NATURE MEDAL AWARDS of the ROYAL Society*

No. 3762, DECEMBER 6, 1941 NATURE 699 MEDAL AWARDS OF THE ROYAL SOCIEtY* CoPLEY MEDAL the experiments of still more recent series have dealt HE Copley Medal has been awarded to Sir with pain and functional defects in muscles and T Thomas Lewis. nerves, due to interruption of the blood supply. Lewis's life's work, still in vigorous progress but Apart from the separate accounts of items and stages for interruption by war duties and war conditions, of these lines of research, as completed, in papers has been the application of precise and controlled which have issued from his department in steady methods of experimental research to problems of sequence, Lewis has assembled and discussed the clinical medicine. This has enabled him to achieve results, in their appropriate connexions, in a succes a detailed analysis of abnormalities of function sion of comprehensive monographs. He has been the produced by disease, injury or hereditary defect ; inspiring leader of a group of younger workers in and so far his attention has been centred upon the clinical research as an experimental science, has circulation of the blood and its disorders. Being founded a Society for such studies and has devoted attracted through the work of the late Sir James to their use a journal which he had started with a Mackenzie to the study of abnormal rhythms of the more limited scope. human heart-beat, Lewis recognized, about 1908, The work of Thomas Lewis, which we honour to the great opportunity for a closer investigation of day with the highest recognition in the gift of the them offered by the then recent introduction of the Royal Society, is -renewing and carrying forward, string galvanometer by Einthoven. With its aid with a special directness, the great tradition which Lewis had soon made a number ·of clinical and William Harvey created, before this Society was laboratory studies, such as those in which he finally founded. identified auricular fibrillation as the cause of a ROYAL MEDALS particular kind of complex irregularity. He was A Royal Medal has been awarded to Prof. Edward thus led to undertake, and to extend, with a succes Arthur Milne. sion of collaborators from ·many countries, the Milne is distinguished for his work on planetary remarkable series of investigations, carried through and stellar atmospheres, on the internal constitution in logical sequence between 1910 and 1923, in which of the stars, and on the theory of relativity. An he passed from the laboratory to the clinic and back early paper on various properties of the earth's again as the occasion demanded. atmosphere, up to high levels, led later to a valuable It is fitting that special mention should here be improvement of the theory of the escape of planetary made of the series of experimental studies published atmospheres by the passage of the fa8ter moving in the Philosophical Transactions during 1914-1916, molecules out of the range of the gravitational field. and presented in brilliant summary by Lewis in his Thence he passed on to a long series of investigations Croonian Lecture to the Society in 191 7. In these on radiative equilibrium and the theory of the were traced, with an astonishing precision of measure atmospheres of the sun and stars. ment and timing, the point of origin and exact Next, partly in collaboration with R. H. Fowler, course of the rhythmical waves of excitation and he improved and extended Saha's theory of the contraction in the normally beating heart of the absorption lines in stellar spectra, obtaining a relation dog, and, finally, for comparison, in the hearts of between the maximum strength of a line and the other classes of vertebrate animals. Considered by mean pressure and temperature in the atmosphere. itself, this work ranks as one of the outstanding Afterwards Milne generalized this theory, providing a!)hievements of experimental physiology in our times, a rational foundation for the astronomers' empirical and it has given to physiology a large part of its method of determining stellar parallaxes from the present detailed knowledge of the nature of the spectra. heart-beat. For Lewis, however, its greater import Later he considered the equilibrium of the calcium ance lay in giving to clinical medicine the background chromosphere of the sun, and also discovered a for an accurate picture of disturbances of the normal method by which outward-moving atoms capable mechanism, therewith a new security of diagnosis of absorbing radiation in the region of the chief and prognosis in dealing with disordered actions of absorption lines can be accelerated and pass beyond the heart, and ultimately a rational basis for their the range of the sun's attraction, attaining a limiting treatment. A new phase of cardiological thought speed of about a thousand miles a second. This and practice spread rapidly from Lewis's clinic theory