DOCSLIB.ORG

Surgi(~Al Management of Intracranial Gliomas*

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Surgi(~Al Management of Intracranial Gliomas* SURGI(~AL MANAGEMENT OF INTRACRANIAL GLIOMAS* A. LEY, M.D., A. LEY, Ji~., M.D., J. M. GUITART, M.D., AND C. OLIVERAS, M.D. Neurosurgical Service, University of Barcelona Medical School, Barcelona, Spain (Received for publication October 19, 1961) EREBRAL gliomas have challenged the TABLE 1 ingenuity and skill of surgeons ever Intracranial tumors C since the beginning of neurological 1940-1960 surgery. While technical progress during the Type No. Per Cent past ~0 years has brought about satisfactory solutions fl)r the surgical management of 1. Gliomas 48"2 40.9 other intracranial tumors, as for instance `2. Sarcomas `27 `2.3 3. Blood-vessel tumors 61 5.`2 acoustic neurinomas, angiomas and eranio- 4. Papillomas (ehoroid plexus) 7 0.6 pharyngiomas, formerly considered impossi- 5. Congenital tumors 48 4.1 ble to treat radically, therapeutic progress in 6. Meningiomas 145 1`2.3 7. Neurinomas 69 5.9 the surgical management of gliomas has been 8. Pituitary adenomas 88 7.5 practically nil. 9. M:ctastatic tumors 116 9.8 In order to evaluate how much we had ac- 10. Granulomas 51 4.3 11. Parasitic cysts 34, `2.9 complished in that field, we made a survey of 1`2. Miscellaneous 50 4.3 all the intracranial tumors seen at the senior writer's service during the past ~1 years Total 1,178 1O0 (1940-1960). gliomas following the classification of Bailey INCIDENCE and Cushing. 5 We are well aware of the in- Of 1,178 verified intracranial expanding consistency of any classification of tumors lesions (Table 1), 48~ (40.9 per cent) were based on morphology, and we know by our classified as gliomas. This proportion is very own experience the difficulties involved in close to the 4~.3 per cent in Cushing's ~ 193~ classifying some of these tumors on that series of ~,0r intraeranial tumors, but basis. However, if we do not take too slightly lower than those reported by Adson literally the histogenetic implications in- and Svien 1 (47 per cent), Olivecrona is (47.9 per cent), Grant 11 (48.5 per eent),Davisl~ TABLE per cent), Bailey 3 (59.1 per cent) and Row- Cerebral gliomas botham et al. 2~ (66.5 per cent). However, if 19]~0-1960 we take into account that a large proportion of the lesions listed in the miscellaneous Histological Variety No. Per Cent group in Table 1 were tumors of the brain Astrocytoma 84 17.5 stem (35 cases) and 3rd ventricle (11 eases), Cerebral 87 which though not verified histologically, Cerebellar 47 probably were gliomas in the majority of Ependymal tumors 44 9.1 Oligodendroglioma 41 8.5 these cases, the real proportion of that type Pinealoma 6 1. `2 of tumor in our series would rise to over 44 Spongioblastoma polare `24 5.0 per cent. Medulloblastoma S1 (4.4 Glioblastoma `246 51.0 Table 2 shows the distribution of our Ganglioneuroma `2 0.5 Neuroepithelioma 4 0.8 * Read at the Second International Congress of Neurological Surgery, Washington, D. C., October 17, Total 48`2 100 1961. 365 366 A. LEY, A. LEY, JR., J. M. GUITART AND C. OLIVERAS volved, we think, as do Zimmerman 23 and tively low, and also because we may have Ziilch 24 that Bailey and Cushing's classifica- had different criteria of differentiation be- tion still is the most useful and satisfactory tween this type of tumor and primary sar- we have at hand. Besides, in reviewing our coma. 4,s,I5 This would also explain the slight material, we have been able to confirm once difference found in the incidence of cerebellar more that not only does it serve a noso- astrocytomas. The larger incidence of oligo- graphic urge but also that it corresponds to a dendrogliomas in our series (s may be well established biological fact, the different attributable to the fact that our series began varieties possessing well defined topographic, in 1940 and that we may therefore have been clinical and evolutional peculiarities. more conscious of their existence. In fact, as If we compare the incidence of the various far back as 1932 Cushing 9 was already aware types of gliomas in our series with that in the of the possibility that some of the 18 cases larger series of Cushing 9 and of Grant, n all (2.6 per cent) of cerebral medulloblastomas based on the same pathological principles, in his series could have been oligodendroglio- we find some striking differences (Table 3). nlas. The main ones are the lower proportion of