Generic Premium

Total Page:16

File Type:pdf, Size:1020Kb

Generic Premium Member education Generic Premium With Generic Premium, you have coverage for low-cost generic drugs, plus some of the most common brand drugs. That means you can get the medicine you need, while saving money. Member education What is Generic Premium? How does Generic Premium work? Generic Premium can help you lower your prescription costs Talk to your doctor before you switch or stop taking any by covering most generic drugs. Some brand drugs are drugs. If you and your doctor agree that a covered drug is a covered by Generic Premium too. They include drugs that good option, you’ll need a new prescription. You can choose treat common conditions like high blood pressure, diabetes, to fi ll the prescription through home delivery or at a local high cholesterol, ulcers and more. So you can choose from a pharmacy. wide range of quality drugs. * Required by the U.S. Food and Drug Administration (FDA). Generics can help you save Generic Premium encourages you to use generic drugs. Why? Generics and their brand versions have the same active ingredient, strength and dose. Generics must meet the same high standards for purity, quality, safety and strength.* Plus, generics normally cost 30 to 60% less than the brand versions. With generics, you get the same quality for less money. Drug coverage at a glance The Generic Premium drug list includes products used for the health needs and conditions below, plus many more. See the next pages for a list of covered drugs. • Attention defi cit hyperactivity • High cholesterol disorder (ADHD) • Infections • Arthritis • Osteoporosis • Asthma • Overactive bladder • Birth control • Pain • Depression • Prenatal vitamins • Diabetes drugs and supplies • Seizures • Enlarged prostate • Sleep aids • Glaucoma • Ulcers • High blood pressure 2 | Generic Premium Generic drugs are listed in all ST = Step therapy is needed. lowercase letters. You may need to try another drug before we’ll provide coverage for Brand drugs are listed with a first the medicine. capital letter. DO = Dose optimization is needed. TIER 1 amlodipine besylate (Norvasc)* Tier 1 drugs have the lowest This usually means that you take DO QL copay. Many Tier 1 drugs are the drug once a day instead of contraceptives – all prescription generics. amlodipine besylate/atorvastatin twice a day. strength, self administered generic (Caduet)* contraceptives Tier 2 drugs have a medium copay * Generic versions of these drugs amlodipine besylate/benazepril cough and cold preparations – and offer a good value. are covered. The brand name in (Lotrel)* all prescription strength, self parenthesis is only for reference. administered, generic cough and amoxapine (Asendin)* Tier 3 drugs have the highest cold preparations amoxicillin trihydrate (Amoxil, copay. Many of these drugs treat ^ These drugs often require your pancreatic enzymes – all prescription Trimox, various)* complex, ongoing conditions and doctor to carefully monitor your may require special handling. strength, self administered, generic amoxicillin trihydrate/potassium dose to make sure the drug pancreatic enzymes clavulanate, ER (Augmentin, XR)* works best for you. In general, PA = Prior authorization is needed. PKU – all prescription strength, self you shouldn’t switch between amphetamine salt combo In this case, you must receive administered, generic PKU formulas (Adderall)* the brand and generic versions approval before the drug vitamins – all prescription strength, of these drugs. Your plan covers ampicillin trihydrate (Principen)* is covered. self administered, generic vitamins both the brand and generic anagrelide hcl (Agrylin)* versions. QL = Quantity limits are needed. antipyrine/benzocaine/glycerin Some drugs have limits on the (Auralgan)* † Once a generic is available, amount you receive for each acarbose (Precose)* aspirin/codeine phosphate the brand version will not prescription or each month. be covered. acebutolol hcl (Sectral)* atovaquone/proguanil acetaminophen/caffeine/butalbital (Malarone)* Key (Fioricet)* QL atenolol (Tenormin)* acetaminophen/codeine (Tylenol w/ atenolol/chlorthalidone Codeine)* QL (Tenoretic)* bromfenac (Xibrom)* carvedilol (Coreg)* acetaminophen/Phenyltoloxamine