SCHOOL OF CHEMISTRY Annual Report 2012

www.chemistry.unimelb.edu.au 1 SCHOOL OF CHEMISTRY Annual Report 2012

SPONSORS Agilent Technologies Australian Nuclear Science and Technology Organisation Australian Research Council Australian Synchrotron BHP Billiton Chemistry Education Association Inc Dairy Innovation Australia Ltd Dulux Australia Huntsman Corporation Australia Pty Ltd Melbourne Water National Health and Medical Research Council Peter MacCallum Cancer Institute Stawell Gold Mines

CONTACT THE SCHOOL Chemistry Building The University of Melbourne Victoria 3010 Australia +61 3 8344 6567 www.chemistry.unimelb.edu.au

Compiled by Jenny Long [email protected]

FRONT COVER IMAGE Materials prepared by Dehong Chen and Lu Cao within the School of Chemistry’s Caruso research group. These mesoporous titania beads with spiky particles decorating the surface have been tested in dye-sensitised solar cell applications, in collaboration with Monash University, achieving over 10 % efficiency.

2 School of Chemistry Annual Report 2012 CONTENT

Introduction from the Head of School 4

Our People 5

News 6

Societies 14

Chemistry Building redevelopment 15

Prizes and Awards 17

Chemistry Outreach Program 18

Alumni Function 2012 19

Subjects 20

Key teaching and learning statistics 21

Research Higher Degree student completions 22

Research Funding 2012 23

ARC Centre of Excellence for Free Radical Chemistry and Biotechnology 25

Conferences 2012 26

Inorganic and Analytical Chemistry Seminar Program 31

Organic Chemistry Seminar Program 33

Physical Chemistry Seminar Program 35

Publications 2012 36

www.chemistry.unimelb.edu.au 3 INTRODUCTION FROM THE HEAD OF SCHOOL

Once again we present the Annual Our outreach activities on campus and Report from the School of Chemistry at schools throughout Victoria engage and celebrate some of our many students at all levels. The Melbourne accomplishments in 2012. The School University Chemical Society hosted is one the oldest and largest chemistry the Lady Masson Lecture by our new departments in Australia: lectures Provost, Professor Margaret Sheil, in chemistry have been given at the which was a highlight of our public University of Melbourne since 1856. lecture program. The reputation of the School continues Following a re-structure of Professional to grow as evidenced by the outcomes Staff in the Faculty of Science during of the 2012 QS World University 2012, we farewelled Marg Ross (School Ranking for Chemistry. Despite the Manager) and Fran Dynan (Finance vagaries of the ranking systems, we Manager) and thank them for their were delighted that the University of service to the School of Chemistry. Melbourne came in highest in Australia and at 20 in the world to I invite you to read about our study chemistry. performance in teaching, research and engagement, which are briefly The School continues to perform summarized in the following pages, strongly in research with successes and reinforce that the School of in the Australian Research Council Chemistry is a great place to study (ARC) grant schemes, including a and do research. Future Fellowship to Dr Georgina Such and Discovery Early Career Awards to Dr James Hutchison and Dr Chris Ritchie. The School also hosts the ARC Centre of Excellence for ‘Free Radical Chemistry and Biotechnology’ and is Professor Frances Separovic FAA a participant in two other centres. The excellence of our researchers has been recognized in several ways, including the awarding of the Royal Medal to Laureate Professor Andrew Holmes in recognition of his outstanding career achievements. I was also honoured to be elected as the first female chemist to the Australian Academy of Science. Meanwhile, major refurbishments of the Chemistry Building continue. The new physical chemistry research laboratories on Level 1 East were occupied in March 2012. The final research laboratories in the East Wing of the Chemistry Building, Level 2 East, are planned for completion in 2013. This will see the School with modern research laboratories located primarily in the East Wing and at the Bio21 Institute, together with the new teaching laboratories in the West Wing of the Chemistry Building.

4 School of Chemistry Annual Report 2012 OUR PEOPLE

ACADEMIC Future Generation Fellows Amber Hancock Peter McTigue Rachel Caruso Xiaotao Hao Richard Morrison Head of School John Gehman Clare Henderson Geoffrey Scollary Frances Separovic James Hickey Peter Tregloan ARC Australian Professors Postdoctoral Fellow Timothy Hudson Charles Young Muthupandian Ashokkumar George Khairallah David John Jones Senior Fellows Evan Bieske Yvonne Kavanagh Robert Craig ARC Australian Ken Ghiggino Shea Fern Lim Valda May McRae Postdoctoral Fellows Franz Grieser Anthony Morfa Linda Feketeova Fellows Spas Dimitrov Kolev Tich-Lam Nguyen Elizabeth Krenske Richard David Harcourt Robert Lamb Adabelle Ong Akhter Hossain Richard Alfred O’Hair Centenary Fellow Brett Paterson John Lambert Mark Antony Rizzacasa William ‘Alex’ Donald Christopher Ritchie Alessandro Martucci Carl Herbert Schiesser Hadi Lioe Tatiana Pinedo Rivera Suzanne Reichman Marc Antoine Sani Denis Scanlon Christine Schieber Gerard Wilson Colin Skene Andrew Tilley PROFESSIONAL Willem Van den Huevel West Precinct Manager Phillip Van der Peet Eugene Fredericks Krista Vikse West Precinct Huabin Wang Facilities Manager Xingzhan Wei Paul Beardsley Keith White Christian Wichmann Renee Beale Vicki Burley Tutors Alex Wu Associate Professors and Fran Dynan /or Readers Penelope Commons Zhiguang Xiao Gregory Ellis Brendan Francis Abrahams Sonia Horvat Yanlin Zhang Robert Gable Rachel Caruso Meifang Zhou Chemistry Outreach Sue Hickey Michelle Louise Gee Fellow HONORARY Ross Lineham Craig Hutton Michael Moylan APPOINTMENTS Jenny Long Trevor Alexander Smith Emeritus Professors Brendan Mangan Jonathan Michael White Research Associates Donald William Cameron Bryan McGowan Uta Wille Sneha Abraham Abigail Albright Francis Patrick Larkins Alf Meilak Senior Lecturers Elizabeth Mills Klaus Boldt Professorial Fellows Stephen Peter Best Peter Mills Gojko Buncic Robert Cattrall Colette Boskovic Des Odgers Nahid Chalyavi Roger Francis Martin Paul Donnelly Charlie Penman Janage Chandrapala Ezio Rizzardo Spencer John Williams Lachlan Pollock Maryine Chee Kimling Richard Robson Marg Ross Lecturers Dehong Chen Peter Robert Taylor (Business Manager) Angus Anthony Gray-Weale James Cochrane John Desmond Wade Craig Sanders Alessandro Soncini Christopher Dean Donner Robert Oliver Watts Jennifer Scott Augustine Doronila John Webb ARC Laureate Fellows and Alexandra Strich Viktoras Dryza Anthony Gordon Wedd Professors Doug Taylor Alex Duan Paul Mulvaney Joe Tyler Linda Feketova Principal Fellows Sioe See Volaric Laureate Professor Maria Ines Gameiro SA Almeida Christopher Burns Andrew Bruce Holmes Catrin Goeschen William David McFadyen Christian Gunawan Ian McKelvie

www.chemistry.unimelb.edu.au 5 NEWS

From time to time, School of Chemistry staff and students make the news! Below are excerpts from, and links to news stories and articles from 2012 about the School of Chemistry, from print and electronic media.

How viruses play PNAS article for Linda Chan awarded biological ‘piggy-back’ Donnelly group NH Schuster Research from Paul Donnelly’s Group Scholarship An international team of scientists in collaboration with Dr Peter Crouch led by Assoc Prof Spencer Williams C Linda Chan, PhD student with Prof from the Dept. of Pathology was from the School of Chemistry John Wade and Prof Frances Separovic, published in PNAS. A copper complex and Bio21 Institute and Professor was awarded the 2012 Norma Hilda under investigation as an imaging Gideon Davies from the University Schuster (nee Swift) Scholarship. agent for the diagnosis of tumours of York determined the structure The scholarship is awarded for is selectively trapped in cells with of the enzyme endomannosidase, academic merit to a student enrolled an impaired mitochondrial electron significantly advancing our in the Faculty of Science undertaking transport. Radioactive versions of understanding of how a group graduate research in the field of the copper complex are used as of devastating human viruses biochemistry. radiopharmaceuticals for diagnosis including HIV and hepatitis C hijack of cancers using positron emission human enzymes to reproduce Victoria-India tomography (PET). Hypoxic tumours, and cause disease. In work ischemia, and Parkinson’s disease Doctoral Scholarship reported in the Proceedings of the all involve impaired mitochondrial to Chemistry PhD National Academy of Sciences function so there is potential this student USA (PNAS) they studied bacterial copper complex could be used as a PET endomannosidase as a model Sayali Shah was the successful Uni imaging agent in other mitochondrial for the same human enzyme and Melb PhD applicant for the Victoria diseases. successfully determined the 3D India Doctoral Scholarship as Sayali structure using state-of-the-art completed a Masters from University synchrotron technology. Knowing Brandon MacDonald of Pune and her supervisor here will be the enzyme structure revealed how awarded student Spencer Williams. viruses play biological ‘piggy-back’, prize at ICONN 2012 borrowing our cellular machinery PhD student, Brandon MacDonald, University lab opened to replicate and cause disease. The from the Mulvaney lab was awarded to VCE Chemistry findings were widely reported on a prize at the 2012 International ABC News and Radio, in the Herald students Conference on Nanoscience and Sun and in various online sources The School of Chemistry hosted 1,100 Nanotechnology (ICONN 2012) in Perth nationally and internationally VCE Chemistry students from regional in early February. Brandon MacDonald areas for ‘A Scientific Entrée’, a new won a Best Poster Prizes for his work: University program which focuses on “A Scaleable, Non-Injection Synthesis food and agriculture. of CdTe Nanocrystals for use in Solution-Processed Solar Cells”.

Chemical Communications front cover for Donnelly/Wedd group A paper by Gojko Buncic from Paul Donnelly’s and Anthony Wedd’s Image created by Spencer Williams: research groups featured on the front “X-ray data showing a ternary complex of cover of Chemical Communications. the inhibitor Glc-IFG and product mannobiose bound to endomannosidase”. The paper describes the isolation and characterization of a Cu(II) complex of a non-innocent quadridentate ligand, where the ligand is a pi-radical anion.

6 School of Chemistry Annual Report 2012 Frogs thwart Chemistry Alumni International funding hospital superbugs awarded prestigious for Printed Solar Cells Research on antimicrobial peptides VESKI fellowships VICOSC researchers, Wallace Wong at the School of Chemistry featured Two of our alumni, Dr Seth Masters and David Jones, have been awarded in the Sydney Morning Herald. The (Hons with Prof. Tony Wedd) and funding as part of the Australian Solar article “Hospital hero? This frog has the Assoc. Prof. Tiffany Walsh (Hons with Institute (ASI) Australia-Germany makings of a lifesaver” featured research Prof. Frank Larkins), were awarded Collaborative Solar R&D fund for leader Professor Frances Separovic. VESKI Fellowships. Seth is working their project “Enhancing efficiencies at the Walter & Eliza Hall Institute and in printed solar cells by controlling Zalihe Hakki attends Tiffany is at Deakin University. morphology development”. They 2012 HOPE conference received ASI contribution: $500,000; Total project value: $1,213,235 in Tsukuba, Japan Congratulations Partners: Light Technology Institute and Zalihe Hakki, a PhD student in the to newly elected Laboratory for Electron Microscopy at Williams research group, attended Fellow of the Karlsruhe Institute of Technology. the 4th HOPE in Tsukuba, Japan. Australian This prestigious meeting, hosted by Academy of Science 2011 Prizes the Japan Society for the Promotion of Science, aims to foster talented - Professor Frances The School of Chemistry congratulates young researchers in the Asia-Pacific Separovic the following students who were region in the Science & Technology awarded prizes based on their 2011 disciplines. The meeting was attended results. by ~ 100 students from 17 countries • Dwight Prize - Yi Lin Kang who were involved in presentations by • Exhibition Prize - Rama Lokon 9 Nobel Laureates and other eminent researchers working on the leading • Charles Anthony Taylor Prize - edge of science from around the world. Stephanie Kusumo The week culminated in presentations • Huntsman Australia Prize - Samuel by groups of students. The presentation Tucker by Zalihe’s group on the IgNobel Prize Professor Frances Separovic was • Dulux Prize - Edward Nagul was judged the winner. admitted as a new Fellow to the • J. S. Anderson Prize - Kenichi Australian Academy of Science AAS). Nakanishi Frances is recognised for her work in • James Cuming Major Prize - “Using solid-state nuclear magnetic Merinda Healey resonance to advance understanding • James Cuming Minor Prize - of how peptides get into membranes, Matthew Lovell with applications for antibiotics and Alzheimer’s disease”. The prestigious • Fredrick Walker Prize - Kenichi award is one of the country’s highest Nakanishi honours recognising a career that • Kernot and Stanley Harvey Prizes - significantly contributes to the world’s Jessica Holmes scientific knowledge. Representing Photo: Zalihe meeting Nobel Laureates Daniel • Dixon Research Scholarship - Schechtman (Chemistry 2011) and Makoto Australia’s leading research scientists, Matthew Burton Kobayashi (Physics 2008). the AAS annually honours a small • Ronald Riseborough Prize - Sarah number of Australian scientists for Jaber Miegunyah Lecture their outstanding contributions to • Monica Reum Prize - Phillip van der success science, by election to the Academy. The new Fellows hail from institutions Peet Over 200 people attended the around Australia and have made Miegunyah Lecture by Prof J Ruzicka internationally significant Australian Leadership entitled ‘Analytical chemistry and its achievements in a broad range of Award to Rachel invisible presence in our everyday life’ scientific disciplines. The new Fellows Caruso held in the Masson Theatre in March. were admitted to the Australian Academy of Science on 2 May in Assoc Prof Rachel Caruso was selected Canberra. as a recipient of a 2012 Australian Leadership Award. The Award recognizes Rachel’s leadership in her field and was presented on 14 May at the ADC Future Summit.