The incidence of ependymal tumors in our cerebral astrocytomas and the higher per- series was also two-fold compared with the centage of glioblastomas in our series, the others. We do not know of any explanation difference being roughly 20 per cent less and for that fact. 20 per cent plus, respectively. We think the explanation may lie in the pathological cri- HISTOLOGY AND LOCATION teria that guide our classification and proves In order to evaluate the surgical results, a the difficulty stressed by Kernohan 13 and subdivision of each of the histological varie- others as to the differentiation between glio- ties was established, on the bases of the de- blastomas and some malignant forms of gree of differentiation, cellular atypias or astrocytomas. The proportions found by monstrosities, number of mitoses, and so Ztilch u are so different that they cannot be forth. compared with the above-mentioned series. Of the cerebral astrocytomas, 18 were Concerning cerebellar medulloblastomas, what may be considered pure types, the the difference is not so great. This may be majority being of the fibrillary variety; only ascribable partly to the fact that the propor- were cystic. Four showed areas of oligo- tion of infantile cases in our series is rela- dendroglial or ependymal differentiation, and 15 had signs of dedifferentiation or ma- TABLE 3 lignancy. Among them, there were 5 with the Percentage of various types of gliomas characteristics of astroblastoma: 1 cystic and rather malignant. Cushing9 Grant n Present Histological (86~ (1,147 Series In the group of ependymal tumors, ~8 Variety cases) cases) (48~eases) were ependymomas. Two of them showed astrocytic and 1 spongioblastic differentia- Astrocytoma Cerebral ~6.6 ~4.8 6.8* tion. Only 1 was cystic and presented in- Cerebellar 10.5 14.4 9.7 tensive calcification. There were 15 epen- Glioblastoma 80.0 80.5 51.0 dymoblastomas, 6 of them being cystic. Medulloblastoma (cerebellar) 9.8 9.7 6. There was also a very atypical and undiffer- Ependymoma 8.0 4.7 9.1 entiated ependymal tumor that originated in Oligodendroglioma 8.9 4.1 8.5 the septum pellucidum. As far as their loca- Astroblastoma 4.0 5.4 l. 0 Spongioblastoma 4.6 3.0 5.0 tion is concerned, 24 were supratentorial, Pinealoma 1.6 1.1 1. most of them (17 cases) arising from the walls of the lateral and 8rd ventricle and sep- * Five astroblastomas, which were included with the cerebral astrocytomas in Table ~, have been omitted turn pellucidum. Nineteen were subten- here. torial; of these, 11 developed in the 4th ven- .
Load more

Recommended publications
  • Pineal Region Tumors: Computed Tomographic-Pathologic Spectrum
    415 Pineal Region Tumors: Computed Tomographic-Pathologic Spectrum Nancy N. Futrell' While several computed tomographic (CT) studies of posterior third ventricular Anne G. Osborn' neoplasms have included descriptions of pineal tumors, few reports have concentrated Bruce D. Cheson 2 on these uncommon lesions. Some authors have asserted that the CT appearance of many pineal tumors is virtually pathognomonic. A series of nine biopsy-proved pineal gland and eight other presumed tumors is presented that illustrates their remarkable heterogeneity in both histopathologic and CT appearance. These tumors included germinomas, teratocarcinomas, hamartomas, and other varieties. They had variable margination, attenuation, calcification, and suprasellar extension. Germinomas have the best response to radiation therapy. Biopsy of pineal region tumors is now feasible and is recommended for treatment planning. Tumors of the pineal region account for less th an 2% of all intracrani al neoplasms [1]. While several reports of computed tomography (CT) of third ventricular neoplasms have in cluded an occasi onal pineal tumor [2 , 3], few have focused on the radiographic spectrum of th ese uncommon lesions [4]. Some authors have asserted that the CT appearance of many pineal tumors is virtuall y pathognomonic [5]. We studied a series of nine biopsy-proven pineal gland tumors that demonstrated remarkable heterogeneity in both histopath ologic and CT appearance. Materials and Methods A total of 17 pineal gland tumors were detected in 15,000 consecutive CT scans. Four patients were female and 13 were male. Mean age for the fe males was 27 years; for the males, 15 years. Initial symptoms ranged from headache, nausea, and vomiting, to Parinaud syndrome, vi sual field defects, diabetes insipidus, and hypopituitari sm (table 1).
