Br J Vener Dis: first published as 10.1136/sti.60.5.352 on 1 October 1984. Downloaded from

Br J Vener Dis 1984; 60:352-6

Abstracts

These selected abstracts and titlesfrom the world literature are arranged in thefollowing sections: Syphilis and other treponematoses (clinical and Trichomoniasis treatment; serology and biologicalfalsepositive Candidosis phenomenon; pathology and experimental) Gonorrhoea (clinical; microbiology; treatment) Other sexually transmitted diseases Chlamydial infections Public health and social aspects Non-specific genital infection Miscellaneous Reiter's disease

and midline lumber pain that was worse and a prolonged transit time. The illness Syphilis and other when lying supine. Five months before subsided without treatment after four days. treponematoses (clinical and admission she had a non-itchy dry rash on Similar episodes occurred during the treatment) her trunk and extremities, with following year at four to eight week between five and 15 mm in diameter. intervals. Clinical findings on admission were of After one year he was found to have Penicillin treatment of early syphilis II diminished position sense in the lower perianal and mouth ulcers, hair loss, JF MAHONEY, RC ARNOLD, BL STERNER, ET AL extremities and increased pinprick sense hearing loss with tinnitus, and blurred (Staten Island, New York, USA). JAMA below the T5 dermatone. Muscle tone in the vision with papilloedema. A Venereal 1984; 251:2005-10. legs was also diminished. She had an Disease Research Laboratory (VDRL) test extensor plantar response on the left. The gave a positive result at a titre of 1/64. His Penicillin and early syphilis cranial nerves and arms gave normal results cerebrospinal fluid (CSF) showed: cells HL ARNOLD (Honolulu, Hawaii, USA). to neurological tests. 124 x 106/1 (all lymphocytes), protein con- JAMA 1984; 251: 2011-3. A sample of cerebrospinal fluid was centration 0 39 g/l, and a positive VDRL obtained, and test results showed: total cells test result. A biopsy of a perianal ulcer 259 x 106/1 with 74% lymphocytes; showed treponemes on silver staining, but Eight years experience of cephradine in protein concentration 2 34 g/l. For some an intestinal biopsy, although showing the treatment of syphilis reason no tests for syphilis were performed. villous atrophy and inflammatory cells in A THEODORIDIS, A VAGENA, A VARELZIDIS, Her leg weakness became a flaccid para- the lamina propria, showed no treponemes AND J CAPETANAKIS (University of Athens plegia, and only then was a rapid plasmid either by silver or fluorescent staining. http://sti.bmj.com/ School of Medicine, Athens, Greece). reagin test performed, which gave a positive He was given 20 MU penicillin a day for Current Therapeutic Research 1984; result. A Venereal Disease Research 10 days with steroid cover initially. After 12 35:184-7. Laboratory test on the CSF then gave a days' treatment his CSF cell count was positive result with a titre of 1/16. normal but the VDRL test result remained Secondary syphilis mimicking systemic She was given intravenous penicillin (but positive. Two months after treatment a lupus erythematosus no quantity or duration is stated or whether small bowel biopsy had reverted to nearly to cover a normal. Further questioning disclosed that DM SKILLRUD AND TW BUNCH (Mayo Clinic, any steroids were given possible Rochester, Minnesota, USA). Arthritis Herxheimer reaction) and made a partial he had a cold sore in a nasiolabial fold two on October 1, 2021 by guest. Protected copyright. 26: 1529-31. recovery, her position sense remaining months before his illness began, which had Rheum 1983; impaired. The authors also discuss different healed spontaneously. This is a very rare treatment regimens for neurosyphilis. manifestation of secondary syphilis. Transverse myelitis due to GD Morrison G D Morrison meningovascular syphilis EP HARRIGAN, TJ McLAUGHLIN, AND RG Syphilitic enteritis FELDMAN (Boston University School of D SCHLOSSBERG, FR RUDY, FW JACKSON, AND Syphilis (pathology and Medicine, Boston, Massachusetts, USA). LB DUMALAG (Polyclinic Medical Center, Arch Neurol 1984;41:337-8. Harrisburg, Pennsylvania, USA). Arch experimental) Intern Med 1984;144:811-4. The authors describe the case of a 51 yea r Immunisation of rabbits with Spirochaeta old woman admitted to hospital with a on e The authors report the history of a 40 year aurantia does not induce resistance to month history of constipation, urinar)y old man who complained of passing four to Treponema pallidum retention, and overflow, and a two weekk six watery stools a day and of fever, nausea, S GRAVES, L DRUMMOND, AND R STRUGNELL history of numbness in the buttockrs and vomiting. The stools did not contain (Monash University Medical School, extending gradually down each leg. She haeI blood or mucus. Barium studies showed Prahran, Victoria, Australia). Sex Transm painful tingling in her feet when walking prominent folds in the upper small bowel Dis 1984;11: 1-5. 352 Br J Vener Dis: first published as 10.1136/sti.60.5.352 on 1 October 1984. Downloaded from