atorvastatin (Lipitor)* DO, QL budesonide EC (Entocort EC)* cefaclor (Ceclor, Ceclor CD)* (Dologesic, various)* atropine sulfate (Isopto Atropine)* bromocriptine mesylate (Parlodel)* cefadroxil hydrate (Duricef)* acetazolamide (Diamox)* azathioprine (Imuran)* bumetanide (Bumex)* cefdinir (Omnicef)* acetic acid (VoSol)* azelastine (Optivar)* QL buprenorphine (Subutex)* QL cefpodoxime proxetil (Vantin)* acetic acid/aluminum acetate azelastine (Astelin Nasal)* QL (Domeboro)* bupropion hcll (Wellbutrin, cefprozil (Cefzil)* azithromycin (Zithromax)* QL acetic acid/hydrocortisone Wellbutrin SR)* cefuroxime axetil (Ceftin)* bacitracin/polymyxin b sulfate (VoSol HC)* bupropion HCl (Wellbutrin XL)* DO, QL cephalexin monohydrate (Keflex)* (Polysporin Ointment)* (XL only) acetylcysteine (Mucomyst)* chloral hydrate (Somnote)* baclofen (Lioresal)* buspirone HCl (Buspar)* acyclovir (Zovirax)* chlordiazepoxide hcl (Librium)* balsalazide disodium butalbital/acetaminophen/caffeine adapalene (Differin)* chlorhexidine gluconate (Peridex)* belladonna alkaloids/phenobarbital (Esgic-Plus)* chloroquine phosphate (Aralen)* albuterol sulfate (Proventil)* (Donnatal)* butalbital/aspirin/caffeine (Fiorinal)* chlorothiazide (Diuril)* albuterol/ipratropium nebulizer soln benazepril hcl (Lotensin)* butorphanol (Stadol)* (Duoneb)* chlorpromazine hcl (Thorazine)* benazepril/hydrochlorothiazide cabergoline (Dostinex)* alclometasone dipropionate (Lotensin HCT)* chlorpropamide (Diabinese)* (Aclovate)* calcipotriene (Dovonex Oint.)* benzonatate (Tessalon Perles)* chlorthalidone (Hygroton)* alendronate (Fosamax)* QL captopril (Capoten)* benzoyl peroxide (Benzagel, chlorzoxazone (Parafon Forte DSC)* alfuzosin (Uroxatral)* captopril/hydrochlorothiazide Benzac AC, various)* (Capozide)* cholestyramine/aspartame allopurinol (Zyloprim)* benztropine mesylate (Cogentin)* carbamazepine (Carbatrol, Tegretol, (Questran Light)* alprazolam, ER (Xanax, Xanax XR)* betamethasone dipropionate Epitol)^ cholestyramine/sucrose (Questran)* amantadine hcl (Symmetrel)* (Diprosone, Diprolene, Diprosone)* carbamazepine, ER (Tegretol XR)* choline salicylate/magnesium amcinonide (Cyclocort)* betamethasone valerate (Betatrex)* carteolol (Ocupress)* salicylate (Tricosal)* amiloride (Midamor)* betametheasone dipropionate/ carbidopa/levodopa (Sinemet, ciclopirox (Loprox Shampoo)* propylene glycol (Diprolene AF)* amiloride/hydrrocholorthiazide Sinemet CR)* ciclopirox (Penlac)* (Moduretic)* betaxolol hcl (Betoptic)* carbidopa/levodopa/entacapone cilostazol (Pletal)* aminophylline bethanechol chloride (Urecholine)* (Stalevo)* cimetidine – prescription only amiodarone hcl (Cordarone, bisoprol/hydrochlorothiazide (Ziac)* carisoprodol (Soma)* (Tagamet)* Pacerone)^ bisoprolol fumarate (Zebeta)* carisoprodol/aspirin (Soma ciprofloxacin hcl (Cipro)* QL amitriptyline hcl (Elavil)* brimonidine tartrate (Alphagan)* Compound)* ciprofloxacin hcl drops (Ciloxan)* Generic Premium | 3 citalopram hydrobromide desoximetasone (Topicort)* erythromycin base (Ilotycin)* fluoxetine hcl 10, 20, 40mg only (Celexa)* DO, QL dexamethasone (Decadron)* erythromycin base/benzoyl peroxide (Prozac)* DO, QL citric acid/potassium citrate dexamethasone sodium phosphate (Benzamycin)* fluphenazine hcl (Prolixin)* (Polycitra - K)* (Decadron)* erythromycin base/ethanol (A/T/S)* flurazepam hcl (Dalmane)* citric acid/sodium citrate (Bicitra)* dextroamphetamine sulfate, ER erythromycin base/ethanol (Erycette)* flurbiprofen (Ansaid)* clarithromycin, ER (Biaxin, Biaxin XL)* (Dexedrine, Dextrostat)* erythromycin ethylsuccinate (E.E.S.)* flurbiprofen sodium (Ocufen)* clidinium/chlordiazepoxide (Librax)* diazepam (Valium)* erythromycin fluticasone nasal spray (Flonase)* QL clindamycin hcl (Cleocin HCl)* diazepam rectal (Diastat)^ ethylsuccinate/sulfisoxazole fluticasone propionate (Cutivate)* clindamycin phosphate (Cleocin T)* diclofenac potassium (Cataflam)* (Pediazole)* fluvastatin (lescol)* DO clindamycin/benzoyl peroxide diclofenac sodium (Voltaren, Voltaren escitalopram (Lexapro)* DO, QL fluvoxamine maleate (Luvox)* DO (Benzaclin)* Ophth.)