officinale 98.1 Soianum melanocerastin 23.5 Levisticum officinale 1OO.O Soianum melongens 28.6 Lintin itsitatissini in 42.9 Soianum melongens 41.2 Lolium perenne 25.5 Solidago Sp 72.1 Lotus tetragonolobits 49.2 Sonchi is oleracetis 95.1 Lupinus polyphyllius 33.3 Stachys Afinis 38.1 Lycopersicon escientiin 29.5 Stachys byzantina 28.6 Lycopersicon escientiin 43.3 Stellariagraminea 39.3 Lycopersicon pinpineliifolium 1OO.O Steiaria media 21.3 Maiva moschata 1OO.O Symphytum officinale 37.8 Medicago Saiiva 32.6 Symphytum officinale 43.1 Melissa officinalis 1OO.O Symphytum officinale 92.6 Mentha piperita 40.3 Symphytum officinale 1OO.O Mentha suaveolens 79.2 Tanacetum cinerariifolium 91.3 Monarda didyma 1OO.O Tanacetain parthenium 6O.O Nepeta Cataria 1OO.O Tanacetain parthenium 86.7 Ocimum basilicum 8O.S Tanacetum vulgare 44.4 Oenothera biennis 41.7 Tanacetum vulgare 67.9 Oenothera biennis 1OO.O Tanacetum vulgare 85.7 Origantin majorana 67.4 taraxacum officinale 40.9 Origantim vulgare 1OO.O taraxacum officinale 1OO.O Oxalis Deppei 22.2 Teucrium chamaedrys 33.3 Oxalis Deppei 44.6 Teucrium chamaedrys 66.7 Oxyria digyna 21.3 Thymus fragantissinus 24.1 Panax quinquefolius 25.5 Thymus praecox. Subsp. arcticus 2S.O Panax quinquefolius 38.3 Thymus praecox. Subsp. arcticus 92.7 Panicum miliaceum 83.3 Thymus praecox. Subsp. arcticus 1OO.O Pennisetum alopectiroides 21.5 Thymus serpyllum 1OO.O Petasitesiaponicus 40.6 Thymus vulgaris 64.4 Petroselinum crispum 1OO.O Thymus x citriodorus 72.7 Peucedanum cervaria 42.9 Tiarella cordifolia 92.4 US 2009/0263516 A1 Oct. 22, 2009 53

TABLE 6-continued TABLE 6-continued

Cath D Cath D

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Trifolium hybridum G O 29.5 Capsella bursa-pastoris O 21.7 Trifolium pannonicum G O 54.7 Capsicum annuin O 46.1 Trifolium pratense G O 92.9 Capsicum annium R 2O.S Trifolium repens G O 1OO.O Capsicum annium O 23.3 Triticum spelta G R 37.3 Capsicum annium R 41.O Triticum turgidium G O 59.5 Capsicum finitescens O 58.8 Typha latifolia G O 23.4 Carthamus tinctorius O 36.5 Vaccinium corymbosum G O 26.5 Cartin carvi O 88.6 Vaccini in anglisiifolium G O 27.7 Chaerophyllum bulbosum O 2S.O Vaccinum macrocarpon G R 33.0 Chaerophyllum bulbosum O 95.2 Valeriana officinalis G R 27.6 Chelidonium maius O 27.1 Valeriana officinalis G O 51.3 Chelidonium maius R SO.O Verbascum thapsus G O 21.3 Chenopodium bonus-henricus O 6O.O Vinca minor G O 28.6 Chenopodium quinoa R 31.5 Vitis sp. G R 40.O Chenopodium quinoa O SO.O Vitis sp. G O 42.6 Chrysanthemum coronarium R 65.5 Zea mays G R 26.9 Chrysanthemum coronarium O 1OO.O Zea mays G R 1OO.O Cicer arrieintin R 27.3 Abies lasiocarpa O 25.6 Cichorium endivia subspendivia R 27.3 Agastache foeniculum O 1OO.O Cichorium endivia subspendivia O 97.3 Agropyron cristatum O 2O2 Cichorium intybus O 1OO.O Agrostis alba O 24.5 Clinicifiiga racemosa R 22.2 Aichemia nois O 33.3 Circium arvense O 78.3 Aichemia nois S 49.2 Citritius ianatus R 26.7 Aichemia nois O 66.2 Citritius ianatus O 45.5 Allium ampeioprastin O 1OO.O Citritius ianatus O 62.7 Allium ascalonictim O 29.7 Coix Lacryma-Jobi O 77.3 Allium ascalonictim R 38.7 Coriandrum sativum O 90.0 Allium cepa R 1OO.O Cornus Canadensis O 29.3 Aium tuberosum R 1OO.O Clictimis anguria R SO.O Alpinia officinarum R SO.O Clictimis anguria O 70.1 Althaea officinalis O 58.6 Cucumis meio R 2O.S Amaranthus candaihits R 22.9 Cucumis meio O S1.0 Amaranthus candatiis O 93.2 Ciclinissativits O 23.4 Amaranthus caudathus O 1OO.O Cucurbita maxima O SO.O Amaranthus gangeticits O 57.1 Cucurbita moschata O 84.9 Amaranthus retroflexus O 1OO.O Cucurbitapepo R 2O.S Ambrosia artemisiifolia O 86.9 Cucurbitapepo O 39.2 Amelanchier alnifolia O 50.5 Cucurbitapepo S 53.8 Anthemis nobilis O 1OO.O Curcuna Zedoaria O 24.6 Anthriscus cerefolium O 1OO.O Cymbopogon citratus O 1OO.O Aralia Cordata R 1OO.O Cynara Scolymis R 33.3 Arctii in minus O 68.3 Dactiis Giomerata O 2O2 Aronia melanocarpa O SO.O Datura meiei O 37.8 Aronia prunifolia O 44.7 Daitira Stranonium R SO.O Arrhenaiherineiatius O 78.7 Daiiciis Caroia R 21.1 Artemisia absinthium O 58.4 Daiiciis Caroia O 30.3 Artemisia dracunculus R 28.6 Daiiciis Caroia O 49.3 Artemisia dracunculus O 86.3 Daiiciis Caroia S 52.3 Artemisia Ludoviciana O 48.8 Dipsactis sativus O 73.7 Artemisia vulgaris O SO.O Dirca palustris O 88.5 Artemisia vulgaris O 82.8 Eleusine Coracana S 49.2 Asclepias incarnata O 72.9 Elymaisincetts O 35.1 Asparagus officinalis O 69.8 Erigeron speciosus O 67.8 Aster sp O 3S.O Fagopyrim esculenium O 27.3 Avena Saiiva O 31.8 Foeniculum vulgare R 80.0 Baptisia tinctoria O 33.8 Forsythia intermedia O SO.9 Beta vulgaris O 25.5 Forsythia x intermedia O 57.9 Beta vulgaris O 28.6 Fictis vesiculosis O 83.7 Beta vulgaris R 34.6 Fictis vesiculosis R 1OO.O Beta vulgaris S 43.6 Gainsoga ciliata O 56.7 Beta vulgaris O 54.5 Galium aparine O 6O.S Beta vulgaris R 1OO.O Gaium odoratum R 31.8 Beta vulgaris spp. Maritina R 1OO.O Gaultheria hispidula O 33.7 Brassica nigra R 45.5 Gaultheria procumbens O 2S.O Brassica oleracea O SO.O Gentiana lutea O 98.1 Brassica oleracea R 1OO.O Gentiana macrophylla O 1OO.O Bronts inermis O 30.9 Giechona hederacea O 62.6 Calamagrostis artindiflora O 85.6 Glycine max O 26.2 Calendula officinalis O 23.7 Glycyrrhiza glabra R SO.O Campaniiia raptinctius O 2S.O Glycyrrhiza glabra S 51.3 Canna eduis O 26.3 Guizotia abyssinica O 39.3 US 2009/0263516 A1 Oct. 22, 2009 54

TABLE 6-continued TABLE 6-continued

Cath D Cath D Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Guizotia abyssinica 1OO.O Phaseolus vulgaris Hedeona ptilegioides 1OO.O Phaseolus vulgaris Heianthus annus 75.8 Physalis ixocarpa 25.5 Heianthus strumosus 55.6 Pimpinella anisum 1OO.O Heianthus tuberosus 22.1 Pimpinella anisum 1OO.O Helichrysum angustifolium 96.1 Pistin Saivain 37.5 Helichrysum thianschanicum 70.5 Plantago major 1OO.O Heliotropium arborescens 83.2 Plectranthus sp. 36.0 Helleborus niger 24.1 Plectranthus sp. 80.0 Herba Schizonepetae 6O.S Poa pratensis 38.3 Hibiscus cannabinus S2.6 Popitius Xpetrovskyana 25.5 Hordeum vulgare 77.8 Prunella vulgaris 23.3 Hydrastis Canadensis 64.9 Prunella vulgaris 88.1 Hypericum hennyi OO.O Raphantis raphanistrain 73.7 Hyperictim perforatin 31.0 Raphantis raphanistrain OO.O Hyssopus officinalis OO.O Raphantis sativits 60.3 Initia heienium OO.O Raphantis sativits OO.O Ipomoea bataias 91.5 Reseda luteola OO.O Iris versicolor 35.9 Rheum officinale 36.8 Juniperus communis 83.8 Ribes sativum 20.4 Krameria Triandra 25.6 Ribes Sylvestre 44.3 Lactica Saiiva OO.O Ricinits communis OO.O Lathyrus Saiivus 27.3 Rosmarinus officinalis 6O.O Lathyrus Saiivus 33.3 Rosmarinus officinalis OO.O Lathyrus Sylvestris 20.3 Rubus Canadensis 32.O Lathyrus Sylvestris OO.O Rubus Canadensis 34.7 Latiri is nobilis 23.8 Rubus idaeus 93.5 Latiri is nobilis 26.O Rubus idealis OO.O Lavandula laiifolia OO.O Rubus occidenia is 38.6 Lavandhiia iaiifolia OO.O Rubus occidenia is 52.3 Lens citiinaris Subsp culinaris 21.3 Rubus occidenia is OO.O Leonori is cardiaca 57.9 Rumex acetoseiia 26.3 Lepidium sativum 31.6 Rumex crispiis 3O.O Levisticum officinale 90.5 Rumex Scittatus 23.0 Levisticum officinale 1OO.O Rita graveolens 62.1 Lintin itsitatissini in 23.8 Saccharum officinarum 27.0 Lonicera syringantha 79.5 Salvia officinalis 92.0 Lotus Coliniculatus 46.7 Salvia officinalis 93.3 Lupinus polyphyllis indi. 36.6 Sambucus Canadensis 42.9 Lycopersicon escientiin 60.0 Sanguisorba officinalis 68.6 Maius hupehensis 1OO.O Santolina Chamaecyparissils 66.7 Malva Sylvestris 1OO.O Saponaria officinalis 36.6 Matricaria spp. 1OO.O Saponaria officinalis 84.7 Medicago Saiiva 27.7 Satureia montana 8O.S Melissa officinalis 1OO.O Satureia repandra 47.1 Menyanthes trifoliata 44.9 Senecio vulgaris 44.3 Menyanthes trifoliata SO.O Setaria itaica 27.9 Miscanthus sinensis 23.5 Silybum marianum 31.0 Miscanthus sinensis 24.6 Siim Sisartin 24.8 Nepeta Cataria 78.9 Siim Sisartin 25.5 Ocimum Basilicum 35.7 Soianum duticamara 21.4 Ocimum Basilicum 1OO.O Soianum melongena 25.8 Oenothera biennis 1OO.O Soianum melongena 34.9 Origantim vulgare 94.7 Soianum tuberosum 38.1 Origantim vulgare 1OO.O Solidago Canadensis 1OO.O Oxalis Deppei 21.1 Solidago Sp oxyria digyna 24.6 Sonchi is oleracetis Panax quinquefolius 39.4 Sorghum durra 23.8 Panicum miliaceum 20.8 Spinacia oleracea 29.3 Pastinaca Saiiva 21.3 Stachys affinis 23.6 Pastinaca Saiiva 2S.O Stachys affinis 23.9 Pastinaca Saiiva 2S.O Stachys affinis Pastinaca Saiiva 79.4 Stachys byzantina 41.6 Pastinaca Saiiva 1OO.O Stellariagraminea 62.3 Perilla frutescens 96.O Stipa capillata 27.1 Perilla frutescens 1OO.O Symphytum officinale 28.9 Petasites Japonicus 29.0 Symphytum officinale 87.7 Petroselinum crispum 40.O Symphytum officinale 97.8 Peucedanum of easeinum 55.1 Tanacetum cinerariifolium 62.7 Pfafia paniculata 1OO.O Tanacetain parthenium 94.7 Phaseolus mingo 70.2 Tanacetum vulgare 28.9 Phaseolus vulgaris 71.4 Tanacetum vulgare 47.7 US 2009/0263516 A1 Oct. 22, 2009

TABLE 6-continued TABLE 7-continued

Cath D Cath G Nom latin Stress Extrait Inhibition (%) Inhibition Nomlatin Stress Extrait (%) Tanacetum vulgare 75.6 Tanacetum vulgare 95.2 Arctostaphylos tiva-lisi 2S.O Tanacetum vulgare 1OO.O Arctostaphylos tiva-lisi 1OO.O Taraxacum officinale 95.3 Arctostaphylos tiva-lisi 38.4 Thymus praecox. Subsp. arcticus 24.4 Aronia melanocarpa (Michx.) Ell. 24.4 Thymus praecox. Subsp. arcticus 60.0 Aronia melanocarpa (Michx.) Ell. 27.3 Thymus praecox. Subsp. arcticus 90.0 Aronia melanocarpa (Michx.) Ell. 47.8 Thymus-pseudoianuginostis 83.9 Artemisia dractinctiitis Saiiva 32.2 Thymus serpyllum 1OO.O Artemisis Ludoviciana 88.8 Tiarella cordifolia 93.3 Aster sp? 47.2 Tragopogon porrifolius 34.4 Aster sp? 1OO.O Tragopogon porrifolius 58.0 Beta vulgaris 23.9 Trichosanthes kirillowii 25.3 Brassica naptis 22.3 Trifolium pannonicum 61.1 Brassica naptis 22.8 Trifolium pratense 92.9 Brassica nigra 47.2 Trifolium repens 1OO.O Brassica rapa 46.0 Trictim aestivum 29.5 Capsella bursa-pastoris (linné) médicus 43.4 Triticum durum 1OO.O Chaerophyllum bulbosom 90.7 Triticum turgidium 29.7 Chaerophyllum bulbosom 57.4 Ulmus americana 76.9 Chenopodium bonus-henrict is 23.7 Ulmus americana 81.0 Chichorium endivia 53.0 Urtica dioica 40.9 Chrysanthemum leucanthemum linné 55.5 Vaccinium anglisiifolium 26.3 Cicer arrieintin 26.2 Vaccinium anglisiifolium 28.3 Cichorium intybus 1OO.O Vaccinium anglisiifolium 47.6 Cichorium intybus 83.6 Vaccinium anglisiifolium 1OO.O Cichorium intybus S1.O Vaccinium corymbosum 21.4 Crataegus sp? 1OO.O Vaccinium macrocarpon 80.0 Crataegus sp? 81.6 Valeriana officinalis 43.6 Cymbopogan citratus 33.9 Vicia Saiva 43.1 Datisca cannabina 2O2 Daiiciis Caroia 62.O 26.7 Vitis sp. Daiiciis Caroia 99.4 Vitis sp. 93.3 Dirca palustris 24.9 Zea mays 21.2 Dirca palustris 47.0 Zea mays 1OO.O Dryopteris filix-mas 24.1 Dryopteris filix-mas 95.7 Echinacea purpurea 80.7 Echinacea purpurea 1OO.O TABLE 7 Filipendula rubra 2O2 Filipendula rubra 77.6 Cath G Foeniculum vulgare 23.3 Fragaria Xananassa 32.3 Inhibition Fragaria Xananassa 1OO.O Nom latin Stress Extrait (%) Fragaria Xananassa 1OO.O Fragaria Xananassa 1OO.O Achillea millefolium 40.1 Frangoria Xananassa 1OO.O Achillea millefolium 29.5 Frangoria Xananassa 1OO.O Acorus calamus 68.6 Gainsoga ciliata (Rofiresque) Blake 21.2 Adiantum pedatum 29.7 Gaultheria hispidula (L.) Muhl. 85.3 Agastache foeniculum 36.8 Gaultheria hispidula (L.) Muhl. 1OO.O Agastache foeniculum 22.4 Gaultheria procumbens 56.1 Agropyron rupens 24.5 Glycine Max 36.0 Aichemia nois 1OO.O Glycine max 38.7 Aichemia nois 81.1 Glycyrrhiza glabra 46.2 Aichemia nois 51.5 Glycyrrhiza glabra 35.5 Aichemia nois 78.6 Glycyrrhiza glabra 1OO.O Aichemia nois 82.9 Hamamelis virginiana 1OO.O Aichemia nois 35.6 Heianthus tuberosus 22.6 Aikanna tinctoria S1.6 Helichrysum angustifolium 82.6 Aikanna tinctoria 1OO.O Heliotropium arborescens 57.3 Aium Tuberosum 20.6 Heliotropium arborescens 57.2 Althaea officinalis 21.6 Hordeum vulgare 34.3 Althaea officinalis 39.6 Hypericum hennyi 30.4 Ambrosia artemisiifolia linné 47.6 Hyperictim perforatin 1OO.O Ambrosia artemisiifolia linné 38.2 Initia heienium 64.O Amelanchier sanguinea (Pursh) DC. 29.7 Isais inctoria 94.O Angelica archangelica 68.1 Latiri is nobilis 49.9 Anthemistinctoria 26.O Lavenditia iaiifolia 1OO.O Anthemistinctoria 28.4 Lavenditia iaiifolia 48.7 Anthemistinctorium 46.9 Leonori is cardiaca 1OO.O Arachis hypogaea 84.5 Levisectim officinale 46.8 Aralia nudicatiis 61.9 Lolium multiflorum 34.1 US 2009/0263516 A1 Oct. 22, 2009 56

TABLE 7-continued TABLE 7-continued

Cath G Cath G

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Melissa officinalis 54.1 Saivia Sciarea 29.1 Melissa officinalis 1OO.O Santoina 65.5 Melissa officinalis 80.7 Satureia montana 72.2 Melissa officinalis 1OO.O Satureia montana 1OO.O Menthapulegitim 29.1 Satureia montana 90.5 Mentha spicaia 47.0 Satureia montana 28.9 Nepeta Cataria 57.6 Scuttellaria laterifiora 23.7 Ocrothera biennis 33.1 Sonchi is oleracetis L. 25.9 Oenothera biennis linné 47.4 Sorghum dochra bicolor 25.6 Oenothera biennis linné 1OO.O Sorghum durra (Stapif) 46.9 Origantin majorana 34.6 Symphytum officinale 99.4 Origantim vulgare 65.9 Symphytum officinale 97.8 Origantim vulgare 48.2 Tanacetum cinerarifolium 28.2 Origantim vulgare 70.O Tanacetain parthenium 34.8 Origantim vulgare 62.9 Tanacetum vulgare 80.0 Origantim vulgare 68.4 Tanacetum vulgare 53.8 Origantim vulgare 81.9 Tanacetum vulgare 35.9 Origantim vulgare 61.3 Tanacetum vulgare 68.8 Origantim vulgare 21.7 Tanacetum vulgare “Goldsticks' S1.9 Oxyria digyna 40.1 Taraxacum officinale 28.5 Perilla frutescens 6S.O Taraxacum officinale 82.3 Perilla frutescens S1.9 Thymus praecox. Subsp. arctiitis 43.4 Peucedanum cervaria 28.3 Thymus pseudoianuginostis 29.7 Peucedanum cervaria 45.1 Thymus serpyllum 1OO.O Phaseolus Vulgaris 38.4 Thymus serpyllum 73.6 Phaseolus Vulgaris 26.3 Thymus serpyllum 74.9 Phytolacca americana 27.8 Thymus vulgaris 35.6 Plantago coronopus 22.7 Thymus vulgaris 66.5 Polygonum aviculare linné 76.O Thymus vulgaris Argenteus' 73.9 Poterium sanguisorba 20.1 Triticum fungidium?? 21.6 Poterium sanguisorba 93.1 Vaccini in augustifolium 26.1 Poterium sanguisorba 47.7 Vaccinum Corymbosum 95.7 Poterium sanguisorba 36.1 Vaccinum macrocarpon 46.1 Pteridium aquilinum 25.7 Valerianeia locusta 96.O Pteridium aquilinum 1OO.O Veronica officinalis 26.4 Ribes nidigrolaria 51.8 Viburnum trilobum Marsh. 2S.O Ribes Nigrum 1OO.O Vicia Saiva 28.2 Ribes nigrum 33.6 Vicia viliosa 34.5 Ribes nigrum L. 58.8 Vitia sp. 26.O Ribes nigrum L. 21.5 Vitia sp. 41.6 Ribes Saivum 21.4 Vitia sp. 1OO.O Ricinits communis 1OO.O Vitia sp. 30.8 Rosa rugosa thunb. 20.1 Vitia sp. 22.3 Rosa rugosa thunb. 1OO.O Vitia sp. 28.5 Rosa rugosa thunb. 1OO.O Zea Mays 32.3 Rosmarinus officinalis 1OO.O Zea Mays 34.5 Rosmarinus officinalis 64.O Achillea millefolium 30.6 Rosmarinus officinalis 55.6 Achillea millefolium 71.1 Rosmarinus officinalis 76.7 Aconium napeiitis 1OO.O Rubus allegheniensis 32.1 Acorus calamus 27.8 Rubus Canadensis 94.5 Adiantum pedatum 1OO.O Rubus Canadensis 642 Agastache toeniculum “Snow Pike' 46.9 Rubus idaeus 86.0 Agastache toeniculum “Snow Pike' 71.5 Rubus idaeus 29.5 Aichemia nois 1OO.O Rubus idaeus 38.7 Aichemia nois S2.6 Rubus idaeus 410 Aichemia nois 80.7 Rubus idaeus 1OO.O Aichemia nois 33.4 Rubus idaeus L. 30.2 Aichemia nois 38.7 Rubus idaeus L. 29.4 althaea officinalis 27.5 Rubus idaeus L. 1OO.O althaea officinalis 36.9 Rubus idealis 1OO.O Ambrosia artemisiifolia linné 48.4 Rubus idealis 67.1 Ambrosia artemisiifolia linné 36.0 Rubus occidentais 1OO.O Amelanchier sanguinea (Pursh) DC. 46.5 Rumex crispus linné 1OO.O Angelica archangelica 39.1 Salvia elegens 69.7 Arachis hypogaea 81.8 Salvia officinalis 1OO.O Aralia nudicatiis 44.9 Salvia officinalis 58.0 Arctium minus (Hill) Bernhardi 35.6 Salvia officinalis 1OO.O Arctostaphylos tiva-lisi 59.9 Salvia officinalis 39.9 Aronia melanocarpa (Michx.) Ell. 28.4 Salvia officinalis 45.7 Artemisia Ludoviciana 66.O Salvia officinalis 65.4 Aster sp? 51.8 US 2009/0263516 A1 Oct. 22, 2009 57

