Read PDF Edition
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Customer Vision Report (MED 4)
MED 4 (11/25/2020) CUSTOMER VISION REPORT Purpose: Use this form to request vision examination information from your ophthalmologist or optometrist. Instructions: Complete the Customer Information section and have your Ophthalmologist/Optometrist complete the Vision Examination section. The vision examination must be conducted within 90 days prior to submission of the report to DMV. Mail the completed report to the address above. Questions can be referred to Medical Review Services, 804-367-6203. Acceptable standards of vision for safe driving are determined by the Code of Virginia and DMV under the guidance of the Medical Advisory Board. Note: Any charges incurred for the completion of this form are your responsibility. CSC STAFF Do NOT send MED 4 back with daily work unless there is an ocular condition or customer cannot be licensed due to a MED 6 calculation. CUSTOMER INFORMATION (To be completed by customer PRIOR to vision examination) If you change either your residence/home address or mailing address to a non-Virgina address, your driver license or photo identification (ID) card may be cancelled. NAME (last) (first) (mi) (suffix) CUSTOMER NUMBER (from your driver license) or SSN RESIDENCE/HOME ADDRESS BIRTHDATE (mm/dd/yyyy) CITY STATE ZIP CODE CITY OR COUNTY OF RESIDENCE MAILING ADDRESS (if different from above) CITY STATE ZIP CODE DAYTIME TELEPHONE NUMBER VISION EXAMINATION (to be completed by Ophthalmologist/Optometrist) FIRST EXAMINATION DATE MOST RECENT EXAMINATION DATE Does the patient have any visual/ocular condition(s) that could affect the ability to drive a motor vehicle? YES NO If YES, indicate condition below. -
214622Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 214622Orig1s000 MULTI-DISCIPLINE REVIEW Summary Review Office Director Cross Discipline Team Leader Review Clinical Review Non-Clinical Review Statistical Review Clinical Pharmacology Review NDA214622 Multi‐disciplinary Review and Evaluation Infigratinib (Truseltiq) NDA/BLA Multi‐disciplinary Review and Evaluation FDA review was conducted in conjunction with other regulatory authorities under a regular ORBIS. While the application review is completed by the FDA, the application is still under review at the other regulatory agencies (Health Canada and Therapeutic Goods Administration). Disclaimer: In this document, the sections labeled as “Data” and “The Applicant’s Position” are completed by the Applicant, which do not necessarily reflect the positions of the FDA. Application Type NDA Application Number(s) 214622 Priority or Standard Priority Submit Date(s) September 29, 2020 Received Date(s) September 29, 2020 PDUFA Goal Date May 29, 2021 Division/Office OOD/DO3 Review Completion Date Please check electronic date stamp Established Name Infigratinib Trade Name Truseltiq Pharmacologic Class FGFR Inhibitor Code name BGJ398 Applicant QED Therapeutics, Inc. Formulation(s) Oral capsule Dosing Regimen 125 mg orally once daily for 21 consecutive days followed by 7 days off therapy, in 28‐day cycles Applicant Proposed The treatment of adult patients with previously treated, Indication(s)/Population(s) unresectable locally advanced or metastatic cholangiocarcinoma with FGFR2 gene fusions or other rearrangement as detected by an FDA approved test. Recommendation on Approval Regulatory Action Recommended For the treatment of adults with previously treated, Indication(s)/Population(s) unresectable locally advanced or metastatic (if applicable) cholangiocarcinoma with an FGFR2 fusion or other rearrangement as detected by an FDA‐approved test. -
KITS: Good Growth, Solid Unit Economics, Aligned Management
Matt Koranda, (949) 720-7119 [email protected] Gustavo Gala, (949) 720-7116 [email protected] Sales (800) 933-6830, Trading (800) 933-6820 COMPANY NOTE | EQUITY RESEARCH | February 16, 2021 Consumer: DTC & Disruptors Initiation of Coverage Kits Eyecare Ltd. | KITS.TO - C$8.13 - TSX | Buy Stock Data 52-Week Low - High C$7.55 - C$10.20 KITS: Good Growth, Solid Unit Economics, Shares Out. (mil) 31.00 Aligned Management; Initiate at Buy Mkt. Cap.