Table S2: Differentially Expressed Genes in Monocytes from SJIA

BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Ann Rheum Dis

Table S2: Differentially expressed genes in monocytes from SJIA patients with high ferritin vs normal ferritin ENTREZID logFC AveExpr t P.Value adj.P.Val MS4A4A 51338 2.190196 4.244735 8.4317 3.03E-10 3.93E-06 FCGR1A 2209 1.832626 5.191407 7.732826 2.31E-09 1.39E-05 WASF1 8936 2.152067 1.43915 7.530783 3.69E-09 1.39E-05 FAM20A 54757 2.474761 3.578268 7.632571 4.28E-09 1.39E-05 CLU 1191 4.534403 3.843633 7.551856 1.07E-08 2.77E-05 SMAD1 4086 1.268278 3.507093 6.633495 6.40E-08 0.000138 FZD5 7855 1.246973 2.879759 6.517221 9.29E-08 0.000145 PIM1 5292 1.271881 3.884803 6.508848 9.54E-08 0.000145 FPR2 2358 1.360192 5.004079 6.499801 1.01E-07 0.000145 ARID5B 84159 1.890049 3.750909 6.490162 1.20E-07 0.000156 SOCS3 9021 2.310428 2.737279 6.495284 1.35E-07 0.000159 FCGR1B 2210 1.694497 5.154892 6.217976 3.03E-07 0.000328 DACH1 1602 1.539506 1.506071 6.065837 3.97E-07 0.000396 CACNA2D3 55799 -1.92407 4.213692 -6.06965 4.68E-07 0.000434 FPR1 2357 1.209795 7.192649 5.940801 6.01E-07 0.000517 SH3PXD2A 9644 -1.03401 4.074356 -5.91559 6.44E-07 0.000517 SQOR 58472 0.73375 5.969033 5.896744 6.84E-07 0.000517 MCTP2 55784 1.896449 5.61473 5.983647 7.18E-07 0.000517 DYSF 8291 1.544211 6.388747 5.865596 8.90E-07 0.000607 DSC2 1824 1.764703 5.047865 5.83971 1.08E-06 0.000703 STON2 85439 -1.29121 3.458252 -5.70943 1.25E-06 0.000733 GCNT1 2650 0.852763 4.966676 5.691336 1.33E-06 0.000733 CFL1 1072 0.851705 5.97814 5.678738 1.38E-06 0.000733 GNG10 2790 1.107621 4.812675 5.663033 1.45E-06 0.000733 ZNF175 7728 -0.93175 4.073791 -5.65353 1.50E-06 0.000733 UBE3D 90025 -1.03666 2.62462 -5.64905 1.52E-06 0.000733 SMC2 10592 -0.98014 3.854468 -5.64761 1.53E-06 0.000733 CD81 975 1.02684 2.9974 5.634939 1.59E-06 0.000735 LIMK2 3985 1.081223 5.000122 5.624567 1.64E-06 0.000735 CPT1A 1374 0.907861 5.610705 5.589689 1.84E-06 0.000791 GM2A 2760 0.864216 6.76521 5.565654 1.99E-06 0.000791 GPR84 53831 1.528135 2.378117 5.568409 1.99E-06 0.000791 POMP 51371 0.836364 4.855967 5.561759 2.01E-06 0.000791 ORMDL2 29095 0.938696 4.604043 5.549501 2.09E-06 0.000798 F5 2153 0.878972 6.963642 5.519477 2.30E-06 0.000854 ACAD11 84129 -0.7953 3.702708 -5.5014 2.44E-06 0.00088 PLAC8 51316 1.679132 5.792997 5.562184 2.58E-06 0.000905 CD82 3732 0.961846 3.508497 5.433299 3.04E-06 0.001011 CD1E 913 -2.20953 1.335264 -5.43976 3.04E-06 0.001011 SLC39A8 64116 1.712669 3.175458 5.456354 3.21E-06 0.001021 TMEM167A 153339 0.749058 6.89511 5.414435 3.23E-06 0.001021 PAN2 9924 -0.58892 5.233771 -5.39184 3.47E-06 0.001072 LITAF 9516 1.222942 6.265017 5.377836 3.85E-06 0.001161 BLOC1S1 2647 1.101181 3.08831 5.352263 3.94E-06 0.001161 F2RL2 2151 -1.08761 3.63738 -5.34442 4.04E-06 0.001164

Schulert GS, et al. Ann Rheum Dis 2020;0:1–9. doi: 10.1136/annrheumdis-2020-217470 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Ann Rheum Dis

FAM129A 116496 0.933794 6.750819 5.336332 4.15E-06 0.001169 TMED8 283578 0.563176 5.937928 5.302766 4.62E-06 0.001274 DNAJC15 29103 1.051614 5.643874 5.273667 5.08E-06 0.001373 TPST2 8459 0.881668 5.294534 5.258252 5.32E-06 0.001409 RHOU 58480 0.871794 5.003252 5.229954 5.83E-06 0.001511 CR1 1378 1.115447 7.179779 5.17101 7.23E-06 0.001733 VAMP5 10791 1.215261 3.075069 5.164022 7.34E-06 0.001733 MT2A 4502 1.533108 2.926509 5.190953 7.47E-06 0.001733 TIFA 92610 1.049307 4.001225 5.152155 7.47E-06 0.001733 R3HDM4 91300 1.002544 3.518205 5.146712 7.60E-06 0.001733 KREMEN1 83999 0.886133 4.166079 5.146043 7.61E-06 0.001733 NEMP1 23306 -1.03939 3.564945 -5.14598 7.62E-06 0.001733 AQP9 366 1.735848 5.858342 5.215323 7.99E-06 0.001787 STOM 2040 0.882168 5.872767 5.116898 8.36E-06 0.001837 UBAP1 51271 0.634887 5.184932 5.11152 8.50E-06 0.001837 B4GALT5 9334 0.921163 6.428555 5.093532 9.00E-06 0.001914 CTSA 5476 0.919311 7.341106 5.080355 9.39E-06 0.001963 PTPDC1 138639 -1.36549 1.640829 -5.06876 9.74E-06 0.001968 PRPS2 5634 0.724368 3.55328 5.067444 9.78E-06 0.001968 CCDC14 64770 -0.86784 4.937713 -5.06474 9.86E-06 0.001968 PRRG4 79056 0.553566 5.060522 5.052141 1.03E-05 0.001974 TNNT1 7138 1.722227 1.722191 5.069485 1.03E-05 0.001974 GYG1 2992 0.556925 5.371168 5.049305 1.04E-05 0.001974 GMFG 9535 0.699049 6.36054 5.042922 1.06E-05 0.001974 IFITM2 10581 1.869608 6.767794 5.135646 1.07E-05 0.001974 RBFA 79863 -0.86711 2.585778 -5.03525 1.08E-05 0.001979 TMEM127 55654 0.7228 7.12166 5.026114 1.12E-05 0.002008 CD63 967 1.161541 6.641661 5.039156 1.13E-05 0.002008 JAK3 3718 1.071233 5.456367 5.016692 1.18E-05 0.00204 BASP1 10409 1.277944 5.406056 5.036456 1.18E-05 0.00204 TMBIM6 7009 0.629772 8.182448 5.002579 1.20E-05 0.00205 LILRA6 79168 0.868465 6.919574 4.995195 1.23E-05 0.00205 IMPA2 3613 0.684781 4.92483 4.994465 1.23E-05 0.00205 RAB8B 51762 0.788068 6.208799 4.986434 1.26E-05 0.002056 KAT2A 2648 -1.03304 2.878202 -4.98338 1.28E-05 0.002056 UBA5 79876 -0.7562 4.054101 -4.98172 1.28E-05 0.002056 IGF2BP3 10643 1.43472 3.059351 4.980855 1.35E-05 0.002134 H2AFJ 55766 1.094605 3.355427 4.96234 1.37E-05 0.002134 CHCHD7 79145 0.8274 5.086581 4.954776 1.40E-05 0.002148 TARBP1 6894 -0.85294 4.873378 -4.95227 1.41E-05 0.002148 ST14 6768 1.270406 3.340502 4.963409 1.42E-05 0.002148 SMPDL3A 10924 0.853486 3.37267 4.940909 1.46E-05 0.00216 ZMYND11 10771 -0.75582 4.031209 -4.93998 1.47E-05 0.00216 VWA5A 4013 1.051467 3.34311 4.936394 1.48E-05 0.00216 MT1X 4501 1.31619 2.052842 4.928442 1.52E-05 0.002178 CXCL16 58191 0.955675 5.388337 4.926836 1.53E-05 0.002178 UBE2L3 7332 0.57562 5.130905 4.920006 1.56E-05 0.002193

CTNND1 1500 -0.66665 6.877517 -4.91775 1.57E-05 0.002193 MGST3 4259 0.691213 5.770989 4.912856 1.60E-05 0.002204 UBE2J1 51465 0.934295 6.235453 4.896049 1.68E-05 0.002299 ZNF589 51385 -0.68874 4.629289 -4.89282 1.70E-05 0.002299 KANK2 25959 -0.56629 3.95006 -4.87811 1.78E-05 0.002358 RSAD1 55316 -0.81287 3.809714 -4.87599 1.79E-05 0.002358 NDUFB9 4715 0.715062 5.477529 4.875034 1.80E-05 0.002358 PPP1R3B 79660 0.869002 4.489008 4.865309 1.86E-05 0.002407 ZNF736 728927 -0.65624 4.983984 -4.86055 1.88E-05 0.00242 CDK5RAP2 55755 -0.85141 4.863029 -4.84835 1.96E-05 0.00249 BCL2A1 597 1.309598 4.123117 4.860376 2.07E-05 0.002597 CLEC2D 29121 -0.9064 5.64618 -4.82892 2.08E-05 0.002597 TAF4B 6875 -1.47777 1.439848 -4.8206 2.14E-05 0.002637 ALDH1A1 216 -1.58705 6.384964 -4.88851 2.15E-05 0.002637 FCGR3A 2214 1.411295 6.324651 4.859069 2.20E-05 0.002655 FLVCR2 55640 0.943766 4.743243 4.807768 2.23E-05 0.002655 ACSL1 2180 1.063163 7.070704 4.815908 2.24E-05 0.002655 MTR 4548 -0.48 5.943447 -4.80402 2.25E-05 0.002655 LOC10099671.01E+08 -1.25676 3.534469 -4.79898 2.29E-05 0.002674 ACAA2 10449 0.657251 6.012664 4.771006 2.50E-05 0.002894 S100A9 6280 1.277946 8.08226 4.788976 2.59E-05 0.002947 DERL1 79139 0.512209 5.818377 4.759603 2.59E-05 0.002947 C1ORF228 339541 0.762018 2.441595 4.753988 2.64E-05 0.002973 ELMO2 63916 0.667265 5.695467 4.738732 2.77E-05 0.003093 RAB1B 81876 0.844596 4.422059 4.708019 3.05E-05 0.003377 ZNHIT1 10467 0.652154 5.383766 4.70184 3.11E-05 0.003414 TNFSF8 944 -0.86705 5.534343 -4.69881 3.14E-05 0.003417 UBE2F 140739 0.46135 4.551357 4.694985 3.17E-05 0.00343 RAB13 5872 0.774534 4.311582 4.671621 3.41E-05 0.00366 C6ORF89 221477 0.462461 5.447402 4.657177 3.57E-05 0.003755 CAPZB 832 0.589863 5.647883 4.656595 3.58E-05 0.003755 AFF3 3899 -0.84919 4.125988 -4.65563 3.59E-05 0.003755 CLIC1 1192 0.768367 7.130546 4.653058 3.62E-05 0.003755 SLC2A3 6515 1.007611 6.68736 4.648538 3.76E-05 0.003872 MCEMP1 199675 1.404853 5.951082 4.681543 3.85E-05 0.003936 S100A8 6279 1.380916 9.570264 4.657299 4.08E-05 0.004132 GNG5 2787 0.838863 5.254902 4.610478 4.13E-05 0.004157 PDE4DIP 9659 -0.7558 6.583324 -4.60504 4.21E-05 0.004171 IGFBP7 3490 0.848944 4.135958 4.604442 4.21E-05 0.004171 WBP2 23558 0.68723 5.050039 4.600678 4.26E-05 0.004188 IFITM1 8519 2.462037 2.411347 4.701092 4.30E-05 0.004196 DBI 1622 0.861863 4.731628 4.594297 4.35E-05 0.004209 GPR135 64582 -1.03125 1.978208 -4.59076 4.40E-05 0.004224 NCAPG2 54892 -0.91638 2.615493 -4.58737 4.44E-05 0.004238 EMB 133418 0.655008 7.049032 4.578224 4.57E-05 0.004301 ZNF223 7766 -0.83406 2.200936 -4.57795 4.58E-05 0.004301 PCDH12 51294 -1.10161 2.708648 -4.55547 4.91E-05 0.00458

