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What's New in Lymphoma?

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What's New in Lymphoma? Saturday 17 November What’s new in lymphoma? Ark Conference & Events, Basingstoke WIFI: ArkWIFI Password: Geneva!18 @LymphomaAction #LymphomaConf The 100,000 Genomes Project Genomic medicine: what might it mean for lymphoma treatment in the future? Aim of this talk To discuss the 100,000 Genomics Project To signpost reliable sources of information on genomic medicine (UK based sites) To discuss what impact the use of genomics will have in the future in lymphoma Supporting people affected by lymphatic cancer Lymphoma Action Ensuring everyone affected by lymphoma in the UK has the best possible information, support, treatment and care. Help people with lymphoma and their families by providing reliable information and the right support. Help doctors and nurses so that they can provide the best care possible to people with lymphoma. So what do we say about genomic medicine? What information is available about genomics & lymphoma? Not much… Supporting people affected by lymphatic cancer The 100,000 Genomes Project & the future of genomic medicine Genomics England was set up to deliver the 100,000 Genomes Project. This project will sequence 100,000 whole genomes from NHS patients with rare diseases, and their families, as well as patients with common cancers. Genomics England was announced by Jeremy Hunt, Former Secretary of State for Health and Social Care, as part of the NHS 65th birthday celebrations on 5 July 2013. Genomics and Personalised Medicine: NHS Alliance Supporting people affected by lymphatic cancer The 100,000 Genomes Project & the future of genomic medicine Statement from the launch press conference: “The NHS has a long track record as a leader in medical science advances and it must continue to push the boundaries by unlocking the power of DNA data. “The UK will become the first ever country to introduce this technology in its mainstream health system – leading the global race for better tests, better drugs and above all better, more personalised care to save lives.” Jeremy Hunt, Former Secretary of State for Health and Social Care Film: Genomics and Personalised Medicine: NHS Alliance Supporting people affected by lymphatic cancer The 100,000 Genomes Project: Very ambitious • Genomics England will be efficient, flexible, and able to move quickly as the market changes. It will contract with others for most of its needs including sample collection, analysis and data storage but crucially, it will maintain clear responsibility for data protection. • Genomics England will manage contracts for specialist UK-based companies, universities and hospitals to supply services on sequencing, data linkage and analysis. It will also strictly manage secure storage of personal data in accordance with existing NHS rules designed to securely protect patient information. Supporting people affected by lymphatic cancer The 100,000 Genomes Project: Very ambitious Lots of information and film resources available https://www.genomicsengland.co.uk/about-genomics-england/ Supporting people affected by lymphatic cancer The 100,000 Genomes Project: Why include cancer? • Cancer can be described as a genomic disease. • It is caused by changes to DNA which lead to cells dividing uncontrollably. • By comparing the DNA sequence from a patient’s tumour and healthy cells, we can provide insight into the exact nature and genomic changes that are associated with an individual’s cancer. • The results can be used by clinicians to help with both diagnosis and treatment choice. Whole genome sequencing (WGS) can also begin to show which patients are unlikely to respond to a particular treatment – saving unnecessary medication and toxic side effects. Supporting people affected by lymphatic cancer The 100,000 Genomes Project: Why include cancer? Continued… • Genomics is helping to deliver precision medicine – with a real impact on patients and their health outcomes. By the end of the programme we expect to return WGS results to participants in a clinically meaningful timescale. During the early stages, most patients taking part will not benefit personally. But taking part will improve our understanding of cancer and improve care for the future. Supporting people affected by lymphatic cancer Haematological malignancies? Over to Graham! Supporting people affected by lymphatic cancer Haematological malignancies? Supporting people affected by lymphatic cancer Trusted sources of information Stick to trusted UK based sources of information • Genomics England www.genomicsengland.co.uk/ • Lymphoma Action www.lymohoma-action.org.uk • Bloodwise https://bloodwise.org.uk/ • NHS Choices https://www.nhs.uk/ • Genetic Alliance UK https://www.geneticalliance.org.uk/our-work/diagnosis/my-condition-my- dna/ Supporting people affected by lymphatic cancer.
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