    [Show full text]
  • Germinoma of the Pineal Its Identity with Gcrminoma ( Scminoma") of the Testis
    Germinoma of the Pineal Its Identity with Gcrminoma ( Scminoma") of the Testis Major Nathan B. Friedman, MC, AUS (From the Army Institute ot Pathology, \X/ashillgto~L D. C.) (Received for publication December 10, 1946) In 1944 Dorothy Russell (15) published the re- gcrminonmtous elements. Only 2 tulnors in this suits of a study of pineal tumors. She presented a group of 8 appeared to bc of neural origin; one, rational explanation for the well known similarity which had the pattern of a classic pinealoma, was in histologic appearance of "pinealomas" and "semi- TABLE l: DATA IN T\VENTY-THREt CASES OF PlNEAL nomas." She suggested that in'any "pincalomas" NEOPI.ASM ucre in truth teratoid tumors. The present report Case Age, Type of proposes to confirln h er.~obscrvations and to extend No. Sex years npoplasm s features her interpretations in accord with the teratologic CRovP 1 concepts gained through study of nearly 1,000 tu- 1 M 29 Neural mors of the testis at the Army Institute of Patho- 2 XI 22 Germinoma Extrapineal. Pitui- logy (6). tary involved. Dia- The files of the Institute contain pathologic ma- betes insipidus. Hypogonadism. terial from 23 patients with tumors of the pineal or ectopic "pinealomas." Fifteen tumors were submit- 3 1~i 17 Neural ted by military installations ~ (Group 1), and 8 were 4 1~I 18 Germinoma Pituitary involved. obtained from civilian sources e (Group 2). The Diabetes insipidus. _~I 21 essential data in all 23 cases arc listed in Table I. Puhnonary metas- tases. Radiosensi- Seven of the 15 tumors in group 1 were identical tMty.
    [Show full text]
  • Points of Consideration in Diagnosis of Brain Tumors
    University of Nebraska Medical Center DigitalCommons@UNMC MD Theses Special Collections 5-1-1934 Points of consideration in diagnosis of brain tumors Robert J. Stein University of Nebraska Medical Center This manuscript is historical in nature and may not reflect current medical research and practice. Search PubMed for current research. Follow this and additional works at: https://digitalcommons.unmc.edu/mdtheses Part of the Medical Education Commons Recommended Citation Stein, Robert J., "Points of consideration in diagnosis of brain tumors" (1934). MD Theses. 356. https://digitalcommons.unmc.edu/mdtheses/356 This Thesis is brought to you for free and open access by the Special Collections at DigitalCommons@UNMC. It has been accepted for inclusion in MD Theses by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. POINTS OF CONSIDERATION IN DIAGNOSIS OF BRAIN TUMORS by Robert J. Stein University of Nebraska College of Medicine Omaha Page I. Introduction ••.••••••••••.••.••••••••••••••••••••••• 1. II. Histogenes is of the Brain ••••••••••••.•••••••••••••• I. III.Classification of Intracranial Tumors............ 11. IV. Outllne of Methods of Examination ••••••••••••••••••• 31. V. General Symutoms and Signs of Increased Intra- cran~al Pressure ••. ••• .••••••••••••••••••••• • • • :J •••• 36. VI. Focal Signs and Symptoms of Brain Tumor ••••••••••••• 45. Cerebral Tumors ••••••••••, •••••••••••••••••••••••••• 47. Tumors of Cerebellum, Pons and Medulla ••••••••••• •• 57. Tumors of the Pi tui tary Body ••••••••••••••••.•••• .'. 61. VI I. Summary. • • • • • • . • • • • • . • • • • • . • • • . • • • • • • • • . • . • • • • • • • •• 65. Bibliogranhy •••••••••••••••••••••••••• • • • • • • • • • • • • • 69. 1. I. INTRODUCTION The progress of the surgery of intracranial tumors has been asso ciated intimately wi th the advenae­ ment of asepsis and surgical technique in genera.l i methods of more accurate diagnosis and a correlation of the pathology of tumors encountered with the clini­ cal course of the patient.