CNN2 1265 0.768586 6.313244 4.552773 4.95E-05 0.004586 LDHA 3939 0.689304 8.141726 4.547979 5.02E-05 0.004622 LY96 23643 0.905547 2.86261 4.540239 5.15E-05 0.004701 CDCP1 64866 0.941764 3.199566 4.534276 5.24E-05 0.004756 PPFIBP2 8495 -0.69 4.962403 -4.52836 5.34E-05 0.00477 SASH1 23328 -1.02676 5.103488 -4.53435 5.34E-05 0.00477 LMNB1 4001 0.924074 4.69961 4.527305 5.37E-05 0.00477 NSUN5P1 155400 -0.58563 5.153174 -4.52378 5.42E-05 0.00478 MAN1A1 4121 0.805646 4.907672 4.511046 5.64E-05 0.0049 FAM89A 375061 1.398126 2.078895 4.5153 5.64E-05 0.0049 NOP10 55505 0.978386 4.015353 4.512363 5.67E-05 0.0049 ANPEP 290 1.501716 7.145505 4.559536 5.80E-05 0.004944 PGD 5226 0.641955 7.121646 4.501058 5.81E-05 0.004944 RTN1 6252 -1.24411 4.826474 -4.52454 5.83E-05 0.004944 PRKAR1A 5573 0.543656 7.60276 4.493301 5.96E-05 0.005016 AMZ1 155185 -1.51373 2.177115 -4.48464 6.12E-05 0.005077 CLIC4 25932 0.65167 4.764311 4.483245 6.15E-05 0.005077 IRF2BPL 64207 1.044006 2.079706 4.482514 6.16E-05 0.005077 LRRC8E 80131 -0.77514 1.465499 -4.48112 6.19E-05 0.005077 CTSB 1508 0.595585 7.825419 4.46964 6.41E-05 0.005228 MYCBP 26292 0.621976 5.0964 4.466584 6.47E-05 0.005245 OSGEPL1 64172 -0.78721 2.202365 -4.46369 6.53E-05 0.00526 DIP2A 23181 -0.48326 5.797962 -4.45976 6.61E-05 0.005291 ATP6V0E1 8992 0.611572 6.755493 4.444523 6.93E-05 0.005513 ACTB 60 0.709205 11.28401 4.419387 7.49E-05 0.005893 BCL10 8915 0.452083 4.599616 4.41904 7.50E-05 0.005893 APCDD1 147495 1.534557 2.319545 4.434921 7.55E-05 0.005899 IL10RB 3588 0.54203 5.652421 4.414375 7.61E-05 0.005907 LAIR1 3903 0.623758 6.251994 4.408737 7.74E-05 0.005975 RAP2C 57826 0.554893 6.266871 4.392185 8.15E-05 0.006251 PLIN2 123 0.693008 5.504834 4.390286 8.19E-05 0.006251 ETFB 2109 0.586 6.635716 4.383322 8.37E-05 0.00635 SEZ6L 23544 -2.15748 1.76243 -4.39801 8.50E-05 0.006411 MRPS25 64432 -0.68264 5.122273 -4.37443 8.60E-05 0.006451 CALM3 808 0.736128 5.288455 4.371759 8.68E-05 0.006467 ATOX1 475 0.796646 5.329753 4.359478 9.01E-05 0.006678 FXN 2395 -0.46349 5.27254 -4.35652 9.09E-05 0.006701 AMY2B 280 -0.70333 4.886215 -4.34251 9.49E-05 0.006957 LOC93622 93622 -0.64116 3.289467 -4.34035 9.56E-05 0.006964 MTAP 4507 -0.66487 5.50173 -4.3378 9.63E-05 0.006979 AK4 205 0.860795 3.51075 4.329055 9.90E-05 0.00713 LGALS1 3956 1.170861 4.647182 4.346297 0.000101 0.007247 MMP19 4327 1.194514 2.251717 4.318331 0.000102 0.007288 VNN2 8875 1.021109 6.807815 4.328941 0.000103 0.007308 TP53INP2 58476 0.903018 3.122584 4.312223 0.000104 0.007333 HP 3240 2.055166 4.002413 4.39219 0.000105 0.007333 EMC3 55831 0.440069 4.95191 4.308242 0.000105 0.007356

ENY2 56943 0.576608 6.447389 4.306213 0.000106 0.007362 CEACAM19 56971 -0.77038 3.535356 -4.3043 0.000107 0.007366 LAMTOR3 8649 0.535472 5.162358 4.300044 0.000108 0.007389 CYSTM1 84418 1.016286 3.678907 4.303651 0.000108 0.007389 FCER1G 2207 0.813497 8.732538 4.297782 0.000109 0.007397 TPM4 7171 0.582915 7.572452 4.291467 0.000111 0.007502 SLC9A1 6548 0.688898 4.639892 4.277838 0.000116 0.007687 RNF185 91445 0.436846 4.499787 4.277677 0.000116 0.007687 FURIN 5045 0.964099 4.685679 4.282524 0.000116 0.007687 C2 717 0.886284 3.966178 4.275843 0.000117 0.007687 RBX1 9978 0.686693 5.102508 4.273489 0.000117 0.007687 UQCRB 7381 0.66716 6.706467 4.269544 0.000119 0.007687 SWAP70 23075 0.706471 5.551281 4.268586 0.000119 0.007687 GPR27 2850 1.119579 2.629459 4.27301 0.000119 0.007687 NAT9 26151 -0.82137 3.391501 -4.26749 0.00012 0.007687 KLHL2 11275 0.764851 5.420627 4.266993 0.00012 0.007687 CYSLTR2 57105 -1.07227 4.428773 -4.257 0.000126 0.007978 PELO 53918 0.739933 2.808515 4.249195 0.000126 0.007978 FLOT1 10211 0.827964 5.509204 4.24857 0.000127 0.007978 MXD1 4084 0.971072 7.96654 4.258345 0.000127 0.007978 CDS2 8760 0.426464 6.41446 4.243831 0.000129 0.00802 CHSY1 22856 0.593434 5.290658 4.24243 0.000129 0.00802 LILRB4 11006 0.842302 5.686507 4.242558 0.000129 0.00802 CYB5R3 1727 0.738843 5.539234 4.234483 0.000132 0.008156 ZNF780B 163131 -0.69691 5.240555 -4.23338 0.000133 0.008156 MYL6 4637 0.690059 7.664511 4.23105 0.000134 0.008175 NRBF2 29982 0.564073 4.980042 4.228615 0.000135 0.008198 SYS1 90196 0.561238 4.734508 4.225274 0.000136 0.008243 NEK1 4750 -0.52603 4.056532 -4.22357 0.000137 0.008248 TNIP1 10318 0.674472 5.73227 4.219199 0.000139 0.00832 CSF2RB 1439 0.678674 6.307454 4.216765 0.00014 0.008328 SGTB 54557 0.447512 5.676108 4.215865 0.00014 0.008328 GK 2710 1.036355 5.302758 4.229031 0.000141 0.008347 RNASE2 6036 1.708748 5.988171 4.277622 0.000143 0.00839 SRGAP3 9901 -0.4801 4.33233 -4.20754 0.000144 0.00839 NKG7 4818 2.081052 1.800923 4.261844 0.000144 0.00839 PHOSPHO1 162466 -0.96406 2.002634 -4.20521 0.000145 0.0084 CD1C 911 -1.19066 3.249478 -4.20886 0.000145 0.0084 IL1RN 3557 0.909205 5.339699 4.206541 0.000146 0.00843 STXBP2 6813 0.609163 6.659742 4.196339 0.000149 0.008516 TIMP1 7076 0.971081 5.631727 4.205016 0.000149 0.008516 LINC00680 1.07E+08 -0.53815 4.485994 -4.19363 0.00015 0.008516 MPDU1 9526 0.600523 3.68685 4.192387 0.00015 0.008516 PPP1R2 5504 0.542693 5.194283 4.189678 0.000152 0.00855 HIST1H4I 8294 1.117756 1.361691 4.185994 0.000153 0.008609 COQ10A 93058 -0.72184 2.722832 -4.18269 0.000155 0.008658 ARPC5 10092 0.570481 8.3866 4.180942 0.000156 0.008667

USB1 79650 0.759055 6.049911 4.178786 0.000157 0.008676 ARL5A 26225 -0.5617 5.476361 -4.17779 0.000157 0.008676 AP5B1 91056 0.679435 3.565156 4.171761 0.00016 0.008703 APOBEC3C 27350 0.627475 5.705494 4.171708 0.00016 0.008703 PGAM1 5223 0.704287 6.92305 4.171446 0.00016 0.008703 FAAH 2166 -1.16513 2.285118 -4.17125 0.00016 0.008703 IL10 3586 0.919404 1.998184 4.161687 0.000165 0.008893 MSRB1 51734 0.795311 4.423837 4.161395 0.000165 0.008893 PNP 4860 0.822145 5.22015 4.158272 0.000167 0.008912 2-Mar 51257 0.525233 3.912301 4.157259 0.000167 0.008912 SPIN2A 54466 -1.23099 2.839425 -4.15661 0.000168 0.008912 DEXI 28955 -0.83614 4.448436 -4.1538 0.000169 0.008952 AGAP6 414189 -0.49153 4.306042 -4.14912 0.000172 0.009043 PRRG1 5638 -1.76304 1.493242 -4.14972 0.000174 0.009134 S100Z 170591 -0.80684 3.909511 -4.14062 0.000176 0.009134 MYD88 4615 0.640649 8.200804 4.140531 0.000176 0.009134 CYP4A11 1579 -2.10569 1.469709 -4.15749 0.000176 0.009134 ZBTB44 29068 0.453811 6.08228 4.135868 0.000179 0.009208 CEP290 80184 -0.91427 3.269094 -4.13367 0.00018 0.009208 FAR2P1 440905 -1.19062 3.141805 -4.13336 0.00018 0.009208 SYT11 23208 0.565137 4.601751 4.132641 0.00018 0.009208 FCGR1CP 1E+08 2.343448 2.101684 4.202016 0.000183 0.009322 TRAPPC5 126003 0.847522 6.113218 4.125644 0.000186 0.009419 ARF4 378 0.584866 5.204273 4.117507 0.000189 0.009528 SNED1 25992 -0.93359 2.989759 -4.11236 0.000192 0.00964 SHISA5 51246 0.846886 5.587377 4.11282 0.000193 0.009657 NPIPB13 613037 -0.95052 3.492805 -4.10864 0.000194 0.009657 STAU1 6780 0.436283 5.684979 4.107951 0.000194 0.009657 IL5RA 3568 -0.97144 1.522591 -4.10525 0.000196 0.009695 PLIN3 10226 0.634654 4.822967 4.104161 0.000197 0.009695 FAM229A 1E+08 -0.8406 2.33013 -4.09781 0.0002 0.009845 ABHD2 11057 0.657332 7.612296 4.095143 0.000202 0.009888 COX8A 1351 0.871667 3.768297 4.094567 0.000203 0.009907 UNC5CL 222643 -1.14391 0.958375 -4.09168 0.000204 0.009907 N6AMT1 29104 -0.74145 3.173713 -4.09076 0.000205 0.009907 PPM1M 132160 0.650439 5.556486 4.089414 0.000206 0.009911 NDUFA4 4697 0.889364 5.603094 4.093103 0.000207 0.009931 DYNLRB1 83658 0.609444 3.518398 4.085396 0.000208 0.009931 C5ORF42 65250 -0.79387 4.756374 -4.08506 0.000208 0.009931 TRIM69 140691 0.816522 6.056595 4.084047 0.000209 0.009946 BEND6 221336 -0.83252 2.474137 -4.08142 0.000211 0.009968 SLC24A4 123041 -0.59837 7.479883 -4.07875 0.000212 0.009982 SLC18A1 6570 -0.9953 1.741032 -4.07856 0.000212 0.009982 NUP214 8021 0.612455 7.116234 4.076115 0.000214 0.010019 GRINA 2907 0.717352 5.744521 4.073524 0.000216 0.010062 ZBTB40 9923 -0.49046 5.347815 -4.07136 0.000217 0.010092 COL4A4 1286 -1.42091 1.224402 -4.06835 0.000219 0.010123

