DOCSLIB.ORG

Bioanalytical Methods

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Bioanalytical Methods LABORATORY SERVICES BioanalyticalOur resources become yours.Methods [email protected] www.nuvisan.com NUVISAN ® Pharma Services LABORATORY SERVICES Bioanalytical Methods BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Acetaminophen 0.25 μg/ml Plasma LC/MS/MS Acetaminophen/Tramadol 100 / 5 ng/ml Plasma LC/MS/MS Albuterol 0.5 ng/ml Plasma GC/MS Aldosterone 25 pg/ml Serum ELISA Alendronate 1 / 0.5 ng/ml Urine/Plasma LC/MS/MS Alkaline Hematin (Menstrual Blood) 3 ml Feminine Hygeine Prod. Colorimetric Allopurinol / Oxypurinol 50 /100 ng/ml Plasma LC/MS/MS Alprazolam 50 pg/ml Plasma GC/MS Alprazolam 0.5 ng/ml Plasma LC/MS/MS Aluminum 5/2 ng/ml Plasma/Urine ICP/MS Amikacin 0.15 ug/ml Serum LC/MS/MS 5-Aminosalicylic acid/N-acetyl-5-aminosalicylic acid 10/20 ng/ml Plasma LC/MS/MS Amiodarone / Desethylamiodarone 10 / 10 ng/ml Plasma LC/MS/MS Amitriptyline 200 pg/ml Plasma LC/MS/MS Amlodipine 50 pg/ml Plasma LC/MS/MS Amphetamine 100 pg/ml Plasma/Serum GC/MS Articaine 10 ng/ml Plasma/Urine GC/MS Articainic Acid 20 ng/ml Plasma/Urine GC/MS Atenolol 10 ng/ml Plasma LC/MS/MS Atenolol 250 ng/ml Urine LC/MS/MS Atorvastatin/O-hydroxy/P-hydroxy atorvastatin 200/100/20 pg/ml Plasma LC/MS/MS Atropine 50 pg/ml Plasma GC/MS Atomoxetine 10 ng/ml Plasma LC/MS/MS Azathioprine/6-Mercaptopurine 1/1 ng/ml Plasma LC/MS/MS Azithromycin 2 ng/ml Plasma LC/MS/MS Benazepril / Benazeprilat 5 / 10 ng/ml Plasma LC/MS/MS Benidipine 50 pg/ml Plasma GC/MS Betahistine 5 pg/ml Plasma LC/MS/MS Betamethasone 50 pg/ml Plasma GC/MS B icalutamide 2.5 ng/ml Plasma LC/MS/MS Biperiden 250 pg/ml Plasma GC/MS Bismuth 0.5 ng/ml Plasma ICP-MS Bisoprolol 0.2 ng/ml Plasma LC/MS/MS Boswellic Acid 50 ng/ml Plasma GC/MS Bromine 0.5 μg/ml Plasma ICP/MS Bromocriptine 2.5 pg/ml Plasma LC/MS/MS Brompheniramine 0.5 ng/ml Plasma LC/MS/MS Budesonide/16-OH Budesonide/16-OH Prednisolone 0.1/0.1/0.5 ng/ml Plasma LC/MS/MS Buprenorphine 25 pg/ml Plasma GC/MS Buprenorphine / Norbuprenorphine 5 / 5 pg/ ml Plasma LC/MS/MS Buspirone / 1-PP 100 pg/ml Plasma LC/MS/MS Butorphanol 20 pg/ml Plasma LC/MS/MS Canrenone 2 ng/ml Plasma LC/MS/MS Canrenone 20 ng/ml Urine LC/MS/MS Capric Acid 100 ng/ml Plasma LC/MS/MS Carvedilol 0.1 ng/ml Plasma LC/MS/MS Cetirizine 2 ng/ml Plasma LC/MS/MS Chlorhexidine 25 ng/ml Saliva LC/MS/MS Chlormadinone Acetate 50 pg/ml Plasma GC/MS Citalopram 100 pg/ml Plasma LC/MS/MS Citric Acid 50 ng/ml Urine LC/MS/MS Clarithromycin 10 ng/ml Plasma LC/MS/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services Our recources become yours. BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Clemastine 100 pg/ml Plasma GC/MS Clenbuterol 0.2 ng/ml Plasma / Urine GC/MS Clindamycin 100 ng/ml Plasma LC/MS/MS Clonazepam 100 pg/ml Plasma LC/MS/MS Clonidine 25 pg/ml Plasma GC/MS Clozapine 0.1 ng/ml Plasma LC/MS/MS Codeine 1 ng/ml Plasma LC/MS/MS Cortisol 1 Ng/ml Plasma LC/MS/MS Cyclobenzaprine 0.1 ng/ml Plasma LC/MS/MS Cyclosporin 10 ng/ml Whole Blood LC/MS/MS Cyproterone Acetate 25 pg/ml Plasma/Serum GC/MS Desmopressin 2.5 pg/ml Plasma LC/MS/MS Desogestrel (3-keto-desogestrel) 25 pg/ml Plasma GC/MS Desogestrel (3-keto-desogestrel) /Ethinylestradiol 25/2.5 pg/ml Plasma GC/MS Dexamethasone 0.25 