    [Show full text]
  • A Glioma in a Dog and a Pinealoma in a Silver Fox (Vulpes Fulvus)
    A GLIOMA IN A DOG AND A PINEALOMA IN A SILVER FOX (VULPES FULVUS) CARL F. SCHLOTTHAUER, D.V.M., Division of E.aperinienta1 Medicine, The Mauo Foundation JAMES W. KERNOHAN, M.D., Section on Pathologic Anatomy, The Mayo Clinic, Rochester, Minnesota Only a small number of primary intracranial neoplasms have been observed in mammals and birds. Either they do not occur as fre- quently in lower animals as they do in man or they are overlooked. The latter is a probable explanation, as only a small number of animals that die of natural causes come to necropsy and because of the dif- ficulty of opening the cranium with inadequate equipment this part of the examination generally is omitted. Slye, Holmes and Wells, in 1931, reviewed the literature 011 intrn- cranial and cord tumors of lower animals and found only 36 cases re- ported. Twenty-six of these were intracraiiial tumors, 11 of which were in the hypophysis. They at that time reported 4 new cases of primary intracranial neoplasms, 3 occurring in mice of the Slye stock and one in a green parrakeet (Agatomis puEZuriu). The neoplasms found in tlie mice were : an endothelioma of a cerebral peduncle, a papil- lomatous growth in the ependyma of the lateral ventricle, and an in- filtrating adenoma of the hypophysis. The tumor observed in the parrakeet was an adeiioma in tlie hypophysis. Iii their summary thew writers mention that it is especially noteworthy that only one seemingly conclusive report of a cerebral glioma in an animal could be found. Dawes, in 1930, reported two intracrunial neoplasms in dogs.
    [Show full text]
  • New Jersey State Cancer Registry List of Reportable Diseases and Conditions Effective Date March 10, 2011; Revised March 2019
    New Jersey State Cancer Registry List of reportable diseases and conditions Effective date March 10, 2011; Revised March 2019 General Rules for Reportability (a) If a diagnosis includes any of the following words, every New Jersey health care facility, physician, dentist, other health care provider or independent clinical laboratory shall report the case to the Department in accordance with the provisions of N.J.A.C. 8:57A. Cancer; Carcinoma; Adenocarcinoma; Carcinoid tumor; Leukemia; Lymphoma; Malignant; and/or Sarcoma (b) Every New Jersey health care facility, physician, dentist, other health care provider or independent clinical laboratory shall report any case having a diagnosis listed at (g) below and which contains any of the following terms in the final diagnosis to the Department in accordance with the provisions of N.J.A.C. 8:57A. Apparent(ly); Appears; Compatible/Compatible with; Consistent with; Favors; Malignant appearing; Most likely; Presumed; Probable; Suspect(ed); Suspicious (for); and/or Typical (of) (c) Basal cell carcinomas and squamous cell carcinomas of the skin are NOT reportable, except when they are diagnosed in the labia, clitoris, vulva, prepuce, penis or scrotum. (d) Carcinoma in situ of the cervix and/or cervical squamous intraepithelial neoplasia III (CIN III) are NOT reportable. (e) Insofar as soft tissue tumors can arise in almost any body site, the primary site of the soft tissue tumor shall also be examined for any questionable neoplasm. NJSCR REPORTABILITY LIST – 2019 1 (f) If any uncertainty regarding the reporting of a particular case exists, the health care facility, physician, dentist, other health care provider or independent clinical laboratory shall contact the Department for guidance at (609) 633‐0500 or view information on the following website http://www.nj.gov/health/ces/njscr.shtml.