Abstracts 353 Rabbits were immunised with viable Spiro- Gonococcal infections in Gabon (Haut- Arthritis in rabbits induced by killed chaeta aurantia, a free living, facultative Ogoove) Neisseria gonorrhoeae and gonococcal anaerobic spirochete that is similar in some F YVERT, JY RIOU, E FROST, AND B IVANOFF lipopolysaccharide biochemical characteristics to Treponema (Centre International de R&herce DL GOLDENBERG, JI REED, AND PA RICE pallidum, a parasitic, microaerophilic Medicale, Franceville, Gabon). Pathol (Boston University School of Medicine, spirochete. Single and multiple immunis- Biol (Paris) 1984; 32: 80-4. Boston, USA). J Rheumatol 1984; 11: 3-8. ations with living S aurantia, with or with- out Freund's incomplete adjuvant, Freund's complete adjuvant, or heat killed T pallidum, were carried out over a four Gonorrhoea (microbiology) Lipopolysaccharide banding patterns of month period. Living S aurantia was Neisseria meningitidis and Neisseria neither toxic nor virulent for rabbits. Antigen detection for the diagnosis of gonorrhoeae Immunised rabbits produced a high level of gonorrhoea TR PARR Jr AND LE BRYAN (University of agglutinating antibody to S aurantia but no WE STAMM, B COLE, C FENNELL, ETAL Calgary, Calgary, Alberta, Canada). J Clin antibody to Tpallidum, as assessed by the (Harborview Medical Center, Seattle, Microbiol 1984; 19:558-60. T pallidum h'emagglutination test. Washington, USA). J Clin Microbiol Immunised rabbits were challenged with 1984; 19:399-403. multiple intradermal inoculations of 100 viable T pallidum (Nichols strain) and Il-lactamase producing Neisseria compared with unimmunised rabbits Rapid confirmatory identification of gonorrhoeae similarly infected. Immunisation with S Neisseria gonorrhoeae with lectins and KG SINGH, G SINGH, P KAUR, SS PANDEY, AND aurantia did not protect against Tpallidum chromogenic substances D PAL (Banaras Hindu University, infection. Thus S aurantia appears not to be DM YAJKO, A CHU, AND WK HADLEY Varanasi, Uttar Pradesh, India). Indian J suitable as a potential against (University of California, San Francisco, Med Res 1984; 79:337-9. infection with Tpallidum. California, USA). J Clin Microbiol Authors' summary 1984; 19: 380-2. Binding of Neisseria gonorrhoea by lectin Antigenic variation during infection with like receptors on human phagocytes Enumeration of Treponema pallidum cells Neisseria gonorrhoeae: detection of KF KINANE, DM WEIR, CC BLACKWELL, AND FP cultivated in vitro by an enzyme-linked antibodies to surface proteins in sera of WINSTANLEY (University of Edinburgh immunosorbent assay patients with gonorrhoea School of Medicine, Edinburgh, UK). J DL COX, RA MOECKLI, AND KM KEANEY (SRI K ZAK, J-L DIAZ, D JACKSON, AND JE HECKELS Clin Lab Immunol 1984; 13:107-10. International, Menlo Park, California, (Southampton General Hospital, USA). Infect Immun 1984;44:103-6. Southampton, Hants, UK). J Infect Dis 1984; 149:166-74. Validity of an enzyme immunoassay for http://sti.bmj.com/ Efficacy of aztreonam in treatment of detection of Neisseria gonorrhoeae experimental syphilis in rabbits Serum sensitivity of Neisseria antigens CJ PAPASIAN, WR BARTHOLOMEW, AND D SA LUKEHART, S BAKER-ZANDER, AND KK gonorrhoeae: the role of HOLMES (University of Washington, lipopolysaccharide AMSTERDAM (Erie County Laboratory, Seattle, Washington, USA). Antimicrob WM SHAFER, K JOINER, LF GUYMON, ETAL Buffalo, New York, USA). J Clin Agents Chemother 1984;25:390-1. (Emory University School of Medicine, Microbiol 1984; 19:347-50. Atlanta, Georgia, USA). J Infect Dis