ng/ml Plasma LC/MS/MS Diclofenac 5 ng/ml Plasma LC/MS/MS Dienogest 0.5 ng/ml Plasma LC/MS/MS Digoxin 1 ng/ml Urine LC/MS/MS Digoxin 1 ng/ml Plasma LC/MS/MS Diltiazem / Desmethyldiltiazem / Desacetyldiltiazem 4/2/1 ng/ml Plasma LC/MS/MS Diph enydramine 1 ng/ml Plasma LC/MS/MS Disulfiram (as Methyl Diethydithiocarbamate) 1.0 ng/ml Plasma GC/MS Docetaxel 2.5 ng/ml Plasma LC/MS/MS Doxorubicin 1.5 ng/ml Urine LC/MS/MS Doxorubicin / Doxorubicinol 0.5 / 0.5 ng/ml Plasma LC/MS/MS Doxycycline 0.1 ng/ml Plasma LC/MS/MS Dronabinol/11-OH-Dronabinol 200/200 pg/ml Plasma LC/MS/MS Drospirenone 100 pg/ml Plasma LC/MS/MS Dydrogesterone 50 pg/ml Plasma GC/MS Enalapril & Enalaprilat 250 pg/ml Plasma LC/MS/MS Eprosartan 1 ng/ml Plasma LC/MS/MS Ergotamine 25 pg/ml Plasma LC/MS/MS Estradiol / Estrone 5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 2.5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 1 / 2 pg/ml Serum GC/MS Estradiol / Estrone 50 / 100 pg/ml Rat Plasma/Serum GC/MS Estriol 10.0 pg/ml Plasma/Serum GC/MS Free Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 5/5/2.5/2.5 pg/ml Plasma GC/MS Total Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 50/50/10/10 pg/ml Plasma GC/MS Estrone Sulfate 50 pg/ml Plasma LC/MS/MS Estrone Sulfate 50 pg/ml Plasma GC/MS EthinylEstradiol 1 pg/ml Plasma GC/MS Ethinylestradiol 2.5 pg/ml Plasma GC/MS Ethinylestradiol / Norethindrone 2.5 / 25 pg/ml Plasma GC/MS Ethinylestradiol / Norgestrel (levonorgestrel) 10 / 50 pg/ml Serum GC/MS Etoposide 0.5 ng/ml Plasma LC/MS/MS Exemestane 50 pg/ml Plasma LC/MS/MS Famotidine 2 ng/ ml Plasma LC/MS/MS Felodipine 50 pg/ml Plasma GC/MS Felodipine 25 ng/ml Plasma LC/MS/MS Fenofibric Acid 10 ng/ml Plasma LC/MS/MS Fentanyl 25 pg/ml Plasma LC/MS/MS LABORATORY SERVICES Bioanalytical Methods BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Finasteride 0.5 ng/ml Plasma LC/MS/MS Flavoxate / MFCA metabolite 0.1/50 ng/ml Plasma LC/MS/MS/HPLC UV Fludrocortisone 25 pg/ml Plasma GC/MS Flunisolide 50 pg/ml Plasma GC/MS Fluspirilene 25 pg/ml Plasma GC/MS Flutamide / Hydroxyflutamide 20/2 pg/ml Plasma GC/MS Fluticasone/Salmeterol 2.5 pg/ml Plasma LC/MS/MS Fluvoxamine 200 pg/ml Plasma LC/MS/MS Fosinoprilat 5 ng/ml Plasma LC/MS/MS Fur nidipine 25 pg/ml Plasma GC/MS Furosemide 50 ng/ml Plasma LC/MS/MS Gabapentin 50 ng/ml Plasma LC/MS Gadolinium 1μg/ml Serum/Urine ICP/MS Gemfibrozil 200 ng/ml Plasma LC/MS/M Gliclazide 5 ng/ml Plasma LC/MS/MS Glimepiride 1 ng/ml Serum LC/MS/MS Glycopyronium 1.0 pg/ml Plasma LC/MS/MS Goserelin 0.2 ng/ml Plasma LC/MS/MS Guaifenesin 2.5 ng/ml Plasma LC/MS/MS Haloperidol 25 pg/ml Plasma LC/MS/MS Homocysteine 5μg/ml Plasma LC/MS/MS Hydrocodone 0.25 ng/ml Plasma LC/MS/MS Hydromorphone 20.0 pg/ml Plasma LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4- 10 ng/ml Plasma/Saliva LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4- 0.1 μg/ml Urine LC/MS/MS Hydroxymidazolam, a / Hydroxymidazolam, 4- 2 / 2 ng/ml Plasma LC/MS/MS 2-Hydroxypropyl-beta-cyclodextrin 0.1 μg/ml Plasma LC/MS Hyoscyamine 50 pg/ml Plasma GC/MS Ibuprofen 0.25 μg/ml Plasma LC/MS/MS Ibuprofen R- / S- 0.25 μg/ml Plasma LC/MS/MS Iloprost 10 pg/ml Plasma LC/MS/MS Imipramine / Desipramine 0.10 ng/ml Plasma LC/MS/MS Indapamide 0.5 ng/ml Plasma LC/MS/MS Indomethacin 20 ng/ml Plasma LC/MS/MS