TABLE 7-continued TABLE 7-continued

Cath G Cath G

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Aster sp? 1OO.O Monarda didyma 35.8 Beta vulgaris 26.5 N 1OO.O Brassica naptis 32.9 N 34.8 Brassica naptis 33.5 Nepeta Cataria 38.4 Brassica oleracea 1OO.O Ocimum basilicum 20.4 Calamintha nepeta 51.5 Ocimum basilicum 89.9 Calendula officinalis L. 26.7 Ocimum basilicum 31.3 Canna eduis 20.6 Ocimum basilicum 82.3 Chaerophyllum bulbosum 37.0 Oenothera biennis linné 62.8 Chaerophyllum bulbosum 88.6 Oenothera biennis linné 1OO.O Chaerophyllum bulbosum 26.5 Oenothera biennis linné 1OO.O Chichorium endivia 25.2 Oenothera biennis Linne 1OO.O Chrysanthemum leucanthemum linné 44.2 Origantim vulgare 67.1 Cicer arietintin 26.1 Origantim vulgare 65.5 Cichorium endi via 23.7 Origantim vulgare S8.1 Cichorium intybus 1OO.O Origantim vulgare 70.5 Cichorium intybus 79.2 Origantim vulgare 34.5 Cichorium intybus 82.5 Origantim vulgare 60.1 Crataegus sp? 27.9 Origantim vulgare 1OO.O Cynara Scolymis 66.3 Origantim vulgare 28.5 Dirca palustris 28.8 Origantim vulgare 83.7 Dirca palustris 85.2 Origantim vulgare 22.1 Dryopteris filix-mas 1OO.O Oxyria digyna 57.7 Echinacea purpurea 84.2 Perilla frutescens 75.8 Echinacea purpurea 83.2 Peucedanum cervaria 37.5 Erigeron speciosus (Lindl.) D.C. 46.1 Peucedanum cervaria 25.3 Fagopyrim esculenium 27.5 Plantago major 31.7 Filipendula rubra 59.6 Plectranthus sp. 28.5 Gainsoga ciliata (Rofiresque) Blake 2O.S Portulaca oleracera linné 37.8 Gaium odoratum 56.8 Potentiiia anserina 21.1 Gaultheria hispidula (L.) Muhl 1OO.O Poterium sanguisorba 72.1 Glycine max 22.8 Poterium sanguisorba 65.9 Glycyrrhiza glabra 28.4 Poterium sanquisorba 63.6 Hamamelis virginiana 33.8 Poterium sanquisorba 28.7 Hamamelis virginiana 1OO.O Prunella vulgaris 40.7 Heianthus annus 26.5 Pteridium aquilinum 25.7 Heianthus strumosus 21.2 Pteridium aquilinum 1OO.O Heianthus tuberosus L. 48.4 Raphantis Raphanistrain 42.7 Helichrysum angustifolium 38.1 Ribes nidigrolaria 45.9 Helichrysum angustifolium 83.8 Ribes nigrum 35.9 Helichrysum thianschanicum Regel 61.3 Ribes Silvestris 34.9 Heliotropium arborescens 56.2 Ribes Uva-crispa 3O.S Heliotropium arborescens S4.9 Ricinits communis 95.0 Huntilus lupulus 70.5 Ricinits communis 48.3 Huntilus lupulus 43.0 Rosa rugosa thunb. 40.3 Hypericum hennyi 31.0 Rosa rugosa thunb. 97.8 Hyperictim perforatin 1OO.O Rosmarinus officinalis 1OO.O Initia heienium 85.3 Rosmarinus officinalis 54.1 Initia heienium 74.7 Rosmarinus officinalis 77.7 Initia heienium 37.4 Rosmarinus officinalis 72.2 Ipomea batatas 39.0 Rubus Canadensis 25.3 Isa is tinctoria 1OO.O Rubus idaeus L. 31.1 Laportea Canadensis 26.9 Rubus idealis 1OO.O Latiri is nobilis 51.5 Rubus idealis 37.6 Latiri is nobilis 1OO.O Rubus idealis 34.8 Lavendula angustifolia 44.4 Rubus occidenia is 93.3 Lavenditia iaiifolia 44.8 Rubus occidenia is 22.7 Ledum groenlandictim 1OO.O Rubus occidenia is 21.6 Levisitectim officinale 39.6 Rumex crispus linné 1OO.O Matricaria recitita 1OO.O Rumex crispus linné 1OO.O Melissa officinalis 98.0 Salvia elegens 41.3 Melissa officinalis 76.3 Salvia elegens 62.9 Melissa officinalis 36.6 Salvia officinalis 43.3 Melissa officinalis 80.6 Salvia officinalis 55.1 Mentha arvensis 83.5 Salvia officinalis 1OO.O Mentha piperita 79.0 Salvia officinalis 52.5 Mentha piperita vulgaris 45.9 Salvia officinalis 1OO.O Menthapulegitim 47.0 Salvia officinalis 38.8 Mentha spicaia 73.9 Salvia officinalis 49.5 Mentha spicaia 813 Salvia officinalis 95.3 Mentha spicaia 93.0 Salvia officinalis 41.3 US 2009/0263516 A1 Oct. 22, 2009 58

TABLE 7-continued TABLE 7-continued

Cath G Cath G

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Saivia Sciarea 31.1 Artemisia draculus 2O2 Sarrietie commune 59.7 Artemisia dractinius 37.2 Sarrietie vivace 72.3 Artemisia Ludoviciana 54.8 Sarrietie vivace 26.O Aster sp? 43.4 Satureia montana 78.5 Aster sp? 99.9 Satureia montana 1OO.O Apertis escientiis 46.9 Soianum tuberosum 35.8 Beta vulgaris 81.4 Sonchi is oleracetis L. 410 Beta vulgaris 30.6 Sorghum dochna 1OO.O Betula glanditiosa 58.2 Sorghum Sudanense 32.6 Borago officinalis 2O2 Sorghum Sudanense 39.7 Brassica iuncea 56.6 Symphytum officinale 79.4 Brassica naptis 34.1 Symphytum officinale 74.6 Brassica nigra 32.3 Tanacetain parthenium 23.1 Brassica rapa 21.4 Tanacetain parthenium 24.3 Calamintha nepeta 71.4 Tanacetum vulgare 20.8 Calamintha nepeta 30.3 Tanacetum vulgare 32.O Canna eduis 31.9 Tanacetum vulgare 58.5 Canneberge 66.3 Tanacetum vulgare “Goldsticks' 44.8 Capsella bursa-pastoris (linné) médicus 37.1 Taraxacum officinale 58.2 Carya cordiformis 1OO.O Thymus fragantissuinus 39.9 Chaerophyllum bulbosum 86.0 Thymus herba-barona 26.6 Chrysanthemum leucanthemum linné 45.4 Thymus herba-barona 35.7 Cichorium intybus 74.8 Thymus praecox. Subsp. arctiitis 78.O Cichorium intybus 23.8 Thymus serpyllum 47.4 Cichorium intybus 38.9 Thymus serpyllum 1OO.O Clinicifiiga racemosa 65.1 Thymus serpyllum 22.6 Citrulius colocynthus SO.2 Thymus serpyllum 70.2 Citrus innettoides 45.1 Thymus vulgaris 40.8 Citrus innettoides 28.9 Thymus vulgaris 37.3 Citrus innon 25.9 Thymus vulgaris Argenteus' 87.7 Citrus innon 43.3 Thymus X citriodorus 27.2 Coix Lacryma-Jobi 22.1 Vaccini in anglisiifolium 41.7 Coriandrum sativum 62.O Vaccinum macrocarpon 63.5 Crataegus sp? 44.0 Viburnum trilobum Marsh. 67.7 Crataegus Suibnois 40.7 Viburnum trilobum Marsh. 23.6 Crataegus Suibnois 29.3 Vicia Saiva 38.5 Circlina longa syn. C. domestica 22.2 Vicia viliosa 25.2 Cynara Scolymis 42.2 Vitia sp. 24.8 Dioscorea batatas 29.1 Vitia sp. 1OO.O Dioscorea batatas 28.9 Vitia sp. 1OO.O Diospiros Kaki 57.8 Vitia sp. 20.8 Dirca palustris 39.2 Zea mays 53.7 Doichus iabiah 42.9 Achillea millefolium 4.1.8 Dryopteris filix-mas 24.9 Achillea millefolium 31.5 Dryopteris filix-mas 1OO.O Acorus calamus 68.4 Echinacea purpurea 78.9 Acorus calamus 39.2 Echinacea purpurea 95.8 Adiantum pedatum 1OO.O Echinacea purpurea 53.7 Agastache foeniculum 78.O Erigeron speciosus (Lindl.) D.C. 96.2 Agastache foeniculum “Snow Pike' 34.5 Fragaria 42.7 Agastache foeniculum “Snow Pike' S4.3 Fragaria Xananassa 1OO.O Agrimonia eupatoria 1OO.O Fragaria Xananassa 1OO.O Aichemia nois 37.1 Fruit de la passion 30.2 Aichemia nois 1OO.O Fictis vesiclitosis 93.3 Aichemia nois 98.8 Gainsoga ciliata (Rofiresque) Blake. 33.0 Aichemia nois 24.3 Gaium odoratum 27.0 Aichemia nois 83.7 Gaultheria hispidula (L) Muhl 1OO.O Aichemia nois 80.0 Gaultheria procumbens 3O.O Althaea officinalis 34.1 Gaultheria procumbens 1OO.O Althaea officinalis 34.3 Glycine max Envy 20.1 Althaea officinalis 30.8 Glycyrrhiza glabra 47.9 Ambrosia artemisiifolia linné 61.6 Guizotia abyssinica 74.1 Ambrosia artemisiifolia linné S2.1 Guizotia abyssinica 22.7 Amelanchier sanguinea XA. laevis 38.6 Hamamelis virginiana 1OO.O angelica archangelica 54.8 Hamamelis virginiana 1OO.O Anthemistinctorium 67.7 Helenium hoopesii 21.7 Arachis hypogaea 85.1 Helenium hoopesii 24.6 Aralia nudicatiis 742 Heianthus annus 21.O Arctostaphylos tiva-lisi 98.8 Heianthus strumosus 85.6 Arctostaphylos tiva-lisi 82.4 Heianthus tuberosa 64.5 Aronia prunifolia 27.3 Heianthus tuberosa 1OO.O US 2009/0263516 A1 Oct. 22, 2009 59

TABLE 7-continued TABLE 7-continued

Cath G Cath G

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Helichrysum angustifolium O 1OO.O Origantim vulgare O 1OO.O Helichrysum angustifolium 87.O Origantim vulgare 51.7 Helichrysum angustifolium 84.4 Origantim vulgare 30.8 Helichrysum angustifolium 92.3 Origantim vulgare 25.4 Helichrysum thianschanicum Regel 59.5 Origantim vulgare 38.2 Heliotropium arborescens 85.1 Oxyria digyna 23.1 Hibiscus cannabinus 2S.O Pastinaca Saiiva 33.1 Huntilus lupulus 21.4 Pastinaca Saiiva 22.2 Huntilus lupulus 21.5 Perilla frutescens 1OO.O Huntilus lupulus 88.4 Perilla frutescens 61.7 Huntilus lupulus 22.5 Perilla frutescens 75.6 Hyperictim perforatin 1OO.O Petroselinum crispum Nyman ex. A. W. Hill 24.8 Initia heienium 97.1 Peucedanum cervaria 53.0 Initia heienium 69.0 Peucedanum cervaria 35.9 Initia heienium 29.3 Plafia paniculala 85.9 Ipomea bataias 27.0 Phaseolus vulgaris 35.7 Iris versicolor 22.9 Phytolacca americana 28.6 Juniperus communis 1OO.O Phytolacca decandra syn. P. americana 31.6 Krameria Triandra S2.6 Plectranthus sp. 66.O Lathyrus Sylvestris 32.5 Polygonium chinense 33.2 Latiri is nobilis 1OO.O Polygonum aviculare linné 1OO.O Lavendula angustifolia 74.8 Popitius Xpetrowskyana 25.4 Lavendula angustifolia 70.2 Potentiiia anserina 55.8 Lavenditia iaiifolia 85.6 Poterium sanguisorba 1OO.O Lavenditia iaiifolia 6.3.3 Poterium sanguisorba 82.3 Lavenditia iaiifolia 2O2 Prunella vulgaris S2.6 Ledum groenlandictim 1OO.O Psoralea coryiifolia 21.3 Ledum groenlandicum 94.1 Psoralea corylifolia 26.O Lepidium sativum 2O.S Psoralea coryiifolia 27.4 Litchi chinensis 1OO.O Pteridium aquilinum 1OO.O Lolium multiflorum 22.7 Punica granatin 21.3 Lonicera ranosissina 30.9 Punica granatin 77.1 Lotus corniculatus 60.2 Punica granatin 43.9 Maius 23.1 Radix Rehmannia 23.9 Maiva moschata 31.4 Raphantis raphanistrain 36.5 Melissa officinalis 81.4 Raphantis raphanistrain 3O.S Melissa officinalis 87.5 Rhamnus fianguia 1OO.O Melissa officinalis 1OO.O Rheum palmatum 1OO.O Melissa officinalis 36.0 Rianits communis 1OO.O Melissa officinalis 36.8 Rianits communis 1OO.O Melissa officinalis 1OO.O Rianits communis 68.2 Melissa officinalis 30.3 Ribes Grossiliaria L. 61.1 meniha arvensis 67.2 Ribes nidigrolaria 32.1 Mentha piperita 20.8 Ribes nigrum 90.2 Mentha piperita 1OO.O Ribes nigrum 20.3 Mentha piperita 26.9 Ribes nigrum L. 21.1 Mentha piperita 97.8 Ribes nigrum L. S1.6 Mentha piperita vulgaris 2O2 Ribes sativam Syme 20.9 Mentha piperita vulgaris 42.5 Ribes tiva-crispa 4.1.8 Menthapulegitim 1OO.O Rosa rugosa OO.O Mentha spicaia S1.6 Rosa rugosa thumb. 94.1 Mentha spicaia 81.8 Rosmarinum officinalis OO.O Mentha spicaia 1OO.O Rosmarinum officinalis 40.O Mentha spicaia 1OO.O Rosmarinum officinalis 76.9 Mentha spicaia 23.2 Rubus Canadensis 31.3 Nepeta Cataria 62.8 Rubus Canadensis 22.8 Ocimum Basilicum 41.1 Rubus Canadensis OO.O Ocimum Basilicum 40.O Rubus idaeus 2S.O Ocimum Basilicum 28.4 Rubus idaeus L. OO.O Oenothera biennis linné 67.3 Rubus idealis 46.1 Oenothera biennis linné 1OO.O Rubus idealis 32.O Onobrychis viciafolia 34.O Rubus idealis 28.5 Origantin nationara 29.5 Rubus occidenia is OO.O Origantim vulgare 55.5 Rubus occidenia is 23.5 Origantim vulgare 67.7 Rimes Scittatus 27.1 Origantim vulgare 46.4 Rumex acetosella linné 23.0 Origantim vulgare 68.6 Rumex crispus linné OO.O Origantim vulgare 99.9 Rumex crispus linné OO.O Origantim vulgare 42.O Salvia (elegens) OO.O Origanum Vulgare 28.8 Salvia elegens 63.5 Origanum Vulgare 46.7 Salvia officinalis 34.O US 2009/0263516 A1 Oct. 22, 2009 60

TABLE 7-continued TABLE 7-continued

Cath G Cath G

Inhibition Inhibition Nom latin Stress Extrait (%) Nomlatin Stress Extrait (%) Salvia officinalis 41.7 T W S8.9 64.3 Vitia sp. Salvia officinalis T S 24.7 Salvia officinalis 1OO.O Vitis sp Salvia officinalis 38.8 Vitis sp. T S 22.8 Salvia officinalis 73.4 Vitis sp. T S 21.7 Salvia officinalis 95.3 Zea mayS T S 2O.S Salvia officinalis 56.8 Salvia officinalis 25.1 Saivia Sciarea 28.6 Sambucus Canadensis 40.1 TABLE 8 Sambucus Canadensis L. SO.2 Sambucus caradensis 29.7 Cath L Sanguisorba minor 32.O Sanguisorba minor 59.5 Nomlatin Stress Extrait Inhibition (%) Sanguisorba minor 58.5 Sanguisorba minor 68.5 Actinidia argutta 6.3.3 Satureia hortensis 66.5 Actinidia argutta 46.3 Satureia hortensis 20.1 Achillea millefolium 32.4 Satureia montana 43.3 Achillea millefolium 26.3 Satureia montana 36.7 Aconium napeiitis 3O.O Satureia montana 1OO.O Acorus calamus 25.9 Satureia montana 81.1 Adiantum pedatum 2O2 Satureia montana 40.6 Adiantum pedatum 22.2 Satureia montana S4O Agropyron repens 98.6 Satureia montana 90.1 Agropyron repens 618 Satureia repandra 35.8 Aichemia nois 75.7 Satureia repandra 1OO.O Aichemia nois 36.5 Satureja repandra 75.O Allium porrum 39.7 Soianum Tiiberosum 30.9 Allium porrum 58.2 Solidago Canadensis 91.8 Allium cepa 51.0 Sonchi is oleracetis L. 45.9 Aium sativum 53.8 Sorghum dochna Snowdrew 31.5 Allium Schoenoprastin 74.6 Sorghum Sudanense 33.6 Aium Tuberosum 69.5 Stipa capillaia L. 33.0 Aloe vera 44.7 Symphytum officinale 94.1 Aloe vera 55.6 Symphytum officinale 42.8 Althaea officinalis 95.0 Tanacetain parthenium 40.1 Althaea officinalis 33.4 Tanacetain parthenium 33.6 Amaranthus retroflexus 74.5 Tanacetum vulgare 36.5 Amaranthus retroflexus 98.4 Tanacetum vulgare 51.2 Anethlin graveolens 37.4 Tanacetum vulgare 95.6 Anethlin graveolens 58.7 Tanacetum vulgare 38.4 Angelica archangelica 79.1 Tanacetum vulgare 27.4 Apium graveolens 27.9 Tanacetum vulgare “Goldsticks' 37.9 Apium graveolens 46.5 Taraxacum officinale 57.8 Aralia nudicatiis 89.3 Thymus fragantissuinus 34.O Aralia nudicatiis SS.4 Thymus fragantissuinus 72.7 Arctii in lappa 32.8 Thymus fragantissuinus 71.O Arctii in minus 72.5 Thymus praecox. Subsp. arctiitis 59.2 Arctii in minus 61.3 Thymus pseudoianuginostis 85.7 Armoracia rusticana 95.8 Thymus pseudoianuginostis 20.9 Aronia melanocarpa 39.8 Thymus serpyllum 94.8 Aronia melanocarpa 28.2 Thymus serpyllum 38.4 Artemisia Absinthium 51.7 Thymus vulgaris 1OO.O Artemisia Absinthium 63.7 Thymus vulgaris Argenteus' 80.4 Artemisia dractinctiitis 45.4 Thymus Xcitriiodorus 1OO.O Aster sp 4.1.8 Tiarella cordifolia 1OO.O Aster sp 91.5 Trichosanthes kirillowii 1OO.O Atropa belladonna 47.3 Triticale sp. 24.4 Atropa belladonna 31.7 Tropaeoluim maints 20.6 Beckmannia eruciformis 4.O.S Ulmus americana 43.7 Beckmannia eruciformis 60.8 Urtica dioica 28.9 Beta vulgaris 66.1 Vaccinium anglisiifolium 43.2 Beta vulgaris 79.5 Vaccinium anglisiifolium 42.4 Beta vulgaris spp. Maritina 6.3.3 Vaccinium macrocarpon 59.2 Beta vulgaris spp. Maritina 59.1 Vaccinium macrocarpon 27.2 Borago officinalis 40.9 Vaccinium macrocarpon 21.6 Brassica naptis 64.6 Vaccinum macrocarpon 62.6 Brassica naptis 21.1 Veronica officinalis S2.6 Brassica oleracea 66.6 Viburnum trilobum Marsh. 1OO.O Brassica oleracea 68.6 Vicia viliosa 36.6 Brassica rapa 99.0 US 2009/0263516 A1 Oct. 22, 2009 61

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Brassica rapa 99.3 Latiri is nobilis 46.1 Campaniiia raptinctius 59.0 Leonirits cardiaca 6.3.3 Campaniiia raptinctius SO.6 Leonirits cardiaca 24.5 Canna eduis 23.9 Levisticum officinale 20.9 Capsella bursa-pastoris 49.O Levisticum officinale 43.8 Capsella bursa-pastoris 47.0 Lotus corniculatus 59.0 Capsicum annittin 29.1 Lotus corniculatus 87.4 Cartin carvi 60.4 Lycopersicon escientiin 28.0 Chaerophyllum bulbosum 48.6 Malva Sylvestris 23.1 Chaerophyllum bulbosum 48.2 Medicago Saiiva 63.8 Chelidonium maius 35.5 Medicago Saiiva S3.6 Chelidonium maius 23.1 Meilotus aibus 93.7 Chenopodium bonus-henricus 65.9 Meilotus aibus 80.1 Chenopodium quinoa 62.3 Melissa officinalis 40.8 Chenopodium quinoa 90.0 Melissa officinalis 69.5 Cicer arietintin 82.4 Mentha piperita 61.O Cichorium intybus 58.0 Mentha piperita 73.2 Cichorium intybus 81.7 Menthapulegitim 69.0 Coix Lacryma-Jobi 32.6 Mentha spicaia 94.6 Coix Lacryma-Jobi 43.4 Mentha suaveolens 55.2 Coriandrum sativum 26.9 Nepeta Cataria 45.9 Coriandrum sativum 6S.O Nepeta Cataria 66.3 Cornus Canadensis 99.7 Nicotiana tabacum 46.8 Cornus Canadensis 60.6 Oenothera biennis 69.8 Crataegus sp 25.9 Oenothera biennis 47.3 Crataegus sp 28.2 Origantin majorana 38.5 Cryptotaenia Canadensis 73.3 Origantim vulgare 43.3 Cryptotaenia Canadensis 36.1 Origantim vulgare 68.2 Cymbopogon citratus 32.7 Panax quinquefolius 41.7 Cypertis escientiis 41.3 Panax quinquefoils 83.7 Cypertis escientiis 33.8 Pastinaca Saiiva 62.8 Daiiciis Caroia 63.6 Pastinaca Saiiva 44.2 Daiiciis Caroia 43.4 Perilla frutescens 66.2 Dirca palustris 61.1 Petasitesiaponicus 22.6 Dirca palustris 46.6 Petasitesiaponicus 25.5 Echinacea purpurea 54.8 Petroselinum crispum 79.1 Eleusine coracana 36.4 Petroselinum crispum 32.3 Fagopyrim esculenium 37.9 Phaiaris canariensis 45.4 Fagopyrim esculenium 43.3 Phaseolus vulgaris 31.0 Fagopyrim tatarictim 28.4 Phaseolus Vulgaris 618 Fagopyrim tatarictim 32.8 Pimpinella anisum 38.1 Foeniculum vulgare 48.8 Plantago major 95.1 Fragaria Xananassa 46.3 Plectranthus sp. 76.9 Fragaria Xananassa 78.8 Plectranthus sp. 58.0 Gainsoga ciliata 46.0 Polygonum aviculare 28.0 Gaium odoratum 59.8 Polygonum aviculare 49.7 Gaium odoratum 79.5 Potentiiia anserina 26.6 Gaultheria hispidula 53.4 Poterium Sanquisorba 58.0 Gaultheria hispidula S4.3 Pteridium aquilinum 32.9 Giechona hederacea 23.4 Raphantis raphanistrain 70.7 Giechona hederacea 26.9 Raphantis raphanistrain 83.2 Glycine max 2O.S Raphantis Saivais 90.9 Glycine max 73.8 Raphantis sativits 95.4 Glycyrrhiza glabra 57.7 Rheum rhabarbarium 26.0 Glycyrrhiza glabra 53.8 Rheum rhabarbarium 62.9 Guizotia abyssinica 29.6 Ribes nigrum 62.9 Guizotia abyssinica 78.6 Ribes Sylvestre 34.5 Hamamelis virginiana 41.2 Ribes Sylvestre 80.3 Hedeona ptilegioides 26.3 Ricinits communis 89.9 Helleborus niger 36.9 Ricinits communis 81.0 Helleborus niger 35.4 Rosa rugosa 32.9 Hordeum hexastichon 31.1 Rosa rugosa 35.9 Hyssopus officinalis 84.8 Rosmarinus officinalis 78.2 Hyssopus officinalis 85.8 Rubus allegheniensis 76.8 Initia heienium 58.4 Rubus Canadensis 40.7 Initia heienium 32.7 Rubus Canadensis 72.6 Ipomoea Batatas 29.6 Rubus idaeus 35.5 Lathyrus Saivais 31.7 Rubus idaeus 97.9 Lathyrus Saivais 71.1 Rumex Acetosa 32.O Lathyrus Sylvestris 65.3 Rumex acetoseiia 73.2 Lathyrus Sylvestris 66.4 Rumex acetoseiia 56.9 Latiri is nobilis 43.1 Rumex crispiis 49.7 US 2009/0263516 A1 Oct. 22, 2009 62