    [Show full text]
  • Presenting Psychiatric and Neurological Symptoms and Signs of Brain Tumors Before Diagnosis: a Systematic Review
    Review Presenting Psychiatric and Neurological Symptoms and Signs of Brain Tumors before Diagnosis: A Systematic Review Fatima Ghandour 1,2, Alessio Squassina 1, Racha Karaky 3, Mona Diab-Assaf 2, Paola Fadda 1,4,5,6,* and Claudia Pisanu 1 1 Department of Biomedical Sciences, Division of Neuroscience and Clinical pharmacology, University of Ca- gliari, 09042 Monserrato, Italy; [email protected] (F.G.); [email protected] (A.S.); [email protected] (C.P.) 2 EDST, Pharmacology and Cancerology Laboratory, Faculty of Sciences, Lebanese University, Beirut 1500, Lebanon; [email protected] 3 Drug-Related Sciences department, Faculty of Pharmacy, Lebanese University, Hadath 1500, Lebanon; [email protected] 4 Centre of Excellence "Neurobiology of Addiction", University of Cagliari, 09042 Monserrato, Italy 5 CNR Institute of Neuroscience - Cagliari, National Research Council, 09042 Monserrato, Italy 6 National Institute of Neuroscience (INN), 10126 Turin, Italy * Correspondence: [email protected] Table S1. Characteristics of “pediatric group” case reports (age < 18 years) with initial psychiatric symptoms with or without generalized and/or neurological signs and symptoms. Ref. Age Gender Tumor type Tumor location Psychiatric symptoms (P.S) Neurological symptoms Time from P.S after symptoms to tumor treat- diagnosis ment [1] 5 F Diffuse intrinsic Pontine Personality changes Motor deficits 3 weeks N.S. pontine glioma [2] 3 M Pilocytic Astrocyto- Rostral medulla Paroxysmal crying, anxiety Nausea, vomiting, seizure 8 months ✓
    [Show full text]
  • A Typical Neurofibromatosis Type 1 in Adult with Intracranial T2 Hyperintensities and Pinealoma: a Case Report
    vv ISSN: 2455-5282 DOI: https://dx.doi.org/10.17352/gjmccr CLINICAL GROUP Received: 16 April, 2020 Case Report Accepted: 25 April, 2020 Published: 27 April, 2020 *Corresponding author: Yongan Sun, Associate A typical neurofi bromatosis Professor, Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District 100034, Beijing, China, Tel: +86 133 91705678; type 1 in adult with E-mail: ORCID: https://orcid.org/0000-0001-9119-5322 intracranial T2 Keywords: Neurofi bromatosis; T2 hyperintensities; Pinealoma; High-grade glioma; Clinical manifestation hyperintensities and https://www.peertechz.com pinealoma: A Case Report Siwei Chen, Haiqiang Jin, Jing Bai, Wei Zhang, Jingjing Luo, Yining Huang and Yongan Sun* Associate Professor, Department of Neurology, Peking University First Hospital, China Abstract Neurofi bromatosis type 1 (NF-1) is a common autosomal dominant inherited disorder. Aside from typical symptoms like pigmentary manifestation, patients with NF-1 can also have unspecifi ed T2 hyperintensities (T2Hs) on the brain and may develop benign or malignant tumours in central nervous system or other parts of the body. In this article, we reported a 54-year-old female diagnosed as NF-1 combined with T2Hs and pinealoma that was proved to be a high-grade glioma in later follow-up. We noticed some clinical manifestations such as pigmented teeth and dentition defects that had not been described before. There were some refl ections from the poor prognosis of this patient. Even though the course of the disease is relatively indolent most of the time, long-term surveillance is in need and treatment may be required in those with symptoms or unstable imaging fi ndings.
