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Bioanalytical Methods

BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Acetaminophen 0.25 μg/ml Plasma LC/MS/MS Acetaminophen/ 100 / 5 ng/ml Plasma LC/MS/MS Albuterol 0.5 ng/ml Plasma GC/MS Aldosterone 25 pg/ml Serum ELISA Alendronate 1 / 0.5 ng/ml Urine/Plasma LC/MS/MS Alkaline Hematin (Menstrual Blood) 3 ml Feminine Hygeine Prod. Colorimetric Allopurinol / Oxypurinol 50 /100 ng/ml Plasma LC/MS/MS Alprazolam 50 pg/ml Plasma GC/MS Alprazolam 0.5 ng/ml Plasma LC/MS/MS Aluminum 5/2 ng/ml Plasma/Urine ICP/MS Amikacin 0.15 ug/ml Serum LC/MS/MS 5-Aminosalicylic acid/N-acetyl-5-aminosalicylic acid 10/20 ng/ml Plasma LC/MS/MS / Desethylamiodarone 10 / 10 ng/ml Plasma LC/MS/MS 200 pg/ml Plasma LC/MS/MS Amlodipine 50 pg/ml Plasma LC/MS/MS 100 pg/ml Plasma/Serum GC/MS Articaine 10 ng/ml Plasma/Urine GC/MS Articainic Acid 20 ng/ml Plasma/Urine GC/MS 10 ng/ml Plasma LC/MS/MS Atenolol 250 ng/ml Urine LC/MS/MS Atorvastatin/O-hydroxy/P-hydroxy atorvastatin 200/100/20 pg/ml Plasma LC/MS/MS 50 pg/ml Plasma GC/MS 10 ng/ml Plasma LC/MS/MS Azathioprine/6-Mercaptopurine 1/1 ng/ml Plasma LC/MS/MS Azithromycin 2 ng/ml Plasma LC/MS/MS Benazepril / Benazeprilat 5 / 10 ng/ml Plasma LC/MS/MS Benidipine 50 pg/ml Plasma GC/MS 5 pg/ml Plasma LC/MS/MS Betamethasone 50 pg/ml Plasma GC/MS B icalutamide 2.5 ng/ml Plasma LC/MS/MS 250 pg/ml Plasma GC/MS Bismuth 0.5 ng/ml Plasma ICP-MS 0.2 ng/ml Plasma LC/MS/MS Boswellic Acid 50 ng/ml Plasma GC/MS Bromine 0.5 μg/ml Plasma ICP/MS 2.5 pg/ml Plasma LC/MS/MS 0.5 ng/ml Plasma LC/MS/MS Budesonide/16-OH Budesonide/16-OH Prednisolone 0.1/0.1/0.5 ng/ml Plasma LC/MS/MS Buprenorphine 25 pg/ml Plasma GC/MS Buprenorphine / Norbuprenorphine 5 / 5 pg/ ml Plasma LC/MS/MS / 1-PP 100 pg/ml Plasma LC/MS/MS Butorphanol 20 pg/ml Plasma LC/MS/MS Canrenone 2 ng/ml Plasma LC/MS/MS Canrenone 20 ng/ml Urine LC/MS/MS Capric Acid 100 ng/ml Plasma LC/MS/MS 0.1 ng/ml Plasma LC/MS/MS 2 ng/ml Plasma LC/MS/MS Chlorhexidine 25 ng/ml Saliva LC/MS/MS Chlormadinone Acetate 50 pg/ml Plasma GC/MS 100 pg/ml Plasma LC/MS/MS Citric Acid 50 ng/ml Urine LC/MS/MS Clarithromycin 10 ng/ml Plasma LC/MS/MS

