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[email protected] [email protected] AM09389PU-S Monoclonal Antibody to AKR1C1 / DHH1 (1-323) - Purified Alternate names: 2-dihydrobenzene-1, 2-diol dehydrogenase, 20-alpha-hydroxysteroid dehydrogenase, Aldo-keto reductase family 1 member C1, Chlordecone reductase homolog HAKRC, Dihydrodiol dehydrogenase 1/2, High-affinity hepatic bile acid-binding protein, Trans-1 Quantity: 50 µl Concentration: 1.0 mg/ml Background: The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone to the less potent efficiencies. AKR1C1 and AKR1C3 also act as 3-ketosteroid reductase, and as such they can convert the most potent androgen 5alpha-DHT into 3beta- andorstandiol, which is an estrogen receptor beta ligand, and into the inactive androgen 3alpha-androstnionl, respectively. Uniprot ID: Q04828 NCBI: NP_001344 GeneID: 1645 Host / Isotype: Mouse / IgG1 Recommended Isotype SM10P (for use in human samples), AM03095PU-N Controls: Clone: AT6D10 Immunogen: Recombinant Human AKR1C1 (1-323aa) purified from E. coli Format: State: Liquid purified Ig fraction Purification: Affinity Chromatography on Protein G Buffer System: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol Applications: ELISA. Western blot: 1/1000. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Immunocytochemistry / Immunoflourescence. Flow cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.