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Elevated Microrna-145 Inhibits the Development of Oral Squamous Cell Carcinoma Through Inactivating ERK/MAPK Signaling Pathway by Down-Regulating
Bioscience Reports (2019) 39 BSR20182214 https://doi.org/10.1042/BSR20182214 Research Article Elevated microRNA-145 inhibits the development of oral squamous cell carcinoma through inactivating ERK/MAPK signaling pathway by down-regulating HOXA1 Downloaded from http://portlandpress.com/bioscirep/article-pdf/39/6/BSR20182214/846268/bsr-2018-2214.pdf by guest on 01 October 2021 Junhai Ding1,*, Dubin Sun2,* and Pengfeng Xie3 1Department of Stomatology, Affiliated Hospital of Jining Medical University, Jining 272100, P.R. China; 2Department of Stomatology, Zoucheng People’s Hospital, Zoucheng 273500, P.R. China; 3Special Functions Section, Jinan Stomatological Hospital, Jinan 250001, P.R. China Correspondence: Pengfeng Xie ([email protected]) Background: Oral cancer is one of the most frequent solid cancers worldwide, and oral squamous cell carcinoma (OSCC) constitutes approximately 90% of oral cancers. The dis- covery of reliable prognostic indicators would be a potential strategy for OSCC treatment. In the present study, we aim to explore the underlying mechanism by which microRNA-145 (miR-145) affected OSCC. Methods: Forty-eight patients diagnosed with OSCC were en- rolled to obtain the OSCC tissues and adjacent normal tissues. The targeting relationship between miR-145 and Homeobox A1 (HOXA1) was verified. In order to assess the effects of miR-145 in OSCC and the detailed regulatory mechanism, the SCC-9 cell line was adopted, in which expression of miR-145 and HOXA1 were altered by transfection. Then, a series of in vitro and in vivo experiments were performed to evaluate the cell viability, migration, in- vasion, and tumor growth. Results: miR-145 was poorly expressed and HOXA1 was highly expressed in OSCC. -
Lithofacies Palaeogeography of the Late Permian Wujiaping Age in the Middle and Upper Yangtze Region, China
Journal of Palaeogeography 2014, 3(4): 384-409 DOI: 10.3724/SP.J.1261.2014.00063 Lithofacies palaeogeography and sedimentology Lithofacies palaeogeography of the Late Permian Wujiaping Age in the Middle and Upper Yangtze Region, China Jin-Xiong Luo*, You-Bin He, Rui Wang School of Geosciences, Yangtze University, Wuhan 430100, China Abstract The lithofacies palaeogeography of the Late Permian Wujiaping Age in Middle and Upper Yangtze Region was studied based on petrography and the “single factor analysis and multifactor comprehensive mapping” method. The Upper Permian Wujiaping Stage in the Middle and Upper Yangtze Region is mainly composed of carbonate rocks and clastic rocks, with lesser amounts of siliceous rocks, pyroclastic rocks, volcanic rocks and coal. The rocks can be divided into three types, including clastic rock, clastic rock-limestone and lime- stone-siliceous rock, and four fundamental ecological types and four fossil assemblages are recognized in the Wujiaping Stage. Based on a petrological and palaeoecological study, six single factors were selected, namely, thickness (m), content (%) of marine rocks, content (%) of shallow water carbonate rocks, content (%) of biograins with limemud, content (%) of thin- bedded siliceous rocks and content (%) of deep water sedimentary rocks. Six single factors maps of the Wujiaping Stage and one lithofacies palaeogeography map of the Wujiaping Age were composed. Palaeogeographic units from west to east include an eroded area, an alluvial plain, a clastic rock platform, a carbonate rock platform where biocrowds developed, a slope and a basin. In addition, a clastic rock platform exists in the southeast of the study area. Hydro- carbon source rock and reservoir conditions were preliminarily analyzed based on lithofacies palaeogeography. -
Coal Mine Methane Country Profiles, June 2015
Disclaimer The U.S. Environmental Protection Agency does not: a) Make any warranty or representation, expressed or implied, with respect to the accuracy, completeness, or usefulness of the information contained in this report, or that the use of any apparatus, method, or process disclosed in this report may not infringe upon privately owned rights; or b) Assume any liability with respect to the use of, or damages resulting from the use of, any information, apparatus, method, or process disclosed in this report. CMM Country Profiles CONTENTS Units of Conversions .............................................................................................................................................. i Executive Summary .............................................................................................................................................. ii Global Overview at a Glance ................................................................................................................................. ii Introduction ............................................................................................................................................................ 1 Purpose of the Report ............................................................................................................................................. 2 Organization of the Report ................................................................................................................................... 2 1 Argentina ...................................................................................................................................................... -