www.chemistry.unimelb.edu.au 7 Dean’s Award ARC Linkage Grant to International for Excellence in Spas Kolev Chemistry Conference: Research to Paul Prof Spas Kolev was awarded an 1-6 July 2012 Donnelly ARC Linkage grant in the recent round for the project, “The pollution Professor Mark Rizzacasa from The School congratulates Dr Paul the School was a key organiser of Donnelly who was awarded the 2012 potential of mercury in legacy biosolids and possibilities for its the 19th International Conference Dean’s Award in recognition of his on Organic Synthesis (ICOS). Over excellence in research. minimisation by phytoremediation and phytostabilisation approaches”, 550 leading organic chemists together with the Melbourne Water and researchers from 33 different Healy Travel Award Corporation, Southern Illinois University countries were in Melbourne for to Stefanie Alexander Carbondale, University of the Balearic ICOS 2012. Speakers included Nobel Laureate Professor Ei-ichi Negishi, Stefanie-Ann Alexander was selected Islands, and Victorian Environmental Purdue University; Professor Amos B as the 2012 recipient of the TW Healy Protection Authority. Smith III, University of Pennsylvania, Travel Award. and Editor-in-Chief of the American Student Prize for Y Cho Chemical Society journal, Organic Grimwade Prize to PhD student, Youngsoo Cho, from Letters; Professor Margaret Brimble, Rob Lamb the Kolev lab received an award for L’Oreal-UNESCO Women in Science ‘outstanding poster presentation’ at Laureate 2007; and Professor Minoru Congratulations to Professor Rob Lamb the 7th Aseanian Membrane Society Isobe, Tsing Hua University, Taiwan, who was awarded the 2011 Grimwade Conference (Busan, South Korea, July recipient of the Purple Ribbon Medal Prize in Industrial Chemistry. 4-6). Congratulations Youngsoo. of the Emperor of Japan. ICOS 2012 was organised by the Royal Inspiring Australia Materials of Life Australian Chemical Institute (RACI) grant Symposium, and the International Union of Pure and Applied Chemistry (IUPAC). Dr Renee Beale was awarded an 29 June 2012 ‘Inspiring Australia’ grant from the Australian Government to run a program The School co-sponsored the called Insight Radical. Rene’s project Symposium held at the Melbourne partners, Winsor & Newton, are also Brain Centre Auditorium, providing generous support. Insight Neurosciences Bldg, The University of Radical aims to create dialogue in the Melbourne. The plenary speaker was broader community about free radicals Professor Liz Blackburn, 2009 Nobel and their impact, both positive and Prize in Physiology or Medicine with negative, on health, materials and the talks from: Rachel Caruso, Matt Dixon environment. This will be achieved by: and Justine Mintern (University of Melbourne) and John Sedat (University Image: Professors Andrew Holmes, Mark • Hosting artists in the Free Radical of California San Francisco). Rizzacasa (UoM), Amos Smith and Jenny Centre laboratories and holding Holmes at the ICOS19 mixer. public exhibitions in Melbourne, Australian Workshop Sydney and London of artwork, for Chemical Biology, Young Investigator • Presenting science art workshops 29 June 2012 Award for Paul for members of the public in Donnelly regional areas, The School of Chemistry and Bio21 were proud to host the Australian Dr Paul Donnelly received a Young • Presenting a science art program for Workshop for Chemical Biology at Investigator Award at the recent Gordon the Broken Hill community, and the Bio21 Institute Lecture Theatre Research Conferences on Metals In • Working with Indigenous on 29 June. The workshop featured Medicine in Andover, NH, USA. Paul communities in the Northern keynote presentations from speakers received the honour in recognition of Territory. around Australia, including Profs David his contributions to research in metals Fairlie and Jenny Martin (University in medicine and presented a talk titled of Queensland), Prof Dale Godfrey “Metal Complexes for the Diagnosis of (University of Melbourne) and Alzheimer’s disease and Cancer”. Dr Chris Burns (WEHI), as well as the international plenary speaker, Prof Peter Hutton Group Poster Wipf (University of Pittsburg). The day Prize concluded by joining with the Material of Life Symposium to hear a plenary Aaron Brown (PhD student in the lecture from Prof Liz Blackburn (2009 Hutton group) won an RACI Feutrill Nobel Prize in Physiology or Medicine). poster prize at the 19th International The Workshop was enabled through Conference on Organic Synthesis/24th Renee Beale presenting at an Insight Radical funding from the Office of the Deputy RACI Organic Conference held in science/art workshop in Cairns. Vice Chancellor (Research). Melbourne.

8 School of Chemistry Annual Report 2012 Congratulations to Prof Andrew Holmes on Linda Chan wins RACI award of 2012 Royal Medal Student Travel Award Congratulations to Linda Chan received Professor Andrew Holmes was awarded a 2012 Royal an RACI Postgraduate Student Medal from the Royal Society, London. Three Royal award for travel to the 2012 Relaxin Medals, also known as the Queen’s Medals, are awarded conference in Florence. annually for the most important contributions in the physical, biological and applied or interdisciplinary sciences. Former recipients include Charles Darwin, ARC Future Francis Crick and Suzanne Cory. Andrew is a University of Fellowships awarded Melbourne Laureate Professor of Chemistry at the Bio21 to Chemistry Institute, a CSIRO Fellow and a Distinguished Research The School of Chemistry congratulates Fellow at Imperial College London. He is recognised for his Dr Georgina Such and Dr Elizabeth contributions at the interface of the materials and Krenske who recently were awarded biological sciences that will lead to outcomes that will benefit society. He played ARC Future Fellowships. Georgina is a pioneering role in the field of applied organic electronic materials. In the late an alumni of the School and we look 1980’s he established a collaboration with University of Cambridge physicists forward to her joining us again in 2013. that in 1990 led to the discovery of light emitting polymers and led the chemistry Her project is entitled ‘Advanced bio- team in that collaboration for 14 years. These polymers have applications in solid inspired polymer assembly: tools for state (LED) lighting, flat panel displays, transistors and solar cells. In Australia diagnostics, imaging and therapies’. Professor Holmes leads the Victorian Organic Solar Cells Consortium involving This project will involve the synthesis the University of Melbourne, CSIRO, Monash University and industry partners. and application of ‘smart’ polymer films and particles, which mimic biological behaviour. Smart polymeric materials have the potential to make a significant impact in areas such as healthcare but to do this effectively the materials will need to respond intelligently to biological signals. Elizabeth’s project, ‘Theoretical modelling and design of safe covalent anti-cancer drugs’, will be carried out at the University of Queensland.

Chemistry in Top 20 QS World Ranking The 2012 QS World University Ranking for Chemistry lists the best universities in the world to study chemistry. University Photo Credit: Dr Noel Clark. of Melbourne comes in highest in VICOSC new micro-Coater printer with a 30 cm web: Printing the active layer of an organic solar cell. Australia and at 20 in the world. Staff Engagement Recollections of a Selby Research Award Excellence Award to Scientist, Volume 1 to Angus Gray-Weale Mick Moylan One of our alumni published a book Congratulations to Dr Angus Gray- Mick Moylan was awarded a Staff about his youth in Melbourne and Weale who received the Selby Engagement Excellence Award for his studying chemistry here. Prof Norman Research Award this year. The purpose outreach activities with Chemistry in Greenwood FRS has been writing of the award is to assist an outstanding Schools on 28 Sep. Well done Mick! his memoirs and the first volume, academic to establish his or her dealing with his boyhood and youth in research career in Chemistry or related Australia (1925-48) is out. There are full disciplines, within five years of their descriptions of school and university first appointment at The University of life in Melbourne at that time and of the Melbourne. six members of academic staff of the School, who carried all the teaching load. Also of the CSIR(O) laboratory in which he worked as a technician in the ‘new’ Chemistry Building during the war.

www.chemistry.unimelb.edu.au 9 Interview with Chemistry in Top 20 QS Feutrill Awards Professor Andrew World Ranking Congratulations to the following Holmes on ABC Radio The 2012 QS World University Ranking students who received Feutrill awards Prof Andrew Holmes was on the for Chemistry lists the best universities to participate in an international Midday Interview on Wed 8 Aug with in the world to study chemistry. conference related to organic Margaret Throsby on ABC Classic FM. University of Melbourne came in highest chemistry: Jenny Chambers (Rizzacasa); Andrew is University Laureate Professor in Australia and at 20 in the world. Linda Chan (Separovic); Luke Gamon of Chemistry and Bio21 Institute at the (Wille); Emma Read (Wille); and Mark University of Melbourne, CSIRO Fellow Publication in PNAS Richardson (Williams). and Distinguished Research Fellow in for Anthony Wedd the Department of Chemistry (Imperial Open Day at College). He is a pioneer of research in Cheap catalysts for the photo- organic electronics. oxidation of water are highly Chemistry desirable for potential application Sunday 19th August was the Lady Masson in artificial photosynthetic systems. University of Melbourne Open Day. This work showed that the simplest Memorial Lecture Staff from the School of Chemistry polyoxometalate anions are robust answered queries about course delivered by Provost catalysts in the presence of ionic liquids advice and careers throughout the The 2012 Lady Masson Lecture was (liquid salts), or at the interface between day. The guided tours of the School given by Professor Margaret Sheil, aqueous and ionic liquid phases. It of Chemistry’s facilities were very Provost, University of Melbourne. The appears that the photo-active anion popular. Over 900 people were lecture, entitled “What we can learn provides one activated water molecule taken on the tour that included from Thomson, Heisenberg and Florey in (as an oxide ligand) and the ionic liquid a demonstration of interactive framing research and innovation policy,” provides another (by disrupting the technology used in tutorials in the was held on Wed 8 Aug in the historic hydrogen bonding network of bulk Learning Lab, visits to the Learning Masson Theatre to a diverse audience. water). This allows efficient formation Centre and Labyrinth and the historic of dioxygen from the oxidation of two Masson Theatre, and research MUCS Life Membership water molecules. displays in the Level 1 undergraduate teaching laboratory. to Dr Valda McRae PhD student Julia Prior to the Lady Masson Memorial Baldauf wins lecture on Wed 8 August, Dr Valda Victorian Young McRae was presented with a Life Nanotechnology Membership certificate of the Melbourne University Chemical Society Ambassador Award (MUCS) by the current president, Prof. PhD student Julia Baldauf of the Evan Bieske, in recognition of her Mulvaney Group won the Victorian valuable service to MUCS. We all greatly Young Nanotechnology Ambassador appreciate Valda’s great contribution to Award given by the Australian Chemistry at Melbourne. Nanotechnology Network for her enthusiastic involvement in promoting Publication in science and science education. Image Courtesy Alex Strich. Post Doc Chemical Science for Julia has been actively engaged in Klaus Boldt and Fabio Lisi, PhD student to Paul Donnelly’s group outreach activities including visits to the Mulvaney Lab with Open Day visitors metropolitan and regional schools to in Lab. Collaborative work from the groups of inspire students about nanotechnology Paul Donnelly, Tony Wedd and Anthony and more broadly science education. Journal Cover for White (Pathology) has been published Caruso Group in Chemical Science, a new journal for Student prize at findings of exceptional significance IOSEC12 awarded to Materials prepared by Dehong Chen and published by the Royal Society of Lu Cao of the Caruso group have been Chemistry. The research highlights that Jesse Roth-Barton displayed on the cover of Chemistry - A the chemical complexity of living cells Jesse Roth-Barton, a PhD student European Journal. These mesoporous can have a diverse effect on the action with the White & Ghiggino labs, was TiO2 beads with spiky particles of molecular probes designed to detect awarded a best poster prize at the decorating the surface have been tested specific intracellular pools of copper. International Organic Excitonic Solar in dye-sensitized solar cell applications, Copper is an essential bio-metal Cell Conference (IOESC: 12) that in collaboration with Monash University, involved in critical cell functions and was held at Coolum QLD, Sep 2012. achieving over 10% efficiency. the progression of neurodegenerative Jesse’s presentation was entitled diseases but the mechanisms “Diketoprryolopyrroles for solar cells: controlling its sub-cellular localization synthesis and performance”. during health and disease remain poorly understood.