This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services

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BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology 100 pg/ml Plasma GC/MS 0.2 ng/ml Plasma / Urine GC/MS Clindamycin 100 ng/ml Plasma LC/MS/MS Clonazepam 100 pg/ml Plasma LC/MS/MS 25 pg/ml Plasma GC/MS 0.1 ng/ml Plasma LC/MS/MS Codeine 1 ng/ml Plasma LC/MS/MS Cortisol 1 Ng/ml Plasma LC/MS/MS 0.1 ng/ml Plasma LC/MS/MS Cyclosporin 10 ng/ml Whole Blood LC/MS/MS Cyproterone Acetate 25 pg/ml Pla sma/Serum GC/MS Desmopressin 2.5 pg/ml Plasma LC/MS/MS Desogestrel (3-keto-desogestrel) 25 pg/ml Plasma GC/MS Desogestrel (3-keto-desogestrel) /Ethinylestradiol 25/2.5 pg/ml Plasma GC/MS Dexamethasone 0.25 ng/ml Plasma LC/MS/MS Diclofenac 5 ng/ml Plasma LC/MS/MS Dienogest 0.5 ng/ml Plasma LC/MS/MS Digoxin 1 ng/ml Urine LC/MS/MS Digoxin 1 ng/ml Plasma LC/MS/MS Diltiazem / Desmethyldiltiazem / Desacetyldiltiazem 4/2/1 ng/ml Plasma LC/MS/MS Diph enydramine 1 ng/ml Plasma LC/MS/MS Disulfiram (as Methyl Diethydithiocarbamate) 1.0 ng/ml Plasma GC/MS Docetaxel 2.5 ng/ml Plasma LC/MS/MS Doxorubicin 1.5 ng/ml Urine LC/MS/MS Doxorubicin / Doxorubicinol 0.5 / 0.5 ng/ml Plasma LC/MS/MS Doxycycline 0.1 ng/ml Plasma LC/MS/MS Dronabinol/11-OH-Dronabinol 200/200 pg/ml Plasma LC/MS/MS Drospirenone 100 pg/ml Plasma LC/MS/MS Dydrogesterone 50 pg/ml Plasma GC/MS Enalapril & Enalaprilat 250 pg/ml Plasma LC/MS/MS Eprosartan 1 ng/ml Plasma LC/MS/MS 25 pg/ml Plasma LC/MS/MS Estradiol / Estrone 5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 2.5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 1 / 2 pg/ml Serum GC/MS Estradiol / Estrone 50 / 100 pg/ml Rat Plasma/Serum GC/MS Estriol 10.0 pg/ml Plasma/Serum GC/MS Free Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 5/5/2.5/2.5 pg/ml Plasma GC/MS Total Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 50/50/10/10 pg/ml Plasma GC/MS Estrone Sulfate 50 pg/ml Plasma LC/MS/MS Estrone Sulfate 50 pg/ml Plasma GC/MS EthinylEstradiol 1 pg/ml Plasma GC/MS Ethinylestradiol 2.5 pg/ml Plasma GC/MS Ethinylestradiol / Norethindrone 2.5 / 25 pg/ml Plasma GC/MS Ethinylestradiol / Norgestrel (levonorgestrel) 10 / 50 pg/ml Serum GC/MS Etoposide 0.5 ng/ml Plasma LC/MS/MS Exemestane 50 pg/ml Plasma LC/MS/MS 2 ng/ml Plasma LC/MS/MS Felodipine 50 pg/ml Plasma GC/MS Felodipine 25 ng/ml Plasma LC/MS/MS Fenofibric Acid 10 ng/ml Plasma LC/MS/MS Fentanyl 25 pg/ml Plasma LC/MS/MS LABORATORY SERVICES

Bioanalytical Methods

BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Finasteride 0.5 ng/ml Plasma LC/MS/MS / MFCA metabolite 0.1/50 ng/ml Plasma LC/MS/MS/HPLC UV Fludrocortisone 25 pg/ml Plasma GC/MS Flunisolide 50 pg/ml Plasma GC/MS 25 pg/ml Plasma GC/MS Flutamide / Hydroxyflutamide 20/2 pg/ml Plasma GC/MS Fluticasone/ 2.5 pg/ml Plasma LC/MS/MS 200 pg/ml Plasma LC/MS/MS Fosinoprilat 5 ng/ml Plasma LC/MS/MS Fur nidipine 25 pg/ml Plasma GC/MS Furosemide 50 ng/ml Plasma LC/MS/MS Gabapentin 50 ng/ml Plasma LC/MS Gadolinium 1μg/ml Serum/Urine ICP/MS Gemfibrozil 200 ng/ml Plasma LC/MS/M Gliclazide 5 ng/ml Plasma LC/MS/MS Glimepiride 1 ng/ml Serum LC/MS/MS Glycopyronium 1.0 pg/ml Plasma LC/MS/MS Goserelin 0.2 ng/ml Plasma LC/MS/MS Guaifenesin 2.5 ng/ml Plasma LC/MS/MS 25 pg/ml Plasma LC/MS/MS Homocysteine 5μg/ml Plasma LC/MS/MS Hydrocodone 0.25 ng/ml Plasma LC/MS/MS Hydromorphone 20.0 pg/ml Plasma LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4- 10 ng/ml Plasma/Saliva LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4- 0.1 μg/ml Urine LC/MS/MS Hydroxymidazolam, a / Hydroxymidazolam, 4- 2 / 2 ng/ml Plasma LC/MS/MS 2-Hydroxypropyl-beta-cyclodextrin 0.1 μg/ml Plasma LC/MS 50 pg/ml Plasma GC/MS Ibuprofen 0.25 μg/ml Plasma LC/MS/MS Ibuprofen R- / S- 0.25 μg/ml Plasma LC/MS/MS Iloprost 10 pg/ml Plasma LC/MS/MS / 0.10 ng/ml Plasma LC/MS/MS Indapamide 0.5 ng/ml Plasma LC/MS/MS Indomethacin 20 ng/ml Plasma LC/MS/MS Interferon alpha 10 pg/ml Serum ELISA Iodine 0.5/5 μg/ml Whole Blood/Urine ICP/MS Irbesartan 5 ng/ml Plasma LC/MS/MS Isosorbide Dinitrate 0.1 ng/ml Plasma GC/MS Isosorbide-2-mononitrate 0.25 ng/ml Plasma GC/MS Isosorbide-5-mononitrate 0.25 ng/ml Plasma GC/MS Isotreti noin / 4-Oxo-Isotretinoin 10 ng/ml Plasma LC/MS/MS Isradapine 100 pg/ml Plasma LC/MS/MS Ketoprofen 1 ng/ml Plasma LC/MS/MS Ketoprofen 50 ng/ml Urine GC/MS 25 pg/ml Plasma GC/MS Lacidipine 20 pg/ml Plasma LC/MS/MS Lamotrigine 10 ng/ml Plasma LC/MS/MS Lercanidipine R- & S- 20 pg/ml Plasma LC/MS/MS Letrozole 10 ng/ml Plasma LC/MS/MS Leuprolide 0.04 ng/ml Plasma EIA Levofloxacin 0.2 μg/ml Plasma LC/MS/MS Levonorgestrel 10 pg/ml Plasma/Serum GC/MS

