A-1 A-2 A-3 A-4 A-5 A-6 A-7 A-8 A-9 A-10 A-11 A-12 A-13 A-14 A-15 A-16 A-17 A-18 A-19 A-20 A-21 A-22 A-23 A-24 A-25 A-26 NAME OF PRODUCT : TESTOSTERONE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 3-Enol ether OR 4-AD 3- 2.9387 ethoxyandrosta-3,5-dien-17-one Ethanol 8.8160 Triethylamine 0.0723 Sodium Borohydride 0.6782 Hydrochloric acid 2.2605 Water 6.7815 Ethyl Acetate 6.7815 MDC 1.1303 Charcoal + Hyflow 0.0452
Brief Process:
3-Enol etherOR 4-AD 3-ethoxyandrosta-3,5-dien-17-one will be converted into 3-Enol hydroxyOR 4-AD 3-ethoxyandrosta-3,5-dien-17-ol in presence of sodium borohydride and triethylamine, further this compound converts into crude testosterone by treating with 10% hydrochloric acid. This crude material purified by charcoal treatment with organic solvents.
CHEMICAL REACTIONS:
A-27 1. TESTOSTERONE
4- AD -1.3 KG ETHANOL – 3.9 KG
WATER 3.0 KG
SODIUM BOROHYDRIDE- 0.3KG TRIETHYL AMINE - 0.032 KG
HCL (10%) 1.0 KG 9.532 KG CRUDE TESTOSTERON eeTESTOSTERON FILTERATION ML-8.32 kg STRIPPER
1.2 KG
4.5kg Solvent ETHYL ACETATE – 3.0kg (Ethanol)-3.8kg KG MDC – 0.5 KG 4.72 KG CHARCOAL + HYFLOW – 0.02KG ETP / MEE FILTERATION
Charcoal +Hyflow-0.02kg Solvent-3.44kg Residue-0.26kg
Product – 1.0 kg
A-28 NAME OF PRODUCT : TESTOSTERONE PROPIONATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Testosterone 2.2605 MDC 22.605 Pyridine 2.2668 Propionyl chloride 0.9042 Methanol 2.2605
Brief Process:
Testosterone propionate reacts with propionyl chloride and yields testosterone propionate in presence of organic solvent MDC and methylene chloride and pyridine which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-29 TESTOSTERONE PROPIONATE
TESTOSTERONE - 1.0 KG METHANOL - 1.0 KG
PYRIDINE- 1.0 KG
PROPIONYL CHLORIDE -0.4 KG MDC -10.0 KG
13.4 KG CRUDE TESTOSTERON ETESTOSTERON FILTERATION ML-12.40kg STRIPPER
Product – 1.0 kg
Solvent – 11.76 Residue-0.64 kg kg
A-30 NAME OF PRODUCT : TESTOSTERONE UNDECANOATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Testosterone 2.2605 MDC 22.605 Pyridine 2.2605 Decanoyl chloride 0.9042 Methanol 2.2605
Brief Process:
Testosterone propionate reacts with Decanoyl chloride and yields testosterone undecanoate in presence of organic solvent MDC and methylene chloride and pyridine which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-31 TESTOSTERONE UNDECANOTE
TESTOSTERONE - 1.0 KG METHANOL - 1.0 KG
PYRIDINE- 1.0 KG
DECANOYL CHLORIDE -0.4 KG MDC -10.0 KG
13.4 KG CRUDE TESTOSTERON ETESTOSTERON FILTERATION ML- STRIPPER 12.40kg Product – 1.0 kg
Solvent -11.76 Salt - 0.64 kg kg
A-32 NAME OF PRODUCT : TESTOSTERONE CYPIONATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Testosterone 2.2605 MDC 31.647 Pyridine 2.2605 Cyclopropyl propionate chloride 2.2605 Methanol 2.2605
Brief Process:
Testosterone reacts with cyclopropynyl propionate chloride and yields testosterone cypionate in presence of organic solvent MDC and methylene chloride and pyridine which purified by crystalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-33 TESTOSTERONE CYPIONATE
TESTOSTERONE -1.0 KG MDC -7.0 KG
PYRIDINE - 1.0 KG METHANOL-1.0 KG
CYCLOPRONYL PROPINATE CHLORIDE -1.0 KG 11.0 KG CRUDE TESTOSTERON TESTOSTERON FILTERATION ML-10.0kg STRIPPER
Product – 1.0 kg
Solvent -8.82 Salt -1.180 kg kg
A-34 NAME OF PRODUCT : NANDRALONE DECAONATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Nandrolone 2.2605 MDC 9.0420 Pyridine 2.2605 Decanoylchloride 2.2605 Methanol 6.7815 Water 13.5630
Brief Process:
Nandralone reacts with Decanoyl chloride and yields NandraloneDecanoate in presence of organic solvent toluene and methylene chloride and pyridine which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-35 NANDRALONE DECAONATE
NONDRALONE - 1.0 KG MDC - 4.0 KG
PYRIDINE - 1.0 KG METHANOL - 3.0 KG
DECANOYL WATER - 6.0 KG CHLORIDE - 1.0 KG 16.0 KG CRUDE TESTOSTERONE TESTOSTERON FILTERATION ML-15.0 kg STRIPPER
Product – 1.0 kg
Solvent 7.83 kg ML -6.0 kg Residue-1.17
A-36 NAME OF PRODUCT : NANDRALONE PHENYLPROPIONATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Nandrolone 2.2605 MDC 9.0420 Pyridine 2.2605 Phenylpropionylchloride 2.2605 Methanol 5.6513 Water 13.6530
Brief Process:
Nandralone reacts with Phenylpropionyl chloride and yields Nandralonephenylpropionate in presence of organic solvent toluene and methylene chloride and pyridine which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-37 NANDRAOLONE PHENYL PROPIONATE
NONDRALONE - 1.0 KG MDC - 4.0 KG
PYRIDINE - 1.0 KG METHANOL - 2.5 KG
PHEYNYL PROPIONYL WATER - 6.0 KG CHLORIDE - 1.0 KG 15.5 KG CRUDE TESTOSTERON TESTOSTERON FILTERATION ML-14.50 kg STRIPPER
Product – 1.0 kg
Solvent -7.38 Effluent-6.0 k g kg Residues-1.12 kg
A-38 NAME OF PRODUCT : TRENBOLONE ACETATE QUANTITY TO BE PRODUCED : 0.05 MT/Month MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Trenbolone 2.2605 Acetic anhydride 4.9731 Pyridine 4.9731 Sodium Chloride Hydrochloric acid 2.2605 Potable water 22.6050 25% Ammonia 0.2261
Brief Process:
Trenbolone reacts with acetic anhydride and yields tranbolone acetate, which precipitated by sodium chloride and hydrochloric acid solution and finally purified in organic solvents by charcoalization.
CHEMICAL REACTIONS:
A-39 TRENBOLONE ACETATE
AMMONIA - 0.1 KG
TRAMBOLONE -1.0 KG
PYRIDINE –2.2 KG ACETIC ANHYDRIDE - 2.2 KG
HCl - 1.0 KG WATER -10.0 KG
16.5 KG CRUDE TRAMBOLONETESTOSTE RTESTOSTERONFILTERATION Mother Liquor-15.5 kg STRIPPER
Product – 1.0kg
Solvent – 4.32 kg Effluent- 11.18 kg
A-40 NAME OF PRODUCT : TRENBOLONE ENANTHATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Trenbolone 2.2605 Heptanoic Anhydride / 4.9731 Enthanate Anhydride Pyridine 5.4252 Sodium Chloride Hydrochloric acid 2.2605 Potable water① 22.6050 25% Ammonia 0.2261
Brief Process:
Trenbolone reacts with Heptanoic Anhydride and yields Enanthate, which precipitated by sodium chloride and hydrochloric acid solution and finally purified in organic solvents by charcoalization.
CHEMICAL REACTIONS:
A-41 TRENBOLONE ENTHANATE
AMMONIA - 0.1 KG
TRAMBOLONE -1.0 KG
PYRIDINE –2.4 KG ENANTHIC ANHYDRIDE - 2.2 KG
HCl - 1.0 KG WATER -10.0 KG
16.7 KG CRUDE TRAMBOLONETESTOSTE RTESTOSTERONFILTERATION Effluent-15.7 kg
Product – 1.0 kg
A-42 NAME OF PRODUCT : METHANDIENONE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Methyl testosteronum 2.939 Toluene 20.345 2,3dicyno-5,6- 2.261 dichlorobenzoquinone (DDQ) p-Nitrophenol 2.261 Sodium hydroxide 4.521 Potable water 56.513 Sodium sulphite 22.605 Methanol 1.808 Activated charcoal 0.226 Isopropyl Ether 6.782 n-hexane 4.521 Ethyl Acetate 15.824
Brief Process:
Methyltestosteronum compound converted into crude methandienone in presence of p- nitrophenol and 2,30dicyno-5,6-dichlorobenzoquinone (DDQ) which is isolated by concentrating organic layer under vacuum. This crude material is purified in solvent by using activated alumina and charcoal
CHEMICAL REACTIONS:
A-43 METHANDIENONE
METHYL TESTOSTERONEM -1.3KG TOLUENE-9.0 KG
WATER - 15KG SODIUM HYDROXIDE – 2.0 KG
2,3DICYNO-5,6 DICHLORO PARANITRO PHENOL - 1.0 KG BENOQUINONE - 1.0 KG (DDQ) 29.3 KG CRUDE
FILTERATION ML-39.3 kg STRIPPER
1.0 KG
MEE Solvent – 19.11kg 20.19 kg (Toluene – 8.3kg IPE- 3.0KG HEXANE (2.0 KG) IPE-2.4kg 12.0 KG Hexane-1.66kg ETHYL ACETATE -7.0KG Ethyl Acetate- 6.75kg) Residue – 0.30kg PURIFICATION 1.0 KG Sodium Sulphite – 10 Charcoal – 0.1 21.9 KG Water – 5 .0 kg Methanol – 0.8 Water – 5.0kg DISTILLATION
Charcoal-0.1 Methanol-0.8 Effluent-20.0
Product – 1.0kg
A-44 NAME OF PRODUCT : OXYMETHOLONE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Mestanolone 2.486 N,N-Dimethylformamide 12.4328 Ethylenediaminetetraacetic acid 0.0025 disodium salt Sodium methanolate 0.6216 Ethyl formate 0.9494 Water① 37.2983 Dichloromethane 14.919 Sodium carbonate 0.2034 98%Sulfuric acid 2.4866 Sodium Bicarbonate 0.2034 Methanol 13.563 Charcoal 0.2487
Brief Process:
Mestanolone is reacted with ethylenediamainetetraacetic acid disodium in presence of dimethyl formamide, sodium methoxide and ethyl formate and yields crude oxymetholone which is purified in organic solvent by charcoalization in pure form.