1984; 149:175-83. on October 1, 2021 by guest. Protected copyright. Inhibition of anion transport in human Purification and partial characterisation erythrocytes by pilated Neisseria Gonorrhoea (clinical) of the opacity-associated proteins of gonorrhoeae GM WISEMAN, CF MARTIN, AND PJ McNICOL Neisseria gonorrhoeae (University of Manitoba, Winnipeg, Cutaneous gonococcal abscess: a case MS BLAKE AND EC GOTSCHLICH (Rockefeller Manitoba, Canada). Can J Microbiol report University, New York, USA). J Exp Med 1984; 30:52-6. NJ FIUMARA AND R EISEN (Massachusetts 1984; 159:452-61. Department of Public Health, Boston, Massachusetts, USA). Sex Transm Dis 1984; 11: 34-5. Common pathways of invasion of Conservation of peptide structure of outer mucosal barriers by Neisseria gonorrhoeae membrane protein-macro molecular and Neisseria meningitidis complex from Neisseria gonorrhoeae ZA McGEE AND DS STEPHENS (University of MV HANSEN AND CE WILDE III (Indiana Disseminated gonococcal infection Utah School of Medicine, Salt Lake City, University School of Medicine, (editorial) Utah, USA). Survey and Synthesis of Indianapolis, Indiana, USA). Infect Lancet 1984; i: 832. Pathology Research 1984; 3: 1-10. Immun 1984; 43:839-43. Br J Vener Dis: first published as 10.1136/sti.60.5.352 on 1 October 1984. Downloaded from

