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148 Izutsu, K., Fujimaki, Y., Kuwabara, A. and Aoyagi, N.: Effect of Counterions on the Physical Properties of L- Arginine in Fr

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148 Izutsu, K., Fujimaki, Y., Kuwabara, A. and Aoyagi, N.: Effect of Counterions on the Physical Properties of L- Arginine in Fr 148 国 立 衛 研 報 第124号（2006） 誌 上 発 表（原著論文） Summaries of Papers Published in Other Journals (Original Papers) Izutsu, K., Fujimaki, Y., Kuwabara, A. and Aoyagi, N.: 檜山行雄：品質に関するトピックの動向－Q9－ Effect of counterions on the physical properties of L- 医薬品研究，37（2），131-139（2006）． arginine in frozen solutions and freeze-dried solids. Keywords: ICH, risk management, pharmaceutical quality Int. J. Pharm., 301, 161-169 (2005). Keywords: freeze-drying, molecular interaction, Tagawa, H.＊, Kizuka, Y.＊, Ikeda, T.＊, Itoh, S., Kawasaki, amorphous, formulation N., Kurihara, H.＊, Onozato, H.＊, Tojo, A.＊, Sakai, T.＊, Kawasaki, T.＊ and Oka, S.＊: A non-sulfated from of the Izutsu, K., Fujimaki, Y., Kuwabara, A., Hiyama, Y., NHK-1 carbohydrate is specifically expressed in mouse Yomota, C. and Aoyagi, N.: Near-infrared analysis of kidney. protein secondary structure in aqueous solutions and J. Biol. Chem., 280, 23876-23883 (2005). freeze-dried solids. Keywords: HNK-1, glucuronyltransferases, CD13/ J. Pharm. Sci., 95, 781-789 (2006). aminopeptidase N Keywords: freeze-drying, secondary structure, near- ＊京都大学大学院 infrared spectroscopy, protein formulation Hirano, M.＊, Ma, B. Y.＊, Kawasaki, N., Okimura, K.＊, Yoshioka, S., Aso, Y. and Miyazaki, T.: Negligible Baba, M.＊, Nakagawa, T.＊, Miwa, K.＊, Kawasaki, N.＊, contribution of molecular mobility to the degradation Oka, S.＊ and Kawasaki, T.＊: Mannan-binding (and rate of insulin lyophilized with poly(vinylpyrrolidone). (protein blocks the activation of metalloproteases J. Pharm. Sci., 95, 939-643 (2006). meprin. Keywords: solid state stability, glass transition, molecular J. Immunol., 175, 3177-3185 (2005). mobility Keywords: meprin, mannan-binding protein, MBP ligands ＊京都大学大学院 Yoshioka, S. and Aso, Y.: Comparison of the glass transition temperature and fragility parameter of Hashii, N., Kawasaki, N., Itoh, S., Hyuga, M., isomalto-olygomer predicted by molecular dynamics Kawanishi, T. and Hayakawa, T.: Glycomic/ simulations with those measured by differential scanning glycoproteomic analysis by LC/MS: Analysis of glycan calorimetry. structural alternation in the cells. Chem. Pharm. Bull., 53, 1443-1445 (2005). Proteomics, 5, 4665-4672 (2005). Keywords: molecular dynamics simulation, glass transition, Keywords: LC/MS, N-acetylglucosaminyltransferase III, fragility oligosaccharide Yoshioka, S. and Aso, Y.: A quantitative assessment of Itoh, S., Kawasaki, N., Harazono, A., Hashii, N., Matsuishi, the significance of molecular mobility as a determinant Y., Kawanishi, T. and Hayakawa, T.: Characterization of for the stability of lyophilized insulin formulations. a gel-separated unknown glycoprotein by liquid Pharm. Res., 22, 1358-1364 (2005). chromatography/ multiple tandem mass spectrometry. Keywords: molecular mobility, glass transition temperature, Analysis of rat brain Thy-1 separated by sodium insulin dodecyl sulfate-polyacrylamide gel electrophoresis. J. Chromatogr. A, 1094, 105-1017 (2005). Aso, Y. and Yoshioka, S: Molecular Mobility of Nifedipine- Keywords: LC/MS, SDS-PAGE, Thy-1 PVP and Phenobarbital-PVP Solid Dispersions as Measured by 13C-NMR Spin-Lattice Relaxation Time. Itoh, S., Kawasaki, N., Hashii, N., Harazono, A., J. Pharm. Sci., 95, 318-325 (2006). Matsuishi, Y., Hayakawa, T. and Kawanishi, T.: N-linked Keywords: Spin-lattice relaxation time, Solid dispersion, oligosaccharide analysis by liquid chromatography with Stability graphitized carbon column/ liner ion trap-Fourier transform ion cyclotron resonance mass spectrometry in 小山靖人，檜山行雄：医薬品製剤 GMP ガイドライン－ positive and negative ion modes. これからの GMP のあるべき姿と国際調和 J. Chromatogr. A, 1103, 296-306 (2006). PHARMA TECH JAPAN, 21, 1365-1376 (2005). Keywords: LC/MS, FT-ICR-MS, Thy-1 Keywords: GMP, guideline, pharmaceutical quality Harazono, A., Kawasaki, N., Itoh, S., Hashii, N., Ishii- 檜山行雄，坂本知昭：GMP をめぐる動向について Watabe, A., Kawanish, T. and Hayakawa, T: Site-specific 医薬品研究，37（1），42-56（2006）． N-glycosylation analysis of human plasma cerulopasmin Keywords: pharmaceutical quality, GMP, ICH using liquid chromatography/ electrospry ionization tandem mass spectrometry. 誌 上 発 表（原著論文） 149 Anal. Biochem., 348, 259-268 (2006). Ebizuka, Y.＊ and Goda, Y.: Inhibition of human Keywords: LC/MS, ceruloplasmin, site-specific glycosylation lanosterol synthase by constituents of Laurus nobilis L. analysis Journal of Natural Medicines, 60, 78-81 (2006). Keywords: Laurus nobilis, lanosterol synthase inhibition, Hashii, N., Kawasaki, N., Itoh, S., Harazono, A., bay leaf Matsuishi, Y., Hayakawa, T. and Kawanishi, T.: Specific ＊東大院薬 detection of Lewis x-carbohydrates in biological samples using liquid chromatography/multiple-stage tandem Shoji, T.＊, Masumoto, S.＊, Moriichi, N.＊, Akiyama, H., mass spectrometry. Kanda, T.＊, Ohtake, Y.＊, Goda, Y.: Apple procyanidin Rapid commun. Mass spectrom., 19, 3315-3321 (2005). oligomers absorption in rats after oral administration: Keywords: LC/MS, Lewis x, oligosaccharide analysis of procyanidins in plasma using the Porter method and high-performance liquid chromatography/ Niimi, S., Harashima, M.＊, Takayama, K.＊, Hara, M.＊, tandem mass spectrometry. Hyuga, M., Seki, T.＊, Ariga, T.＊, Kawanishi, T. and J. Agric. Food Chem., 54, 884-892 (2005). Hayakawa, T.: Thrombomodulin enhances the invasive Keywords: absorption, apple procyanaidins, HPLC/MS/ activity of mouse mammary tumor cells. MS J. Biochem., 137, 579-586 (2005). ＊アサヒビール基盤研究所 Keywords: thrombomodulin, thrombin, invasion ＊日本大学生物資源科学部 Tanaka, R.＊, Morimoto, T.＊, Nakamura, M.＊ and Goda, Y.: Component determination and specification of a 後藤洋子＊，新見伸吾：ラクトース修飾絹フィブロイ food additives, “Methyl Hesperidin”. ン基材上の初代培養ラット肝細胞の形態および機能に Japanese Journal of Food Chemistry, 12, 71-75 (2005). 及ぼすインスリンとデキサメタゾンの作用 Keywords: hesperidin, hesperetin, flavonoid 高分子論文集（Kobunshi Ronbunshu），62（7），326- ＊三栄源FFI 330（2005）. Keywords: Lactose-Silk Fibroin conjugates, Rat hepatocytes, Uchiyama, N., Kim, I. H., Kawahara, N. and Goda, Y.: Morphology HPLC separation of hesperidin and the C-2 epimer in ＊農業生物資源研究所 commercial hesperidin samples and herbal medicines. Chirality, 17, 373-377 (2005). Kumagai, Y.＊, Hyuga, S.＊, Hyuga, M., Watanabe, K.＊, Keywords: hesperidin, diastereomer separation, online Kawanishi, T. and Hanawa, T.＊: Estrogen-like activity CD detection in Kampo medicines used for menopausal symptoms and gynecological diseases. Sato, M.