Interferon alpha 10 pg/ml Serum ELISA Iodine 0.5/5 μg/ml Whole Blood/Urine ICP/MS Irbesartan 5 ng/ml Plasma LC/MS/MS Isosorbide Dinitrate 0.1 ng/ml Plasma GC/MS Isosorbide-2-mononitrate 0.25 ng/ml Plasma GC/MS Isosorbide-5-mononitrate 0.25 ng/ml Plasma GC/MS Is otretinoin / 4-Oxo-Isotretinoin 10 ng/ml Plasma LC/MS/MS Isradapine 100 pg/ml Plasma LC/MS/MS Ketoprofen 1 ng/ml Plasma LC/MS/MS Ketoprofen 50 ng/ml Urine GC/MS Ketotifen 25 pg/ml Plasma GC/MS Lacidipine 20 pg/ml Plasma LC/MS/MS Lamotrigine 10 ng/ml Plasma LC/MS/MS Lercanidipine R- & S- 20 pg/ml Plasma LC/MS/MS Letrozole 10 ng/ml Plasma LC/MS/MS Leuprolide 0.04 ng/ml Plasma EIA Levofloxacin 0.2 μg/ml Plasma LC/MS/MS Levonorgestrel 10 pg/ml Plasma/Serum GC/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services One of the largest inventories of validated bioanalytical assays. BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Lisinopril 1 ng/ml Plasma LC/MS/MS Lisuride 10 pg/ml Plasma LC/MS/MS Lithium 25 ng/ml Serum ICP/MS Loperamide 125 pg/ml Plasma GC/MS Loratadine / Descarboethoxyloratadine 100/50 pg/ml Plasma GC/MS Lorazepam 1.0 ng/ml Plasma LC/MS/MS Lynestrenol 0.1 ng/ml Plasma GC/MS Medrogestone 50 pg/ml Plasma GC/MS Medroxyprogesterone Acetate 0.1 ng/ml Plasma/Serum GC/MS Megesterol Acetate 100 pg/ml Plasma GC/MS Melatonin 5 pg/ml Plasma LC/MS/MS Meloxicam 10 ng/ml Plasma LC/MS/MS Melperone 0.25 ng/ml Plasma GC/MS Memantine 100 pg/ml Plasma GC/MS Mephenytoin (R,S) Phenotyping Urine GC/MS R-Mephenytoin / S-Mephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 0.1 μg/ml Urine LC/MS/MS R-Mephenytoin / S-Mephenytoin 0.1 μg/ml Urine LC/MS/MS Metformin 10 ng/ml Plasma LC/MS/MS Methamphetamine 100 pg/ml Plasma/Serum GC/MS Methoxyestradiol/Methoxyestrone 5 pg/ml Plasma GC/MS Methylnicotinamide 10 ng/ml Plasma LC/MS/MS Methylphenidate 100 pg/ml Plasma LC/MS/MS Methylprednisolone 0.5 ng/ml Plasma LC/MS/MS Methyltestosterone 50 pg/ml Plasma GC/MS Metoprolol 1.00 ng/ml Plasma LC/MS/MS Midazolam 0.5 ng/ml Plasma GC/MS-LC/MS Minocycline 0.27 ng/ml Plasma LC/MS/MS Mirtazapine 0.5 ng/ml Plasma GC/MS Misoprostol Acid 10 pg/ml Serum LC/MS/MS Moexipril 1 ng/ml Plasma LC/MS/MS Molindone 250 pg/ml Plasma LC/MS/MS Morphine / Morphine-3-glucuronide / Morpine-6-glucuronide 0.5/5/2 ng/ml Plasma LC/MS/MS Moxonidine 0.05/1 ng/ml Plasma/Urine GC/MS Mycophenolic Acid / Mycophenolic Acid Glucuronide 0.1/0.5 ug/ml Dog Plasma LC/MS/MS Niacin (Nicotinic Acid) / Nicotinuric acid 25 ng/ml Plasma LC/MS/MS Nicardipine 25 pg/ml Plasma GC/MS Nico randil 1 ng/ml Plasma GC/MS Nicotinamide 10 ng/ml Plasma LC/MS/MS Nicotine / Cotinine 0.5/2.5 ng/ml Plasma GC/MS Nilvadipine 50 pg/ml Plasma GC/MS R-Nirvanol / S-Nirvanol 20 ng/ml Plasma/Saliva LC/MS/MS R-Nirvanol / S-Nirvanol 0.25 μg/ml Urine LC/MS/MS Nitisonon 1 ng/ml Plasma LC/MS/MS Nitrendipine
Load more

Recommended publications
  • Properties and Units in Clinical Pharmacology and Toxicology