TABLE 8-continued TABLE 8-continued

Cath L Cath L Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Rumex crispiis 37.5 Zea mayS 93.8 Rumex Scittatus 53.1 Achillea millefolium 45.8 Rumex Scittatus 25.9 Achillea millefolium 24.6 Rita graveolens 56.2 Aconium napeiitis 28.7 Salix purpurea 71.4 Acorus calamus 37.5 Salix purpurea 24.7 Acorus calamus 32.8 Salvia elegans 67.6 Actinidia argutta 47.8 Salvia officinalis 70.5 Actinidia argutta 78.4 Salvia officinalis 56.6 Adiantum pedatum 45.9 Saivia Sciarea 70.1 Adiantum pedatum 27.0 Santolina Chamaecyparissus 59.5 Agropyron repens 83.0 Santolina Chamaecyparissus 59.2 Agropyron repens 31.9 Satureia montana 71.7 Aichemia nois 71.O Scorzonera hispanica 21.9 Allium ampeioprastin 36.8 Secale cereale 33.3 Allium ampeioprastin 62.2 Senecio vulgaris 47.5 Allium cepa 56.1 Senecio vulgaris 20.8 Allium cepa 64.4 Setaria itaica 48.6 Aium sativum 65.2 Setaria itaica 37.1 Allium Schoenoporastin 78.4 Siim Sisartin 33.8 Aium tuberosum 46.6 Siim Sisartin 62.5 Aloe vera 45.7 Soianum tuberosum S3.6 Aithaca officianalis SO.O Solidago sp S4.O althaea officinalis 42.2 Solidago sp 95.1 Amaranthus retroflexus 41.7 Sonchi is oleracetis 59.4 Amaranthus retroflexus 90.3 Sonchi is oleracetis 692 Anethlin graveolens 31.3 Sorghum dochna 33.9 Anethlin graveolens 6O.S Sorghum dochna 55.3 Angelica archangelica 64.3 Sorghum durra 61.3 Angelica archangelica 6.3.3 Sorghum durra 83.9 Apium graveolens 57.0 Stachys byzantina 61.6 Apium graveolens 28.4 Stachys byzantina 73.8 Aralia nudicatiis 71.8 Stellaria graminea 40.1 Aralia nudicatiis 38.2 Stellaria graminea 55.8 Arctii in minus 42.4 Steiaria media 70.9 Arctii in minus 41.5 Steiaria media 514 Armoracia rusticana 67.1 Tanacetum cinerariifolium 67.7 Aronia melanocarpa 32.O Tanacetain parthenium SO.8 Aronia melanocarpa 7O.O Tanacetain parthenium 819 Artemisia absinthium 63.1 Tanacetum vulgare 56.2 Artemisia absinthium 61.1 Tanacetum vulgare 51.9 Asclepias incarnata 58.4 Taraxacum officinale 98.7 Asclepias incarnata 6.3.3 Taraxacum officinale 82.1 Asparagus officinalis 61.2 Teucrium chamaedrys 62.2 Asparagus officinalis 86.3 Thymus praecox. Subsp. arcticus 42.O Aster Linne 57.5 Thymus praecox. Subsp. arcticus 54.2 Aster sp 48.7 Thymus serpyllum 93.4 Aster sp 94.5 Thymus serpyllum 57.5 Atropa belladonna 29.2 Thymus vulgaris 68.7 Beckmannia eruciformis 32.9 Thymus vulgaris 55.8 Beta vulgaris 47.9 Thymus X citriodorus 72.8 Beta vulgaris 61.9 Thymus X citriodorus 31.9 Borago officinalis 51.9 Tragopogon porrifolius 67.2 Brassica Naptis 92.1 Tragopogon porrifolius 37.0 Brassica naptis 30.2 Tropaeoluim maints 62.8 Brassica oleracea 79.0 Typha latifolia 77.5 Brassica oleracea 85.4 Typha latifolia 70.6 Brassica rapa 81.7 Vaccinium Corymbosum 74.7 Calamagrostis artindiflora 59.7 Vaccinium Corymbosum 69.5 Campaniiia raptinctius 65.4 Vaccinium macrocarpon 71.4 Campaniiia raptinctius 54.8 Vaccinum macrocarpon 78.9 Canna eduis 3O.O Verbascum thapsus 76.8 Capsella bursa-pastoris 48.1 Verbascum thapsus 62.O Capsella bursa-pastoris SO.9 Vicia Saiva 79.2 Cartin carvi 624 Vicia Saiva 88.7 Cerastii in to mentostin 45.1 Vicia viliosa 74.5 Chaerophyllum bulbosum 3O.O Vicia viliosa 61.O Chaerophyllum bulbosum 54.5 Vinca minor 46.7 Chelidonium maius 43.2 Vinca minor 31.9 Chelidonium maius 30.7 Vitis sp. 89.5 Chichorium endivia 642 Vitis sp. 54.6 Chichorium endivia subspendivia 48.3 Zea mays 52.O Chichorium endivia subspendivia 67.0 US 2009/0263516 A1 Oct. 22, 2009 63

TABLE 8-continued TABLE 8-continued

Cath L Cath L

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Cichorium intybus G O 78.3 Leonirits cardiaca G R 38.5 Cichorium intybus G R 87.8 Levisitectim officinale G R 51.2 Circium arvense G R 94.1 Levisitectim officinale G O 78.3 Circium arvense G O 58.7 Lotus corniculatus G O 86.8 Coix Lacryma-Jobi G R 35.7 Lotus corniculatus G R S.O.3 Coix Lacryma-Jobi G O 31.4 Lupinus polyphyllius G R 78.9 Cornus Canadensis G R 61.3 Lupinus polyphyllius G O 66.7 Cornus Canadensis G O 80.6 Maius hupehensis G R 52.7 Crataegus Suibnois G R 21.0 Maius hupehensis G O 64.1 Crataegus Suibnois G O 44.4 Malva Sylvestris G R 26.2 Cymbopogon citratus G R 39.6 Medicago Saiiva G R 43.4 Cypertis escientiis G R 624 Medicago Saiiva G O 92.5 Cypertis escientiis G O 49.6 Meilotus aibus G R 75.5 Daiiciis Caroia G O 36.3 Meilotus aibus G O 7O.O Daiiciis Caroia G R 44.3 Melissa officinalis G O 81.1 Dirca palustris G O 85.1 Mentha piperita G O 544 Dirca palustris G R 47.1 Menthapulegitim G O 59.4 Echinacea purpurea G O 36.4 Mentha spicaia G R 38.8 Eleusine coracana G O 65.4 Mentha spicaia G O 83.0 Eleusine coracana G R 36.8 Mentha suaveolens G O 56.5 Erigeron speciosus G R 39.1 Nepeta Cataria G O 56.2 Erysimum perofskianum G R 58.7 Ocimum basilicum G O 60.3 Erysimum perofskianum G O 93.1 Oenothera biennis G R 39.2 Fagopyrim esculenium G R 36.4 Oenothera biennis G O 44.3 Fagopyrim esculenium G O 41.O Origantin majorana G O 44.7 Fagopyrim tatarictim G R 43.3 Origantim vulgare G O S8.1 Fagopyrim tatarictim G O 29.1 Origantim vulgare G R 22.9 Gainsoga ciliata G R 49.8 Oryza Sativa G R 71.8 Gainsoga ciliata G O 58.0 Oryza Sativa G O 39.8 Gaium odoratum G R 65.1 Oxalis Deppei G R 80.1 Gaium odoratum G O 94.2 Oxalis Deppei G O 28.8 Gaultheria hispidula G R 55.7 Oxyria digyna G R 51.8 Gaultheria hispidula G O SO.6 Oxyria digyna G O 36.2 Gaultheria procumbens G R 53.3 Panax quinquefoils G R 72.1 Gaultheria procumbens G O 67.7 Panax quinquefoils G O 81.6 Giechona hederacea G O 70.9 Panicum miliaceum G O 93.4 Giechona hederacea G R 25.3 Passiflora caerula G R 33.2 Glycine max G R 78.6 Passiflora caerula G O 63.2 Glycine max G O 85.9 Pastinaca Saiiva G O S4.O Glycyrrhiza glabra G R 59.1 Pennisetum alopectiroides G R 61.O Glycyrrhiza glabra G O 60.6 Petasitesiaponicus G O SO.O Guizotia abyssinica G R 4.1.8 Petroselinum crispum G R 49.1 Guizotia abyssinica G O 74.3 Petroselinum crispum G O 52.2 Hamamelis virginiana G R 44.2 Phaiaris canariensis G O 72.1 Heianthus strumosus G O 40.6 Phaseolus vulgaris G R 21.8 Heianthus strumosus G R 61.4 Pimpinella anisum G O 86.2 Heianthus tuberosus G O 75.1 Pistin Saivain G O 61.6 Heianthus tuberosus G R 30.1 Pistin Saivain G R 57.5 Helichrysum thianschanicum G R 56.3 Plantago major G O 91.9 Helichrysum thianschanicum G O 84.O Plectranthus sp. G R 53.0 Helleborus niger G O 38.8 Plectranthus sp. G O 73.0 Helleborus niger G R 25.9 Polygonum aviculare G R 32.2 Hordeum hexastichon G O 62.3 Polygonum aviculare G O 36.4 Hordeum hexastichon G R 29.4 Portuiaca oierracea G R 82.1 Hyssopus officinalis G R 64.7 Portuiaca oierracea G O 6.3.3 Hyssopus officinalis G O 71.9 Potentiiia anserina G R 26.3 Initia heienium G O 29.4 Poterium sanquisorba G O 79.9 Initia heienium G R 25.7 Prunella vulgaris G R 68.8 Ipomoea batatas G O 36.9 Prunella vulgaris G O 57.4 Lactica Saiiva G O 704 Raphantis Raphanistrain G R 91.9 Lactica Saiiva G R 49.9 Raphantis Raphanistrain G O 55.2 Lathyrus Saivais G O 62.8 Rhaphanaissativits G R 55.7 Lathyrus Saivais G R 29.0 Rhaphanaissativits G O 78.4 Lathyrus Sylvestris G R 52.1 Rheum rhabarbarium G R 27.1 Lathyrus Sylvestris G O 52.5 Rheum rhabarbarium G O 56.8 Latiri is nobilis G R 27.1 Ribes nidigrolaria G O 70.7 Latiri is nobilis G O 61.O Ribes nigrum G R 37.9 Lavandhiia anguistifolia G R 51.9 Ribes nigrum G O 98.9 Lavandhiia anguistifolia G O 57.0 Ribes Sylvestris G R 25.2 Ledum groenlandictim G O 734 Ribes Sylvestris G O 65.7 Ledum groenlandictim G R 52.6 Ricinits communis G R 39.3 Leonirits cardiaca G O 88.8 Ricinits communis G O 84.3 US 2009/0263516 A1 Oct. 22, 2009 64

TABLE 8-continued TABLE 8-continued

Cath L Cath L

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Rosmarinus officinalis G O 68.6 Typha latifolia G R 65.1 Rubus idaeus G O 26.3 Typha latifolia G O 46.9 Rumex crispiis G R 54.2 Vaccinium macrocarpon G O 76.7 Rumex crispiis G O 62.O Vaccinium corymbosum G O 54.5 Rumex Scittatus G O 38.1 Vaccinium corymbosum G R 82.9 Rita graveolens G O 85.0 Vaccinium anguisittifolium G R 27.9 Salix purpurea G R 74.7 Vaccinium anguisittifolium G O 66.8 Salix purpurea G O 38.5 Vaccinium macrocarpon G R 40.7 Salvia elegans G O 54.8 Veratrum viride G O 35.4 Salvia officinalis G R 89.7 Verbascum thapsus G O 72.9 Salvia officinalis G O 84.9 Verbascum thapsus G R 6O.S Saivia Sciarea G O 618 Viburnum trilobum G R 52.6 Sambucus ebulus G R 48.2 Vicia Saiva G R 36.6 Sambucus ebulus G O 98.2 Vicia Saiva G O 83.2 Santolina Chamaecyparissus G R 61.3 Vicia viliosa G O 77.3 Santolina Chamaecyparissus G O 88.2 Vicia viliosa G R 46.8 Saponaria officinalis G R S2.9 Vinca minor G O 63.0 Saponaria officinalis G O 71.8 Vinca minor G R 30.8 Satureia hortensis G O 44.9 Vitis sp. G R 52.7 Satureia montana G O 76.8 Vitis sp. G O 99.2 Scorzonera hispanica G R 32.9 Zea mayS G R 45.1 Scuttellaria laterifiora G O 49.8 Zea mayS G O 55.3 Scuttellaria laterifiora G R 39.6 Achillea millefolium O 46.0 Secale cereale G R 37.0 Achillea millefolium R 32.9 Senecio vulgaris G R 31.0 Aconium napeiitis O 35.2 Senecio vulgaris G O 47.0 Aconium napeiitis R 31.9 Setaria itaica G R 44.9 Acorus calamus O 40.6 Setaria itaica G O 42.O Acorus calamus R 26.9 Silene vulgaris G R 76.8 Actinidia arguta R 8O.O Silene vulgaris G O 92.2 Actinidia argutta O 66.3 Siim Sisartin G O S8.9 Adiantum pedatum O 43.4 Siim Sisartin G R 66.6 Agrimonia eupatoria O 37.5 Soianum melongena G R 66.8 Agropyron repens O 75.0 Soianum tuberosum G O 47.4 Agropyron repens R SO.O Solidago sp G R S3.6 Aichemia nois O 71.6 Solidago sp G O 88.3 Aichemia nois R 81.1 Sonchi is oleracetis G R 62.5 Allium ampeioprastin O 84.4 Sonchi is oleracetis G O 55.5 Allium cepa O 49.2 Sorghum dochna G R 67.4 Allium cepa R 30.1 Sorghum dochna G O 73.7 Aium sativum O 63.8 Sorghum durra G R 24.8 Allium Schoenoprastin O 79.6 Sorghum durra G O 42.3 Aium tuberosum O 55.8 Sorghum Sudanense G R 35.5 Aium tuberosum R 29.6 Sorghum Sudanense G O 66.3 Aloe vera R 30.3 Stachys byzantina G R 75.5 Aloe vera O 42.7 Stachys byzantina G O 66.7 Althaea officinalis R 42.5 Stellaria graminea G R 36.9 Althaea officinalis O 46.3 Stellaria graminea G O 40.1 Amaranthus candatiis R 37.3 Steiaria media G R 31.2 Amaranthus candatiis O 6O.O Steiaria media G O S1.1 Amaranthus retroflexus R 33.2 Symphytum officinale G R 90.2 Amaranthus retroflexus O 94.3 Symphytum officinale G O 90.8 angelica archangelica O 37.4 Tanacetum cinerariifolium G O 76.1 angelica archangelica R 55.7 Tanacetain parthenium G R 70.1 Anthriscus cerefolium O 86.5 Tanacetain parthenium G O 62.4 Anthriscus cerefolium R 69.6 Tanacetum vulgare G R 36.2 Apium graveolens R 22.0 Tanacetum vulgare G O 72.5 Aralia nudicatiis O 77.5 Taraxacum officinale G O 1OO.O Aralia nudicatiis R 28.4 Taraxacum officinale G R 78.6 Arctii in minus R 544 Teucrium chamaedrys G O 50.5 Arctii in minus O 89.5 Teucrium chamaedrys G R 40.1 Armoracia rusticana O 84.9 Thymus fragantissinus G R 81.4 Aronia melanocarpa R 61.9 Thymus fragantissinus G O 58.4 Aronia melanocarpa O 84.5 Thymus praecox. Subsp. arcticus G R 49.2 Artemisia absinthium R 29.0 Thymus praecox. Subsp. arcticus G O 62.4 Artemisia absinthium O 55.9 Thymus serpyllum G O 70.4 Artemisia dractinctiitis O 96.7 Thymus serpyllum G R S4.9 Artium lappa O 26.0 Thymus vulgaris G R 55.1 Asclepias incarnata R 58.5 Thymus X citriodorus G O 47.1 Asclepias incarnata O 66.8 Tiarella cordifolia G O 52.8 Aster spp R 4.O.S Tropaeoluim maints G R 22.2 Aster spp O 86.7 Tropaeoluim maints G O 59.1 Atropa belladonna O 61.4 US 2009/0263516 A1 Oct. 22, 2009 65

TABLE 8-continued TABLE 8-continued

Cath L Cath L

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Atropa belladonna R 3O4 Glycine max O 54.8 Avena Saiiva R 38.0 Glycine max R 38.0 Cypertis escientiis O 47.6 Glycine max O 88.7 Cypertis escientiis R 49.5 Glycyrrhiza glabra O 65.5 Beta vulgaris O 62.2 Glycyrrhiza glabra R 4O.S Borago officinalis O 39.1 Guizotia abyssinica R 48.1 Brassica Naptis O 89.3 Guizotia abyssinica O 84.1 Brassica nigra R 26.9 Hamamelis virginiana R 35.9 Brassica oleracea O 63.9 Hedeona ptilegioides R 24.8 Brassica oleracea R 76.2 Heianthus strumosus O 32.9 Brassica oleracea O 69.9 Heianthus strumosus R 31.0 Bronts inermis R 79.8 Heianthus tuberosus R 42.8 Bronts inermis O 88.1 Heianthus tuberosus O 72.1 Calamagrostis artindiflora in R 62.8 Helichrysum angustifolium R 69.6 Calendula officinalis R 64.6 Helichrysum angustifolium O 84.9 Canna eduis O 47.5 Helichrysum thianschanicum R 96.2 Capsella bursa-pastoris R 48.7 Helichrysum thianschanicum O 80.7 Capsella bursa-pastoris O 40.9 Huntilus lupulus O 71.3 Carex morrowii R 45.7 Huntilus lupulus R 60.6 Carex morrowii O 70.3 Hyoscyami is niger O 68.0 Cartin carvi R 22.7 Hyssopus officinalis R 73.3 Cerastii in to mentostin R 46.8 Hyssopus officinalis O 76.9 Chaerophyllum bulbosum R 22.9 Initia heienium O 93.3 Chaerophyllum bulbosum O 40.9 Initia heienium R 63.5 Chelidonium maius O 60.7 Ipomoea bataias O 99.9 Chelidonium maius R 24.0 Juniperus communis R 26.9 Chenopodium quinoa R 41.5 Kochia Scoparia. O 76.7 Chenopodium quinoa O 86.7 Koeleria giatica R 89.1 Cicer arietintin R 20.4 Koeleria glauca O 67.7 Cicer arietintin O 84.2 Lactica Saiiva O 75.2 Cichorium endi via O 76.3 Lactica Saiiva R 55.3 Cichorium intybus O 81.7 Lathyrus Saiivus R 23.3 Cichorium intybus R 73.3 Lathyrus Saiivus O 70.6 Circium arvense R SO.O Lathyrus Sylvestris R 77.1 Circium arvense O 74.8 Lathyrus Sylvestris O 53.0 Citrulius colocynthus O 62.5 Latiri is nobilis R 61.6 Citrulius colocynthis R 57.3 Latiri is nobilis O 92.7 Coix Lacryma-Jobi R 33.7 Lavandhiia anglisiifolia R 54.1 Coriandrum sativum O 59.2 Lavandhiia anglisiifolia O 84.4 Coriandrum sativum R 37.1 Lavandhiia iaiifolia R SS.4 Cornus Canadensis R 82.6 Lavandhiia iaiifolia O 82.9 Cornus Canadensis O 47.7 Ledum groenlandictim O 96.1 Crataegus sp O 33.9 Ledum groenlandictim R 74.O Crataegus Suibnois O 64.3 Lens citiinaris Subsp. citiinaris R 36.4 Cryptotaenia Canadensis O 60.9 Lens citiinaris Subsp. citiinaris O 1OO.O Cryptotaenia Canadensis R 41.5 Levisticum officinale R 38.8 Cymbopogon citratus R 65.2 Levisticum officinale O 73.4 Cymbopogon citratus O 65.6 Lotus corniculatus O 81.6 Daiiciis Caroia R 27.5 Lotus corniculatus R S2.0 Dioscorea batatas O 423 Lupinus polyphyllius R 53.3 Dirca palustris O 57.4 Lupinus polyphyllius O 64.4 Dirca palustris R 29.5 Luzula sylvatica R 62.6 Echinacea purpurea O 83.0 Maius O 70.9 Eleusine coracana O 70.3 Maius hupehensis R 77.6 Erysimum perofskianum R 90.4 Maius hupehensis O 72.4 Erysimum perofskianum O 92.2 Medicago Saiiva R 41.O Fagopyrim esculenium R 61.6 Medicago Saiiva O 94.1 Fagopyrim esculenium O 39.0 Melilotus officinalis R 44.0 Fagopyrim tatarictim R 36.7 Melilotus officinalis O 90.8 Fagopyrim tatarictim O 25.6 Mentha piperita O 20.6 Foeniculum vulgare O 79.0 Menyanthes trifoliata R 20.8 Fragaria Xananassa O 26.0 Miscanthus sinensis R 89.0 Frangiia aints O 27.0 Miscanthus sinensis O 73.7 Frangiia aints R 45.3 Nepeta Cataria R 25.3 Gainsoga ciliata R 34.6 Ocimum Basilicum O 65.7 Gainsoga ciliata O 60.3 Oenothera biennis R 40.2 Gaium odoratum R 98.8 Oenothera biennis O 49.2 Gaium odoratum O 96.1 Onobrychis viciiafolia R 53.2 Gaultheria hispidula O 33.1 Onobrychis viciiafolia O 49.2 Gaultheria procumbens O 84.2 Origantim vulgare R SO.6 Giechona hederacea O 70.1 Origantim vulgare O 45.1 Giechona hederacea R 38.5 Oryza sativa R 40.3 US 2009/0263516 A1 Oct. 22, 2009 66