10 School of Chemistry Annual Report 2012 Frances Separovic Insight Radical: Angewandte Chemie elected ISMAR Fellow where science meets publication for Professor Frances Separovic was elected art blog Mulvaney, Donnelly Fellow of the International Society and Williams groups of Magnetic Resonance (ISMAR) to A multidisciplinary collaboration honour her ‘as a leader in NMR studies involving the Nanoscience (Mulvaney), of membrane structure and biophysics, Donnelly and Williams laboratories, as mostly using solid-state NMR’. well as colleagues in the Biochemistry and Pathology Department, has been Nature publication published in Angew. Chem. Int. Ed. for O’Hair & (2012, 51:10523). The work reports a Khairallah novel and widely applicable conjugation strategy that allows the controlled An Australian research team has attachment of highly-fluorescent discovered how specialised immune quantum dots to a variety of biological Photo Courtesy: Renee Beale. Artist cells recognise products of vitamin B targets, ranging from proteins to synthesis that are unique to bacteria Peter Sharp with Centre Scientist Yvonne Kavanagh. antibodies, peptides and DNA. The and yeast, triggering the body to fight utility and success of the conjugation infection. The work has recently been Follow the journey of 6 artists and platform was demonstrated through published in Nature and the co-authors 9 scientists through a project called labelling of the iron-carrier protein include Professor Richard O’Hair and Insight Radical: where science transferrin, enabling the tracking of its Dr George Khairallah from the School meets art. In Insight Radical, artists cellular uptake and distribution within of Chemistry. See the following news and scientists come together at the the cell. items: intersection of art and science to consider the impact of free radicals • Researchers discover how the on health, the environment and on body uses vitamin B to recognise the longevity of artwork. The Insight bacterial infection Radical blog was established in • How the Body Uses Vitamin B to August 2012 to document current Recognize Bacterial Infection developments in the program until • How the Body Uses Vitamin B to its completion in December 2013. Recognize Bacterial Infection The regularly updated blog includes stories, images and video arising from artist residencies in the Free Angewandte Chemie Chemistry student Cover for Williams in Chemistry World Radical Centre laboratories and artists’ studio visits, as well as Group finals in London images of artwork produced as a A multidisciplinary study utilizing consequence of the residencies, Congratulations to James Banal, a synthetic chemistry, protein reactions to the project from BSc (Hons) student this year in the crystallography, and computational scientists and artists, and details Wong and Ghiggino groups, who studies involving Dr Zoran Dinev from of upcoming public art/science attended the award ceremony in the Williams group has been featured workshops and exhibitions relating London for the Chemistry World on the cover of Angewandte Chemie. to the program. Visit the Insight Science Communication Competition The study reports how an mannosidase Radical blog at: http://www. 2012. James’ article ‘Diagnostics on enzyme restricts the conformational insightradical.org Insight Radical paper’ was one of the finalists for this space of its substrate, a mannose is proudly supported by the ARC worldwide competition. sugar, upon binding. Centre of Excellence for Free Radical Chemistry & Biotechnology (School of Chemistry, University of ECR grant to Chris Melbourne), Winsor and Newton, Ritchie Artist Profile magazine, and the Dr Chris Ritchie was awarded an Commonwealth Government Early Career Research grant for his through an Inspiring Australia grant. project, “Design and Development of Organic-Polyoxometalate Based Photo- Switchable Devices”.

www.chemistry.unimelb.edu.au 11 Round 2 Healy Awards Chemistry Graduates Radicals in the Announced receive Tall Poppy gallery and Nature’s Alessandra Bestelli and Robert Elliott Awards art vandals who were joint winners of the round 2 Two of our graduates have been Professor Carl Schiesser and art Healy Travel Award, 2012. Alessandra awarded Victorian 2012 Young Tall conservator, Caroline Kyi, discussed will travel to London in November Poppy Science Awards: how understanding the effect of free 2012 to attend the International radicals on pigment helps art galleries 1. Dr Colin Scholes (Chemical & Conference on Nanotechnology in and museums preserve important Biomolecular Engineering), who Medicine “NanoMED”, and Robert will works of art. Podcast presented by is developing efficient filtering attend the International Symposium Dr Shane Huntington, “Radicals in membranes to separate carbon from on Macrocyclic and Sypramolecular the gallery: scientists contend with industry gases such as coal-fired Chemistry 8 in Crystal City, Virginia in Nature’s art vandals” http://upclose. power stations. July 2013. unimelb.edu.au/episode/224-radicals- 2. Dr Georgina Such (Chemical & gallery-scientists-contend-nature-s- PhD student Biomolecular Engineering), who is art-vandals “Some artists believe that biophysics award investigating better ways to deliver the degradation process is part of the chemotherapy drugs by designing a artwork and, therefore, the fact that Matthew Burton received an Australian smart capsule that is specially designed the painting decays or changes colour Society for Biophysics award for to protect the body from the drug is actually not detrimental in the eyes his poster ‘Probing slow interaction until it reaches the specific cancer of the artist. You know the question dynamics of a model lytic peptide with site. Georgina will take up a Future depends upon the work of art that the giant unilamellar vesicles’ presented at fellowship in the School in 2013. artist intended.” - Prof Carl Schiesser the Fluoro 2012 workshop. Matthew is a PhD student with the Gee Soft US-Australia Institute Condensed Matter Group. Go8 Australia- Germany Research for Advanced McKenzie Fellowships Cooperation award Photovoltaics The School is delighted to be hosting Assoc Prof Uta Wille’s application, The Australian Solar Institute two McKenzie Fellows in 2103: Dr ‘Radical intermediates in photo- announced major research grants Marco Lista from the Mulvaney lab catalysis with Visible Light’, was to support solar energy research. and Dr Willem van der Heuvel from successful in obtaining funding from Congratulations to the organic the Soncini group, who were both the Group of Eight Australia-Germany photovoltaic researchers in the School successful this year. Joint Research Co-operation Scheme. of Chemistry (Andrew Holmes, David Jones, Ken Ghiggino) who will National Grant Quantum step form a node of the new $33 million towards on-the- US-Australia Institute for Advanced Awards Photovoltaics. This Institute’s objective spot Hendra virus is to develop the next generation of Congratulations to the following detection members of the School who were photovoltaic technology and involves successful in the latest round of ARC CSIRO scientists, in collaboration with participation from key research groups and NHMRC grant awards: Alex Donald, Chemistry researchers at the Bio21 in USA and Australia Universities, James Hutchison and Chris Ritchie are Institute at the University of Melbourne, research organisations together with DECRA recipients; Paul Mulvaney, Carl have developed a new method which industrial supporters. Schiesser, Tony Wedd and Spencer could pave the way for a portable Williams received Discovery grants; Hendra virus biosensor. http://www. Nanotech Network Frances Separovic is a co-CI on an csiro.au/Portals/Media/HENDRA-Virus- Young Scientist NHMRC grant; and Bieske, Smith & Detection.aspx Ambassador Ghiggino are co-CIs on a LIEF grant with Adelaide and Wille & Wedd are co-CIs Julia Baldauf, Postgrad student with the on a LIEF grant with MDHS. Mulvaney lab visited schools in Victoria including two regional schools to help inspire students about nanotechnology and science more broadly. As part of her Ambassador role, Julia has visited four schools to talk about science, provide a short presentation on nanotech and its applications, and engage the students in some hands-on activities such as a spring that remembers its shape, magic sand and seeing different colours of nanocrystals.

12 School of Chemistry Annual Report 2012 ID Seed Grants for 2013 Research scholarship EMBO Travelling Interdisciplinary SEED gants were to PhD student Fellowship to PhD awarded to: Adlin Ramdzan, PhD student in the student • Dr Abigail Albright and Jonathon Kolev Group, was awarded the Dr Zalihe Hakki, PhD student in the White (Chemistry), U Ackermann Pamela Todd Research Scholarship Williams’ research group has been (Austin Health) and D Howell from St Hilda College. The Scholarship awarded a prestigious travelling (Florey) for ‘Development, synthesis, is awarded to a resident member fellowship from the European Molecular in vitro and in vivo evaluation of of the Senior Common Room who Biology Organization. The fellowship novel radiotracers for PET imaging demonstrates outstanding merit and will support travel expenses and living of ischemic Stroke’ promise in his or her scholarly discipline. costs for Zalihe to visit the laboratory of The Scholarship is awarded annually by Prof Gideon Davies at York University, • Prof Richard O’Hair (Chemistry), J the Council on the recommendation of United Kingdom and extend her studies Ziogas, C Wright and N Cranswick the Scholarship Committee. into the carbohydrate processing (Pharmacology), D Walker, A enzyme, endomannosidase. Tordesillas and M Small (Maths & Stats) for ‘Small Needles, Big Student prize Haystacks, and a Smart Comb: at Analytical & ASI Postdoctoral Integrating Network Theory and Environmental Fellowship to Vik Mass Spectrometry to Improve Chemistry meeting Dryza Pharmaceutical Development’ Edward Nagul from the Kolev Group Dr Viktoras Dryza has been awarded • Dr Craig Hutton, J Cottram was awarded a student prize for his oral a postdoctoral fellowship from the (Chemistry), K Barnham presentation at the 20th RACI Research Australian Solar Institute. His research (Neuroscience) for ‘Towards a and Development Topics Conference in project, entitled ‘Guiding the rational diagnostic agent for Alzheimer’s Analytical and Environmental Chemistry design of organic dye sensitisers for disease; detection of neurotoxic (December, Geelong). Eddie completed solar cell technologies’, aims to isolate amyloid peptides’ his MSc in 2012 and starts his PhD in organic dye molecules in the gas phase January next year. and investigate their spectroscopy and RACI Inorganic photophysics using advanced laser- Chemistry Group (VIC) Mick Moylan based techniques. Symposium comments on helium The School hosted the symposium again shortage McKelvie – new editor this year. The plenary lecture was given of Talanta Mick Moylan from the School of by Graham Ball (UNSW) who talked Chemistry was interviewed on Channel Assoc. Prof. Ian McElvie has been about multi-nuclear NMR spectroscopy 10 “The Project” regarding the helium appointed as an editor of the analytical and its use in characterising metal- shortage on Wed 19 Dec. chemistry journal, Talanta. alkane complexes. There were nine student talks from a mixture of students Chemistry textbook from RMIT, Monash, La Trobe and New Ultra-Compact UoM. The prize for best talk of the day NMR for Chemistry co-written by Uta went to Lea Fohlmeister (Monash); best Teaching Labs Wille now in Chinese poster prizes were awarded to Lachlan A high resolution benchtop NMR The market leading first year textbook McInnes (UoM), Sarah Laird (La Trobe) spectrometer has been purchased “Chemistry”, which was co-authored and Jamie Hicks (Monash). The prize for teaching our undergraduate by Assoc Prof Uta Wille (Publisher for the best question went to Peter Hall chemistry students. The bright red Wiley Australia), has been translated (a second year undergraduate student 43 MHz Magritek UCS is located in into Chinese and published through from UoM). the Level 3 teaching lab and was Wiley Asia. It is certainly not as glossy commissioned on 24 January 2013. and colourful as the English version, The ultra compactNMR spectrometer but good to see that Australian-made manufactured by Magritek Ltd, New teaching material is going onto the Zealand, was purchased through international market. Wilsmore and teaching support funding and will be trialled by our 3rd year CHEM30015 students this semester.

Photo courtesy Lachlan McInnes: Left Prof Anthony Wedd (President Inorganic Chemistry Group RACI Victorian Branch) and Dr Graham Ball )Plenary speaker from University of NSW.

www.chemistry.unimelb.edu.au 13 Societies

CHEMISTRY POSTGRADUATE SOCIETY In 2012 the CPS once again participated in organizing a “Career Panel Discussion” (in conjunction with BAMBI and President: Brian Adamson Bio21). Unlike 2011, the panel participants were not long into Vice President: Melina Glasson established careers but instead were recent graduates just Secretary: Alessandra Bestetti starting out, which together with improved publicity may have contributed to the better attendance. Treasurer: Nicholas Kirkwood General Committee members: There are plans to hold the usual ‘Welcome Back BBQ’, as well Chris Kingsbury, Luke Gamon, Sarah Jaber, Jessica Holmes, as a repeat of the popular Inter-Building Frisbee Challenge and Matt Greer, Sean Collins, Gautam Jain and Rob Johnston. it is anticipated that these events will go ahead under the new committee, to whom we wish all the best. President’s report In 2012 the CPS continued in its role of providing the School of Chemistry with a social forum, to complement the academic functions of the department. To this end CPS held social drinks on the first Friday of most months. In a similar pattern to 2011, these were well attended early on, but attendance slumped later in the year. With regard to other social events, the 2011 trivia night was a hard act to follow (with a record number of attendees). In 2012 numbers were reduced but the night was still a success and similarly the 2012 CPS Dinner was a smaller affair compared to the previous year. This is possibly due to the timing, being held during the exam period (when many people were busy with marking). Finally, however, the Cup Day BBQ was very well attended and considered a success. 2012 CPS Frisbee Challenge

MELBOURNE UNIVERSITY CHEMICAL SOCIETY (MUCS) Program of Events for 2012 May 9th October 3rd President: Prof Evan Bieske Dr Susan Rempe Sandia National Professor Annie Powell, Wilsmore Laboratory Fellow, Karlsruhe Institute of Secretary: Dr Paul Donnelly Ion Discrimination by Nanoscale Technology Treasurer: Dr Elizabeth Krenske Design Coordination chemistry - the next Student Representatives: Brian generation Adamson, Daniel Weber, Tom June 6th Whitwell, Julian Sanelli, Neville Dr Andi Horvath, Museum Victoria October 24th Coughlan. Mixing molecules and messages Professor Richard Robson, University and making it exothermic - Science of Melbourne Stranks Lecture. February 1st Communication Today Pre-organised molecular systems: Professor Helmut Schwarz, President exploratory studies spanning almost of the Alexander von Humboldt August 8th half a century at the Melbourne Foundation Professor Margaret Sheil, Provost, Chemistry School Chemistry with methane: concepts University of Melbourne rather than recipe What can we learn from Thomson, November 14th Heisenberg and Florey in framing Dr Chris Burns, Walter and Eliza Hall March 7th research and innovation policy. Institute of Medical Research Feutrill Professor Darryl Bornhop, Vanderbilt Lecture. University * Dr Valda McRae awarded Life The long crooked path of drug Membership of MUCS at 29th Lady A Universal Molecular Interaction discovery: Lessons from the discovery Masson Memorial Lecture on 8 Platform Based on Back-scattering and development of the kinase August 2012. Interferometry inhibitor, Momelotinib September 12th April 4th December 12th Professor Robert Continetti, Dr Niels Bassler, Aarhus University AGM & President’s lecture Wilsmore Fellow, University of Annihilating Cancer with Antimatter - California San Diego Science Fiction or Future to Come? Photodetachment of Molecular Anions

14 School of Chemistry Annual Report 2012 Chemistry building redevelopment

The School has being undergoing a major refurbishment program since 2008. This has included the development of new teaching laboratories on the 3 levels of the Chemistry West building, multipurpose teaching and student spaces on the ground level of Chemistry West and new research laboratories on each level of the Chemistry East Wing. Substantial new plant and services infrastructure has been put in place to support the new research and teaching spaces. Some $40 million dollars has been spent to date on these building works.

