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Curriculum Vitae CURRICULUM VITAE Name: Roderick MacKinnon Address: Laboratory of Molecular Neurobiology and Biophysics HHMI/The Rockefeller University P.O. Box 47 1230 York Avenue New York, NY 10021 Date of Birth: February 19, 1956 Place of Birth: Melrose, Massachusetts Education: 1978 B.A. Brandeis University (Biochemistry) 1982 M.D. Tufts University School of Medicine Postdoctoral Training: 1985-86 NIH Postdoctoral Fellow, Department of Medicine, Beth Israel Hospital, Harvard University, Boston, MA 1986-89 NIH Postdoctoral, Department of Biochemistry, Brandeis University, Waltham, MA Academic and Hospital Appointments: 1982-85 Medical House Officer, Internal Medicine, Beth Israel Hospital/Harvard Medical School, Boston, MA 1989-91 Assistant Professor, Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA 1991-92 Assistant Professor, Department of Neurobiology, Harvard Medical School, Boston, MA 1992-95 Associate Professor, Department of Neurobiology, Harvard Medical School, Boston, MA 1995-96 Professor, Department of Neurobiology, Harvard Medical School, Boston, MA 1996-present Professor, Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 1997-present Investigator, Howard Hughes Medical Institute. Awards and Honors: 1978 High Honors in Biochemistry, Brandeis University 1982 Alpha Omega Alpha Medical Honors Society, Tufts University School of Medicine 1992 PEW Scholar in the Biomedical Sciences 1992 McKnight Scholars Award 1995 Biophysical Society Young Investigator Award 1997 McKnight Investigator Award 1998 W. Alden Spencer Award, Columbia University 1998 AAAS Newcomb Cleveland Prize 1999 Albert Lasker Basic Medical Research Award 2000 Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research 2000 Hodgkin-Huxley-Katz Prize 2000 Alexander M. Cruickshank Award 2000 Membership to the U.S. National Academy of Sciences 2001 Gairdner Foundation International Award 2001 Perl-UNC Neuroscience Prize 2002 The Degree of Doctor of Science, Honoris Causa – Tufts University 2003 Fritz Lipmann Lectureship Award 2003 Nobel Prize in Chemistry 2003 Louisa Gross Horwitz Prize 2003 Scientific American Research Leader of the Year 2004 Max Tishler Prize – Harvard University 2004 National Lecturer, Biophysical Society Annual Meeting 2004 Bijvoet Medal for Outstanding Research – The Netherlands 2005 The Hans Neurath Award-Protein Society 2005 The Degree of Doctor of Science, Honoris Causa – Brandeis University 2005 Membership to the American Philosophical Society 2006 Rolf Sammet Honorary Lectureship –J.W. Goethe University, Frankfurt, Germany 2006 The Degree of Doctor of Science, Honoris Causa – Pohang University Of Science and Technology, Korea BIBLIOGRAPHY 1) MacKinnon R, Morgan JP (1986) Influence of the thyroid state on the calcium transient in ventricular muscle. Pflugers Arch. 407: 142-144 2) MacKinnon R, Gwathmey J, Morgan JP (1987) Differential effects of reoxygenation on intracellular calcium and isometric tension. Pflugers Arch. 409: 448-453 3) MacKinnon R, Gwathmey J, Allen P, Briggs M, Morgan JP (1988) Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. Circ. Res. 63: 1080-1089. 4) Anderson CS, MacKinnon R, Smither C, Miller C (1988) Charybdotoxin block of single Ca2+- activated K+ channels: Effects of channel gating, voltage, and ionic strength. J. Gen. Physiol. 91: 317-333 5) MacKinnon R, Miller C (1988) Mechanism of charybdotoxin block of the high-conductance Ca2+-activated K+ channel. J. Gen. Physiol. 91: 335-349 6) MacKinnon R, Reinhart P, White M (1988) Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features. Neuron 1: 997-1001 7) MacKinnon R, Miller C (1989) Functional modification of Ca2+-activated K+ channel by trimethyloxonium. Biochemistry 28: 8087-8092 8) MacKinnon R, Latorre R, Miller C (1989) The role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry 28: 8092-8099 9) MacKinnon R, Miller C (1989) Mutant K+ channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science 245: 1382-1385 10) Schumaker M, MacKinnon R (1990) A simple model for multi-ion permeation: single- vacancy conduction in a simple pore model. Biophysical J. 58: 975-984 11) MacKinnon R, Heginbotham L, Abramson T (1990) Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron 5: 767-771 12) MacKinnon R, Yellen G (1990) Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science 250: 276-279 13) Yellen G, Jurman M, Abramson T, MacKinnon R (1991) Mutations affecting TEA blockade identify the probable pore-forming region of a K+ channel. Science 251: 939-942 14) MacKinnon R (1991) Determination of the subunit stoichiometry of a voltage-dependent potassium channel. Nature 350: 232-235 15) Heginbotham L, MacKinnon R (1992) The aromatic binding site for tetraethylammonium on potassium channels. Neuron 8: 483-491 16) Heginbotham L, Abramson T, MacKinnon R (1992) A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science 258: 1152-1155 17) Escobar L, Root M, MacKinnon R (1993) Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor. Biochemistry 32: 6982-6987 18) Perozo E, MacKinnon R, Bezanilla F, Stefani E (1993) Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron 11: 353-358 19) Root M, MacKinnon R (1993) Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron 11: 459-466 20) Heginbotham L, MacKinnon R (1993) Conduction properties of the cloned Shaker K+ channel. Biophysical J. 65: 2089-2096 21) MacKinnon R, Aldrich RW, Lee AW (1993) Functional stoichiometry of Shaker potassium channel inactivation. Science 262: 757-759 22) Heginbotham L, Lu Z, Abramson T, MacKinnon R (1994) Mutations in the K+ channel signature sequence. Biophysical J. 66: 1061-1067 23) Garcia ML, Garcia-Calvo M, Hidalgo P, Lee A, MacKinnon R (1994) Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus Quin questriatus var. Hebraeus venom. Biochemistry 33: 6834-6839 24) Lu Z, MacKinnon R (1994) A conductance maximum observed in an inward-rectifier potassium channel. J. Gen. Physiol. 104: 477-486 25) Root MJ, MacKinnon R (1994) Two identical noninteracting sites in an ion channel revealed by proton transfer. Science 265: 1852-1856 26) Lu Z, MacKinnon R (1994) Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature 371: 243-246 27) Gross A, Abramson T, MacKinnon R (1994) Transfer of toxin receptor to an insensitive potassium channel. Neuron 13: 961-966 28) Hidalgo P, MacKinnon R (1995) Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science 268: 307-310 29) Krezel A, Khasibhatla C, Hidalgo P, MacKinnon R, Wagner G (1995) Solution structure of the K+ channel inhibitor agitoxin 2: Caliper for probing channel geometry. Protein Science 4: 1478-1489 30) Swartz K, MacKinnon R (1995) An Inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15: 941-949 31) Lu Z, MacKinnon R (1995) Probing a potassium channel pore with an engineered protonatable site. Biochemistry 34: 13133-13138 32) Park C-S, MacKinnon R (1995) Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry 34: 13328-13333 33) Ranganathan R, Lewis J, MacKinnon R (1996) Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron 16: 131-139 34) Gross A, MacKinnon R (1996) Agitoxin footprinting the Shaker potassium channel pore. Neuron 16: 399-406 35) Aggarwal SK, MacKinnon R (1996) Contribution of the S4 segment to gating charge in the Shaker potassium channel. Neuron 16: 1169-1177 36) Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85: 1067-1076 37) Swartz KJ, MacKinnon R (1997) Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron 18: 665-673 38) Swartz KJ, MacKinnon R (1997) Mapping the receptor site for Hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron 18: 675-682 39) Lu Z, MacKinnon R (1997) Purification, characterization, and synthesis of an inward- rectifier K+ channel inhibitor from scorpion venom. Biochemistry 36: 6936-6940 40) Doyle DA, Cabral JM, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280: 69-77 41) MacKinnon R, Cohen SL, Kuo A, Lee A, Chait BT (1998) Structural conservation in prokaryotic and eukaryotic potassium channels. Science 280: 106-109 42) Imredy J, Chen C, MacKinnon R (1998) A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry 37: 14867-14874 43) Cabral JMH, Lee A, Cohen SL, Chait BT, Li M, MacKinnon R (1998) Crystal structure and functional analysis of the HERG K+ channel N-terminus: a eukaryotic PAS domain. Cell 95: 649-655 44) Gulbis JM, Mann S, MacKinnon R (1999) Structure of a voltage-dependent K+ channel subunit. Cell 97: 943-952 45) Roux B, MacKinnon R (1999)
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