SYNJ2BP 55333 -0.46741 5.181973 -4.06797 0.000219 0.010123 LINC00694 1.03E+08 1.125676 1.262529 4.06475 0.000221 0.010149 ELK3 2004 0.437367 6.229934 4.064416 0.000222 0.010149 POLR2L 5441 0.857012 3.24642 4.063611 0.000222 0.010149 ABCA1 19 0.863781 6.020056 4.053391 0.000232 0.010565 DHCR24 1718 1.597608 2.303015 4.070445 0.000234 0.010615 LILRA5 353514 0.725116 5.292538 4.040366 0.000238 0.010762 GOLPH3 64083 0.503188 5.651731 4.039507 0.000239 0.010762 RBM18 92400 0.503412 4.765577 4.035073 0.000242 0.010855 SLC36A1 206358 0.704533 5.730692 4.034341 0.000243 0.010855 YIPF1 54432 0.531979 3.803349 4.031382 0.000245 0.010915 PTGS1 5742 -0.58846 5.570953 -4.02988 0.000246 0.010927 FAM107B 83641 0.66656 5.855922 4.027086 0.000248 0.010982 PSMB3 5691 0.676578 4.578079 4.024194 0.00025 0.011005 FAM8A1 51439 0.671089 4.296061 4.02171 0.000252 0.011005 MTPN 136319 0.591905 7.894385 4.020704 0.000253 0.011005 MTX1 4580 0.74113 4.468925 4.02063 0.000253 0.011005 ATP6V1C1 528 0.539323 5.878586 4.019164 0.000254 0.011005 ACSM3 6296 -0.81855 3.970421 -4.01801 0.000255 0.011005 VENTX 27287 -0.68778 4.445215 -4.018 0.000255 0.011005 RNASEK 440400 0.682768 6.184796 4.017437 0.000255 0.011005 USP36 57602 -0.57226 5.312362 -4.01419 0.000258 0.011046 3-Sep 55964 -0.92185 2.663612 -4.01308 0.000259 0.011046 PTGER2 5732 0.756158 3.315283 4.01288 0.000259 0.011046 ABRACL 58527 0.83203 4.073957 4.011902 0.00026 0.011059 WDR1 9948 0.494779 5.993771 4.009493 0.000262 0.011086 PLBD2 196463 0.578453 5.668144 4.007182 0.000263 0.011127 TNC 3371 -1.16575 2.790908 -4.00302 0.000267 0.011231 ZDHHC12 84885 0.970244 3.188308 3.998777 0.00027 0.011338 GCA 25801 0.78111 6.488514 3.995472 0.000273 0.011414 OSTF1 26578 0.504143 5.391744 3.992212 0.000276 0.011419 PPARG 5468 1.218369 2.354966 3.994867 0.000276 0.011419 ARHGEF9 23229 -0.48571 5.578342 -3.98984 0.000277 0.011419 TERF2IP 54386 0.442473 5.765617 3.989729 0.000278 0.011419 PTP4A2 8073 0.485349 8.675683 3.989007 0.000278 0.011419 CXCR1 3577 2.358655 2.365468 4.059325 0.000278 0.011419 HIST2H2BF 440689 1.285377 3.227485 4.00742 0.000279 0.011423 TMSB4X 7114 0.681513 8.2867 3.98562 0.000281 0.011442 SNX29 92017 -0.50966 6.267038 -3.98512 0.000281 0.011442 HLX 3142 0.659566 4.290565 3.981867 0.000284 0.011464 ZNF337 26152 -0.55771 3.830092 -3.98118 0.000285 0.011464 TPM3 7170 0.516779 8.922282 3.980386 0.000285 0.011464 L1TD1 54596 1.962932 2.298801 4.026595 0.000286 0.011464 SHPRH 257218 -0.48529 6.819506 -3.97706 0.000288 0.011514 SPPL2A 84888 0.559049 6.838542 3.976808 0.000289 0.011514 WBP1L 54838 0.390643 5.765173 3.974359 0.000291 0.011563 PAX6 5080 -0.64787 4.410064 -3.97137 0.000293 0.011632

UBC 7316 0.567537 7.4828 3.969567 0.000295 0.011659 MRPL47 57129 0.651942 2.75727 3.959797 0.000304 0.011969 RAD23B 5887 0.452365 5.512902 3.957153 0.000306 0.011993 CDC42 998 0.604508 7.493766 3.956566 0.000307 0.011993 MICB 4277 0.622615 4.542581 3.956092 0.000307 0.011993 FBXO6 26270 0.807976 3.118703 3.951978 0.000311 0.012105 ELOB 6923 0.930839 3.811607 3.957864 0.000313 0.012124 TMEM50A 23585 0.581994 6.553198 3.948861 0.000314 0.012124 H3F3B 3021 0.651332 7.453599 3.948448 0.000314 0.012124 FCGR3B 2215 2.473908 4.182117 4.020115 0.000318 0.012156 NDUFA11 126328 0.785125 3.918067 3.942759 0.000319 0.012156 SMIM30 401397 0.591357 3.109226 3.942643 0.00032 0.012156 GS1-279B7.1 1E+08 -0.94223 1.01809 -3.94231 0.00032 0.012156 FAM157A 728262 1.017321 5.987384 3.959115 0.00032 0.012156 SPATA5 166378 -0.66171 4.60079 -3.94086 0.000321 0.012156 S100A11 6282 0.872129 8.286619 3.945606 0.000322 0.012156 ZNF33B 7582 -0.64979 5.240867 -3.9397 0.000322 0.012156 MAPKAPK5 8550 -0.45233 6.286547 -3.93669 0.000325 0.01223 C20ORF96 140680 -0.91092 1.218522 -3.93483 0.000327 0.012263 SFMBT1 51460 -0.66922 3.134689 -3.92904 0.000333 0.01244 LCP1 3936 0.455027 11.09257 3.92734 0.000335 0.012468 CTSL 1514 0.953975 3.637872 3.929331 0.000337 0.012515 S100A12 6283 1.144693 8.0364 3.951689 0.000338 0.012528 KIAA1147 57189 -0.76041 4.423366 -3.92047 0.000341 0.012617 NUP188 23511 -0.54902 5.31689 -3.91843 0.000344 0.012658 TAS2R30 259293 -1.00855 2.624947 -3.91218 0.00035 0.01284 MLLT1 4298 0.62862 3.141803 3.911752 0.00035 0.01284 RTN3 10313 0.591674 7.950336 3.910054 0.000352 0.012846 COX6A1 1337 0.70989 5.216981 3.909698 0.000353 0.012846 PTPN1 5770 0.579995 4.935129 3.902941 0.00036 0.013002 C14ORF2 9556 0.625868 6.225455 3.902728 0.00036 0.013002 ZDHHC20 253832 0.737717 6.69517 3.902141 0.000361 0.013002 ZNF577 84765 -0.52798 3.84754 -3.9019 0.000361 0.013002 CLEC4D 338339 0.776732 4.680572 3.900921 0.000362 0.013004 BACE1 23621 -0.6153 4.395633 -3.89948 0.000364 0.013024 TOR4A 54863 0.660517 3.358708 3.89843 0.000365 0.013028 GAPDH 2597 0.766767 9.077052 3.896999 0.000366 0.013048 SH3PXD2B 285590 1.714713 3.218964 3.939316 0.00037 0.013148 LMCD1 29995 -0.90693 1.990076 -3.89259 0.000371 0.013148 GSR 2936 0.668752 5.547029 3.891605 0.000372 0.013151 ACTG1 71 0.687997 8.334136 3.890639 0.000373 0.013153 GLIPR2 152007 0.612638 7.069807 3.889031 0.000375 0.01318 UPF3A 65110 -0.45318 5.36082 -3.88544 0.000379 0.013285 EPM2A 7957 -0.4404 4.927673 -3.88312 0.000382 0.013341 DGAT2 84649 0.907168 3.91239 3.883182 0.000383 0.013352 RAB37 326624 -0.65512 4.029663 -3.88002 0.000385 0.013365 ZIK1 284307 -0.82891 2.086685 -3.87981 0.000385 0.013365

STK40 83931 0.563967 4.721675 3.878842 0.000387 0.013368 RNASE3 6037 1.477502 2.110976 3.888681 0.000394 0.013595 ADAMTSL3 57188 -0.49616 8.101962 -3.86854 0.000399 0.01371 TIMM8B 26521 0.651545 3.511851 3.86596 0.000402 0.013779 LBR 3930 0.663858 5.859814 3.862069 0.000406 0.013866 MMS22L 253714 -0.52111 5.596403 -3.86206 0.000406 0.013866 CSTA 1475 0.652094 6.541003 3.860911 0.000408 0.013877 CEP83 51134 -0.7146 4.144906 -3.85638 0.000413 0.014014 MAP3K8 1326 0.711817 4.281371 3.854984 0.000415 0.014014 LXN 56925 0.688945 1.729117 3.854957 0.000415 0.014014 RRP1 8568 -0.50797 5.12087 -3.85185 0.000419 0.014107 ZMAT1 84460 -0.56542 4.346647 -3.85017 0.000421 0.014141 AQP7 364 -1.26 2.412267 -3.8474 0.000424 0.01422 MRPS18C 51023 0.65553 4.282373 3.846291 0.000426 0.01423 IMPDH2 3615 -0.64804 3.092761 -3.84525 0.000427 0.014238 TSPO 706 0.868581 5.054255 3.849716 0.00043 0.014258 MFSD5 84975 0.796418 3.393166 3.842355 0.000431 0.014258 OR10G4 390264 -0.65758 4.019544 -3.84216 0.000431 0.014258 FAM135A 57579 -0.65263 5.217555 -3.83872 0.000435 0.014366 CD47 961 0.4538 6.751057 3.837555 0.000437 0.014366 TRIM21 6737 0.597301 5.167939 3.837048 0.000438 0.014366 ARHGEF26 26084 -0.53937 2.741025 -3.83174 0.000444 0.014545 LRRC37A11P 342666 -0.81791 1.367655 -3.83103 0.000445 0.014545 LEPROT 54741 0.530627 6.721612 3.829638 0.000447 0.014545 PPP1R11 6992 0.527251 5.274049 3.829465 0.000447 0.014545 DTX3L 151636 0.62434 7.077303 3.82728 0.00045 0.014588 GRIN2C 2905 -1.22029 0.751385 -3.82677 0.000451 0.014588 LSM6 11157 0.674458 4.197749 3.823644 0.000455 0.014687 TMEM9B 56674 0.396542 5.268608 3.822132 0.000457 0.014716 CDYL2 124359 0.72563 4.338011 3.820604 0.000459 0.014746 PRR13 54458 0.633389 6.696662 3.818154 0.000463 0.014762 ATP6AP1 537 0.658871 5.198572 3.817816 0.000463 0.014762 CHMP5 51510 0.565068 4.546835 3.817749 0.000463 0.014762 CARD6 84674 0.404357 5.622984 3.813632 0.000469 0.014906 XPO4 64328 -0.47413 5.27619 -3.81133 0.000472 0.01497 RABGAP1L 9910 -0.59713 7.106037 -3.80967 0.000474 0.015008 GNS 2799 0.492147 8.399324 3.807491 0.000478 0.015058 HIST2H2BE 8349 1.165646 4.339588 3.831843 0.000479 0.015058 C19ORF38 255809 0.600603 4.409529 3.805131 0.000481 0.015058 GBA 2629 0.574174 5.045985 3.805034 0.000481 0.015058 SLAMF7 57823 1.732289 5.295821 3.86449 0.000482 0.015058 CMTM6 54918 0.544645 6.749411 3.800976 0.000487 0.015175 RNF24 11237 0.4793 6.724395 3.79532 0.000495 0.015303 VAT1 10493 0.648728 3.340225 3.794703 0.000496 0.015303 ELOC 6921 0.488454 5.959791 3.793288 0.000498 0.015303 ANKRD26 22852 -0.88552 3.335061 -3.79262 0.000499 0.015303 TBC1D9 23158 -0.89231 5.606397 -3.80101 0.000499 0.015303