(mil) C$252.03 3-Mo. Avg. Vol. NA With its digital-first approach to selling contacts and prescription glasses/ 12-Mo.Price Target C$13.00 sunglasses, we see a long runway of growth ahead as Kits capitalizes on a Cash (mil) C$43.2 steady shift of the USD $35bn North American eyewear market into online Tot. Debt (mil) C$11.0 channels (only 13% sold online in 2021, under-penetrated vs. most consumer Revenue (C$ millions) categories). We like Kits' dual-pronged strategy of converting customers into high-visibility auto-ship programs while driving glasses growth, as these Yr Dec —2020— —2021E— —2022E— improve customer-level profitability. Moreover, management has a track- Curr Curr 1Q NA 22.5E 32.4E record of success and owns ~70% of shares. 2Q NA 32.1E 45.3E ■ 3Q 20.2A 31.8E 44.9E We initiate coverage on Kits Eyecare at Buy with a $13 PT. Kits 4Q 19.6A 30.6E 41.2E offers vision testing, prescription renewals, and products such as contact YEAR 74.5A 116.9E 163.9E lenses and eyeglasses through its website, kits.com. -
Update on Pathologic Diagnosis of Corneal Infections and Inflammations
[Downloaded free from http://www.meajo.org on Tuesday, March 27, 2012, IP: 41.234.93.234] || Click here to download free Android application for this journal Eye Pathology Update Update on Pathologic Diagnosis of Corneal Infections and Inflammations Geeta K. Vemuganti, Somasheila I. Murthy1, Sujata Das2 ABSTRACT Access this article online Website: One of the most frequent types of corneal specimen that we received in our pathology laboratory www.meajo.org is an excised corneal tissue following keratoplasty. Several of these cases are due to corneal DOI: infections or the sequelae, like corneal scar. Advances in the histological and molecular 10.4103/0974-9233.90128 diagnosis of corneal infections and inflammations have resulted in rapid and accurate diagnosis Quick Response Code: of the infectious agent and in the overall understanding of the mechanisms in inflammatory diseases of the cornea. This review provides an update of histopathological findings in various corneal infections and inflammations. Key words: Corneal Histopathology, Corneal Infiltrate, Corneal Inflammations, Microbial Keratitis, Moorens’ Ulcer INTRODUCTION Corneal infections often commence as epithelial ulceration followed by stromal infiltration by polymorphonuclear (PMN) eratitis is an important cause of ocular morbidity worldwide, and lymphomononuclear cells leading to destruction of Bowman’s Kthe outcome of which depends on early diagnosis, prompt layer, stromal necrosis and perforation of the Descemet’s 1 and effective treatment and various host and agent factors. Some membrane in severe cases. Suppurative infections like bacterial of the common causes of infectious keratitis include bacterial, and fungal lead to infiltrates in anterior 2/3 of stroma and abscess fungal, viral, and protozoan, the diagnosis of which is made on formation. -
A Large Vision Network Means There's Always a Provider In
Vision Plans Network Options A large vision network means there’s always a provider in sight. UnitedHealthcare knows how important it is to find a provider you can trust who meets your lifestyle, eye care and eyewear needs. With our large national eye care network, Spectera Eyecare Networks, you can choose to get more personalized care from a private practice. Or, take advantage of the convenience retail chains offer with evening and weekend hours. Either way, we’re focused on providing you with a better eye care experience. Well-known practices and brands in our large national network include: • 20/20 Vision Center • Eye Boutique • 3 Guys Optical • EyeCare Associates • AccurateOptical • Eye Express • All About Eyes • eyecarecenter Making it easier for you • Allegany Eyecare • Eyeglass World to find a provider. • America’s Best • EyeMart Express To find the provider who best • Bard Optical • Eyetique meets your needs, login to • BJ’s Optical • For Eyes myuhcvision.com or call • Boscov’s Optical • General Vision Services 1-800-638-3120. • Clarkson Eyecare • H. Rubin Vision Centers Some providers or locations may not participate in your plan. • Co/Op Optical • Henry Ford OptimEyes • Cohen’s Fashion Optical • Horizon Eye Care • Costco Optical • Houston Eye Associates • Crown Vision Center • JC Penney Optical • Dr. Travel Family Eye Care • Midwest Vision Centers CONTINUED • MyEyeDr. • Standard Optical • National Optometry • Stanton Optical • National Vision • Sterling Optical • Nationwide Vision • SVS Vision • NUCROWN • Target Optical (not available for • Optical Shop at Meijer all members) • Optyx • Texas State Optical • Ossip Optometry • The Eye Gallery • Pearle Vision • The Hour Glass • Rosin Eyecare • Thoma & Sutton Optical • RX Optical • Today’s Vision • Sam’s Club • Virginia Eye Institute • Schaeffer Eye Centers • Vision4Less • Sears Optical (not available for • Visionmart Express all members) • Visionworks • See Inc. -