CHEMICAL REACTIONS:
A-45 OXYMETHALONE
DI CHLORO METHANE-6.6 KG
MESTONOLONE -1.1KG N,N DIMETHYL FORMAMIDE-.5.5 KG
WATER-16.5 KG SODIUM METHOXIDE-0.275 KG
EDTA SODIUM SALT-0.0011KG MTHYL FORMATE -0.42 KG SODIUM CARBONATE -0.09 KG 30.4861 KG
SULPHURIC ACID -1.1 KG EXTRACTION ML- MEE SODIUM BICARBONATE 21.4961 KG MEE 0.09 KG 15.18 KG WATER-5.0 KG ORGANIC LAYER
EXTRACTION SOLVENT- ML -13.0911 8.405kg MDC-10.6 kg
MEE WATER +PRODUCT (4.58 KG)
FILTERATION
ML-3.08 KG MEE METHANOL-6.0 KG CRUDE CHARCOAL-0.11 KG (7.61 KG)
FILTERATION 6.61 KG
Product – 1.0kg
STRIPPER
METHANOL RESIDUE (6.4 KG) (0.21KG)
A-46 -NAME OF PRODUCT : STANOZOLOL MAXIMUM QUANTITY TO BE 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Oxymetholone 2.4866 Dichloromethane① 17.049 diatomite 0.1243 Dichloromethane② 3.3026 Hydrazine hydrate 0.5583
Brief Process:
Oxymetholone is reacted with diatomite and then with 80%hydrazine hydrate in presence of methylene chloride and yields stanozolol.
CHEMICAL REACTIONS:
A-47 STANOZOLOL
OXYMETHOLONE -1.1 KG DIATOMITE -0.055 KG
MDC – 7.7 KG
8.855 KG
FILTERATION
MDC - 1.461 KG SOLID -10.563 KG HYDRAZINE - 0.247 KG
DISTLLATION MDC -7.6 KG
MDC+PRODUCT -2.963 KG
FILTERATION
MDC-1.961 KG
Product – 1.0 kg
A-48 NAME OF PRODUCT : TIBOLONE MAXIMUM QUANTITY TO BE 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Tibolone-3-Double etherification 2.7126 Anhydrous ethanol 40.6890 Oxalic acid 0.8138 Sodium bicarbonate 3.3908 Deionized water 79.1175 Pyridine 0.0271 Acetone 11.3025 Dichloromethane 14.6933 Activated carbon 0.1130
Brief Process:
Tibolone-3-double etherification compound is reacted with oxalic acid in ethanol and neutralize with sodium bicarbonate which is converted in tibolone.
CHEMICAL REACTIONS:
A-49 TIBOLONE
ETHANOL -18.0 KG TIBOLONE-3-DIBASIC ETHERIFICATION LOPRAMIDE -1.2KG WATER-19.2 KG SODIUM BICARBONATE -1.5 KG
OXALIC ACID -0.36 KG
40.26 KG
PYRIDINE -0.012 KG FILTERATION ACETONE -5.0 KG 36.21 KG MEESTRIPPER MDC -6.5 KG 15.612 KG CARCOLE - 0.05 KG CRUDE
Ethanol – 15.41kg ML-19.71 kg
MEE
FILTERATION
ML –14.562 KG Charcoal-0.05 KG STRIPPER
Product – 1.0kg ACETONE MDC SOLID 7.0 KG 7.562 0.05 KG)
A-50 NAME OF PRODUCT : HYDROXYPROGESTERONE CAPROATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 17α-Hydroxyprogesterone 2.2605 n-Hexanoic acid 4.5210 Pyridine 1.8084 p-Toluenesulfonic acid 0.1808 Toluene 13.5630 Ethanol 5.6513 hydrochloric acid 0.3391 Ethanol 22.6050 Activated charcoal 0.2261
Brief Process:
Hydroxyprogesterone is reacted with n-hexanoic acid in presence of pyridine and p- tolunesulfonic acid then extracted in organic solvent as hydroxyprogesteronecaproate.
CHEMICAL REACTIONS:
A-51 HYDROXY PROGESTERONE CAPROATE
HEXANOIC ACID - 2.0 KG HYDROXY PROGESTERONE - 1.0KG P.T.S.A - 0.08 KG
PYRIDINE -0.80 KG ETHANOL- 2.5 KG
TOLUENE- 6.0 KG HYDROCHLORIC ACID 30% - 0.15 KG
12.53 KG FILTERATION 10.18 KG STRIPPERMEE ETHANOL -10.0 KG 12.45 KG ML CHARCOAL- 0.1 KG CRUDE
Solvent-8.35 kg SOLID RESIDUE - 1.83 kg
FILTERATION / DISTILLATION ML -11.45 KG STRIPPER
Product – 1.0 kg ETHANOL SOLID 9.85 KG 1.40KG
A-52 NAME OF PRODUCT : NORATHISTERONE ACETATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Norethisterone 2.486 toluene 22.6050 Acetic anhydride 12.432 Triethylamine 0.6782 Catalyst DMAP 10% hydrochloride acid water 24.8655 solution Charcoal / Hyflow 0.2261 Methanol 24.8655
Brief Process:
Norathisterone is reacted with acetic anhydride in presence of triethylamine in toluene and yields norathisterone acetate.
CHEMICAL REACTIONS:
NORETHISTERONE -1.1KG HCL 10% - 11.0 KG
TOLUENE - 10.0 KG T.E.A. -0.3 KG
ACETIC ANHYDRIDE -5.5 KG
27.9 KG EXTRACTION / FILTERATION 15.75 KG STRIPPER DISTILLATION ML METHANOL - 11.0 KG 16 KG CHARCOAL-0.1 KG 13.25 KG Toluene - CRUDE 10.0 KG Effluent + Acetic SOLID RESIDUE Anhydride-10.0kg 0.75 KG
STRIPPER
Product – 1.0kg
METHANOL -12 kg SOLID RESIDUE CHARCOAL-0.1 0.15 KG
A-54 NAME OF PRODUCT : NORATHISTERONE ENANTHATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Norethindrone 2.486 Dichloromethane 22.6050 DMAP 3.0517 Heptanoic anhydride 3.6168 Sodium bicarbonate 3.7298 Water 74.5965 hydrochloric acid 7.4597 IPE 2.4866
Brief Process:
Norathisterone is reacted with heptanoic anhydride in presence of DMAP in methylene chloride and yields norathisteroneenanthate. Which is purified by charcoal treatment in chlorinated organic solvent and isolated
CHEMICAL REACTIONS:
DI CHLORO METHANE -10.0 KG
NORETHISTERONE -1.1KG DMAP -1.35 KG
HEPTANOIC ANHY -1.60 KG
14.05 kg
HYDROCHLORIC ACID (3.3 KG) EXTRACTION 1.85 KG SODIUM BICARBONATE MEEMEE (1.65 KG) 12.2 KG WATER (33.0 KG) ORGANIC LAYER
EXTRACTION SOL.+RESIDUE ( 7.2 KG)
ORGANIC LAYER WATER (33 KG) ML (38.35 KG) (11.8 KG)
DISTILATION Di Chloro Methane (9.5 KG) Residue – 0.6 kg
IPE (1.1 KG) CRUDE (2.1 KG)
FILTER / DISTILLATION IPE – 0.98, Residue -1.2 kg
SOLID PRODUCT (1.0 KG)
A-56 NAME OF PRODUCT : LEVONORGESTREL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Methoxydienone 2.7126 potassium hydroxide 8.1378 Tetrahydrofuran 29.3865 Acetone 1.8084 hydrochloric acid 17.767 acetylene 4.5210 Nitrogen Acetone 24.4134 MDC 61.0355 Water 12.4328
Brief Process:
Methoxydienone is reacted in tetrahydrofuran with potassium acetylene solution previously prepared by acetylene and potassium hydroxide mixture which is neutralize with hydrochloric acid and finally isolated as levonorgestrl from acetone and purified by charcoalization in oraganic solvent.
CHEMICAL REACTIONS:
A-57 LEVONORGESTEREL
METHOXYDIENONE (1.2 KG)
ACETONE (0.80 KG) POTASSIUM HYDROXIDE (3.6 KG)
ACETYLENE (2.0 KG) THF (13.0 KG)
20.6 KG
DISTILLATION THF(10.0 KG)
HCL (7.86 KG) 10.6 KG
DISTILLATION
WATER (13.46KG) THF (5.0 KG) (5.5KG)
FILTERATION Effluent(17.86 KG)
ACETONE (10.0 KG) CRUDE (1.1 KG) MDC (27.0 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) MDC ACETONE (27.0 KG) (10.0 KG)
Residues-0.1 kg
A-58 NAME OF PRODUCT : DESOGESTREL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Ethyl ketone 2.9387 Lithium 1.4693 Tetrahydrofuran 21.1583 Ethidene diamine 79.3436 Nitrogen Acetylene gas 3.3908 Absolute ethyl alcohol /methanol 169.537 Potable water Ethyl acetate 67.8150 Anhydrous magnesium sulfate Active charcoal 0.2261 Hexane 14.6933 HCl 17.7675
Brief Process:
Acetylene lithium solution is added to ethyl ketone compound previously dissolved in tetrahydrofuran in presence of lithium and ethylene diamine yields desogestrel and finally purified in organic solvents.
CHEMICAL REACTIONS:
A-59 DESOGESTREL
ETHILENE DIAMINE (35.1 KG) ETHYL KETONE (1.3 KG)
ETHANOL (75.0 KG) LITHIUM (0.65 KG)
ACETYLENE (1.5 KG) THF (9.36 KG) ETHYL ACETATE (30.0 KG) 152.91 KG
EXTRACTION ML 99.27 KG)
HCL (7.86 KG) ORGANIC LAYER (61.5 KG) STRIPPER CONCENTRATE BY 60.09kg DISTILLATION
(1.41 KG) ML -84.16 THF-9.20 kg kg Ethanol-66.0
MEE FILTERATION
RESIDUE- 0.30 KG
HEXANE (6.5 KG) CRUDE (7.71 KG) CHARCOLE/HYFLOW (0.10 KG)
DISTILLATION
HEXANE (6.5 KG) SOLID PRODUCT CHARCOAL / hyflow-0.10 (1.0 KG) RESIDUE – 0.11 KG
A-60 NAME OF PRODUCT : DROSPIRENONE QUANTITY TO BE PRODUCED : 0.02 MT/Month MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month Quantity in MT/Month (MAXIMUM) D11 OR 3β,5-dihydroxy- 0.0200 2.2605 6β,7β;15β,16β-dimethylene- 5β,17α-pregna-21,17- carbolactone Tetrahydrofuran 0.532 6.0129 p-toluenesulfonic acid 0.0040 0.4521 Triethylamine 0.0040 0.4521 Silica gel Activated charcoal 0.0020 0.2261 Tetrahydrofuran Isopropyl acetate 0.0166 1.1981 Dichloromethane 0.0560 6.3294 Methanol 0.0480 5.4252
Brief Process:
D11 OR 3β,5-dihydroxy-6β,7β;15β,16β-dimethylene-5β,17α-pregna-21,17-carbolactone is dissolved in THF converted into ketone and yields drospirenone in presence of p-toluene sulfonic acid and triethylamine. This crude material is purified with activated charcoal treatment in organic solvents.