During 2012 the building works continued although at a slower pace as funding and planning processes permitted. The East Wing, Level 1 research laboratories for the Ashokkumar, Caruso and Grieser groups were completed during the year and occupied in March. Plans were also finalised for the remaining Level 2 research laboratories for the Kolev, Gee, Mulvaney and Best groups. This floor will include a large instrumentation laboratory for accommodating a range of spectroscopic and analytical equipment for use by researchers in the School. We expect funding to be approved and the laboratory to be completed during 2013. Late in the year some funding was provided for minor refurbishment of the Masson Lecture Theatre to allow it to meet comfort and EH&S requirements. These updates will be completed over the summer break and include cushion seating, handrails, painting and limitations to the seating capacity of the Theatre. The ‘heritage’ aspects and atmosphere of the Theatre have been retained. This will leave the redevelopment of office areas, other lecture theatres and general usage spaces to be completed in the final stages of the project. To ensure the Chemistry building continues to provide functional modern facilities for teaching and research, a Master Plan for the Chemistry building has been commissioned by Property and Campus Services and this will guide future usage and development plans. Ken Ghiggino (Chair, Chemistry Building Working Group)

Images courtesy of SKM: Completed level 1 research laboratories.

www.chemistry.unimelb.edu.au 15 Image created by Chris Ritchie, Colette Boskovic et al: A POM-based Coordination Polymer.

16 School of Chemistry Annual Report 2012 PRIZES AND AWARDS

Thomas Healey Award Agilent Award for The Stanley Harvey Excelllence Prize Stefanie Alexander, Robert Elliott & Alessandra Bestetti Stacey Rudd Michael Leeming T.W. Healy Award commemorates Awarded to a 3rd year student with the John Henry Harvey made a bequest to the distinguished career of Emeritus highest results undertaking a Chemistry award the Stanley Harvey Prize each year. Professor T.W. Healy, co-founder of research project with preference for This Prize is awarded to the winner of the Australian Colloid and Surface projects related to spectroscopy. the Professor Kernot Scholarship. Chemistry Student Conference, Dean of the Faculty of Science (1985-1990), JS Anderson Prize Dixon Research President of the Academic Board (1997-1998) and Professor of Physical Scholarship Tomer Simovich Chemistry until his retirement in 1998. Awarded to the student enrolled in Maoyuan Liu Awarded to students enrolled in at the Honours Year of a Science degree Awarded on the basis of fourth year least the second year of a postgraduate who is majoring in Chemistry and honours results to a student continuing degree by research in chemistry to who displays the greatest potential for on to a higher degree. assist the recipients to attend and research. present their research results at an International Conference (overseas or in Ronald Riseborough Fred Walker Prize Australia). Scholarship Edward Nagul Dwights Prize Stacey Rudd A donation was made in 1959 by James Clift Awarded to a 3rd year student for students and staff of Chemistry and a 4th year of study in Chemistry in from Mrs F. Riseborough to perpetuate Dwight Prize in 1st Year Chemistry preparation for a Master of Science. the memory of Ronald Riseborough. Awarded to an outstanding student in Awarded for the best fourth year 1st Year Chemistry going on to major in research report in Applied Chemistry. chemistry. James Cuming Memorial Scholarship Exhibition Prize Monica Elizabeth Major: Sarah Mann Reum Memorial Prize: Cheung Tung Shing Karen Steffi Minor: Cameron Ritichie Nicole J. Rijs Awarded to the student achieving the 2 scholarships (Major & Minor) were highest results in first year Chemistry. Donated in 1998 by family, friendzs and established for the study of Chemistry colleagues in memory of Dr Monica Does not have to be majoring in in its higher branches and to enable chemistry. Elizabeth Reum. Awarded to a PhD students to continue their studies after student who submits for assessment completion of the degree of Bachelor CA Taylor Prize an outstanding thesis in an area of of Science. Awarded to the top Faculty Organic Chemistry. The prize consists Honours students going into straight of a substantial monograph on some Joses Grady Nathanael Chemistry Honours. aspect of Organic Chemistry, with an Awarded to an outstanding second inscribed book-plate and remainder of year student who intends to major in Kernot Research the available income in cash. Chemistry. Scholarship

Huntsman Australia Michael Leeming Prize Open to candidates who have completed the BSc Honours course. Matthew Megens Awarded to a second year student proceeding to a major in chemistry in 3rd year.

www.chemistry.unimelb.edu.au 17 Chemistry Outreach Program

The Outreach Program in 2012 was awarded the Vice-Chancellor’s Engagement Excellence Award, recognising the success of the program and the effectiveness of our partnership with CSIRO Education in bringing chemistry education activities to schools. This year we worked with 20,403 students from Prep – Year 12, engaging these students in chemistry and supporting 1,076 of their teachers with interesting, curriculum relevant activities and professional development sessions.

It is particularly pleasing each year to Also in National Science Week, we host Year 12 students for our Analytical hosted Kevin Liu – a very keen food Instrument Workshops, where science writer – who took a group of students use the School of Chemistry teachers through the chemical changes laboratories to complete requirements in making a Whiskey Sour. And we for their end-of-year assessment. Many were particularly pleased to extend the of these students travel very long funding to develop A Scientific Entrée, distances for a taste of the University which will form a new set of classroom experience – groups from Sea Lake, activities on dairy science & technology Portland, Bairnsdale and Swan Hill were for Years 5-8. Six MSc students worked leaving school at the crack of dawn for on the project late in 2012 to develop a day trip to our laboratories. short instructional movies that will assist teachers with the theory and We were involved in some delicious practice of classroom cheesemaking. chemistry educational activities: we 2012 was certainly a thoroughly took chocolate chemistry to the Queen delicious year. Victoria Market (as guests of National Science Week) and to the Whittington Flamefest (hosted by RIAus) and to two groups of very keen 7-12 year old members of the Double Helix Science Club, going through the chemistry of chocolate making and accompanied by a chocolate sculptor.

18 School of Chemistry Annual Report 2012 ALUMNI FUNCTION 2012

Lady Masson Memorial Lecture, 8 August 2012 Alumni were invited to the 29th Lady Masson Lecture, which was given by Professor Margaret Sheil, Provost of the University of Melbourne, in the Masson Theatre on 8 August 2012. The lecture, entitled ‘What can we learn from Thomson, Heisenberg and Florey in framing research and innovation policy?,’ was well attended and stimulated much discussion. The Lady Masson Lecture was established in 1949 to honour Lady Masson, wife of Professor of Chemistry, Sir David Orme Masson. In addition to her unwavering support of her husband’s work, Lady Masson made a valuable contribution during World War Left to right: Provost Prof Margaret Sheil, Katherine Bassett, Prof Frances Separovic, I, and was awarded title of CBE in 1918. Ian Bassett (Grandson of Lady Masson) and This special lecture acknowledges her Dr Valda McRae. place in Australian history. More information on the chemistry Alumni functions can be obtained from the sites below. www.chemistry.unimelb.edu.au/ alumni-functions www.science.unimelb.edu.au/alumni

www.chemistry.unimelb.edu.au 19 SUBJECTS

First Year Second Year Third Year Director: Muthupandian Ashokkumar Director: Stephen Best Director: Uta Wille Deputy Director: Stephen Best

CHEM10003 Chemistry 1 CHEM20011 Environmental Chemistry CHEM30012 Analytical and M. Ashokkumar Spas Kolev Environmental Chemistry Spas Kolev CHEM10004 Chemistry 2 CHEM20018 Reactions and Synthesis M. Ashokkumar Stephen Best CHEM30013 Chemical Research Project CHEM10006 Chemistry for Biomedicine CHEM20019 Practical Chemistry Ken Ghiggino M. Ashokkumar Colette Boskovic CHEM30014 Specialised Topics in CHEM10007 Fundamentals of CHEM2002 Structure and Properties Chemistry B Chemistry Stephen Best Uta Wille M. Ashokkumar CHEM30015 Advanced Practical Chemistry Trevor Smith CHEM30016 Reactivity and Mechanism Uta Wille CHEM30017 Specialised Topics in Chemistry A Uta Wille

Higher Years Honours, PG Diploma in Chemistry, MSc Craig Hutton

20 School of Chemistry Annual Report 2012 Key Teaching and Learning Statistics

Research completions by Year SES The SES survey provides feedback from undergraduate and 30  PhD(AS) AS= Australian Subsidised Student  PhD(OF) OS= Overseas Full-Fee Students postgraduate coursework students on their perceptions of the  MPhil(AS) quality of teaching and learning experience for each subject in  PhD total  MPhil total which they are enrolled. 25 Students are asked whether they strongly agree (5); agree (4); agree nor disagree (3); disagree (2); or strongly disagree (1) with 10 questions regarding the subject. 20 Undergraduate students

5  Semester 1  Semester 2 15 4.5

4 10 3.5

3 5

2.5

0 2 2004 2005 2006 2007 2008 2009 2010 2011 2012 1.5

Teaching load 1

.5 600  2008  2009  0 2010 Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Q9 Q10  2011  2012 500 Graduate students

5  Semester 1  Semester 2 400 4.5

4 300 3.5

3 200

2.5

100 2

1.5

0 1

.5 UG (AF) UG (OF) UG (AS) HDR (OF) HDR (AS) UG TOTAL HDCW (AF) HDCW (OF) HDCW (AS) HDR TOTAL 0

HDCW TOTAL Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Q9 Q10

HDR (AS): Higher Degree Research/Australian Subsidised students HDR (OF): Higher Degree Research/Overseas Full-Fee students Q1: Intellectually Stimulating Q6: Useful assessment UG (AF): Undergraduate/Australian Full-Fee students Q2: Well coordinated Q7: Valuable feedback UG (OF): Undergraduate/Overseas Full-Fee students Q3: Learning resources Q8: New Ideas UG (AS): Undergraduate/Australian Subsidised students Q4: Well taught Q9: Apply to practice *EFTSL refers to Effective Full-Time Student loan Q5: High standard Q10: Learning community

www.chemistry.unimelb.edu.au 21 RESEARCH HIGHER DEGREE STUDENT COMPLETIONS

Jimmy Beenamma Ultrasonic nebulisation of aqueous surfactant systems

Gojko Buncic Synthesis and application of molecular probes for biologically important metal ions

Maryline Chee Lee Yin Chee Kimling Sol-gel template synthesis of porous metal oxide beads for sequestration of radionuclides

Kwun Lun Cho Development of superhydrophobic coatings

Lee Xin Chong Molecular characterization of copper Lauren Amy Palmer Andrew Tilley tolerance and resistance proteins and Nanobubbles: their role in the Confined conjugation MEH-PPV enzymes in gram-negative bacteria hydrophobic force and wetting derivatives: synthesis, photophysics behaviour of surfaces and energy transfer David Ian Fernandez Membrane interactions of Australian Nicole Joy Rijs David Chun-Ho Tso antimicrobial peptides Organometallic reagent ions with Towards the crystal structure of -silyl coinage metals: gas phase reactivity carbenium ions with higher electron Asimo Karnezis demand Gas & solution phase investigations into Zhenyu Shi the -, - and - effects of the group 14 Parallel DNA assembly by Keith Forrest White metals utilizing trialkyl-pyridinium ions recombination Porous and lightweight networks for hosting guest gas molecules Evelyn Laurens Alexander Michael St John Synthesis and biological analysis of Separation of uranium using polymer Yue Yue Zho novel Fluorine-18 positron emission inclusion membranes Effect of sonication treatment on the tomography (PET) imaging agents for physico-chemical properties of starch- hypoxic tissues in tumours Jeremy Chin-Siong Tan based suspensions The synthesis of bicyclic lactams using Harvey Cong Li the concept of self-terminating radical Adventures with peroxyl radicals as cyclisations precursors for -oxo carbenes and related reactive intermediates Phei Hsin Tan Towards the synthesis of multipotent Sin Chun Lim antihypertensive and antioxidant Metal complexes for diagnostic imaging nitroxide containing sartans of cerebral perfusion and amyloid-beta plaques in Alzheimer’s disease

22 School of Chemistry Annual Report 2012 Research funding 2012

The School of Chemistry receives research funding and grants from a variety of sources, including the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) and other Government and Industry bodies. We also have a wide range of sponsors who offer prizes and scholarships and collaborate on research and infrastructure projects.

RESEARCH Dr Paul Donnelly Award to Rachel Caruso; International PERFORMANCE FOR 2012 Copper complexes for the diagnostic Society of Magnetic Resonance imaging of Alzheimer’s disease (ISMAR) Fellow to Frances Separovic; The School of Chemistry at the Tall Poppy Awards to Chemistry Copper and gallium radiopharmaceuticals University of Melbourne is one of graduates Georgina Such and Colin for the diagnosis and therapy of cancer Australia’s leading research centres Scholes; Staff Engagement Excellence in the chemical sciences, with an Modulating cellular copper levels to Award to Mick Moylan; Inspiring excellent international research prevent the effects of excitotoxicity Australia Grant to Renee Beale; reputation and an outstanding record in neurodegenerative diseases (with Mitzutani Foundation for Glycoscience in attracting research funding. The Pathology) grant to Spencer Williams; Go8 School performed strongly in nationally Australia- Germany Research Dr John Gehman & competitive grant schemes with new Cooperation Award to Uta Wille; three Prof. Frances Separovic successful ARC Discovery Projects, Melbourne Research Interdisciplinary Advanced biophysical characterisation Linkage, Future Fellowships and LIEF Seed Funding grants; Dyason Award centre (with RMIT) equipment infrastructure grants, and to Mark Rizzacasa; Early Career Award NHMRC Project as well as three ID Assoc. Prof. Craig Hutton to Chris Ritchie; ASI Postdoctoral Seed Grants. Wallace Wong and David Solid phase synthesis of side-chain cross- Fellowship to Viktoras Dryza; McKenzie Jones were awarded $1.2M as part linked peptide oligomers Fellowships to Marco Lista and Willem of the Australian Solar Institute (ASI) van der Heuvel; and Victorian Young Australia- Germany Collaborative Solar Prof. Spas Kolev Nanotechnology Ambassador Award to The pollution potential of mercury in R&D fund for their project “Enhancing Julia Baldauf. efficiencies in printed solar cells by legacy biosolids and possibilities for its controlling morphology development”. minimisation by phytoremediation and In 2012 The School of Chemistry held phytostabilisation approaches and participated in many conferences The School hosts the ARC Centre of and events, some of which are: Excellence for Free Radical Chemistry Prof. Robert Lamb International Chemistry Conference Tunable antifouling behaviour on rough and Biotechnology and is a participant on Organic Synthesis (ICOS); The surfaces in the ARC Centre of Excellence in Lady Masson Memorial Lecture; RACI Coherent X-Ray Science. The School is Prof. Frances Separovic Inorganic Chemistry Group (VIC) a major part of the Bio21 Institute and A 700 MHz Nuclear Magnetic Resonance Symposium; and the Miegunyah Public has strong links with the Melbourne (NMR) spectrometer for the Melbourne Lecture. The School also co-sponsored Materials Institute, Centre for Aquatic Biomolecular NMR Network: A high the Materials of Life Symposium held at Pollution Identification & Management, throughput resource (with Biochemistry) the Melbourne Brain Centre Auditorium and the Particulate Fluids and and the Australian Workshop for Processing Centre. The Surface and Prof. Anthony Wedd & Chemical Biology at the Bio21 Institute. Chemical Analysis Network (SCAN) Dr Paul Donnelly is a School of Chemistry facility for Redox sulphur chemistry in copper materials and environmental analysis nutrition connecting industry with University Assoc. Prof. Spencer Williams researchers. Several academic staff Dissecting catalysis and inhibition of a are also members of the Australian unique endo-acting mannose-processing Synchrotron Sciences Network. glycosidase The School of Chemistry was awarded The quality of our researchers is several new ARC and NHMRC projects recognized by awards for research commencing in 2012, including: excellence including: Royal Medal to Assoc. Prof. Brendan Abrahams & Andrew Holmes; AAS Fellowship to Prof. Richard Robson Frances Separovic; the Dean’s Award New molecular architectures: synthesis, for Excellence in Research to Paul structure and properties Donnelly; Selby Research Award to Angus Gray-Weale; Gordon Conference Prof. Evan Bieske Award and Young Investigator Award Laser spectroscopy of functional to Paul Donnelly; Australian Leadership molecules