    Pure Appl. Chem., Vol. 72, No. 3, pp. 479–552, 2000. © 2000 IUPAC INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE SCIENTIFIC DIVISION COMMITTEE ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)# and INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY CHEMISTRY AND HUMAN HEALTH DIVISION CLINICAL CHEMISTRY SECTION COMMISSION ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)§ PROPERTIES AND UNITS IN THE CLINICAL LABORATORY SCIENCES PART XII. PROPERTIES AND UNITS IN CLINICAL PHARMACOLOGY AND TOXICOLOGY (Technical Report) (IFCC–IUPAC 1999) Prepared for publication by HENRIK OLESEN1, DAVID COWAN2, RAFAEL DE LA TORRE3 , IVAN BRUUNSHUUS1, MORTEN ROHDE1, and DESMOND KENNY4 1Office of Laboratory Informatics, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 2Drug Control Centre, London University, King’s College, London, UK; 3IMIM, Dr. Aiguader 80, Barcelona, Spain; 4Dept. of Clinical Biochemistry, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland #§The combined Memberships of the Committee and the Commission (C-NPU) during the preparation of this report (1994–1996) were as follows: Chairman: H. Olesen (Denmark, 1989–1995); D. Kenny (Ireland, 1996); Members: X. Fuentes-Arderiu (Spain, 1991–1997); J. G. Hill (Canada, 1987–1997); D. Kenny (Ireland, 1994–1997); H. Olesen (Denmark, 1985–1995); P. L. Storring (UK, 1989–1995); P. Soares de Araujo (Brazil, 1994–1997); R. Dybkær (Denmark, 1996–1997); C. McDonald (USA, 1996–1997). Please forward comments to: H. Olesen, Office of Laboratory Informatics 76-6-1, Copenhagen University Hospital (Rigshospitalet), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. E-mail: [email protected] Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible.
    [Show full text]
  • Screening of 300 Drugs in Blood Utilizing Second Generation
    Forensic Screening of 300 Drugs in Blood Utilizing Exactive Plus High-Resolution Accurate Mass Spectrometer and ExactFinder Software Kristine Van Natta, Marta Kozak, Xiang He Forensic Toxicology use Only Drugs analyzed Compound Compound Compound Atazanavir Efavirenz Pyrilamine Chlorpropamide Haloperidol Tolbutamide 1-(3-Chlorophenyl)piperazine Des(2-hydroxyethyl)opipramol Pentazocine Atenolol EMDP Quinidine Chlorprothixene Hydrocodone Tramadol 10-hydroxycarbazepine Desalkylflurazepam Perimetazine Atropine Ephedrine Quinine Cilazapril Hydromorphone Trazodone 5-(p-Methylphenyl)-5-phenylhydantoin Desipramine Phenacetin Benperidol Escitalopram Quinupramine Cinchonine Hydroquinine Triazolam 6-Acetylcodeine Desmethylcitalopram Phenazone Benzoylecgonine Esmolol Ranitidine Cinnarizine Hydroxychloroquine Trifluoperazine Bepridil Estazolam Reserpine 6-Monoacetylmorphine Desmethylcitalopram Phencyclidine Cisapride HydroxyItraconazole Trifluperidol Betaxolol Ethyl Loflazepate Risperidone 7(2,3dihydroxypropyl)Theophylline Desmethylclozapine Phenylbutazone Clenbuterol Hydroxyzine Triflupromazine Bezafibrate Ethylamphetamine Ritonavir 7-Aminoclonazepam Desmethyldoxepin Pholcodine Clobazam Ibogaine Trihexyphenidyl Biperiden Etifoxine Ropivacaine 7-Aminoflunitrazepam Desmethylmirtazapine Pimozide Clofibrate Imatinib Trimeprazine Bisoprolol Etodolac Rufinamide 9-hydroxy-risperidone Desmethylnefopam Pindolol Clomethiazole Imipramine Trimetazidine Bromazepam Felbamate Secobarbital Clomipramine Indalpine Trimethoprim Acepromazine Desmethyltramadol Pipamperone
    [Show full text]
  • Clinical and Forensic Toxicology Proficiency Testing (EQA) Catalogue 2011/2012 Contents