CHEMICAL REACTIONS:
A-61 DROSPIRENONE
D 11 (1.0 KG)(3β,5-dihydroxy 6 β,7 β17 β,16 β-dimethylene-5 β,17α- pregna21,17,carbolactone ) PTSA (0.20 KG)
TEA (0.20 KG) THF (1.33 KG)
2.73 KG
CHARCOAL/HYFLOW (0.10KG) THF (1.33 KG) KG) METHANOL (2.4 KG) 9.89 KG ISO PROPIL ACETONE (0.53 KG) MDC (2.8 KG)
FILTERATION CHARCOAL/HYFLOW (0.1 KG)
ORGANIC LAYER (9.79 KG)
DISTILATION Methanol – 2.35 MDC-2.75 Residue – 2.19
(2.50 KG)
FILTER Effluent (1.5KG)
SOLID PRODUCT (1.0 KG)
A-62 NAME OF PRODUCT : PROGESTERONE QUANTITY TO BE PRODUCED : 1 MT/Month MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month Quantity in MT/Month (MAXIMUM) Progesterone intermediate OR 1.200 2.7126 (20S)-3-oxopregn-4-ene-20- carboxaldehyde, 3-oxopregn-4- ene-20β-carboxaldehyde DMF 5.70 12.88 Cuprous chloride 0.600 1.3563 Dichloromethane① 4.680 10.5791 Acetonitrile Concentrated sulfuric acid 0.200 0.4521 Potable water① 1.800 4.0689 Dichloromethane② 9.380 21.2035 Potable water② 3.00 6.7815 Potable water③ 6.00 13.5630 NaCl Potable water ④ Methanol 6.00 13.5630 Acetone 6.00 13.5630 Charcoal / Hyflow 0.100 0.2261 Brief Process: Progesterone intermediate solution prepared in dichloromethane acetonitrile and added in cuprous chloride solution prepared in DMF under nitrogen flushing. This produce progesterone crude and this material is isolated by adding 10% sulphuric acid solution and extracted in organic solvents. Crude material is purified in solvent by charcoal treatment.
CHEMICAL REACTIONS:
A-63 PROGESTERONE
ACETONITRILE (0.072 KG) PROGESTERONE INTERMEDIATE (1.2 KG)(20S)-3- oxopregn-4ene-20-carboxaldehyde) CUPROUS CHLORIDE (0.60 KG)
DMF (5.7 KG) MDC (4.68 KG)
12.252 KG
SULPHURIC ACID(0.20KG) MDC (9.38 KG)
WATER(1.80 KG) 26.632 KG WATER (3.0 KG)
SEPERATION Effluent (5.632 KG)
WATER (6.0 KG) ORGANIC LAYER (27.0 KG)
SEPERATION Effluent (6.0 KG)
DISTILLATION (21.0 KG) MDC-13.92 Effluent – 4.58
METHANOL (6.0 KG) (8.50 KG)
Methanol – 5.9, Residue-1.3
ACETONE (6.0 KG) CRUDE (7.40 KG) CHARCOLE/HYFLOW (0.10 KG) FILTERATION/DISTELLATION
SOLID PRODUCT (1.0 KG) Acetone SOLID RESIDUE (5.9 KG) (0.50 KG)
A-64 NAME OF PRODUCT : ALLYLESTRENOL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Estrenone OR 2.2605 17-oxo-4-estrin Tetrahydrofuran 10.5678 3-bromopropene 0.0520 3-chloropropene 2.2605 Magnesium chips 0.5199 Ammonium chloride 9.0420 Potable water 11.3025 Dichloromethane 33.2294 Isopropyl ether 9.0420 Charcoal / Hyflow 0.2261
Brief Process:
Magnesium chips are taken in tetrahydrofuran in GLR and 3-bromopropene and 3— chloropropene added. This reagent is reacted with estrenone or 17-oxo-4-estrin compound and yields allylestrenol and finally purified in solvents treating with carbon.
CHEMICAL REACTIONS:
A-65 ALLYLESTRENOL
MAGNESIUM CHIPS(0.23 KG) CHLOROPROPENE (1.0 KG) THF (2.875 KG)
THF (1.8 KG) BROMOPROPENE (0.023 KG) (2.8 KG) (3.128 KG)
ESTRENONE (1.0 KG) 5.928 KG THF (1.0 KG)
NH4Cl (4.0 KG) 28.628 KG MDC (11.7 KG) WATER (5.0 KG)
SEPERATION Effluent (19.128 KG) (9.5 KG)
DISTIL0.-3.9ATION MDC (3.0 KG) MDC-11.7kg , Effluent-6.328kg
CHARCOLE/HYFLOW (0.10 KG) (8.20 KG) IPE (4.0 KG)
FILTERATION/DISTILLATION
SOLID PRODUCT (1.0 KG) IPE-3.9 , MDC-2.9 SOLID RESIDUE Charcoal / (0.30 KG) Hyflow-0.1
A-66 NAME OF PRODUCT : GESTODENE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 15α-acetoxy-3-ethoxy-18- 3.1649 methyl-estra-3,5-dien-17-one THF 13.9247 1.6mol/L Butyl lithium 5.3800 Acetylene gas 4.5210 Pyridine 0.0158 Hydrochloric acid 7.5953 Potable water 6.3294 Ethyl acetate 11.3025 20% NaOH 0.0045 THF 20.8870 Ethyl Acetate 28.9344 Water 0.2261 Acetone 27.1260 Charcoal / Hyflow 0.2261
Brief Process:
A solution of butyl lithium in THF and acetylene is reacted with solution of 15α-acetoxy-3- ethoxy-18-methyl-estra-3,5-dien-17-one 15 previously prepared in THF in presence of pyridine and yields gestodene crude. Which is extracted in ethyl acetate and purified in organic solvents by charcoal treatment
CHEMICAL REACTIONS:
A-67 GESTODENE 15α-acetoxy-3- ethoxy-18-methyl- THF(9.24KG) estra- 3,5-dien-17-one (1.4 KG) BUTYL LITHIUM (2.38 KG)
ACETYLENE (2.0 KG) THF (6.16 KG)
PYRIDINE (7.567 KG) (13.62 KG) (0.007KG)
HCL (3.36 KG) ETHYL ACETATE (12.8 KG) 21.187 KG WATER (2.80 KG) ETHYL ACETATE (5.0KG ) SEPERATION
NaOH(0.002 KG) 40.147 KG ORGANIC LAYER (20.48 KG)
AQUAS LAYER(24.769 KG)
WATER (0.1 KG) EXTEACTION Effluent (12.20 KG) ORGANIC LAYER (12.569 KG)
33.049 KG DISTILLATION Ethyl Acetate-17.50kg Effluent-14.449kg ACETONE (12.0 KG)
CHARCOLE/HYFLOW CRUDE (1.1 KG) (0.1 KG) Acetone (11.75 KG) DISTILLATION Residue-0.44 kg SOLID PRODUCT (1.0 KG)
A-68 NAME OF PRODUCT : LYNESTRENOL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 17alpha-hydroxy-19-norpregn-4- 3.1647 en-20-yn—3one-cyclic ethylenedithioacetal liquid ammonia 11.3025 Li 0.3119 anhydrous cupric sulfate 0.0003 THF① 8.3186 ethanol 3.6168 THF②/water 2.1475 Ethanol 15.8235 Water 0.1130 Charcoal / Hyfow 0.2261
Brief Process:
In a solution of lithium in liquid ammonia at lower temperature prepared and a solution of 17alpha-hydroxy-19-norpregn-4-en-20-yn—3one-cyclic ethylenedithioacetal in THF previously prepared added in it so crude lynestrenol is produced and which is purified by organic solvent using carbon as decolouring agent.
CHEMICAL REACTIONS:
A-69 LYNESTRENOL
17α-hydroxy19-norpregn- 4-en-20-yn-3-one- LIQUID AMMONIA (5.0 KG) cyclicethylenedithoiacetyl (1.4 KG) LITHIUM (0.138 KG)
THF (3.68 KG) CUPRIC SULPHIDE (0.000115 KG) (5.08 KG) (5.1381 KG)
MIXING
WATER (0.05 KG) ETHANOL (1.60 KG) 12.82 KG THF (0.95 KG) DISTILLATION ETHANOL-1.58 kg ETHANOL (7.0 KG) 1.16 KG EFFLUENT-10.07 KG CHARCOL/HYFLOW (0.10 KG)
DISTILLATION ETHANOL-6.70 kg CHARCOAL / HYFLOW-0.10kg RESIDUE-0.45kg SOLID PRODUCT (1.0 KG)
A-70 NAME OF PRODUCT : EXEMESTANE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Trifluoro Methane Sulfonic Acid 0.0294 BSTFA 12.1660 Toluene 27.1260 6-methylene-antrest-4ene-3,17-dione 2.9387 Chloranil 2.7352 Ethyl Acetate 33.9075 NaOH 6.2164 Water 135.63 NaCl 19.8924 Ethyl Acetate 11.3025 IPE 4.5210 n-Hexane 3.3908 Acetonitrile 9.9462 Charcoal/Hyflow 0.2261
Brief Process:
In a solution of lithium in liquid ammonia at lower temperature prepared and a solution of 17alpha-hydroxy-19-norpregn-4-en-20-yn—3one-cyclic ethylenedithioacetal in THF previously prepared added in it so crude lynestrenol is produced and which is purified by organic solvent using carbon as decolouring agent.
CHEMICAL REACTIONS:
A-71 EXEMESTANE
TRIFLUORO METHANE SULPHONIC ACID (0.013 KG) TOLUENE (12 KG)
BSTFA (5.382 KG) 6-methylene-antrest-4ene-3,17-dione (1.3 KG)
CHLORANIL (1.21 KG)
19.905 KG
FILTERATION EFFLUENT-7.575 kg
ETHYL ACETATE (15.0 KG) 27.33 KG
NaOH (2.75 KG) SEPERATION/EXTRACTION EFFLUENT (6.905 KG)
WATER (22.25 KG) ORGANIC LAYER (54.225 KG)
NaCl (8.8 KG) DISTILLATION
ETHYL ACETATE(5.0 KG) DISTILLATION Ethyl Acetate-19.50kg IPE (2.0 KG) (63.225 KG) Effluent-10.5kg DISTILLATION n-HEXANE (1.5 KG) Effluent -32.075kg ACETONITRILE (4.4 KG) CRUDE (5.65 KG)
CHARCOLE/HYFLOW (0.10 KG)
FILTERATION/DISTELLATION SOLVENT (4.0 KG) CHARCOAL-0.10 KG SOLID PRODUCT SOLID RESIUDE-0.08 KG (1.0 KG)
A-72 NAME OF PRODUCT : ESTRADIOL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Estrone 2.3735 Methanol 40.689 Potassium hydroxide 0.1921 Potable water① 48.0582 Potassium borohydride 1.9214 Acetic anhydride Ethanol / Methanol 12.433 Charcoal / Hyflow 0.2261 Brief Process:
Estron is dissolved in methanol and potassium hydroxide solution is added to this mass in presence of potassium borohydride, finally neutralized with acetic acid & isolated from solvent methanol or ethanol. Which yields estradioal.