Boosting Learning Efficacy with Non-Invasive Brain Stimulation in Intact and Brain-Damaged Humans
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Behavioral/Cognitive Boosting learning efficacy with non-invasive brain stimulation in intact and brain-damaged humans F. Herpich1,2,3, F. Melnick, M.D.4 , S. Agosta1 , K.R. Huxlin4 , D. Tadin4 and L Battelli1,5,6 1Center for Neuroscience and Cognitive Systems@UniTn, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto (TN), Italy 2Center for Mind/Brain Sciences, University of Trento, 38068 Rovereto, Italy 3kbo Klinikum-Inn-Salzach, Gabersee 7, 83512, Wasserburg am Inn, Germany 4Department of Brain and Cognitive Sciences, Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, NY, USA 5Berenson-Allen Center for Noninvasive Brain Stimulation and Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02215 Massachusetts, USA 6Cognitive Neuropsychology Laboratory, Harvard University, Cambridge, MA, USA https://doi.org/10.1523/JNEUROSCI.3248-18.2019 Received: 28 December 2018 Revised: 10 April 2019 Accepted: 8 May 2019 Published: 27 May 2019 Author contributions: F.H., M.D.M., K.H., D.T., and L.B. designed research; F.H., M.D.M., and S.A. performed research; F.H., M.D.M., and D.T. analyzed data; F.H., M.D.M., and L.B. wrote the first draft of the paper; M.D.M., S.A., K.H., D.T., and L.B. edited the paper; K.H., D.T., and L.B. wrote the paper. Conflict of Interest: The authors declare no competing financial interests. The present study was funded by the Autonomous Province of Trento, Call “Grandi Progetti 2012”, project “Characterizing and improving brain mechanisms of attention — ATTEND (FH, SA, LB), “Fondazione Caritro — Bando Ricerca e Sviluppo Economico” (FH), NIH (DT, MM and KRH: R01 grants EY027314 and EY021209, CVS training grant T32 EY007125), and by an unrestricted grant from the Research to Prevent Blindness (RPB) Foundation to the Flaum Eye Institute. -
Migraine Triggered Seizures and Epilepsy Triggered Headache and Migraine Attacks: a Need for Re-Assessment
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central J Headache Pain (2011) 12:287–288 DOI 10.1007/s10194-011-0344-2 COMMENTARY Migraine triggered seizures and epilepsy triggered headache and migraine attacks: a need for re-assessment Paul T. G. Davies • C. P. Panayiotopoulos Received: 5 April 2011 / Accepted: 8 April 2011 / Published online: 24 April 2011 Ó The Author(s) 2011. This article is published with open access at Springerlink.com In this issue of the Journal, Belcastro and associates review Migralepsy terminology and classification issues for migralepsy, hem- icrania epileptica, post-ictal and ictal headache [1]. They According to the ICHD-II 1.5.5, ‘‘migraine-triggered sei- raise key points such as ictal headache and visual seizures zure (sometimes referred to as migralepsy)’’ denotes an are often misdiagnosed as migraine, ‘‘migralepsy’’ is unli- epileptic seizure that occurs ‘‘during or within one hour kely to exist and an ‘‘epilepsy-migraine sequence’’ is much after a migraine aura’’ [3]. However, the evidence of this more common and well documented than the dominant ‘‘migraine-seizure’’ sequence is weak and the proposed view of a ‘‘migraine-epilepsy sequence’’. Their relevant criterion of 1 h gap between the end of the ‘‘aura’’ and the proposals need appropriate attention by the committee of start of an epileptic seizure is entirely arbitrary the international classification of headache disorders Migralepsy is an old term derived from migra(ine) and (ICHD) as well as the physicians in their clinical practice (epi)lepsy, coined by Dr Douglas Davidson, but mainly because of the consequences that misdiagnosis may have on attributed to Lennox and Lennox, which we quote, ‘‘a patients. -
Mechanisms Compensating for Visual Field Restriction in Adolescents With
