Barriers to Clinical Trial Enrollment in Racial and Ethnic Minority Patients with Cancer
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cancercontroljournal.org Vol. 23, No. 4, October 2016 H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, AN NCI COMPREHENSIVE CANCER CENTER Barriers to Clinical Trial Enrollment in Racial and Ethnic Minority Patients With Cancer Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer Black Heterogeneity in Cancer Mortality: US-Blacks, Haitians, and Jamaicans Genomic Disparities in Breast Cancer Among Latinas Clinical Considerations of Risk, Incidence, and Outcomes of Breast Cancer in Sexual Minorities Construction and Validation of a Multi-Institutional Tissue Microarray of Invasive Ductal Carcinoma From Racially and Ethnically Diverse Populations Determinants of Treatment Delays Among Underserved Hispanics With Lung and Head and Neck Cancers Geographical Factors Associated With Health Disparities in Prostate Cancer Disparities in Penile Cancer Chemoprevention in African American Men With Prostate Cancer Disparities in Adolescents and Young Adults With Cancer Tobacco-Related Health Disparities Across the Cancer Care Continuum Cancer Control is included in Index Medicus/MEDLINE Editorial Board Members Editor: Conor C. Lynch, PhD Production Team: Assistant Member Lodovico Balducci, MD Veronica Nemeth Tumor Biology Senior Member Editorial Coordinator Program Leader, Senior Adult Oncology Program Kristen J. Otto, MD Sherri Damlo Moffitt Cancer Center Associate Member Medical Copy Editor Head and Neck and Endocrine Oncology Diane McEnaney Deputy Editor: Graphic Design Consultant Julio M. Pow-Sang, MD Michael A. Poch, MD Senior Member Assistant Member Associate Editor of Chair, Department of Genitourinary Oncology Genitourinary Oncology Educational Projects Director of Moffitt Robotics Program Jeffery S. Russell, MD, PhD John M. York, PharmD Moffitt Cancer Center Assistant Member Akita Biomedical Consulting Endocrine Tumor Oncology 1111 Bailey Drive Editor Emeritus: Elizabeth M. Sagatys, MD Paso Robles, CA 93446 John Horton, MB, ChB Assistant Member Phone: 805-238-2485 Professor Emeritus of Medicine & Oncology Pathology - Clinical Fax: 949-203-6115 Saïd M. Sebti, PhD E-mail: [email protected] Moffitt Cancer Center Senior Member Journal Advisory Committee: Drug Discovery For Consumer and Daniel A. Anaya, MD Bijal D. Shah, MD General Advertising Associate Member Assistant Member Information: Gastrointestinal Oncology Malignant Hematology Veronica Nemeth Aliyah Baluch, MD Lubomir Sokol, MD, PhD Editorial Coordinator Assistant Member Senior Member Cancer Control: Journal of the Moffitt Cancer Center Infectious Diseases Hematology/Oncology Dung-Tsa Chen, PhD 12902 Magnolia Drive – MBC-JRNL Hatem H. Soliman, MD Associate Member Tampa, FL 33612 Assistant Member Biostatistics Phone: 813-745-1348 Breast Oncology Fax: 813-449-8680 Hey Sook Chon, MD E-mail: [email protected] Assistant Member Jonathan R. Strosberg, MD Gynecological Oncology Assistant Member Gastrointestinal Oncology Jasreman Dhillon, MD Assistant Member Jennifer Swank, PharmD Pathology - Anatomic Clinical Pharmacist - Medical Oncology/Internal Medicine Jennifer S. Drukteinis, MD Associate Member Sarah W. Thirlwell, MSc, MSc(A), RN Diagnostic Radiology Nurse Director Clement K. Gwede, PhD, RN Supportive Care Medicine Program Associate Member Eric M. Toloza, MD, PhD Health Outcomes and Behavior Assistant Member Sarah E. Hoffe, MD Thoracic Oncology Associate Member Nam D. Tran, MD Radiation Oncology Assistant Member John V. Kiluk, MD Neuro-Oncology Associate Member Jonathan S. Zager, MD Breast Oncology Senior Member Cancer Control is a member of Richard D. Kim, MD Cutaneous Oncology the Medscape Publishers’ Circle®, Associate Member an alliance of leading medical Gastrointestinal Oncology publishers whose content is Bela Kis, MD, PhD featured on Medscape Assistant Member (www.medscape.com). Diagnostic Radiology Rami Komrokji, MD Most issues and supplements of Associate Member Cancer Control are available at Malignant Hematology cancercontroljournal.org CANCER CONTROL: JOURNAL OF THE MOFFITT CANCER CENTER (ISSN 1073-2748) is published by H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612. Telephone: 813-745-1348. Fax: 813-449-8680. E-mail: [email protected]. Internet address: cancercontroljournal.org. Cancer Control is included in Index Medicus ®/MEDLINE® and EMBASE®/ Excerpta Medica, Thomson Reuters Science Citation Index Expanded (SciSearch®) and Journal Citation Reports/Science Edition. Copyright 2016 by H. Lee Moffitt Cancer Center & Research Institute. All rights reserved. Cancer Control: Journal of the Moffitt Cancer Center is a peer-reviewed journal that is published to enhance the knowledge needed by professionals in