CHEMICAL REACTIONS:
A-73 ESTRADIOL POTASSIUM HYDROXIDE (0.085 KG) ESTRONE (1.05 KG) WATER (1.26 KG) METHANOL (18.0 KG) POTASSIUM BOROHYDRIDE (0.85 KG) (19.05 KG) (2.195 KG)
21.245 KG
WATER (20.0 KG) DISTILLATION Methanol – 17.5kg ETHANOL (5.5 KG) 26.8 KG Residue-2.545kg
CHARCOL/HYFLOW (0.10 KG)
FILTERATION/DISTILLATION Ethanol (5.35 KG) Effluent – 20.45kg SOLID PRODUCT (1.0 KG)
A-74 NAME OF PRODUCT : ESTRINOL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 3,17 beta-diacetoxy-16 2.9387 alpha,17alpha-epoxy-estra- 1,3,5(10)-triene CAS No: 69744-63-4 Ethanol 23.2832 Potassium borohydride 0.5877 Sodium hydroxide 2.5860 Potable water 5.8773 Glacial acetic acid 4.9957 Ethanol 33.9075 Acetone 5.6213 Brief Process:
A alkaline solution of Potassium borohydride is prepared and epoxide compound 3,17 beta- diacetoxy-16 alpha,17alpha-epoxy-estra-1,3,5(10)-triene is added in it which is neutralized with acetic acid yields Estrinol which is purified in solvent.
CHEMICAL REACTIONS:
A-75 ESTRINOL
EPOXIDE COMPOUND(3,17beta- diacetoxy-16 -17α-epoxy- SODIUM HYDROXIDE (1.144 KG) esterA-1,3,5,(10)triene (1.3 KG) WATER (2.6 KG)
ETHANOL (10.3 KG) POTASSIUM BOROHYDRIDE (0.26 KG) (11.6 KG) (4.004 KG)
-16.714ACETIC ACID 15.604 KG (2.21 KG) FILTERATION
ETHANOL (15 KG) CRUDE Effluent-16.714 kg (17.814KG)
ACETONE (2.5 KG) DISTILLATION Ethanol & Acetone 17.4 KG) RESIDUE-0.2 KG SOLID PRODUCT (1.0 KG)
A-76 NAME OF PRODUCT : ESTRADIOL CYPIONATE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 3,17（β）-di- 2.4866 cyclopentanepropionate Methanol 15.8235 Potassium carbonate 1.1303 Water 11.3025 Charcoal / Hyflow 0.2261 Methanol 15.8235 Water 10.1723 Brief Process:
3,17（β）-di-cyclopentanepropionate is added in alkaline solvent which converts into estradiolcypionate& finally purified with organic solvent mixture.
CHEMICAL REACTIONS:
A-77 ESTRADIOL CYPIONATE
METHANOL (7 KG) 3,17 β dicyclopentomepropsonate (1.1 KG)
POTASSIUM SORBANTE (0.5 KG)
WATER (5.0 KG) WATER (2.5 KG)
15.65 KG
FILTERATION ML STRIPPER CHARCOLE/HYFLOW (14.5 KG) (0.1KG) CRUDE ( 10.25 KG) WATER (2.0 KG)
METHANOL Methanol 7.0kg (7.0 KG) DISTILLATION FILTERATION MEE 7.5 kg SOLID PRODUCT (1.0 KG) Methanol (7.0 KG)
CHARCOAL/HYFLOW (0.1KG)
SOLID RESIUDE- 2.15 kg
A-78 NAME OF PRODUCT : ETHYNYLESTRADIOL MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Estrone 2.7126 KOH 4.0689 Tetrahydrofuran 7.7580 Acetone 1.9214 Hydrochloric acid 19.3680 Acetylene 2.2605 Dichloromethane 2.7126 Water 2.7239 Ethanol 2.7126 Charcoal / Hyflow 0.2261 Brief Process:
Estrone is reacted in alkaline media with acetylene in solvent mixtures and yields ethinylestradiol, crude material is purified with charcoal treatment.
CHEMICAL REACTIONS:
A-79 ETHINYL ESTRADIOL
POTASSIUM HYDROXIDE (1.8 KG) ESTRONE (1.2 KG) THF (1.716 KG)
THF (1.716 KG) ACETONE (0.85 KG)
(2.916 KG) (5.366 KG) ACETYLENE (1.0 KG)
HCl (8.568 KG) 16.855 KG WATER(0.005 KG) MDC(1.2 KG) DISTILLATION Effluent 13.62 KG (4.432 KG)
FILTERATION/DISTILLATION Effluent - (12.543 KG) ETHANOL (1.2 KG) CRUDE (3.58 KG) CHARCOL/HYFLOW(0.1 KG)
WATER (1.2 KG) FILTERATION SOLVENT+WATER (2.58 KG)
SOLID PRODUCT (1.0 KG) STIPPER
Ethanol R ESIDUE (1.18 KG) (1.40KG)
A-80 NAME OF PRODUCT : MIFEPRISTONE MAXIMUM QUANTITY TO BE : 2.2605 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) 11beta-<4-(dimethylamino)phenyl>- 2.2605 3,3-(ethylenedioxy)-17alpha- (1propynyl)estra-9—en- 5alpha,17beta-diol,11beta-[4- (dimethyl)phenyl]-3,3- (ethylenedioxy)-17alpha- (propynyl)estra-9en-5alpha,17beta –diol. Glacial acetic acid 11.8676 Water 3.5603 Ammonia water 20.9096 Brief Process:
11beta-<4-(dimethylamino)phenyl>-3,3-(ethylenedioxy)-17alpha-(1propynyl)estra-9—en- 5alpha,17beta-diol,11beta-[4-(dimethyl)phenyl]-3,3-(ethylenedioxy)-17alpha-(propynyl)estra- 9en-5alpha,17beta –diol is hydrolyzed with reacted with acidic medium solution and yields mifeprostone which is isolated in alkaline solution. crude material is purified with charcoal treatment in solvents.
CHEMICAL REACTIONS:
A-81 MIFEPRISTONE
(dimethylamino)phenyl-3- 3(ethylenedioxy)-17α- (iprophynyl)estra-9-en-5-alpha ,17 beta-diol,11beta-(4- (dimethyl)phenyl -3- 3(ethylenedoxy)-17-alpha- (propynyl)estra-9-en-5alpha-17- GLACIAL ACETIC ACID (5.25 KG)
7beta-diol (1.05 KG) WATER (1.575 KG)
AMMONIA WATER(9.25 KG)
17.125
FILTER Effluent (15.925 KG) ETHYL ACETATE (4.5 KG) CRUDE (1.2 KG) CHARCOLE/HYFLOW (0.1KG)
FILTERATION/DISTILLATION
SOLID PRODUCT (1.0 KG) RECOVERD RESIDUE (0.10KG) SOLVENT (4.70 KG)
A-82 OXANROLONE
OXANDROSOURIC ACID (1.1 KG)
SODIUM BOROHYDRIDE (0.2 KG) ETHANOL (4.0 KG)
HCL 20 %(2.0 KG) WATER (4.0 KG)
NaOH 25 %(0.4 KG) 11.7 KG
FILTERATION Effluent -10.6 kg ETHANOL(7.0 KG) CRUDE CHARCOL/HYFLOW (1.1 KG) (0.10 KG)
DISTILLATION/FILTERATION
CRUDE PRODUCT ETHANOL(7.0 KG) (1.0KG) CHARCOAL-0.10 kg RESIDUE -0.10kg
A-83 MEDROXY PROGESTRRONE ACETATE
METHENYL ACETATE (1.2 KG) DMF (2.5 KG)
5%PALLADIUM CHAROROL (0.2 KG)
CYCLOHEXANE (1.0 KG)
4.9 KG
FILTERATION
HCL30%(0.13 6.18 KG WATER (1.0 KG) KG) SODIUM BICARBONATE (0.15 KG)
MDC (4.0 KG) FILTERATION EFFLUENT-5.03 kg
METHANOL (5KG) CRUDE (1.15) kg
CHARCOLE/HYFLOW (0.1KG) DISTILLATION/FILTERATION MDC+METHANOL -8.7 KG CHARCOAL-0.1 KG CHARCOLE/HYFLOW SOLID RESIDUE-0.55 KG (0.1KG) SOLID PRODUCT (1.0 KG)
A-84 MEGESTEORL ACETATE
PALLACCLIUM CARBN (0.11 KG) INTERMEDIATE (1.1 KG)
4-METHYL-1-CYCLOHEXANE RETUMOL (3.1 KG) (0.11 KG) SODIUM ACETATE (0.11 KG) WATER (1.5 KG)
6.03 KG
FILTER Effluent (4.88 KG) METHANOL(6.5 KG) CRUDE (1.15 KG )
CHARCOLE/HYFLOW (0.1KG)
FILTER
SOLID PRODUCT (1.0 KG) Methanol (6.5 KG) RESIDUE (0.25KG)
A-85 ABIRATERONE ACETATE
DMAP (0.125 KG) DHEA (1.25 KG)
WATER (25.0 KG) TRIFLUOROMETHANE SULPHAMIC ACID ANHYDROUS (1.65 KG) (1.3 KG) MDC (26.0 KG) POTASSIUM ACETATE (0.55 KG) 42.065 KG
SEPERATION/EXTRACTION Effluent (12.75 KG) CHARCOLE/HYFLOW(0.1 KG) 29.365 KG
DISTILLATION STIPPER DIETHYL(3-PYRIDYL)BORANE (0.495 KG) (26.465) ETHYL ACETATE (7.0 KG) THF (8.45 KG) Na2HCO3 (1.825KG)
WATER (15.4KG) 2.9 KG
BISPALLADIUM CHLORIDE(0.01625 KG) MDC SOLID (24.80 KG) (1.65 KG)
EXTRACTION/SEPRATION Effluent ETHYL ACETATE(2.46 KG) (21.43 KG) ETHYL TRIFLUORO ACETIC ACID (0.46 KG) ACETATE LAYER (7.53 KG) METHYL TERTIARY BUTYL ETHER (6.05 KG)
16.5 KG
FILTERATION Effluent
15.20 KG)
SODIUM CARBONATE(1.125 KG) 1.3 KG DIATOMITE(1.25 KG)
A-86 WATER(20.5 KG) MDC(41.0 KG)
EXTRACTION Effluent (20.0 KG)
ORGANIC LAYER (65.175 KG)
ACETONITRILE(2.895 EXTRACTION MDC -63.975 L KG) FILTER ACETIC ETHER (3.75 KG) (1.2 KG)
CHARCOAL/HYFLOW(0.1 Effluent- 6.20kg FILTERATION KG) CHARCOL-0.1kg RESIDUE-0.645kg SOLID PRODUCT (1.0 KG)
A-87 NAME OF PRODUCT : BETAMETHASONE MAXIMUM QUANTITY TO BE : 8.487MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) DB-11 8.49 HF 70% 25.46 Dichloromethane 11.29 Methanol 33.95 Water 84.87 Charcoal / Hyflow 0.42
Brief Process:
DB-11 is reacted with HF 70% which yields Betamethasone and purified in organic solvent Dichloromethane and in methanol by charcoalization.