    Clinical and forensic toxicology proficiency testing (EQA) catalogue 2011/2012 Contents Introduction • Promoting excellence through 3 proficiency testing • Aim of proficiency testing 3 • Quality standards 3 • Benefits of proficiency testing 4 • Who should participate in 4 proficiency testing schemes? • Who participates in LGC Standards 4 proficiency testing schemes? • Why choose LGC Standards as 4 your proficiency testing provider? • Why do I need proficiency testing? 4 • PT/EQA schemes for clinical and 5 forensic toxicology • Benefits of participation in 5 HEATHCONTROL PT/EQA schemes Clinical and forensic PT schemes • HEATHCONTROL – Therapeutic 6 Drug Monitoring (TDM) • HEATHCONTROL – Toxicology (TOX) 8 • HEATHCONTROL – Drugs of Abuse 9 in Urine (DAU) • HEATHCONTROL – Drugs in Oral 10 Fluid (DOF) • QUARTZ – Forensic blood 11 toxicology scheme • FORENSICS PT trial scheme 12 • Confidentiality 13 • Reports 13 • Other PT services 13 • Product development 13 • Reference materials 14 • Summary 14 Tel: +44 (0)161 762 2500 Fax: +44 (0)161 762 2501 Introduction LGC Standards Aim of proficiency testing Promoting excellence through Proficiency testing is defined in ISO/IEC 17043 proficiency testing as the evaluation of participant performance LGC Standards is an accredited international against pre-established criteria by means of provider of proficiency testing (PT) services interlaboratory comparisons. The terms “External also known as External Quality Assessment Quality Assessment or EQA” are often used for (EQA). We have over twenty five years proficiency testing in the medical/clinical area. experience in all aspects of providing PT services LGC Standards Proficiency Testing provides to laboratories undertaking clinical, chemical, a wide range of schemes designed to improve microbiological, and physical measurements.
    [Show full text]
  • Manage the Triad of Depression, Anxiety & Chronic Pain
    For the Use of a Registered Medical Practitioner or a Hospital or a Laboratory Only Manage the Triad of Depression, Anxiety & Chronic Pain • Reduces anxiety & depressive symptoms from day 41 • Reduces pain reception by blocking NMDA receptors2 INDPRT173558 22 DEC 2017 Ref: 1. Ramakrishnan K, et al. Clinical experience with dothiepin in an Indian population. J Drug Dev 1991;4(3):151-159. 2. Huizinga M. Painful Diabetic Neuropathy: A Management-Centered Review. Clin Diabet 2007;25(1):6-25. Abbreviated Prescribing Information Dosulepin Tablets BP (Formerly Dothiepin tablets BP) PROTHIADENTM COMPOSITION Each film coated tablet contains Dosulepin Hydrochloride B.P. 25 mg Each film coated tablet contains Dosulepin Hydrochloride B.P. 75 mg INDICATION For the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. For the treatment of chronic pain. DOSAGE AND ADMINISTRATION Depression: 25 to 50 mg three times daily or 75 to 150 mg as a single dose at night. Chronic Pain: 50 to 150mg once a day orally CONTRAINDICATIONS Recent myocardial infarction, any degree of heart block or other cardiac arrhythmias, for the treatment of mania, for patients with severe liver disease, for patients with known hypersensitivity to Dosulepin hydrochloride or any of the excipients. WARNINGS & PRECAUTIONS Suicide/suicidal thoughts or clinical worsening, Avoid use in patients with a history of epilepsy, thyroid disease, mania or urinary retention and in those with narrow-angle glaucoma or symptoms suggestive of prostatic hypertrophy.