TABLE 8-continued TABLE 8-continued

Cath L Cath L

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition (%) Oryza sativa O 28.6 Satureia montana O 43.5 Oxalis Deppei R 35.2 Satureia repandra R 47.1 Oxalis Deppei O 42.1 Satureia repandra O 66.3 oxyria digyna R 42.8 Scuttellaria laterifiora O 20.3 oxyria digyna O 52.3 Scuttellaria laterifiora R 33.8 Panax quinquefolius O 78.8 Secale cereale R 28.5 Panicum miliaceum R 52.6 Senecio vulgaris R 34.0 Passiflora caerulea O 77.5 Setaria itaica R 40.7 Pastinaca Saiiva R 52.O Silene vulgaris R 66.3 Pastinaca Saiiva O 31.8 Silene vulgaris O 99.7 Pennisetum alopectiroides O 734 Siim Sisartin O 90.7 Perilla frutescens R 68.0 Siim Sisartin R 39.6 Perilla frutescens O 744 Solidago Sp R 44.3 Pertoselinum crispum R 65.2 Solidago Sp O 73.6 Petasites Japonicus R 31.3 Sonchi is oleracetis R 53.7 Petasites Japonicus O 24.6 Sonchi is oleracetis O 36.9 Pertoselinum crispum O 45.2 Sorghum cafiorum R 96.4 Phaiaris canariensis R 33.6 Sorghum cafiorum O 80.1 Phaiaris canariensis O 86.5 Sorghum dochna R 95.3 Phaseolus vulgaris O 57.0 Sorghum dochna O 70.3 Physalis pruinosa O 58.2 Sorghum dochna R 98.5 Pimpinella anisum O 95.9 Sorghum dochna O 85.3 Pimpinella anisum R 91.7 Sorghum durra R 86.5 Pistin Saivain R 3O.S Sorghum durra O 81.7 Pistin Saivain O 69.3 Sorghum Sudanense R 34.7 Plantago major O 93.8 Stachys affinis O 75.7 Plantago major R 2O2 Stachys affinis R 33.5 Plectranthus sp. R 44.4 Stachys byzantina R 60.8 Plectranthus sp. O SO.8 Stachys byzantina O 77.5 Polygonum aviculare R 47.9 Stellariagraminea R 37.5 Polygonum aviculare O 72.7 Stellariagraminea O 54.7 Potentiiia anserina R 21.8 Steiaria media R 26.0 Prunella vulgaris R 84.3 Steiaria media O 49.O Prunella vulgaris O 56.7 Stipa capillata R 43.4 Pteridium aquilinum R 32.6 Symphytum officinale R 55.1 Raphantis raphanistrain R 68.6 Symphytum officinale O 64.O Raphantis raphanistrain O 77.0 Tanacetum cinerariifolium O 65.5 Raphantis sativits R 41.O Tanacetain parthenium R 45.2 Raphantis sativits O 63.1 Tanacetain parthenium O 54.7 Ribes Sylvestre O 87.9 Tanacetum vulgare R 59.8 Ribes Siyivestre R 40.2 Tanacetum vulgare O 86.O Ribes Siyivestre O 45.2 Taraxacum officinale O 1OO.O Ricinits communis R 22.4 Taraxacum officinale R 91.3 Ricinits communis O 72.0 Teucrium chamaedrys O 60.8 Ribes nigrum R 50.5 Teucrium chamaedrys L. R 69.2 Ribes nigrum O 70.1 Thymus fragantissinus R 97.8 Rosmarinus officinalis O 69.6 Thymus fragantissinus O 81.7 Rubus Canadensis R 37.2 Thymus praecox. Subsp. arcticus R 36.1 Rubus Canadensis O 57.9 Thymus praecox. Subsp. arcticus O 31.8 Rubus idaeus R 64.9 Thymus pseudoianuginostis R 33.9 Rubus idaeus O 94.9 Thymus pseudoianuginostis O 43.7 Rimes Scittatus O 74.9 Thymus serpyllum R 39.2 Rimes Scittatus R 20.7 Thymus serpyllum O 68.6 Rumex acetoseiia R 40.1 Thymus X citriodorus O 70.9 Rumex acetoseiia O 42.O Thymus X citriodorus R 46.1 Rumex crispiis R 40.7 Tiarella cordifolia O 72.0 Rumex crispiis O 51.2 Tragopogon porrifolius O 40.9 Rita graveolens O 91.2 Tragopogon porrifolius R 2O.S Salix purpurea R 55.5 Triticosecaia spp. O 38.2 Salix purpurea O 51.2 Trictim aestivum R 31.4 Salvia officinalis R 64.7 Trictim aestivum O 33.8 Salvia officinalis O 66.6 Tropaeoluim maints R 29.2 Sambucus Canadensis O 92.5 Tropaeoluim maints O 20.9 Sambucus Canadensis R 64.O Typha latifolia R 67.0 Sanguisorba minor O 68.4 Typha latifolia O 56.0 Santolina Chamaecyparissus R 84.4 Urtica dioica R 77.8 Santolina Chamaecyparissus O 33.9 Urtica dioica O 75.6 Saponaria officinalis R 59.3 Vaccinium anglisiifolium O 58.6 Saponaria officinalis O 804 Vaccinium macrocarpon R 20.1 Satureia hortensis O 26.5 Vaccinium macrocarpon O 41.7 Satureia hortensis R 23.0 Veratrum viride O 57.1 Satureia montana R 57.2 Veratrum viride R 26.6 US 2009/0263516 A1 Oct. 22, 2009 67

TABLE 8-continued TABLE 9-continued

Cath L Cath K

Nom latin Stress Extrait Inhibition (%) Nomlatin Stress Extrait Inhibition Verbascum thapsus T O 72.8 Campaniiia raptinctius A. O 77.0 Verbascum thapsus T R 56.0 Canna eduis A. R 32.O Vibunum trilobum T R 49.5 Capsella bursa-pastoris A. R 71.4 Vibunum trilobum T O 56.8 Capsella bursa-pastoris A. O 72.8 Vicia Saiva T O 73.9 Capsicum annium A. R 39.0 Vicia viliosa T R 79.2 Chaerophyllum bulbosum A. O 86.6 Vicia viliosa T O 70.9 Chelidonium maius A. O 90.3 Vinca minor T O 21.5 Chenopodium bonus-henricus A. O 38.8 Chenopodium quinoa A. R 423 Vitis sp. T R 79.7 Chenopodium quinoa A. O 84.3 Vitis sp. T O 97.4 Cicer arrieintin A. O 91.1 Zea mays T R 83.5 Cichorium intybus A. R 21.0 Zea mays T O 58.2 Cichorium intybus A. O 94.8 Coix Lacryma-Jobi A. O 35.2 Coriandrum sativum A. R 63.6 Coriandrum sativum A. O 84.4 TABLE 9 Cornus Canadensis A. O 58.6 Cornus Canadensis A. R 99.4 Cath K Crataegus sp A. R 22.7 Crataegus Suibnois A. O 45.4 Nom latin Stress Extrait Inhibition Cryptotaenia Canadensis A. R 26.3 Cryptotaenia Canadensis A. O 29.1 Achillea millefolium A. O 27.6 Cymbopogon citratus A. O 45.2 Aconium napelius A. O 74.O Cypertis escientiis A. O 75.0 Acorus calamus A. O 74.8 Daiiciis Caroia A. O 92.9 Actinidia argutta A. R 28.1 Dirca palustris A. O 84.7 Actinidia argutta A. O 96.6 Dirca palustris A. R 94.2 Agropyron repens A. O 98.0 Dryopteris filix-mas A. O 85.7 Aichemia nois A. O 61.3 Echinacea purpurea A. O 89.8 Aichemia nois A. R 95.8 Eleusine Coracana A. R SO.6 Allium cepa A. O 80.6 Eleusine Coracana A. O 58.7 Allium porrum A. R 30.9 Fagopyrim esculenium A. O 68.0 Allium porrum A. O 87.5 Fagopyrim tatarictim A. O 20.3 Aium sativum A. O 71.2 Fagopyrim tatarictim A. R 33.0 Allium Schoenoprastin A. O 78.2 Foeniculum vulgare A. O 40.3 Aium Tuberosum A. O 99.6 Fragaria Xananassa A. R 44.8 Aloe Vera A. R 6O.O Fragaria Xananassa A. O 92.3 Aloe Vera A. O 78.4 Gainsoga ciliata A. O 55.3 Althaea officinalis A. O 98.1 Gaium odoratum A. O 88.4 Amaranthus retroflexus A. R 37.4 Gaultheria hispidula A. R 61.6 Amaranthus retroflexus A. O 43.4 Gaultheria hispidula A. O 87.1 Anethtingraveolens A. O 33.7 Giechona hederacea A. O 96.2 Angelica archangelica A. R 36.0 Glycine max A. R 41.6 Angelica archangelica A. O 85.2 Glycine max A. O 1OOO Apium graveolens A. R 46.7 Glycyrrhiza glabra A. R SO.8 Apium graveolens A. O 88.8 Glycyrrhiza glabra A. O 90.2 Aralia nudicatiis A. R 79.0 Guizotia abyssinica A. R 23.1 Aralia nudicatiis A. O 98.5 Guizotia abyssinica A. O 94.8 Arctii in minus A. R 24.6 Hamamelis virginiana A. R 91.8 Arctii in minus A. O 67.9 Hedeona ptilegioides A. O 93.3 Arctostaphylos tiva-lisi A. R 75.1 Helleborus niger A. O 82.9 Arctostaphylos tiva-lisi A. O 89.8 Hordeum hexastichon A. R 26.9 Armoracia rusticana A. O 92.3 Hyssopus officinalis A. R 40.2 Aronia melanocarpa A. O 60.1 Initia heienium A. O 86.O Aronia melanocarpa A. R 61.6 Ipomoea Batatas A. R 25.6 Aronia melanocarpa A. O 82.3 Lathyrus Saivais A. R 26.9 Artemisia Absinthium A. R 88.6 Lathyrus Saivais A. O 84.9 Artemisia dracunculus A. O 55.6 Lathyrus Sylvestris A. R 22.4 Aster sp A. R 50.7 Lathyrus Sylvestris A. O 93.4 Atropa belladonna A. O 89.4 Latiri is nobilis A. O 642 Beckmannia eruciformis A. R 86.0 Latiri is nobilis A. R 64.6 Beckmannia eruciformis A. O 96.2 Leonirits cardiaca A. O 90.0 Beta vulgaris A. R 69.3 Levisticum officinale A. R 49.4 Beta vulgaris A. O 87.6 Levisticum officinale A. O 53.3 Beta vulgaris ssp. Maritina A. R 53.7 Lotus corniculatus A. R 674 Beta vulgaris ssp. Maritina A. O 84.2 Lotus corniculatus A. O 98.8 Borago officinalis A. O 38.6 Lycopersicon escientiin A. R 30.1 Brassica naptis A. R 43.5 Malva Sylvestris A. O 82.3 Brassica naptis A. O 84.4 Medicago Saiiva A. R 44.0 Brassica oleracea A. O 60.6 Medicago Saiiva A. O 94.4 Brassica rapa A. R 62.1 Meilotus aibus A. R 80.7 Brassica rapa A. O 98.9 Meilotus aibus A. O 98.9 US 2009/0263516 A1 Oct. 22, 2009 68

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Melissa officinalis A. O 89.4 Soianum tuberosum A. O 79.8 Melissa officinalis A. R 93.6 Solidago Sp A. R 43.7 Mentha piperita A. O 60.1 Solidago Sp A. O 72.1 Mentha piperita A. R 60.8 Sonchi is oleracetis A. R 21.6 Menthapulegitim A. O SS.4 Sonchi is oleracetis A. O 92.4 Mentha spicaia A. O 97.0 Sorghum dochna A. O 60.9 Mentha suaveolens A. O 46.8 Sorghum durra A. O 89.3 Nepeta Cataria A. R 32.6 Stachys affinis A. R 29.3 Nepeta Cataria A. O 67.2 Stachys byzantina A. R 28.3 Nicotiana tabacum A. R 34.1 Stellariagraminea A. R 49.9 Oenothera biennis A. R 48.5 Stellariagraminea A. O 87.6 Oenothera biennis A. O 834 Steiaria media A. R 25.7 Origantin majorana A. O 63.2 Steiaria media A. O 26.0 Origantim vulgare A. R 62.2 Tanacetain parthenium A. R 64.6 Origantim vulgare A. O 90.0 Tanacetum vulgare A. R 36.0 Panax quinquefolius A. O 32.3 Tanacetum vulgare A. O 85.7 Panax quinquefolius A. R 75.9 Taraxacum officinale A. R 36.9 Panicum miliaceum A. R 25.6 Taraxacum officinale A. O 1OOO Panicum miliaceum A. O 45.1 Teucrium chamaedrys A. O 92.5 Pastinaca Saiiva A. O 1OOO Thymus praecox. Subsp. arcticus A. O SO.1 Petasitesiaponicus A. O 82.7 Thymus serpyllum A. R 27.3 Petroselinum crispum A. R SO.2 Thymus serpyllum A. O 88.9 Petroselinum crispum A. O 85.7 Thymus vulgaris A. R 60.9 Petroselinum crispum A. O 92.2 Thymus vulgaris A. O 74.3 Phaiaris canariensis A. R 89.5 Thymus X citriodorus A. O 80.9 Phaseolus vulgaris A. R 22.1 Tragopogon porrifolius A. R 43.2 Phaseolus Vulgaris A. O 90.3 Tragopogon porrifolius A. O 819 Pimpinella anisum A. O 724 Tropaeoluim maints A. R 42.6 Plantago major A. R 22.2 Tropaeoluim maius A. O 82.6 Plantago major A. O 99.8 Typha latifolia A. O 49.5 Plectranthus sp. A. R 73.5 Typha latifolia A. R 65.4 Potentiiia anserina A. O 92.9 Vaccinium Corymbosum A. O 94.5 Pteridium aquilinum A. O 819 Vaccinium macrocarpon A. O 94.1 Raphantis raphanistrain A. O 70.2 Veratrum viride A. O 78.4 Raphantis sativits A. R 28.4 Verbascum thapsus A. O 96.4 Raphantis sativits A. O 99.0 Vicia Saiva A. O 98.7 Rheum rhabarbarium A. R 21.4 Vicia viliosa A. R 29.0 Rheum rhabarbarium A. O 95.6 Vicia viliosa A. O 97.6 Ribes nigrum A. R 59.3 Vinca minor A. O 74.6 Ribes nigrum A. O 81.8 Vitis sp. A. R 82.1 Ribes Sylvestre A. O 98.6 Vitis sp. A. O 99.5 Ricinits communis A. R 78.5 Zea mayS A. R 24.4 Ricinits communis A. O 90.2 Zea mayS A. O 99.2 Rosa rugosa A. R 36.1 Achillea millefolium G O 42.8 Rubus allegheniensis A. O 59.3 Aconium napeiitis G O 37.1 Rubus Canadensis A. O 94.4 Acorus calamus G O 89.0 Rubus idaeus A. R 58.4 Actinidia argutta G R 35.5 Rubus idaeus A. O 97.4 Actinidia argutta G O 45.4 Rumex Acetosa A. O 83.9 Adiantum pedatum G O 2SO Rumex acetoseiia A. R 46.7 Agropyron repens G O 98.2 Rumex acetoseiia A. O 90.9 Aichemia nois G O 65.5 Rumex crispiis A. R 32.9 Aichemia nois G R 88.9 Rumex crispiis A. O 91.8 Allium ampeioprastin G R 39.0 Rumex Scittatus A. O 94.9 Allium ampeioprastin G O 53.8 Rita graveolens A. O 92.5 Allium cepa G R 35.6 Salix purpurea A. O 44.8 Allium cepa G O 75.1 Salix purpurea A. R 68.1 Aium sativum G O 82.4 Salvia elegans A. O 642 Allium Schoenoporastin G O 88.7 Salvia officinalis A. O 67.8 Aium tuberosum G O 80.3 Salvia officinalis A. R 85.4 Aloe vera G R 28.8 Saivia Sciarea A. O 61.O althaea officinalis G O 94.5 Santolina Chamaecyparissus A. R 54.1 Amaranthus retroflexus G R 35.3 Santolina Chamaecyparissus A. O 63.1 Amaranthus retroflexus G O 73.8 Satureia montana A. O 75.6 Anethlin graveolens G O 52.O Scorzonera hispanica A. O 62.7 Angelica archangelica G R 39.0 Scutellaria laterifiora A. O 82.7 Angelica archangelica G O 80.6 Senecio vulgaris L. A. R 80.9 Apium graveolens G R 37.7 Setaria itaica A. R 3O.O Apium graveolens G O 83.9 Setaria itaica A. O 66.2 Aralia nudicatiis G O 86.7 Siim Sisartin A. R 3O.O Aralia nudicatiis G R 89.5 Siim Sisartin A. O 93.3 Arctii in minus G R 27.1 Soianum tuberosum A. R 30.1 Arctii in minus G O 93.4 US 2009/0263516 A1 Oct. 22, 2009 69

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Arctostaphylos tiva-lisi G R 73.3 Guizotia abyssinica G R 41.5 Armoracia rusticana G O 53.8 Guizotia abyssinica G O 95.4 Aronia melanocarpa G R 73.2 Hamamelis virginiana G O 79.7 Aronia melanocarpa G O 81.2 Hamamelis virginiana G R 90.8 Artemisia absinthium G R 92.0 Heianthus strumosus G R 31.7 Artemisia dracunculus G R 36.0 Heianthus strumosus G O 39.4 Artemisia dracunculus G O 72.7 Heianthus tuberosus G R 31.5 Asclepias incarnata G R 674 Heianthus tuberosus G O 70.6 Asclepias incarnata G O 87.O Helichrysum thianschanicum G R 40.4 Asparagus officinalis G O 98.2 Helichrysum thianschanicum G O 69.2 Aster G O 37.4 Helleborus niger G R 43.8 Aster sp G R 37.3 Helleborus niger G O 90.6 Aster sp G O 813 Hordeum hexastichon G R 22.6 Beckmannia eruciformis G O 90.0 Hordeum hexastichon G O 86.0 Beta vulgaris G O 29.0 Hyssopus officinalis G R 25.8 Beta vulgaris G R 71.5 Initia heienium G O 82.2 Borago officinalis G O 36.4 Lactica Saiiva G R 28.5 Brassica naptis G R 26.6 Lactica Saiiva G O 95.5 Brassica naptis G O 98.8 Lathyrus Sylvestris G R 22.1 Brassica oleracea G O 97.8 Lathyrus Sylvestris G O 79.5 Brassica rapa G R 25.3 Latiri is nobilis G R 49.6 Brassica rapa G O 67.8 Latiri is nobilis G O 72.3 Calamagrostis artindiflora G R 23.2 Lavandhiia anglisiifolia G O 57.6 Campaniiia raptinctius G O 80.2 Lavandhiia anglisiifolia G R 65.2 Canna eduis G R 31.6 Ledum groenlandictim G R 35.1 Canna eduis G O 44.2 Ledum groenlandictim G O 97.9 Capsella bursa-pastoris G R 63.0 Leonirits cardiaca G O 99.9 Capsella bursa-pastoris G O 69.5 Levisticum officinale G R 75.1 Cartin carvi G O 32.3 Levisticum officinale G O 92.5 Chaerophyllum bulbosum G R 30.7 Lotus corniculatus G R 25.7 Chaerophyllum bulbosum G O 38.0 Lotus corniculatus G O 98.5 Chelidonium maius G O 91.3 Lupinus polyphyllius G O 94.5 Cicer arietintin G R 44.7 Lupinus polyphyllius G R 99.9 Cicer arietintin G O 92.7 Lycopersicon escientiin G R 70.O Cichorium endivia subsp. Endivia G O 94.9 Lycopersicon escientiin G O 90.2 Cichorium intybus G R 25.8 Maius hupehensis G R 44.8 Cichorium intybus G O 95.8 Maius hupehensis G O 82.9 Circium arvense G O 73.0 Medicago Saiiva G R 26.2 Circium arvense G R 96.5 Medicago Saiiva G O 99.2 Coix Lacryma-Jobi G O 57.4 Meilotus aiba G R 96.9 Cornus Canadensis G O 62.5 Meilotus aiba G O 99.0 Cornus Canadensis G R 68.0 Melissa officinalis G O 33.2 Crataegus Suibnois G O 58.3 Melissa officinalis G R 90.6 Crataegus Suibnois G R 73.2 Mentha piperita G O 4.1.8 Cymbopogon citratus G R 65.5 Menthapulegitim G O 38.7 Cymbopogon citratus G O 70.9 Mentha spicaia G R 32.7 Cypertis escientiis G O 8S.O Mentha spicaia G O 80.1 Daiiciis Caroia G R 23.3 Mentha suaveolens G O 55.7 Daiiciis Caroia G O 57.3 Nepeta Cataria G R 93.1 Dirca palustris G R 67.1 Ocimum basilicum G O 75.6 Dirca palustris G O 97.2 Oenothera biennis G R 42.9 Dryopteris filix-mas G O 52.2 Oenothera biennis G O 86.1 Echinacea purpurea G O 744 Origantin majorana G O 65.8 Eleusine coracana G R 38.7 Origantim vulgare G O 89.6 Eleusine coracana G O 76.8 Origantim vulgare G R 92.3 Erigeron speciosus G R 26.8 Oryza Sativa G O 95.6 Erysimum perofskianum G R 59.8 Oxalis Deppei G O 86.8 Erysimum perofskianum G O 10O2 Oxalis Deppei G R 87.8 Fagopyrim esculenium G R 37.6 Oxyria digyna G R 20.8 Fagopyrim tariarictim G O 27.3 Oxyria digyna G O 89.3 Fagopyrim tariarictim G R 30.7 Panax quinquefoils G R 52.7 Gainsoga ciliata G O 30.9 Panicum miliaceum G R 31.5 Gainsoga ciliata G R 51.3 Panicum miliaceum G O 94.4 Gaium odoratum G O 96.9 Passiflora caerulae G R 21.1 Gaultheria hispidula G R 70.9 Passiflora caerulae G O 60.6 Gaultheria hispidula G O 82.2 Pastinaca Saiiva G O 72.8 Gaultheria procumbens G O 69.6 Pennisetum alopectiroides G R 30.6 Giechona hederacea G O 94.0 Petasitesiaponicus G O 81.6 Glycine max G R 76.1 Petroselinum crispum G R 62.9 Glycine max G O 1OOO Petroselinum crispum G O 76.3 Glycyrrhiza glabra G R 33.3 Phaiaris canariensis G O 22.O Glycyrrhiza glabra G O 94.5 Phaiaris canariensis G R 36.7 US 2009/0263516 A1 Oct. 22, 2009 70

