Beta Carotene
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A Comparison of the Anticancer Activities of Dietary Beta-Carotene, Canthaxanthin and Astaxanthin in Mice in Vivo
1: Anticancer Res 1999 May-Jun;19(3A):1849-53 Related Articles, Books, LinkOut A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Chew BP, Park JS, Wong MW, Wong TS. Department Animal Sciences, Washington State University, Pullman 99164-6320, USA. [email protected] The anticancer activities of beta-carotene, astaxanthin and canthaxanthin against the growth of mammary tumors were studied in female eight-wk-old BALB/c mice. The mice were fed a synthetic diet containing 0, 0.1 or 0.4% beta-carotene, astaxanthin or canthaxanthin. After 3 weeks, all mice were inoculated with 1 x 10(6) WAZ-2T tumor cells into the mammary fat pad. All animals were killed on 45 d after inoculation with the tumor cells. No carotenoids were detectable in the plasma or tumor tissues of unsupplemented mice. Concentrations of plasma astaxanthin (20 to 28 mumol/L) were greater (P < 0.05) than that of beta-carotene (0.1 to 0.2 mumol/L) and canthaxanthin (3 to 6 mmol/L). However, in tumor tissues, the concentration of canthaxanthin (4.9 to 6.0 nmol/g) was higher than that of beta-carotene (0.2 to 0.5 nmol/g) and astaxanthin (1.2 to 2.7 nmol/g). In general, all three carotenoids decreased mammary tumor volume. Mammary tumor growth inhibition by astaxanthin was dose-dependent and was higher than that of canthaxanthin and beta-carotene. Mice fed 0.4% beta-carotene or canthaxanthin did not show further increases in tumor growth inhibition compared to those fed 0.1% of each carotenoid. -
International Standard Iso 23443:2020(E)
This preview is downloaded from www.sis.se. Buy the entire standard via https://www.sis.se/std-80022923 INTERNATIONAL ISO STANDARD 23443 First edition 2020-07 Infant formula and adult nutritionals — Determination of β-carotene, lycopene and lutein by reversed-phase ultra-high performance liquid chromatography (RP-UHPLC) Formules infantiles et produits nutritionnels pour adultes — Détermination du bêta-carotène, du lycopène et de la lutéine par chromatographie liquide ultra haute performance à phase inversée Reference number ISO 23443:2020(E) © ISO 2020 This preview is downloaded from www.sis.se. Buy the entire standard via https://www.sis.se/std-80022923 ISO 23443:2020(E) COPYRIGHT PROTECTED DOCUMENT © ISO 2020 All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below or ISO’s member body in the country of the requester. ISO copyright office CP 401 • Ch. de Blandonnet 8 CH-1214 Vernier, Geneva Phone:Website: +41 www.iso.org 22 749 01 11 Email: [email protected] iiPublished in Switzerland © ISO 2020 – All rights reserved This preview is downloaded from www.sis.se. Buy the entire standard via https://www.sis.se/std-80022923 ISO 23443:2020(E) Contents Page Foreword ........................................................................................................................................................................................................................................iv -
BSI Standards Publication
BS ISO 23443:2020 BSI Standards Publication Infant formula and adult nutritionals — Determination of β-carotene, lycopene and lutein by reversed-phase ultra-high performance liquid chromatography (RP-UHPLC) BS ISO 23443:2020 BRITISH STANDARD INTERNATIONAL ISO STANDARD 23443 National foreword This British Standard is the UK implementation of ISO 23443:2020. First edition 2020-07 The UK participation in its preparation was entrusted to Technical Committee AW/34, Food Technical Committee Chairmen. A list of organizations represented on this committee can be obtained on request to its committee manager. This publication does not purport to include all the necessary provisions of a contract. Users are responsible for its correct application. © The British Standards Institution 2020 Published by BSI Standards Limited 2020 Infant formula and adult ISBN 978 0 539 05212 1 nutritionals — Determination of ICS 67.050 β-carotene, lycopene and lutein Compliance with a British Standard cannot confer immunity from by reversed-phase ultra-high legal obligations. performance liquid chromatography This British Standard was published under the authority of the Standards Policy and Strategy Committee on 31 July 2020. (RP-UHPLC) Formules infantiles et produits nutritionnels pour adultes — Amendments/corrigenda issued since publication Détermination du bêta-carotène, du lycopène et de la lutéine par Date Text affected chromatographie liquide ultra haute performance à phase inversée Reference number ISO 23443:2020(E) © ISO 2020 BS ISO 23443:2020 INTERNATIONAL -