www.chemistry.unimelb.edu.au 23 24 School of Chemistry Annual Report 2012 ARC CENTRE OF EXCELLENCE FOR FREE RADICAL CHEMISTRY AND BIOTECHNOLOGY

The ARC Centre of Excellence for Free Radical Chemistry and Biotechnology (The Free Radical Centre) had an eventful year continuing to be well represented in the international radical community. There were symposia dedicated to the lives of free radical greats, and international conferences showcasing the latest in research developments.

Outcomes were highlighted through a number of press releases, including television and radio, and through podcasts. There were numerous achievements by individuals and by teams, and through dynamic community engagement. Several research initiatives are positioned for sustainability beyond the current ARC Centre grant, as evidenced by cross- node and multi investigator outputs, and the camaraderie shown by Centre members in general. It is clear that The Free Radical Centre is contributing strongly to the international free radical scene through multiple articles in top peer-reviewed journals and through strong presence Left to right: Artist Steve Lopez, Centre Manager Dr Linda Feketeora and artist Peter Sharp. and participation at international conferences. Research highlights deliberated on student oral and poster Radical Centre has given birth to a for the year include contributions presentation prizes. number of activities that will spin to improving the efficiency of dye- out with healthy lives of their own, sensitised solar cells and the discovery Through Renee Beale’s leadership, The sustained through a number of key of new fats and lipids in the human Free Radical Centre made impressive opportunities. The ARC Centre of lens with links to disease, among contributions to Community Awareness Excellence for Free Radical Chemistry many others. Centre research was also in 2012. The Centre sponsored several and Biotechnology was impressive published in Nature and contributed major events that included the Radical during 2012 and congratulations go to five chapters to The Encyclopedia Wine and Chocolate event at the each of the Centre’s Members for their of Radicals in Chemistry, Biology Western Australian Museum, the contributions. and Materials, 100 peer-reviewed Science Discovery Expo in the Bio21 journal articles and 209 conference Institute, The Market of the Minds in presentations. In addition, Centre City Square Melbourne, and Radical members also contributed to a book, Beer at the Brewery in Wollongong. 6 book chapters, a patent application, With the award of an Inspiring Australia: and featured on 286 occasions in the Unlocking Australia’s Potential grant popular media, including 16 radio or from DIISRTE, the Centre, together with television interviews. its partners, embarked on a programme to communicate information about In late November, 75 Centre members free radicals through the use of art. and invited guests met at the Following on from Concept Radical Innovation Campus of the University in 2011, a number of high-profile of Wollongong for the annual Centre Australian artists become artists-in- “Carnival” and were treated to a residence under the guise of a visionary healthy array of student and postdoc programme called Insight Radical. This presentations. Derek Pratt from is the largest outreach project embarked Ottawa made for an impressive plenary upon by The Free Radical Centre and will speaker, while Michelle Coote from culminate with an exhibition of works in ANU and Mike Davies from the Heart London during 2013. Research Institute rounded out the programme with keynote lectures. As we enter the final year of ARC An independent panel of judges funding, it is clear that The Free

www.chemistry.unimelb.edu.au 25 Conferences 2012

Dr Sneha Abraham October International Conference on Emerging Advanced Brisbane QLD Nanomaterials (ICEAN) Prof Muthupandian July 13th Meeting of the European Society of Sonochemistry Lviv, Ukraine Ashokkumar October International Nonthermal Food Processing Workshop Melbourne VIC FIESTA 2012 Prof Evan Bieske February Gordon Research Conference Ventura USA April Workshop on Chemical Dynamics and Molecular Taipei Taiwn Spectroscopy April 16th Eastern Asian Workshop on Chemical Dynamics Hsinchu Taiwan November Asian International Symposium of Atomic and Molecular Taipei Taiwan Physics Dr Colette Boskovic July International Conference on Molecular Materials Barcelona Spain (MOLMAT) October International Conference on Molecule-Based Magnets Orlando USA (ICMM) November Italian-Australian Workshop on Nanostructured Materials Canberra ACT for Magnetic and Spintronic Devices Assoc Prof Rachel Caruso February 7th Annual International Electromaterials Science Geelong VIC Symposium March 243rd ACS National Meeting San Diego USA July 1st International Conference on BioNano Innovation Brisbane QLD October 7th Aceanian Conference on Dye-Sensitized and Organic Taipei Taiwan Solar Cells Dr Maryline Chee Kimling October International Conference on Emerging Advanced Brisbane QLD Nanomaterials Mrs Penny Commons February Science Teachers Association of Victoria Chemistry Melbourne VIC Conference November Chemistry Education Association November Lectures Melbourne VIC Dr Augustine Doronila January After mining workshop: Improving Training of Baguio City, Environmental Scientists and Developing Management Philipines Strategies for Community-based Ecological Restoration Projects of Mined Lands February 1st Indonesian International Conference on Environmental, Malang Indonesia Socio-economic, and Health Impacts of Artisanal and Small Scale Mining July 4th International Congress on Arsenic in the Environment Cairns QLD November Arbuscular Mycorrhizal Fungi (AMF) and Biosolids Enhance Melbourne VIC the Growth of Native Australian Grasses on Sulphidic Gold Mine Tailings

November 1st Conference of the Society for Ecological Restoration Stawell VIC Australasia Dr Paul Donnelly June Young Investigator Award’ Speaker: Gordon Research New Hampshire Conference on Metals in Medicine USA November 6th Asian Bioinorganic Chemistry Conference Hong Kong China

26 School of Chemistry Annual Report 2012 Dr Linda Feketeova May 51st Annual Meeting of Particle Therapy Co-Operative Seoul Korea Group (PTCOG51) June Workshop on Solid State Dosimetry in Neutron and Ion Mainz Germany Radiation Fields September 19th International Mass Spectrometry Conference Kyoto Japan (IMSC2012 & The 3rd Asian and Oceanic Mass Spectrometry Conference (AOMSC-3) Dr Maria Ines Gameiro September Polymer inclusion membranes: Concept and applications. London UK Sa Almeida Assoc Prof Michelle Gee September Fluoro 2012: Use of optical spectroscopy and microscopy Sydney NSW techniques in biological and biomedical research December AuPS/PSNZ/ASB Joint Meeting Sydney NSW Dr John Gehman February US Biophysical Society Meeting San Diego USA Professor Ken Ghiggino September 3rd International Organic Excitonic Solar Cell Conference Brisbane QLD (IOESC:2012) November 7th Asian Photochemistry Conference (APC 2012) Osaka Japan Dr Angus Gray-Weale October 10th Asian International Seminar on Atomic and Molecular Taipei Taiwan Physics October 222nd Electrochemical Society Honolulu Hawaii Professor Andrew Holmes February Newton Abraham Public Lecture Oxford UK February John B Goodenough Award Lecture Birmingham UK April Joint Chinese Chemical Society-RSC Symposium Chengdu China June IUPAC World Polymer Congress Blacksburg USA Aug 244th ACS National Meeting Division of Energy and Fuel Philadelphia USA Cells November H Dudley Wright Foundation Colloquium Lecturer Geneva Switzerland Dr Sonia Horvat July 11th International Symposium on Organic Free Radicals Bern Switzerland Assoc Prof Craig Hutton February Gordon Research Conference on Chemistry & Biology of Ventura USA Peptides July 19th International Conference on Organic Synthesis Melbourne VIC (ICOS19), in conjunction with the 24th Royal Australian Chemical Institute Organic Conference (RACIOC24) Dr David Jones October IWAMSN 2012 Ha Long Vietnam December 50th Annual Australian Solar Council (AuSES) Melbourne VIC Dr George Khairallah May 60th American Society for Mass Spectrometry (ASMS) Vancouver Canada Conference September 19th International Mass Spectrometry Conference Kyoto Japan Assoc Prof Spas Kolev February Conference on Emerging Trends in Separation Science and Mumbai India Technology April Asia-Pacific Conference on Analytical Sciences Manila Phillippines July 7th Australasian Membrane Society Conference Busan South Korea September 1st International Conference of the Indonesian Chemical Malang Indonesia Society September 12th International Conference on Flow Analysis Thessaloniki Greece December R&D Topics Conference Melbourne VIC

www.chemistry.unimelb.edu.au 27 Professor Robert Lamb April Asia Pacific Analytical Sciences Manila Phillippines May Canadian Synchrotron Conference Saskatoon Canada June 16th International Congress on Marine Corrosion and Seattle USA Fouling July Synchrotron Radiation Instrumentation SRIIO October Forum on Advanced Materials Research Chengdu China Mr Mick Moylan November STAVON Melbourne VIC November CEA November Lectures Melbourne VIC Professor Paul Mulvaney May NaNaX5 Malaga Spain May CSIRO Workshop on Sol-Gel Electronics Melbourne VIC June Yamada Conference on Photoenhanced Energy Conversion Tokyo Japan in Nanostructed Systems June Gordon Conference on Metal Nanoparticles Easton USA July OSNOS Conference Dresden Germany October 4th NanoCon Conference Brno Czech Republic Professor Richard O’Hair May 60th American Society for Mass Spectrometry (ASMS) Vancouver Canada Conference June 34th Reaction Mechanisms Conference September 19th International Mass Spectrometry Conference Kyoto Japan Dr Brett Paterson September 40th International Conference on Coordination Chemistry Valencia Spain (ICCC40) Dr Christopher Ritchie November Frontiers in Metal Oxide Cluster Science Lanzaraote Spain Professor Mark Rizzacasa February Zing Natural Products Conference Lanzaraote Spain July 19th IUPAC International Conference on Organic Melbourne VIC Synthesis/24th RACI Organic Division Conference September 1st International Symposium on Natural Product Synthesis Chongqing China and Process Methods for Drug Manufacture Dr Marc-Antoine Sani December Australian Society of Biophysics Sydney NSW Professor Carl Schiesser March 243rd American Chemical Society National Meeting and San Diego USA Exposition June 25th International Symposium on the Organic Chemistry of Czestochowa Sulfur Poland June Workshop on Solid State Dosimetry in Neutron and Ion Mainz Germany Radiation Fields July 11th International Symposium on Organic Free Radicals Berne Switzerland August 244th American Chemical Society Nation Meeting and Philadelphia USA Exposition November 19th Annual Meeting of the Society for Free Radical San Diego USA Biology and Medicine December IV Encontro Sobre Selenio e Telurio Brasil Torres Brazil December Intramolecular Homolytic Substitution of Seleninates - Torres Brazil A Computational Study Professor Frances February 56th Biophysical Society Meeting San Diego USA Separovic May Science at the Shine Dome Canberra ACT July EuroMar 2012 Magnetic Resonance Conference Dublin Ireland November Lipid-protein interactions in membranes: implications for Hyderabad India health and disease December 36th Annual Meeting of the Australian Society for Sydney NSW Biophysics

28 School of Chemistry Annual Report 2012 Assoc Prof Trevor Smith January Molecular Materials Meeting (M3) An international Biopolis Singapore coference on Frontiers in Materials Science, Chemistry & Physics April Focus on Microscopy 2012 Singapore June Workshop on Optical Microscopy in Life Sciences Wuhan China July Ultrafast Phenomena Lausanne Switzerland July XXIV IUPAC Symposium on Photochemistry Coimbra Portugal September Japanese Photochemistry Association Annual Meeting on Tokyo Japan Photochemistry 2012 October 2012 Symposium on Recent Development of Taipei Taiwan Nanomaterials: Structures, Dynamics and Applications Dr Alesssandro Soncini June Accurate methods for accurate properties: a conference to Zurich Switzerland mark the 60th birthday of Peter R. Taylor November ANSTO- Italian-Australian Workshop on Nanostructured Canberra ACT Materials for Magnetic and Spintronic Devices Professor Peter Taylor May Strongly correlated systems: a conference in honour of the Palermo Italy 60th birthday of Per-Aake Malmqvist June Accurate methods for accurate properties: a conference to Zurich Switzerland mark the 60th birthday of Peter R. Taylor November Supercomputing 2012 Salt Lake City USA Assoc Prof Peter Tregloan May LAK12 - Second International Conference on Learning Vancouver Canada Analytics and Knowledge September Thinking through Drawing London UK November Southern Solar Flare, Society for Learning Analytics Sydney NSW Research Professor John Webb March International Conference on Technology Education and Valencia Spain Development INTED - 6 May Rabindranath Tagore. A myriad minded genius Perth WA September Towards a better innovation ecosystem New Delhi India November CSIRO - India Workshop on Collaboration Canberra ACT Professor Anthony Wedd January Meeting of International Society for Zinc Biology Melbourne VIC July Biometals 2012 Brussels Belgium November 6th Asian Conference on Biological Inorgaic Chemistry Hong Kong China November Inorganic Chemistry Symposium of RACI Victorian Branch Melbourne VIC Assoc Prof Jonathan White December Australia Asia Crystallography Conference Adelaide SA Dr Uta Wille July ICOS19/RACIOC24 Melbourne VIC December 36th Annual Synthesis Symposium Melbourne VIC Dr Spencer Williams July 27th International Carbohydrate Symposium Madrid Spain July International Conference on Organic Synthesis, ICOS19 Melbourne VIC Dr Wallace Wong July International Conference on Synthetic Metals Atlanta USA September International Conference on Organic and Excitonic Solar Brisbane QLD Cells Dr Alex Wu June 16th International Congress on Marine Corrosion and Seattle USA Fouling Dr Xiao Zhiguang January International Society for Zinc Biology 2012 Conference Melbourne VIC November Australian Conference of Free Radical & Metal Biology 2012 Brisbane QLD

www.chemistry.unimelb.edu.au 29 Image created by Brendan Abrahams: A porous coordination polymer in which calcium and tin centres are linked by bridging ligands.