Federal Register/Vol. 83, No. 221/Thursday, November 15, 2018
Federal Register / Vol. 83, No. 221 / Thursday, November 15, 2018 / Notices 57421 with regard to this program, which had Public Comment DEPARTMENT OF COMMERCE the lowest rate in the Preliminary Determination among the programs Case briefs or other written comments International Trade Administration may be submitted to the Assistant alleged to be inconsistent with the SCM [A–570–073] Agreement. In so doing, we intend to Secretary for Enforcement and limit the corresponding offset to the Compliance no later than seven days Antidumping Duty Investigation of dumping margin (if one is found) in the after the date on which the last Common Alloy Aluminum Sheet From companion antidumping duty verification report is issued in this the People’s Republic of China: investigation, which best fulfills our investigation. Rebuttal briefs, limited to Affirmative Final Determination of statutory mandate ‘‘to ensure that the issues raised in case briefs, may be Sales at Less-Than-Fair Value party does not obtain a more favorable submitted no later than five days after result by failing to cooperate than if it the deadline date for case briefs.20 AGENCY: Enforcement and Compliance, had cooperated fully,’’ 18 and induce Pursuant to 19 CFR 351.309(c)(2) and International Trade Administration, future cooperation by companies in (d)(2), parties who submit case briefs or Department of Commerce. investigations where the petitioners rebuttal briefs in this investigation are SUMMARY: The Department of Commerce allege the existence of programs encouraged to submit with each (Commerce) determines that common potentially inconsistent with the SCM argument: (1) A statement of the issue; alloy aluminum sheet (common alloy Agreement. -
Fushun Four Page
FUSHUN MINING GROUP CO., LTD. L IAONING PROVINCE Opportunities for Investment in Coal Mine Methane Projects A major coal producer, the Fushun Mining Group Company, Ltd. has one producing underground mine and one open-pit mine. Total coal production in the mining area is about 6 million tonnes of coal annually. The underground mine, Laohutai, drains about 100 million cubic meters (more than 3.5 billion cubic feet) of methane annually, and methane production from surface boreholes has also begun. Significant opportunity exists for expanding recovery and utilization of methane from surface and underground boreholes. The Fushun Mining Group Company, Ltd. seeks investment for expanding the production of methane from surface boreholes and combining it with a portion of the methane recovered from the Laohutai mine to meet the energy needs of the nearby city of Shenyang. Fushun Mining Group seeks investment from China and abroad to for the proposed coal mine methane development project described in this brochure. OVERVIEW OF THE FUSHUN MINING GROUP COMPANY LTD. CHINA Fushun Mining Area LIAONING The Fushun Mining Group Company Ltd. (informally known as the Fushun Mining Group) is a large state-owned coal enterprise with 26 subsidiaries. Located in the city of Fushun in northeastern China’s Liaoning Province, it is about 45 km from Shenyang, the capital of the province, and 126 km from Anshan, a major iron and steel manufacturing center. Although the Fushun area has produced coal for more than 100 years, an estimated 800 million tonnes of recoverable reserves remain. The Fushun Mining Group has total assets of 4.7 billion yuan ($US 566 million). -
A Qualitative and Comprehensive Analysis of Caries Susceptibility for Dental Fluorosis Patients
antibiotics Review A Qualitative and Comprehensive Analysis of Caries Susceptibility for Dental Fluorosis Patients Qianrui Li 1 , Jiaqi Shen 1, Tao Qin 1, Ge Zhou 1, Yifeng Li 1, Zhu Chen 2 and Mingyun Li 1,* 1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China; [email protected] (Q.L.); [email protected] (J.S.); [email protected] (T.Q.); [email protected] (G.Z.); [email protected] (Y.L.) 2 Key Laboratory of Oral Disease Research, School of Stomatology, Zunyi Medical University, Zunyi 563000, China; [email protected] * Correspondence: [email protected] Abstract: Dental fluorosis (DF) is an endemic disease caused by excessive fluoride exposure during childhood. Previous studies mainly focused on the acid resistance of fluorotic enamel and failed to reach a consensus on the topic of the caries susceptibility of DF patients. In this review, we discuss the role of DF classification in assessing this susceptibility and follow the “four factors theory” in weighing the pros and cons of DF classification in terms of host factor (dental enamel and saliva), food factor, bacteria factor, and DF treatment factor. From our analysis, we find that susceptibility is possibly determined by various factors such as the extent of structural and chemical changes in fluorotic enamel, eating habits, fluoride levels in diets and in the oral cavity, changes in quantity and quality of saliva, and/or oral hygiene. Thus, a universal conclusion regarding caries susceptibility might not exist, instead depending on each individual’s situation. -