TPPP3 51673 -1.65471 1.43251 -3.80589 0.000499 0.015303 TUBA1B 10376 0.555176 7.096868 3.791037 0.000501 0.015303 MARCO 8685 1.35552 2.840882 3.820649 0.000501 0.015303 DST 667 -0.8341 6.094089 -3.79537 0.000501 0.015303 FAM89B 23625 0.696948 2.868855 3.782952 0.000513 0.015628 SPIN3 169981 -0.52383 6.279554 -3.78037 0.000517 0.01571 SOD2 6648 0.81225 11.41443 3.77523 0.000529 0.01604 GLUL 2752 0.764324 7.426938 3.770811 0.000534 0.016138 MYL12A 10627 0.602523 7.435911 3.768388 0.000536 0.016161 LEPR 3953 0.664889 3.379309 3.767038 0.000538 0.016187 LMO2 4005 0.531189 7.595379 3.762226 0.000546 0.016318 C10ORF53 282966 -1.14133 2.378276 -3.76157 0.000547 0.016318 VAPA 9218 0.502745 6.63551 3.761261 0.000547 0.016318 NDUFB3 4709 0.658068 4.06904 3.760129 0.000549 0.016318 STAG3L2 442582 -0.49941 4.523085 -3.76007 0.000549 0.016318 XYLB 9942 -0.8977 3.604581 -3.75959 0.00055 0.016318 TAF10 6881 0.759031 5.370668 3.754993 0.000559 0.016539 PKM 5315 0.549088 7.502303 3.753067 0.00056 0.016558 ARF1 375 0.687185 7.134022 3.750965 0.000564 0.016623 ITGA1 3672 0.737801 3.814435 3.741384 0.00058 0.017058 CD200R1 131450 -2.75887 1.467565 -3.78694 0.000582 0.017071 CDIP1 29965 -1.04384 3.164919 -3.74145 0.000583 0.017071 CD1A 909 -0.77691 2.301616 -3.73759 0.000587 0.017133 ADGRD1 283383 -0.96341 4.857151 -3.74247 0.000592 0.017184 DTX4 23220 -0.63489 5.871214 -3.7343 0.000592 0.017184 SNX3 8724 0.539581 5.277809 3.73323 0.000594 0.017184 SREK1 140890 -0.51783 6.59582 -3.73293 0.000595 0.017184 HIST1H1C 3006 1.048301 2.707083 3.740585 0.000595 0.017184 RTTN 25914 -0.50154 5.720162 -3.73199 0.000596 0.017184 ALOX5AP 241 1.34585 5.583975 3.77285 0.000598 0.017197 CNIH4 29097 0.815887 5.441059 3.73425 0.0006 0.017197 MCRIP1 348262 0.690871 2.685919 3.729462 0.000601 0.017197 TNFAIP6 7130 1.751017 1.256688 3.759241 0.000604 0.017259 SHKBP1 92799 0.611977 5.334363 3.723811 0.000611 0.017407 ANXA4 307 0.45513 6.354103 3.72059 0.000616 0.017519 CPED1 79974 -0.73722 4.573435 -3.71957 0.000618 0.017519 PIK3AP1 118788 0.481649 7.275517 3.719384 0.000619 0.017519 MYL12B 103910 0.580777 6.316843 3.717989 0.000621 0.017548 GSTO1 9446 0.70879 5.008576 3.717327 0.000622 0.017548 CHN2 1124 -0.52255 5.901405 -3.71478 0.000627 0.017641 BOD1 91272 -0.6164 3.405305 -3.71296 0.00063 0.017696 SLC25A20 788 0.774219 4.134004 3.711416 0.000634 0.017759 SDC4 6385 1.193731 1.229467 3.710242 0.000635 0.017761 ATP5E 514 0.664631 5.974815 3.70735 0.000641 0.017873 ZNF221 7638 -0.83638 1.690767 -3.70461 0.000646 0.017978 IPO5P1 1E+08 -0.96023 2.772008 -3.70272 0.00065 0.018039 MOB1A 55233 0.471939 8.518899 3.696853 0.000661 0.018312

ABCE1 6059 -0.42893 5.02409 -3.69344 0.000667 0.018456 ARPC4 10093 0.58659 6.942949 3.691481 0.000671 0.018522 BNC2 54796 -1.36842 1.970724 -3.68693 0.00068 0.018671 COX19 90639 -0.35721 4.770567 -3.68665 0.000681 0.018671 CSNK2B 1460 0.456323 5.47465 3.686248 0.000682 0.018671 SETD9 133383 -0.94564 1.94556 -3.68583 0.000682 0.018671 RAB1A 5861 0.464489 6.730863 3.685061 0.000684 0.018673 LHFPL2 10184 0.685321 6.098122 3.681351 0.000691 0.018812 NPIPA1 9284 -0.45037 5.752475 -3.68109 0.000692 0.018812 SHANK1 50944 -1.13901 2.326085 -3.68018 0.000694 0.018822 RRAGA 10670 0.485991 4.698621 3.678148 0.000698 0.018895 FAM200B 285550 0.576489 5.012598 3.676116 0.000702 0.018957 LSM10 84967 0.628083 2.913575 3.674785 0.000705 0.018957 SKA3 221150 0.73234 3.444971 3.674663 0.000705 0.018957 TDRD9 122402 0.809882 4.388716 3.675529 0.000706 0.018957 PTPRZ1 5803 -1.06838 2.781993 -3.67187 0.000711 0.019009 NUCB1 4924 0.673649 4.305712 3.671804 0.000711 0.019009 PSENEN 55851 1.310343 1.88671 3.673908 0.000724 0.019331 LRRK1 79705 -0.5872 10.31924 -3.66358 0.000728 0.019385 ANP32E 81611 0.573063 4.923111 3.662703 0.00073 0.019385 THNSL2 55258 -1.1413 1.780684 -3.66226 0.000731 0.019385 KCNC4 3749 -1.4817 4.850741 -3.68222 0.00075 0.019832 GRB2 2885 0.502449 7.241749 3.653015 0.000751 0.019832 SLC1A3 6507 1.444577 2.980037 3.678401 0.000754 0.019879 DPY30 84661 0.476941 3.710494 3.649247 0.000759 0.019946 MYO15B 80022 -0.64786 4.597316 -3.64894 0.00076 0.019946 SRGN 5552 0.649181 8.314582 3.640717 0.000778 0.020387 GLMP 112770 0.81027 4.460755 3.641135 0.000783 0.020471 PLA2G7 7941 -0.91266 5.774944 -3.64551 0.000784 0.020471 PLBD1 79887 0.858334 7.780282 3.643047 0.00079 0.020571 FAM198B 51313 0.687211 7.366064 3.634855 0.000791 0.020571 DAGLA 747 -0.86405 2.390166 -3.63314 0.000795 0.020632 CELP 1057 -0.79961 1.356886 -3.62975 0.000803 0.02077 ARRDC5 645432 -0.85395 2.218708 -3.62935 0.000804 0.02077 BORCS8 729991 0.435399 5.374637 3.628776 0.000806 0.02077 B4GALT1 2683 0.463588 7.24071 3.627437 0.000809 0.020809 SLC8A1 6546 0.517125 7.575506 3.626217 0.000812 0.020842 FTL 2512 0.697394 9.898709 3.624404 0.000816 0.02091 RHOG 391 0.724904 6.464788 3.623826 0.000818 0.020934 CTSD 1509 0.999324 6.023227 3.640995 0.000821 0.020958 RAB6A 5870 0.355925 6.785456 3.620317 0.000826 0.021021 KCNJ13 3769 -0.6824 2.693625 -3.61963 0.000827 0.021021 DDA1 79016 0.620884 3.384219 3.618973 0.000829 0.021021 PRDX5 25824 0.730017 4.164601 3.617974 0.000831 0.021021 THSD4 79875 -0.79726 2.343233 -3.61784 0.000832 0.021021 DBNDD2 55861 0.842891 2.549514 3.616573 0.000835 0.021057 NARS2 79731 -0.78789 2.688947 -3.61493 0.000839 0.021116

OSTM1 28962 0.362476 5.415133 3.612504 0.000844 0.021224 UQCR11 10975 0.785547 4.387214 3.614517 0.000847 0.021252 LAPTM4A 9741 0.532557 6.682866 3.607635 0.000856 0.021442 NINJ2 4815 0.749354 2.952578 3.606511 0.000859 0.021468 RAB44 401258 -0.81029 3.268813 -3.60516 0.000863 0.021468 LGR4 55366 -1.52351 1.698006 -3.60973 0.000864 0.021468 SYNGR2 9144 0.690946 5.374103 3.603923 0.000866 0.021468 WDR59 79726 -0.40353 4.733554 -3.60383 0.000866 0.021468 NUP153 9972 0.36639 5.989207 3.602865 0.000868 0.021468 WIPF2 147179 0.370963 6.150253 3.602475 0.000869 0.021468 TOGARAM2 165186 -0.42765 5.249504 -3.60141 0.000872 0.021468 ANKS3 124401 -0.5089 3.391535 -3.60126 0.000872 0.021468 ZNF546 339327 -0.49971 3.884734 -3.60036 0.000875 0.021477 WDR75 84128 -0.54357 4.812762 -3.59948 0.000877 0.021477 EPB41L2 2037 -0.69124 4.594195 -3.5986 0.000879 0.021477 PSMB2 5690 0.480886 6.040007 3.598492 0.000879 0.021477 EHD1 10938 0.746786 4.233882 3.597388 0.000882 0.021505 GLRX 2745 0.542966 7.687494 3.595595 0.000887 0.021576 UBE2B 7320 0.462264 5.193185 3.593724 0.000892 0.021653 POLD4 57804 0.603244 4.204272 3.589781 0.000902 0.02186 KCNJ15 3772 1.35267 5.652648 3.628451 0.000907 0.021912 DNHD1 144132 -0.47938 5.221734 -3.58766 0.000907 0.021912 FTCDNL1 348751 -0.86059 1.42413 -3.58697 0.000909 0.021915 NDUFA6 4700 0.5692 3.980931 3.583622 0.000918 0.022087 PPP2R1A 5518 0.460444 5.148046 3.581683 0.000923 0.02215 TBX19 9095 -0.5129 2.557091 -3.58134 0.000924 0.02215 L3HYPDH 112849 -0.67464 3.123038 -3.58024 0.000927 0.02218 FOXRED2 80020 -0.5246 3.686206 -3.57901 0.00093 0.022217 LAMTOR5 10542 0.624783 5.60718 3.575195 0.000941 0.022375 ANKRD20A8P729171 -1.7121 1.693952 -3.58414 0.000941 0.022375 MPPED2 744 -0.95935 2.608942 -3.57422 0.000943 0.022375 ARHGEF4 50649 -0.58304 2.518372 -3.57401 0.000944 0.022375 S100A10 6281 0.686377 7.580082 3.571143 0.000952 0.02252 CD55 1604 0.67722 7.770267 3.568852 0.000958 0.022599 SERPINB1 1992 0.679772 6.746036 3.568664 0.000958 0.022599 PAIP2B 400961 -0.70915 3.154584 -3.56792 0.00096 0.022606 MPHOSPH9 10198 -0.53871 5.127292 -3.56727 0.000962 0.022607 C5ORF60 285679 -0.90099 1.284738 -3.56664 0.000964 0.022607 YWHAH 7533 0.455641 4.799429 3.5644 0.00097 0.022713 KCNE3 10008 0.48808 6.158117 3.560941 0.00098 0.022899 NHS 4810 -0.90843 4.471973 -3.56182 0.000989 0.023022 NAPSA 9476 -1.15647 1.182257 -3.55783 0.000989 0.023022 ZNF530 348327 -0.63718 2.603421 -3.55623 0.000993 0.023086 NOTCH2NL 388677 -0.52955 8.541141 -3.55173 0.001006 0.023345 SEPHS2 22928 0.44643 4.872998 3.55056 0.00101 0.023376 TCN2 6948 1.343729 3.474049 3.577893 0.001011 0.023376 ATL2 64225 -0.40872 4.20133 -3.54602 0.001023 0.02353