    [Show full text]
  • Prothiaden 25Mg & 75Mg (Front) Size: 222 X 252Mm Colour: Black Date: 01-04-2014, 13-08-2014, 18-09-2014, 09-06-2015, 11-06-2015 Ammara Commercial Printers (Pvt.) Ltd
    d te a Lactation trimester of pregnancy have also been reported (see o Dosulepin/metabolites are excreted in human milk. Breast- PREGNANCY AND LACTATION). C m For the information of Medical Profession feeding should be discontinued during treatment with Dosulepin. il Class effects F EFFECTS ON ABILITY TO DRIVE AND USE MACHINES Epidemiological studies, mainly conducted in patients 50 years of PROTHIADEN Initially, Dosulepin may impair alertness; therefore Dosulepin has age and older, show an increased risk of bone fractures in patients minor influence on the ability to drive and use machines. receiving SSRIs and TCAs. The mechanism leading to this risk is (Dosulepin Hydrochloride) unknown. ADVERSE REACTIONS The following adverse effects, although not necessarily all OVERDOSAGE reported with Dosulepin, have occurred with other tricyclic Symptoms: PRODUCT DESCRIPTION antidepressants. Deaths may occur from overdosage with this class of drugs. Dosulepin hydrochloride is a tricyclic antidepressant that has Multiple drug ingestion (including alcohol) is common in deliberate anxiolytic properties. The chemical name is 3-(6H-dibenzo(b,e)- Blood and lymphatic system disorders tricyclic antidepressant overdose. Onset of toxicity occurs within thiepin-11-ylidene) propyldimethylamine hydrochloride. Bone marrow depression, agranulocytosis 4-6 hours after tricyclic antidepressant overdose. Dosulepin hydrochloride is a white to faintly yellow crystalline Symptoms of overdose include dry mouth, excitement, ataxia, powder that is almost without odor. The compound is soluble in Immune system disorder drowsiness,unconsciousness, muscle twitching, convulsions, water, chloroform, and alcohol but is almost insoluble in ether. The Hypersensitivity reactions widely dilated pupils, hyperreflexia, sinus tachycardia, cardiac molecular weight is 331.9. arrhythmias, hypotension, hypothermia, depression of respiration, visual hallucinations, delirium, urinary retention, Endocrine disorders Inactive Ingredients paralytic ileus, and respiratory or metabolic alkalosis.
    [Show full text]
  • DOTHEP Dosulepin (Dothiepin) Hydrochloride Tablet and Capsules
    AUSTRALIAN PRODUCT INFORMATION DOTHEP dosulepin (dothiepin) hydrochloride tablet and capsules 1. NAME OF THE MEDICINE Dosulepin (dothiepin) hydrochloride 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains 25 mg of dosulepin (dothiepin) hydrochloride as the active ingredient. Each tablet contains 75 mg of dosulepin (dothiepin) hydrochloride as the active ingredient. Dothep 25 capsules contain lactose as well as sulfites (present in trace amounts). Dothep 75 tablets contain lactose as well as sulfites and soya bean products (sulfites and soya bean are present in trace amounts). 3. PHARMACEUTICAL FORM DOTHEP 25: 25 mg capsule: size 4 hard capsule with green body and red cap. DOTHEP 75: 75 mg tablet: red film-coated tablet, normal convex, marked “DT/75” on one side, “α” on reverse. Dothiepin hydrochloride is a white or faintly yellow, crystalline powder. It is freely soluble in water, in alcohol and in methylene chloride. The partition coefficient (log p) for dothiepin hydrochloride is 4.98 and the pKa is 9.76. 4. CLINICAL PARTICULARS 4.1. THERAPEUTIC INDICATIONS For the treatment of major depression. The 75 mg tablet is indicated only for the maintenance treatment of major depression (see Section 4.4. Special Warning and Precautions for Use). 4.2. DOSE AND METHOD OF ADMINISTRATION The main dose should be taken at night as it may produce drowsiness. Note. Dosage should be reduced to the smallest amount necessary to maintain relief of the symptoms of depression, once a satisfactory response has been obtained. Plasma levels will reach a new steady state 10 to 14 days after each up or down adjustment.
    [Show full text]
  • Screening of 300 Drugs in Blood Utilizing Second Generation
    Screening of 300 Drugs in Blood Utilizing Second Generation Exactive Plus High-Resolution, Accurate Mass Spectrometer and ExactFinder Software Kristine Van Natta, Marta Kozak, Xiang He Thermo Fisher Scientific, San Jose, CA FIGURE 2. Schematic diagram of the Exactive Plus high-resolution accurate FIGURE 5. ExactFinder processing method and database. FIGURE 7. LODs for around 490 compounds For targeted screening, ExactFinder uses parameters set in processing method to Overview mass benchtop mass spectrometer. identify and confirm the presence of compound based on database values. Figure 8 Purpose: Evaluate Thermo Scientific Exactive Plus high performance bench-top mass Compound LOD Compound LOD Compound LOD Compound LOD shows data review results for one donor sample. In this method, compounds were 1‐(3‐Chlorophenyl)piperazine 5 Deacetyl Diltiazem 5 Lormetazepam 5 Perimetazine 5 identified by accurate mass within 5 ppm and retention time. Identity was further spectrometer for drug screening of whole blood for forensic toxicology purposes. 10‐hydroxycarbazepine 5 Demexiptiline 5 Loxapine 5 Phenacetin 5 5‐(p‐Methylphenyl)‐5‐phenylhydantoin 10 Des(2‐hydroxyethyl)opipramol 5 LSD 5 Phenazone 5 confirmed by isotopic pattern and presence of known fragments. Methods: Whole blood samples were processed by precipitation with ZnSO / 6‐Acetylcodeine 100 Desalkylflurazepam 5 Maprotiline 5 Pheniramine 5 4 6‐Methylthiopurine 5 Desipramine 5 Maraviroc 5 Phenobarbital 5 Matrix effects were observed to be compound dependent and were generally within methanol. Samples were injected onto an HPLC under gradient conditions and 6‐Monoacetylmorphine 5 Desmethylcitalopram 5 MBDB 5 Phenylbutazone 5 7(2,3dihydroxypropyl)Theophylline 5 Desmethylclozapine 50 MDEA 5 Phenytoin 10 ±50%.