CHEMICAL REACTIONS:
A-88 33. BETAMETHASONE
DB-11 (1.0 KG)
HF 70% (1.5 KG) WATER (10.0 KG)
12.60 KG
FILTERATION Effluent (11.54 KG)
MDC (1.33 KG) SOLID CHARCOAL /HYFLOW METHANOL (4.0 KG) (6.44 KG) (005. KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.19 KG) (5.20 KG) Charcoal (0.05 KG)
A-89 Flow Chart With Mass Balance: NAME OF PRODUCT : BETAMETHASONE ACETATE QUANTITY TO BE PRODUCED : 0.2 MT/Month MAXIMUM QUANTITY : 8.487 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) BETAMETHASONE 8.15 ACETIC ANHYDRIDE 8.49 PYRIDINE 24.44 MDC 16.30 METHANOL 25.46 Charcoal/hyflow 0.42 Water 84.87
Brief Process:
Betamethasone reacts with Acetic anhydride and yields Betamethasone Acetate in presence of organic solvent MDC and pyridine which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-90 Flow Chart With Mass Balance:
34. BETAMETHASONE ACETATE
BETAMETHASONE (0.96 KG) ACETIC ANHYDRIDE (1.0 KG)
PYRIDINE (2.88kg) WATER (10.0 KG)
14.840 KG
FILTERATION ML (13.750KG)
MDC (1.92 KG) SOLID CHARCOAL/HYFLOW METHANOL (3.0 KG) (6.06 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.21 KG) (4.8 KG) Charcoal 0.05kg
A-91 NAME OF PRODUCT : BETAMETHASONE DIPROPIONATE QUANTITY TO BE PRODUCED : 0.02 MT/Month MAXIMUM QUANTITY : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) BETAMETHASONE 17 PROPIONATE 8.49 PROPIONIC ANHYDRIDE 9.52 PYRIDINE 9.12 MDC 16.97 METHANOL 42.44 Water 67.90 Charcoal / Hyflow 0.42
Brief Process:
Betamethasone 17 propionate reacts with Propionic anhydride and yields Betamethasone dipropionate in presence of organic solvent methylene chloride and pyridine which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-92 35. BETAMETHASONE DIPROPIONATE
PYRIDINE (1.075 KG) BETAMETHASONE 17 PROPIONATE (1.0 KG) PROPIONIC ANHYDRIDE (1.122 KG) WATER (8.0 KG)
11.197 KG
FILTERATION ML MEE (10.097 KG) MDC (2.00 KG) 8.15 KG
METHANOL (5 KG) CHARCOL/HYFLOW (0.05 KG)
DISTILLATION 9.26 KG
SOLID PRODUCT RECOVERD RESIDUE (1.00 KG) SOLVENT (6.85 KG) (0.25 KG) Charcoal (0.05 KG)
A-93 NAME OF PRODUCT : Betamethasone Valerate QUANTITY TO BE PRODUCED : 0.1 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Betamethasone 7.64 Tri methyl ortho valerate 6.37 PTSA 3.06 Iso Propyl Ether 53.47 Acetone 76.38 Ethyl Acetate 3.06 Sulphuric Acid 0.10 MDC 76.38 Charcoal/Hyflow 0.42 Water 76.38
Brief Process:
Betamethasone reacts with Trimethyl ortho Valerate & PTSA and yields Betamethasone
Valerate in presence of organic solvent IPE,MDC,Ethyl Acetate and H2SO4 which purified by chacoalization process in organic solvent Acetone.
CHEMICAL REACTIONS:
A-94 36. BETAMETHASONE VALERATE
TMOV (0.75 KG) BETAMETHASONE (0.9 KG) IPE (6.30 KG) MDC 9.0 KG) PTSA (0.36 KG) 17.67 KG ETHYL ACETATE (0.36 KG)
DISTILLATION ML RECOVERD SOLVENT (13.04 KG) (8.82 KG) ACETONE (9.0 KG) Solid Residue (0.1KG) 13.689 KG CHARCOL/HYFLOW Effluent (4.12 KG) H2SO4 (0.009 KG) (0.05 KG)
FILTERATION
Effluent (21.689 KG) WATER (9.0 KG) 22.689 KG
SOLID PRODUCT (1.0 KG)
A-95 NAME OF PRODUCT : Betamethasone Sodium Phosphate QUANTITY TO BE PRODUCED : 0.5 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Betamethasone Hydrogen 7.72 Phosphate Sodium Hydroxide 0.85 Methanol 39.04 Acetone 77.23 Charcoal / Hyflow 0.42
Brief Process:
Betamethasone Hydrogen Phosphate reacts with Sodium hydroxide and yields Betamethasone sodium phosphate in presence of organic solvent Methanol which purified by crystallization process in organic solvent Acetone.
CHEMICAL REACTIONS:
A-96 37. BETAMETHASONE SODIUM PHOSPHATE
BHP (0.910 KG) SODIUM HYDROXIDE (0.10 kg) KG) METHANOL (4.6 KG) CHARCOL/HYFLOW (0.05 KG) 14.760 KG ACETONE (9.1 KG)
DISTILLATION ML (13.760 KG) FILTERATION
SOLID PRODUCT RESIDUE RECOVERD 1.0 KG (0.06 KG) SOLVENT (13.70KG)
A-97 NAME OF PRODUCT : Clobetasol Propionate MAXIMUM QUANTITY TO BE : 8.467 MT/MONTH RPODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Betamethasone 17 propionate 9.51 MSC 19.01 Tri ethyl amine 4.75 Sodium bicarbonate 4.24 HCl 3.82 Dimethyl formamide 18.67 Lithium chloride 4.67 Methanol 9.34 MDC 47.19 Water 141.73
Brief Process:
Betamethasone 17 propionate will be converted into Betamethasone 17-propionate 21 sulphonate in presence of MSC,TEA sodium bicarbonate, further this compound converts into Clobetasol propionate by treating with Lithium Chloride and sulphuric acid. This crude material purified by charcoal treatment with organic solvents MDC and methanol.
CHEMICAL REACTIONS:
A-98 38. CLOBETASOL PROPIONATE
MSC (2.24 KG) MDC (3.36 KG)
Beta-17-propionate (1.12 KG) SODIUM BICARBONATE (0.5 KG)
HYDROCHLORIC ACID (0.45 KG) WATER ( KG 11.2kg)
TRIETHYL AMINE (0.56KG) 19.43 KG
EXTRACTION/DISTILLATION Effluent (14.97 KG)
ORGANIC LAYER WATER (0 KG) (4.46 KG)
DISTILLATION MDC MEE (3.36kg) DMF (2.2 KG) 5.772 KG) KGGGkkk
LiCl2 (0.55 KG) (9.35 KG)kkkkkkkgf hkkkkKG WATER (5.5 KG)
FILTERATION STRIPPER METHANOL (1.1 KG) ML (8.25 KG)
CRUDE MDC (2.2 KG) (4.4 KG) Effluent DMF +Residue (5.8 KG) (2.16 KG, 0.29) MDC (2.16 KG) DISTILLATION METHANOL MEE (1.08 KG) Residue-0.16 SOLID PRODUCT (1.0 KG)
A-99 --1 : CLOBETASOL BUTYRATE NAME OF PRODUCT MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Betamethasone 8.91 Trimethyl ortho butyrate 4.46 PTSA 0.44 MSC 4.50 Lithium Chloride 4.50 MDC 80.20 DMF 26.73 Ethyl Acetate 0.89 Pyridine 17.82 Methanol 17.82 Acetone 17.82 water 231.70 Dil H2SO4 0.13 Charcoal/hyflow 0.42 Brief Process:
Betamethasone will be converted into Betamethasone 17-butyrate 21 sulphonate in presence of TMOV,PTSA, MSC in presence of MDC, Ethyl Acetate, Pyridine and Acetone further this compound converts into Clobetasol butyrate by treating with Lithium Chloride and sulphuric acid. This crude material purified by charcoal treatment with organic solvents MDC and methanol.
CHEMICAL REACTIONS:
A-100 39. CLOBETASONE BUTYRATE
BETAMETHASONE (1.05 KG) MDC (8.4 KG)
PTSA (0.05 KG) TEOB (0.525 KG)
ETHYL ACETATE (0.105 KG) 10.13 KG
DISTILLATION MDC ACETONE (2.10 KG) (8.4 KG)
WATER (8.4 KG) (12.245 KG)
Dil H SO (0.015 KG) 2 4 FILTERATION ML (11.125 KG) PYRIDINE (2.1 KG)
MSC (0.53 KG) (14.25 KG)
WATER (10.5 KG)
FILTERATION DMF (3.15 KG) Effluent (12.930 KG)
SOLID LiCl2 (0.53 KG) (13.4 KG)
FILTERATION WATER (8.4 KG) (12.17 KG)
MDC (1.05 KG) SOLID CHARCOAL/HYFLOW (4.43 KG) METHANOL (2.1 KG) (0.05 KG) DISTILLATION
SOLID PRODUCT RESIDUE MDC & Methanol (1.00 KG) (0.34 KG) (3.09 KG)
A-101 NAME OF PRODUCT : DEXAMETHASONE QUANTITY TO BE PRODUCED : 0.25 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) 8-DM 9.34 Dichloromethane 14.00 HF 70% 18.67 Methanol 46.68 Water 93.36 Charcoal / Hyflow 0.42
Brief Process:
8-DM is reacted with HF 70% and yields Dexamethasone which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-102 40. DEXAMETHASONE
8-DM (1.10 KG)
HF 70% (2.2 KG) WATER (11 KG)
14.3 KG
FILTERATION Effluent (13.24KG)
MDC (1.65 KG) SOLID CHARCOAL/HYFLOW METHANOL (5.5 KG) (8.26 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.06 KG) (7.15 KG) Charcoal (0.05 KG)
A-103 NAME OF PRODUCT : DEXAMETHASONE SODIUM PHOSPHATE QUANTITY TO BE PRODUCED : 1.0 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Dexamethasone Hydrogen 7.72 Phosphate Sodium Hydroxide 0.76 Methanol 39.04 IPA 77.23 Charcoal / Hyflow 0.42
Brief Process:
Dexamethasone Hydrogen Phosphate reacts with Sodium hydroxide and yields Dexamethasone sodium phosphate in presence of organic solvent Methanol which purified by crystalization process in organic solvent IPA.
CHEMICAL REACTIONS:
A-104 41. DEXAMETHASONE SODIUM PHOSPHATE
DHP (0.910 KG) SODIUM HYDROXIDE (0.09kg) KG) METHANOL (4.6 KG) CHARCOL/HYFLOW (0.05 KG) 14.750 KG IPA (9.1KG)
DISTILLATION ML (13.75KG) FILTERATION
SOLID PRODUCT RESIDUE RECOVERD 1.0 KG (0.05 KG) SOLVENT (13.70KG)
A-105 NAME OF PRODUCT : DEXAMETHASONE ACETATE QUANTITY TO BE PRODUCED : 0.025 MT/Month MAXIMUM QUANTITYT TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) DEXAMETHASONE 8.15 ACETIC ANHYDRIDE 9.00 PYRIDINE 24.44 MDC 16.30 METHANOL 24.61 Water 81.48 Charcoal / Hyflow 0.42
Brief Process:
Dexamethasone reacts with Acetic anhydride and yields Dexamethasone Acetate in presence of organic solvent pyridine which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-106 42. DEXAMETHASONE ACETATE
DEXAMETHASONE (0.96 KG) ACETIC ANHYDRIDE (1.06KG)
PYRIDINE (2.88 KG) WATER (9.6 KG)
14.50 KG
FILTERATION Effluent (13.35 KG)
MDC (1.92 KG) SOLID CHARCOAL/HYFLOW METHANOL (2.9 KG) (6.02 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.15 KG) (4.82 KG) CHARCOAL/Hyflow (0.05 KG)
A-107 NAME OF PRODUCT : DEFLAZACORT QUANTITY TO BE PRODUCED : 0.50 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) D-8 8.66 Potassium Acetate 8.49 Acetic Acid 0.42 Dimethyl Formamide 16.97 Acetone 43.28 Water 86.57 Charcoal / Hyflow 0.42
Brief Process:
D-8 reacts with Potassium acetate & Acetic acid and yields Deflazacort in presence of organic solvent Dimethyl formamide and Acetone which purified by chacoalization process in organic solvent Acetone.