This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services

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BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Lisinopril 1 ng/ml Plasma LC/MS/MS 10 pg/ml Plasma LC/MS/MS Lithium 25 ng/ml Serum ICP/MS Loperamide 125 pg/ml Plasma GC/MS / Descarboethoxyloratadine 100/50 pg/ml Plasma GC/MS Lorazepam 1.0 ng/ml Plasma LC/MS/MS Lynestrenol 0.1 ng/ml Plasma GC/MS Medrogestone 50 pg/ml Plasma GC/MS Medroxyprogesterone Acetate 0.1 ng/ml Plasma/Serum GC/MS Megesterol Acetate 100 pg/ml Plasma GC/MS Melatonin 5 pg/ml Plasma LC/MS/MS Meloxicam 10 ng/ml Plasma LC/MS/MS 0.25 ng/ml Plasma GC/MS 100 pg/ml Plasma GC/MS Mephenytoin (R,S) Phenotyping Urine GC/MS R-Mephenytoin / S-Mephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 0.1 μg/ml Urine LC/MS/MS R-Mephenytoin / S-Mephenytoin 0.1 μg/ml Urine LC/MS/MS Metformin 10 ng/ml Plasma LC/MS/MS 100 pg/ml Plasma/Serum GC/MS Methoxyestradiol/Methoxyestrone 5 pg/ml Plasma GC/MS Methylnicotinamide 10 ng/ml Plasma LC/MS/MS 100 pg/ml Plasma LC/MS/MS Methylprednisolone 0.5 ng/ml Plasma LC/MS/MS Methyltestosterone 50 pg/ml Plasma GC/MS 1.00 ng/ml Plasma LC/MS/MS Midazolam 0.5 ng/ml Plasma GC/MS-LC/MS Minocycline 0.27 ng/ml Plasma LC/MS/MS 0.5 ng/ ml Plasma GC/MS Misoprostol Acid 10 pg/ml Serum LC/MS/MS Moexipril 1 ng/ml Plasma LC/MS/MS Molindone 250 pg/ml Plasma LC/MS/MS Morphine / Morphine-3-glucuronide / Morpine-6-glucuronide 0.5/5/2 ng/ml Plasma LC/MS/MS Moxonidine 0.05/1 ng/ml Plasma/Urine GC/MS Mycophenolic Acid / Mycophenolic Acid Glucuronide 0.1/0.5 ug/ml Dog Plasma LC/MS/MS Niacin (Nicotinic Acid) / Nicotinuric acid 25 ng/ml Plasma LC/MS/MS Nicardipine 25 pg/ml Plasma GC/MS Nico randil 1 ng/ml Plasma GC/MS Nicotinamide 10 ng/ml Plasma LC/MS/MS Nicotine / Cotinine 0.5/2.5 ng/ml Plasma GC/MS Nilvadipine 50 pg/ml Plasma GC/MS R-Nirvanol / S-Nirvanol 20 ng/ml Plasma/Saliva LC/MS/MS R-Nirvanol / S-Nirvanol 0.25 μg/ml Urine LC/MS/MS Nitisonon 1 ng/ml Plasma LC/MS/MS Nitrendipine 50 pg/ml Plasma GC/MS Nitroglycerin / 1,2 GDN / 1,3 GDN 5/20/10 pg/ml Plasma GC/MS Norethindrone 25 pg/ml Plasma GC/MS Norgestimate / 17-Desacetylnorgesti mate 100 pg/ml Plasma LC/MS/MS Norgestrel 0.1 ng/ml Plasma GC/MS Octreotide 25 pg/ml Plasma LC/MS/MS 0.5 ng/ml Plasma LC/MS/MS LABORATORY SERVICES

