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TDM Therapeutic Drugs Monitoring lgcstandards.com/AXIO ISO/IEC 17043 | ISO/IEC 17025 | ISO 9001 TDM Therapeutic Drugs Monitoring The LGC AXIO Therapeutic Drugs The operation of the LGC AXIO TDM Monitoring (TDM) proficiency testing scheme is supported by an Advisory scheme provides independent Group consisting of members of the performance assessment for the routine professional bodies, scheme quantification of a wide range of anti- participants, and others experienced in epileptic and other therapeutic drugs. the field. The scheme reports on the performance of U.K. participants (who TDM is a measurement of specific drug have clinical responsibilities) to the concentration levels at timed intervals in National Quality Assurance Advisory patients, usually through blood/serum Panels for Chemical Pathology. samples, and is necessary where control of drug concentrations is required to achieve optimum treatment for the patient, or where there is a narrow range between the therapeutic and toxic levels. TDM Therapeutic Drug Monitoring Test Material* Analyte* Therapeutic drug Carbamazepine; CBZ-epoxide; Carbamazepine+CBZ-epoxide; Clonazepam; mixture Lamotrigine; Phenytoin; Ethosuximide; Phenobarbitone; Primidone; Valproate; (lyphilised Caffeine; Digoxin; Lithium; Theophylline; Methotrexate; TD-Amikacin; TD- human serum) Gentamicin; Clobazam, Norclobazam. TD-Tobramycin; TD-Vancomycin. Anti-epileptic Brivaracetam, Felbamate, Gabapentin, Lacosamide, Levetiracetam, OH- drugs (lyophilised oxcarbazepine, Pregabalin, Perampanel, Retigabine (Ezogabine), Rufinamide, human serum) Tiagabine, Topiramate, Vigabatrin, Zonisamide. Cardiac drugs Amiodarone, Desethylamiodarone, Flecainide. (lyophilised human serum) Analgesic mixture Diclofenac, Ibuprofen, Tramadol. (lyophilised human serum) Substance abuse Buprenorphine, EDDP, Methadone, Norbuprenorphine. & treatment (lyophilised human serum) Psychoactive Amisulpride, Amitriptyline/Nortriptyline, Aripiprazole/Dehydroaripiprazole, drugs (lyophilised Citalopram/Norcitalopram, Clomipramine/Norclomipramine, Clozapine/ human serum, Norclozapine, Doxepin/Nordoxepin, Dothiepin/Northiaden, Duloxetine, new born calf Escitalopram, Fluphenazine, Fluvoxamine, Haloperidol, Imipramine/Desipramine, serum) Fluoxetine/Norfluoxetine, Maprotiline/Normaprotiline, Mianserin, Mirtazapine/ Normirtazapine, Olanzapine, Paroxetine, Perphenazine, Quetiapine/Norquetiapine, Risperidone/HO-risperidone, Sertraline/ Norsertraline, Sulpiride, Thioridazine, Trazodone, Trimipramine/Nortrimipramine, Venlafaxine/ Norvenlafaxine, Ziprasidone, Zuclopenthixol. Brexpiprazole, Lurasidone, Sertindole, Iloperidone. Psychostimulants Atomoxetine, Methylphenidate. Ritalinic Acid. (lyophilised human serum) Non-smoking Cotinine, Nicotine. compliance (lyophilised human serum) Antibiotics and Amikacin, Gentamicin, Teicoplanin, Tobramycin, Vancomycin, Antibiotics, Antifungals (liquid Antifungals. human serum) Anti-hypertensive Drug identification. drugs (urine) * The full range and availability of test materials and analytes is determined on an annual basis and may be added or removed. For accredited and non-accredited status please see current application form/scheme description. Find out more at lgcstandards.com/axio.