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Phaseolus vulgaris G R 65.5 Steiaria media G R 27.9 Phaseolus vulgaris G O 88.2 Steiaria media G O SO.O Pimpinella anisum G O 46.2 Symphytum officinale G O 43.5 Pistin Saivain G O 52.5 Symphytum officinale G R 74.2 Plantago major G R 29.0 Tanacetum cinerariifolium G O 72.2 Plantago major G O 96.3 Tanacetain parthenium G R 67.9 Plectranthus sp. G R 54.5 Tanacetum vulgare G R 49.5 Polygonum aviculare G O 29.6 Tanacetum vulgare G O 97.8 Portuiaca oierracera G R SO.9 Taraxacum officinale G R 45.4 Potentiiia anserina G O 92.5 taraxacum officinale G O 1OOO Poterium sanquisorba G O 74.2 Teucrium chamaedrys G R 61.7 Prunella vulgaris G O 77.1 Teucrium chamaedrys G O 89.8 Prunella vulgaris G R 91.8 Thymus fragantissinus G O 64.O Pteridium aquilinum G O 87.5 Thymus fragantissinus G R 85.4 Rhaphants sativits G R 24.0 Thymus praecox. Subsp. arcticus G R 28.3 Rhaphants sativits G O 8S.O Thymus praecox. Subsp. arcticus G O 39.1 Rheum rhabarbarium G R 22.9 Thymus serpyllum G R 28.4 Rheum rhabarbarium G O 85.5 Thymus serpyllum G O 90.3 Ribes nidigrolaria G O 59.7 Thymus vulgaris G R 69.0 Ribes nigrum G O 804 Thymus vulgaris G O 70.6 Ribes nigrum G R 81.5 Thymus X citriodorus G O 70.7 Ribes Sylvestre G O 91.7 Tiarella cordifolia G O 88.4 Ricinits communis G R 27.0 Tropaeii in maints G O 76.8 Ricinits communis G O 98.3 Typha latifolia G O 76.4 Rosmarinus officinalis G O 27.5 Typha latifolia G R 82.9 Rubus idaeus G R 38.7 Vaccinium corymbosum G R 72.1 Rubus idaeus G O 51.2 Vaccinium corymbosum G O 95.4 Rumex crispiis G R 37.1 Vaccinium macrocarpon G O 95.3 Rumex crispus G O 95.0 Veratrum viride G O 80.8 Rumex Scittatus G O 88.5 Verbascum thapsus G R 27.3 Rita graveolens G R 46.4 Verbascum thapsus G O 91.3 Rita graveolens G O 846 Viburnum trilobum G O 68.5 Salix purpurea G O 32.4 Viburnum trilobum G R 72.6 Salix purpurea G R 95.3 Vicia Saiva G R 32.2 Salvia elegans G O 57.0 Vicia Saiva G O 96.8 Salvia officinalis G O 65.8 Vicia viliosa G R 29.7 Salvia officinalis G R 94.9 Vicia viliosa G O 98.7 Saivia Sciarea G O 58.5 Vinca minor G O 35.8 Sambucus ebulus G R 32.1 Vitis sp. G R 77.5 Sambucus ebulus G O 67.7 Vitis sp. G O 99.8 Santolina Chamaecyparissus G R 49.3 Zea mayS G O 54.2 Saponaria officinalis G R 22.3 Zea mayS G R 56.0 Saponaria officinalis G O 88.5 Achillea millefolium O 89.0 Satureia hortensis G O 73.3 Aconium napeiitis O 63.6 Satureia montana G O 74.8 Acorus calamus O 94.2 Scorzonera hispanica G R 43.1 Actinidia argutta R 52.4 Scorzonera hispanica G O 52.1 Actinidia argutta O 84.8 Scutellaria laterifiora G O 92.0 Adiantum pedatum O 92.2 Secale cereale G R 23.7 Agrimonia eupatoria O 39.2 Senecio vulgaris G R 29.1 Agropyron rupens O 97.3 Setaria itaica G R 21.9 Aichemia nois O 85.2 Setaria itaica G O 83.2 Aichemia nois R 96.8 Silene vulgaris G R 24.1 Allium ampeioprastin R 33.5 Siim Sisartin G R 37.9 Allium ampeioprastin O 94.1 Siim Sisartin G O 1OOO Allium cepa R 544 Soianum melongena G R 22.7 Allium cepa O 1OOO Soianum tuberosum G R SO.2 Aium sativum O 76.5 Soianum tuberosum G O 73.3 Allium Schoenoprastin O 87.O Solidago sp G R 32.9 Aium tuberosum R S3.6 Solidago sp G O 87.3 Aium tuberosum O 98.7 Sonchi is oleracetis G R 37.8 Aloe vera R 43.7 Sonchi is oleracetis G O 48.1 Aloe vera O 79.9 Sorghum dochna G R 43.1 Althaea officinalis O 95.8 Sorghum dochna G O 91.3 Amaranthus caudathus R 20.7 Sorghum durra G R 56.4 Amaranthus caudathus O 69.3 Sorghum durra G O 63.2 Amaranthus retroflexus R 32.4 Sorghum Sudanense G R 56.1 angelica archangelica R 44.2 Sorghum Sudanense G O 89.7 angelica archangelica O 55.7 Stachys Affinis G R 27.9 Anthriscus cerefolium O 96.1 Stachys byzantina G R 42.8 Apium graveolens R 30.3 Stachys byzantina G O 72.1 Aralia nudicatiis R 68.2 Stellaria graminea G R 39.7 Aralia nudicatiis O 97.8 US 2009/0263516 A1 Oct. 22, 2009 71

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Arctii in minus O 92.9 Foeniculum vulgare O 21.0 Arctostaphylos tiva-lisi O 72.O Fpomoea batatas O 98.6 Arctostaphylos tiva-lisi R 79.8 Fragaria Xananassa O 44.3 Armoracia rusticana O 88.0 Gainsoga ciliata R 49.4 Aronia melanocarpa R 74.9 Gainsoga ciliata O 56.9 Aronia melanocarpa O 80.0 Gaium odoratum R 59.4 Artemisia absinthium O 41.7 Gaium odoratum O 95.3 Artemisia absinthium R 96.1 Gaultheria hispidula R 37.9 Artemisia dracunculus O 96.2 Gaultheria hispidula O 78.5 Artium lappa O 21.1 Gaultheria procumbens O 85.7 Asclepias incarnata O 81.5 Giechona hederacea O 95.9 Asclepias incarnata R 86.7 Glycine max O 96.8 Aster O 34.1 Glycine max R 32.8 Aster sp R 46.8 Glycine max O 1OOO Aster sp O 49.7 Glycyrrhiza glabra R 70.2 Atropa belladonna O 71.7 Glycyrrhiza glabra O 90.3 Avena Saiiva R 40.4 Guizotia abyssinica R 34.4 Beta vulgaris O 30.6 Guizotia abyssinica O 97.9 Beta vulgaris R 41.7 Hamamelis virginiana R 72.1 Borago officinalis R 59.2 Hamamelis virginiana O 77.1 Borago officinalis O 76.5 Hedeona ptilegioides O 34.7 Brassica naptis R 35.8 Heianthus strumosus R 20.6 Brassica Naptis O 91.9 Heianthus strumosus O 57.2 Brassica nigra R 24.3 Heianthus tuberosa O 61.O Brassica oleracea O 83.8 Heianthus tuberosus R 46.9 Bronts inermis O 69.6 Helichrysum angustifolium O 23.5 Bronts inermis R 912 Helichrysum angustifolium R 94.5 Calendula officinalis R 34.5 Helichrysum thianschanicum R 98.1 Canna eduis R 2O.S Helleborus niger O 26.2 Canna eduis O 73.5 Huntilus lupulus R 38.0 Capsella bursa-pastoris R 32.1 Huntilus lupulus O 93.8 Capsella bursa-pastoris O 75.1 Hyoscyami is niger O 41.5 Carex morrowii R 44.0 Hyssopus officinalis R 44.6 Carex morrowii O 94.3 Initia heienium O 97.6 Cartin carvi R 2O.S Juniperus communis R 8O.O Cerastii in to mentostin R 36.8 Koeleria giatica O 94.7 Chaerophyllum bulbosum R 23.0 Koeleria giatica R 99.4 Chaerophyllum bulbosum O 80.2 Lactica Saiiva O 94.0 Chelidonium maius O 94.3 Lathyrus Saiivus R 24.0 Chenopodium quinoa O 48.2 Lathyrus Saiivus O 33.0 Chenopodium quinoa R 48.3 Lathyrus Sylvestris O 43.1 Cicer arietintin R 25.6 Latiri is nobilis R 51.7 Cicer arietintin O 81.7 Latiri is nobilis O 87.2 Cichorium endivia subspendivia R 20.8 Lavandhiia iaiifolia R 75.5 Cichorium endivia subspendivia O 95.5 Lavendula angustifolia R 819 Cichorium intybus R 20.4 Ledum groenlandictim R 45.9 Cichorium intybus O 96.O Ledum groenlandictim O 99.5 Circium arvense R 58.3 Lens culinaris Subsp. Culinaris R 28.0 Circium arvense O 79.6 Lens culinaris Subsp. Culinaris O 97.6 Citrulius colocynthis R 41.2 Levisticum officinale R 514 Citrulius colocynthis O 84.9 Levisticum officinale O 87.8 Coriandrum sativum O 38.4 Lotus corniculatus R 53.7 Coriandrum sativum R 48.8 Lotus corniculatus O 97.4 Cornus Canadensis O 32.1 Lupinus polyphyllius O 95.8 Cornus Canadensis R 80.2 Lupinus polyphyllius R 99.3 Crataegus sp R 22.9 Luzula sylvatica R 29.5 Crataegus Suibnois O 81.5 Maius hupehensis R 58.7 Cryptotaenia Canadensis R 20.9 Maius hupehensis O 62.5 Cymbopogon citratus R 4O.S Maius spp. O 25.7 Cymbopogon citratus O 77.0 Malva Sylvestris O 73.5 Cypertis escientiis R 20.9 Medicago Saiiva R 46.2 Cypertis escientiis O 72.O Medicago Saiiva O 94.9 Dirca palustris R 67.1 Melilotus officinalis O 99.4 Dirca palustris O 82.2 Melissa officinalis R 91.0 Dryopteris filix-mas O 23.9 Mentha piperita O 86.8 Echinacea purpurea O 92.2 Menyanthes trifoliata O 64.3 Eleusine coracana R 3O.O Miscanthus sinensis Andress R 36.1 Erysimum perofskianum R 81.7 Miscanthus sinensis Andress O 66.6 Erysimum perofskianum O 98.8 Nepeta Cataria O 23.6 Fagopyrim esculenium O 35.5 Ocimum Basilicum O 813 Fagopyrim tararictim O 40.0 Oenothera biennis R 35.7 Fagopyrim tatarictim R 30.1 Oenothera biennis O 75.6 US 2009/0263516 A1 Oct. 22, 2009 72

TABLE 9-continued TABLE 9-continued

Cath K Cath K

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Onobrychis viciifolia R 44.5 Satureia repandra R 49.7 Onobrychis viciifolia O 90.7 Satureia repandra O 73.3 Origantim vulgare R 76.5 Scorzorera hipanica O 6.3.3 Origantim vulgare O 82.9 Scuttellaria laterifiora O 29.3 Oryza sativa O 514 Setaria itaica R 20.8 Oxalis Deppei R 48.4 Silene vulgaris O 96.8 Oxalis Deppei O 734 Siim Sisartin R 27.4 oxyria digyna R 23.6 Siim Sisartin O 88.8 oxyria digyna O 92.5 Soianum melongens R 21.9 Panax quinquefolius O 24.8 Solidago Sp R 45.9 Panax quinquefolius R 36.6 Solidago Sp O 74.O Panicum miliaceum R 26.9 Sonchi is oleracetis R 22.7 Passiflora caerulea R 55.3 Sonchi is oleracetis O 38.1 Passiflora caerulea O 77.6 Sorghum cafiorum O 57.0 Pastinaca Saiiva O 49.2 Sorghum cafiorum R 74.O Pastinaca Saiiva O 82.9 Sorghum dochna O 44.3 Pennisetum alopectiroides O 74.9 Sorghum dochna O 65.8 Perilla frutescens R 83.5 Sorghum dochna R 70.7 Petasites Japonicus R 22.9 Sorghum dochna R 89.0 Petasites Japonicus O 79.5 Sorghum durra R 39.6 Petroselinum crispum O 61.1 Sorghum durra O 76.5 Petroselinum crispum O 83.7 Sorghum Sudanense O 4.O.S Petroselinum crispum R 99.0 Stachys affinis R 67.2 Phaiaris canariensis R 29.5 Stachys affinis O 86.6 Phaiaris canariensis O 67.2 Stachys byzantina R 85.7 Phaseolus vulgaris O 93.1 Stellariagraminea O 43.3 Physalis pruinosa O 64.2 Stellaria graminea inne R 39.2 Pimpinella anisum R 59.0 Steiaria media R 21.1 Pimpinella anisum O 88.5 Stipa capillata R 24.2 Pistin Saivain O 75.4 Symphytum officinale R 64.4 Plantago major O 99.6 Tanacetain parthenium R 62.2 Plectranthus sp. R 49.4 Tanacetum vulgare R 42.5 Podophyllum peltatum O 87.3 Tanacetum vulgare O 97.5 Polygonum aviculare R 32.8 Taraxacum officinale R 47.5 Polygonum aviculare O 53.9 Taraxacum officinale O 1OOO Potentiiia anserina O 94.9 Teucrium chamaedrys R 40.O Prunella vulgaris O 76.4 Thymus fragantissinus O 93.7 Prunella vulgaris R 94.7 Thymus fragantissinus R 97.3 Pteridium aquilinum O 90.1 Thymus praecox. Subsp. arcticus O 46.0 Raphantis raphanistrain R 39.5 Thymus pseudoianuginostis R 74.3 Raphantis raphanistrain O 91.O Thymus serpyllum O 886 Raphantis sativits O 79.1 Thymus X citriodorus R 66.4 Ribes nigrum R 89.6 Thymus X citriodorus O 97.8 Ribes nigrum O 95.4 Tiarella cordifolia O 94.9 Ribes Sylvestre R 20.1 Tragopogon porrifolius R 4S.O Ribes Sylvestre O 97.4 Tragopogon porrifolius O 72.0 Ricinits communis R 26.5 Triticosecale spp R 27.8 Ricinits communis O 92.4 Triticosecale spp O 87.8 Rosa rugosa O 41.6 Trictim aestivum R 26.6 Rubus Canadensis O 96.4 Trictim aestivum O 42.6 Rubus idaeus R 44.8 Tropaeoluim maints R 21.4 Rubus idaeus O 88.7 Tropaeoluim maints O 81.5 Rimes Scittatus O 88.7 Typha latifolia O 44.8 Rumex acetoseiia R 40.9 Typha latifolia R 72.5 Rumex acetoseiia O 90.9 Urtica dioica R 35.2 Rumex crispiis R 33.4 Urtica dioica O 62.9 Rumex crispiis O 89.3 Vaccinium anglisiifolium R 27.4 Rita graveolens O 68.5 Vaccinium macrocarpon R 78.0 Salix purpurea R 37.1 Vaccinium macrocarpon O 87.8 Salix purpurea. O 46.1 Veratrum viride O 90.2 Salvia officinalis O 67.7 Verbascum thapsus O 84.3 Salvia officinalis R 91.1 Viburnum trilobum R 45.2 Sambucus Canadensis R 35.7 Viburnum trilobum O 7O.O Sambucus Canadensis O 99.0 Sanguisorbagif minor O 90.6 Vicia Saiva O 99.0 Santoina O 62.7 Vicia viliosa R 44.2 Santoina R 734 Vicia viliosa O 98.3 Saponaria officinalis O 93.2 Vinca minor O 21.5 Satureia hortensis R 43.1 Vitis sp. O 99.9 Satureia hortensis O 87.9 Zea mayS R 31.7 Satureia montana R 55.1 Zea mayS O 90.2 Satureia montana O 79.2 US 2009/0263516 A1 Oct. 22, 2009 73

TABLE 10 TABLE 10-continued

HLE HLE

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition

Achillea millefolium A. O 21.9 Cucumis meio A. S S3.6 Achillea millefolium A. S 24.5 Ciclinissativits A. R 53.3 Aconium napelius A. O 25.8 Curcuna Zedoaria A. O 24.3 Adiantum pedatum A. R 27.6 Cymbopogon citratus A. S 91.2 Agrimonia eupatoria A. V 26.0 Datisca cannabina A. S 55.7 Agropyron cristatum A. R 21.0 Daiiciis Caroia A. R 1OOO Agropyron repens A. S 23.4 Daiiciis Caroia A. V 24.7 Agropyron repens A. R 28.2 Daiiciis Caroia A. O 37.9 Agropyron repens A. S 39.8 Digitalis purpurea A. S 34.0 Agrostis Siofonifera A. O 38.9 Dirca palustris A. R 20.3 Aichemia nois A. V 27.9 Dirca palustris A. S 27.9 Aichemia nois A. O 66.O Doichos Labiah A. R 21.5 Aichemia nois A. R 1OOO Dryopteris filix-mas A. R 58.8 Aichemia nois A. S 23.5 Dryopteris filix-mas A. S 22.0 Aikanna tinctoria A. S 26.2 Echinacea purpurea A. O 38.2 Aium Tuberosum A. S 57.9 Echinacea purpurea A. S 28.1 Aloe Vera A. O 2O.S Eleusine Coracana A. S 20.7 Ambrosia artemisiifolia A. O 29.1 Erigeron Canadensis A. O 29.6 Amelanchier sanguinea A. W 96.5 Fagopyrim esculenium A. S 29.3 Amelanchier sanguinea A. V 52.4 Fagopyrim tatarictim A. S 24.4 Anethtingraveolens A. O 32.1 Foeniculum vulgare A. O 25.1 Anethtingraveolens A. W 22.8 Fragaria Xananassa A. O 22.3 Angelica archangelica A. S 39.2 Fragaria Xananassa A. W 1OOO Anthemis nobilis A. O 37.6 Fragaria Xananassa A. V 21.4 Anthemis nobilis A. S 26.4 Fragaria Xananassa A. S 29.4 Anthemistinctoria A. O 31.9 Fragaria Xananassa A. V 21.6 Anthemistinctoria A. S 38.4 Gainsoga ciliata A. R 61.6 Apium graveolens A. S 49.2 Gaium odoratum A. R 21.0 Arctii in minus A. O 46.4 Gaultheria hispidula A. O 33.7 Arctostaphylos tiva-lisi A. R 1OOO Gentiana lutea A. R 52.1 Aronia melanocarpa A. O 21.9 Giechona hederacea A. O 21.8 Aronia melanocarpa A. W 78.4 Glycine Max A. S 813 Aronia melanocarpa A. V 1OOO Glycyrrhiza glabra A. W 1OOO Aronia melanocarpa A. R 29.0 Glycyrrhiza glabra A. S 6.3.3 Aronia melanocarpa A. O 33.6 Guizotia abyssinica A. R 36.9 Artemisia dracunculus A. W 89.2 Hamamelis virginiana A. R 1OOO Aster sp A. R 26.2 Heianthus Tiberosus A. S 32.1 Beta vulgaris A. R 1OOO Heliotropium arborescens A. R 22.8 Beta vulgaris ssp. Maritina A. R 92.2 Heliotropium arborescens A. S 24.9 Borago officinalis A. S 22.6 Helleborus niger A. S 25.6 Brassica naptis A. S 68.3 Hordeum vulgare A. O S8.1 Brassica naptis A. R 29.5 Hyperictim perforatin A. S 24.8 Brassica nigra A. S 32.6 Hyssopus officinalis A. O 21.1 Brassica oleracea A. O 22.9 Hyssopus officinalis A. S 93.6 Brassica oleracea A. V 20.8 Lactuca seriola A. S 34.3 Brassica oleracea A. R 22.2 Latiri is nobilis A. W 1OOO Brassica rapa A. S 23.2 Lavandhiia iaiifolia A. W 57.1 Brassica rapa A. R 26.9 Lavandhiia iaiifolia A. O 43.7 Bronts inermis A. O 34.1 Lavandhiia iaiifolia A. S 42.2 Bronts inermis A. R 21.9 Leonirits cardiaca A. R 1OOO Calamintha nepeta A. O 35.4 Lepidium sativum A. O 1OOO Canna eduis A. O 56.4 Lolium multiflorum A. O 31.0 Canna eduis A. R 21.4 Lolium perenne A. O 20.8 Cartin carvi A. O 24.2 Lolium perenne A. R 21.7 Chaerophyllum bulbosum A. O 25.5 Lolium perenne A. S 22.1 Chenopodium bonus-henricus A. R 24.0 Ludoviciana A. O 33.4 Chenopodium bonus-henricus A. S 85.8 Ludoviciana A. S 20.7 Chenopodium quinoa A. S SO4 Malva Sylvestris A. S 22.9 Chrysanthemum coronarium A. O 26.0 Matricaria recitita A. O 28.5 Cicer arietintin A. S 23.3 Melaleuca alternifolia A. O 21.9 Cichorium intybus A. S 32.1 Melissa officinalis A. S 23.4 Citritius ianatus A. R 26.3 Mentha piperita A. O 31.6 Coix Lacryma-Jobi A. S 66.1 Mentha piperita A. W 33.2 Cosmos sulphureus A. O 38.8 Menthapulegitim A. O 42.2 Cosmos sulphureus A. S 20.7 Menthapulegitim A. V 21.5 Crataegus sp A. O 84.1 Menthapulegitim A. S 33.8 Crataegus sp A. R 23.6 Mentha spicaia A. O 24.3 Crataegus sp A. S 21.7 Oenothera biennis A. O 25.2 Crataegus Suibnois A. S 34.0 Oenothera biennis A. R 78.8 Cryptotaenia Canadensis A. V 22.1 Origantin majorana A. V 37.4 Cuctimis anguria A. O 26.2 Oxyria digyna A. V 28.2 Cuctimis Anguria A. R 53.4 Panicum miliaceum A. O 33.3 US 2009/0263516 A1 Oct. 22, 2009 74