＊, Anetai, M.＊ and Goda, Y.: Oraganophosphorus J. Trad. Med., 22, 228-236 (2005). pesticide residues in decoctions of crude drugs. Keywords: estrogen, menopausal symptoms, gynecological Iyakuhin Kenkyu, 37, 245-250 (2006). diseases Keywords: organophosphorus pesticide residues, ＊北里研究所東洋医学総合研究所 decoction, Kampo extracts ＊北海道立衛生研究所 Tanaka, H.＊, Namekata, I.＊, Takeda, K.＊, Kazama, A.＊, Shimizu, Y.＊, Moriwaki, R.＊, Hirayama, W.＊, Sato, A.＊, Kinoshita, T.＊, Haga, Y.＊, Narimatsu, S.＊, Shimada, M.＊ Kawanishi, T. and Shigenobu, K.＊: Unique excitation - and Goda, Y.: The isolation and structure elucidation of contraction characteristics of mouse myocardium as new cassane diterpene-acids from Caesalpinia crista L. revealed by SEA0400, a specific inhibitor of Na+-Ca2+ (Fabaceae), and review on nomenclature of some exchanger. Caesalpinia species. Naunyn Schmiedebergs Arch. Pharmacol., 371, 526-534 Chem Pharm. Bull., 53, 717-720 (2005). (2005). Keywords: Caesalpinia crista, Fabaceae, cassane diterpene Keywords: sodium, calcium, myocardium ＊帝京大学薬学部 ＊東邦大学薬学部 Yamamoto, K.＊, Yamamoto, T.＊, Kondo, S.＊, Tamura, Kawanishi, T.: Regulatory perspectives from Japan - M.＊, Shibata, Y.＊, Umeda, K.＊, Akiba, S.＊, Kawakami, comparability of biopharmaceuticals. T.＊, Saito, F.＊, Sugimoto, T.＊, Nakashima, Y.＊, Biologicals, 34, 65-68 (2006). Tahara, M., Hayashi, K.＊, Sudo, M.＊, Nakanishi, K.＊, Keywords: regulation, biopharmaceuticals, comparability Isozaki, O.＊, Kawahara, N. and Goda, Y.: Assay of ginsenoside Rg1 and ginsenoside Rb1 in Ginseng and Red Tanaka, R., Sakano, Y.＊, Shimizu, K., Shibuya, M.＊, Ginseng by high-performance liquid chromatography. 150 国 立 衛 研 報 第124号（2006） Iyakuhin Kenkyu, 36, 211-222 (2005). Kuroyanagi, M.＊1, Shimomae, M.＊1, Nagashima, Y.＊1, Keywords: ginsenoside quantification method, Japanese Muto, N.＊1, Okuda, T.＊1, Kawahara, N., Nakane, T.＊2 Pharmacopoeia, validation data and Sano, T.＊3: New Diarylheptanoids from Alnus ＊日本漢方生薬製剤協会 japonica and Their Antioxidative Activity. Chem. Pharm. Bull., 53 (12), 1519-1523 (2005). Saito, K.＊, Toyo'oka, T.＊, Kato, M.＊, Fukushima, T.＊, Keywords: Alnus japonica, Betulaceae, diarylheptanoid Shirota, O. and Goda, Y.: Determination of psilocybin in ＊1 広島県立大学 hallucinogenic mushrooms by reversed-phase liquid ＊2 昭和薬科大学 chromatography with fluorescence detection. ＊3 広島県林業センター Talanta, 66, 562-568 (2005). ＊静岡県立大学薬学部 Kim, I-H., Kaneko, N., Uchiyama, N., Lee, J-E.＊, Takeya, K.＊, Kawahara, N. and Goda, Y.: Two phenylpropanoid Sasaki, N.＊, Abe, Y.＊, Wada, K.＊, Koda, T.＊, Goda, Y., glycosides from Neopicrorhiza scrophulariiflora. Adachi, T.＊ and Ozeki, Y.＊: Amaranthin in geather Chem. Pharm. Bull., 54 (2), 275-277 (2006). cockscombs is synthesized via glucuronylation at the Keywords: Neopicrorhiza scrophulariiflora, Scrophularia- cyclo-DOPA glucoside step in the betacyanin biosynthetic ceae, phenylpropanoid glycoside pathway. ＊東京薬科大学 J. Plant Res., 118, 439-442 (2005). Keywords: amaranthin, betacyanin biosynthetic pahway, Otsuki, T.＊1, Sato, M.＊1, Kayano, T.＊2, Kowithayakorn, cyclo-DOPA glucoside step T.＊3, Kawahara, N., Goda, Y. and Ishibashi, M.＊1: ＊東京農工大学工学部生命工学科 Steroidal saponins from Calamus insignis, and their cell growth and cell cycle inhibitory activities. Anjiki,
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