Coal Mine Methane Country Profiles, Chapter 7, June 2015
7 China 7.1 Summary of Coal Industry 7.1.1 ROLE OF COAL IN CHINA Coal accounts for 69 percent of total national energy consumption in China (EIA, 2014a). Ranking first in the world in production of coal, China exported 16.5 million tonnes (Mmt) of coal in 2011; a sharp decline from a peak of 108.8 Mmt in 2003 (EIA, 2014b). Historically, a net coal exporter, China became a net coal importer in 2009 for the first time in more than two decades (EIA, 2014a). Table 7-1 provides recoverable reserve and recent coal production data for China. Table 7-1. China’s Coal Reserves and Production Sub- Anthracite & Total bituminous & Global Rank Indicator Bituminous (million Lignite (# and %) (million tonnes) tonnes) (million tonnes) Estimated Proved Coal Reserves 62,200 52,300 114,500 3 (12.9%) (2011) Annual Coal Production (2012) 3,510.2 141.5 3,651.8 1 (46.3%) Note: Numbers may not add due to rounding Source: EIA (2014b) As shown in Figure 7-1, the following major coal basins are located in four regions of China (USEPA, 1996): . Sanjuang-Mulinghe, Songliao, Donhua-Fushun, and Hongyang-Hunjiang basins in the Northeast; . Taixing-Shandou, Qinshui, Daning, Ordos, Hedong, Yuxi, Xuhuai, and Huainan basins in the North; . Chuannon-Qianbei, Huayingshan-Yongrong, and Liapanshui basins in the South; and . Tarim, Qaidam, and Junggar basins in the Northwest. CMM Country Profiles 63 CHINA Figure 7-1. China’s Coal Fields Source: Liu (2006) 7.1.2 STAKEHOLDERS Table 7-2 identifies some of the key stakeholders for coal mine methane (CMM) project development in China. -
Hydrochemical Characteristics and Formation Mechanism of Groundwater in West Zoucheng City, Shandong Province, China
Hydrochemical Characteristics and Formation Mechanism of Groundwater in West Zoucheng City, Shandong Province, China Hao Chen North-West University Jiading Wang ( [email protected] ) Northwest University Fei Zhang Shandong Provincial Lunan Geology and Exploration Institute Yaxing Zhou Shandong Provincial Lunan Geology and Exploration Institute Chunying Xia Shandong Provincial Lunan Geology and Exploration Institute Wenliang Zhang Shandong Provincial Lunan Geology and Exploration Institute Xianzhou Meng Shandong Provincial Lunan Geology and Exploration Institute Jia Meng Shandong Provincial Lunan Geology and Exploration Institute Research Article Keywords: Karst groundwater, Hydrochemical characteristics, Formation mechanism, Principal component analysis, Zoucheng city Posted Date: July 20th, 2021 DOI: https://doi.org/10.21203/rs.3.rs-722323/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/16 Abstract The groundwater in the western part of Zoucheng is an important water source for domestic, industrial and agricultural use in Zoucheng. Understanding its hydrochemical characteristics and formation mechanism is of great signicance to the sustainable development and utilization of groundwater. In this study, 36 water samples were collected during wet and dry seasons, and the hydrochemical components K+, Na+, Ca2+, Mg2+, Cl-, 2- - - - SO4 , HCO3 , NO3 , F , TH and TDS were analyzed. Graphic method, correlation analysis and principal component analysis were applied to explore the hydrochemical characteristics and evolution mechanism of groundwater in the study area. The results show that: (1) The orders of the anion and 2+ + 2+ + - 2- - - - cation concentrations of karst groundwater and pore groundwater are Ca >Na >Mg >K and HCO3 >SO4 >Cl >NO3 >F . -
EMD Oil Shale Committee
EMD Oil Shale Committee EMD Oil Shale Committee Annual Report – 2015 Alan Burnham, Chair April 29, 2015 Vice-Chairs: Dr. Lauren Birgenheier (Vice-Chair – University) University of Utah Mr. Ronald C. Johnson (Vice-Chair – Government) U.S. Geological Survey Dr. Mariela Araujo (Vice-Chair – Industry) Shell International Exploration and Production Highlights Progress on oil shale continued in both the United States and around the world, but with a greater sense of urgency in countries with lesser quantities of conventional energy sources. New production capacity was brought on line in Estonia and China, and plans for production moved forward in Jordan. However, reductions and delays in development are starting to appear, particularly in the United States, due to the low price of crude oil. The current status is in flux, but it is too early to know whether we are seeing a repeat of the 1980s. In the U.S., the Utah Division of Water Quality issued a groundwater permit to Red Leaf Resources, which now has the go-ahead to establish a small-scale commercial production system based on the EcoShale process as a joint venture with Total. A challenge by environmental groups was settled by allowing access to groundwater monitoring data. However, that project is now delayed by a year or more, and the time will be used to accelerate design optimization. TomCo received temporary approval to establish a commercial operation using the EcoShale process 15 miles from the Red Leaf operation. Enefit is making progress getting permits for development of its private lands in Utah and successfully resolved a potential environmental roadblock by working with local officials, who created a conservation plan for a potentially rare plant. -