also has an application to 'new' stars. round the world. Milne then considered the deeper layers of the Meanwhile he had begun in 1917, and was to atmosphere (for example, in the case of the sun, the maintain with a series of collaborators for more than photosphere), which in 1929 he took as the subject another decade, a separate series of. investigations, of his valuable Bakerian Lecture. He has also given dealing by direct experiment with the blood vessels a theory of the structure of sunspots and of the of the human skirt. Thus were elucidated the means circulation associated with them. by which the resistance of these vessels to the flow of In 1929 he began a new series of researches on the blood is maintained and varied, including their radiative equilibrium of gas spheres, designed to complex reactions to chemical substances akin to improve the theory of the internal constitution of the histamine, which he proved to be released from the stars. His work in this field was specially important cells of the epidermis by injuries or irritant stimuli. in focusing attention on the properties of degenerate These methods of investigation were later developed matter. and extended to vascular disorders of the limbs, and In 1932 Milne began an altogether different series • From rere arks made by Sir Henry Dale In presenting the medals of investigations, bearing on the largest topics of as for 1941. tronomy and cosmogony, and providing an alternative © 1941 Nature Publishing Group 700 NATURE DECEMBER 6, 1941, VoL. 148 to the general theory of relativity developed by additions to knowledge of the intermediary changes Einstein and his foJlowers. He has made a valuable produced by these activities, and also of the chemical analysis of the concept of time, and his kinematical structure of natural components of the tissues. theory of gravitation has some promise of a possible One side of Dakin's work has dealt with enzymes extension to include also electromagnetism. of the animal organs. He was the first to show that Milne's later work has been the subject of much such an enzyme will attack at different rates the controversy : but the originality and boldness of his two optical isomers in a racemic mixture. With attack seem certain to promote our understanding of Kosse! he discovered the enzyme arginase, with its these great problems. important role in the production of urea from arginine. Later he discovered the enzyme glyoxalase, the wide A Royal Medal has been awarded to Prof. Ernest distribution of which in the tissues must indicate Laurence Kennaway. some important though still undefined function in Kennaway is the director of the Chester Beatty carbohydrate metabolism. Research Institute of the Royal Cancer Hospital, In connexion with the intermediary metabolism and has been engaged for the past twenty years in of fatty acids, Dakin produced the first convincing investigations on the of cancers by the evidence of oxidation at the [?.-carbon atom as the continued effects of chemwal agents. The long first stage of their utilization by the body, and showed known liability to skin cancer of men whose work that this type of oxidation can even be reproduced involves regular contact with soot, coal tar, or in vitro by the action of hydrogen peroxide. pitch, and the more recently demonstrated produc Dakin's work on the chemistry of the proteins has tion of such cancers in animals by painting the skin included a method of partial racemization, bringing with tar, had raised the question whether a specific subtle differences of molecular pattern into view, chemical agent was concerned, or only a sufficiently which could be related to specific antigenic differences. persistent irritation. The fractionation of coal tar, He also introduced a method of separation which in search of a substance revealing its action only after enabled new hydroxyamino acids to be recognized, tedious months of experiment, was an undertaking and raised much nearer to unity the proportion of a to daunt any but a devoted investigator. Kennaway protein molecule accounted for as known amino embarked on this quest, and after years of labour. acids. At a wide interval of years, Dakin has made the .fluorescence studies of his co-workers Mayneord two notable contributions to the chemistry of hor and Rieger made it possible to isolate a pure substance mones. In 1905, he was resonsible for the first from tar with intense carcinogenic activity, and published artificial synthesis of a hormone, adrenaline. ultimately to identify it as benzpyrene. This In 1936 he described the isolation from liver of a identification and its confirmation by synthesis were substance which is, at least, a principal factor in the due to J. W. Cook. important effect of liver extracts on pernicious Meanwhile, the observation that active fractions aiUBmia.

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