Effect of Carotenoids on Aflatoxin B1 Synthesis by Aspergillus Flavus
Postharvest Pathology and Mycotoxins Effect of Carotenoids on Aflatoxin B1 Synthesis by Aspergillus flavus Robert A. Norton USDA, ARS, National Center for Agricultural Utilization Research, Bioactive Agents Research, 1815 N. University, Peoria, IL 61604. Accepted for publication 24 April 1997. ABSTRACT Norton, R. A. 1997. Effect of carotenoids on aflatoxin B1 synthesis by type; lutein was similar to a-carotene and zeaxanthin was similar to ~ Aspergillus flavus. Phytopathology 87:814-821. carotene in inhibition. A mutant accumulating norsolorinic acid (NA), A. parasitiClis SRRC 162, incubated with a-carotene produced reduced levels Carotenes and xanthophylls occurring in yellow corn and related ter of both NA and aflatoxin, indicating that inhibition occurred before NA. penoids were tested for their effect on growth and aflatoxin B 1 produc Additional A. flavus strains tested against 50 Ilg/ml of ~-carotene had 89 tion by Aspergillus flavus NRRL 3357, using the suspended disc culture to 96% inhibition, which was significantly more sensitive than NRRL method. Aflatoxin synthesis was inhibited at concentrations of ~-caro 3357. A. parasiticus strains were less sensitive and generally had similar tene, lutein, and zeaxanthin comparable to those found in the horny en or lower inhibition than NRRL 3357. The results indicate that the pre dosperm of mature corn. Usually growth was not significantly affected. sence of carotenoids in endosperm may decrease the amount of aflatoxin Inhibition of aflatoxin biosynthesis was greater for compounds with an produced by A.flavus. a-ionone-type ring (a-carotene, lutein, or a-ionone) compared with com pounds with a ~-ionone ring. The presence of hydroxy groups on the rings Additional keywords: aflatoxin inhibition, ionones. -
Raspberry Pomace - Composition, Properties and Application
View metadata, citation and similar papers at core.ac.uk brought to you by CORE European Journal ISSN 2449-8955 Review Article of Biological Research Raspberry pomace - composition, properties and application Agnieszka Joanna Brodowska Institute of General Food Chemistry, Faculty of Biotechnology and Food Sciences, Łódź University of Technology, Stefanowskiego 4/10, 90-924 Łódź, Poland * Corresponding author: Agnieszka Brodowska; E-mail: [email protected] Received: 19 February 2017; Revised submission: 24 March 2017; Accepted: 03 April 2017 Copyright: © The Author(s) 2017. European Journal of Biological Research © T.M.Karpi ński 2017. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. DOI : http://dx.doi.org/10.5281/zenodo.495190 ABSTRACT industry by-product, is considered as a potential food ingredient. Its pomace contains plenty of Raspberry pomace can be valorised due to its valuable components such as carbohydrates, nutritionally favourable effect on human health. proteins, fats, fibre, flavours, pectins, vitamins, It is an important source of polyphenols, ellagic similar to the composition of whole raspberries [2]. acid, ellagitannins, tocopherols, unsaturated fatty Moreover, raspberry pomace is rich in a large group acids, and dietary fibre. Thus, raspberry pomace of various phenolics especially ellagitannins, can be considered as a potential raw material to proanthocyanidins, anthocyanins, flavonols, and receive products rich in polyphenols or dietary phenolic acids (especially, ellagic acid) which are fibre, which can provide healthy properties to food also predominant in berries [3]. -