Bioanalytical Methods & Equipment

BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Oxandrolone 0.25 ng/ml Plasma LC/MS/MS Oxeladin 1 ng/ml Plasma GC/MS / N-Desethyloxybutynin 0.1/0.25 ng/ml Plasma/Serum LC/MS Oxycodone and Noroxycodcone 0.25 ng/ml Plasma LC/MS/MS Pantoprazole 10 ng/ml Plasma LC/MS/MS 100 pg/ml Plasma LC/MS/MS Pentaerythrityl Mononitrate & Dinitrate 50 pg/ml Plasma GC/MS Pentoxyverine 1 ng/ml Plasma GC/MS Permetrexed 10 ng/ml Plasma LC/MS/MS PGF2 (9-alpha, 11-beta PGF2) 25 pg/ml Plasma LC/MS/MS Platinum 2.5 ng/ml Plasma ICP/MS Potassium 1 mM Urine Ion Selective Electrode Pravastatin 0.5 ng/ml Plasma LC/MS/MS Primidone 25 ng/ml Plasma LC/MS/MS Progesterone 100 pg/ml Plasma LC/MS/MS 200 pg/ml Plasma LC/MS/MS and N-despropyl- & 5-Hydroxypropafenone 250 pg/ml Plasma LC/MS/MS Propoxyphene / Acetaminophen 1 / 50 ng/ml Plasma LC/MS/MS Propoxyphene / Norpro poxyphene 1 ng/ml Plasma LC/MS/MS PSA 360 pg/ml Serum EIA /Ibuprofen 2/200 ng/ml Plasma LC/MS/MS Quercetin 0.25 μg/ml Plasma LC/MS/MS Repaglinide 200 pg/ml Serum LC/MS/MS Ribavirin 25 ng/ml Plasma LC/MS/MS Risedronic Acid 0.1 / 0.2 ng/ml Plasma / Urine LC/MS/MS 0.1 ng/ml Plasma LC/MS/MS Rivastigmine 0.1 ng/ml Plasma LC/MS/MS Ropinirole 20 pg/ml Plasma LC/MS/MS Rosuvastatin 0.25 ng/ml Plasma LC/MS/MS Free 25 pg/ml Pla sma GC/MS Scopolamine Free 100 pg/ml Urine GC/MS Selegiline 50 pg/ml Plasma/Serum GC/MS Desmethylselegiline / Methamphetamine / Amphetamine 100 pg/ml Plasma/Serum GC/MS 250 pg/ml Plasma GC/MS SHBG 10 nmol/L Plasma/Serum ELISA Simvastatin / Simvastatin Hydroxyacid 0.5/0.5 ng/ml Plasma LC/MS/MS Sitagliptin 100 pg/ml Plasma LC/MS/MS Sirolimus 1 Ng/ml Blood LC/MS/MS Sparteine / 2-DHSP / 5-DHSP 0.5 nmol/L Urine GC/MS Spironolactone 2 ng/m l Plasma LC/MS/MS Strontium 100 ng/ml Plasma ICP/MS 0.5 ng/ml Plasma LC/MS/MS T3/T4 0.3/10 ng/ml Serum LC/MS/MS Tacrolimus 0.5 ng/ml Blood LC/MS/MS Temazepam 25 ng/ml Plasma LC/MS/MS Terbinafine / N-desmethylterbinafine 40 Pg/ml Plasma LC/MS/MS 0.1 ng/ml Plasma GC/MS Testosterone / 5-α-Dihydrotestosterone 50 pg/ml Plasma GC/MS Testosterone 100 pg/ml Plasma LC/MS/MS 100 pg/ml Plasma LC/MS/MS Tolperisone 500 pg/ml Plasma LC/MS/MS / 5-hydroxymethyl tolterodine 100 pg/ml Plasma LC/MS/MS Topiramate 10 ng/ml Plasma LC/MS/MS