Chinacoalchem
ChinaCoalChem Monthly Report Issue May. 2019 Copyright 2019 All Rights Reserved. ChinaCoalChem Issue May. 2019 Table of Contents Insight China ................................................................................................................... 4 To analyze the competitive advantages of various material routes for fuel ethanol from six dimensions .............................................................................................................. 4 Could fuel ethanol meet the demand of 10MT in 2020? 6MTA total capacity is closely promoted ....................................................................................................................... 6 Development of China's polybutene industry ............................................................... 7 Policies & Markets ......................................................................................................... 9 Comprehensive Analysis of the Latest Policy Trends in Fuel Ethanol and Ethanol Gasoline ........................................................................................................................ 9 Companies & Projects ................................................................................................... 9 Baofeng Energy Succeeded in SEC A-Stock Listing ................................................... 9 BG Ordos Started Field Construction of 4bnm3/a SNG Project ................................ 10 Datang Duolun Project Created New Monthly Methanol Output Record in Apr ........ 10 Danhua to Acquire & -
Argus China Petroleum News and Analysis on Oil Markets, Policy and Infrastructure
Argus China Petroleum News and analysis on oil markets, policy and infrastructure Volume XII, 1 | January 2018 Yuan for the road EDITORIAL: Regional gasoline The desire to avoid tax has been a far more significant factor underlying imports markets are so far unmoved by a of mixed aromatics than China’s octane deficit. potential fall in Chinese exports The government has announced plans to make it impossible to buy or sell owing to stricter tax enforcement gasoline without producing a complete invoice chain showing that consumption tax has been paid, from 1 March. And gasoline refining margins shot to nearly $20/bl, their highest since mid-2015. Of course, Beijing has tried to stamp out tax evasion in the gasoline market many times before. But, if successful, this poses Mixed aromatics imports 2017 an existential threat — to trading companies and the blending firms that use ’000 b/d Mideast mixed aromatics to produce gasoline outside the refining system, largely avoiding US Gulf 4.39 the Yn2,722/t ($51/bl) tax collected on gasoline produced by refineries. Around 22.59 300,000 b/d of gasoline is produced this way. And that has caused the surplus that forces state-owned firms to market their costlier fuel overseas. Europe But there is little panic outside south China, where most blending takes place. 77.69 The Singapore market is discounting any threat that a crackdown on tax avoidance might choke off Chinese exports — gasoline crack spreads fell this month. China’s prices are now above those in Singapore, yet its gasoline exports show no sign of letting up. -
Loan Agreement
OFFICIAL DOCUMENTS Public Disclosure Authorized LOAN NUMBER 8927-CN Loan Agreement Public Disclosure Authorized (Guizhou Aged Care System Development Program) between PEOPLE'S REPUBLIC OF CHINA and Public Disclosure Authorized INTERNATIONAL BANK FOR RECONSTRUCTION AND DEVELOPMENT Public Disclosure Authorized LOAN AGREEMENT AGREEMENT dated as of the Signature Date between PEOPLE'S REPUBLIC OF CHINA ("Borrower") and INTERNATIONAL BANK FOR RECONSTRUCTION AND DEVELOPMENT ("Bank"). The Borrower and the Bank hereby agree as follows: ARTICLE I - GENERAL CONDITIONS; DEFINITIONS 1.01. The General Conditions (as defined in the Appendix to this Agreement) apply to and form part of this Agreement. 1.02. Unless the context requires otherwise, the capitalized terms used in this Agreement have the meanings ascribed to them in the General Conditions or in the Appendix to this Agreement. ARTICLE II- LOAN 2.01. The Bank agrees to lend to the Borrower the amount of three hundred five million seven hundred thousand Euro (E305,700,000), as such amount may be converted from time to time through a Currency Conversion ("Loan"), to assist in financing the program described in Schedule 1 to this Agreement ("Program"). 2.02. The Borrower may withdraw the proceeds of the Loan in accordance with Section IV of Schedule 2 to this Agreement. All withdrawals from the Loan Account shall be deposited by the Bank into an account specified by the Borrower and acceptable to the Bank. 2.03. The Front-end Fee is one quarter of one percent (0.25%) of the Loan amount. 2.04. The Commitment Charge is one quarter of one percent (0.25%) per annum on the Unwithdrawn Loan Balance.