Eye (2012) 26, 1437–1445 & 2012 Macmillan Publishers Limited All rights reserved 0950-222X/12 www.nature.com/eye 1;2 3;4 1 Mechanisms L Jacobson , F Lennartsson , T Pansell ,GO¨ qvist CLINICAL STUDY Seimyr2 and L Martin2;5 compensating for visual field restriction in adolescents with damage to the retro-geniculate visual system 1Eye Unit, Department of Neuropaediatrics, Astrid Lindgren Children’s Hospital, Karolinska University Abstract Hospital, Stockholm, Background To describe visual field (VF) Conclusion Congenital and later-acquired Sweden outcome in three adolescents with damage to homonymous VF defects may, at least in 2 the optic radiation and to focus on young subjects, be compensated for by Department of Clinical Neuroscience, mechanisms that may compensate the scanning. Exotropia may compensate VF Ophthalmology and Vision, practical functional limitations of VF defects. defects and, therefore, the VF should be Karolinska Institutet, Design Descriptive, prospective multi-case tested before strabismus surgery. Stockholm, Sweden study in a hospital setting. Eye (2012) 26, 1437–1445; doi:10.1038/eye.2012.190; Participants Three teenagers with cerebral published online 21 September 2012 3Department of Medical visual dysfunction because of damage to the Physics, Karolinska University Hospital, retro-geniculate visual pathways. Keywords: VF defects; retro-geniculate visual Stockholm, Sweden Methods Best-corrected visual acuity and system; compensating mechanisms; eye alignment were assessed. Visual field adolescents 4Department of function was tested with Goldmann Neuroradiology, Karolinska perimetry, and with Rarebit, Humphrey University Hospital, Introduction Visual Field Analyzer and Esterman Stockholm, Sweden computerized techniques. Fixation was Brain damage has become the most common 5School of Health and registered with video oculography during cause of visual impairment in children in Welfare, Ma¨ lardalen 1–3 Rarebit examination. -
Neuro-Ophthalmic Side Effects of Molecularly Targeted Cancer Drugs
Eye (2018) 32, 287–301 © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 0950-222X/18 www.nature.com/eye 1,2,3 4 Neuro-ophthalmic side MT Bhatti and AKS Salama REVIEW effects of molecularly targeted cancer drugs Abstract The past two decades has been an amazing time culminated in indescribable violence and in the advancement of cancer treatment. Mole- unspeakable death. However, amazingly within cularly targeted therapy is a concept in which the confines of war have risen some of the specific cellular molecules (overexpressed, greatest advancements in medicine. It is within mutationally activated, or selectively expressed this setting—in particular World War II with the proteins) are manipulated in an advantageous study of mustard gas—that the annals of cancer manner to decrease the transformation, prolif- chemotherapy began touching the lives of eration, and/or survival of cancer cells. In millions of people. It is estimated that in 2016, addition, increased knowledge of the role of the over 1.6 million people in the United States will immune system in carcinogenesis has led to the be diagnosed with cancer and over a half a development of immune checkpoint inhibitors million will die.1 The amount of money being to restore and enhance cellular-mediated anti- spent on research and development of new tumor immunity. The United States Food and cancer therapies is staggering with a record $43 Drug Administration approval of the chimeric billion dollars spent in 2014. Nearly 30% of all monoclonal antibody (mAb) rituximab in 1997 registered clinical trials on the clinicaltrials.gov 1Department of for the treatment of B cell non-Hodgkin lym- website pertain to cancer drugs. -
Elementary Visual Hallucinations, Blindness, and Headache in Idiopathic Occipital Epilepsy: Diverentiation from Migraine
536 J Neurol Neurosurg Psychiatry 1999;66:536–540 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.66.4.536 on 1 April 1999. Downloaded from SHORT REPORT Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: diVerentiation from migraine C P Panayiotopoulos Abstract also fundamental symptoms often with the This is a qualitative and chronological same sequence of events in occipital seizures.1−9 analysis of ictal and postictal symptoms, This is a systematic prospective qualitative frequency of seizures, family history, study of the characteristics of elementary visual response to treatment, and prognosis in hallucinations, blindness, and headache in nine patients with idiopathic occipital epi- idiopathic occipital epilepsy. lepsy and visual seizures. Ictal elementary visual hallucinations are stereotyped for Methods each patient, usually lasting for seconds. These are detailed elsewhere.910 Patients with They consist of mainly multiple, bright occipital seizures were prospectively evaluated coloured, small circular spots, circles, or and followed up from 1973. Nine patients with balls. Mostly, they appear in a temporal idiopathic occipital epilepsy with visual halluci- hemifield often moving contralaterally or nations (IOEVH) had: in the centre where they may be flashing. (a) Incontrovertible clinical evidence of oc- They may multiply and increase in size in cipital seizures with or without secondarily the course of the seizure and may progress generalisation. to other non-visual occipital seizure (b) Normal physical, neurological, and men- symptoms and more rarely to extra- tal states and high resolution MRI. They all had detailed interviews, seven com- occipital manifestations and convulsions. 