CHEMICAL REACTIONS:
A-108 43. DEFLAZACORT
D-8 (1.020 KG) POTASSIUM ACETATE (1.0 KG) DMF (2.0KG) ACETIC ACID (0.05 KG) 19.37 KG ACETONE (5.1 KG) WATER (10.2 KG) DISTILLATION RECOVERD SOLVENT (7.1 KG)
Effluent (11.12 KG) FILTERATION
ACETONE (5.1 KG) 6.30 KG CHARCOL/HYFLOW (0.05 KG) DISTILLATION Solvent (5.1 KG) Charcoal (0.05 KG) Solid Residue (0.15 KG)
SOLID PRODUCT (1.00 KG)
A-109 NAME OF PRODUCT : HYDROCORTISONE QUANTITY TO BE PRODUCED : 0.05 MT/Month MAXIMUM QUANTITY TO BE : 8.487 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Hydrocortisone Acetate 9.34 Acetic Acid 4.67 Sodium Hydroxide 2.80 Dichloromethane 46.68 Methanol 65.35 Water 74.69 Charcoal / Hyflow 0.42
Brief Process:
Hydrocortisone Acetate reacts with Acetic acid and yields Hydrocortisone which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-110 44. HYDROCORTISONE
HYDROCORTISONE ACETATE (1.1 KG) ACETIC ACID (0.55 KG)
METHANOL (4.4 KG) WATER (8.8 KG)
MDC (3.3 KG) 18.48 KG NaOH (0.33 KG)
EXTRACTION ML (9.68 KG)
MDC (2.20 KG) CHARCOAL/HYFLOW METHANOL (3.30 KG) (14.35 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.37 KG) (13.2KG) CHARCOAL (0.05)
A-111 NAME OF PRODUCT : HYDRCORTISONE ACETATE QUANTITY TO BE PRODUCED : 0.2 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Hydrocortisone 8.15 Acetic Anhydride 4.07 Pyridine 16.30 Dichloromethane 16.30 Methanol 24.44 Water 81.48 Charcoal 0.42
Brief Process:
Hydrocortisone reacts with Acetic anhydride and yields Hydrocortisone Acetate in presence of organic solvent pyridine which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-112 45. HYDROCORTISONE ACETATE
HYDROCORTISONE (0.96 KG) ACETIC ANHYDRIDE (0.48 KG)
PYRIDINE (1.92 KG) WATER (9.6 KG)
12.96 KG
FILTERATION Effluent (11.870 KG)
MDC (1.92 KG) SOLID CHARCOAL/HYFLOW METHANOL (2.88 KG) (5.94 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.09 KG) (4.8 KG) CHARCOAL (0.05)
A-113 NAME OF PRODUCT : PREDNISOLONE QUANTITY TO BE PRODUCED : 0.05 MT/Month
Raw Materials Require:
Raw Materials Quantity in MT/Month P1 9.34 kg Acetic Acid 6.53 kg Sodium hydroxide 0.85 kg Dichloromethane 5.23 kg Methanol 79.35 kg Water 170.16 kg Charcoal/Hyflow 0.85 kg
Brief Process:
P1 reacts with Acetic acid and hydrolysis with sodium hydroxide and yields Prednisolone in presence of organic solvents which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-114 46. PREDNISOLONE
P1 (1.3 KG) ACETIC ACID (0.65kg) KG)
METHANOL (5.2 KG) WATER (9.1 KG)
MDC (2.6 KG) NaOH (0.40 KG) 19.25 KG
EXTRACTION ML Stripper (10.15 KG)
MDC (1.95 KG) CHARCOAL/HYFLOW (13.70KG) METHANOL (2.6 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.61 KG) (12.35 KG) Charcol 0.05kg
A-115 NAME OF PRODUCT : PREDNISOLONE ACETATE QUANTITY TO BE PRODUCED : 0.02 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Prednisolone 8.15 Acetic Anhydride 4.07 Pyridine 16.30 Dichloromethane 16.30 Methanol 24.61 Water 81.48 Charcoal/hyflow 0.42
Brief Process:
Prednisolone reacts with Acetic anhydride and yields Prednisolone Acetate in presence of organic solvent pyridine which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-116 47. PREDNISOLONE ACETATE
PREDNISOLONE (0.96 KG) ACETIC ANHYDRIDE (0.48 KG)
PYRIDINE (1.92 KG) WATER (9.6 KG)
12.96 KG
FILTERATION Effluent (11.82 KG)
MDC (1.92 KG) SOLID CHARCOAL/HYFLOW METHANOL (2.9 KG) (6.01 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.14KG) (4.82 KG) CHARCOAL/Hyflow (0.05 KG)
A-117 Flow Chart With Mass Balance:
NAME OF PRODUCT : PREDNISONE QUANTITY TO BE PRODUCED : 0.5 MT/Month
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Dihydrocortisone 21-Acetate 9.34 kg Pyridine 28.01 kg Bromine 3.73 kg Colidine 3% 18.67 kg KHCO3 9.34 kg Methanol 46.68 kg Water 93.36 kg
Carrenone 0.0550 9.34 Ethanol 0.3525 59.83 Methyl Sulphonyl Chloride 0.0308 5.23 Potassium Thioacetate 0.0385 6.53 Ethanol 0.0275 4.67 Ethanol 0.9750 165.50 Charcoal/hyflow 0.0050 0.85
Brief Process:
Dihydrocortisone 21 Acetate reacts with Pyridine, Br2 & Colidine and yields Prednisone which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-118 Flow Chart With Mass Balance:
48. PREDNISONE
Br2 (0.44 KG) PYRIDINE (3.25 KG)
DIHYDROCORTISONE 15.84 KG WATER ( 11.0 KG) 21-ACETATE (1.10 KG)
FILTERATION Effluent (14.79 KG)
COLIDINE 3% ( 2.2 KG)
METHANOL ( 5.5 KG) CHARCOL/HYFLOW 9.90 KG (0.05 KG) KHCO3 (1.10 KG)
DISTILLATION
SOLID PRODUCT 1.0 KG RESIDUE RECOVERED SOLVENT (0.1 KG) (8.75 KG) Charcoal 0.05kg
A-119 NAME OF PRODUCT : PREDNISOLONE SODIUM PHOSPHATE QUANTITY TO BE PRODUCED : 0.1 MT/Month MAXIMUM QUANTITY : 8.467 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Prednisolone 7.72 Pyro phosphoril chloride 11.58 Tetra hydro furon 46.68 Methanol 30.53 Acetone 84.87 Sodium hydroxide 1.70 Water 77.23 Charcoal / Hyflow 0.42
Brief Process:
Prednisolone reacts with Pyrophosphoryl chloride & THF which convert to Prednisolone hydrogen phosphate then react with sodium hydroxide and yields Prednisolone sodium phosphate in presence of organic solvent Methanol which purified by crystallization process in organic solvent acetone.
CHEMICAL REACTIONS:
A-120 49. PREDNISOLONE SODIUM PHOSPHATE
PYRO PHOSPHORYL CHLORIDE PREDNISOLONE (0.910 KG) (1.365 KG) THF (5.5 KG)
NaOH (0.20 KG) 17.075 KG WATER (9.1 KG)
FILTERATION/DISTILLATION THF (5.5 KG)
Effluent (10.495 KG)
METHANOL (3.6 KG) CHARCOL/HYFLOW 14.73 KG (0.05 KG) ACETONE (10.0 KG)
FILTERATION/DISTILLATION
SOLID PRODUCT 1.0 KG RESIDUE RECOVERED SOLVENT Hyflow (0.42 KG) (13.6 KG) (0.05 KG)
A-121 +NAME OF PRODUCT : Mometasone Furoate MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) 8 DM 8.49 Dichloromethane 169.74 DMAP 3.82 PTSC 8.49 Water 178.23 TEA 3.39 Hydrochloric Acid 2.55 2 FC 4.41 Sodium bicarbonate 12.73 Acetic Acid 25.46 Charcoal/hyflow 0.42
Brief Process:
8-DM reacted with DMAP,PTSC,Hcl,2FC,TEA and Acetic acid chlorination with Hydrochloric acid and yields Mometasone Furoate which purified by chacoalization process in organic solvent MDC.
CHEMICAL REACTIONS:
A-122 51. MOMETASONE FUROATE
8-DM (1.0 KG) MDC (10.0 KG)
PTSC (1.0 KG) DMAP (0.450 KG)
12.45 KG
TEA (0.40 KG) HCl (0.3 KG)
2-FC (0.520 KG) (26.17 KG) WATER (11.0 KG)
NaHCO (1.50 KG) 3 EXTRACTION Effluent (14.17 KG)
ORGANIC LAYER (12.00 KG)
DISTILLATION MDC (10 KG) MDC (10 KG)
SOLID HCl (0.30 KG) ACETIC ACID (3.0 KG) (25.3 KG)
EXTRACTION WATER (10.0 KG) Aq. ML (14 KG)
(12.05 KG) CHARCOAL/HYFLOW (0.05 KG) DISTILLATION
SOLID PRODUCT RESIDUE RECOVERED SOLVENT (1.00 KG) (0.45 KG) (9.80 KG) Charcoal (0.05 KG)
A-123 NAME OF PRODUCT : DUTASTERIDE QUANTITY TO BE PRODUCED : 0.03 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) M-4 Acid 8.49 2-5 bis Trifluro aniline 5.09 MDC 63.65 Methanol 42.44 IPE 38.19 Pyridine 2.55 Chloroform 64.50 Water 0 Charcoal / Hyflow 0.34
Brief Process:
M-4 acid is reacted with 2-5 Bis Trifluro aniline in presence of Pyridine and MDC and yealds Dutasteride which purified by organic solvent chloroform,IPE and Methanol.
CHEMICAL REACTIONS:
A-124 52. DUTASTERIDE
M-4 ACID (1.0 KG) MDC (7.50 KG)
PYRIDINE (0.30 KG) 2-5 bis trifluro aneline (0.40 KG)
Water (0 KG) 9.20 KG
DISTILLATION
RESIDUE Effluent (0.15 KG) (7.8 KG)
CHLOROFORM (7.60 KG) SOLID IPE (4.50 KG) (13.35 KG)
DISTILLATION
METHANOL (5.0 KG) SOLID (6.29 KG) CHARCOAL/HYFLOW RESIDUE RECOVERED SOLVENT (0.04 KG) (0 KG) (12.10 KG) DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT CHARCOAL/HYFLOW (0.290 KG) (5.0 KG) (0.04 KG)
A-125 NAME OF PRODUCT : HALOBETASOL PROPIONATE QUANTITY TO BE PRODUCED : 0.02 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Halobetasol 17-Propionate 9.51 Methyl sulphonyl chloride 14.43 Triethyl amine 5.94 Dimethyl Formamide 14.43 Lithium chloride 4.75 Hydrochloric Acid 3.82 Sodium bicarbonate 4.24 Methanol 14.43 Dichloromethane 42.94 Water 169.74 Brief Process:
Halobetasol 17 propionate will be converted into Halobetasol 17-propionate 21 sulphonate in presence of MSC,TEA sodium bicarbonate, further this compound converts into Halobetasol propionate by treating with Lithium Chloride. This crude material purified by charcoal treatment with organic solvents MDC and methanol.