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Properties and Units in Clinical Pharmacology and Toxicology
Pure Appl. Chem., Vol. 72, No. 3, pp. 479–552, 2000. © 2000 IUPAC INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE SCIENTIFIC DIVISION COMMITTEE ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)# and INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY CHEMISTRY AND HUMAN HEALTH DIVISION CLINICAL CHEMISTRY SECTION COMMISSION ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)§ PROPERTIES AND UNITS IN THE CLINICAL LABORATORY SCIENCES PART XII. PROPERTIES AND UNITS IN CLINICAL PHARMACOLOGY AND TOXICOLOGY (Technical Report) (IFCC–IUPAC 1999) Prepared for publication by HENRIK OLESEN1, DAVID COWAN2, RAFAEL DE LA TORRE3 , IVAN BRUUNSHUUS1, MORTEN ROHDE1, and DESMOND KENNY4 1Office of Laboratory Informatics, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 2Drug Control Centre, London University, King’s College, London, UK; 3IMIM, Dr. Aiguader 80, Barcelona, Spain; 4Dept. of Clinical Biochemistry, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland #§The combined Memberships of the Committee and the Commission (C-NPU) during the preparation of this report (1994–1996) were as follows: Chairman: H. Olesen (Denmark, 1989–1995); D. Kenny (Ireland, 1996); Members: X. Fuentes-Arderiu (Spain, 1991–1997); J. G. Hill (Canada, 1987–1997); D. Kenny (Ireland, 1994–1997); H. Olesen (Denmark, 1985–1995); P. L. Storring (UK, 1989–1995); P. Soares de Araujo (Brazil, 1994–1997); R. Dybkær (Denmark, 1996–1997); C. McDonald (USA, 1996–1997). Please forward comments to: H. Olesen, Office of Laboratory Informatics 76-6-1, Copenhagen University Hospital (Rigshospitalet), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. E-mail: [email protected] Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible.
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Clinical and Forensic Toxicology Proficiency Testing (EQA) Catalogue 2011/2012 Contents
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d te a Lactation trimester of pregnancy have also been reported (see o Dosulepin/metabolites are excreted in human milk. Breast- PREGNANCY AND LACTATION). C m For the information of Medical Profession feeding should be discontinued during treatment with Dosulepin. il Class effects F EFFECTS ON ABILITY TO DRIVE AND USE MACHINES Epidemiological studies, mainly conducted in patients 50 years of PROTHIADEN Initially, Dosulepin may impair alertness; therefore Dosulepin has age and older, show an increased risk of bone fractures in patients minor influence on the ability to drive and use machines. receiving SSRIs and TCAs. The mechanism leading to this risk is (Dosulepin Hydrochloride) unknown. ADVERSE REACTIONS The following adverse effects, although not necessarily all OVERDOSAGE reported with Dosulepin, have occurred with other tricyclic Symptoms: PRODUCT DESCRIPTION antidepressants. Deaths may occur from overdosage with this class of drugs. Dosulepin hydrochloride is a tricyclic antidepressant that has Multiple drug ingestion (including alcohol) is common in deliberate anxiolytic properties. The chemical name is 3-(6H-dibenzo(b,e)- Blood and lymphatic system disorders tricyclic antidepressant overdose. Onset of toxicity occurs within thiepin-11-ylidene) propyldimethylamine hydrochloride. Bone marrow depression, agranulocytosis 4-6 hours after tricyclic antidepressant overdose. Dosulepin hydrochloride is a white to faintly yellow crystalline Symptoms of overdose include dry mouth, excitement, ataxia, powder that is almost without odor. The compound is soluble in Immune system disorder drowsiness,unconsciousness, muscle twitching, convulsions, water, chloroform, and alcohol but is almost insoluble in ether. The Hypersensitivity reactions widely dilated pupils, hyperreflexia, sinus tachycardia, cardiac molecular weight is 331.9. arrhythmias, hypotension, hypothermia, depression of respiration, visual hallucinations, delirium, urinary retention, Endocrine disorders Inactive Ingredients paralytic ileus, and respiratory or metabolic alkalosis.
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DOTHEP Dosulepin (Dothiepin) Hydrochloride Tablet and Capsules
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