CLEC1A 51267 -0.64473 2.470964 -3.5459 0.001023 0.02353 B3GNT4 79369 -0.97975 1.211986 -3.54582 0.001023 0.02353 LMNA 4000 0.837062 1.924058 3.545275 0.001025 0.02353 ATP6V1D 51382 0.39682 4.981006 3.541616 0.001036 0.023688 DUSP3 1845 0.465956 5.638951 3.541155 0.001037 0.023688 CD274 29126 2.512554 2.281886 3.5955 0.001037 0.023688 GOLT1B 51026 0.542761 3.475786 3.540188 0.00104 0.023699 TTC17 55761 -0.36743 7.043107 -3.5397 0.001042 0.023699 GNA15 2769 0.682632 3.60123 3.537485 0.001048 0.023807 CHMP3 51652 0.397017 6.492549 3.536901 0.00105 0.023807 DDX31 64794 -0.77352 2.084426 -3.53482 0.001056 0.023846 PPP6R1 22870 0.472337 4.514782 3.534309 0.001058 0.023846 SLC19A2 10560 -0.66354 2.156965 -3.5337 0.00106 0.023846 MTOR 2475 -0.3615 6.0336 -3.53358 0.00106 0.023846 OTUB2 78990 -1.10725 0.987482 -3.5333 0.001061 0.023846 NDUFS8 4728 0.60785 4.178165 3.530486 0.00107 0.023998 DYNLL1 8655 0.595925 5.906092 3.527357 0.001079 0.024157 FMO4 2329 0.838069 1.937958 3.52641 0.001082 0.024157 SELPLG 6404 0.667407 6.532079 3.526373 0.001082 0.024157 ANXA11 311 0.484393 6.265865 3.524936 0.001087 0.024185 NDUFB1 4707 0.652098 4.127443 3.524767 0.001087 0.024185 TAF13 6884 0.581479 2.838975 3.523148 0.001092 0.024231 EVI2A 2123 0.574013 6.5893 3.522865 0.001093 0.024231 CD164 8763 0.508774 6.869329 3.522318 0.001095 0.024231 PDLIM7 9260 0.694354 3.14628 3.521317 0.001098 0.024248 SH3GLB1 51100 0.513026 6.974937 3.519697 0.001103 0.024248 DCAF12 25853 0.393414 6.387047 3.51945 0.001104 0.024248 CATSPER2P1 440278 -0.77796 1.521124 -3.51924 0.001105 0.024248 LOC10050591.01E+08 -0.48285 6.054867 -3.51911 0.001105 0.024248 TDRD6 221400 -1.71587 3.438563 -3.54967 0.00111 0.024322 GUSBP1 728411 -0.94093 2.957374 -3.5093 0.001136 0.024854 MAN1C1 57134 -0.46633 4.163483 -3.50723 0.001143 0.024865 ATP5G2 517 0.60748 5.481378 3.507144 0.001143 0.024865 CREB5 9586 0.632809 8.074543 3.506817 0.001145 0.024865 HIST1H1E 3008 0.882281 3.830713 3.515815 0.001145 0.024865 IL11RA 3590 -0.78099 3.280057 -3.50621 0.001147 0.024865 MSMO1 6307 0.651379 3.464561 3.505392 0.001149 0.024882 MBNL2 10150 -0.58211 5.066855 -3.50428 0.001153 0.024919 MBOAT7 79143 0.806177 4.862731 3.50658 0.001165 0.025099 OSCP1 127700 -0.97005 0.841026 -3.50009 0.001167 0.025099 SUMO2 6613 0.476937 6.36618 3.498898 0.001171 0.025099 ARPC1A 10552 0.556968 3.485519 3.497366 0.001176 0.025099 FADD 8772 0.750102 2.461892 3.497359 0.001176 0.025099 UBE2G2 7327 -0.38851 5.822256 -3.4966 0.001178 0.025099 CCDC144B 284047 -0.50992 6.716972 -3.4966 0.001178 0.025099 CYB5RL 606495 -0.33541 5.721289 -3.49613 0.00118 0.025099 BAG3 9531 0.751376 2.111554 3.495528 0.001182 0.025099

C1RL 51279 0.677849 4.527439 3.495127 0.001183 0.025099 YIPF2 78992 0.729364 1.587191 3.495096 0.001184 0.025099 MGAT2 4247 0.439424 3.822256 3.494423 0.001186 0.025099 FGD6 55785 -0.48077 6.290685 -3.49427 0.001186 0.025099 SH3BGRL3 83442 0.787232 9.286895 3.497768 0.00119 0.025127 TMEM167B 56900 0.378112 5.824591 3.488781 0.001205 0.02539 ZNF485 220992 -0.89159 1.918864 -3.48852 0.001206 0.02539 ACTR1A 10121 0.361315 5.683004 3.486775 0.001212 0.025475 TM2D2 83877 0.537874 3.929091 3.485527 0.001216 0.025477 RFC3 5983 -0.73301 2.350462 -3.48513 0.001218 0.025477 NDUFV2 4729 0.411051 4.674812 3.485042 0.001218 0.025477 GOLGA8IP 283796 -1.22702 1.192191 -3.48435 0.00122 0.025487 HNRNPL 3191 0.379988 5.149468 3.482004 0.001229 0.02555 CTSK 1513 -0.60152 3.543709 -3.4818 0.001229 0.02555 AFG3L2 10939 -0.41518 4.292537 -3.48179 0.001229 0.02555 ATP6V1A 523 0.49751 7.128307 3.480832 0.001233 0.025554 PFN1P2 767846 -0.60454 3.980306 -3.48035 0.001234 0.025554 FFAR2 2867 1.052078 3.677055 3.492325 0.001235 0.025554 CAPNS1 826 0.647987 8.300726 3.47823 0.001242 0.025646 IRF2 3660 0.422461 6.077221 3.474724 0.001254 0.025863 SLC12A2 6558 -0.47477 4.461001 -3.47397 0.001257 0.025877 CRAT 1384 0.82185 2.507333 3.470669 0.001269 0.02606 ARF6 382 0.441357 6.478686 3.470146 0.001271 0.02606 CHMP2A 27243 0.625796 5.519523 3.469831 0.001272 0.02606 PYCARD 29108 0.758702 4.645775 3.471844 0.001276 0.026094 CENPO 79172 0.695924 3.133836 3.467608 0.00128 0.026141 HSPD1 3329 -0.39973 6.064447 -3.46708 0.001282 0.026141 SLC14A2 8170 -0.4719 3.891472 -3.46443 0.001292 0.026297 MRPL33 9553 0.591187 3.415872 3.460793 0.001305 0.026529 ZYX 7791 0.707128 6.049576 3.460409 0.001312 0.026633 DESI1 27351 0.629962 5.323313 3.455205 0.001326 0.02687 CFL2 1073 -0.56676 4.501565 -3.45247 0.001336 0.027037 SSBP1 6742 0.394878 5.596717 3.450848 0.001343 0.02712 KCNAB1 7881 -0.72398 2.953811 -3.45024 0.001345 0.027125 ITPR1 3708 -0.4745 7.220925 -3.44663 0.001359 0.027251 SFMBT2 57713 -0.70396 4.691827 -3.44654 0.001359 0.027251 UFD1 7353 0.455938 5.774949 3.445995 0.001361 0.027251 ARHGDIB 397 0.47301 9.101126 3.445958 0.001361 0.027251 LAPTM5 7805 0.526413 9.571082 3.445544 0.001363 0.027251 HLA-DQB2 3120 -1.13963 1.867169 -3.44533 0.001364 0.027251 CCDC122 160857 -0.44649 6.56074 -3.44371 0.00137 0.027321 WHAMMP3 339005 -0.37952 5.364188 -3.44329 0.001372 0.027321 COX7A2L 9167 0.435489 5.427815 3.442802 0.001374 0.027321 RAB11A 8766 0.613501 6.100641 3.442197 0.001376 0.027326 ZNF438 220929 0.526427 4.956795 3.440834 0.001381 0.027355 GSN 2934 0.622209 4.876269 3.440749 0.001382 0.027355 SGK494 124923 -0.47253 4.975214 -3.43775 0.001393 0.027547

KCNJ2 3759 1.059915 5.295297 3.457879 0.001403 0.027689 BSCL2 26580 0.893158 2.308183 3.434208 0.001407 0.02774 ABI1 10006 0.398351 6.296393 3.433098 0.001412 0.027785 PHLPP2 23035 -0.41501 4.292768 -3.43047 0.001422 0.027921 FAM53C 51307 0.315563 5.169337 3.430307 0.001423 0.027921 CABP1 9478 -0.88826 1.98037 -3.42858 0.00143 0.028016 TEX13C 1E+08 -1.21771 0.635745 -3.42747 0.001435 0.028062 UQCRQ 27089 0.777507 4.064557 3.429258 0.001439 0.028112 REXO2 25996 -0.57224 2.748189 -3.4257 0.001442 0.028118 NDUFB4 4710 0.670131 4.327174 3.424799 0.001445 0.028143 SLC5A3 6526 -0.49929 5.395654 -3.42433 0.001447 0.028143 CREG1 8804 0.476043 7.312823 3.422311 0.001456 0.028184 TMEM182 130827 -0.57721 7.477349 -3.42224 0.001456 0.028184 GSTK1 373156 0.3897 6.443833 3.421838 0.001458 0.028184 CDC42EP3 10602 0.496488 7.64948 3.421659 0.001458 0.028184 NAMPT 10135 1.24482 6.951472 3.455988 0.001461 0.028184 SCCPDH 51097 0.551205 3.408489 3.420641 0.001463 0.028184 SIRPD 128646 0.794996 3.181367 3.41948 0.001467 0.028235 SLC38A2 54407 0.471673 7.2364 3.418515 0.001471 0.028249 ARNTL2 56938 1.132929 3.666414 3.436267 0.001475 0.028249 LMAN2 10960 0.585992 4.325604 3.417415 0.001476 0.028249 GOLGA8R 1.01E+08 -0.4777 3.936763 -3.41722 0.001477 0.028249 NID1 4811 -1.1947 5.302115 -3.44124 0.001499 0.028632 TUBA1C 84790 0.481324 4.813634 3.41141 0.001501 0.028632 CHML 1122 -0.6068 4.907698 -3.41081 0.001504 0.028639 GPR137B 7107 0.615707 3.661124 3.408703 0.001513 0.028768 CCDC66 285331 -0.37588 4.95951 -3.4072 0.001519 0.028847 CHRNA10 57053 0.880813 0.725469 3.406317 0.001523 0.028878 SLC35G2 80723 -0.653 2.783344 -3.405 0.001529 0.028906 LHX4 89884 -0.62487 3.84411 -3.40454 0.001531 0.028906 ANKRD61 1E+08 -0.87216 0.95753 -3.40434 0.001532 0.028906 TMA16 55319 -0.455 3.673153 -3.40391 0.001533 0.028906 ZNF74 7625 -0.47485 2.893884 -3.40199 0.001542 0.029005 MAN2B2 23324 0.34582 5.359824 3.401581 0.001544 0.029005 TRMT13 54482 -0.61802 3.577897 -3.40116 0.001545 0.029005 FAM120AOS 158293 0.350881 5.87317 3.399899 0.001551 0.029066 TAGLN2 8407 0.677825 5.08666 3.399281 0.001554 0.029086 MOB1B 92597 0.371153 6.039711 3.397772 0.00156 0.029157 KLHL5 51088 -0.5132 5.385018 -3.39672 0.001565 0.029173 SPCS1 28972 0.534477 5.495859 3.396102 0.001568 0.029173 CAPN1 823 0.478036 4.922 3.396045 0.001568 0.029173 MKI67 4288 1.233023 2.498339 3.403035 0.001575 0.029243 COX7B 1349 0.625817 5.591514 3.394176 0.001576 0.029243 NAP1L1 4673 -0.37257 7.114557 -3.39268 0.001583 0.029296 SECISBP2 79048 -0.39206 6.299297 -3.39253 0.001583 0.029296 IFITM3 10410 1.592723 6.008085 3.437522 0.001586 0.029306 EPHA4 2043 -1.2918 0.908751 -3.39093 0.001591 0.029345