CHEMICAL REACTIONS:
A-126 HALOBETASOL PROPIONATE
MSC (1.70 KG) MDC (4.5 KG)
Halo-17-propionate (1.12 KG) SODIUM BICARBONATE (0.5 KG)
HYDROCHLORIC ACID (0.45 KG) WATER (11 KG)
TRIETHYL AMINE (0.7 KG) 19.97 KG
EXTRACTION/DISTILLATION ML (14.35 KG)
ORGANIC LAYER WATER (0 KG) (5.62 KG) DISTILLATION
DMF (1.7 KG) MDC (4.5 KG)
LiCl2 (0.56 KG) (12.38 KG) WATER Solvent WATER (9.0 KG) (11.0 KG) (3.35 KG)
FILTERATION STRIPPER METHANOL (1.7 KG) ML (11.28 KG)
CRUDE MDC (0.56 KG) (3.36 KG) DMF+ Residue WATER 2.28 kg (9.0 KG)
MDC (0.56 KG) DISTILLATION METHANOL MEE (1.7 KG) Residue-0.1 SOLID PRODUCT (1.0 KG)
A-127 NAME OF PRODUCT : FLUOCINOLONE ACETONIDE QUANTITY TO BE PRODUCED : 0.025 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Fluocinolone 8.49 Perchloric Acid 0.42 Sodium bicarbonate 1.27 Dimethyl Formamide 12.73 Acetone 16.97 Water 25.46 Charcoal/Hyflow 0.42
Brief Process:
Fluocinolone is reacted with Perchloric acid and Sodium bicarbonate which yields Fluocinolone Acetonide and purified in Dimethyl Formamide.
CHEMICAL REACTIONS:
A-128 54. FLUOCINOLONE ACETONIDE
FLUOCINOLONE (1.0 KG) PERCHLORIC ACID (0.05 KG) ACETONE (2.0 KG) SODIUM BICARBONATE (0.15 KG) 3.70 KG WATER (0.50 KG)
ML (2.65 KG) FILTERATION
STRIPPER WATER 1.18 KG DMF (1.5 KG) CRUDE 5.60 KG WATER (3.0 KG) SOLVENT (1.47 KG) CHARCOAL/HYFLOW (0.05 KG) FILTERATION CHARCOL/HYFLOW (0.05 KG)
SOLID PRODUCT Aq.ML (1.00 KG) (4.55 KG)
A-129 NAME OF PRODUCT : FLUOCINONIDE QUANTITY TO BE PRODUCED : 0.025 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Fluocinolone Acetonide 8.15 Acetic Anhydride 4.24 Pyridine 24.44 MDC 16.30 Methanol 24.61 Water 81.48 Charcoal/Hyflow 0.42
Brief Process:
Fluocinolone acetonide is reacted with Acetic anhydride in presence of pyridine and purified by charcoalization in oraganic solvent MDC and Methanol.
CHEMICAL REACTIONS:
A-130 55. FLUOCINONIDE
FLUOCINOLONE ACETONIDE (0.96 KG) ACETIC ANHYDRIDE (0.5 KG)
PYRIDINE (2.88 KG) WATER (9.6 KG)
13.94 KG
FILTERATION Effluent (12.850KG)
MDC (1.92KG) CHARCOAL/HYFLOW SOLID (0.05 KG) METHANOL (2.90 KG) (5.96 KG)
DISTILLATION 6.80 kg
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED CHARCOAL/HYF (0.09 KG) SOLVENT LOW (4.82 KG) (0.05 KG)
A-131 NAME OF PRODUCT : TRIAMCINOLONE QUANTITY TO BE PRODUCED : 0.05 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) DMF 3.39 NH4OH 80.63 Water 93.36 STR 8.49 HF 27.16 MDC 50.92 Methanol 33.95 Charcoal / Hyflow 0.42
Brief Process:
5TR reacted with HF in presence of Dimethyl formamide it which is neutralized with ammonium hydroxide and yields Triamcinolone which is purified in organic solvent Dichloromethane and methanol.
CHEMICAL REACTIONS:
A-132 56. TRIAMCINOLONE
STR (1.0 KG) DMF (0.40 KG) HF 70%(3.2 KG)
NH4OH (9.5 KG) 25.1 KG WATER (11.0 KG)
ML (23.9KG) FILTERATION
MDC (6.0 KG) CRUDE 1.2 KG METHANOL (4.0KG) CHARCOL/HYFLOW (0.05 KG) FILTERATION CHARCOL/HYFLOW (0.05 KG) RECOVERED SOLVENT (10.00 KG) Solid Residue (0.40 KG)
SOLID PRODUCT (1.00 KG)
A-133 NAME OF PRODUCT : TRIAMCINOLONE ACETONIDE QUANTITY TO BE PRODUCED : 0.1 MT/Month MAXIMUM QUANTITY TO BE : 8.487 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Triamcinolone 8.4870 Perchloric Acid 0.4244 Triethyl Amine 3.3948 Dichloromethane 50.9220 Methanol 21.2175 Water 59.4090 Acetone 63.6525 Charcoal / Hyflow 0.3395
Brief Process:
Triamcinolones react with Perchloric acid and Triethyl amine which converts into Triamcinolone acetonide & finally purified with organic solvent dichloromethane and methanol.
CHEMICAL REACTIONS:
A-134 57. TRIAMCINOLONE ACETONIDE
TRIETHYL AMINE (0.40 KG) TRIAMCINOLONE (1.0 KG) ACETONE (7.5 KG) PERCHLORIC ACID (0.05 KG)
8.95 KG
DISTILLATION RECOVERD SOLVENT (7.5 KG) WATER (7.0 KG) 8.45KG
FILTERATION Effluent (7.0 KG)
MDC (6.0 KG) CRUDE PRODUCT METHANOL (2.5 KG) 9.99 KG
CHARCOL/HYFLOW (0.04 KG)
DISTILLATION/FILTERATION
SOLID PRODUCT (1.0 KG) Solvent SOLID (8.95 KG) (0.72KG) Charcoal (0.04 kg)
A-135 NAME OF PRODUCT : TRIAMCINOLONE HEXACETONIDE QUANTITY TO BE PRODUCED : 0.01 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum)
Pyridine 18.67 Triamcinolone Acetonide 9.34 3,3, Dimethylbutyl Chloride 7.47 Water 102.69 MDC 74.69 Charcoal / Hyflow 0.51 Methanol 61.11
Brief Process:
Triamcinolone is reacted with 3,3-Dimethyl butyl chloride & Pyridine and yields Triamcinolone hexacetonide, crude material is purified with charcoal treatment in organic solvent Dichloromethane and methanol.
CHEMICAL REACTIONS:
A-136 58. TRIAMCINOLONE HEXAACETONIDE
TRIAMCINOLONE ACETONIDE (1.1 KG) PYRIDINE (2.2 KG) 3,3,DIMETHYLBUTYLYL CHLORIDE(0.88 KG)
16.28KG WATER (12.1 KG)
Effluent (15.03 KG) FILTERATION
MDC (8.8 KG) CRUDE 17.31 KG METHANOL (7.2 KG) CHARCOL/HYFLOW (0.06 KG) DISTILLATION CHARCOL/HYFLOW (0.06 KG)
SOLID PRODUCT RECOVERED SOLVENT (1.00 KG) (16.0 KG) Solid Residue (0.58 KG)
A-137 NAME OF PRODUCT : DIFLUPREDNATE QUANTITY TO BE PRODUCED : 0.10 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (MAXIMUM) Diflexone 17-pentate 9.76 TEA 3.82 MDC 58.56 Acetic Anhydride 11.71 Ethyl Acetate 21.47 IPE 17.57 Water 67.90 Charcoal 0.42
Brief Process:
Diflexone 17-pentate is reacted with Acetic anhydride in presence of Triethyl amine and Triethyl amine then purified by organic solvent as Ethyl acetate and IPE.
CHEMICAL REACTIONS:
A-138 59. DIFLUPREDNATE
DIFLXASONE-17-PENTATE (1.15 KG) TEA (0.45 KG) MDC(6.9 KG) ACETIC ANHYDRIDE (1.38 KG) 17.88 KG WATER (8.0 KG)
Effluent (9.83 KG) EXTRACTION
ETHYL ACETATE (2.53 KG) ORGANIC LAYER 12.7 KG IPE (2.07 KG) CHARCOL (0.05 KG)
FILTERATION SOLID Charcoal/ Hyflow DISTILLATION (0.35 KG) (0.05 KG)
SOLID PRODUCT RECOVERED SOLVENT (1.00 KG) (11.5 KG)
A-139 NAME OF PRODUCT : METHYLPREDNISOLONE QUANTITY TO BE PRODUCED : 2.0 MT/Month MAXIMUM QUANTITY TO : 8.467 MT/Month BEPRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) P1 10.18 Acetic Acid 6.11 Methanol 30.55 Dichloromethane 35.65 Water 101.84 Charcoal / Hyflow 0.42
Brief Process:
Methylprednisolone Acetate reacts with Acetic acid and yields Methylprednisolone which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-140 60. METHYLPREDNISOLONE
P1 ACETIC ACID (0.72 KG) (1.20 KG)
WATER (12.0 KG) METHANOL (3.6 KG) MDC (1.8 KG) 19.32 KG
EXTRACTION EFFLUENT 18.236 KG
MDC (2.4 KG) SOLID METHANOL (6.0 KG) (9.534 KG)
CHARCOAL/HYFLOW (0.05 KG) DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.084KG) (8.40 KG) Charcoal -0.05 KG
A-141 NAME OF PRODUCT : METHYLPREDNISOLONE ACETATE QUANTITY TO BE PRODUCED : 0.05 MT/Month MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Methylprednisolone 8.15 Acetic Anhydride 4.24 Pyridine 20.37 Dichloromethane 16.30 Methanol 28.52 Water 89.96 Charcoal / Hyflow 0.42
Brief Process:
Methylprednisolone reacts with Acetic anhydride and yields Methylprednisolone Acetate in presence of organic solvent pyridine which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-142 61. METHYLPREDNISOLONE ACETATE
METHYLPREDNISOLONE (0.96 KG) ACETIC ANHYDRIDE (0.5 KG)
PYRIDINE (2.40 KG) WATER (10.6 KG)
14.46 KG
FILTERATION EFFLUENT (13.37 KG)
MDC (1.92 KG) SOLID CHARCOAL/HYFLOW METHANOL (3.36KG) (6.42 KG) (0.05 KG)
DISTILLATION
SOLID PRODUCT (1.0 KG) RESIDUE RECOVERED SOLVENT (0.09 KG) (5.28 KG) CHARCOAL (0.05 KG)
A-143 NAME OF PRODUCT : FLUTICASONE PROPIONATE MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED Raw Materials Require: Raw Materials Fluticasone 10.61 Sodium metaperiodate 16.30 Tetra hydro Furan 53.04 Methanol 28.52 Dimethyl formamide 33.95 Bromochloromethane 6.37 Triethyl amine 8.49 Diamidaol 6.37 Diethyl Acetamide 42.44 MSC 6.11 Acetone 84.87 Sodium Iodide 2.12 Silver fluoride 1.06 Acetonitrile 135.79 Chloroform 21.22 water 445.57 Charcoal/hyflow 0.64 Brief Process:
Fluticasone will be converted into Fluticasone 17-propionate 21 sulphonate by reaction
Diamidiol,Bromochloromethane,THF, MSC,TEA & NaIO4 , further this compound converts into
Fluticasone propionate by treating with CH2BrCl and AgF I presence of Acetonitrile. This crude material purified by charcoal treatment with organic solvents Chloroform and methanol.