30 School of Chemistry Annual Report 2012 INORGANIC AND ANALYTICAL CHEMISTRY SEMINAR PROGRAM

Coordinator: Professor Tony Wedd E: [email protected]

13 February 17 April 25 July 4 September Dr Tom Faust Ms Youngsoo Choo Professor Rob Deeth Dr Jason Dutton University of Manchester University of Melbourne University of Warwick La Trobe University “Molecular Rings for Quantum “Polymer Inclusion Membranes “Transition Metal “Theoretical and Synthetic Information Processing” for the Clean-up of Process Computational Chemistry: Investigations of Main Group Water from Gold Mining Using Beyond DFT” Compounds in Zero Oxidation 6 March Thiocyanate and Cyanide States” Extractants” Dr Masumi Itazaki 31 July Osaka City University Dr Yanyan Mulyana 11 September 24 April Ms Ya Ya Bonggotgetsakul “A Versatile Iron Complex Monash University Catalyzing C-CN Bond Prof Irene Yarovsky “Ruthenium Complexes: University of Melbourne Cleavage and C-Si and C-Ge RMIT University From Bio-Inspired Energetic “Paper-based Devices for Bond Formation” “Nano-materials for biomedical Materials” Analysis in Life Science” Applications: Exploring the 13 March Role of Protein-Solid Surface 7 August 18 September Interactions” Prof Philip Marriot Professor Stuart Batten Ms Hannah Alcantara Monash University University of Melbourne Monash University 1 May “Earth, Wind, Fire & Water – “Beautiful Structures I Have “Plants Under Stress? Aspirin is Dr Anne Richards Separation & Discovery “ met: a Tour of Attractive the Answer!” La Trobe University Coordination Polymers” 20 March “Design and Synthesis 2 October of Molecular Cages and Dr Chris Sumby 14 August Professor Annie Powell Polymers” University of Adelaide Dr Anthony O’Mullane University of Karlsruhe RMIT University “Incorporating Additional 8 May “Supramolecular Approaches Functionality into Porous “Metal Nanoparticle- to Enhancing Single-Molecule Robert Elliott Coordination Polymers” decorated TCNQ-based Magnet Properties” University of Melbourne Coordination Polymers as both 27 March “Rocket Fuels” Heterogeneous and Photo- 9 October catalysts” Dr Max Massi Matthew Wooley Ms Yuki O’Bryan Curtin University University of Melbourne 21 August University of Melbourne “Application of phosphorescent “Real-time Monitoring of Drug “Chemistry of Metallic High Dr Paul Frances lanthanoid and transition metal Temperature Superconductors” Delivery Systems” complexes in materials and Deakin University life science” 15 May “Chemical Reactions That Ms Adlin Ramdzan Produce Light: New insights University of Melbourne Dr Andy Ohlin 3 April and Analytical Applications” “Baking Classes with a Monash University Dr William Donald Master Chemist: The Use of “Aqueous Reactions of Metal University of Melbourne 28 August Ultrasonics in Cake-Making” Oxide Clusters” Dr Helen Maynard-Casely “The Mass Spectrometer as a Chemical Laboratory- Australian Synchrotron Absolute Electrochemistry, Ion 22 May “In situ Studies with Fluorescence, and Biomimetic Prof Peter Junk Synchrotron Powder Chemistry” Monash University Diffraction: Applications on “New metal based syntheses in Earth and Beyond” Prof Anthony Wedd rare earth chemistry” University of Melbourne “From Literature: Remarkable Metallo-Protein Structures”

www.chemistry.unimelb.edu.au 31 Image created by Mark Rizzacasa: A rottnestol molecule isolated from a sponge collected from water around Rottnest Island Western Australia. Artwork: Jo Dalvern

32 School of Chemistry Annual Report 2012 ORGANIC CHEMISTRY SEMINAR PROGRAM

Coordinator: Dr Wallace Wong E: [email protected]

17 February 22 May 31 August 23 October Prof Ian Paterson Professor Robert Flowers Professor Yongfang Li Assoc Prof Derek Pratt University of Cambridge Lehigh University Institute of Chemistry, University of Ottawa Chinese Academy of Sciences “Progress, Problems and “Give or Take an Electron: “The Old and the New in Serendipity in Polyketide Mechanistic Studies of Single “Photovoltaic Materials and Cholesterol Oxidation and the Synthesis” Electron Transfer in Important Devices for High Efficiency Role of Sulfenic Acids in the Synthetic Reactions” Polymer Solar Cells” Antioxidant Activity of Garlic and 24 February Related Alliums” Dr Marcus Baumann 1 June 7 September 26 October University of California Dr Luke Hunter Paul Sylvester “Total synthesis of University of New South University of Melbourne Dr Jamie Simpson Monash University natural and unnatural Wales “Profluorescent Nitroxides and epidithiodiketopiperazines “Fluorinated amino acids: the Coil Coating Industry” – PhD “The big and the small of it: lipid and their evaluation as potent building blocks for the synthesis swansong prodrugs and fragment-based anticancer compounds” of shape-controlled bioactive lead design” 2 March peptides” 14 September 2 November Marilena Giarrusso Professor Dale Ward Dr Guillaume Lessene 15 June University of Melbourne University of Saskatchewan Professor Steen Brøndsted Walter and Eliza Hall Institute “Towards Novel Fluorescent “Synthetic Studies on Marine Nielsen Angiotensin AT1 Receptor “Discovery of small molecules Polypropionates” Aarhus University Antagonists” – PhD swansong interfering with BCL-2 driven cell 9 March “Electron-induced dissociation survival pathway” of peptide cations – by collisions 21 September Prof Mukundan Thelakkat 9 November or light” Mohammad Haskali University of Bayreuth University of Melbourne Aaron Song “Understanding, controlling and 22 June University of Melbourne “18-Fluorine radiolabelled tuning morphology in polymer Dr Anastasios Polyzos peptides for PET imaging of “Functional Conjugated Polymers and hybrid solar cells” CSIRO cancer” – PhD swansong – From Design to Devices” – PhD 30 March “Flow Chemistry: An Enabling swansong Technology for Chemical 28 September Roland Fitzner 15 November Synthesis” Dr David Lupton University of Ulm Monash University Linda Chan “Dicyanovinyl-capped 10 July University of Melbourne “Acyl anion free N-heterocyclic oligothiophene donor materials Professor Minoru Isobe carbine organocatalysis” “Structure-function relationship for molecular organic solar cells” National Tsing Hua University studies on human relaxin-2 “Marine Bioluminescence 8 October leading to the development 13 April of novel receptor-selective Chemistry of Photoprotein- Rohan Williams Dr Bruce Cornell Coelenterazine System” analogues” – PhD Completion Surgical Diagnostics Pty Ltd University of Melbourne Seminar Sydney 10 August “Investigating the mechanism of mannosidases: synthesis of 23 November “Ligand and voltage gated Dr Balaji Purushothaman inhibitors and substrates” ion channel measurements in University of Melbourne Prof Rainer Herges tethered membranes by AC and University of Kiel “Stabilizing Reactive Acenes for DC impedance spectroscopy” 12 October Device Applications” “Spin Switching in Isolated Tu Anh Tran Molecules: Molecular Machines 27 April 17 August University of Melbourne in Medical Imaging” Professor Shelli R McAlpine Dr Henk Dam “Homolytic Addition Reactions University of New South of Acyl Radicals with Triple Bond 26 November University of Melbourne Wales Systems” – PhD swansong Dr Paul C. Taylor “Polyrotaxanes as component for University of Warwick “Macrocycles: the perfect tools drug delivery systems” to explore protein function” 19 October “Uncovering Interactions 27 August Dr Rohan John Kumar between Drugs and Hormones 4 May University of Melbourne and their Protein Targets Professor Gregory A. Weiss Dr Fabrice Denes “Self-Assembly of Organic using the Magic Tag Chemical University of California University of Nantes Semiconductors for Organic Genomics Tool” “Exploring Biology and Photovoltaic Applications” “Alpha-Bromo-Aluminum Acetals Chemistry with Nanometer-Scale 30 November in Radical Chemistry: Scope and Electronics” Limitation” Jesse Barton University of Melbourne “Diketopyrrolopyrroles for Solar Cells” – PhD Completion Seminar

www.chemistry.unimelb.edu.au 33 Photo courtesy of Alex Duan: “Scratch the surface-X-ray photoelectron spectrometer from Lamb Lab.

34 School of Chemistry Annual Report 2012 PHYSICAL CHEMISTRY SEMINAR PROGRAM

Coordinator: Dr Alessandro Soncini E: [email protected]

13 March 25 June 19 October 5 December Dr Christian Evenhuis Dr Chris McNeill Dr Rohan John Kumar Dr Asaph Widmer-Cooper Department of Chemistry Department of Materials University of Melbourne School of Chemistry, and The PULSE Institute, Engineering, Monash University of Sydney Stanford University University “Self-Assembly of Organic Semiconductors for Organic “Directing the assembly of “Simulating Excited State “Soft X-ray Characterisation of Photovoltaic Applications” nanoparticles for plasmonic Dynamics” Organic Semiconductor Films” and solar energy applications: 26 October insights from simulations” 23 April 20 July Professor Marco Affronte Assoc Prof Timothy Schmidt Professor William M. Department of Physics, 10 December School of Chemistry, Jackson University of Modena, and Professor Dan Li University of Sydney Department of Chemistry, CNR Nanoscience Institute Department of Materials University of California Davis S3 Engineering, Monash “Photonic Alchemy: Turning University Red into Gold for Improved “Photodissociation of High “Molecular nanoMagnets for Solar Energy Conversion” energy states of N2 and CO refrigeration and spintronics” “Colloidal approach to using two tunable VUV sources graphene-based materials” 9 May and a time-sliced velocity-map 5 November Dr A. Alia ion imaging apparatus” Dr Gallo Soler-Illia, Wilsmore 12 December Leiden Institute of Fellow Benjamin Robotham Chemistry, Solid State NMR, 27 August Gerencia Quimica, Comision School of Chemistry, University of Leiden Leena Chandhi Nacional de Energia Atomica University of Melbourne Dharmarathne (CNEA), Argentina “Direct access to the heart of School of Chemistry, “Photochemistry of the photsosystem II membrane University of Melbourne “Designed mesoporous Photosynthetic Mimics”, PhD protein complex by Photo- thin films: Architecture and Swansong CIDNP Solid State NMR” “Ultrasound Initiated Electron decoration at the nanoscale” Transfer to Colloidal Micro 17 December 14 May Electrodes”, PhD Swangsong 19 November Steven Barrow Dr Seth Olsen Dr Ekaterina Pas, 2011 RACI Bio21 and School of University of Queensland 1 October Physical Chemistry Division Chemistry, University of Professor Thomas M. Lectureship Award Melbourne “The Chemistry and Physics of Klapötke School of Chemistry, Charge-Resonance” Department of Chemistry, Monash University “Single Particle Spectroscopy Energetic Materials of Self-Assembled Gold 21 May Research, LMU Munich “First Principles approaches to Nanostructures”, PhD Dr David Huang studying ionic liquids” Swansong School of Chemistry and “Energetic Materials Research Physics, University of at LMU Munich” 26 November Adelaide Emma Hooley 8 October School of Chemistry, “Slip, ion specificity, and other Dr Michelle J. S. Spencer University of Melbourne molecular effects in surface- Department of Chemistry, La driven flow for microfluidics and Trobe Institute for Molecular “Single molecule spectroscopy nanofluidic energy conversion” Science, La Trobe University of conjugated polymers”, PhD Swansong 28 May “Nanomaterials for Sensors, Assoc Prof Toby Allen Electronic Devices and 3 December School of Applied Sciences, Batteries” Julia Baldauf RMIT Bio21 and School of 15 October Chemistry, University of “Uncovering membrane charge Nicholas Tse Melbourne transport mechanisms” CSIRO and School of Chemistry, University of “The effects of external fields 18 June Melbourne on the optical properties of Dr Jean Wyer nanocrystals”, PhD Swansong Department of Physics “Nanostructured and Astronomy, Aarhus nanoparticulates for the use University as medical contrast”, PhD Swangsong “Spectroscopy of isolated heme ions in vacuo”