This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services

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BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Tramadol/Acetaminophen 5/100 ng/nl Plasma LC/MS/MS Tranexamic Acid 50 ng/ml Plasma GC/MS 10 ng/ml Plasma LC/MS/MS Triamterene 2 ng/ml Plasma LC/MS/MS Triazolam 50 pg/ml Plasma GC/MS Trospium 20 pg/ml Plasma LC/MS/MS / O-desmethylvenlafaxine 2.5 ng/ml Plasma LC/MS/MS Vinorelbine 1 ng/ml Blood LC/MS/MS Voriconazole 25 ng/ml Plasma (Dog) LC/MS/MS Zolpidem 1 ng/ml Plasma LC/MS/MS

BIOANALYTICAL EQUIPMENT LC-MS-MS GC-MS ICP-MS Mass Spectromentry 2 PE Sciex API 6500/UPLC 2 Thermo Scientific DSQ II 1 Perkin Elmer Elan DRC II Mass Spectromentry 6 PE Sciex API 5500/UPLC Mass Spectromentry 2 PE Sciex API 5000 Mass Spectromentry 7 PE Sciex API 4000 Mass Spectromentry 1 PE Sciex API 3000

BIOANALYTICAL EQUIPMENT Clinical Laboratory Roche Cobas 6000 Clinical Laboratory Roche Integra 400 plus Clinical Laboratory Sysmex XT 2000i Clinical Laboratory Roche Cobas t 411 Clinical Laboratory Roche Cobas u 411

BIOANALYTICAL EQUIPMENT Immunoassay FACS Calibur and Canto II Flow Cytometers Immunoassay Tecan M200 Pro ELISA Readers Immunoassay Meso Scale Discovery QuickPlex SQ 120 Systems Immunoassay Singulex Erenna SMC (Single Molecule Counting) withUltra High Sensitivity Reader Immunoassay Molecular biology equipment e.g. PCR, Gel Electrophoresis Immunoassay Fully equipped tissue culture lab incl. three sterile work benches, two CO2-incubators, liquid nitrogen specimen storage tank

FOR REDEVELOPMENT / REVALIDATION BY LC-MS/MS BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Acebutalol / 5 ng/ml Plasma HPLC/UV Acetaminophen 0.1 μg/ml Plasma/Urine HPLC/UV N-Acetylcysteine 100 ng/ml Plasma HPLC/UV Acetylsalicylic acid/Salicylic acid 25/50 ng/ml Plasma HPLC/UV Acyclovir 20 ng/ml Plasma HPLC/FL Acyclovir 1μg/ml Urine HPLC/FL 250 pg/ml Plasma HPLC/Fl Ambroxol 1 ng/ml Plasma HPLC/UV Amiloride 1 ng/ml Plasma HPLC/FL Aminoguanidine 50 ng/ml Plasma HPLC/EC 5-Aminosalicylic acid 2μg/ml Urine HPLC/FL 5-Aminosalicylic acid 1 ng on col Feces HPLC/FL LABORATORY SERVICES