TABLE 10-continued TABLE 10-continued

HLE HLE

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Peucedanum cervaria A. R 23.4 Teucrium chamaedrys A. O 37.0 Phaiaris arundinacea A. R 22.4 Thymus fragantissinus A. W 2O2 Phaiaris canariensis A. O 27.8 Thymus herba-barona A. W 20.8 Phaseolus coccineus A. S 28.3 Thymus vulgaris A. R 77.9 Phaseolus mingo A. R 37.8 Thymus vulgaris A. W 23.6 Phaseolus vulgaris A. O 24.3 Thymus X citriodorus A. W 21.3 Phaseolus Vulgaris A. S 74.3 Thymus X citriodorus A. S 21.1 Phleum pratense A. R 27.8 Trichosanthes kirillowii A. O 23.2 Physalis ixocarpa A. O 21.5 Trigonelia foentingraecum A. S 32.O Physalis Ixocarpa A. S 26.5 Triticum durum A. S 22.0 Physalis Pruinosa A. S 6O2 Triticum turgidium A. O 6O.O Phytolacca americana A. S 1OOO Triticum spelta A. S 47.6 Plantago Coronopus A. O 21.1 Urtica dioica A. O 33.3 Plantago Coronopus A. S 25.7 Vaccinium augustifolium A. W 42.6 Plantago major A. O 26.0 Vaccinium Corymbosum A. W 22.4 Plectranthus sp. A. O 23.1 Vaccinium Corymbosum A. S 21.6 Poa pratensis A. O 21.7 Vaccinium macrocarpon A. W 22.5 Polygonum aviculare A. R 79.7 Vaccinium macrocarpon A. S 54.8 Portuiaca oievcae A. O 34.5 Valerianeia locusta A. O 49.2 Poterium sanguisorba A. R 25.8 Veronica officinalis A. O 43.7 Poterium sanguisorba A. O 34.6 Viburnum trilobum Marsh. A. W 75.4 Poterium sanguisorba A. W 31.0 iiis A. S 33.8 Pteridium aquilinum A. R 544 iiis A. W 1OOO Raphantis sativits A. S 66.4 iiis A. O 21.0 Raphantis sativits A. R 81.8 Zea Mays A. S 95.2 Rheum officinale A. S 37.9 Achillea millefolium G O 28.8 Ribes nigrum A. W 1OOO Achillea millefolium G S 27.3 Ribes nigrum A. S 47.6 Aconium napeiitis G O 23.1 Ribes nigrum A. V 27.5 Aconitum napellus G R 97.7 Ribes rubrum A. R 35.4 Acorus calamus G S 2O.O Ribes Sylvestre A. W 1OOO Adiantum pedatum G R 1OOO Rosa rugosa A. W 95.1 Agastache foeniculum G W 25.3 Rosa rugosa A. R 24.6 Ageratum conyzoides G O 28.5 Rosmarinus officinalis A. R 58.4 Agropyron cristatum G R 37.3 Rubus idaeus A. W 27.6 Agropyron repens G R 31.4 Rubus idaeus A. S 33.0 Aichemia nois G W 20.6 Rubus idaeus A. R 27.9 Aichemia nois G O 56.1 Rubus idaeus A. O 37.4 Aichemia nois G R 28.1 Rumex Acetosa A. S 45.2 Aichemia nois G S 25.3 Rumex crispiis A. O 26.1 Allium cepa G O 2O2 Rumex crispiis A. R 1OOO Aium sativum G O 1OOO Rumex Scittatus A. V 43.8 Aium tuberosum G O 1OOO Rita graveolens A. O 28.7 Althaea officinalis G S 30.8 Saccharum officinarum A. O 29.6 Amaranthus caudatus G S 22.3 Saccharum officinarum A. R 23.8 Amelanchier sanguinea G W 88.3 Salvia elegans A. O 1OOO Anethlin graveolens G O 26.2 Salvia officinalis A. O 95.7 Angelica archangelica G S 43.2 Salvia officinalis A. W 77.9 Anthemis nobiis G S 21.7 Salvia officinalis A. R 83.7 Arctostaphylos tiva-lisi G O 33.1 Salvia officinalis A. S 2O.S Arctostaphylos tiva-lisi G R 1OOO Saivia Sciarea A. O 1OOO Arctostaphylos tiva-lisi G S 23.4 Saivia Sciarea A. V 28.6 Armoracia rusticana G O 22.5 Santolina Chamaecyparissus A. O 27.1 Aronia melanocarpa G W 79.0 Satureia montana A. W 23.2 Aronia melanocarpa G V 1OOO Satureia montana A. S 27.7 Aronia melanocarpa G S 22.7 Scorzonera hispanica A. R 60.1 Aronia melanocarpa G O 29.6 Scutellaria laterifiora A. S 45.9 Artemisia absinthium G O 31.5 Senecio vulgaris A. R 34.0 Artemisia absinthium G V 24.2 Sonchi is oleracetis A. O 29.1 Aster G S 29.2 Sorghum dochna A. O 21.1 Beckmannia eruciformis G O 22.7 Sorghum dochna A. V 24.4 Beta vulgaris G R 1OOO Sorghum durra A. O 23.4 Betula glanditiosa G S 26.7 Sorghum durra A. V 23.6 Borago officinalis G O 25.7 Spinacia oleracea A. S 26.8 Brassica Naptis G S SO4 Stellaria graminea A. O 24.8 Brassica naptis G R 48.2 Symphytum officinale A. O 91.6 Brassica nigra G S 23.9 Tanacetum cinerariifolium A. R 28.3 Brassica oleracea G R 28.1 Tanacetum vulgare A. O 46.3 Brassica oleracea G S 22.5 Tanacetum vulgare A. S 33.7 Brassica rapa G R 56.4 Taraxacum officinale A. W 26.4 Calamintha nepeta G V 24.8 Taraxacum officinale A. V 24.0 Calamintha nepeta G O 38.8 Taraxacum officinale A. O 21.0 Canna eduis G O 66.3 US 2009/0263516 A1 Oct. 22, 2009 75

TABLE 10-continued TABLE 10-continued

HLE HLE

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Capsella bursa-pastoris G R 25.8 Lolium perenne G O 37.3 Carthamus tinctorius G R 22.2 Lotus tetragonolobits G S 21.8 Chelidonium maius G O 31.6 Lupinus polyphylius G O 423 Chenopodium album G S 21.3 Maius hupehensis G S 25.9 Cichorium endivia subsp. Endivia G S 21.4 Medicago Saiiva G S 32.1 Cicer arietintin G S 50.7 Melaleuca alternifolia G O 40.O Cichorium endivia subsp. Endivia G O 48.5 Melissa officinalis G S 23.1 Cichorium endivia subsp. Endivia G S 27.9 Mentha arvensis G S 65.5 Coix Lacryma-Jobi G O 24.5 Mentha piperita G O 24.2 Cornus Canadensis G S 36.1 Mentha piperita G S 23.7 Crataegus sp G W 57.8 Mentha piperita G V 34.2 Cucurbita Pepo G R 23.1 Menthapulegitim G O 6.3.3 Curcuna Zedoaria G O 24.0 Menthapulegitim G V 30.2 Datura meiei G O 21.0 Mentha spicaia G S 45.9 Daiiciis Caroia G O 32.3 Monarda didyma G S 47.7 Daiiciis Carroia G R 90.9 Nepeta Cataria G R 1OOO Dipsactis Saivais G O 32.7 Nicotiana tabacum G O 75.8 Dirca palustris G S 33.5 Ocimum basilicum G O 40.1 Doichos Labiah G R 32.1 Ocimum basilicum G S 27.9 Dryopteris filix-mas G R 80.9 Oenothera biennis G O 26.3 Echinacea purpurea G S 63.0 Oenothera biennis G R 1OOO Elymaisincetts G R 25.9 Oenothera biennis G O 49.6 Erigeron Canadensis G O 43.O Oenothera biennis G S S4.O Erigeron speciosus G O 22.8 Origantim vulgare G W 1OOO Erigeron speciosus G S 24.2 Origantim vulgare G O 26.7 Erysimum perofskianum G O 20.8 Origantim vulgare G S 21.3 Fagopyrim esculenium G S 32.9 Oryza Sativa G S 34.5 Fagopyrim tatarictim G S 41.2 Oxalis Deppei Lodd. G O 27.4 Foeniculum vulgare G V 25.7 Panicum miliaceum G O 25.3 Foeniculum vulgare G S 42.5 Pastinaca Saiiva G R 95.0 Foeniculum Vulgare G O 24.1 Petroselinum crispum G R 445 Gainsoga ciliata G S 2SO Petroselinum crispum G S 26.5 Gaium odoratum G R 89.4 Peucedanum cervaria G R 25.1 Gaultheria hispidula G O 35.1 Phaseolus coccineus G R 30.9 Gaultheria hispidula G R 67.2 Phaseolus coccineus G O 27.5 Gaultheria procumbens G S 74.7 Phaseolus mingo G R 24.3 Glycine max G R 24.6 Phlox paniculata G S 37.9 Glycyrrhiza glabra G W 56.8 Physalis pruinosa G S 26.5 Glycyrrhiza glabra G V 3O.O Phytolacca americana G S 1OOO Glycyrrhiza glabra G R 92.4 Pimpinella anisum G S 23.7 Glycyrrhiza glabra G S 28.6 Plantago Coronopus G O 25.1 Hamamelis virginiana G R 1OOO Plantago major G O 2SO Hamamelis virginiana G S 29.3 Plantago major G R 2O.S Hedeona ptilegioides G O 6O.O Plantago major G S 23.6 Helenium hoopesii G O 37.3 Poa compressa G O 28.5 Helenium hoopesii G S 34.7 Poa pratensis G O 37.5 Heianthus tuberosus G V 21.4 Polygonum aviculare G R 25.4 Helichrysum thianschanicum G O 43.O Polygontin pensylvanictim G O 21.3 Helichrysum thianschanicum G R 39.2 Portuiaca oierracea G O 28.0 Heliotropium arborescens G R 22.8 Poterium sanguisorba G O 25.6 Heliotropium arborescens G S 39.5 Poterium sanguisorba G V 21.9 Helleborus niger G S 34.2 Prunella vulgaris G O 23.4 Hordeum vulgare subsp. Vulgare G O 33.4 Pteridium aquilinum G R 43.1 Hypericum hennyi G S 23.7 Reseda Odorata G O 46.5 Hyperictim perforatin G S 23.8 Rhaphanaissativits G S 32.6 Hyssopus officinalis G W 45.1 Rheum x cuitorum G S 20.9 Hyssopus officinalis G S 24.2 Ribes nidigrolaria G W 29.8 Initia heienium G W 96.2 Ribes nidigrolaria G V 53.7 Ipomoia batatas G V 21.9 Ribes nigrum G V 20.3 Lactica Saiiva G W 35.1 Ribes SilveStre G W 91.6 Laportea Canadensis G O 25.1 Ricinits communis G S 46.0 Laportea Canadensis G S 26.5 Rosmarinus officinalis G R 60.4 Laserpitium iaiifolium G S 22.1 Rubus idaeus G W 28.2 Lathyrus Saivais G O 29.9 Rubus occidenia is G R 93.6 Lathyrus Saivais G W 27.8 Rubus occidenia is G O 40.O Lathyrus Saivais G S 28.1 Rumex acetoseiia G V 24.3 Latiri is nobilis G W 1OOO Rumex crispiis G R 1OOO Lavandhiia anguistifolia G O 65.7 Rumex patientia G O 32.O Ledum groenlandictim G O 1OOO Rumex Scittatus G V 28.6 Leonori is cardiaca G R 61.3 Rita graveolens G S 23.4 Lepidium sativum G O 1OOO Saccharum officinarum G O 30.2 Levisticum officinale G W 91.4 Salix purpurea G S 24.8 US 2009/0263516 A1 Oct. 22, 2009 76

TABLE 10-continued TABLE 10-continued

HLE HLE

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Salvia elegans G O 1OOO Aichemia nois S 31.2 Salvia officinalis G W 52.4 Allium ascalonictim S 42.9 Salvia officinalis G R 1OOO Aium sativum O 1OOO Salvia officinalis G O 1OOO Aium tuberosum O 1OOO Saivia Sciarea G O 1OOO Alpinia officinarum O 21.9 Saivia Sciarea G V 23.0 Alpinia officinarum S 1OOO Saivia Sciarea G W 31.1 Amaranthus candatiis S 36.0 Sambucus ebulus G O 52.1 Amaranthus gangeticits S 66.8 Sambucus ebulus G R 48.6 Ananas Conostis O 20.3 Sanguisorba officinalis G R 1OOO Ananas Conostis W 23.8 Santolina Chamaecyparissus G O 1OOO Anethlin graveolens O 35.8 Serrainia tinctoria G S 56.8 angelica archangelica R 53.5 Satureia montana G O 34.1 Anthemis nobiis O 45.3 Scolymits hispanicus G R 37.9 Anthemistinctorium S 47.5 Scutellaria laterifiora G S 54.7 Anthriscus cerefolium O 2O.S Senecio vulgaris G R 35.3 Arctii in minus O 54.1 Solidago sp G S 22.6 Arctostaphylos tiva-lisi O 28.1 Sonchi is oleracetis G O 23.7 Arctostaphylos tiva-lisi R 1OOO Sorghum cafiorum G V 27.1 Aronia melanocarpa V 1OOO Sorghum dochna G S 40.7 Aronia melanocarpa W 42.7 Sorghum dochna G O 21.4 Aronia prunifolia W 39.0 Sorghum Sudanense G V 23.3 Artemisia absinthium O 25.6 Sorghum Sudanense G W 92.9 Artemisia drachinutius O 31.3 Stellaria graminea G O 25.4 Artemisia drachinutius S 22.3 Steiaria media G O 3O4 Aster S 20.9 Steiaria media G R 22.0 Avena Saiiva S 1OOO Tanacetum vulgare G O 57.3 Averrhoa Caramboia O 25.8 Tanacetum vulgare G S 38.4 Beta vulgaris R 1OOO Tanacetum vulgare G O 38.2 Beta vulgaris O 59.3 Tanacetum vulgare G W 26.3 Beta vulgaris S 41.4 Taraxacum officinale G V 2O.O Betula glanditiosa S 618 taraxacum officinale G O 28.0 Boesenbergia rotunda O 36.9 Thymus fragantissinus G R 79.9 Boesenbergia rotunda S 42.5 Thymus fragantissinus G O 26.2 Boietus eduis S 43.1 Thymus herba-barona G W 2O2 Borago officinalis S 36.3 Thymus serpyllum G V 22.2 Brassica hiria S 30.2 Triticosecale spp. G S 29.7 Brassica iuncea R 41.4 Triticum durum G S 37.8 Brassica Naptis S 29.9 Triticum spelta G O 31.0 Brassica naptis R 22.9 Triticum spelta G S 37.9 Brassica oleracea R 25.6 Typha latifolia G S 27.5 Brassica oleracea V 27.0 Urtica dioica G O 60.3 Brassica oleracea R 26.5 Vaccinium corymbosum G S 33.2 Brassica rapa R 24.8 Vaccinium anglisiifolium G S 43.7 Bronts inermis O 27.8 Vaccinium macrocarpon G W 57.8 Canna eduis O 40.3 Vaccinium macrocarpon G S 59.9 Capsicum annium S 22.6 Valerianeia locusta G O 32.1 Carex morrowii O 26.0 Veratrum viride G O 22.1 Carex morrowii R 49.8 Verbascum thapsus G S 33.8 Carya cordiformis S 28.8 Viburnum trilobum G V 21.3 Carya cordiformis O 21.0 Viburnum trilobum G W 73.0 Carya cordiformis W 88.7 Vicia faba G S 21.2 Ciennais armandi O 20.1 Vignatinguiculata G R 20.1 Chaerophyllum bulbosum O 22.8 iiis G V 26.0 Chaerophyllum bulbosum S 24.3 iiis G W 66.1 Agarict is bisporatus S 25.4 iiis G O 41.7 Chelidonium maius O 39.0 iiis G S 30.7 Chenopodium bonus-henricus S 44.3 Xanthium Sibiricum G O 22.1 chrysanthemum coronarium O 33.4 Zea mays G S 20.3 chrysanthemum coronarium S 23.9 Abies lasiocarpa T S 22.4 Cichorium endivia subs. Endivia O 44.3 Achillea millefolium T S 21.1 Cichorium endivia subs. Endivia S 2O.S Aconium napelius T O 1OOO Circium arvense R 49.7 Acorus calamus T S 21.0 Citrulius colocynthis R 37.0 Agarict is bisporatus T S 25.8 Citrulius colocynthis S 35.5 Ageratum conyzoides T O 20.1 Citrus innettoides O 47.1 Agrimonia eupatoria T W 59.6 Citrus innon S 26.2 Agropyron cristatum T R 53.4 Citrus innon O 73.9 Agropyron repens T S 22.6 Citrus reticulata V 32.7 Agrostis alba T O 25.3 Citrus reticulata S 29.4 Aichemia nois T W 88.7 Citrus Sinensis V 25.2 Aichemia nois T O 42.6 Coix Lacryma-Jobi O 32.7 Aichemia nois T R 704 Coix Lacryma-Jobi S 31.4 US 2009/0263516 A1 Oct. 22, 2009 77

TABLE 10-continued TABLE 10-continued

HLE HLE

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Corchorus oitorius O 24.4 Lavandhiia anglisiifolia O 22.7 Cornus Canadensis S 41.3 Lavandhiia anglisiifolia S 25.1 Crataegus sp S 34.0 Lavandhiia iaiifolia O 1OOO Crataegus Suibnois S 39.6 Lavandhiia iaiifolia S 28.5 Circlina longa O 55.3 Ledum groenlandictim O S4.3 Curcuna Zedoaria O 24.4 Lentinus edodes S 25.7 Cydonia oblonga V 35.2 Leonirits cardiaca R 24.3 Cynara Scolymis O 41.2 Lepidium sativum O 1OOO Cynara Scolymis R 36.8 Levisticum officinale R 41.2 Daciis Giomerata O 31.9 Litchi chinensis S 1OOO Datura meiei O 36.9 Lolium multiflorum O 24.0 Datura meiei S 21.4 Lolium perenne O 27.8 Daitira Stranonium S 25.9 Lonicera ranosissina S 20.9 Daiiciis Caroia R 92.3 Lupinus polyphyllius O 35.1 Daiiciis Caroia O 31.0 Lupinus polyphyllius S 2O.S Dipsactis Saivais O 1OOO Luzula sylvatica R 22.6 Dirca palustris S 31.4 Majorana hortensis V 20.1 Doichosiabiah O 23.1 Maius spp. V 37.8 Dryopteris filix-mas R 68.2 Maius spp. S 45.1 Echinacea purpurea S 38.2 Maius hupehensis S 24.4 Eleusine coracana O 22.1 Melaleuca alternifolia O 26.7 Elymaisincetts R 37.9 Melissa officinalis S 20.7 Erigeron speciosus O 3S.O mentha arvensis R 34.0 Erysimum perofskianum O 22.6 Mentha piperita S 60.1 Erysimum perofskianum S 23.2 Menthapulegitim V 24.5 Fagopyrim esculenium S 24.7 Menthapulegitim W 24.8 Foeniculum vulgare O 31.4 Mentha spicaia O 24.4 Foeniculum vulgare V 69.1 Mentha suaveolens S 28.9 Foeniculum vulgare S 38.5 Monarda didyma O 54.7 Fragaria Xananassa O SO4 Musa paradisiaca O 21.4 Fragaria Xananassa V 30.2 Musa paradisiaca W 32.8 Fragaria Xananassa S 28.4 nastairtium officinale O 1OOO Frangiia aints R 65.3 Nepeta Cataria O 60.1 Frangiia aints S 40.7 Nepeta Cataria S 23.4 Fictis vesiculosis O 42.7 Nigella Saiiva S 23.2 Gainsoga ciliata R 49.3 Ocimum Basilicum V 30.7 Gaultheria hispidula W 36.9 Ocimum Basilicum W 30.9 Gentiana macrophylla S 26.1 Ocimum Basilicum O 39.1 Ginkgo biloba V 27.1 Oenothera biennis S 29.6 Glycyrrhiza glabra W S8.1 Oenothera biennis O 24.2 Glycyrrhiza glabra S SO4 Oenothera biennis R 58.6 Glycyrrhiza glabra R 25.1 Onobrychis viciifolia O 42.6 Gossypium herbaceum O 22.7 Origantim vulgare S 53.8 Gossypium herbaceum S 27.3 Oryza sativa S 33.3 Guizotia abyssinica S 38.5 Oxalis Deppei O 30.8 Hamamelis virginiana O 37.1 Panicum miliaceum S 21.2 Hamamelis virginiana R 1OOO Passifiora spp. O 30.2 Hedeona ptilegioides O 28.5 Passifiora spp. V 59.4 Hedeona ptilegioides S 28.2 Passifiora spp. S 24.4 Helenium hoopesii O 31.7 Pastinaca Saiiva S 53.9 Helenium hoopesii S 56.0 Pastinaca Saiiva R 20.8 Heianthus tuberosus V 23.7 Pastinaca Saiiva O 26.9 Helichrysum thianschanicum O 38.4 Petroselinum crispum R 58.2 Helichrysum thianschanicum R 27.0 Phaseolus coccineus S 27.1 Helleborus niger S 32.1 Phaseolus vulgaris W 37.9 Hibiscus cannabinus O 39.9 Phaseolus vulgaris O 22.2 Hibiscus cannabinus S 21.1 Phaseolus vulgaris S 23.2 Huntilus lupulus S 54.8 Phlox paniculata S 21.3 Huntilus lupulus R 50.5 Physalis pruinosa S 35.2 Hydrastis Canadensis O 20.9 Phytolacca americana S 1OOO Hypericum hennyi O 32.5 Plantago Coronopus O 21.2 Hyperictim perforatin S 27.9 Plantago Coronopus S 48.2 Hyperictim sp W 55.9 Pleurotus spp. S 31.6 Hypomyces lactifiutorum S 42.7 Poa pratensis O 50.7 Iberis amara S 1OOO Podophyllum peltatum S 27.9 Initia heienium S 30.1 Polygonum chinense S 2SO Ipomoia batatas V 27.4 Polygonum aviculare O 26.0 Ipomoia batatas S 44.9 Polygonum aviculare R 1OOO Juniperus communis S 57.8 Polygontin pensylvanictim O 423 Laportea Canadensis S 63.5 Polygontin persicaria O 28.8 Latiri is nobilis W 73.6 Populus incrassata S 1OOO Latiri is nobilis S 21.2 Populus Tremula S 48.5 US 2009/0263516 A1 Oct. 22, 2009 78

TABLE 10-continued TABLE 10-continued

HLE HLE

Nom latin Stress Extrait Inhibition Nomlatin Stress Extrait Inhibition Popitius Xpetrowskyana S 44.1 Stachys byzantina O 25.3 Popitius Xpetrowskyana O 1OOO Stellariagraminea O 27.6 Popitius Xpetrowskyana W 72.0 Stellariagraminea S 36.7 Portuiaca oierracera O 33.7 Steiaria media O 22.6 Poterium sanguisorba W 1OOO Stipa capillata O 36.7 Prints spp. S 39.6 Symphytum officinale O 20.6 Prunus persica O 21.4 Symphytum officinale V 2SO Prunus persica V 26.6 Tanacetum cinerariifolium R 24.9 Psidium guaiava V 37.7 Tanacetum vulgare O 46.4 Psidium spp. S 28.3 Tanacetum vulgare S 32.O Psoralea conviifolia S 51.5 Taraxacum officinale O 63.1 Pteridium aquilinum R 76.2 Thlaspi arvense O 32.5 Pteridium aquilinum S 27.9 Thymus fragantissinus R 36.7 Punica granatin W 66.4 Thymus fragantissinus O 1OOO Rehmannia glittinosa O 83.0 Thymus praecox. Subsp. arcticus O 38.7 Raphantis sativits R 36.5 Thymus pseudoianuginostis R 21.5 Raphantis sativits S 22.4 Thymus vulgaris W 2O.O Reseda luteola S 23.6 Triticosecale spp. O 26.0 Reseda Odorata O 20.3 Trictim aestivum O 20.9 Rheum officinale O 1OOO Triticum turgidium O 49.4 Rheum officinale S 33.3 Triticum spelta O 3S.O Rheum x cuitorum S 34.0 Tropaeofilm maints S 23.5 Ricinits communis S 27.5 Tsiiga diversifolia S 34.3 Ribes Grossiliaria W 24.8 Tsiiga meriensiana S 32.8 Ribes nidigrolaria W 24.4 Typha latifolia S 36.1 Ribes nigrum S SO.1 Urtica dioica O 32.8 Ribes nigrum V 23.8 Vaccinium anglisiifolium S 33.7 Ribes nigrum W 64.1 Vaccinium macrocarpon V 24.1 Ribes Sylvestre W 32.4 Vaccinium macrocarpon W 30.3 Rosa rugosa W 1OOO Vaccinium macrocarpon S 70.9 Rosmarinus officinalis R 75.8 Vaccinium macrocarpon O 57.2 Rosmarinus officinalis W 46.6 Valeriana officinalis O 26.0 Rubus idaeus O 27.6 Valerianeia locusta O 53.7 Rubus idaeus S 24.3 Verbascum thapsus O 22.8 Rubus idaeus O 35.5 Verbascum thapsus S 25.2 Rubus occidentais R 93.2 Veronica officinalis O 29.9 Rubus occidentais O 42.1 iiis S 39.1 Rubus occidentais S 2O.S iiis O 40.O Rumex acetoseiia V 44.9 iiis W 23.5 Rumex crispiis O 31.3 iiis S 26.4 Rumex crispiis R 1OOO Weigela coraeensis S 20.1 Rumex crispiis S 20.8 Weigela hortensis S 25.3 Rita graveolens O 24.1 Xanthium Sibiricum O 28.4 Serenoa repens S 28.5 Zea mayS S 38.4 Salvia officinalis R 66.5 Achillea piarmica A. O S4.3 Salvia officinalis O S4.O Achillea piarmica G O 64.3 Salvia officinalis W 47.2 Geranium praiense R 93.4 Sambucus Canadensis S 23.2 Geranium praiense A. R 98.5 Sambucus Canadensis O 3S.O Geranium praiense G R 97.4 Sambucus Canadensis R 32.6 Thalictrum aquilegiifolium O S3.6 Sambucus Canadensis W S4.O Thalictrum aquilegiifolium G O 60.4 Sanguisorba minor W SO.O Veronica spicata O 55.9 Santolina Chamaecyparissus O 75.8 Veronica spicata A. O 59.2 Santolina Chamaecyparissus R 33.3 Veronica spicata G O 56.2 Satureia montana O 1OOO Helenium spp. O 55.7 Satureia montana R 66.8 Salvia Sylvestris O 77.4 Satureia repandra R 87.4 Salvia Sylvestris A. O 66.9 Schizonepeta tenuifolia O 29.1 Salvia Sylvestris G O 55.0 Schizonepeta tenuifolia S 21.1 Salvia regeliana O 62.6 Scorzorera hispanica R 423 Crambe cordifolia G R 56.3 Scorzorera hispanica S 20.8 Crambe cordifolia G O 56.7 Scutellaria laterifiora S 36.6 Rudbeckia maxima G O 68.4 Serrainia tinctoria S 36.3 Troius Xcuitorum R 97.6 Siim Sisartin O 22.1 Troius Xcuitorum A. R 93.2 Soianum melongena O 22.4 Troius Xcuitorum G R 100.1 Solidago sp S 22.6 Ansonia tabernaemontana A. R 53.2 Sonchi is oleracetis R 4.1.8 Oenotherafitticosa spp. R 109.8 Sorghum cafiorum O 23.0 Oenotherafitticosa spp. O 61.3 Sorghum dochna O 30.3 Oenotherafitticosa spp. A. R 97.5 Sorghum dochna O 53.5 Oenotherafitticosa spp. G R 105.9 Sorghum durra V 21.6 Veronica austriaca Ssp teticrium O 68.6 Sorghum Sudanense V 23.7 Veronica austriaca Ssp teticrium G O S8.1 US 2009/0263516 A1 Oct. 22, 2009 79