CHURC1 91612 0.462387 6.003727 3.389833 0.001596 0.029364 CINP 51550 0.465145 4.255325 3.38964 0.001596 0.029364 CD209 30835 -0.57206 3.060652 -3.38918 0.001599 0.029364 MAPK1IP1L 93487 0.411776 6.946342 3.387664 0.001605 0.029439 ITIH4 3700 -0.71021 2.561785 -3.38677 0.001609 0.029439 TLR8 51311 0.532893 7.94159 3.386768 0.001609 0.029439 TAPBP 6892 0.474398 8.220443 3.386131 0.001612 0.029451 SOCS5 9655 -0.40112 3.700611 -3.38444 0.00162 0.029521 ACOT13 55856 0.56443 4.858497 3.383634 0.001624 0.029521 SIRPA 140885 0.545047 7.271617 3.382934 0.001627 0.029521 LOC652276 652276 -0.37636 4.7511 -3.38281 0.001627 0.029521 KCNJ16 3773 -0.89034 1.147434 -3.3828 0.001628 0.029521 LAMP2 3920 0.42347 7.967118 3.381569 0.001633 0.029582 MAD2L1BP 9587 0.529413 2.858986 3.380394 0.001639 0.029638 IARS 3376 -0.52514 5.244926 -3.37909 0.001645 0.029706 UBA52 7311 0.562626 7.37402 3.377541 0.001652 0.029794 DCUN1D4 23142 -0.60843 4.061926 -3.37509 0.001663 0.029959 NKTR 4820 -0.42039 8.211877 -3.37324 0.001672 0.030012 SNX12 29934 0.52358 4.783457 3.372946 0.001673 0.030012 SNAP29 9342 0.419699 6.329005 3.371998 0.001678 0.030012 CYP2C9 1559 -0.76046 2.490204 -3.37175 0.001679 0.030012 ATP5I 521 0.617472 3.338615 3.371527 0.00168 0.030012 PCCA 5095 -0.54293 4.573053 -3.37151 0.00168 0.030012 COPS9 150678 0.645649 3.110996 3.37024 0.001686 0.030078 MALT1 10892 -0.48431 6.172123 -3.36942 0.00169 0.030107 SF3B6 51639 0.538964 3.870414 3.367364 0.0017 0.030189 G6PD 2539 0.717821 3.806954 3.36704 0.001701 0.030189 ACP6 51205 -0.61042 4.468969 -3.36698 0.001702 0.030189 FAM161A 84140 -0.6889 2.824403 -3.36416 0.001715 0.030373 DHRS11 79154 -1.04788 1.665466 -3.36385 0.001717 0.030373 FOXM1 2305 -0.60276 2.843811 -3.36314 0.00172 0.030392 APLP2 334 0.344967 9.551985 3.360519 0.001733 0.030544 UBQLN2 29978 0.404256 5.459716 3.360044 0.001735 0.030544 VOPP1 81552 0.588538 4.99468 3.359739 0.001737 0.030544 HHLA2 11148 -0.54786 3.876947 -3.35943 0.001738 0.030544 TRIM24 8805 0.392615 5.743775 3.356401 0.001753 0.030763 SMG8 55181 0.484394 3.929135 3.354963 0.00176 0.030808 TMPRSS3 64699 -0.78487 1.568104 -3.35492 0.00176 0.030808 ALCAM 214 0.669693 4.810502 3.353104 0.001769 0.03089 BSG 682 0.697741 4.794587 3.354218 0.00177 0.03089 RTL8C 8933 0.630611 2.720148 3.352373 0.001773 0.030904 AJAP1 55966 -0.93427 1.695252 -3.34927 0.001788 0.031115 SARNP 84324 0.576213 3.971795 3.348989 0.00179 0.031115 KLHDC1 122773 -0.74524 2.327233 -3.34775 0.001796 0.031168 SLC8B1 80024 0.437099 4.754268 3.347431 0.001798 0.031168 S100A6 6277 0.771973 6.725778 3.351799 0.001805 0.03123 SLC6A6 6533 0.487813 7.292515 3.345761 0.001806 0.03123

RAB14 51552 0.372879 6.086671 3.344203 0.001814 0.031249 SCGB3A2 117156 -1.02933 6.608839 -3.36103 0.001814 0.031249 ZNF532 55205 -0.45863 5.086593 -3.34412 0.001814 0.031249 C4ORF3 401152 0.430093 6.060533 3.342696 0.001822 0.03127 NME9 347736 -0.70651 2.987064 -3.34222 0.001824 0.03127 RCCD1 91433 -0.63933 2.355425 -3.34212 0.001825 0.03127 ZNF883 169834 -0.61859 2.12141 -3.34199 0.001825 0.03127 HIST1H2AG 8969 0.5769 2.055003 3.341406 0.001828 0.03128 TRAPPC1 58485 0.610792 5.136972 3.339117 0.00184 0.03144 RASEF 158158 -0.38787 6.530716 -3.33611 0.001856 0.03163 ACVR2B 93 -0.54988 3.587169 -3.33546 0.001859 0.03163 TUBGCP4 27229 -0.45048 5.149048 -3.33508 0.001861 0.03163 ANGEL1 23357 -0.5894 4.353986 -3.33497 0.001862 0.03163 ADAP2 55803 0.536628 4.935675 3.334623 0.001863 0.03163 XRCC5 7520 0.415396 7.301035 3.333773 0.001868 0.031664 ADAT2 134637 -0.71753 3.996936 -3.33242 0.001875 0.031708 ITGB7 3695 1.299915 3.165852 3.353382 0.001875 0.031708 POLR1E 64425 -0.58699 2.092437 -3.33132 0.001881 0.031757 FAM9B 171483 -0.75166 2.105335 -3.32922 0.001892 0.031904 GOLGA8N 643699 -0.44125 4.686812 -3.32874 0.001894 0.031905 PRELID3B 51012 0.451595 4.567007 3.327479 0.001901 0.031948 PTAFR 5724 0.509746 7.204945 3.327265 0.001902 0.031948 IL23A 51561 -0.89189 0.860548 -3.32687 0.001904 0.031948 MROH7 374977 -0.43595 3.894554 -3.32425 0.001918 0.032141 DSE 29940 0.587001 6.198656 3.32234 0.001928 0.03223 GJA1 2697 -0.86921 1.059513 -3.32233 0.001929 0.03223 JADE1 79960 -0.48251 5.694461 -3.31888 0.001947 0.032501 TRIM25 7706 0.43123 7.09561 3.317989 0.001952 0.03254 CCR1 1230 0.635851 6.100355 3.31641 0.001961 0.032642 POP5 51367 -0.47526 3.539395 -3.3159 0.001963 0.032644 MRPS16 51021 0.51064 4.882213 3.315462 0.001966 0.032644 TMED3 23423 0.514457 5.506617 3.31422 0.001973 0.032716 SUPV3L1 6832 -0.41402 4.248615 -3.31291 0.00198 0.032794 SAAL1 113174 -0.56632 3.238745 -3.31187 0.001986 0.032847 ARL6IP5 10550 0.311787 6.566022 3.308863 0.002002 0.033082 NBPF15 284565 -0.53492 6.000237 -3.3074 0.002011 0.033088 HSBP1 3281 0.660391 6.2088 3.307691 0.002011 0.033088 ATP6V0D1 9114 0.507889 6.865206 3.307121 0.002012 0.033088 ACTR3 10096 0.467363 8.445297 3.30625 0.002017 0.033088 ATP8A1 10396 -0.57284 4.739514 -3.30614 0.002018 0.033088 NPTN 27020 0.384724 5.217231 3.306069 0.002018 0.033088 LANCL2 55915 0.544047 3.603597 3.305271 0.002023 0.033095 DNAJC3 5611 0.406401 6.238509 3.305087 0.002024 0.033095 SCD 6319 1.080772 3.310026 3.317917 0.002029 0.033147 RNFT2 84900 -0.41 4.023627 -3.30252 0.002038 0.033249 ZNF154 7710 -0.43716 3.734036 -3.30182 0.002042 0.033272 DAZAP2 9802 0.42312 8.645328 3.298455 0.002061 0.033543

MAPK3 5595 0.625215 4.880118 3.296544 0.002072 0.03368 C2CD2 25966 -0.59698 4.809742 -3.29283 0.002094 0.033988 THOC1 9984 -0.48186 4.171422 -3.29091 0.002105 0.0341 VDR 7421 0.514953 4.467073 3.290667 0.002107 0.0341 LEAP2 116842 -0.60954 3.40159 -3.29012 0.00211 0.0341 TMEM8A 58986 0.611403 3.178134 3.289846 0.002111 0.0341 ARHGEF10L 55160 -0.67516 4.07919 -3.28861 0.002119 0.034153 P2RY2 5029 -0.69855 3.556648 -3.288 0.002122 0.034153 TUBA1A 7846 0.610338 6.372866 3.287955 0.002123 0.034153 TNR 7143 -0.87128 2.628781 -3.28731 0.002126 0.034171 NCF1C 654817 0.734826 4.702471 3.286245 0.002152 0.034502 SERF2 10169 0.590761 6.029516 3.282965 0.002152 0.034502 TNF 7124 0.946074 3.273863 3.290035 0.002156 0.034513 NBR1 4077 0.30766 7.5444 3.280839 0.002165 0.034621 GSDMB 55876 -0.49211 4.51413 -3.27909 0.002175 0.034742 TSHZ3 57616 0.558485 4.139609 3.278691 0.002178 0.034742 SAMD12 401474 -0.44551 7.652123 -3.27657 0.002191 0.034891 PER3 8863 -1.15059 2.833786 -3.28443 0.002193 0.034891 ARHGDIA 396 0.739919 4.288207 3.278346 0.002199 0.034934 EIF4E3 317649 0.560284 7.1079 3.274949 0.002201 0.034934 MRPL28 10573 0.742076 2.80156 3.274291 0.002205 0.034955 TMEM14EP 645843 -0.75463 4.020775 -3.27394 0.002218 0.03512 RNF181 51255 0.603693 3.960429 3.270681 0.002227 0.035221 RTN4 57142 0.457603 7.232031 3.269595 0.002234 0.035284 MAFB 9935 0.63177 5.696627 3.268834 0.002238 0.035316 MAPK8 5599 -0.45104 4.765008 -3.26824 0.002242 0.035331 OR5AN1 390195 -0.89393 2.235941 -3.26734 0.002248 0.035351 CDH26 60437 -0.83998 2.48532 -3.26716 0.002249 0.035351 HIST1H2BF 8343 1.227322 1.575847 3.277852 0.00226 0.035481 C12ORF49 79794 0.537617 5.042848 3.264599 0.002265 0.035481 MCCC2 64087 -0.38479 5.176869 -3.26453 0.002265 0.035481 RFLNB 359845 0.683337 5.036296 3.264499 0.002276 0.035598 RABAC1 10567 0.675366 3.115983 3.262351 0.002279 0.035598 C7ORF50 84310 0.600787 2.330187 3.262033 0.002281 0.035598 TMSB10 9168 0.671877 6.662166 3.262811 0.002284 0.035602 IPO11 51194 -0.66783 3.848291 -3.26046 0.002291 0.035668 B3GALNT2 148789 -0.46645 4.324545 -3.25967 0.002296 0.035703 ALKBH2 121642 -0.80659 1.469383 -3.25871 0.002302 0.035725 TOR1AIP1 26092 0.404154 6.684368 3.25859 0.002303 0.035725 NUDT21 11051 0.384561 5.510132 3.257253 0.002311 0.035792 FBP1 2203 0.54676 4.109111 3.256749 0.002315 0.035792 ADAL 161823 -0.75424 3.249362 -3.25662 0.002315 0.035792 FOXRED1 55572 -0.54442 3.66432 -3.25593 0.00232 0.035817 CHMP4B 128866 0.459814 5.196049 3.253321 0.002337 0.036035 DNAJC25-GN552891 0.9941 2.736434 3.25863 0.002346 0.036127 PFN1 5216 0.604742 7.561939 3.25128 0.00235 0.036153 TBC1D22B 55633 0.432488 2.736559 3.249521 0.002361 0.036286