    [Show full text]
  • Differential Diagnosis of Sellar Masses
    ~~ ~~ ~ ADVANCES IN PITUITARY TUMOR THERAPY 0889-8529/99 $8.00 + .OO DIFFERENTIAL DIAGNOSIS OF SELLAR MASSES Pamela U. Freda, MD, and Kalmon D. Post, MD Pituitary adenomas are the most common cause of a mass in the sella. In as many as 9% of cases, other etiologies are responsible for mass lesions in the sellar regions4,13' (Table 1). The differential diagnosis of nonpituitary sellar masses is broad and includes cell rest tumors, germ cell tumors, gliomas, menin- giomas, metastatic tumors, vascular lesions, and granulomatous, infectious, and inflammatory processes (Table 2). Differentiating among these potential etiolo- gies may not always be straightforward because many of these lesions, tumorous and nontumorous, may mimic the clinical, endocrinologic, and radiographic presentations of pituitary adenomas. In some cases, there are no features that clearly distinguish the unusual etiologies from the clinically nonfunctioning pituitary adenoma. In others, certain endocrine, neurologic, and radiographic findings that are more characteristic of patients with a nonpituitary sellar mass may be present and can help in their differentiation. Correct preoperative diag- nosis is clinically important because the treatment of choice for many of these nonpituitary sellar masses differs from that of a pituitary tumor. This article provides an overview of the clinical and radiographic characteristics of both pituitary tumors and the nonpituitary lesions found in the sellar/parasellar region and discusses in detail the specific nonpituitary etiologies of the sellar mass. SIGNS AND SYMPTOMS OF PITUITARY TUMORS Pituitary tumors vary in presentation. Clinical findings depend largely on whether the tumor is hormone secreting or clinically nonfunctioning, on the size and pattern of tumor growth, and on whether normal pituitary gland function is disrupted.
    [Show full text]
  • Mental and Seizure Manifestations in Relation to Brain Tumors a Statistical Study
    166 EPlLEPSlA Mental and Seizure Manifestations in Relation to Brain Tumors A Statistical Study A. GUVENER, B. K. BAGCHI, K. A. KO01 AND H. D. CALHOUN The Electroencephalographic Laboratory, Neuropsychiatric Institute, University of Michigan Medical Center, Ann Arbor, Mich. (U.S.A.) INTRODUCTION It is well known that mental or behavioral changes and seizures occur in some phases of the development of many tumors. Many investigators in reporting large series (300 or over) have given the frequency of the clinical manifestations and their relation- ships to areas and types of tumors (2, 4, 5, 9, 10, 12-15, 17, 20, 22, 24, 27, 31). It is not always clear why some tumors produce the above mentioned manifestations and others of Lhe same type, same location and about the same size do not. We thought it might be of interest to make a statistical evaluation of the interrelationships between three variables, tumor location, tumor type, increased intracranial pressure in respect to mental and seizure manifestations. In the literature these relationships are not always clearly given. These might have some bearing on the mechanism of the clinical changes. MATERIAL AND METHODS Out of 901 brain tumor entries in the EEG Laboratory file with EEG and clinical data only 326 have been selected for this report. The excluded ones are the following: all 359 brain tumor entries before 1950, in addition to a total of 167 metastatic, brain stem and posterior fossa tumors, and 49 tumors with incomplete clinical and EEG information. Out of the accepted 326 cases gross and microscopic autopsy findings were available in 62.
    [Show full text]
  • NYS Cancer Registry Facility Reporting Manual
    The New York State CANCER REGISTRY Facility Reporting Manual 2021 - EDITION THE NEW YORK STATE DEPARTMENT OF HEALTH STATE OF NEW YORK KATHY HOCHUL, GOVERNOR DEPARTMENT OF HEALTH HOWARD A. ZUCKER, M.D., J.D., COMMISSIONER The NYSCR Reporting Manual Revised September 2021 New York State Cancer Registry Reporting Manual Table of Contents ACKNOWLEDGEMENT PART ONE – OVERVIEW PART TWO – CONFIDENTIALITY PART THREE - REPORTABLE CONDITIONS AND TERMINOLOGY PART FOUR - DATA ITEMS AND DESCRIPTIONS PART FIVE - CASEFINDING PART SIX - DEATH CERTIFICATE ONLY AND DEATH CLEARANCE LISTS PART SEVEN – QUALITY ASSURANCE PART EIGHT – ELECTRONIC REPORTING APPENDIX A - NYS PUBLIC HEALTH LAW APPENDIX B – HIPAA INFORMATION The NYSCR Reporting Manual – Table of Contents Revised September 2021 Page Left Blank Intentionally The NYSCR Reporting Manual Revised September 2021 ACKNOWLEDGEMENT We wish to acknowledge the Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries (NPCR) and the National Cancer Institute’s (NCI) Surveillance Epidemiology and End Results program (SEER) for their support. Production of this Reporting Manual was supported in part by a cooperative agreement awarded to the New York State Department of Health by the NPCR and a contract with SEER. Its contents are solely the responsibility of the New York State Department of Health and do not necessarily represent the official views of the CDC or NCI. The NYSCR Reporting Manual - Acknowledgement Revised September 2021 Page Left Blank Intentionally The NYSCR Reporting Manual Revised September 2021 New York State Cancer Registry Reporting Manual Part One – Overview 1.1 WHAT IS THE NEW YORK STATE CANCER REGISTRY? .................................... 1 1.2 WHY REPORT TO THE NYSCR? ..........................................................................