9 Blindness occurs usually from the begin- pleted a purposely designed questionnaire, ning and postictal headache, often indis- and eight provided drawings of their visual hal- tinguishable from migraine, is common. -
Case 1:21-Cv-06966 Document 1 Filed 08/18/21 Page 1 of 38
Case 1:21-cv-06966 Document 1 Filed 08/18/21 Page 1 of 38 UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF NEW YORK 1-800 CONTACTS, INC. ) ) Plaintiff, ) ) v. ) Case No. ________________ ) JAND, INC. d/b/a WARBY PARKER ) ) Jury Trial Demanded Defendant. ) COMPLAINT Plaintiff 1-800 Contacts, Inc. (“1-800 Contacts”) makes the following allegations in support of its Complaint against Defendant JAND, Inc., d/b/a Warby Parker (“Warby Parker”): NATURE OF THE ACTION 1. This is an action to stop and remedy Defendant Warby Parker’s continuing trademark infringement, unfair competition, and deceptive advertising practices. Plaintiff 1-800 Contacts is a well-known pioneer in the online contact lens marketplace. Over the past three decades, 1-800 Contacts has expended hundreds of millions of dollars on advertising, marketing, and promotion to cultivate strong consumer recognition of its brand, services, and trademarks. 2. 1-800 Contacts’ investments and decades-long commitment to its customers has paid off, as the company now serves millions of customers. Indeed, between June 1, 2020, and June 30, 2021, alone, the 1800contacts.com website averaged more than 1.5 million unique visitors monthly. Case 1:21-cv-06966 Document 1 Filed 08/18/21 Page 2 of 38 3. 1-800 Contacts is an online—rather than a brick-and-mortar—retailer, so millions of customers and prospective customers reach 1-800 Contacts by navigating to the 1800contacts.com website. In an effort to navigate to its online store at the 1800contacts.com website, many consumers type “1800 Contacts,” “1 800 Contacts,” “1800contacts.com,” “1800contacts,” or other of 1-800 Contacts’ trademarks as search terms in search engines such as Google. -
Anterior Segment Surgery and Complications CATARACT EXTRACTION and INTRAOCULAR LENS IMPLANTATION
10 Anterior Segment Surgery and Complications CATARACT EXTRACTION AND INTRAOCULAR LENS IMPLANTATION Complications PENETRATING KERATOPLASTY Complications Correction of Astigmatism in a Corneal Graft LAMELLAR KERATOPLASTY SUPERFICIAL KERATECTOMY EXCIMER LASER PHOTOTHERAPEUTIC KERATECTOMY CONJUNCTIVAL FLAP LIMBAL STEM CELL TRANSPLANTATION PTERYGIUM EXCISION AND CONJUNCTIVAL AUTOGRAFT CONJUNCTIVAL AND CORNEAL TUMOR EXCISION CORNEAL PERFORATION SURGERY PERMANENT KERATOPROSTHESIS REFRACTIVE SURGERY Radial Keratotomy Excimer Laser Photorefractive Keratectomy Laser In Situ Keratomileusis CONCLUSION Anterior segment surgery ranges from routine cataract extraction and lens implantation, one of the most common surgical operations in the United States, to rarely performed surgery such as permanent keratoprosthesis. It also encompasses surgery first performed centuries ago, such as rudimentary pterygium excision, to the latest in keratorefractive surgery. CATARACT EXTRACTION AND INTRAOCULAR LENS IMPLANTATION The many reasons for the development of cataracts are discussed in detail in Chapter 8. Most cataracts are acquired, but they can also be congenital. This section focuses primarily on the treatment of acquired cataracts in adults. Cataracts in adults are generally age related, but some lens opacities may result from other causes such as trauma, inflammation, systemic illness such as diabetes, or medications such as corticosteroids. Cataracts generally advance slowly over years but can advance rapidly over months, or even faster in some patients. The primary indication for cataract extraction is diminished vision caused by the cataract, significantly affecting the patient's lifestyle. The exact point at which this hardship occurs depends on the patient. Certain patients require little visual function and may delay cataract surgery for years or indefinitely. Other patients with high visual needs seek cataract surgery with much smaller degrees of visual loss.