www.chemistry.unimelb.edu.au 35 PUBLICATIONS 2012

Abrahams BF, Abrahams CT, Haywood Chandrapala JJ, Oliver C, Kentish SE & Mohd Yusof NS, Khan MN & MG, Hudson TA, Moubaraki B, Murray KS Ashokkumar M. 2012. Ultrasonics in Ashokkumar M. 2012. Characterization & Robson R. 2012. 3d-Metal derivatives food processing - Food quality assurance of the structural transitions in CTAB of the [Cu(I)(SO3)4]7- ion: structure and and food safety. Trends in Food Science micelles using fluorescein isothiocyanate. magnetism. Dalton Transactions. 41 : and Technology. 26 : 88-98. Journal of Physical Chemistry C. 116 : 4091-4099. 15019-15027. Chandrapala JJ, Oliver C, Kentish SE Abrahams BF, Bond AM, Thanh HL, & Ashokkumar M. 2012. Ultrasonics Raj, Anandan, Solomon, Venuvanalingam, Mccormick L, Nafady A, Robson R & in food processing. Ultrasonics Iyer & Ashokkumar M. 2012. Synthesis Nguyen V. 2012. Voltammetric reduction Sonochemistry. 19 : 975-983. of conjugated perylene diimide- and re-oxidation of solid coordination based copolymer with 5,5 ‘-bis(4- Chandrapala JJ, Oliver C, Kentish SE polymers of dihydroxybenzoquinone. aminophenyl)-2-2 ‘-bifuryl moiety as an & Ashokkumar M. 2012. Use of Chemical Communications. 48 : 11422- active material for organic photovoltaics. power ultrasound to improve extraction 11424. J. Photochemistry & Photobiology A and modify phase transitions in food -Chemistry. 247 : 52-62. Abrahams BF, Elliott R, Hudson TA & processing. Food Reviews International. 29 Robson R. 2012. A new type of 3D [(M-II) : 67-91. Raj MR, Arun K, Ashokkumar M & (2)(TCNQ(-II))(3)](2-) coordination network Anandan S. 2012. Ultrasound-assisted Chandrapala JJ, Zisu B, Kentish SE & with spacious channels of hexagonal ullmann reaction of alkyl and aromatic Ashokkumar M. 2012. The effects cross-section generated from TCNQH(2). amines with substituted benzoic of high-intensity ultrasound on the CrystEngComm. 14 : 351-354. acids using copper catalyst. Organic structural and functional properties of Preparations & Procedures International. Chen X, Li H-X, Zhang Z-Y, Zhao W, Lang -lactalbumin, -lactoglobulin and their 44 : 271-280. J-P & Abrahams BF. 2012. Activation mixtures. Food Research International. 48 and amplification of the third-order NLO : 940-943. Shanmugam A, Chandrapala JJ & and luminescent responses of a precursor Ashokkumar M. 2012. The effect of Collis J, Leong T, Novell A, Ashokkumar cluster by a supramolecular approach. ultrasound on the physical and functional M, Kentish SE, Bouakaz A, Ooi AS & Chemical Communications. 48 : 4480- properties of skim milk. Innovative Food Manasseh R. 2012. Effect of surfactant 4482. Science & Emerging Technologies. 16 : type on microstreaming velocities around 251-258. Hawes CS, Babarao R, Hill MR, White microbubbles. In Ohl CD, Klaseboer E, KF, Abrahams BF & Kruger PE. 2012. Ohl SW, Gong SW & Khoo BC(eds), Proc. Son Y, Lim M, Khim J & Ashokkumar Hysteretic carbon dioxide sorption in a 8th International Symposium on Cavitation. M. 2012. Acoustic emission spectra novel copper(II)-indazole-carboxylate 1-4. Singapore: CAV 2012 Organizers & and sonochemical activity in a 36 kHz porous coordination polymer. Chemical Research Publishing Services. sonoreactor. Ultrasonics Sonochemistry. Communications. 48 : 11558 -11560. 19 : 16-21. Fernandez Rivas D, Ashokkumar Anandan, Lee, Yang, Ashokkumar M M, Leong T, Yasui K, Tuziuti T, Son Y, Lim M, Khim J & Ashokkumar & Wu . 2012. Sonochemical synthesis Kentish SE, Lohse D & Gardeniers M. 2012. Attenuation of UV light in large- of Bi2CuO4 nanoparticles for catalytic H. 2012. Sonoluminescence and scale sonophotocatalytic reactors: The degradation of nonylphenol ethoxylate. sonochemiluminescence from a effects of ultrasound irradiation and TiO2 Chemical Engineering Journal. 183 : 46-52. microreactor. Ultrasonics Sonochemistry. concentration. Industrial & Engineering 19: 1252-1259. Chemistry Research. 51 : 232-239. Bernaudshaw N, Bruno A, Bianchi CL & Ashokkumar M. 2012. Graphene oxide Jimmy B, Kolev SD, Kentish SE & Son Y, Lim M, Khim J, Kim L-H & based Pt-TiO2 photocatalyst: ultrasound Ashokkumar M. 2012. A novel approach Ashokkumar M. 2012. Comparison of assisted synthesis, characterization for enhancing metal ion separation calorimetric energy and cavitation energy and catalytic efficiency. Ultrasonics using acoustic nebulisation. Ultrasonics for the removal of bisphenol-A: The Sonochemistry. 19 : 9-15. Sonochemistry. 19 : 435-439. effects of frequency and liquid height. Chemical Engineering J. 183 : 39-45. Cavalieri F, Zhou M, Tortora M, Lucilla Manivel A, Sivakumar R, Anandan B & Ashokkumar M 2012. Methods S & Ashokkumar M. 2012. Son Y, Nam S, Ashokkumar M & of preparation of multifunctional Ultrasound-assisted synthesis of hybrid Khim J. 2012. Comparison of energy microbubbles and their in vitro / in phosphomolybdate-polybenzidine consumptions between ultrasonic, vivo assessment of stability, functional containing silver nanoparticles for mechanical, and combined soil washing and structural properties. Current electrocatalytic detection of chlorate, processes. Ultrasonics Sonochemistry. Pharmaceutical Design. 18 : 2135-2151. bromate and iodate ions in aqueous 19 : 395-398. solutions. Electrocatalysis. 3 : 22-29. Chandrapala J, Martin GJO, Zisu , Kentish Vinodgopal K, Bernaudshaw N, Salleh SE & Ashokkumar M. 2012. The effect Melino S, Zhou M, Tortora M, Paci M, N, Lightcap IV, Grieser F, Ashokkumar of ultrasound on casein micelle integrity. Cavalieri F & Ashokkumar M. 2012. M, Ding TT & Kamat PV. 2012. Dual- Journal of Dairy Science. 95 : 6882-6890. Molecular properties of lysozyme- frequency ultrasound for designing two microbubbles: towards the protein and dimensional catalyst surface: Reduced nucleic acid delivery. Amino Acids. 43 : graphene oxide-Pt composite. Colloids 885-896. & Surfaces A: Physicochemical & Engineering Aspects. 409 : 81-87.

36 School of Chemistry Annual Report 2012 Zhou M, Cavalieri F & Ashokkumar M. Sader J, Hughes BD, Sanelli J & Bieske Chen D, Huang, Caruso RA & Cheng. 2012. Modification of the size distribution EJ. 2012. Effect of multiplicative noise 2012. Mesoporous titanium oxide spheres of lysozyme microbubbles using a post- on least-squares parameter estimation for high efficiency dye-sensitized solar sonication technique. Instrumentation with applications to the atomic force cells. In Miyasaka Prof (ed), Trends in Science & Technology. 40 : 51-60. microscope. Review of Scientific Advanced Sensitized & Organic Solar Instruments. 83 : 055106. Cells. Tokyo, Japan: CMC Publishing, pp. Zhou M, Cavalieri F, Caruso F & 92-105. Ashokkumar M. 2012. Confinement Chalyavi N, Troy, Bacskay, Nauta , Kable, of acoustic cavitation for the synthesis Reid & Schmidt. 2012. Excitation spectra Chen Z, Greaves TL, Caruso RA & of protein-shelled nanobubbles for of the jet-cooled 4-phenylbenzyl and 4-(4 Drummond. 2012. Long-range ordered diagnostics and nucleic acid delivery. ACS ‘-methylphenyl)benzyl radicals. Journal of lyotropic liquid crystals in intermediate- Macro Letters. 1 : 853-856. Physical Chemistry A. 116 : 10780-10785. range ordered protic ionic liquid used as templates for hierarchically porous silica. Zuo YY, Hebraud P, Hemar Y & Troy T, Nakajima M, Chalyavi N, Nauta J. Materials Chemistry. 22 : 10069-10076. Ashokkumar M. 2012. Quantification of K, Kable S & Schmidt T. 2012. Hydroxyl high-power ultrasound induced damage addition to aromatic alkenes: resonance- Chen Z, Greaves TL, Fong C, Caruso on potato starch granules using light stabilized radical intermediates. Journal of RA & Drummond. 2012. Lyotropic liquid microscopy. Ultrasonics Sonochemistry. 19 Physical Chemistry A. 116 : 7906-7915. crystalline phase behaviour in amphiphile- : 421-426. protic ionic liquid systems. Physical Alley K, Poneti G, Aitken J, Hocking R, Chemistry Chemical Physics. Chantler CT, Rae N, Islam M, Best SP, Moubaraki B, Murray K, Abrahams BF, 14 : 3825-3836. Yeo J, Smale L, Hester J, Mohammadi N Harris H, Sorace L & Boskovic C. 2012. & Wang F. 2012. Stereochemical analysis A two-step valence tautomeric transition Drisko G, Zelcer A, Wang XD, Caruso of ferrocene and the uncertainty of in a dinuclear cobalt complex. Inorganic RA & Soler-Illia GJ. 2012. Synthesis and fluorescence XAFS data. J. Synchrotron Chemistry. 51 : 3944-3946. photocatalytic activity of titania monoliths Radiation. 19 : 145-158. prepared with controlled macro- and Gotthardt J, White K, Abrahams BF, mesopore structure. ACS Applied Yeo J, Cheah MH, Bondin MI & Best SP. Ritchie C & Boskovic C. 2012. Fluorite Materials & Interfaces. 4 : 4123-4130. 2012. X-ray spectroscopy and structure topology in lanthanoid coordination elucidation of reactive electrogenerated polymers with di- and trimetallic building Drisko G, Zelcer, Caruso RA & Soler- tri-iron carbonyl sulfide clusters.Australian blocks. Crystal Growth & Design. 12 : Illia GJ. 2012. One-pot synthesis of silica Journal of Chemistry. 65 : 241-253. 4425-4430. monoliths with hierarchically porous structure. Microporous & Mesoporous Dryza V, Chalyavi N, Sanelli J & Bieske Ritchie C, Baslon, Moore EG, Reber Materials. 148 : 137-144. EJ. 2012. Electronic absorptions of the & Boskovic C. 2012. Sensitization of benzylium cation. Journal of Chemical lanthanoid luminescence by organic and Huang, Chen D, Li, Caruso RA & Cheng. Physics. 137 : 204304. inorganic ligands in lanthanoid-organic- 2012. Construction of nanostructured polyoxometalates. Inorganic Chemistry. 51 electrodes on flexible substrates using Dryza V, Poad & Bieske EJ. 2012. : 1142-1151. pre-treated building blocks. Applied Attaching molecular hydrogen to metal Physics Letters. 100 : 123102. cations: perspectives from gas-phase Chee Kimling M & Caruso RA. 2012. infrared spectroscopy. Physical Chemistry Sol-gel synthesis of hierarchically porous Huang F, Li Q, Thorogood GJ, Cheng

