Subject Index
Total Page：16
File Type：pdf, Size：1020Kb
Subject Index A Ascending reticular activating system statistical properties, 407 (ARAS), 40 study results, 410 Aanat (arylalkylamine N-acetyltransferase Aschoff’s Rule, 2, 36, 334 Bipolar disorder. See Clock and bipolar mRNA), 148 ASD (advanced sleep disorders), 42–43, disorder AC (adenylyl cyclase), 88 98, 100 bizarre, 235 Acetabularia,59 Asperger syndrome, 645 Black-box experimental designs, 2 Acomys sp. (spiny mice), 616 ASPS (advanced sleep phase syndrome), Blind free-runners (BFRs), 626–628 ACTR, 107 274, 630 Blindness and biological clock, 42–43, 294, Adenosinergic system, 574 AtGenExpress, 353 583, 586, 623–624, 626–628 Adenylyl cyclase (AC), 88 AtGRP7, 147–148 Blue light photoreceptor, 63, 119–121. Adrenal gland and SCN, 553–554 ATPase activity of KaiC, 50–52 See also Structure and function Advanced sleep disorders (ASD), 42–43, Autism spectrum disorders (ASD) of animal cryptochromes 98, 100 atypical sleep and circadian rhythms, Blue light responses, 16–17, 119–121 Advanced sleep phase syndrome (ASPS), 649–650 BLUF, 123–124 274, 630 atypical synapses, 647–648 BMAL1 (brain and muscle ARNT-like Affymetrix ATH1 GeneChip data sets, 354 background, 645 protein). See also Aftereffect, 2 circadian rhythms and, 648 CLOCK/BMAL1 After hours (Afh), 86–87 clock genes and, 648–649 acetylation by CLOCK, 108 Age and circadian clock in humans, 295 genetic causes of, 645–646 circadian rhythmicity and acetylation Aging and circadian rhythms. See Clock melatonin treatment in, 648–649, 650 of, 109–110 proteins, aging, and pathways involved, 650–651 clock and cellular proliferation tumorigenesis; RNAi screen to study conclusions, 651–652 interactions, 468 identify longevity genes synaptic genes and, 646–647 FEO and (see Food-entrainable Aging and disease. See Sirtuins in aging AVP (arginine vasopressin), 26, 529, 530 oscillator) and disease in mammals, 12–14 Agomelatine, 638, 640 B in mice, 85–87, 254–258 ′ 5 -AMP as a mediator of procolipase negative feedback loop and, 414 expression, 288–289 Bacterial circadian programs role in premature aging, 478–479 Andante (And), 218 adaptive significance of circadian specificity of acetylation by CLOCK, Animal cryptochrome. See Structure and timing, 397–398 108–109 function of animal cell division vs. circadian oscillators, Bmal1 gene cryptochromes 397 impact of retina-specific deletion on Apis mellifera (honeybee), 615 circadian orchestration of global gene clock function, 312–315 Apnea, 590 expression, 396–397 retinal, and circadian rhythm Arabidopsis thaliana discovery of circadian clocks in responses, 315–316 AtGRP7, 147–148 bacteria, 395–396 retinal electrical activity in response to blue light photoreceptor research, mechanism and evolution/ecology light, 311–312 16–17, 119–121 study, 402–403 retinal gene expression rhythms and, CRY1 and CRY2 interactions, 125–126 structural biology of clock proteins, 310–311 cryptochrome photocycle, 127 398–399 Body temperature (Tb), 607. See also cryptochromes, 134–135 validity of TTFL model, 399–400 Hibernation F-box proteins in, 258 in vitro clockwork, 400 Bombyx mori (silkworm), 434 flowering pathway, 17 in vitro oscillator modeling, 400–402 Borbély-Daan model, 41–42 input, 16–17 band (bd), 204–205 Botany Array Resource, 353 microarray data analysis (see Basal forebrain (BF), 40 Brain and muscle ARNT-like protein. See DIURNAL project) Bats (Hipposideros speoris), 616 BMAL1 mRNA levels in, 15–16 Beavers (Castor canadensis), 615 Breast cancer, 462 oscillator, 15–16 Benzer, Seymour, 75 Bright-light therapy, 638 output, 17 BFRs (blind free-runners), 626–628 Bulla gouldiana,22 phosphorylation in, 197–198 Bioluminescence model Bünning, Erwin, 1 photoentrainment in, 194–195 background to studies, 405–406 Butterflies’ circadian clock. See Time- ARAS (ascending reticular activating balance of stability, coupling, and compensated sun compass system), 40 noise, 406 orientation Arctocephalinae,38 coculture experiment, 408–409 Butyrate response factor (BRF1), 163 Arcuate nucleus (Arc), 30–31 correspondence between phase and Arginase and Period 2 gene, 101 rate equation models, 409–410 C Arginine vasopressin (AVP), 26, 529, 530 envelope analysis, 408 Arginine vasopressin mRNA poly(A) interaction of phase oscillators, Caenorhabditis elegans length, 146 407–408 anti-aging genes in (see Sirtuins in ArrayExpress, 353 intercellular coupling, 406 aging and disease) Arrhythmicity, 29 mathematics of phase model, 406–407 longevity genes identification (see Arylalkylamine N-acetyltransferase observation of self-sustained RNAi screen to identify mRNA (Aanat), 148 oscillators, 406 longevity genes) 663 664 SUBJECT INDEX Calbindin (CalB), 529, 532, 533 circadian-cancer connection and, cell cycle and, 459–460 Calcium/calmodulin-dependent