CHEMICAL REACTIONS:
A-144 62. FLUTICASONE PROPIONATE
FLUMETHASONE (1.25 KG) SODIUM META PER IODATE (1.375 KG)
THF (6.25 KG) WATER (10.0 KG)
METHANOL (2.5 KG) 21.375 KG
FILTERATION/ DISTILLATION DMF (4.0 KG)
WATER (12.5 KG) (18.30 KG) Effluent SOLVENT DIIMIDAOLE (0.75 KG) (11.745 KG) (THF -6.13 KG) BROMOCHLOROMETHANE (0.75 KG) DISTILLATION Methanol-2.45 DIMETHYL ACETAMIDE (5.0 KG) TEA (1.00 KG) (15.30 KG) Effluent DMF WATER (7.5 KG) (13.25 KG) (4.00 KG)
FILTERATION Effluent ACETONE (10.0 KG) (14.25 KG)
Na I (0.250 KG) SOLID 7. (21.30 KG)
WATER (10.0 KG) DISTILLATION
SILVER FLUORIDE (0.125 KG) SOLID WATER (12.5 KG) (29.67 KG) ACETONITRILE (16.0 KG) Effluent ACETONE DISTILLATION (10.25 KG) (10.0 KG)
CHLOROFORM (2.5 KG) SOLID Effluent ACETONITRILE METHANOL (5.0 KG) (8.625 KG) (12.625) (16.0kg)
CHARCOAL/HYFLOW DISTILLATION (0.075 KG) SOLID PRODUCT (1.0 KG) RESIDUE MIX SOLVENT (0.125KG) (7.5 KG)
A-145 NAME OF PRODUCT : FLUOROMETHOLONE MAXIMUM QUANTITY TO BE : 8.487 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) 17α-hydroxy-6α –metyl-9(11)β- 8.49 epoxy-1,4-pregnadine-3,20-dione HF 70% 10.18 Ammonium hydroxide 1.70 MDC 54.32 Methanol 32.35 Water 106.09 Charcoal/hyflow 0.34
Brief Process:
17α-hydroxy-6α –metyl-9(11)β-epoxy-1,4-pregnadine-3,20-dione is reacted with HF 70% and neutralized with ammonium hydroxide and purified by charcoalization in oraganic solvent MDC and Methanol.
CHEMICAL REACTIONS:
A-146 63. FLUOROMETHOLONE
17α-hydroxy-6α –metyl-9(11)β-epoxy-1,4- pregnadine-3,20-dione (1.0 KG)
HF 70% (1.2 KG)
NH4OH (0.20 KG) 14.9 KG WATER (12.5 KG)
Effluent (13.8 KG) FILTERATION
MDC (6.4 KG) CRUDE 11.34 KG METHANOL (3.8 KG) CHARCOL/HYFLOW (0.04 KG) Distillation CHARCOL/HYFLOW (0.04 KG) RECOVERED SOLVENT (9.996 KG) Solid Residue (0.304 KG)
SOLID PRODUCT (1.00 KG)
A-147 NAME OF PRODUCT : LOTEPREDNOL ETHABONATE MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Prednisolone 9.34 Periodic Acid 9.34 Tetra hydro furan 46.68 Chloromethyl iodide 4.67 Ethyl chloroformate 51.35 Acetone 56.01 water 280.07 Charcoal/Hyflow 0.51
Brief Process:
Prednisolone is reacted with Periodic acid ,THF ,Chloromethyl iodide & ethyl chloroformate and yields Loteprednol Ethabonate, crude material is purified with charcoal treatment in organic solvent Acetone.
CHEMICAL REACTIONS:
A-148 64. LOTEPREDNOL ETABONATE
PER IODIC ACID (1.1 KG) PREDNISOLONE (1.10 KG) WATER (12.1 KG) THF (5.5 KG) 19.80 KG
WATER (9.9 KG) FILTERATION/ DISTILLATION
CHLORO METHYL IOIODIDE (0.55 KG) 17.62 KG
ETHYL CHLOROFORMATE (6.05 KG) Effluent THF (13.29 KG) (5.39 KG)
DISTILLATION
ACETONE (6.6 KG)
SOLID Effluent ETHYL WATER (11.0 KG) (18.71 KG) (10.57 KG) CHLOROFORMATE (6.0 KG) CHARCOL/HYFLOW (0.06 KG) FILTERATION
SOLID PRODUCT (1.00 KG) RESIDUE Effluent Solvent (0.05 KG) (11.0 KG) (6.6 KG)
A-149 NAME OF PRODUCT : DIFLUCORTILONE VALERATE MAXIMUM QUANTITY TO BE : 8.467 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Flumethasone 8.49 Sodium Thiosulphate 0.85 TMSI 7.64 Pyridine 16.97 Valeric Anhydride 8.49 Methanol 42.44 Dichloromethane 89.95 Water 135.79 IPA 0.85 Charcoal / Hyflow 0.42
Brief Process:
Flumethasone reacts with Valeric anhydride & TMSI and yields Betamethasone Valerate in presence of organic solvent Pyridine,MDC which purified by chacoalization process in organic solvent methanol.
CHEMICAL REACTIONS:
A-150 65. DIFLUCORTILONE VALERATE
MDC (9.0 KG) FLUMETHASONE (1.0 KG) SODIUM THIOSULPHATE(0.10 KG) WATER (8.0 KG) TMSI (0.90 KG) 19.1 KG IPA (0.10 KG)
EXTRACTION/DISTILLATION 18 KG
PYRIDINE (2.0 KG) 1.10 KG WATER (8.0 KG)
VALERIC ANHYDRIDE (1.0 KG) Effluent MDC (9.18 KG) (8.82 KG)
EXTRACTION/DISTILLATION
MDC (1.6 KG)
SOLID PYRIDINE Effluent METHANOL (5.0 KG) (1.05 KG) (2.0 KG) (9.05 KG)
CHARCOL/HYFLOW (0.05 KG) DISTILLATION 6.7 KG
SOLID PRODUCT (1.00 KG) Charcoal SOLVENT (0.05 KG) (6.65 KG)
A-151 NAME OF PRODUCT : DESOXIMETHASONE MAXIMUM QUANTITY : 8.487 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Dexamethasone 9.34 Dichloromethane 18.67 Acetonitrile 74.69 Methanol 46.68 Water 84.87 TMSI 11.20 Charcoal / Hyflow 0.42
Brief Process:
Dexamethasone is reacted with TMSI and Acetic acid and yields Desoximethasone which purified by chacoalization process in organic solvent MDC and methanol.
CHEMICAL REACTIONS:
A-152 66. DESOXIMETHASONE
ACETONITRILE (8.8 KG) DEXAMETHASONE (1.1 KG)
WATER (10.0 KG) TMSI (1.320 KG) 21.22 KG
EXTRACTION/DISTILLATION
CHARCOL/HYFLOW MDC (2.2 KG) 9.27 KG (0.05 KG)
METHANOL (5.5 KG) Effluent (10.9 KG) ACN (8.8 KG)
DISTILLATION
MDC METHANOL (2.2 KG) (5.5 KG)
SOLID PRODUCT (1.00 KG) RESIDUE (0.570 KG)
A-153 NAME OF PRODUCT : EPLERENONE MAXIMUM QUANTITY TO BE : 8.487 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month dienyl methyl ester 12.31 Trichloroacetamide 8.00 Sodium acetate 7.38 Dichloromethane 147.67 30% H2O2 49.22 Sodium hydrogen sulphite Potable water Sodium Hydroxide 0.37 Potable water Hydrochloric acid 1.23 Potable water 24.61 Sodium chloride Butanone Ethy Acetate 172.29 Brief Process:
Dienyl methyl esteris reacted with 30% hydrogen peroxide in presence of sodium acetate and sodium bisulfite and trichloroacetamide in methylene chloride and yields eplerenone crude. This crude material is purified in organic solvent.
CHEMICAL REACTIONS:
A-154 67. EPLERENONE
DIENYL METHYL ESTER (1.45 KG)
SODIUM ACETATE(0.87KG) TRICHLOROCETAMIDE (0.943 KG)
H2O2 30% (5.8 KG) DI CHLORO METHANE (17.40 KG)
26.463 KG
HYDROCHLORIC ACID (0.145KG) EXTRACTION Effluent SODIUMHYDROXIDE (0.0435 kg) 21.9385 KG (7.613KG) ORGANIC LAYER WATER (2.9 KG)
EXTRACTION DISTILLATION
ETHYL ACETATE CRUDE Effluent (20.885 KG) (20.3 KG) (21.3535 KG)
DISTILATION
PRODUCT (1.0 KG)
SOLVENT (19.90 SOLID RESIDUE (0.45 KG) KG)
A-155 NAME OF PRODUCT : SPIRONOLACTONE MAXIMUM QUANTITY TO BE : 8.487 MT/Month PRODUCED
Raw Materials Require:
Raw Materials Quantity in MT/Month (Maximum) Carrenone 9.34 Ethanol 51.35 Methyl Sulphonyl Chloride 4.67 Potassium thioacetate 5.60 Ethanol / methanol 107.36 Potable water Charcoal/hyflow 0.51
Brief Process:
Canrenone is reacted with potassium thioacetate and methanesulfonyl chloride which yields spironolactone and purified in ethanol or methanol by charcoalization.
CHEMICAL REACTIONS:
A-156 68. SPIRONOLACTONE
METHYL SULPHONYL CHLORIDE (0.55 KG) (1.45 KG) CARRENONE (1.1 KG) POTASSIUM THIOACETATE (0.66 KG)
ETHANOL (6.05 KG)
8.36 KG
DISTILLATION SOLVENT (3.36 KG) ETHANOL (0.55 KG) 5.55 KG ORGANIC LAYER
FILTERATION
ETHANOL (12.1 KG) CRUDE PRODUCT (13.21 KG) EFFLUENT (4.5 KG) CHARCOL/HYFLOW (0.06 KG) FILTERATION
SOLID PRODUCT (1.0 KG)
SOLVENT -12.0 KG CHARCOAL/ Hyflow-0.06 kg Residue – 0.15 kg
A-157