LABORATORY SERVICES BioanalyticalOur resources become yours.Methods [email protected] www.nuvisan.com NUVISAN ® Pharma Services LABORATORY SERVICES Bioanalytical Methods BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Acetaminophen 0.25 μg/ml Plasma LC/MS/MS Acetaminophen/Tramadol 100 / 5 ng/ml Plasma LC/MS/MS Albuterol 0.5 ng/ml Plasma GC/MS Aldosterone 25 pg/ml Serum ELISA Alendronate 1 / 0.5 ng/ml Urine/Plasma LC/MS/MS Alkaline Hematin (Menstrual Blood) 3 ml Feminine Hygeine Prod. Colorimetric Allopurinol / Oxypurinol 50 /100 ng/ml Plasma LC/MS/MS Alprazolam 50 pg/ml Plasma GC/MS Alprazolam 0.5 ng/ml Plasma LC/MS/MS Aluminum 5/2 ng/ml Plasma/Urine ICP/MS Amikacin 0.15 ug/ml Serum LC/MS/MS 5-Aminosalicylic acid/N-acetyl-5-aminosalicylic acid 10/20 ng/ml Plasma LC/MS/MS Amiodarone / Desethylamiodarone 10 / 10 ng/ml Plasma LC/MS/MS Amitriptyline 200 pg/ml Plasma LC/MS/MS Amlodipine 50 pg/ml Plasma LC/MS/MS Amphetamine 100 pg/ml Plasma/Serum GC/MS Articaine 10 ng/ml Plasma/Urine GC/MS Articainic Acid 20 ng/ml Plasma/Urine GC/MS Atenolol 10 ng/ml Plasma LC/MS/MS Atenolol 250 ng/ml Urine LC/MS/MS Atorvastatin/O-hydroxy/P-hydroxy atorvastatin 200/100/20 pg/ml Plasma LC/MS/MS Atropine 50 pg/ml Plasma GC/MS Atomoxetine 10 ng/ml Plasma LC/MS/MS Azathioprine/6-Mercaptopurine 1/1 ng/ml Plasma LC/MS/MS Azithromycin 2 ng/ml Plasma LC/MS/MS Benazepril / Benazeprilat 5 / 10 ng/ml Plasma LC/MS/MS Benidipine 50 pg/ml Plasma GC/MS Betahistine 5 pg/ml Plasma LC/MS/MS Betamethasone 50 pg/ml Plasma GC/MS B icalutamide 2.5 ng/ml Plasma LC/MS/MS Biperiden 250 pg/ml Plasma GC/MS Bismuth 0.5 ng/ml Plasma ICP-MS Bisoprolol 0.2 ng/ml Plasma LC/MS/MS Boswellic Acid 50 ng/ml Plasma GC/MS Bromine 0.5 μg/ml Plasma ICP/MS Bromocriptine 2.5 pg/ml Plasma LC/MS/MS Brompheniramine 0.5 ng/ml Plasma LC/MS/MS Budesonide/16-OH Budesonide/16-OH Prednisolone 0.1/0.1/0.5 ng/ml Plasma LC/MS/MS Buprenorphine 25 pg/ml Plasma GC/MS Buprenorphine / Norbuprenorphine 5 / 5 pg/ ml Plasma LC/MS/MS Buspirone / 1-PP 100 pg/ml Plasma LC/MS/MS Butorphanol 20 pg/ml Plasma LC/MS/MS Canrenone 2 ng/ml Plasma LC/MS/MS Canrenone 20 ng/ml Urine LC/MS/MS Capric Acid 100 ng/ml Plasma LC/MS/MS Carvedilol 0.1 ng/ml Plasma LC/MS/MS Cetirizine 2 ng/ml Plasma LC/MS/MS Chlorhexidine 25 ng/ml Saliva LC/MS/MS Chlormadinone Acetate 50 pg/ml Plasma GC/MS Citalopram 100 pg/ml Plasma LC/MS/MS Citric Acid 50 ng/ml Urine LC/MS/MS Clarithromycin 10 ng/ml Plasma LC/MS/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services Our recources become yours. BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Clemastine 100 pg/ml Plasma GC/MS Clenbuterol 0.2 ng/ml Plasma / Urine GC/MS Clindamycin 100 ng/ml Plasma LC/MS/MS Clonazepam 100 pg/ml Plasma LC/MS/MS Clonidine 25 pg/ml Plasma GC/MS Clozapine 0.1 ng/ml Plasma LC/MS/MS Codeine 1 ng/ml Plasma LC/MS/MS Cortisol 1 Ng/ml Plasma LC/MS/MS Cyclobenzaprine 0.1 ng/ml Plasma LC/MS/MS Cyclosporin 10 ng/ml Whole Blood LC/MS/MS Cyproterone Acetate 25 pg/ml Plasma/Serum GC/MS Desmopressin 2.5 pg/ml Plasma LC/MS/MS Desogestrel (3-keto-desogestrel) 25 pg/ml Plasma GC/MS Desogestrel (3-keto-desogestrel) /Ethinylestradiol 25/2.5 pg/ml Plasma GC/MS Dexamethasone 0.25 ng/ml Plasma LC/MS/MS Diclofenac 5 ng/ml Plasma LC/MS/MS Dienogest 0.5 ng/ml Plasma LC/MS/MS Digoxin 1 ng/ml Urine LC/MS/MS Digoxin 1 ng/ml Plasma LC/MS/MS Diltiazem / Desmethyldiltiazem / Desacetyldiltiazem 4/2/1 ng/ml Plasma LC/MS/MS Diph enydramine 1 ng/ml Plasma LC/MS/MS Disulfiram (as Methyl Diethydithiocarbamate) 1.0 ng/ml Plasma GC/MS Docetaxel 2.5 ng/ml Plasma LC/MS/MS Doxorubicin 1.5 ng/ml Urine LC/MS/MS Doxorubicin / Doxorubicinol 0.5 / 0.5 ng/ml Plasma LC/MS/MS Doxycycline 0.1 ng/ml Plasma LC/MS/MS Dronabinol/11-OH-Dronabinol 200/200 pg/ml Plasma LC/MS/MS Drospirenone 100 pg/ml Plasma LC/MS/MS Dydrogesterone 50 pg/ml Plasma GC/MS Enalapril & Enalaprilat 250 pg/ml Plasma LC/MS/MS Eprosartan 1 ng/ml Plasma LC/MS/MS Ergotamine 25 pg/ml Plasma LC/MS/MS Estradiol / Estrone 5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 2.5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 1 / 2 pg/ml Serum GC/MS Estradiol / Estrone 50 / 100 pg/ml Rat Plasma/Serum GC/MS Estriol 10.0 pg/ml Plasma/Serum GC/MS Free Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 5/5/2.5/2.5 pg/ml Plasma GC/MS Total Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 50/50/10/10 pg/ml Plasma GC/MS Estrone Sulfate 50 pg/ml Plasma LC/MS/MS Estrone Sulfate 50 pg/ml Plasma GC/MS EthinylEstradiol 1 pg/ml Plasma GC/MS Ethinylestradiol 2.5 pg/ml Plasma GC/MS Ethinylestradiol / Norethindrone 2.5 / 25 pg/ml Plasma GC/MS Ethinylestradiol / Norgestrel (levonorgestrel) 10 / 50 pg/ml Serum GC/MS Etoposide 0.5 ng/ml Plasma LC/MS/MS Exemestane 50 pg/ml Plasma LC/MS/MS Famotidine 2 ng/ ml Plasma LC/MS/MS Felodipine 50 pg/ml Plasma GC/MS Felodipine 25 ng/ml Plasma LC/MS/MS Fenofibric Acid 10 ng/ml Plasma LC/MS/MS Fentanyl 25 pg/ml Plasma LC/MS/MS LABORATORY SERVICES Bioanalytical Methods BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Finasteride 0.5 ng/ml Plasma LC/MS/MS Flavoxate / MFCA metabolite 0.1/50 ng/ml Plasma LC/MS/MS/HPLC UV Fludrocortisone 25 pg/ml Plasma GC/MS Flunisolide 50 pg/ml Plasma GC/MS Fluspirilene 25 pg/ml Plasma GC/MS Flutamide / Hydroxyflutamide 20/2 pg/ml Plasma GC/MS Fluticasone/Salmeterol 2.5 pg/ml Plasma LC/MS/MS Fluvoxamine 200 pg/ml Plasma LC/MS/MS Fosinoprilat 5 ng/ml Plasma LC/MS/MS Fur nidipine 25 pg/ml Plasma GC/MS Furosemide 50 ng/ml Plasma LC/MS/MS Gabapentin 50 ng/ml Plasma LC/MS Gadolinium 1μg/ml Serum/Urine ICP/MS Gemfibrozil 200 ng/ml Plasma LC/MS/M Gliclazide 5 ng/ml Plasma LC/MS/MS Glimepiride 1 ng/ml Serum LC/MS/MS Glycopyronium 1.0 pg/ml Plasma LC/MS/MS Goserelin 0.2 ng/ml Plasma LC/MS/MS Guaifenesin 2.5 ng/ml Plasma LC/MS/MS Haloperidol 25 pg/ml Plasma LC/MS/MS Homocysteine 5μg/ml Plasma LC/MS/MS Hydrocodone 0.25 ng/ml Plasma LC/MS/MS Hydromorphone 20.0 pg/ml Plasma LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4- 10 ng/ml Plasma/Saliva LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4- 0.1 μg/ml Urine LC/MS/MS Hydroxymidazolam, a / Hydroxymidazolam, 4- 2 / 2 ng/ml Plasma LC/MS/MS 2-Hydroxypropyl-beta-cyclodextrin 0.1 μg/ml Plasma LC/MS Hyoscyamine 50 pg/ml