JMJD7-PLA2G48681 -0.47573 4.153725 -3.24692 0.002378 0.036477 CCDC88C 440193 -0.46627 5.958057 -3.24677 0.002379 0.036477 DDX10 1662 -0.4803 4.786565 -3.24614 0.002384 0.036495 LRPAP1 4043 0.617364 6.088674 3.245432 0.002388 0.036495 MMP25 64386 1.393254 3.102336 3.271221 0.002389 0.036495 ANKRD36C 400986 -0.61491 3.600196 -3.24358 0.002401 0.036621 NDUFS7 374291 0.506486 4.573523 3.243219 0.002403 0.036621 CENPJ 55835 -0.64891 3.065848 -3.24236 0.002409 0.036665 LAT 27040 -0.41269 3.937819 -3.24163 0.002414 0.036695 RAC2 5880 0.551945 7.04396 3.240654 0.00242 0.036743 OLIG1 116448 -1.206 2.260479 -3.25045 0.002422 0.036743 ATP5D 513 0.457801 4.309389 3.237755 0.00244 0.036943 C1S 716 -0.64576 2.563774 -3.23744 0.002442 0.036943 STK31 56164 -0.64199 2.715543 -3.23708 0.002444 0.036943 RAB10 10890 0.559168 7.06536 3.236665 0.002447 0.036943 PLEKHG2 64857 0.591136 4.939773 3.236046 0.002451 0.036963 ACTG2 72 -0.67909 2.18798 -3.23347 0.002469 0.037183 NR1D2 9975 -0.99048 4.033243 -3.2405 0.00248 0.037314 PIM3 415116 0.934118 2.648547 3.23689 0.002483 0.037314 ANXA3 306 1.549682 2.525701 3.256788 0.002489 0.037356 RGL1 23179 0.814426 3.234963 3.230888 0.002499 0.037469 PLEKHO2 80301 0.564303 5.029152 3.228566 0.002502 0.037473 SLC35A4 113829 0.445994 5.071087 3.227684 0.002508 0.037521 GDI2 2665 0.393361 7.873534 3.22688 0.002514 0.037561 OGFR 11054 0.648204 3.278177 3.22449 0.002531 0.037766 QSOX1 5768 0.68707 5.367202 3.225473 0.00254 0.037838 TXN 7295 0.560814 3.842661 3.222962 0.002541 0.037838 NCAPD3 23310 -0.7 4.082171 -3.22079 0.002556 0.037953 DOCK1 1793 1.372708 2.143669 3.235372 0.002559 0.037953 SETD1B 23067 0.413115 5.197416 3.220297 0.00256 0.037953 COX17 10063 0.511521 2.849616 3.220207 0.002561 0.037953 ABHD17A 81926 0.643392 2.51795 3.218609 0.002572 0.038061 RIOX2 84864 -0.60344 3.879925 -3.21835 0.002574 0.038061 MAP7D3 79649 -0.50298 4.262716 -3.2172 0.002582 0.038138 LILRB2 10288 0.578294 8.046719 3.216215 0.002589 0.038198 SLC16A4 9122 -0.49238 3.228581 -3.21464 0.0026 0.03832 VIM 7431 0.568054 9.491149 3.211632 0.002622 0.038573 KCTD11 147040 0.480219 3.067913 3.21143 0.002623 0.038573 CCND3 896 0.709024 6.103842 3.214317 0.002627 0.03858 NDUFA1 4694 0.540786 5.236864 3.209675 0.002636 0.038672 HPS6 79803 0.589765 2.670851 3.208996 0.002641 0.038701 NPB 256933 -1.02717 1.710837 -3.20767 0.002651 0.038761 ZNF667 63934 -0.43369 3.780298 -3.20761 0.002651 0.038761 PPFIBP1 8496 -0.51477 3.876749 -3.20528 0.002668 0.03891 CDK5 1020 0.882349 2.356969 3.206934 0.002669 0.03891 LGI1 9211 -1.36025 1.875697 -3.20887 0.00267 0.03891 UBL5 59286 0.573607 5.363985 3.202507 0.002688 0.039123

ZNF182 7569 -0.43949 3.676003 -3.20201 0.002692 0.039123 DHX57 90957 -0.38604 5.80486 -3.20097 0.0027 0.039123 CD2BP2 10421 0.622233 4.182353 3.200885 0.002701 0.039123 OLFM1 10439 -1.81564 1.827719 -3.22073 0.002703 0.039123 ZNF461 92283 -1.11817 2.424526 -3.20511 0.002703 0.039123 OR5H14 403273 -0.48366 3.749155 -3.19743 0.002726 0.039258 OR10K1 391109 -0.46918 5.807962 -3.1973 0.002727 0.039258 HSP90AB1 3326 -0.50599 7.446357 -3.19726 0.002728 0.039258 ABI2 10152 -0.51674 5.922435 -3.19719 0.002728 0.039258 KLF12 11278 -2.05804 3.22673 -3.2335 0.002731 0.039258 GPR35 2859 0.770378 2.333207 3.196676 0.002732 0.039258 IGIP 492311 -0.48896 3.144608 -3.19624 0.002735 0.039258 BAK1 578 0.681103 2.817887 3.195964 0.002737 0.039258 LOC645513 645513 -0.43554 3.816755 -3.19554 0.00274 0.039258 XYLT1 64131 -0.56468 5.328459 -3.19527 0.002743 0.039258 ITGAM 3684 0.464275 8.732965 3.193807 0.002754 0.039355 TSPY26P 128854 -0.42562 2.852509 -3.19327 0.002758 0.039355 UTRN 7402 -0.49129 8.808741 -3.19317 0.002758 0.039355 NPHP3 27031 -0.39242 5.348145 -3.19163 0.00277 0.039477 CKAP4 10970 0.491745 5.490394 3.191014 0.002775 0.039501 MTHFD2 10797 0.480374 5.681241 3.190406 0.002779 0.039524 SELL 6402 0.617809 8.506517 3.189096 0.002789 0.039595 NDUFC1 4717 0.644551 2.584736 3.188955 0.00279 0.039595 NEU1 4758 0.44556 4.832163 3.188385 0.002795 0.039607 ZNF660 285349 -0.67948 3.250499 -3.18805 0.002797 0.039607 FAM160B1 57700 0.466376 5.076085 3.186973 0.002806 0.03968 PPHLN1 51535 -0.29871 6.393568 -3.1863 0.002811 0.039704 TXN2 25828 0.453476 4.125702 3.185963 0.002813 0.039704 TALDO1 6888 0.551404 6.519452 3.18507 0.00282 0.039758 TSSK3 81629 -1.18462 0.87085 -3.18462 0.002824 0.039764 EMBP1 647121 -0.32484 5.598375 -3.18406 0.002828 0.039769 SEL1L3 23231 1.42598 2.435245 3.203771 0.00283 0.039769 LASP1 3927 0.358756 7.339757 3.180831 0.002853 0.040021 USP49 25862 -0.37026 5.056374 -3.18069 0.002854 0.040021 SNRPB2 6629 0.421669 4.336036 3.179479 0.002864 0.04008 MAF 4094 0.923659 3.184033 3.184655 0.002865 0.04008 ATP5F1 515 0.414242 6.587374 3.178483 0.002872 0.040098 SRP14 6727 0.449103 6.753303 3.178414 0.002872 0.040098 FAM83C 128876 -0.79993 1.378905 -3.17752 0.002879 0.040153 DGLUCY 80017 -0.4254 5.168159 -3.17459 0.002903 0.040433 ZSCAN12 9753 -0.48946 2.995939 -3.17333 0.002913 0.040525 CD22 933 -0.76265 3.213541 -3.17298 0.002915 0.040525 GOLGA4 2803 -0.41693 6.431982 -3.17158 0.002927 0.040596 SLC18B1 116843 -0.76905 3.751016 -3.17378 0.002927 0.040596 ATP5H 10476 0.436153 5.136134 3.170988 0.002931 0.040616 IGF2BP2 10644 -0.8564 3.110944 -3.16943 0.002944 0.040745 UQCR10 29796 0.651665 3.70267 3.167718 0.002958 0.040893

SERPINB10 5273 1.105896 2.333601 3.173405 0.002968 0.04099 CSTB 1476 0.589752 5.665543 3.165872 0.002973 0.041013 QPCT 25797 0.526116 5.088099 3.163946 0.002988 0.041105 ATP6V1E1 529 0.342693 5.501163 3.163863 0.002989 0.041105 BCL3 602 0.827761 3.381043 3.166193 0.002992 0.041105 MCFD2 90411 0.317745 7.026815 3.163504 0.002992 0.041105 COMMD5 28991 0.573752 3.028685 3.162758 0.002998 0.041145 CHD1L 9557 -0.53383 3.93889 -3.16147 0.003009 0.041218 ASAP3 55616 -0.50404 1.98304 -3.16101 0.003012 0.041218 ARPC5L 81873 0.503961 3.325503 3.160949 0.003013 0.041218 ANKRD22 118932 1.378676 2.619205 3.182396 0.003039 0.041523 AGPAT2 10555 0.641476 2.114463 3.157479 0.003042 0.041523 IFNAR2 3455 0.443281 5.927001 3.155264 0.00306 0.041731 PID1 55022 -1.33192 5.103081 -3.18566 0.003072 0.041843 NRM 11270 0.5412 4.215636 3.152644 0.003082 0.041943 MRPL44 65080 0.361164 3.651685 3.151327 0.003093 0.042015 IDH3A 3419 -0.35727 4.820156 -3.15124 0.003094 0.042015 GAS6 2621 0.854624 1.326321 3.148762 0.003115 0.042196 SLC31A2 1318 0.63377 5.08364 3.148846 0.003116 0.042196 APMAP 57136 0.517664 5.193326 3.148519 0.003117 0.042196 AIF1 199 0.498412 8.353277 3.147405 0.003126 0.04228 RBM4B 83759 -0.54148 4.250324 -3.14523 0.003145 0.042487 KIAA0355 9710 -0.35766 5.020659 -3.14482 0.003149 0.042491 TMEM176A 55365 2.211433 5.594903 3.186025 0.003163 0.042648 THAP2 83591 0.634068 2.655021 3.141575 0.003177 0.04278 SIGLEC10 89790 0.743798 6.189104 3.144365 0.003202 0.043071 NCF4 4689 0.532501 5.159948 3.138167 0.003206 0.043088 CIC 23152 0.870815 3.416438 3.14272 0.003209 0.043088 FRRS1 391059 -0.90644 3.834347 -3.14369 0.003214 0.04309 CAP1 10487 0.37454 8.343048 3.137024 0.003216 0.04309 ZNF266 10781 -0.5513 5.596845 -3.13545 0.00323 0.043147 TMEM108 66000 -0.97114 1.604865 -3.13542 0.00323 0.043147 C12ORF40 283461 -0.54215 2.096517 -3.1354 0.00323 0.043147 ENGASE 64772 -0.80131 2.979362 -3.135 0.003234 0.043149 MXRA7 439921 1.036683 3.905244 3.149144 0.003239 0.043168 KIAA0895L 653319 0.600187 4.197522 3.13314 0.00325 0.043279 SIGLEC5 8778 0.630646 4.170406 3.132324 0.003258 0.043331 PRPF39 55015 -0.597 4.010879 -3.13161 0.003264 0.043371 DYNC2H1 79659 -1.08588 3.047611 -3.13845 0.00327 0.043385 NPC2 10577 0.520807 6.861723 3.130739 0.003272 0.043385 TMEM185B 79134 0.513249 2.946421 3.129573 0.003282 0.043478 ZNF202 7753 -0.51218 3.131855 -3.12854 0.003291 0.043546 OR11A1 26531 -0.64681 2.805589 -3.12825 0.003294 0.043546 SCN2B 6327 -0.74647 2.586693 -3.12736 0.003302 0.043599 SORBS3 10174 -0.94615 1.715308 -3.12705 0.003305 0.043599 PPP1CC 5501 0.353998 7.095372 3.125174 0.003322 0.043747 SLC25A37 51312 0.689567 6.090034 3.127916 0.003325 0.043747