TABLE 10-continued TABLE 10-continued

HLE HLE

Nom latin Stress Inhibition Nomlatin Stress Extrait Inhibition Coreopsis verticiliata 55.6 Nicotiana tabacum 60.9 Coreopsis verticiliata 704 Beta vulgaris 71.3 Potentilla fruticosa 104.8 Oenothera biennis 80.3 Potentilla fruticosa 99.4 Aichemia nois 96.O Lysimachia clethroides 67.8 Aichemia nois 87.2 Magnolia x loebneri 61.4 Symphytum officinale 80.2 Iberis sempervirens 624 Fragaria Xananassa 97.9 Iberis sempervirens 63.8 Fragaria Xananassa 93.8 Filipendula vulgaris 98.3 Vaccinium corymbosum 58.6 Filipendula vulgaris 94.5 Vaccinium augustifolium 71.8 Filipendula vulgaris 96.3 Vaccinium augustifolium S3.6 Geranium sanguinelin 89.4 iiis 62.5 Geranium sanguinelin 6.3.3 iiis 79.4 Geranium sanguinelin 82.6 Petasitesiaponicus 56.5 Geranium sanguinelin 53.2 Petasitesiaponicus 53.0 Garanium sanguinelin 88.8 Nicotiana rustica 61.1 Garanium sanguinelin 57.7 Pysalis ixocarpa 53.8 Philadelphus coronarius 55.5 Pteridium aquilinum 69.2 paeonia Stifliticosa S8.9 Pteridium aquilinum 66.2 paeonia Stifliticosa 52.1 Pteridium aquilinum 56.3 Paeonia Stiftuticosa 73.8 Pteridium aquilinum 56.2 Paeonia Stiftuticosa 52.2 Matteuccia pensylvanica 67.2 Paeonia Stiftuticosa 58.7 Matteuccia pensylvanica 59.0 Paeonia Stiftuticosa SO4 Ocimum tenuiflorum 54.8 Dahlia spp. 77.4 Carthamus tinctorius SO.9 Begonia convolvulacea 69.8 Carthamus tinctorius 69.0 Begonia convolvulacea 67.5 Lightstrum vulgare 87.O Begonia convolvulacea 72.6 Lightstrum vulgare 76.2 Begonia emini 72.8 Ligustrum vulgare 85.7 Begonia emini 77.2 Maiva verticiliata 80.1 Begonia emini 75.4 Maiva verticiliata 82.9 Begonia glabra 82.3 Maiva verticiliata 82.4 Begonia mannii 82.5 Hamamelis virginiana e 56.1 Begonia mannii 72.8 Arctostaphylos tiva-lisi 74.8 Begonia polygonoides e 79.0 Arctostaphylos tiva-lisi 86.0 Begonia polygonoides 74.8 Vicia faba G 846 Begonia polygonoides 73.2 Sempervivum tectorum 57.3 Fushia spp. 76.6 Sempervivum tectorum 74.8 Fushia spp. 70.7 Sempervivum tectorum 52.3 Fushia spp. 76.9 Aiiiga reptans 55.3 Button is timbellatus 58.8 Aiiiga reptans 52.3 Onociea sensibilis 54.7 Aiiiga reptans 72.1 Onociea sensibilis SO.1 Phlox paniculata 66.2 Pinus cembra 83.2 Ligularia dentata S2.1 Pinus cembra 76.3 Ligularia dentata SO.8 Corntis sericea 104.O Ligularia dentata S2.6 Corntis sericea 53.4 Achillea ptarmica SO.9 Corntis sericea 91.8 Potentilla fruticosa 98.6 Corntis sericea 51.0 Vernonia gigantea SO.4 Corntis sericea 98.5 Vernonia gigantea 62.3 Hydrangea quiercifolia S8.1 Vernonia gigantea 51.2 Solidago Caesia 60.7 Vernonia gigantea 50.7 Solidago Caesia 6O.S Penstemon digitalis 64.5 Cornus aiba 98.9 Penstemon digitalis 63.5 Cornus aiba 106.7 Penstemon digitalis 57.3 Cornus aiba 85.3 Penstemon digitalis 63.4 Carpinus Caroliniana 95.4 Penstemon digitalis 67.8 Carpinus Caroliniana 86.2 Maius spp. 56.1 Carpinus Caroliniana 94.5 Maius spp. 56.7 Astilbe chinensis S4.3 Maius spp. SO.8 Astilbe chinensis S.O.3 Maius spp. 51.2 SymphoricarpoS albus 52.O Hostasieboidiana SO.9 Euphorbia amygdaloides 103.8 Hamameis mois 99.1 Euphorbia amygdaloides 75.2 Hamameis mois 94.1 Euphorbia amygdaloides 71.3 Hamameis mois 89.4 Viburnum plicatum 61.O Chaenomeles X superba e 56.2 Rubus arcticus 89.3 Chaenomeles X superba 71.9 Rubus arcticus 85.5 Chaenomeles X superba 66.6 Rubus Phoenicolasius 93.2 Chaenomeles X superba S2.O ribes americanum e 704 Centatirea dealbata SO.9 Passifiora spp. 624 Centatirea dealbata 74.1 Rubus occidentais 70.9 Paeonia spp. 79.8 US 2009/0263516 A1 Oct. 22, 2009 80

TABLE 10-continued TABLE 11 HLE Clostripain

Nom latin Stress Extrait Inhibition Inhibition Nomlatin Stress Extrait (%) Paeonia spp. T O 58.6 Paeonia spp. A. R 79.6 Achidinia argitta A. R 34.1 Paeonia spp. A. O 58.5 Anthoxanthum odoratum A. R 3S.O Paeonia spp. G R 82.O Apocyntin cannabintin A. R 47.6 Paeonia spp. G O 6O.O Arctium minus (Hill) Bernhardi A. R 34.5 Lysimachia clethroides R 83.3 Beckmannia erucaeformis A. O 47.3 Lysimachia clethroides O 64.3 Beta vulgaris A. O 37.2 Lysimachia clethroides G R 85.8 Brassica rapa A. O 24.6 Viburnum plicatum G R 57.9 Buddleja davidii A. R 27.6 Buxus microphylla R 58.0 Bupietirlin falcatum A. O 34.6 Astillboides tabularis R 104.2 Capsicum annium A. S 36.8 Astillboides tabularis A. R 108.1 Capsicum annium A. R 24.9 Astillboides tabularis G R 100.3 Coint is cogggria A. R 21.0 Staphylea trifolia A. R 63.6 Koikwitzia annabis A. R 27.9 Bergenia X Schmidtii R 10O.S Laserpitium iaiifolium A. R 20.4 Bergenia X Schmidtii A. R 113.7 Lindera benzoin A. R 38.6 Bergenia X Schmidtii G R 99.3 Lolium perenne A. S 34.7 Rodgersia podophylia R 68.9 Miscanthus saccharifiorus A. O 39.9 Rodgersia podophylia A. R 59.4 Ophiopogoniaponicus A. R 2O.S Rodgersia podophylia G R 56.5 Phaseolus mingo A. S 3O.O Geraniumphaeum R 92.7 Phaseolus Vulgaris A. O 36.4 Geraniumphaeum A. R 84.3 Phaseolus Vulgaris A. R 23.4 Geraniumphaeum G R 101.0 Plumbago zeylanica A. O 26.5 Rubits pubescens R 71.5 Portuiacea oierracea A. O 22.2 Rubits pubescens A. R 76.2 Salix purpurea F. Gracilis A. R 38.6 Rubits pubescens G R 82.8 Soianum melanocerastin A. S 26.0 Taxus X media R 60.1 Stellaria media (linné) Cyrillo A. O 31.6 Taxus X media A. R 61.6 Tanacetum vulgare A. S 35.3 Taxus X media G R 52.3 Tanacetum vulgare A. O 35.4 Geranium X cantabrigiense R 106.1 Trifolium incarnatum A. S 22.0 Geranium X cantabrigiense A. R 94.2 Vaccini in augustifolium A. O 34.0 Geranium X cantabrigiense G R 95.9 Zea Mays A. O 21.9 Fuchia magellanica R 10O2 Afiamomum meiegueta G O 27.9 Fuchia magellanica A. R 91.9 Aium sativum G O 35.3 Fuchia magellanica G R 102.2 Anthemis nobiis G O 35.8 Microbiata decussaia A. R 51.5 Anthlirium guildingii G O 55.2 Microbiata decussaia G R 51.9 Astilbex arendsii G R 25.6 Rhododendron spp. G R 51.2 Beta vulgaris G R 28.0 Stephanandra incisa T R 102.5 Campaniiia raptinctius G S 24.5 Stephanandra incisa A. R 104.6 Cirsium arvense G R 3O.O Stephanandra incisa G R 99.1 Cissus discolor G O 40.8 Corylus maxima A. R SO.8 Coccoloba Caracasana G R 24.9 Corylus maxima G R 57.1 Convailaria maialis G R 28.5 Cypertis alternifolius G R 56.2 Cucurbitapepo G O 20.9 Soleiroia Soleiroii A. R 51.2 Cucurbitapepo G S 42.5 Soleiroia Soleiroii G R 68.0 Errhenaiherum eiatius G S 21.6 Streitzia reginae T R 106.5 Filipendula rubra G R 44.3 Streitzia reginae A. R 94.3 Gaium odoratum G O 31.2 Streitzia reginae G R 111.7 Glycyrrhiza glabra G O 27.6 Hedychium coronarium T R 53.5 Hedychium sp. G O 35.6 Hedychium coronarium A. R 86.9 Houttuynia Cordata G O 30.2 Hedychium coronarium G R 74.6 Lactica Saiiva G O 28.8 Streitzia reginae T R 78.6 Lactica Saiiva G O 21.6 Streitzia reginae A. R 78.0 Lotus tetragonolobits G S 42.9 Streitzia reginae G R 107.3 Lycopersicon escientiin G R 32.3 SymphoricarpoS orbiculatus G R 58.7 Lysimachia clethroides G R 22.7 Rodgersia spp. A. R 59.5 Magnolia Stellata G R 23.6 Rodgersia spp. G R 59.0 Microlepia pial-phylia G O 21.0 Lamiastrum galeobdolon T R 91.5 Miscanthus saccharifiorus G R 25.6 Astilbex arendsii A. R 84.5 Myrica pensylvanica G O 22.7 Cienais alpina A. R 544 N G O 24.4 Stewartia pseudocamelia T R 75.5 Nicotiana tabacum G R 22.8 Paeonia G R 31.3 Stewartia pseudocamelia A. R 84.1 Pastinaca Saiiva G R 29.2 Stewartia pseudocamelia G R 813 pastinaca Saiiva G S 44.7 Pinus mugo T R S8.9 Phaseolus vulgaris G O 36.7 Pinus mugo A. R 53.7 Pteridium aquilinum G O 22.2 Pinus mugo G R 61.7 Solidago sp? G S 40.8 Rubus thibetanus T R 97.6 Symphytum officinale G S 22.7 Rubus thibetanus A. R 97.9 Tanacetum vulgare G S 31.4 Rubus thibetanus G R 95.4 Thymus fragantissuinus G O 20.1 Urtica dioica G O 32.6 US 2009/0263516 A1 Oct. 22, 2009 81

TABLE 11-continued TABLE 12-continued

Clostripain Subtilisin Inhibition Nom latin Stress Extrait (%) Nom latin Stress Extrait Inhibition (%) 22.4 Zea mays 24.9 Abies baisanea 38.6 Typha latifolia L. Allium ampeioprastin 30.3 Zea mays 20.9 Aium sativum 55.5 Zea Mays 34.7 Amaranthus gangeticits 75.4 Adiantum pedatum 22.4 Apium graveolens 21.7 Aralia Cordata 48.2 Cichorium endivia 26.7 Asclepias tuberosa 2O2 Cucurbitapepo 20.8 Asciinidia chinensis 47.7 Echinacea purpurea 27.6 Baptisia tinctoria SO.4 Betula alleghaniensis 24.9 Lactica Saiiva 36.4 Brassica oleracea 21.4 pastinaca sativa 52.1 Brassica rapa 3O.S Pastinaca Saiiva 20.1 Caladium sp. 39.8 Carica papaya 23.8 Ribes nigrum 41.2 Chaerophyllum bulbosum 24.3 Symphytum officinale 3O.O Chrysanthemum coronarium 32.7 Urtica dioica 38.2 Clematischiisanensis 21.6 22.3 Coccoloba Caracasana 40.1 Vitis sp. Cocos nucifera 22.5 Aichemia nois 22.6 Cornits maS 34.2 Aithacea officinalis 33.5 Cucurbitapepo 24.9 53.5 Cymbopogon citratus 20.4 Althaea officinalis Forsythia X intermedia 44.0 Aralia Cordata 21.0 Heliotropium arborescens 27.1 Asciinidia chinensis 38.6 Lonicera ranosissina 34.9 Astillboides tabularis 41.O Maius pranifolia 23.6 Marrubium vulgare 49.3 Averrhoa caramboia 20.9 Miscanthus sinensis Anchess 26.9 Baptisia tinctoria 25.5 Nephelium longana ou Euphoria longana 42.6 Beta vulgaris 24.2 Psoralea conviifolia 54.0 Raphantis sativits 21.4 Convailaria maialis 48.2 Ribes Nigrum 40.9 Daitira Stranonium 27.3 Rubus thibetanus 24.2 Dioscorea batatas 36.4 Rumex acetosella linné 35.2 Eleusine coracana 26.2 Sechium edule 25.6 Stachys macrantha 25.9 Fragaria Xananassa 39.5 Teparty 34.9 Ginkgo biloba 98.8 Thymus vulgaris "Argenteus." 25.3 Heliotropium arborescens 35.2 Trifolium pratense 31.3 Hibiscus cannabinus 25.2 Troius Xcuitorum 26.5 Uvularia perfoliata 38.3 Hyperictim perforatin 30.3 Vaccinum macrocarpon 39.2 Ipomea bataias 22.1 Verbena officinalis 46.2 Lathyrus Sylvestris 21.8 Zea mays 32.5 Lonicera ranosissina 29.6 Lonicera ranosissina 39.9 Lonicera syringantha 31.1 TABLE 12 Madia Saiiva 27.5 Monarda 28.2 Subtilisin Ocimum Basilicum 27.2 Nom latin Stress Extrait Inhibition (%) Peucedanum of easeinum 29.2 Psoralea conviifolia 20.9 Actaea racemosa 20.6 Aichemia motiis 23.5 Rahmni is fianguia 26.4 Borago officinalis 2O.S Raphantis sativits 25.5 Capsicum annittin 24.7 Rheum rhabarbarium 21.6 Cornus Canadensis L. 22.6 28.9 Genista multibracteata 21.3 Ribes Nigrum Glycine max 26.0 Rubus occidentais 22.8 Lolium perenne 75.9 Rimes Scittatus 21.4 Matricaria recitita 23.2 Solidago Hybrida 34.5 Phaseolus Vulgaris 34.7 Printis Tomeiniosa 20.4 Tanacetum baisania 33.9 Scuttellaria laterifiora 33.5 Vaccinum macrocarpon 81.2 Solidago Canadensis 42.O Xanthium Sibiricum 31.7 Spinacia oleracea 1OO.O Tanacetum vulgare 42.4 Zea mays 28.3 Tanacetum vulgare 26.7 US 2009/0263516 A1 Oct. 22, 2009 82

TABLE 13(con) Endothelial Cell Migration Cellular Migration Assay Cord Formation Assay % inhibition % inhibition

Plant Stress Part of Plant? 2.5x 1.25x O.62x O.31x 2.5x 1.25x 0.62x 0.31x

Amaranthus candathus G 100 72 1OO 81 1OO 100 100 100 Ambrosia artemisiifolia N FI 99 91 61 57 100 90 4 O Aronia Xprunifolia N St 93 75 93 50 26 2O 19 Brassica naptis N 51 33 O O 77 59 43 41 Brassica oleracea N 35 15 O 4 50 29 30 2O Brassica oleracea A. 49 28 27 6 65 32 15 21 Bronts inermis A. 21 14 O 93 90 44 36 17 Chenopodium quinoa N LiSt Se 90 85 53 42 1OO 100 44 26 Citritius ianatus A. 21 17 6 O 88 35 23 14 Cynara cardiinctiitis G Fr 36 O 36 O 4 O O 10 Subsp. Cardiinctius Doichosiabiah G FI Fr O O O O 60 64 68 83 Foeniculum vulgare N 69 21 23 11 64 47 62 61 Hypomyces N Fr 77 67 2O 11 85 59 31 5 lactiftuorum Lotus corniculatus A. LFrf St 9 O O O 93 83 77 57 Lotus corniculatus N Se O O O O 58 11 26 O Manihot escuienia N Fr 39 O O O 33 30 25 26 Matricaria recitita G LFIFSt 34 31 4 O 74 6 1 2O Meilotus aibus G St O 70 15 O O Phaseolus vulgaris A. 51 17 4 7 S4 29 10 18 Phaseolus vulgaris G 33 13 25 18 82 56 51 41 Pistin Saivain N St 16 24 4 O 38 16 13 O Raphanus raphanistrum G 46 24 10 O 88 46 23 23 Ribes Sylvestre N 96 87 S6 26 59 49 69 56 Rumex crispiis A. R 96 83 O 18 96 46 17 13 Rumex crispiis G R 36 O 36 O 80 100 86 36 Rumex Scittatus N 70 6 O O 100 2O O O Tanaceilin G 1OO 99 56 O 1OO 100 42 18 cinerariifolium Tropaeoluim maints G 7 O O O 65 29 18 4 Tsuga Canadensis N LFrf St 8O 82 64 68 41 31 31 Tsiiga diversifolia N St 57 8 O O 99 43 18 27 Vaccinium N Fr 59 15 6 O 62 7 11 24 angustifolium Zea mays N 11 O O 11 66 24 14 6 Zingiber officinale N Fr O O O O 59 38 27 30 'N: no stress; A: stress A: G: stress G. °EP: Entire plant: Fl: Flower; Fr. Fruit: L: Leaf R: Root; Se: Seed: St: Stem

TABLE 14(con) TABLE 14(con)-continued Migration of Cancer Cells Migration of Cancer Cells Part of % inhibition Part of % inhibition

254Plant Stress' plant 2.5x 1.25x 0.62x 0.31x 254Plant Stress plant 2.5x 1.25x O.62x 0.31x

Aium tuberosum G Frf Fl 68 O O O Daiiciis Caroia G O 30 O 38 Aium tuberosum A. Frf Fl 73 76 8O 36 Doichosiabiah G 81 86 92 77 Aithacea officinalis N St 66 O O O Foeniculum vulgare N 6 6 5 O Amaranthus candathus G 1OO 100 100 98 Hypomyces N 66 72 O O Ambrosia N FI 92 76 O O lactiftuorum artemisiifolia Iberis sempervirens A. 1OO 42 4 O Angelica Sinensis N EP 1OO 75 32 53 Iberis sempervirens G 1OO 100 98 91 Aronia Xprunifolia N St 95 94 95 97 Lotus corniculatus A. 88 51 35 21 Asartin europaeum G 67 49 O 73 Lotus corniculatus N 47 71 8O 55 Begonia Hannii A. LFIFFrf St 1OO 100 14 O Linaria annia N 1OO 100 68 9 Begonia polygonoides A LFIFSt 1OO O O O Meilotus aibus G S4 O O O Brassica oleracea N 78 45 49 57 Phaseolus vulgaris G 43 2 O O Bronts inermis A. 91 91 93 90 Physostegia virginiana G 78 O O O Chenopodium quinoa N LiSt Se 1OO 99 58 31 Pistin Saivain N 27 23 12 9 Conyza Canadensis G E 65 8 O O Rheum rhabarbarium A 90 90 87 87 Cynara cardiinctiitis G Fr 99 39 33 48 Ribes Sylvestre N 91 87 17 O Subsp. Cardiinctius Rubus occidenia is N 84 82 89 90 US 2009/0263516 A1 Oct. 22, 2009