oncology to help them minimize the impact of human malignancy. Each issue emphasizes a specific theme relating to the detection or management of cancer. The objectives of Cancer Control are to define the current state of cancer care, to integrate recently generated information with historical practice patterns, and to enlighten readers through critical reviews, commentaries, and analyses of recent research studies. DISCLAIMER: All articles published in this journal, including editorials and letters, represent the opinions of the author(s) and do not necessarily reflect the opinions of the editorial board, the H. Lee Moffitt Cancer Center & Research Institute, Inc, or the institutions with which the authors are affiliated unless clearly specified. The reader is advised to independently verify the effective- ness of all methods of treatment and the accuracy of all drug names, dosages, and schedules. Dosages and methods of administration of pharmaceutical products may not be those listed in the package insert and solely reflect the experience of the author(s) and/or clinical investigator(s). Table of Contents Letter From the Editor Better Cancer Treatment for All 322 Lodovico Balducci, MD Editorial Highlighting Health Disparities in Racial and Ethnic Minorities and Other Underserved Populations 323 Clement K. Gwede, PhD, RN, Gwendolyn P. Quinn, PhD, and B. Lee Green, PhD Articles Barriers to Clinical Trial Enrollment in Racial and Ethnic Minority Patients 327 With Cancer Lauren M. Hamel, PhD, Louis A. Penner, PhD, Terrance L. Albrecht, PhD, Elisabeth Heath, MD, Clement K. Gwede, PhD, RN, and Susan Eggly, PhD Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer 338 Matthew B. Schabath, PhD, W. Douglas Cress, PhD, and Teresita Muñoz-Antonia, PhD Black Heterogeneity in Cancer Mortality: US-Blacks, Haitians, and Jamaicans 347 Paulo S. Pinheiro, MD, PhD, Karen E. Callahan, MPH, Camille Ragin, PhD, MPH, Robert W. Hage, MD, PhD, DLO, MBA, Tara Hylton, MPH, and Erin N. Kobetz, PhD, MPH Genomic Disparities in Breast Cancer Among Latinas 359 Filipa Lynce, MD, Kristi D. Graves, PhD, Lina Jandorf, MA, Charité Ricker, MS, Eida Castro, PsyD, Laura Moreno, Bianca Augusto, Laura Fejerman, PhD, and Susan T. Vadaparampil, PhD Clinical Considerations of Risk, Incidence, and Outcomes of Breast Cancer 373 in Sexual Minorities Anne E. Mattingly, MD, John V. Kiluk, MD, and M. Catherine Lee, MD Construction and Validation of a Multi-Institutional Tissue Microarray of 383 Invasive Ductal Carcinoma From Racially and Ethnically Diverse Populations Edward Seijo, MS, Diana Lima, MPH, Egiebade Iriabho, MS, Jonas Almeida, PhD, Jesus Monico, MPH, MS, Margarita Echeverri, PhD, Sylvia Gutierrez, MD, Idhaliz Flores, PhD, Ji-Hyun Lee, PhD, Kate Fisher, MA, William E. Grizzle, MD, PhD, Gabriel L. Sica, MD, PhD, Charles Butler, Chindo Hicks, PhD, Cathy D. Meade, PhD, RN, Stephen Olufemi Sodeke, Krzysztof Moroz, MD, Domenico Coppola, MD, and Teresita Muñoz-Antonia, PhD October 2016, Vol. 23, No. 4 Cancer Control 319 Table of Contents Articles, continued Determinants of Treatment Delays Among Underserved Hispanics With Lung and 390 Head and Neck Cancers Evelinn A. Borrayo, PhD, Katie L. Scott, PhD, Ava R. Drennen, PhD, Tiare MacDonald, PhD, and Jennifer Nguyen, MS Geographical Factors Associated With Health Disparities in Prostate Cancer 401 Scott M. Gilbert, MD, Julio M. Pow-Sang, MD, and Hong Xiao, PhD Disparities in Penile Cancer 409 Pranav Sharma, MD, Kamran Zargar-Shoshtari, MD, Curtis A. Pettaway, MD, Matthew B. Schabath, PhD, Anna R. Giuliano, PhD, and Philippe E. Spiess, MD Chemoprevention in African American Men With Prostate Cancer 415 Nagi B. Kumar, PhD, RD, Julio M. Pow-Sang, MD, Philippe E. Spiess, MD, Jong Y. Park, PhD, Ganna Chornokur, PhD, Andrew R. Leone, MD, and Catherine M. Phelan, PhD, MD Disparities in Adolescents and Young Adults With Cancer 424 Leidy L. Isenalumhe, MD, Olivia Fridgen, MPH, Lynda K. Beaupin, MD, Gwendolyn P. Quinn, PhD, and Damon R. Reed, MD Tobacco-Related Health Disparities Across the Cancer Care Continuum 434 Vani Nath Simmons, PhD, Bárbara Piñeiro, PhD, Monica Webb Hooper, PhD, Jhanelle E. Gray, MD, and Thomas H. Brandon, PhD Departments Case Series: Human Metapneumovirus Infection in Immunocompromised Patients 442 Sharmeen Samuel, MD, Sowmya Nanjappa, MBBS, MD, Christopher D. Cooper, MD, and John N. Greene, MD Special Report: Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas 446 Evan S. Glazer, MD, PhD, Kevin G. Neill, MD, Jessica M. Frakes, MD, Domenico Coppola, MD, Pamela J. Hodul, MD, Sara E. Hoffe, MD, Jose M. Pimiento, MD, Gregory M. Springett, MD, PhD, and Mokenge P. Malafa, MD, PhD Special Report: A Single-Institution Study of Demographics and Outcomes of Adult Patients 455 With Multiple Cancers Thanh P.