USP28 57646 -0.52981 4.491183 -3.12455 0.003327 0.043747 REXO1L1P 254958 -0.76225 7.263832 -3.13056 0.003336 0.043747 ZFAND3 60685 0.347119 4.829684 3.12349 0.003337 0.043747 TRIM7 81786 0.885333 3.337416 3.129934 0.003339 0.043747 C17ORF49 124944 0.543276 3.688757 3.123198 0.003339 0.043747 SLC35G1 159371 -0.69557 1.785014 -3.12252 0.003346 0.043784 PHTF2 57157 -0.53805 4.26597 -3.12184 0.003352 0.043821 FRY 10129 -0.44259 6.8329 -3.12129 0.003357 0.043841 NLN 57486 -0.35965 5.668312 -3.12015 0.003367 0.043891 LRRC19 64922 -0.54801 1.888452 -3.11971 0.003371 0.043891 KIAA2013 90231 0.466363 4.466234 3.119485 0.003373 0.043891 ATP5J2 9551 0.555084 4.599243 3.119396 0.003374 0.043891 TUBGCP2 10844 0.408409 4.724169 3.118253 0.003385 0.043927 LAMB2 3913 -1.22298 2.283408 -3.12458 0.003388 0.043927 PRR5L 79899 0.963494 2.829846 3.122497 0.00339 0.043927 HS2ST1 9653 0.609475 4.072394 3.117253 0.003394 0.043927 CREBZF 58487 -0.48826 4.787374 -3.11725 0.003394 0.043927 LAMC1 3915 1.618108 3.161587 3.146767 0.003423 0.044244 PRPF38B 55119 -0.33256 6.592626 -3.11387 0.003425 0.044244 ESRP2 80004 -0.82154 1.703748 -3.11295 0.003434 0.044254 SASH3 54440 0.518179 6.369502 3.112697 0.003436 0.044254 OST4 1E+08 0.489998 5.972935 3.112691 0.003436 0.044254 ATP5G3 518 0.542057 6.109923 3.108782 0.003473 0.044681 ZMAT2 153527 0.415474 4.539824 3.108094 0.003479 0.04472 NFIL3 4783 0.672525 4.147571 3.108006 0.003487 0.044737 RUFY3 22902 -0.47124 4.862894 -3.10723 0.003487 0.044737 CPEB4 80315 0.464949 6.579603 3.106465 0.003495 0.044785 TMEM176B 28959 2.501569 5.373299 3.148627 0.003502 0.044832 ZCWPW1 55063 -0.46293 4.355296 -3.10504 0.003508 0.044832 LOC10028951E+08 -1.26727 1.342282 -3.10726 0.003511 0.044832 PTPRJ 5795 0.408461 7.682538 3.104623 0.003512 0.044832 AOX3P-AOX1.07E+08 -0.75982 1.216582 -3.10385 0.00352 0.044882 ZNF101 94039 0.438696 5.096797 3.103254 0.003525 0.04491 KCNJ6 3763 -0.39454 4.559064 -3.10207 0.003537 0.045011 MGST1 4257 0.526718 4.96847 3.101392 0.003543 0.045049 PSMD8 5714 0.433536 4.684793 3.10091 0.003548 0.045064 TXNL4A 10907 0.457046 4.692844 3.099804 0.003558 0.045122 HSD3B7 80270 0.495999 2.633785 3.099714 0.003559 0.045122 HMGXB3 22993 -0.55883 4.432694 -3.09779 0.003578 0.045313 CHIC1 53344 -0.97903 1.64486 -3.09391 0.003616 0.045747 CMC2 56942 0.386259 5.656653 3.093338 0.003621 0.045773 SRD5A3 79644 0.56775 4.092889 3.092019 0.003634 0.045892 GPSM3 63940 0.617666 5.620036 3.091849 0.003638 0.045899 GPRIN3 285513 1.102477 5.325046 3.114802 0.003647 0.045962 PTCD3 55037 -0.34201 6.224732 -3.09038 0.00365 0.045962 NLE1 54475 -0.70721 2.62773 -3.0895 0.003659 0.046027 OR10J1 26476 -0.58804 1.880218 -3.0888 0.003666 0.046068

TSR1 55720 -0.60319 4.539795 -3.08786 0.003675 0.046141 ATAT1 79969 -0.5068 3.009412 -3.0869 0.003685 0.046217 SUPT4H1 6827 0.419173 5.543846 3.086036 0.003693 0.04628 ITGB5 3693 -1.32798 0.747264 -3.08684 0.003702 0.046341 MAP4K1 11184 -0.65738 4.053238 -3.08306 0.003723 0.046531 BMS1P1 399761 -0.41606 5.745279 -3.08296 0.003724 0.046531 ANAPC13 25847 0.450361 3.655729 3.081927 0.003735 0.046609 APBA1 320 -1.21279 2.513239 -3.08583 0.003738 0.046609 CDK7 1022 0.470605 3.493257 3.080672 0.003747 0.046625 SNRPD1 6632 0.468438 5.424151 3.080506 0.003749 0.046625 ALDOA 226 0.596346 7.056228 3.079704 0.003757 0.046625 SRP19 6728 0.361788 6.374777 3.079644 0.003758 0.046625 LOC728755 728755 -0.65012 1.324936 -3.07939 0.00376 0.046625 VPS26A 9559 0.520707 4.509487 3.079372 0.003761 0.046625 DCTN6 10671 0.438369 4.087986 3.078505 0.003769 0.04669 RAB3IP 117177 -0.44312 5.162882 -3.07595 0.003795 0.046968 SUMO1 7341 0.395278 5.114954 3.074714 0.003808 0.047017 FAM129B 64855 0.746822 3.386434 3.076389 0.003812 0.047017 LUC7L 55692 -0.45327 5.960293 -3.07395 0.003816 0.047017 MCMBP 79892 0.329055 5.947396 3.073521 0.00382 0.047017 ITPRIP 85450 0.548292 4.662383 3.07316 0.003824 0.047017 SURF4 6836 0.442351 4.628744 3.072964 0.003826 0.047017 PSMC1 5700 0.403885 6.020782 3.072786 0.003828 0.047017 ADCK1 57143 -0.45402 2.871765 -3.07275 0.003828 0.047017 MPO 4353 0.729117 2.990564 3.071907 0.003837 0.047079 ARHGAP1 392 0.474674 5.810475 3.070926 0.003847 0.047143 RALGAPA1P 26134 -0.79611 2.864723 -3.0707 0.00385 0.047143 TAF12 6883 0.409981 3.833334 3.069777 0.003859 0.047216 P2RY1 5028 0.910627 2.781649 3.072104 0.003868 0.047277 LINC00933 1.01E+08 -0.70934 1.422546 -3.06791 0.003879 0.047287 EPPIN 57119 -0.52134 3.506175 -3.06743 0.003884 0.047287 TMED2 10959 0.351606 6.204112 3.067393 0.003884 0.047287 TTF2 8458 -0.38415 5.194718 -3.06735 0.003884 0.047287 SSR4 6748 0.5591 5.034302 3.067125 0.003887 0.047287 LMO7 4008 -0.64977 3.343487 -3.06547 0.003904 0.047454 KLHDC7B 113730 1.590775 2.238651 3.091458 0.003917 0.047566 ADAMTS16 170690 -0.8051 2.416648 -3.06321 0.003928 0.047655 PRLR 5618 -0.82327 4.067688 -3.06466 0.003939 0.047738 NRAS 4893 0.380218 5.787937 3.061844 0.003943 0.047741 CACNB2 783 -0.59394 3.592685 -3.05972 0.003965 0.047907 NFE2 4778 0.669854 5.394981 3.062277 0.003965 0.047907 PSMB5 5693 0.44185 3.934408 3.059514 0.003967 0.047907 CLN8 2055 -0.41138 5.357888 -3.05848 0.003978 0.047996 MGAM 8972 1.597288 4.590496 3.093587 0.003991 0.048098 SAR1A 56681 0.443065 5.813444 3.056486 0.004 0.048127 TBC1D10A 83874 -0.58428 2.967539 -3.05643 0.004 0.048127 DPH3 285381 0.376355 4.429341 3.055674 0.004009 0.04818

POLR1C 9533 -0.33444 4.991496 -3.05534 0.004012 0.04818 ZNF783 1E+08 -0.52311 3.064914 -3.05279 0.00404 0.048425 NOL9 79707 -0.32423 5.778813 -3.05242 0.004044 0.048425 PDLIM2 64236 0.522075 4.833224 3.052417 0.004044 0.048425 MAP1LC3B 81631 0.453452 5.947403 3.051268 0.004056 0.04853 RSU1 6251 0.448541 5.493052 3.050064 0.004069 0.048604 C3AR1 719 0.846576 5.901695 3.062846 0.004071 0.048604 LAMTOR2 28956 0.598468 3.034704 3.049674 0.004074 0.048604 ARHGAP22 58504 -0.54809 4.450105 -3.04901 0.004081 0.048646 NOM1 64434 -0.43079 4.522746 -3.04755 0.004097 0.048665 ACTR2 10097 0.370299 9.086984 3.047413 0.004099 0.048665 OXNAD1 92106 -0.54401 3.94131 -3.04717 0.004101 0.048665 TMEM269 1E+08 -0.53204 2.099954 -3.04677 0.004106 0.048665 SPATA13 221178 0.521337 5.959031 3.046715 0.004106 0.048665 C9ORF64 84267 0.331623 4.122309 3.046536 0.004108 0.048665 PARP9 83666 0.787446 7.091981 3.055105 0.004109 0.048665 RBM6 10180 -0.41446 6.61618 -3.04389 0.004138 0.04896 TEN1 1E+08 -0.81705 1.421211 -3.04127 0.004167 0.04926 ATP5O 539 0.477249 5.371517 3.039659 0.004185 0.049429 SERPINA1 5265 0.589428 8.529267 3.039105 0.004191 0.049457 S100A4 6275 0.634044 6.361709 3.039593 0.004203 0.049533 FOLR3 2352 1.35227 3.746021 3.067066 0.004205 0.049533 RHOBTB3 22836 0.779526 3.465964 3.038845 0.004211 0.049557 TOR1A 1861 0.286286 5.448071 3.034774 0.00424 0.049854 NANP 140838 -0.4343 2.895781 -3.03412 0.004247 0.049895

Schulert GS, et al. Ann Rheum Dis 2020;0:1–9. doi: 10.1136/annrheumdis-2020-217470