Carotenoids Up-Regulate Connexin43 Gene Expression Independent of Their Provitamin a Or Antioxidant Properties1
(CANCER RESEARCH 52, 5707-5712, October 15, 1992] Carotenoids Up-Regulate Connexin43 Gene Expression Independent of Their Provitamin A or Antioxidant Properties1 Li-Xin Zhang, Robert V. Cooney, and John S. Bertram2 Molecular Oncology Unit, Cancer Research Center of Hawaii. University of Hawaii, Honolulu, Hawaii 96813 ABSTRACT their antioxidant capabilities were not. Neither activity was associated with the provitamin status of the various carotenoids Epidemiological evidence and studies in whole animals and cell cul tested (16). ture have indicated that carotenoids have cancer chemopreventive ac Here, we explore the mechanism by which various caro tion. In mouse C3H10T1/2 cells, this activity is highly correlated with the ability of carotenoids to up-regulate gap junctional intercellular tenoids elevate junctional communication. Gap junctions are communication. Here, we report that in mouse cells, carotenoids in composed of transmembrane proteins called connexins, which crease the expression of connexM.ì,a gene that encodes a major gap form a family of proteins (17). One member of this family, junction protein. This effect appears unrelated to their provitamin A Cx43,3 is a major gap junctional protein in various mammalian or antioxidant properties, since carotenoids with and without provitamin cells including 10T1/2 cells (18). The data indicate that caro A activity increased levels of connexin43 mRNA and protein, whereas tenoids enhance gap junctional communication by increasing the antioxidants methyl-bixin and a-tocopherol were inactive. More the levels of Cx43 mRNA and protein. This effect appears over, the active carotenoid canthaxanthin did not induce the vitamin unrelated to their provitamin A activity or antioxidant proper A-inducible gene retinoic acid receptor-0. -
Natural Colour Book
THE COLOUR BOOK Sensient Food Colors Europe INDEX NATURAL COLOURS AND COLOURING FOODS INDEX 46 Lycopene 4 We Brighten Your World 47 Antho Blends – Pink Shade 6 Naturally Different 48 Red Cabbage 8 The Colour of Innovation 49 Beetroot – with reduced bluish tone 10 Natural Colours, Colouring Foods 50 Beetroot 11 Cardea™, Pure-S™ 51 Black Carrot 12 YELLOW 52 Grape 14 Colourful Impulses 53 Enocianin 15 Carthamus 54 Red Blends 16 Curcumin 56 VIOLET & BLUE 17 Riboflavin 59 Violet Blends 18 Lutein 61 Spirulina 19 Carrot 62 GREEN 20 Natural Carotene 65 Green Blends 22 Beta-Carotene 66 Copper-Chlorophyllin 24 Annatto 67 Copper-Chlorophyll 25 Yellow/ Orange Blends 68 Chlorophyll/-in 26 ORANGE 69 Spinach 29 Natural Carotene 70 BROWN 30 Paprika Extract 73 Burnt Sugar 32 Carrot 74 Apple 33 Apocarotenal 75 Caramel 34 Carminic Acid 76 BLACK & WHITE 35 Beta-Carotene 79 Vegetable Carbon 36 RED 80 Titanium Dioxide 39 Antho Blends – Strawberry Shade 81 Natural White 40 Aronia 41 Elderberry 83 Regulatory Information 42 Black Carrot 84 Disclaimer 43 Hibiscus 85 Contact Address 44 Carmine 3 INDEX NATURAL COLOURS AND COLOURING FOODS WE BRIGHTEN YOUR WORLD Sensient is as colourful as the world around us. Whatever you are looking for, across the whole spectrum of colour use, we can deliver colouring solutions to best meet your needs in your market. Operating in the global market place for over 100 years Sensient both promises and delivers proven international experience, expertise and capabilities in product development, supply chain management, manufacture, quality management and application excellence of innovative colours for food and beverages. -
Pigment Palette by Dr