    [Show full text]
  • 11E. SNC Tumours 1
    Brain tumours General features Tentatively classified according to embryogenesis “Blastic” and “Cystic” refer to specific morphological features Embryonal tumours reproduce specific maturative stages of neural cells Grading as a correspondence of morphology with clinical course Several types arise at specific sites (topographic correlations) New entities frequently added (based on IHC and molecular studies) Mesenchymal tumours increase Primary non-Hodgkin Lymphomas increase (HIV) PRIMARY CNS TUMOURS 10% of all primary tumours 10/100.000 subjects/yr. Adulthood to elderly people 10% in pediatric age (3-5% before 5 ys.) Prognostic criteria Histopathology: • Histotype • Grading Clinical data • Age & site • Imaging • Performance Status (Karnowski index) • Slowly growing • Local invasion • Liquoral diffusion • Rare extra-cranial metastases Exceptions: Medulloblastoma, Glioblastoma Symptoms: Space occupying lesion (SOL) • Endocranic hypertension • Headache • Vomiting • Papillary oedema Neural irritation Seizures Neurological deficit (sensory or motor) Symptoms related to: Tumour size Tumour site Midline Medulloblastoma (cerebellar worm) Spongioblastoma (brain and cerebellum) Lateral ventricles Papilloma, ependymoma Pineal and 3rd ventricle Pinealoma Ponto-cerebellar angle Neurinoma (acoustic nerve) Tumor type and age Infancy and childhood • Medulloblastoma • Pinealoblastoma • Spongioblastoma Teenage and young adulthood • Ependimoma • Papilloma • Astrocitoma Adulthood and elderly • Oligodendroglioma • Glioblastoma • Neurinoma Primary brain tumours
    [Show full text]
  • Brain Lesions and Eating Disorders R Uher, J Treasure
    852 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.2004.048819 on 16 May 2005. Downloaded from PAPER Brain lesions and eating disorders R Uher, J Treasure ............................................................................................................................... See end of article for J Neurol Neurosurg Psychiatry 2005;76:852–857. doi: 10.1136/jnnp.2004.048819 authors’ affiliations ....................... Correspondence to: Rudolf Uher, PO59 Eating Objective: To evaluate the relation between lesions of various brain structures and the development of Disorders Unit, Institute of eating disorders and thus inform the neurobiological research on the aetiology of these mental illnesses. Psychiatry, King’s College Method: We systematically reviewed 54 previously published case reports of eating disorders with brain London, De Crespigny damage. Lesion location, presence of typical psychopathology, and evidence suggestive of causal Park, London, SE5 8AF, UK; [email protected] association were recorded. Results: Although simple changes in appetite and eating behaviour occur with hypothalamic and brain Received 29 June 2004 stem lesions, more complex syndromes, including characteristic psychopathology of eating disorders, are Revised version received associated with right frontal and temporal lobe damage. 30 August 2004 Accepted Conclusions: These findings challenge the traditional view that eating disorders are linked to hypothalamic 17 September 2004 disturbance and suggest a major role of frontotemporal circuits with right hemispheric predominance in ....................... the pathogenesis. ating disorders, including anorexia and bulimia nervosa, into four categories: ‘‘anorexia nervosa’’ (underweight and are characterised by abnormal eating behaviour and either food or body related preoccupations or rituals, purging, Etypical psychopathological features, including fear of or hyperactivity), ‘‘atypical anorexia’’ (underweight without fatness, drive for thinness, and body image disturbance.
    [Show full text]