protein 461–462 chromatin remodeling and, 461–462 kinase (CAMK), 14–17 enzymatic function of CLOCK, DNA-damage response and, 460–461 Calcium ions (Ca2+) and hibernation, 107–108 hormones and, 462 607–608, 611 histone acetyltransferase activity and, CIRCADIAN CLOCK ASSOCIATED 1 Calorie restriction (CR), 483. See also 105–106 (CCA1), 15–16 Sirtuins in aging and disease peripheral vs. central clocks, 106–107 Circadian clockwork of mice Calretinin, 529 plasticity in circadian regulation and, circadian organization and cAMP response element–binding (CREB) 107 synchronization, 91–93 protein, 24 specificity of BMAL1 acetylation by entrainment in Vipr2–/– mice, 89–90 Cancer biology and therapeutics CLOCK, 108–109 neuropeptide signaling and circadian chronotherapeutics and, 472–473 Chronic jet lag (CJL), 467–469 synchronization, 87–89 circadian gating of cell division, Chronobiology phase shifts of liver clockwork, 89–90 465–466 central molecular loops and, 656 Prok2 signaling and circadian output circadian rhythms and (see Circadian- circadian defined, 1 control by SCN, 90–91 cancer connection) circadian organization modeling, 658 proteasomal degradation and circadian clinical studies, 466–467 circadian rhythmicity in cyanobacteria, period, 85–87 clock and cellular proliferation 656 question of clock period setting, 86 interactions, 468–469 circadian rhythmicity in eukaryotes, transcriptional cascades related to clock proteins and (see Clock proteins, 656 protein expressions, 92 aging, and tumorigenesis) clock concept, 4 Circadian gene expression regulation in down-regulation of tumor growth by clocks distribution within multicellular the liver circadian timing system, 466 organisms, 657 background to studies, 319–320 model of timing system and tumor of cohabitation (see Chronobiology of feeding/fasting cycles as zeitgeber proliferation interactions, cohabitation) oscillators, 320–321 471–472 historical perspective, 655–656 signaling pathways, 324, 327–328 Period 2 gene and, 100 historical time line, 1–2 signals impacting synchronization of tumor growth rate experiments, 467 humans as experimental subjects, fibroblast oscillators, 321–322 tumorigenesis (see Clock proteins, 658–659 study conclusions and perspectives, aging, and tumorigenesis) increase in understanding of 328 CAR (constitutive androstane receptor), mechanisms, 655–656 systemically and oscillator-driven 390 interaction of sleep and circadian genes, 323–324, 325–326 Cardiovascular system and Period 2 gene, rhythms, 657–658 transgenic mouse model of system- 101 limitations to mice studies, 657 and oscillator-driven genes, Casein kinase (CK) 1 and 2 links between central and peripheral 322–323 in A. thaliana,16 clocks, 657 Circadian input kinase (CikA) protein, 8, biology of tau mutation and (see tau long time constant of circadian clock, 334–335 mutation in hamsters) 62 Circadian photoreception in vertebrates CK1 role in N. crassa clock (see mutations in humans, 658 background to research, 499 CK1a-dependent phase shifting and phase response, 3–4 contribution of the eyes to circadian phosphorylation of N. crassa) properties of a circadian rhythm, 3 entrainment, 501 in Drosophila clock model (see social costs of fatigue, 659 contribution of the eyes to free- Molecular clock in Symposium synopsis, 655–659 running period changes, Drosophila) temperature-compensation, 4 501–502 human circadian clock and (see terminology and methods, 2–3 evidence of extraretinal photoreceptors Genetics of human clocks) Chronobiology of cohabitation in sparrows, 500 phosphorylation in Drosophila and, cohousing and changes in τ values, eyes and LL-induced arrhythmicity, 168–174 616–618 502 temperature-compensation and, 65–67 focus of research, 618–619 lack of eye involvement in Casein kinase 2 (CK2), 70 studies distinguishing individual photoperiodic photoreception, Castor canadensis (beavers), 615 activity under social 502 Catastrophes theory, 445 conditions, 615–616 location of extraretinal photoreceptors Cavia porcellus (guinea pigs), 38 study conclusions, 619–620 in sparrows, 500–501 CCA1 (CIRCADIAN CLOCK temporal coupling between hamsters, mammalian photoentrainment, ASSOCIATED 1), 15–16 616 502–503 Ccgs. See Clock-controlled genes Chronogenetics rod pathways and control of temporal CDD (childhood disintegrative disorder), disconnected gene, 216–217 niche, 503, 505 645 genetic background related to clock rods and ipRGC interactions, 503, 504 Cellular redox state, prokaryotic systems, outputs, 221–225 study conclusions, 505–506 8–10 implications of genotypic variants of Circadian rhythms Cetaceans and sleep, 38 per, 225–229 aging and (see Clock proteins, aging, Chemotherapy and circadian clock, 413. inputs to Drosophila pacemaker, and tumorigenesis) See also Cancer biology and 219–221 ASD and, 648, 649–650