Tree Leaf Color Series WSFNR08-34 Sept. 2008 Pigment Palette by Dr. Kim D. Coder, Warnell School of Forestry & Natural Resources, University of Georgia Autumn tree colors grace our landscapes. The palette of potential colors is as diverse as the natural world. The climate-induced senescence process that trees use to pass into their Winter rest period can present many colors to the eye. The colored pigments produced by trees can be generally divided into the green drapes of tree life, bright oil paints, subtle water colors, and sullen earth tones. Unveiling Overpowering greens of summer foliage come from chlorophyll pigments. Green colors can hide and dilute other colors. As chlorophyll contents decline in fall, other pigments are revealed or produced in tree leaves. As different pigments are fading, being produced, or changing inside leaves, a host of dynamic color changes result. Taken altogether, the various coloring agents can yield an almost infinite combination of leaf colors. The primary colorants of fall tree leaves are carotenoid and flavonoid pigments mixed over a variable brown background. There are many tree colors. The bright, long lasting oil paints-like colors are carotene pigments produc- ing intense red, orange, and yellow. A chemical associate of the carotenes are xanthophylls which produce yellow and tan colors. The short-lived, highly variable watercolor-like colors are anthocyanin pigments produc- ing soft red, pink, purple and blue. Tannins are common water soluble colorants that produce medium and dark browns. The base color of tree leaf components are light brown. In some tree leaves there are pale cream colors and blueing agents which impact color expression. -
Assessing the Fatty Acid, Carotenoid, and Tocopherol Compositions of Seeds from Apple Cultivars (Malus Domestica Borkh.) Grown in Norway
foods Article Assessing the Fatty Acid, Carotenoid, and Tocopherol Compositions of Seeds from Apple Cultivars (Malus domestica Borkh.) Grown in Norway Milica Fotiri´cAkši´c 1, Kristina Lazarevi´c 2, Sandra Šegan 3 , Maja Nati´c 4 , Tomislav Tosti 4 , Ivanka Ciri´c´ 5 and Mekjell Meland 6,* 1 Faculty of Agriculture, University of Belgrade, 11080 Belgrade, Serbia; [email protected] 2 Centre for Food Analysis, 11080 Belgrade, Serbia; [email protected] 3 Institute of Chemistry, Technology, and Metallurgy, University of Belgrade, 11000 Belgrade, Serbia; [email protected] 4 Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia; [email protected] (M.N.); [email protected] (T.T.) 5 Innovation Centre of Faculty of Chemistry Ltd., 11000 Belgrade, Serbia; [email protected] 6 Norwegian Institute of Bioeconomy Research, NIBIO Ullensvang, Ullensvangvegen 1003, N-5781 Lofthus, Norway * Correspondence: [email protected] Abstract: Apple production generates large amounts of apple pomace including seeds, leading to high transportation costs, public health hazards and undesirable odor. A new reuse strategy of this kind of waste could solve environmental issues and/or create unconventional sources of health Citation: Akši´c,M.F.; Lazarevi´c,K.; beneficial products. In total, seeds from 75 apple cultivars grown in Norway (both domestic and Šegan, S.; Nati´c,M.; Tosti, T.; Ciri´c,I.;´ international) have been analyzed for the first time for oil content and fatty acid profile together with Meland, M. Assessing the Fatty Acid, tocopherols and carotenoids quantification in defatted seeds. Seeds from cultivar Håkonseple had Carotenoid, and Tocopherol the highest oil content (22.10%), with linoleic, oleic acid, and palmitic acid as the most abundant Compositions of Seeds from Apple β α Cultivars (Malus domestica Borkh.) fatty acids. -
Free Radicals in Biology and Medicine Page 0
77:222 Spring 2005 Free Radicals in Biology and Medicine Page 0 This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine (77:222, Spring 2005) offered by the Free Radical and Radiation Biology Program B-180 Med Labs The University of Iowa Iowa City, IA 52242-1181 Spring 2005 Term Instructors: GARRY R. BUETTNER, Ph.D. LARRY W. OBERLEY, Ph.D. with guest lectures from: Drs. Freya Q . Schafer, Douglas R. Spitz, and Frederick E. Domann The Fine Print: Because this is a paper written by a beginning student as an assignment, there are no guarantees that everything is absolutely correct and accurate. In view of the possibility of human error or changes in our knowledge due to continued research, neither the author nor The University of Iowa nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirm the information contained herein with other sources. All material contained in this paper is copyright of the author, or the owner of the source that the material was taken from. This work is not intended as a threat to the ownership of said copyrights. S. Jetawattana Lycopene, a powerful antioxidant 1 Lycopene, a powerful antioxidant by Suwimol Jetawattana Department of Radiation Oncology Free Radical and Radiation Biology The University -