354 British Journal of Venereal Diseases Common f-lactamase specifying plasmid Polymorphonuclear leukocytes (PMNs) in A colposcopic and histological study of in Haemophilus ducreyi and Neisseria the Gram stained urethral smears of 236 experimental chiamydial cervicitis in gonorrhoeae consecutive sexually active men without marmosets B ANDERSON, WL ALBRITTON, J BIDDLE, AND gonorrhoea were analysed quantitatively. AP JOHNSON, MJ HARE, GD WILBANKS, ETAL SR JOHNSON (Centers for Disease Control, The frequency distribution of the highest (Clinical Research Centre, Watford Road, Atlanta, Georgia, USA). Antimicrob count of PMNs per high power field Harrow, Middlesex, UK). Br J Exp Agents Chemother 1984; 25:296-7. showed a count of four PMNs to be the cut Pathol 1984; 65: 59-66. off point separating men with urethritis Antimicrobial susceptibility of strains of from those without urethritis. This cut off Neisseria gonorrhoeae isolated in Rome point correlated well with the presence of MM FANTAZIA, E FELITICI, AND F MONDELLO Chiamydia trachomatis as well as with (Istituto Superiore Sanita, Rome, Italy). turbid urine. However, the PMN count in Reiter's disease Microbiologica 1984; 7:79-84. the Gram stained urethral smear was found to be more sensitive than the appearance of the urine in the diagnosis of urethritis Aortic insufficiency in Reiter's syndrome among those with minimal symptoms and of juvenile onset Gonorrhoea (treatment) signs and not harboring C trachomatis. O HUBSCHER AND JGV SUSINI (Center for This study also showed a close similarity as Medical Education and Clinical regards clinical features and PMN count in Investigation, Buenos Aires, Argentina). J A comparison of rosoxacin and ampicillin Gram stained urethral smears between Rheumatol 1984; 11:94-5. and probenecid in the treatment of those harbouring Ureaplasma urealyticum uncomplicated gonorrhoea and those with no organisms. AI COHEN, MF REIN, AND RC NOBLE Authors' (University of Kentucky, College of summary Medicine, Lexington, Kentucky, USA). Sex Transm Dis 1984; 11:24-7. Trichomoniasis a Laboratory acquired gonococcal Characteristics of Gram-negative Trichomonal in women anaerobe isolated from men with non- vaginitis Nigerian conjunctivitis: successful treatment with BO OGUNBANJO AND AO OSOBA (University single-dose ceftriaxone gonococcal urethritis College Hospital, Ibadan, Nigeria). Trop TR ZAJDOWICZ, SB KERBS, SW BERG, AND WO EAR FONTAINE, SP BORRIELLO, D TAYLOR- Geogr Med 1984;36:67-70. HARRISON (US Naval Hospital, San Diego, ROBINSON, AND HA DAVIES (Clinical California, USA). Sex Transm Dis 1984; Research Centre, Watford Road, Harrow, 11:28-9. Middlesex, UK). J Med Microbiol 1984; 17: 129-40. Ceftizoxime (FK-749) is effective therapy Candidosis for urethritis caused by penicillinase- http://sti.bmj.com/ producing Neisseria gonorrhoeae WO HARRISON, PL SANCHEZ, DJ LANCASTER, Epididymitis: studies on its aetiology and Ketoconazole in the prevention of ETAL (US Naval Hospital, San Diego, pathogenesis with special consideration of experimental candidal vaginitis California, USA). Sex Transm Dis 1984; Chlamydia trachomatis and Ureaplasma JD SOBEL AND G MULLER (Medical College 11:30-1. urealyticum of Pennsylvania, Philadelphia, HC BECKER, W WEIDNER, HG SCHIEFER, ETAL Pennsylvania, USA). Antimicrob Agents (University of Giessen, Giessen, FRG). Chemother 1984; 25:281-2. Rosoxacin in the therapy of Dtsch Med Wochenschr 1984; 109:569-75. uncomplicated gonorrhoea on October 1, 2021 by guest. Protected copyright. B ROMANOWSKI, TW AUSTIN, FLM PATTISON, ETAL (Social Hygiene Service, Edmonton, A comparison between oral ketoconazole Alberta, Canada). Antimicrob Agents and topical miconazole in the treatment of Chemother 1984; 25:455-7. vaginal candidiasis J PUOLAKKA AND R TUIMACA (University of Oulu, Oulu, Finland). Acta Obstet Non-specific genital infection Chilamydial infections Gynecol Scand 1983;62:575-8.

