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ABSTRACT BOOK Department of Pharmaceutical Sciences (DISFARM) - University of Milan Milan, Ca’ Granda, July 16-19, 2019 XXVI National Meeting in Medicinal Chemistry XII Young Medicinal Chemists’ Symposium ABSTRACT BOOK Department of Pharmaceutical Sciences (DISFARM) - University of Milan The Department of Pharmaceutical Sciences (DISFARM) was created in 2012 from the Department of Pharmaceutical Sciences “Pietro Pratesi” and the section of Organic Chemistry "Alessandro Marchesini" of the Department of Molecular Sciences Applied to Biosystems. DISFARM is organized in the three sections of Medicinal Chemistry "Pietro Pratesi", Pharmaceutical Technology and Legislation "Maria Edvige Sangalli", and General and Organic Chemistry "Alessandro Marchesini", combining specific scientific skills, which favor the promotion and coordination of interdisciplinary research lines in the framework of pharmaceutical sciences. The goals are those of improving knowledge in the field of basic research, a major cultural investment to design a qualified research aimed at the discovery of novel drugs and able to boost an efficient technology transfer. The research at DISFARM covers a range of activities focused on the design, synthesis, development, and control of novel biologically active molecules, and of new pharmaceutical drug delivery systems, food supplements, cosmetics, biocides and medical devices. DISFARM’s scientific activities are financially supported by Italian and European grants, and are assisted by collaborations with public institutions and national/international companies. With the purpose of training young researchers, the Department hosts the PhD course in “Pharmaceutical Sciences” as well as the specialization school in “Hospital Pharmacy”, an interuniversity master and three post-graduate programs. The University of Milan The mission of the University of Milan, established in 1924, is to contribute to society through the pursuit of teaching/education and research at the highest international levels of excellence. It is the only Italian member among the 23 prestigious Universities of the League of European Research Universities (LERU). With a teaching staff of about 2,200 tenured professors and with almost 60,000 students, the University of Milan (UNIMI) is the largest university in Lombardy, one of the most dynamic and internationally-oriented EU regions. The University of Milan offers several study programmes covering three macro-disciplinary areas: i) Humanities, Social Sciences and Law, ii) Medicine and Healthcare, iii) Natural Sciences. The broad range of subjects taught, in the running 79 Undergraduate programmes, 57 Master programmes, 9 Single-cycle programmes, 21 Doctoral Schools, and several Advanced Vocational programmes, attracts students from all of Italy and the whole world. In addition to its excellent level of education, UNIMI has an established reputation as one of the institutions most strongly committed to basic and applied research in Europe. Research activities are conducted in 33 Departments and 22 Inter-departmental Research Centres, with more than 24,000 scientific publications in the last three years, 222 patent family and 24 active spin-off. 5 scientists from the University that have been ranked as highly cited by the ISI – Institute for Scientific Information (USA). The University’s researchers occupy leading positions in numerous research programmes conducted both at a national and international level. 4 technological platforms equipped with next-gen instrumentation are available for implementing research activities: COSPECT (spectroscopic, spectrometric and diffractometric analysis- spectroscopy), INDACO (computing power and data storage), NOLIMITS (imaging - light, confocal and electron microscopy) e OMICs (proteomic and metabolomics). In order to foster researcher participation to grant funding programmes, the University of Milan developed a Transition grant programme (5000€-80000€ per project) that supports proposers that applied to H2020 (over threshold, not funded) and ERC (evaluated A at step 1, not funded). The protection and exploitation of the scientific productivity is a strategic focus of the University of Milan. It has thus developed a policy to facilitate and shorten the time and mode of results transfer from research to market. In this view, it has also built relationships with different third parties such as industries, not profit organizations, institutional entities, SMEs. Several patent applications, in co-ownership with partners, havebeen filed to protect such results. The University of Milan is constantly developing projects in cooperation with some of the most relevant international research groups, often acting as activities coordinator. The interdisciplinary and intersectoral nature of such projects is enabled by the wide spectrum of basic and applied research activities present in University of Milan, spanning from Life, Physical and Social Sciences to Humanities. EU programmes represent a major source of funding for the University of Milan, which has signed 147 grants under the 7th Framework Programme (2007-2013), for a total value of € 50.344.153, and 120 grants up to April 2019 under the Horizon 2020 Programme, for a total value of more than € 30.000.000. Up to now, UMIL Researchers have been participating in around 40 COST Actions. UNIMI is actively promoting and supporting its internationality with English being the official language in the 31 PhD programmes, and the only language in one Bachelor programme and 10 Master and Single-cycle programmes. Other courses are partially held in English with 3 Masters of two years and one Single-cycle university programme of 5 years. UNIMI organizes 2 international Master programmes with courses held both in Milan, as well as in other countries, and with the possibility of obtaining a double degrees in two different countries of the consortium and 3 joint international PhD programmes organized in Milano together with other foreign Universities. Exchanges of students, scientists and professors with foreign universities are also encouraged and promoted by UNIMI that not only participates to several European and non-European exchange programmes (e.g. Erasmus+, LLP – Lifelong Learning Programme, Erasmus Mundus, Socrates, European Research Council, Business Exchange and Student Training, Fulbright, Galileo, Vinci and Vigoni programmes), but also have several specific international agreements with universities and research centers from all over the world. Finally grants for excellent researchers and students to specialize abroad are also funded by UNIMI. Società Chimica Italiana The Italian Chemical Society, founded in 1909 and established as a Moral Organization with Royal Decree no. 480/1926, is a scientific association with over three thousand five hundred members. The members carry out their activities in universities and research institutions, in schools, in industries, in public and private research and control laboratories, in the liberal profession. They are united not only by their interest in chemical science, but also by their desire to contribute to the cultural and economic growth of the national community, to the improvement of the quality of human life and to the protection of the environment. The Italian Chemical Society aims to promote the study and progress of chemistry and its applications, and in particular: • to encourage and increase scientific research in all fields of Chemistry; • to spread the knowledge of Chemistry and the importance of its applications in the context of the progress and well-being of humanity; • to promote and encourage the study of chemistry in universities and in all schools of all levels; • to promote in every field the development of the Sciences. To achieve these aims, and with the exclusion of profit, the Italian Chemical Society promotes, also through its Peripheral Organs, (Sections, Divisions, Interdivisional Groups), publications, studies, surveys, events. The Sections pursue the aims of the Society at a regional level. The Divisions bring together Members who follow a common scientific and research policy. The Interdivisional Groups bring together members interested in specific interdisciplinary topics. The governing bodies of the Society are the President, the Executive Committee and the Central Council. Sections and Divisions are also governed by a President and a Board of Directors. The Society organises numerous conferences, courses, schools and seminars both at national and international level. To spread the principles of chemical science in the upper secondary school organizes annually the Chemistry Games, a competition that allows young people to test their knowledge in this field and that selects the national team for the International Chemistry Olympics. Important is the publishing activity with the publication, together with other European Chemical Societies, of scientific journals of high international level. It also publishes the journal La Chimica nella Scuola. The official organ of the Society is the journal La Chimica e l'Industria. EFMC - European Federation for Medicinal Chemistry The European Federation for Medicinal Chemistry (EFMC) is an independent association founded in 1970 that represents 25 scientific organisations from 23 European countries. Its objective is to advance the science of medicinal chemistry & chemical biology by promoting cooperation and encouraging strong links between the national adhering organisations in order to deepen contacts and exchanges between medicinal chemists & chemical biologists in Europe and around the World.
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