For Redevelopment & Revalidation by LC-MS/MS

BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Amitriptyline / / Amitriptylline-N-oxide 0.5/0.5/50 ng/ml Plasma HPLC/UV Amoxicillin 0.25 μg/ml Plasma HPLC/UV Ampicillin 0.25 μg/ml Plasma HPLC/UV Anipamil 5 ng/ml Plasma HPLC/FL Antipyrine 0.025 μg/ml Plasma HPLC/UV Antipyrine & metabolites 2.5 μg/ml Urine HPLC/UV / Desmethylastemizole 250/150 pg/ml Plasma HPLC/EC Atenolol R- / S- 20 ng/ml Plasma HPLC/FL Bensera zide 10 ng/ml Plasma HPLC/EC 2 ng/ml Plasma HPLC/Fl Bisoprolol / Bisoprolol Fumerate 2/1 ng/ml Plasma HPLC/FL Bromazepam 1 ng/ml Plasma HPLC/UV Bromhexine / Ambroxol 1 ng/ml Plasma HPLC/UV 2.5 ng/ml Plasma HPLC/UV Butalbital 0.1 μg/ml Plasma HPLC/UV Caffeine 0.05 μg/ml Plasma HPLC/UV Captopril 25 ng/ml Plasma HPLC/EC Carabastine 5 ng/ml Plasma HPLC/UV 0.05 μg/ml Plasma HPLC/UV Carbidopa / Levodopa / 3-O- 2.5/25/25 ng/ml Plasma HPLC/EC RR- & SS-Carboxyibuprofen 2.5 μg/ml Urine HPLC/FL Carboxyibuprofen 5μg/ml Urine HPLC/FL Cefaclor 0.5 μg/ml Plasma HPLC/UV Cefadroxil 0.25 μg/ml Plasma HPLC/UV Cefdinir 25 ng/ml Plasma HPLC/UV Cefixime 50 ng/ml Plasma HPLC/UV Cefprozil 0.25 μg/ml Plasma HPLC/UV Cephalexin 0.25 μg/ml Plasma HPLC/UV Chinin 10 ng/ml Plasma HPLC/UV Chlormezanone 5 ng/ml Plasma HPLC/UV Chlorpropamide 1μg/ml Rat Plasma HPLC/UV Chlorthalidone 10 ng/ml Whole Blood HPLC/UV Chlorthalidone 0.2 μg/ml Urine HPLC/UV 50 ng/ml Plasma HPLC/UV Cimetidine 25 μg/ml Urine HPLC/UV 2 ng/ml Plasma HPLC/UV Ciprofloxacin 25 ng/ml Plasma HPLC/FL Ciprofloxacin 2.0 μg/ml Urine HPLC/FL 5 ng/ml Plasma HPLC/FL Clavulanic Acid 10 ng/ml Plasma HPLC/UV Clobutinol 1 ng/ml Plasma HPLC/UV Cortisone 5 ng/ml Plasma HPLC/UV Danazole 1 ng/ml Serum HPLC/UV 10 ng/ml Plasma HPLC/EC Demeclocycline 100 ng/ml Plasma HPLC/UV / 3-hydroxymorphinan / 4-methoxymorphina 10 ng/ml Plasma HPLC/FL Dextromethorphan / 3-hydroxymorphinan / 4-methoxymorphina 0.25 μg/ml Urine HPLC/FL 10/250 ng/ml Plasma/Urine HPLC/FL Diazepam / Desmethyldiazepam 2 ng/ml Plasma HPLC/UV Diclofenac 10 ng/ml Plasma HPLC/UV Dihydralazine 1 ng/ml Plasma HPLC/UV Dilazep 2.5 ng/ml Whole Blood HPLC NUVISAN ® Pharma Services

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BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Dipyridamole 10 ng/ml Plasma HPLC/FL Disopyramide / N-Desmethyldisopyramide 0.1/0.05 μg/ml Plasma HPLC/UV Domperidone 1.0 ng/ml Plasma HPLC/UV Dothiepin 2 ng/ml Plasma HPLC/UV Dothiepin-S-Oxide 5 ng/ml Plasma HPLC/UV 0.2 ng/ml Plasma HPLC/FL Doxepine / Desmethyldoxepine 0.5 ng/ml Plasma HPLC/UV Doxycycline 50 ng/ml Plasma HPLC/UV 5/100 ng/ml Plasma/Urine HPLC/UV Eb astine 10 ng/ml Plasma HPLC/UV Erythromycin A 0.1 μg/ml Plasma HPLC/EC 10 ng/ml Plasma HPLC/UV Etintidine 100 ng/ml Plasma HPLC/UV Etintidine 10 μg/ml Urine HPLC/UV Etodolac 0.1 μg/ml Plasma HPLC/UV Femoxitine / N-Desmethylfemoxitine 5 ng/ml Plasma HPLC/FL Fenbufen 0.1 μg/ml Plasma HPLC/UV Flavoxate / MFCA metabolite 0.1/50 ng/ml Plasma LC/MS/MS/HPLC UV Fluconazole 50 ng/ml Plasma HPLC/UV Flunitrazepam 0.5 ng/ml Serum HPLC/UV / Norfluoxetine 1 ng/ml Plasma HPLC/UV Flurazepam / N-Hydroxyethyl & N-Desalkyl metabolites 0.75 ng/ml Serum HPLC/UV Flurbiprofen 0.1 μg/ml Plasma HPLC/UV Flurbiprofen R- / S- 0.5 μg/ml Urine HPLC/FL Flurbiprofen R- / S- 0.25 μg/ml Plasma HPLC/FL Furosemide 10 ng/ml Plasma HPLC/FL Gallopamil 2 ng/ml Plasma HPLC/FL Gemcitabine 40 ng/ml Plasma/Urine HPLC/UV Gemfibrozil 0.5 μg/ml Plasma HPLC/UV Glipizide 10 ng/ml Plasma HPLC/UV Glisoxepide 2.5 ng/ml Serum HPLC/UV Glybuerid 5 ng/ml Plasma HPLC/UV 100 pg/ml Plasma HPLC/Fl Homogentisic Acid 0.25 μg/ml Plasma HPLC/UV Hydralazine Free & Apparent 2.5/0.5 ng/ml Plasma/Whole Blood HPLC/FL Hydrochlorothiazide 1 ng/ml Plasma HPLC/UV Hydrochlorothiazide 0.05 μg/ml Urine HPLC/UV Hydrocortisone 5 ng/ml Plasma HPLC/UV 6−β−Hydroxycortisol 0.1 μg/ml Urine HPLC/UV R- & S-Hydroxyibuprofen 2.5 μg/ml Urine HPLC/FL Hypoxanthine 0.25/0.5 μg/ml Plasma/Urine HPLC/UV Indocyanin e Green (ICG) 0.3 μg/ml Plasma HPLC/UV Iodide 0.1 μg/ml Plasma HPLC/UV Isoniazide 0.1 μg/ml Plasma HPLC/UV Ketoconazole 50 ng/ml Plasma HPLC/FL Ketoprofen 5/1000 ng/ml Plasma/Urine HPLC/UV 1 ng/ml Plasma HPLC/FL Levetiracetam 0.5 μg/ml Plasma HPLC/UV 1 ng/ml Plasma HPLC/UV Lornoxicam 25 ng/ml Plasma HPLC/UV Losartan / Losartan Carboxy Acid 10/5 ng/ml Plasma HPLC/Fl Medroxyprogesterone Acetate 4 ng/ml Serum HPLC/UV LABORATORY SERVICES