    [Show full text]
  • Summary of Product Characteristics
    Irish Medicines Board Summary of Product Characteristics 1 NAME OF THE MEDICINAL PRODUCT Dothep 75 mg Film -coated Tablets 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 75 mg Dosulepin Hydrochloride (Dothiepin Hydrochloride). Excipient: Each tablet contains 115 mg Lactose monohydrate and 1.75 mg Ponceau 4R (E124) For a full list of excipient, see section 6.1. 3 PHARMACEUTICAL FORM Film -coated tablet Red film -coated 8.5 mm normal convex tablets embossed DN/75 on one side and G on the other. 4 CLINICAL PARTICULARS 4.1 Therapeutic Indications Dothep tablets are indicated in the treatment of symptoms of depressive illness, in particular, where an anti -anxiety effect is required. 4.2 Posology and method of administration Dothep tablets are administered orally. Recommended dosage schedules: Adults : Initially 75 mg/day in divided doses (as capsules) or as a single dose at night, increasing to 150 mg/day. In certain circumstances, e.g. in hospital use, dosages up to 225 mg daily have been used. Suggested dosage regimen: 25 to 50 mg three times daily or, alternatively, 75 or 150 mg as a single dose at night. Elderly : 50 – 75 mg daily initially. As with any antidepressant, the initial dose should be increased with caution under close supervision. Half the normal adult dose may be sufficient to produce a satisfactory clinical response. Children : Not recommended. 4.3 Contraindications Dothep tablets are contra -indicated in patients with: Closed angle glaucoma, existing urinary retention, recent myocardial infarction, any degree of heart block or other cardiac arrhythmia ’s, acute psychoses, severe liver disease, women who are breast -feeding, or patients currently receiving monoamine oxidase inhibitors, or have received these within the previous two weeks.
    [Show full text]
  • Toxicology Solutions
    Toxicology Solutions Contents Introduction 06 Biochip Array Technology 08 Introduction 07 Overview 10 Our Team 07 Testing Process 11 Customisable Test Menu 12 Evidence Range of Analysers 13 Test Menu 16 Evidence Evolution 22 Evidence Evolution Specifications 24 Evidence 26 Evidence Specifications 28 Evidence MultiSTAT 30 Evidence MultiSTAT Specifications 32 Evidence Investigator 34 Evidence Investigator Specifications 36 ELISA 38 Quality Control 54 Test Menu 40 Controls and Calibrators 56 Clinical Chemistry 42 Index - Cross Reactivity 58 Test Menu 44 DoA 1 60 RX daytona+ 46 DoA 1+ 62 RX daytona+ Specifications 48 DoA II 64 RX imola 50 DoA III 66 RX imola Specifications 52 DoA IV 67 DoA V 69 DoA ULTRA / DUID 72 6 7 Introduction Pioneering solutions for accurate drug detection Randox Toxicology aim to minimise laboratory workflow constraints whilst maximising the scope of quality drug detection. We are the primary manufacturer of Biochip Array Technology, ELISAs, Homogeneous EIA, Quality Control and automated systems for forensic, clinical and workplace toxicology. Our Team At the core of our business is our research and development team, who lead the way in developing new tests from our UK Headquarters. Our global technical and engineering support means that no matter where your laboratory is in the world, we can guarantee a rapid response to our customers needs. With 19 patents granted and 17 pending, significant re-investment into research and development has allowed us to introduce novel tests and pioneering technology to the market. With the ability to raise antibodies and develop assays in-house, we can produce the optimum target compounds with excellent specificity.