Diagnosis of urethritis: role of Reinfection of the mouse genital tract polymorphonuclear leukocyte counts in with Chiamydia trachomatis: the Inhibition and killing of Candida albicans Gram-stained smears relationship of antibody to immunity in vitro by five imidazoles in clinical use OP ARYA, H MALLINSON, BE ANDREWS, AND M TUFFREY, P FALDER, AND D TAYLOR- E LEFLER AND DA STEVENS (Santa Clare M SILLIS (Royal Liverpool Hospital, ROBINSON (Clinical Research Centre, Valley Medical Center, San Jose, Liverpool, UK). Sex Transm Dis Watford Road, Harrow, Middlesex, UK). California, USA). Antimicrob Agents 1984; 11: 10-7. Br J Exp Pathol 1984; 65:51-8. Chemother 1984; 25:450-4. Br J Vener Dis: first published as 10.1136/sti.60.5.352 on 1 October 1984. Downloaded from

Abstracts 355 Prevalence of genital Genital virus infections: nuisance or Genital herpes in pregnancy potentially lethal? T BASAR, VL BHARGAVA, Y PANDE, AND A SINGER, PG WALKER, AND DJ McCANCE The use of monoclonal antibodies to P SETH (All India Institute of Medical (Royal Northern Hospital, London N7, differentiate isolates of herpes simplex Science, New Delhi, India). Indian J Med UK). Br Med J 1984; 288:735-6. types 1 and 2 by neutralisation and Res 1984; 79:327-32. reverse passive haemagglutination tests Comparison of media for the primary EA BUCKMASTER, MP CRANAGE, CS McLEAN, Incidence of herpes simplex RRA COOMBES, AND A MINSON (University of virus types 1 isolation of Haemophilus ducreyi Cambridge, Cambridge, UK). J Med Virol and 2 in penile lesions of college men H NSANZE, FA PLUMMER, ABN MAGGWA, ET 1984; 13:193-6. JJ DOCHERTY, MA LOHSE, MF DELLARIA, ET AL (Department of Medical Microbiology, AL (Penn State University Microbiology University of Nairobi, Nairobi, Kenya). Program, University Park, Pennsylvania, Sex Transm Dis 1984; 11:6-9. USA). J Med Virol 1984;13:163-70. Detection of in clinical specimens by an enzyme linked Monoclonal antibodies reactive with all immunosorbent assay strains of Haemophilus ducreyi TG LAWRENCE, DB BUDZKO, AND BW WILCKE EJ HANSEN AND TA LOFTUS (University of (Michigan Department of Public Health, Other sexually transmitted Texas Health Science Center, Dallas, Lansing, Michigan, USA). Am J Clin diseases Texas, USA). Infect Immun 1984; 44:196-8. Pathol 1984;81:339-40. An enzyme linked immunosorbent assay Human virus type 16 and early Cluster of cases in the acquired immune for the detection of herpes simplex virus is cervical neoplasia deficiency syndrome. Patients linked by described. The test can be performed in CP CRUM, H IKENBERG, RM RICHART, AND sexual contact. L GISSMAN (Columbia University College four hours, does not require specialised DM AUERBACH, WW DARROW, HW JAFFE, AND equipment, and uses relatively inexpensive of Physicians and Surgeons, New York, JW CURRAN (Centers for Disease Control, and commercially available reagents. It USA). N Eng J Med 1984; 310:880-2. Atlanta, Georgia, USA). Am J Med 1984; detected herpes simplex virus (HSV) in 51 %o 76:487-91. of specimens found to be positive by cell Flat (condylomata) of the uterine culture. In contrast direct immuno- cervix are sometimes cytologically atypical fluorescence detected HSV in only 1 lo of and have abnormal mitotic figures; they are cell culture positive specimens. It also has thought to be possible precursors of cancer the advantage of detecting non-viable virus. of the cervix. Flat warts are caused by any 0 D Morrison of a number of types of human papilloma- Public health and social (HPVs), one of which (HPV 16) has been previously associated with invasive aspects cancer of the cervix. To determine whether A double blinded study of medium to HPV 16 is also associated with flat warts General considerations on endemic http://sti.bmj.com/ long term safety of Inosiplex in the with abnormal mitoses, we analysed 23 flat treponematosis in the rural Sahel region treatment of recurrent genital herpes virus warts by DNA-hybridisation techniques for of Upper Volta disease the presence of HPV 16 and other HPV L MONJOUR, P DRUILHE, A FRIBOURG-BLANC, WH WICKETT Jr, RD MILLER, F HOEHLERETAL types, and correlated the results with the ETAL (Groupe Hospitalier Piti& (University of California, Irvine Orange, histology. Of 10 lesions with abnormal Salpetriere, F-75013, Paris, France). Acta California, USA). Current Therapeutic mitotic figures, seven contained HPV 16, Trop (Basel) 1983;40:375-82. Research 35: 177-83. and one contained another type of HPV.