For Redevelopment & Revalidation by LC-MS/MS

BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology 6-Mercaptopurine 5 ng/ml Plasma HPLC/UV Metamizol 0.3 μg/ml Plasma HPLC/UV Methimazole 10 ng/ml Plasma HPLC/EC Methocarbamol 0.1 μg/ml Plasma HPLC/FL 6-Methoxy-2-Naphthaleneacetic Acid 0.1 μg/ml Plasma HPLC/FL 5-Methyltetrahydrofolic Acid 10 ng/ml Plasma HPLC/UV Methylsalicylate 80 ng/ml Plasma HPLC/FL 1 ng/ml Plasma HPLC/UV Metoclopramide 60 ng/ml Urine HPLC/FL Metolazone 2 ng/ml Plasma HPLC/Fl Metoprolol/Hydroxymetoprolol 2.5/1000 ng/ml Plasma/Urine HPLC/FL Mexiletine 10 ng/ml Plasma HPLC/UV 1 ng/ml Plasma HPLC/UV Minocycline 25 ng/ml Plasma HPLC/UV 0.1/10 ng/ml Plasma/Urine HPLC/FL 5 ng/ml Plasma HPLC/FL Naloxone 1 ng/ml Plasma HPLC/EC Naltrexone / 6-b-Naltrexol 0.1/0.5 ng/ml Plasma HPLC/FL Naproxen 0.5 μg/ml Plasma HPLC/FL 10 ng/ml Plasma HPLC/UV Nicardipine 0.5 ng/ml Plasma HPLC/EC + M1 and M2 Metabolites 0.5 ng/ml Plasma HPLC/UV Nicorandil 50 ng/ml Urine HPLC/UV Nifedipine / NPO 1 ng/ml Plasma HPLC/UV Nimesulide / Hydroxynimesulide 20 ng/ml Plasma HPLC/UV Nitrofurantoin 5 ng/ml Plasma HPLC/UV Nitrofurantoin 2μg/ml Urine HPLC/UV Northiaden / Northiaden-S-Oxide 2/5 ng/ml Plasma HPLC/UV 1 ng/ml Plasma HPLC/UV Oxaprozin 2μg/ml Plasma HPLC/UV Oxazepam 10 ng/ml Plasma HPLC/UV Oxazepam 0.1 μg/ml Urine HPLC /UV 2.5 ng/ml Plasma HPLC/UV Papaverine, 1 ng/ml Plasma HPLC/UV Paraxanthine 25 ng/ml Plasma/Serum HPLC/UV Pelargonidin 10/40 ng/ml Plasma/Urine HPLC/UV Pentoxifylline 4 ng/ml Plasma HPLC/UV Phenoxymethylpenicillin (Penicillin V) 0.1 μg/ml Plasma HPLC/UV 2 ng/ml Plasma HPLC/FL Phenylpropanolamine 5μg/ml Urine HPLC/FL Phenylpropanolamine D- / L- 8.1 ng/ml Plasma (Human/Dog) HPLC/UV Phenylpropanolamin e D- / L- 2.4 ng/ml Urine (Dog) HPLC/UV Phenytoin 0.25 μg/ml Plasma HPLC/UV Free Phenytoin / Phenylhhydantoin / Phenobarbitol 0.1 μg/ml Urine HPLC/UV Phenytoin 1μg/ml Urine HPLC/UV 1 ng/ml Plasma HPLC/UV Piracetam 0.5 μg/ml Plasma HPLC/UV Piroxicam 50 ng/ml Plasma HPLC/UV 0.1 ng/ml Plasma HPLC/FL Prednisolone 1 ng/ml Plasma HPLC/UV Prednisone 1 ng/ml Plasma HPLC/UV Prednyliden 5 ng/ml Plasma HPLC/UV NUVISAN ® Pharma Services