Plasma GC/MS Ibuprofen 0.25 μg/ml Plasma LC/MS/MS Ibuprofen R- / S- 0.25 μg/ml Plasma LC/MS/MS Iloprost 10 pg/ml Plasma LC/MS/MS Imipramine / Desipramine 0.10 ng/ml Plasma LC/MS/MS Indapamide 0.5 ng/ml Plasma LC/MS/MS Indomethacin 20 ng/ml Plasma LC/MS/MS Interferon alpha 10 pg/ml Serum ELISA Iodine 0.5/5 μg/ml Whole Blood/Urine ICP/MS Irbesartan 5 ng/ml Plasma LC/MS/MS Isosorbide Dinitrate 0.1 ng/ml Plasma GC/MS Isosorbide-2-mononitrate 0.25 ng/ml Plasma GC/MS Isosorbide-5-mononitrate 0.25 ng/ml Plasma GC/MS Is otretinoin / 4-Oxo-Isotretinoin 10 ng/ml Plasma LC/MS/MS Isradapine 100 pg/ml Plasma LC/MS/MS Ketoprofen 1 ng/ml Plasma LC/MS/MS Ketoprofen 50 ng/ml Urine GC/MS Ketotifen 25 pg/ml Plasma GC/MS Lacidipine 20 pg/ml Plasma LC/MS/MS Lamotrigine 10 ng/ml Plasma LC/MS/MS Lercanidipine R- & S- 20 pg/ml Plasma LC/MS/MS Letrozole 10 ng/ml Plasma LC/MS/MS Leuprolide 0.04 ng/ml Plasma EIA Levofloxacin 0.2 μg/ml Plasma LC/MS/MS Levonorgestrel 10 pg/ml Plasma/Serum GC/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown. NUVISAN ® Pharma Services One of the largest inventories of validated bioanalytical assays. BIOANALYTICAL METHODS Analyte(s) LLOQ Units Matrix Methodology Lisinopril 1 ng/ml Plasma LC/MS/MS Lisuride 10 pg/ml Plasma LC/MS/MS Lithium 25 ng/ml Serum ICP/MS Loperamide 125 pg/ml Plasma GC/MS Loratadine / Descarboethoxyloratadine 100/50 pg/ml Plasma GC/MS Lorazepam 1.0 ng/ml Plasma LC/MS/MS Lynestrenol 0.1 ng/ml Plasma GC/MS Medrogestone 50 pg/ml Plasma GC/MS Medroxyprogesterone Acetate 0.1 ng/ml Plasma/Serum GC/MS Megesterol Acetate 100 pg/ml Plasma GC/MS Melatonin 5 pg/ml Plasma LC/MS/MS Meloxicam 10 ng/ml Plasma LC/MS/MS Melperone 0.25 ng/ml Plasma GC/MS Memantine 100 pg/ml Plasma GC/MS Mephenytoin (R,S) Phenotyping Urine GC/MS R-Mephenytoin / S-Mephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 0.1 μg/ml Urine LC/MS/MS R-Mephenytoin / S-Mephenytoin 0.1 μg/ml Urine LC/MS/MS Metformin 10 ng/ml Plasma LC/MS/MS Methamphetamine 100 pg/ml Plasma/Serum GC/MS Methoxyestradiol/Methoxyestrone 5 pg/ml Plasma GC/MS Methylnicotinamide 10 ng/ml Plasma LC/MS/MS Methylphenidate 100 pg/ml Plasma LC/MS/MS Methylprednisolone 0.5 ng/ml Plasma LC/MS/MS Methyltestosterone 50 pg/ml Plasma GC/MS Metoprolol 1.00 ng/ml Plasma LC/MS/MS Midazolam 0.5 ng/ml Plasma GC/MS-LC/MS Minocycline 0.27 ng/ml Plasma LC/MS/MS Mirtazapine 0.5 ng/ml Plasma GC/MS Misoprostol Acid 10 pg/ml Serum LC/MS/MS Moexipril 1 ng/ml Plasma LC/MS/MS Molindone 250 pg/ml Plasma LC/MS/MS Morphine / Morphine-3-glucuronide / Morpine-6-glucuronide 0.5/5/2 ng/ml Plasma LC/MS/MS Moxonidine 0.05/1 ng/ml Plasma/Urine GC/MS Mycophenolic Acid / Mycophenolic Acid Glucuronide 0.1/0.5 ug/ml Dog Plasma LC/MS/MS Niacin (Nicotinic Acid) / Nicotinuric acid 25 ng/ml Plasma LC/MS/MS Nicardipine 25 pg/ml Plasma GC/MS Nico randil 1 ng/ml Plasma GC/MS Nicotinamide 10 ng/ml Plasma LC/MS/MS Nicotine / Cotinine 0.5/2.5 ng/ml Plasma GC/MS Nilvadipine 50 pg/ml Plasma GC/MS R-Nirvanol / S-Nirvanol 20 ng/ml Plasma/Saliva LC/MS/MS R-Nirvanol / S-Nirvanol 0.25 μg/ml Urine LC/MS/MS Nitisonon 1 ng/ml Plasma LC/MS/MS Nitrendipine