6. The formulation according to claim 5, wherein said TABLE 14(con)-continued chemical stress comprises treatment with gamma linolenic acid or arachidonic acid. Migration of Cancer Cells 7. The formulation according to claim 1, wherein each of Part of % inhibition said one or more plant extracts is selected from: 254Plant Stress' plant 2.5x 1.25x 0.62x 0.31x an extract derived from fruits, flowers, or a combination thereof of Allium tuberosum, Rumex crispiis A. R 96 89 8 O Rumex crispiis G R 99 86 O O an extract derived from leaves, stems, or a combination Rumex Scittatus N 1OO 88 O O thereof of Althacea officinalis, Salvia officinalis N St 59 O O O an extract derived from leaves of Amaranthus candathus, Salvia officinalis A. St 98 89 39 Solidago Canadensis G 1OO 100 93 93 an extract derived from flowers of Ambrosia artemesiifolia, Solidago sp. A. LFIFSt 1OO 83 O O an extract derived from entire Angelica sinensis plants, Solidago X hybrida N St 1OO 96 70 7 an extract derived from leaves, stems, or a combination Solidago X hybrida A. St 1OO 90 O O thereof of Aroniaxprunifolia, Solidago X hybrida N FI 1OO 51 13 O Solidago X hybrida A. FI 1OO 99 91 89 an extract derived from leaves of Asarum europaeum, Tanaceilin G 1OO 100 99 65 an extract derived from leaves, flowers, fruits, stems, or a cinerariifolium combination thereof of Begonia hannii, Taraxacum officinale N 1OO 71 47 O an extract derived from leaves, flowers, stems, or a combi Tsuga Canadensis N LFrf St 65 64 63 O nation thereof of Begonia polygonoides, Tsiiga diversifolia N St 1OO 63 38 90 Zea mays N 36 35 25 24 an extract derived from leaves of Brassica napus, Zingiber officinale N Fr 90 56 13 O an extract derived from leaves of Brassica oleracea, an extract derived from leaves of Bromus inermis, 'N: no stress; A: stress A: G: stress G. an extract derived from leaves, stems, seeds, or a combi EP: Entire plant: Fl: Flower; Fr. Fruit: L: Leaf R: Root; Se: Seed: St: Stem nation thereof of Chenopodium quinoa, an extract derived from leaves of Citrullus lanatus, I claim: an extract derived from entire Conyza Canadensis plants, 1. A formulation comprising a physiologically acceptable an extract derived from fruits of Cynara Cardunculus diluent, excipient or carrier, and one or more plant extracts Subsp. Cardunculus, that inhibit the activity of at least one extracellular protease selected from the group of matrix metalloprotease-1 (MMP an extract derived from leaves of Daucus carota, 1), matrix metalloprotease-2 (MMP-2), matrix metallopro an extract derived from flowers, fruits, or a combination tease-3 (MMP-3), matrix metalloprotease-9 (MMP-9), and thereof of Dolichos lablab, cathepsin B, each plant extract having at least one of the an extract derived from leaves of Foeniculum vulgare, following properties: an extract derived from fruits of Hypomyces lactifluorum, (i) inhibits migration of endothelial cells, an extract derived from leaves, stems, or a combination (ii) inhibits migration of neoplastic cells, thereof of Iberis sempervirens, and each of said one or more plant extracts derived from an extract derived from leaves, fruits, stems, seeds, or a Allium tuberosum, Althacea officinalis, Amaranthus combination thereof of Lotus corniculatus, candathus, Ambrosia artemesiifolia, Angelica Sinensis, an extract derived from fruits of Lunaria annua, Aroniaxprunifolia, Asarum europaeum, Begonia han an extract derived from fruits of Manihot esculenta, nii, Begonia polygonoides, Brassica napus, Brassica an extract derived from leaves, flowers, stems, or a combi oleracea, Bromus inermis, Chenopodium quinoa, Cit nation thereof of Matricaria recutita, rullus lanatus, Conyza Canadensis, Cynara Cardunculus an extract derived from leaves, stems, or a combination Subsp. Cardunculus, Daucus carota, Dolichos lablab, thereof of Melilotus albus, Foeniculum vulgare, Hypomyces lactifluorum, Iberis an extract derived from leaves of Phaseolus vulgaris, sempervirens, Lotus corniculatus, Lunaria annua, an extract derived from leaves, stems, or a combination Manihot esculenta, Matricaria recutita, Melilotus thereof of Physostegia virginiana, albus, Phaseolus vulgaris, Physostegia virginiana, an extract derived from leaves, stems, or a combination Pisum sativum, Raphanus raphanistrum, Rheum rha thereof of Pisum sativum, barbarum, Ribes Sylvestre, Rubus occidentalis, Rumex an extract derived from leaves of Raphanus raphanistrum, crispus, Rumex scutatus, Salvia officinalis, Solidago an extract derived from leaves of Rheum rhabarbarum, Canadensis, Solidago spp., Solidagoxhybrida, Tanace an extract derived from leaves of Ribes Sylvestre, tum cinerariifolium, Taraxacum officinale, Tropaeolum an extract derived from fruits of Rubus Occidentalis, majus, Tsuga Canadensis, Tsuga diversifolia, Vaccinium an extract derived from roots of Rumex crispus, angustifolium, Zea mays or Zingiber officinale. an extract derived from leaves of Rumex scutatus, 2. The formulation according to claim 1, wherein said an extract derived from leaves, stems, or a combination formulation inhibits angiogenesis. thereof of Salvia officinalis, 3. The formulation according to claim 1, wherein said an extract derived from flowers of Solidago Canadensis, formulation inhibits prevents metastasis of cancer cells. an extract derived from leaves, flowers, stems, or a combi 4. The formulation according to claim 1, wherein at least nation thereof of Solidago spp., one of said one or more plant extracts is derived from a plant an extract derived from leaves, flowers, stems, or a combi that has been Subjected to one or more stress prior to harvest. nation thereof of Solidagoxhybrida, 5. The formulation according to claim 4, wherein said one an extract derived from leaves of Tanacetum cinerariifo or more stress is a chemical stress. lium, US 2009/0263516 A1 Oct. 22, 2009 84

an extract derived from leaves of Taraxacum officinale, an extract derived from leaves, stems, or a combination an extract derived from leaves of Tropaeolum majus, thereof of Iberis sempervirens, an extract derived from leaves, fruits, stems, or a combina an extract derived from leaves, fruits, stems, seeds or a tion thereof of Tsuga Canadensis, combination thereof of Lotus corniculatus, an extract derived from leaves, stems, or a combination an extract derived from fruits of Lunaria annua, thereof of Tsuga diversifolia, an extract derived from fruits of Manihot esculenta, an extract derived from fruits of Vaccinium angustifolium, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves of Zea mays, and nation thereof of Matricaria recutita, an extract derived from fruits of Zingiber officinale. an extract derived from leaves, stems, or a combination 8. The formulation according to claim 1, wherein each of thereof of Melilotus albus, said one or more plant extracts is prepared by extraction of an extract derived from leaves of Phaseolus vulgaris, plant material with an alcoholic solvent, an aqueous solvent, an extract derived from leaves, stems, or a combination or a combination thereof. thereof of Physostegia virginiana, 9. The formulation according to claim 1, wherein said an extract derived from leaves, stems, or a combination formulation is formulated for oral administration. thereof of Pisum sativum, 10. The formulation according to claim 1, wherein said an extract derived from leaves of Raphanus raphanistrum, formulation is formulated for topical administration. an extract derived from leaves of Rheum rhabarbarum, 11. The formulation according to claim 9, wherein said an extract derived from leaves of Ribes Sylvestre, formulation is a nutraceutical formulation. an extract derived from fruits of Rubus Occidentalis, 12. The formulation according to claim 1, wherein said an extract derived from roots of Rumex crispus, formulation is a pharmaceutical composition and said physi an extract derived from leaves of Rumex scutatus, ologically acceptable diluent, excipient or carrier is a phar an extract derived from leaves, stems, or a combination maceutically acceptable diluent, excipient or carrier. thereof of Salvia officinalis, 13. A method of inhibiting abnormal cell migration com an extract derived from flowers of Solidago Canadensis, prising contacting neoplastic or endothelial cells with an an extract derived from leaves, flowers, stems, or a combi effective amount of the formulation according to claim 1. nation thereof of Solidago spp., 14. The method according to claim 13, wherein at least one an extract derived from leaves, flowers, stems, or a combi of said one or more plant extracts is derived from a plant that nation thereof of Solidagoxhybrida, has been Subjected to one or more stress prior to harvest. an extract derived from leaves of Tanacetum cinerariifo 15. The method according to claim 14, wherein said one or lium, more stress is a chemical stress. an extract derived from leaves of Taraxacum officinale, 16. The method according to claim 15, wherein said chemi an extract derived from leaves of Tropaeolum majus, cal stress comprises treatment with gamma linolenic acid or an extract derived from leaves, fruits, stems, or a combina arachidonic acid. tion thereof of Tsuga Canadensis, 17. The method according to claim 13, wherein each of said an extract derived from leaves, stems, or a combination one or more plant extracts is selected from: thereof of Tsuga diversifolia, an extract derived from fruits, flowers, or a combination an extract derived from fruits of Vaccinium angustifolium, thereof of Allium tuberosum, an extract derived from leaves of Zea mays, and an extract derived from leaves, stems, or a combination an extract derived from fruits of Zingiber officinale. thereof of Althacea officinalis, 18. The method according to claim 13, wherein each of said an extract derived from leaves of Amaranthus candathus, one or more plant extracts is prepared by extraction of plant an extract derived from flowers of Ambrosia artemesiifolia, material with an alcoholic solvent, an aqueous solvent, or a an extract derived from entire Angelica sinensis plants, combination thereof. an extract derived from leaves, stems, or a combination 19. The method according to claim 13, wherein said thereof of Aroniaxprunifolia, method is an in vivo method. an extract derived from leaves of Asarum europaeum, 20. A method of inhibiting angiogenesis in a Subject com an extract derived from leaves, flowers, fruits, stems, or a prising administering to said Subject an effective amount of combination thereof of Begonia hannii, the formulation according to claim 1, wherein said formula an extract derived from leaves, flowers, stems, or a combi tion inhibits migration of endothelial cells. nation thereof of Begonia polygonoides, 21. The method according to claim 20, wherein at least one an extract derived from leaves of Brassica napus, of said one or more plant extracts is derived from a plant that an extract derived from leaves of Brassica oleracea, have been subjected to one or more stress prior to harvest. an extract derived from leaves of Bromus inermis, 22. The method according to claim 21, wherein said one or an extract derived from leaves, stems, seeds, or a combi more stress is a chemical stress. nation thereof of Chenopodium quinoa, 23. The method according to claim 22, wherein said chemi an extract derived from leaves of Citrullus lanatus, cal stress comprises treatment with gammalinolenic acid or an extract derived from entire Conyza Canadensis plants, arachidonic acid. an extract derived from fruits of Cynara Cardunculus 24. The method according to claim 20, wherein each of said Subsp. Cardunculus, one or more plant extracts is selected from: an extract derived from leaves of Daucus carota, an extract derived from fruits, flowers, or a combination an extract derived from flowers, fruits, or a combination thereof of Allium tuberosum, thereof of Dolichos lablab, an extract derived from leaves, stems, or a combination an extract derived from leaves of Foeniculum vulgare, thereof of Althacea officinalis, an extract derived from fruits of Hypomyces lactifluorum, an extract derived from leaves of Amaranthus candathus, US 2009/0263516 A1 Oct. 22, 2009 85

an extract derived from flowers of Ambrosia artemesiifolia, 25. The method according to claim 20, wherein each of said an extract derived from entire Angelica sinensis plants, one or more plant extracts is prepared by extraction of plant an extract derived from leaves, stems, or a combination material with an alcoholic solvent, an aqueous solvent, or a thereof of Aroniaxprunifolia, combination thereof. an extract derived from leaves of Asarum europaeum, 26. The method according to claim 20, wherein each of said an extract derived from leaves, flowers, fruits, stems, or a one or more plant extracts is derived from Amaranthus can combination thereof of Begonia hannii, dathus, Ambrosia artemesiifolia, Aronia xprunifolia, Bras an extract derived from leaves, flowers, stems, or a combi sica napus, Brassica oleracea, Bromus inermis, Chenopo nation thereof of Begonia polygonoides, dium quinoa, Citrullus lanatus, Dolichos lablab, Foeniculum an extract derived from leaves of Brassica napus, vulgare, Hypomyces lactifluorum, Lotus corniculatus, Mani hot esculenta, Matricaria recutita, Melilotus albus, Phaseo an extract derived from leaves of Brassica oleracea, lus vulgaris, Pisum sativum, Raphanus raphanistrum, Ribes an extract derived from leaves of Bromus inermis, Sylvestre, Rumex Crispus, Rumex scutatus, Tanacetum ciner an extract derived from leaves, stems, seeds, or a combi ariifolium, Tropaeolum majus, Tsuga Canadensis, Tsuga nation thereof of Chenopodium quinoa, diversifolia, Vaccinium angustifolium, Zea mays or Zingiber an extract derived from leaves of Citrullus lanatus, officinale. an extract derived from entire Conyza Canadensis plants, 27. The method according to claim 26, wherein each of said an extract derived from fruits of Cynara Cardunculus one or more plant extracts is selected from: Subsp. Cardunculus, an extract derived from leaves of Amaranthus candathus, an extract derived from leaves of Daucus carota, an extract derived from flowers of Ambrosia artemesiifolia, an extract derived from flowers, fruits, or a combination an extract derived from leaves, stems, or a combination thereof of Dolichos lablab, thereof of Aroniaxprunifolia, an extract derived from leaves of Foeniculum vulgare, an extract derived from leaves of Brassica napus, an extract derived from fruits of Hypomyces lactifluorum, an extract derived from leaves of Brassica oleracea, an extract derived from leaves, stems, or a combination an extract derived from leaves of Bromus inermis, thereof of Iberis sempervirens, an extract derived from leaves, stems, seeds, or a combi an extract derived from leaves, fruits, stems, seeds, or a nation thereof of Chenopodium quinoa, combination thereof of Lotus corniculatus, an extract derived from leaves of Citrullus lanatus, an extract derived from fruits of Lunaria annua, an extract derived from flowers, fruits, or a combination an extract derived from fruits of Manihot esculenta, thereof of Dolichos lablab, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves of Foeniculum vulgare, nation thereof of Matricaria recutita, an extract derived from fruits of Hypomyces lactifluorum, an extract derived from leaves, stems, or a combination an extract derived from leaves, fruits, stems, seeds, or a thereof of Melilotus albus, combination thereof of Lotus corniculatus, an extract derived from leaves of Phaseolus vulgaris, an extract derived from fruits of Manihot esculenta, an extract derived from leaves, stems, or a combination an extract derived from leaves, flowers, stems, or a combi thereof of Physostegia virginiana, nation thereof of Matricaria recutita, an extract derived from leaves, stems, or a combination an extract derived from leaves, stems, or a combination thereof of Pisum sativum, thereof of Melilotus albus, an extract derived from leaves of Raphanus raphanistrum, an extract derived from leaves of Phaseolus vulgaris, an extract derived from leaves of Rheum rhabarbarum, an extract derived from leaves, stems, or a combination thereof of Pisum sativum, an extract derived from leaves of Ribes Sylvestre, an extract derived from leaves of Raphanus raphanistrum, an extract derived from fruits of Rubus Occidentalis, an extract derived from leaves of Ribes Sylvestre, an extract derived from roots of Rumex crispus, an extract derived from roots of Rumex crispus, an extract derived from leaves of Rumex scutatus, an extract derived from leaves of Rumex scutatus, an extract derived from leaves, stems, or a combination an extract derived from leaves of Tanacetum cinerariifo thereof of Salvia officinalis, lium, an extract derived from flowers of Solidago Canadensis, an extract derived from leaves of Tropaeolum majus, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves, fruits, stems, or a combina nation thereof of Solidago spp., tion thereof of Tsuga Canadensis, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves, stems, or a combination nation thereof of Solidagoxhybrida, thereof of Tsuga diversifolia, an extract derived from leaves of Tanacetum cinerariifo an extract derived from fruits of Vaccinium angustifolium, lium, an extract derived from leaves of Zea mays, and an extract derived from leaves of Taraxacum officinale, an extract derived from fruits of Zingiber officinale. an extract derived from leaves of Tropaeolum majus, 28. The method according to claim 20, wherein said for an extract derived from leaves, fruits, stems, or a combina mulation is administered orally to said Subject. tion thereof of Tsuga Canadensis, 29. The method according to claim 20, wherein said for an extract derived from leaves, stems, or a combination mulation is administered topically to said Subject. thereof of Tsuga diversifolia, 30. A method of inhibiting metastasis of cancer cells in a an extract derived from fruits of Vaccinium angustifolium, Subject comprising administering to said Subject an effective an extract derived from leaves of Zea mays, and amount of the formulation according to claim 1, wherein said an extract derived from fruits of Zingiber officinale. formulation inhibits migration of neoplastic cells. US 2009/0263516 A1 Oct. 22, 2009

31. The method according to claim30, wherein at least one an extract derived from leaves, flowers, stems, or a combi of said one or more plant extracts is derived from a plant that nation thereof of Solidagoxhybrida, has been Subjected to one or more stress prior to harvest. an extract derived from leaves of Tanacetum cinerariifo 32. The method according to claim 31, wherein said one or lium, more stress is a chemical stress. an extract derived from leaves of Taraxacum officinale, 33. The method according to claim 32, wherein said chemi an extract derived from leaves of Tropaeolum majus, cal stress comprises treatment with gamma linolenic acid or an extract derived from leaves, fruits, stems, or a combina arachidonic acid. tion thereof of Tsuga Canadensis, 34. The method according to claim30, wherein each of said an extract derived from leaves, stems, or a combination one or more plant extracts is selected from: thereof of Tsuga diversifolia, an extract derived from fruits, flowers, or a combination an extract derived from fruits of Vaccinium angustifolium, thereof of Allium tuberosum, an extract derived from leaves of Zea mays, and an extract derived from leaves, stems, or a combination an extract derived from fruits of Zingiber officinale. thereof of Althacea officinalis, 35. The method according to claim 30, wherein each of said an extract derived from leaves of Amaranthus candathus, one or more plant extracts is prepared by extraction of plant an extract derived from flowers of Ambrosia artemesiifolia, material with an alcoholic solvent, an aqueous solvent, or a an extract derived from entire Angelica sinensis plants, combination thereof. an extract derived from leaves, stems, or a combination 36. The method according to claim 30, wherein each of said thereof of Aroniaxprunifolia, one or more plant extracts is derived from Allium tuberosum, an extract derived from leaves of Asarum europaeum, Althacea officinalis, Amaranthus candathus, Ambrosia arte an extract derived from leaves, flowers, fruits, stems, or a mesiifolia, Angelica sinensis, Aroniaxprunifolia, Asarum combination thereof of Begonia hannii, europaeum, Begonia hannii, Begonia polygonoides, Brassica an extract derived from leaves, flowers, stems, or a combi napa, Brassica oleracea, Bromus inermis, Chenopodium nation thereof of Begonia polygonoides, quinoa, Citrullus lanatus, Conyza Canadensis, Cynara car an extract derived from leaves of Brassica napus, dunculus, Dolichos lablab, Hypomyces lactifluorum, Iberis an extract derived from leaves of Brassica oleracea, sempervirens, Lotus corniculatus, Lunaria annua, Manihot an extract derived from leaves of Bromus inermis, esculenta, Matricaria recutita, Melilotus albus, Phaseolus an extract derived from leaves, stems, seeds, or a combi vulgaris, Physostegia virginiana, Pisum sativum, Raphanus nation thereof of Chenopodium quinoa, raphanistrum, Rheum rabarbarum, Ribes Sylvestre, Rubus an extract derived from leaves of Citrullus lanatus, occidentalis, Rumex Crispus, Rumex scutatus, Salvia offici an extract derived from entire Conyza Canadensis plants, nalis, Solidago Canadensis, Solidago spp., Solidagoxhy an extract derived from fruits of Cynara Cardunculus brida, Tanacetum cinerariifolium, Taraxacum officinale, Tro Subsp. Cardunculus, paeolum majus, Tsuga Canadensis, Tsuga diversifolia, an extract derived from leaves of Daucus carota, Vaccinium angustifolium, Zea mays or Zingiber officinale. an extract derived from flowers, fruits, or a combination 37. The method according to claim 36, wherein each of said thereof of Dolichos lablab, one or more plant extracts is selected from: an extract derived from leaves of Foeniculum vulgare, an extract derived from fruits, flowers, or a combination an extract derived from fruits of Hypomyces lactifluorum, thereof of Allium tuberosum, an extract derived from leaves, stems, or a combination an extract derived from leaves, stems, or a combination thereof of Iberis sempervirens, thereof of Althacea officinalis, an extract derived from leaves, fruits, stems, seeds, or a an extract derived from leaves of Amaranthus candathus, combination thereof of Lotus corniculatus, an extract derived from flowers of Ambrosia artemesiifolia, an extract derived from fruits of Lunaria annua, an extract derived from entire Angelica sinensis plants, an extract derived from fruits of Manihot esculenta, an extract derived from leaves, stems, or a combination an extract derived from leaves, flowers, stems, or a combi thereof of Aroniaxprunifolia, nation thereof of Matricaria recutita, an extract derived from leaves of Asarum europaeum, an extract derived from leaves, stems, or a combination an extract derived from leaves, flowers, fruits, stems, or a thereof of Melilotus albus, combination thereof of Begonia hannii, an extract derived from leaves of Phaseolus vulgaris, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves, stems, or a combination nation thereof of Begonia polygonoides, thereof of Physostegia virginiana, an extract derived from leaves of Brassica napus, an extract derived from leaves, stems, or a combination an extract derived from leaves of Brassica oleracea, thereof of Pisum sativum, an extract derived from leaves of Bromus inermis, an extract derived from leaves of Raphanus raphanistrum, an extract derived from leaves, stems, seeds, or a combi an extract derived from leaves of Rheum rhabarbarum, nation thereof of Chenopodium quinoa, an extract derived from leaves of Ribes Sylvestre, an extract derived from leaves of Citrullus lanatus, an extract derived from fruits of Rubus Occidentalis, an extract derived from entire Conyza Canadensis plants, an extract derived from roots of Rumex crispus, an extract derived from fruits of Cynara Cardunculus an extract derived from leaves of Rumex scutatus, Subsp. Cardunculus, an extract derived from leaves, stems, or a combination an extract derived from flowers, fruits, or a combination thereof of Salvia officinalis, thereof of Dolichos lablab, an extract derived from flowers of Solidago Canadensis, an extract derived from fruits of Hypomyces lactifluorum, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves, stems, or a combination nation thereof of Solidago spp., thereof of Iberis sempervirens, US 2009/0263516 A1 Oct. 22, 2009 87

an extract derived from leaves, fruits, stems, seeds, or a an extract derived from flowers of Solidago Canadensis, combination thereof of Lotus corniculatus, an extract derived from leaves, flowers, stems, or a combi an extract derived from fruits of Lunaria annua, nation thereof of Solidago spp., an extract derived from fruits of Manihot esculenta, an extract derived from leaves, flowers, stems, or a combi an extract derived from leaves, flowers, stems, or a combi nation thereof of Solidagoxhybrida, nation thereof of Matricaria recutita, an extract derived from leaves of Tanacetum cinerariifo an extract derived from leaves, stems, or a combination lium, an extract derived from leaves of Taraxacum officinale, thereof of Melilotus albus, an extract derived from leaves of Tropaeolum majus, an extract derived from leaves of Phaseolus vulgaris, an extract derived from leaves, fruits, stems, or a combina an extract derived from leaves, stems, or a combination tion thereof of Tsuga Canadensis, thereof of Physostegia virginiana, an extract derived from leaves, stems, or a combination an extract derived from leaves, stems, or a combination thereof of Tsuga diversifolia, thereof of Pisum sativum, an extract derived from fruits of Vaccinium angustifolium, an extract derived from leaves of Raphanus raphanistrum, an extract derived from leaves of Zea mays, and an extract derived from leaves of Rheum rhabarbarum, an extract derived from fruits of Zingiber officinale. an extract derived from leaves of Ribes Sylvestre, 38. The method according to claim 30, wherein said for an extract derived from fruits of Rubus Occidentalis, mulation is administered orally to said Subject. an extract derived from a root of Rumex Crispus, 39. The method according to claim 30, wherein said for an extract derived from leaves of Rumex scutatus, mulation is administered topically to said Subject. an extract derived from leaves, stems, or a combination thereof of Salvia officinalis, c c c c c