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BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Probucol 0.25 μg/ml Plasma HPLC/UV Procainamide / Acetylprocainamide 0.2 μg/ml Plasma HPLC/UV Propofol 2.5 ng/ml Plasma HPLC/FL / 4-Hydroxypropranolol 2.5 ng/ml Plasma HPLC/FL Propranolol Glucuronide 1μg/ml Urine HPLC/FL Pseudoephedrine 0.5 μg/ml Urine HPLC/UV 10 ng/ml Plasma HPLC/UV Quinine 10 ng/ml Plasma HPLC/UV Quinolone 50/100 ng/ml Plasma/Urine HPLC/UV 5 ng/ml Plasma HPLC/UV 25 pg/ml Plasma HPLC/FL Rifampicin / Desacetylrifampin 0.1 μg/ml Plasma HPLC/UV Rosoxacin 0.1 μg/ml Plasma/Oviduct/Uterus HPLC/UV Salicylic Acid 0.25 μg/ml Plasma HPLC/UV Salicylic Acid 0.7/9.2 μg/ml Plasma/Urine HPLC/FL Salicyluric Acid 25 ng/ml Plasma HPLC/UV Salicyluric Acid 2.5 μg/ml Urine HPLC/UV Sildenafil / N-desmethylsildenafil 1/1 ng/ml Plasma HPLC/UV 50 ng/ml Plasma HPLC/FL Sulfamethoxazole 250 ng/ml Plasma HPLC/UV Sulfamethoxazole 1μg/ml Urine HPLC/UV Sulindac / Sulindacsulfone / Sulindacsulfide 0.25 μg/ml Plasma HPLC/UV Sulpiride 10 ng/ml Plasma HPLC/FL Tamoxifen / N-Desmethyltamoxifen 0.5/0.25 ng/ml Plasma HPLC/FL Telmisartan 500 pg/ml Plasma HPLC/Fl Tenoxicam 20 ng/ml Plasma HPLC/UV 0.25 ng/ml Plasma HPLC/EC Terconazole 0.5 ng/ml Plasma HPLC/EC Terfenadine Metabolite M1 25 ng/ml Plasma HPLC/FL Terfenadine Metabolite M1/M2 250 ng/ml Urine HPLC/FL Tetrazepam 2 ng/ml Plasma HPLC/UV Theophylline 50 ng/ml Plasma HPLC/UV Theophylline 0.2 μg/ml Serum/Plasma HPLC/UV Thiothixene 0.5 ng/ml Serum HPLC/UV Tiaprofenic Acid 100 ng/ml Plasma HPLC/UV Ticlopidine 5 ng/ml Plasma HPLC/UV 2 ng/ml Plasma HPLC/UV Tolbutamide / Carboxytolbutamide / Hydroxytolbutamide 0.25/0.5/0.5 μg/ml Plasma HPLC/UV Tramadol 2.5 ng/ml Plasma HPLC/UV Triamterene / Hydroxytriamterene Sulfate 5/25 ng/ml Plasma HPLC/FL Triamterene / Hydroxytriamterene Sulfate 0.125/1.25 ng/ml Urine HPLC/FL Trimethoprim/Sulfamethoxazole 10/250 ng/ml Plasma HPLC/UV Trimethoprim 1μg/ml Urine HPLC/UV / N-desmethyltrimipramine 2 / 2 ng/ml Plasma HPLC/UV Valsartan 50 ng/ml Plasma HPLC/Fl Verapamil / Norverapamil 2.5 ng/ml Plasma HPLC/FL Veratric Acid 50 ng/ml Plasma HPLC/UV Vitamin E 0.5 μg/ml Plasma HPLC/UV Warfarin R- & S- 50 ng/ml Plasma HPLC/FL Xanthine 0.5/1.0 μg/ml Plasma/Urine HPLC/UV Zatebradine 1.5 ng/ml Plasma HPLC/FL Zonisamide 50 ng/ml Serum HPLC/UV NUVISAN ® Pharma Services

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