Biographical Sketch

Denis Duboule

Head, Laboratory of Developmental Genomics (UPDUB) Federal Institute of Technology (EPFL), Lausanne

Denis Duboule is born in 1955 and is both swiss and french national. He studied biology at the University of , where he obtained a PhD in mammalian embryology in 1984. He then spent 10 years abroad, first as a group leader in the medical faculty in Strasbourg (France), then at the European Laboratory for Molecular Biology (EMBL) in Germany. In 1993, he was appointed full Professor at the , where he chaired the department of Genetics and Evolution between 1997 and 2017. In 2001, he chaired the national center of research ‘Frontiers in Genetics’ and in 2012 the division III of the SNSF. In 2006, he was appointed full Professor at the Federal Institute of Technology (EPFL) in Lausanne, where he leads the Laboratory of Developmental Genomics (UpDUB). Since 2017, he is also a Professor at the Collège de France in Paris.

His research activities are in the fields of embryology, genetics and developmental genomics of mammals, in an evolutionary context. In particular, his laboratory has been closely associated with the structural and functional studies of mammalian Hox genes, by using mouse molecular genetic approaches. Duboule is also active in the communication of science, is member of the Academia Europea as well as of several academies in , France and the Netherland. He is a foreign member of the Royal Society (UK) and of the National Academy of Sciences USA. He has received various scientific prizes and awards, amongst which the Marcel Benoist Prize, the Louis-Jeantet prize for medicine in 1998 or the international INSERM prize in 2010.

Research Support 10 important papers since 2013

Andrey, G., Montavon, T., Mascrez, B., Gonzalez, F., Noordermeer, D., Leleu, M., Trono, D., Spitz, F. and Duboule, D. (2013) A switch between topological domains underlies collinearity in mouse limbs. Science, 2013 Jun 7;340(6137):1234167. doi: 10.1126/science.1234167 De Laat, W. and Duboule, D. (2013) Topology of mammalian developmental enhancers and their regulatory landscapes. Nature, 502(7472), 499-506. Woltering, J., Noordermeer, D., Leleu, M. and Duboule, D. (2014). Conservation and divergence of regulatory strategies at Hox loci and the origin of tetrapod digits. PLoS Biol. (2014) Jan;12(1):e1001773. doi: 10.1371/journal.pbio.1001773. Epub 2014 Jan 21 Andrey G. and Duboule D. (2014) SnapShot: Hox Gene regulation. Cell, 2014 Feb 13;156(4):856- 856.e1. doi: 10.1016/j.cell.2014.01.060. Lonfat, N., Montavon, T., Darbellay, F., Gitto, S. and Duboule, D. (2014). Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci. Science, 346, 1004-1006. Fabre, P., Benke, A., Joye, E., Nguyen Huynh, H., Manley, S. and Duboule, D. (2015) Nanoscale spatial organization of the HoxD cluster in distinct transcriptional states. Proc. Nat. Acad. Sci. USA, Nov 10;112(45):13964-9. doi: 10.1073/pnas.1517972112. Epub 2015 Oct 26 Beccari L, Yakushiji-Kaminatsui N, Woltering JM, Necsulea A, Lonfat N, Rodríguez-Carballo E, Mascrez B, Yamamoto S, Kuroiwa A, Duboule D. A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus (2016) Genes & Dev. May 15;30(10):1172-86. doi: 10.1101/gad.281055.116. Epub 2016 May 19. Deschamps, J. and Duboule, D. (2017). Embryonic timing, axial stem cells, Chromatin dynamics and the Hox clock. (2017). Genes & Dev. 31 (14): 1406-1416. Fabre, P., Leleu, M., B.H., Mormann, Delisle, L., Noordermeer, D., Beccari, L. and Duboule D. (2017). Large-scale genomic reorganization of topological domains at the HoxD locus. Genome Biology, 201718:149 https://doi.org/10.1186/s13059-017-1278-z Rodríguez-Carballo E., Delisle, L., Zhan, Y., Fabre, P., Beccari, L., Necsulea, A.-M., El-Idrissi, I., Nguyen Huynh, T.H., Dekker J. and Duboule D. (2017). The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes. Genes & Dev. In the press