1984; on October 1, 2021 by guest. Protected copyright. Of 13 lesions without abnormal mitotic Four village populations in Upper Volta figures, only one contained HPV 16, and were studied by the authors. Three villages seven contained other of were in the Sahel region and one in the Genital herpes infection in pregnant types HPV. women We conclude that the presence of HPV 16 Sudan region. The Sahel region villages of near term correlates with the presence of abnormal Oursi (inhabited by Songhrais farmers and AJ JACOB, J EPSTEIN, DL MADDEN, AND mitotic in flat warts of the their families) and Boulel (inhabited JL SEVER figures cervix, by (NINCDS, Bethesda, MIaryland, and that this type of is a precursor Rinibes farmers and their families) were USA). Obstet Gynecol 1984; 63:480-4. of invasive cancer of the cervix. contrasted with the village of Timbolo- Authors' summary Gargassa, inhabited by the semi-nomadic Bellahs (who are somewhat related to the Syndrome d'immunod6ficience acquise Waragwarag Touaregs). These latter (AIDS) revele par un herpes genital Plasmid mediated tetracycline resistance in villagers live 10 km from their water supply. severe. A propos de deux cas Haemophilus ducreyi The Sudan region village of Donse is J De MAUBEUGE, F MASCART-LEMONE, WL ALBRITTON, IW MACLEAN, LA SLANEY, ET occupied by Mossi tribespeople .who are N CLUMECK, ET AL (Hopital Universitaire AL (Centers for Disease Control, Atlanta, also farmers. de Saint Pierre, Brussels, Belgium). Georgia, USA). Antimicrob Agents Of 895 people examined, 373 lived at Dermatologica 1984; 168:105-I1. Chemother 1984; 25: 187-90. Oursi, 144 at Boulel, 118 at Timbolo- Br J Vener Dis: first published as 10.1136/sti.60.5.352 on 1 October 1984. Downloaded from

356 British Journal of Venereal Diseases

Gargassa, and 260 at Donse. An indirect years 97% were positive. Congenital not use this practice had a prevalence of immunofluorescent test for antitreponemal syphilis was rare (one 6 month child in 38% positive serology. antibody was carried out along with a Timbolo Gargassa). No cases of yaws were G D Morrison clinical examination for signs of venereal or found in the Sahel region. Clinical signs of endemic syphilis. bejel were found in 4% of positive patients Prostitution and sexually transmitted The Oursi villagers had a prevalence of at Oursi, 20%o at Boulel, and 39% at disease positive tests of 12 60%o overall, being low Timbolo Gargassa. No clinical evidence of WH PATTERSON (Royal North Shore up to 9 years old, but reaching a peak at 40. bejel was found at Donse where the Hospital, Sydney, Australia). Med J Aust The overall prevalence at Boulel was prevalence of positive serology was only 1984; 140:252. 42-6%; after the age of 40 it was 72-5%o. 3.4%0. The authors wonder whether the The village with the worst incidence was communal use of drinking water skins at Gonorrhoea in a Sydney house of Timbolo Gargassa, where 66 6/o of 3 year Timbolo Gargassa may be a cause of the prostitution old children (the number examined at that high incidence of infection. A neighbouring B DONOVAN (Sydney, Australia). Med J age is not stated) were positive but by 24 village of the same nomadic tribe who do Aust 1984; 140:268-71. http://sti.bmj.com/ on October 1, 2021 by guest. Protected copyright.