    [Show full text]
  • Metabolism and Pharmacokinetics of Dothiepin
    Br. J. clin. Pharmac. (1981), 12, 405-409 METABOLISM AND PHARMACOKINETICS OF DOTHIEPIN K.P. MAGUIRE, G.D. BURROWS, T.R. NORMAN & B.A. SCOGGINS' Department of Psychiatry and 'Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia. 1 Seven healthy volunteers received a single oral dose of 75 mg dothiepin. Plasma concentrations of dothiepin were measured by gas chromatography-mass fragmentography. 2 The plasma concentrations obtained were fitted to the equation C, = Ae a(t T) + Be d 7) - Ce ka(t-TI. The mean peak concentration was 47(33-71) ,ug/l at 3(2-5) h. Mean estimates were as follows: absorption half life 1.2(0.07-3.0) h, distribution half-life 2.6(1.1-3.8) h, elimination half-life 22(14-40) h, apparent volume of distribution 45(20-92) 1/kg, and oral clearance 1.36(0.88-1.8)1 kg-' h-'. 3 Blood concentrations of dothiepin were measured in comparison in five of the volunteers. The mean blood/plasma ratio was 0.7(0.6-0.8). , 4 Plasma and blood concentrations of northiaden and blood concentrations of dothiepin S-oxide, two metabolites of dothiepin, were also measured. Dothiepin S-oxide was the major metabolite reaching a peak level of 81(34-150) ,ug/l at 5(4-6) h. In comparison, northiaden reached a peak concentration of only 10 (3-21) ,g/l at 5 (4-9) h. The mean half-life of elimination of dothiepin S-oxide was 19 (13-35) h while that for northiaden was 33 (22-60) h.
    [Show full text]
  • Antidepressants in Pregnancy and Breastfeeding
    Antidepressants in pregnancy and breastfeeding Anne Sved Williams, Psychiatrist, Clinical Senior Lecturer, University of Adelaide, and Director, Perinatal and Infant Mental Health Services, Children, Youth and Women's Health Services, South Australia Summary have increased rates of behavioural problems and learning difficulties by the age of five years.3 Maternal depression and anxiety during pregnancy and the early years of an infant's life Lactation cause substantial problems to the mother, her The relationship between postnatal depression and infant and her family. Suicide is an ever-present breastfeeding is emerging as complex. Women who develop risk with depression along with adverse effects postnatal depression are more likely to stop breastfeeding than women who are not depressed. Likewise, women who establish on infant growth and birth weight. Balancing and maintain breastfeeding are less likely to develop depression these risks against accumulating evidence of the than women who have difficulties with breastfeeding. effects of selective serotonin reuptake inhibitors on the fetus and infant presents a challenge to Harmful effects of antidepressants the treating doctor. Careful explanation to the Antidepressant use in Australia has changed in the last two woman and her partner of the risks of both the decades. Tricyclic antidepressants have fallen from favour and condition and the treatment, using a biological, many have been withdrawn. Their adverse effects and risk of fatality from overdose make them hazardous. However, psychological and social treatment approach, is some doctors continue to prescribe them after considering likely to provide the most benefit. the risks and the benefits. There have been few documented Key words: depression, infants, lactation, selective serotonin problems arising from their use, but this is perhaps due to lack reuptake inhibitors.
    [Show full text]
  • TDM – Therapeutic Drugs Monitoring Proficiency Scheme
    TDM – Therapeutic drugs monitoring proficiency scheme Therapeutic drug monitoring (TDM) range may result in a high or low serum is a measurement of specific drug concentration if not monitored and concentration levels at timed intervals controlled. in patients, usually through blood/ ISO 15189 requires that medical laboratories serum samples, and is necessary seek confirmation for confidence in their results where control of drug concentrations through participation in suitable proficiency testing is required to achieve optimum programmes (PT) or external quality assurance (EQA). Accreditation bodies consider participation treatment for the patient. For most in PT/EQA an important tool for demonstrating the drugs, monitoring is not required as technical competence of the laboratory. they have a wide therapeutic index. However, drugs with narrow therapeutic LGC Quality - ISO/IEC17043 • ISO9001 Scheme operation The main TDM scheme year operates from January to December and test materials are despatched three rounds at a time four times per annum. Round despatch dates and reporting deadlines are available on the current TDM application form, and further information can be found in the TDM scheme description. These documents can be downloaded from our website www.lgcstandards.com Test material Analytes Therapeutic drugs mixture Lyophilised human Caffeine, Carbamazepine, Carbamazepine+CBZ-epoxide, CBZ-epoxide, Clonazepam, Digoxin, Ethosuximide, serum Lamotrigine, Lithium, Methotrexate, Phenobarbitone, Phenytoin, Primidone, TD- Amikacin, TD-Gentamicin,
    [Show full text]