Canthaxanthin, a Red-Hot Carotenoid: Applications, Synthesis, and Biosynthetic Evolution
plants Review Canthaxanthin, a Red-Hot Carotenoid: Applications, Synthesis, and Biosynthetic Evolution Bárbara A. Rebelo 1,2 , Sara Farrona 3, M. Rita Ventura 2 and Rita Abranches 1,* 1 Plant Cell Biology Laboratory, Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA), Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal; [email protected] 2 Bioorganic Chemistry Laboratory, Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA), Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal; [email protected] 3 Plant and AgriBiosciences Centre, Ryan Institute, NUI Galway, H19 TK33 Galway, Ireland; [email protected] * Correspondence: [email protected] Received: 14 July 2020; Accepted: 13 August 2020; Published: 15 August 2020 Abstract: Carotenoids are a class of pigments with a biological role in light capture and antioxidant activities. High value ketocarotenoids, such as astaxanthin and canthaxanthin, are highly appealing for applications in human nutraceutical, cosmetic, and animal feed industries due to their color- and health-related properties. In this review, recent advances in metabolic engineering and synthetic biology towards the production of ketocarotenoids, in particular the red-orange canthaxanthin, are highlighted. Also reviewed and discussed are the properties of canthaxanthin, its natural producers, and various strategies for its chemical synthesis. We review the de novo synthesis of canthaxanthin and the functional β-carotene ketolase enzyme across organisms, supported by a protein-sequence-based phylogenetic analysis. Various possible modifications of the carotenoid biosynthesis pathway and the present sustainable cost-effective alternative platforms for ketocarotenoids biosynthesis are also discussed. Keywords: canthaxanthin; metabolic engineering; carotenoid biosynthesis pathway; plant secondary metabolite; chemical synthesis 1. -
(Se, Vitamin E and Carotenoids) in Broiler Diets on the Growth
Brazilian Journal of Poultry Science Revista Brasileira de Ciência Avícola The Effects of Different Types of Antioxidants (Se, ISSN 1516-635X Jan - Mar 2016 / v.18 / n.1 / 101-116 Vitamin E and Carotenoids) in Broiler Diets on the Growth Performance, Skin Pigmentation and Liver http://dx.doi.org/10.1590/18069061-2015-0155 and Plasma Antioxidant Concentrations Author(s) ABSTracT Karadas FI This study investigated the effects of the addition of different Erdoğan SI antioxidants to broiler diets on their live performance, liver antioxidant Kor DI Oto GII composition and concentrations, immune response, and meat and skin Uluman MIII color. A total of 945 three-day-old Ross 308 broiler chicks of both genders were randomly allocated to one of nine dietary treatments (n=105), with I Yüzüncü Yıl University Agriculture Faculty, three replicates 35 chicks per pen, as follows: T1: control (commercially Department of Animal Science, Van, Turkey II Yüzüncü Yıl University Research Hospital, available corn-and soybean-based broiler diet); T2: selenium Department of Pharmacy, Van, Turkey (control+0.5 mg/kg Sel-PlexTMSe yeast); T3: vitamin E (control+200 mg/ III Kars Directorate of Provincial Food Agricul- kg Kavimix-E-50 α-tocopherol acetate); T4: lutein (control+100 mg/kg ture and Livestock 5% Lutein Beads XB); T5: lycopene (control+100 mg/kg 5% Lyco Beads XB);T6: canthaxanthin (control+25 mg/kg 10% Carophyll®Red);T7: apo- ester (control+25 mg/kg 10% Carophyll®Yellow); T8: lutein+zeaxanthin (control+25 mg/kg Xamacol®); and T9: β-carotene (control+100 mg/kg 10% Rovimix®). Feed (starter, grower, developer and finisher phases) and water were provided ad libitum for 42 days.