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40 School of Chemistry Annual Report 2012 Sraj L, Khairallah G, Da Silva GR & O’Hair Lindqvist LM, Vikstrom I, Chambers Macdougall PE, Aitken H, Scammells RA. 2012. Who wins: Pesci, Peters, JM, Mcarthur K, Anderson MA, Henley PJ, Kavanagh Y, Kyne SH & Schiesser or Deacon? Intrinsic reactivity orders KJ, Happo L, Cluse L, Johnstone RW, CH. 2012. 7-Selenabicyclo[2.2.1]heptane. for organocuprate formation via ligand Roberts AW, Kile BT, Croker BA, Burns Chemical Communications. 48 : 9126- decomposition. Organometallics. 31 : CJ, Rizzacasa MA, Strasser A & Huang 9128. 1801-1807. DCS. 2012. Translation inhibitors induce Neves Da Silva AC, Aitken H, Kyne cell death by multiple mechanisms Vikse KL, Khairallah G & O’Hair RA. S, Fensterbank L, Lacote E, Malacria and Mcl-1 reduction is only a minor 2012. Gas-phase unimolecular reactions M, Ollivier C & Schiesser CH. 2012. contributor. Cell Death & Disease. 3 : of pallada- and nickelalactone anions. Intramolecular homolytic substitution e409. 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Fluorescent angiotensin AT1 2-(4-methoxyphenyl)naphthalene: 2012. Synthesis and X-ray crystal receptor antagonists. Asian J. Organic An effective electrospray-active analogue structure of cynandione B analogues. Chemistry. 1 : 274-279. for 6-coordinating ligands. Australian Journal of Chemistry. 65 : 58- J. Organometallic Chemistry. Horvat SM & Schiesser CH. 2012. An 64. 716 : 252-257. ab initio and DFT study of homolytic Allen W & Separovic F. 2012. Membrane reactions by oxyacyl radicals at sulfur, Burns CJ, Fisk N, Heugel, Huang DC, protein structure and function. Biochimica selenium and tellurium. Tetrahedron. 68 : Segal D, White C, Wagler & Rizzacasa et Biophysica Acta-Biomembranes. 1818: 10482-10488. MA. 2012. Synthesis and biological 125. evaluation of a potent salicylihalamide A Jani N, Ziogas J, Angus JA, Schiesser Balakrishnan Nair V, Samuel C, lactam analogue. Organic & Biomolecular CH, Macdougall PE, Grange R & Wright Separovic F, Hossain M & Wade Chemistry. 10 : 8147-8153. CE. 2012. Dual action molecules: JD. 2012. Human relaxin-2: historical bioassays of combined novel antioxidants Birkett S, Loits D, Wimala S & Rizzacasa perspectives and role in cancer biology. and angiotensin II receptor antagonists. MA. 2012. Synthesis of myxobacteria Amino Acids. 43 : 1131-1140. European J. Pharmacology. 695 : 96-103. metabolites. Pure & Applied Chemistry. Bowie H, Separovic F & Tyler J. 2012. 84 : 1421-1433. Kyne S, Aitken H, Horvat SM, Lin CY, Host-defense peptides of Australian Coote ML & Schiesser CH. 2012. Boonsri, Gunawan C, Krenske EH anurans. Part 2. Structure, mechanism Homolytic Substitution Chemistry: & Rizzacasa MA. 2012. Synthetic of action, and evolutionary significance. From James Franz to Antihypertensives. studies towards the mulberry Diels– Peptides. 37 : 174-188. 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www.chemistry.unimelb.edu.au 41 Fraser S, Mulet, Martin, Praporski, Heskes A, Lincoln CN, Goodger JQ, Khan I & White JM. 2012. Simple and Mechler, Hartley G, Polyzos & Separovic Woodrow IE & Smith TA. 2012. efficient one-pot synthesis, spectroscopic F. 2012. Surface immobilization of bio- Multiphoton fluorescence lifetime characterization and crystal structure of functionalized cubosomes: sensing of imaging shows spatial segregation of methyl 5-(4-chlorobenzoyloxy)-1-phenyl- proteins by quartz crystal microbalance. secondary metabolites in Eucalyptus 1h-pyrazole-3-carboxylate. Crystals. 2 : Langmuir. 28 : 620-627. secretory cavities. J. Microscopy - Oxford. 967-973. 247 : 33-42. Lu, Burrell G, Separovic F & Zhao. 2012. Laurens E, Yeoh S, Rigopoulos A, Cao Electrochemistry of room temperature Smith TA, Hirvonen LM, Lincoln CN D, Cartwright GA, O’Keefe GJ, Tochon- protic ionic liquids: a critical assessment & Hao X. 2012. Deep-UV confocal Danguy H, White JM, Scott A & for use as electrolytes in electrochemical fluorescence imaging and super- Ackermann U. 2012. Radiolabelling and applications. Journal of Physical Chemistry resolution optical microscopy of biological evaluation of novel haloethylsulfoxides as B. 116 : 9160-9170. samples. J. Innovative Optical Health PET imaging agents for tumor hypoxia. Sciences. 5 : 1250025. Nuclear Medicine & Biology. 39 : 871-882. Sani M, Whitwell T & Separovic F. 2012. Lipid composition regulates Van den Heuvel W & Soncini A. 2012. Lobachevsky P, Smith J, Denoyer D, the conformation and insertion of NMR chemical shift in an electronic Skene CE, White JM, Flynn BL, Kerr the antimicrobial peptide maculatin state with arbitrary degeneracy. Physical DJ, Hicks RJ & Martin RF. 2012. Tumour 1.1. Biochimica et Biophysica Acta- Review Letters. 109 : 073001. targeting of Auger emitters using Biomembranes. 1818 : 205-211. DNA ligands conjugated to octreotate. Bernardini G, Wedd AG, Zhao C & Bond International J. Radiation Biology. 88 : Sani M, Separovic F & Gehman JD. AM. 2012. Electrochemical probing of 1009-1018. 2012. The lipid network. Biophysical the photoreduction of molybdenum and Reviews. 4 : 283-290. tungsten Dawson-type polyoxometalates Nguyen NH, Sleebs BE, White JM & in molecular and ionic liquid media Hughes AB. 2012. Diastereoselective Shabanpoor F, Hossain M, Ryan PJ, Belgi using water as an electron donor. Dalton synthesis of highly functionalized A, Layfield SL, Kocan, Zhang, Samuel Transactions. 41 : 9944-9954. beta2,2,3-substituted amino acids from C, Gundlach AL, Bathgate R, Separovic 4-substituted-1,3-oxazinan-6-ones. F & Wade JD. 2012. Minimization of Bernardini G, Wedd AG, Zhao C & Bond Tetrahedron. 68 : 4745-4756. human Relaxin-3 leading to high-affinity AM. 2012. Photochemical oxidation of analogues with increased selectivity water and reduction of polyoxometalate Tilley A, Chen M, Danczak SM, Ghiggino for Relaxin-Family Peptide 3 Receptor anions at interfaces of water with ionic KP & White JM. 2012. Electronic energy (RXFP3) over RXFP1. Journal of Medicinal liquids or diethylether. Proc. National transfer in pendant MEH-PPV polymers. Chemistry. 55 : 1671-1681. Academy of Sciences USA. 109 : 11552- Polymer Chemistry. 3 : 892-899. 11557. Weber D, Gehman JD, Separovic F Yeoh SD, Harris B, Simons TJ & White & Sani M. 2012. Copper modulation Zimmermann M, Udagedara S, Sze C, JM. 2012. Structure correlation study of amyloid beta 42 interactions with Ryan TM, Howlett GJ, Xiao Z & Wedd of the beckmann rearrangement: X-ray model membranes. Australian Journal of AG. 2012. PcoE - A metal sponge structural analysis and 13C-13C 1-bond Chemistry. 65 : 472-479. expressed to the periplasm of copper coupling constant study of a range resistance Escherichia coli. Implication of of cyclohexanone oxime derivatives. Dufourc E, Buchoux Toupe, Sani its function role in copper resistance. J. Australian Journal of Chemistry. 65 : 905- M, Jean-Francois, Kemthemourian, Inorganic Biochemistry. 115 : 186-197. 917. Grelard, Loudet-Courreges C, Laguerre C, Elezgaray, Desbat B & Odaert. 2012. Churches QI, Mulder RJ, White JM, Goeschen C, White JM, Gable RW Membrane interacting peptides: From Tsanaktsidis J & Duggan PJ. 2012. & Wille U. 2012. Oxidative damage killers to helpers. Current Protein & Peptide The synthesis of a cubane-substituted of pyrimidine nucleosides by the Science. 7 : 620-631. dipeptide. Australian Journal of Chemistry. environmental free radical oxidant NO3 65 : 690-693. in the absence and presence of NO2 and JD & Sani M. 2012. Antimicrobial other radical and non-radical oxidants. peptides: agents of public health. Hughes AB, Verdon CM & White JM. Australian Journal of Chemistry. 65 : 427- Australian Biochemist. 43 : 13-16. 2012. Diastereoselectivity in unusual 437. intermolecular tandem Michael reactions. Dao LV, Hall C, Vu HL, Dinh KB, Balaur E, Tetrahedron. 68 : 1979-1987. Wille U. 2012. Radical photochemistry. Hannaford P & Smith TA. 2012. Phase- CRC Handbook of Organic Photochemistry matched generation of highly coherent Kerr DJ, Miletic M, Chaplin JH, White & Photobiology. Boca Raton FL, United radiation in the water window region. JM & Flynn BL. 2012. Oxazolidinone- States: CRC Press (Taylor & Francis Applied Optics. 51 : 4240-4245. promoted, torquoselective Nazarov Group) cyclizations. Organic Letters. 14 : 1732- Dao LV, Vu HL, Dinh KB, Gaffney N, 1735. Gilbert RE, Zhang Y, Williams SJ, Balaur E, Hannaford P & Smith TA. Zammit S, Stapleton DI, Cox AJ, Krum 2012. Generation of Coherent Radiation Khan I, Ibrar A & White JM. 2012. Ethyl H, Langham RG & Kelly DJ. 2012. A in the Water Window. Research in Optical 2,6-dimethoxybenzoate: synthesis, purpose-synthesised anti-fibrotic agent Sciences, OSA Technical Digest. United spectroscopic and X-ray crystallographic attenuates experimental kidney diseases States: Optical Society of America. analysis. Crystals. 2 : 521-527. in the rat. PLoS One. 7 : e47160.

42 School of Chemistry Annual Report 2012 Heskes A, Goodger JQ, Tsegay S, Quach Zhang Y, Edgley AJ, Cox AJ, Powell, Barril, Clark & Scollary GR. 2012. T, Williams SJ & Woodrow IE. 2012. Wang, Kompa A, Stapleton DI, Zammit Chemistry of ascorbic acid and sulfur Localization of oleuropeyl glucose esters S, Williams SJ, Kelly DJ, Gilbert RE & dioxide as an antioxidant system relevant and a flavanone to secretory cavities of Krum H. 2012. FT011, a new anti-fibrotic to white wine. Analytica Chimica Acta. myrtaceae. PLoS One. 7 : 1-9. drug, attenuates fibrosis and chronic 732 : 186-193. heart failure in experimental diabetic Kim Y, Seok M, Woodman L, Williams Scollary GR, Pasti G, Kallay M, Blackman cardiomyopathy. European J. Heart SJ & Kim K. 2012. 3’,4’-Dihydroxyflavonol J & Clark A. 2012. Astringency response Failure. 14 : 549-562 reduces vascular contraction through of red wines: potential role of molecular Ca2+ desensitization in permeabilized Harcourt RD & Klapotke M. 2012. assembly. Trends in Food Science & rat mesenteric artery. Naunyn- Valence bond structures for the N3- anion, Technology. 27 : 25-36. Schmiedeberg’s Archives of Pharmacology. the N radical and the N - radical anion. 3 6 Hossain MA, Wade JD & Bathgate RA. 385 : 191-202. Zeitschrift fur naturforschung Section B - A 2012. Chimeric relaxin peptides highlight J. Chemical Sciences. 67b : 935-943. Quach T, Tsegay SG, Thompson J, the role of the A-chain in the function of Kukushkin V, Alonzi S, Butters D, Davies Karas JA, Boland M, Haigh CL, H2 relaxin. Peptides. 35 : 102-106. J & Williams SJ. 2012. Fleetamine Johanssen VA, Hill A, Barnham K, Zhang W-J, Luo X, Liu Y-L, Shao X-X, (3-O-alpha-D-glucopyranosyl- Collins S & Scanlon D. 2012. Microwave Wade JD, Bathgate RAD & Guo Z-Y. swainsonine): Synthesis of a hypothetical synthesis of prion protein fragments up 2012. Site-specific DOTA/europium- inhibitor of endo-alpha-mannosidase. to 111 amino acids in length generates labeling of recombinant human relaxin-3 Tetrahedron-Asymmetry. 23 : 992-997. biologically active peptides. International for receptor-ligand interaction studies. J. Peptide Research & Therapeutics. 18 : Thompson J, Dabin, Iglesias-Fernandez, Amino Acids. 43 : 983-992. 21-29. Ardevol, Dinev Z, Williams SJ, Bande, Ng WLV, Taylor MK & Young CG. Siriwardena, Moreland, Hu, Smith K, Shabanpoor F, Bathgate RA, Belgi A, 2012. Reactivity studies of Oxo−Mo(IV) Gilbert J, Rovira & Davies J. 2012. The Chan J, Balakrishnan Nair V, Wade JD complexes containing potential hydrogen- reaction coordinate of a bacterial GH47 & Hossain MA. 2012. Site-specific bond acceptor/donor phenolate ligands. alpha-mannosidase: a combined quantum conjugation of a lanthanide chelator and Inorganic Chemistry. 51 : 3202-3211. mechanical and structural approach. its effects on the chemical synthesis Angewandte Chemie - International and receptor binding affinity of human Edition. 51 : 10997-11001. relaxin-2 hormone. Biochemical & Biophysical Research Communications. Thompson J, Williams R, Hakki Z, Alonzi 420 : 253-256. S, Wennekes , Gloster M, Songsrirote , Thomas-Oates E, Wrodnigg M, Spreitz , Faber PA, Kessler AJ, Bull JK, McKelvie Stutz E, Butters D, Williams SJ & Davies ID, Meysman FJR & Cook PLM. 2012. J. 2012. Structural and mechanistic insight The role of alkalinity generation in into N-glycan processing by endo-- controlling the fluxes of CO2 during mannosidase. Proc. National Academy of emersion and inundation on tidal flats. Sciences USA. 109 : 781-786. Biogeosciences. 9 : 4087-4097. Tilley AJ, Zanatta SD, Qin CX, Kim IK, Pencharee S, Faber PA, Ellis PS, Cook P, Seok YM, Stewart A, Woodman OL & Intaraprasert J, Grudpan K & McKelvie Williams SJ. 2012. 2-Morpholinoisoflav- ID. 2012. Underway determination of 3-enes as flexible intermediates in the dissolved inorganic carbon in estuarine synthesis of phenoxodiol, isophenoxodiol, waters by gas-diffusion flow analysis with equol and analogues: Vasorelaxant (CD)-D-4 detection. Analytical Methods: properties, estrogen receptor binding advancing methods & applications. 4 : and Rho/RhoA kinase pathway inhibition. 278-1283. Bioorganic & Medicinal Chemistry. 20 : Tappin AD, Mankasingh U, McKelvie ID 2353-2361. & Worsfold PJ. 2012. Temporal variability Tsegay SG, Williams R & Williams SJ. in nutrient concentrations and loads 2012. Synthesis of glycosyl fluorides in the River Tamar and its catchment, from thio-, seleno-, and telluroglycosides (SW England) between 1974 and 2004. and glycosyl sulfoxides using Environmental Monitoring & Assessment. aminodifluorosulfinium tetrafluoroborates. 185 : 4791-818. Carbohydrate Research. 357 : 16-22. Bouzanquet, Barril C, Clark C, Dias DA & Van der Peet P, Ralton JE, Mcconville Scollary GR. 2012. A novel glutathione- MJ & Williams SJ. 2012. Discovery hydroxycinnamic acid product generated of inhibitors of Leishmania beta- in oxidative wine conditions. J. Agricultural 1,2-mannosyltransferases using a & Food Chemistry. 60 : 12186-12195. click-chemistry-derived guanosine monophosphate library. PLoS One. 7 : e32642.

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