* estazolam (ProSom)* folic acid (Folvite)* clobetasol propionate (Clobex Lotion, dicloxacillin sodium (Dynapen)* estradiol (Estrace)* Shampoo)* fosinopril sodium (Monopril)* dicyclomine hcl (Bentyl)* estradiol (Climara)* clobetasol propionate (Cormax)* fosinopril/hydrochlorothiazide diflorasone diacetate (Psorcon)* estradiol/norethindrone (Activella)* (Monopril HCT)* clobetasol propionate (Temovate)* diflunisal (Dolobid)* estrogen, esterified/ furosemide (Lasix)* clobetasol propionate/emollient digoxin (Lanoxin)* methyltestosterone (Syntest D.S.)* (Temovate-E)* gabapentin (Neurontin)* dihydroergotamine mesylate estrogen, esterified/ galantamine (Razadyne, ER)* clomipramine hcl (Anafranil)* (D.H.E.45, Migranal)* methyltestosterone (Syntest H.S.)* gemfibrozil (Lopid)* clonazepam (Klonopin)* diltiazem hcl (Cardizem, estropipate (Ogen)* gentamicin sulfate (Garamycin)* clonidine hcl (Catapres)* Cardizem LA, Tiazac, Cardizem SR, ethambutol hcl (Myambutol)* gianvi (Yaz)* clonidine patch (Catapres-TTS)* Cardizem CD)* DO ethosuximide (Zarontin)^ glimepiride (Amaryl)* clopidogrel (Plavix)* QL diphenhydramine – prescription etidronate (Didronel)* strength (Benadryl)* glipizide, ER (Glucotrol, Glucotrol XL)* clorazepate dipotassium etodolac (Lodine)* (Tranxene T-Tab)* diphenoxylate hcl/atropine sulfate
Recommended publications
  • Chlorpromazine-Induced Cataract and Corneal Pigmentation
    Case Report Chlorpromazine-induced cataract and corneal pigmentation Chlorpromazine (CPZ) is a low-potency neuroleptic used bution was symmetrical in both eyes. Two independent clini- in the treatment of various psychiatric disorders.1 Chlorpro- cians documented the condition. The pupils were dilated with mazine-induced cataract and corneal pigmentation was first 1% tropicamide for retinoscopy. A dilatation of only 4 mm could described by Greiner & Berry in 1964.2 The prevalence in pa- be achieved. Fundus examination by indirect ophthalmoscopy tients treated over time with large doses of CPZ therapy, ranges was normal. Systemic examination was normal; apart from a from 15% to 74%. Though other low-potency neuroleptics like few extrapyramidal symptoms there were no other side-ef- thioridazine and fluphenazine have been reported to cause fects of CPZ, including skin discoloration. Investigations in- pigmentary changes, characteristic corneal and lenticular pig- cluding liver function tests and peripheral smear were nor- mentation is predominantly if not exclusively a side-effect of mal. With subjective correction, the patient’s vision improved CPZ. We report a case of a 45-year-old female with ocular to 6/9. With the psychiatrist’s consultation, CPZ was substi- effects due to long-term CPZ therapy for bipolar disease. tuted with trifluoperazine. Case report Discussion A 45-year-old female had been taking treatment for manic- Chlorpromazine is an aliphatic phenothiazine used in all depressive psychosis with chlorpromazine 300 mg per day for types of psychosis, especially schizophrenia. The adverse ef- 25 years. In addition, she was found to have received lithium fects include drowsiness, lethargy, postural hypotension, an- 300 mg and haloperidol 5 mg, both twice daily for florid psy- ticholinergic side-effects, infertility and extrapyramidal symp- chotic symptoms.
    [Show full text]
  • Penetration of Synthetic Corticosteroids Into Human Aqueous Humour
    Eye (1990) 4, 526--530 Penetration of Synthetic Corticosteroids into Human Aqueous Humour C. N. 1. McGHEE,1.3 D. G. WATSON, 3 1. M. MIDGLEY, 3 M. 1. NOBLE, 2 G. N. DUTTON, z A. I. FERNl Glasgow Summary The penetration of prednisolone acetate (1%) and fluorometholone alcohol (0.1%) into human aqueous humour following topical application was determined using the very sensitive and specific technique of Gas Chromatography with Mass Spec­ trometry (GCMS). Prednisolone acetate afforded peak mean concentrations of 669.9 ng/ml within two hours and levels of 28.6 ng/ml in aqueous humour were detected almost 24 hours post application. The peak aqueous humour level of flu­ orometholone was S.lng/ml. The results are compared and contrasted with the absorption of dexamethasone alcohol (0.1%), betamethasone sodium phosphate (0.1 %) and prednisolone sodium phosphate (0.5%) into human aqueous humour. Topical corticosteroid preparations have been prednisolone acetate (1.0%) and fluorometh­ used widely in ophthalmology since the early alone alcohol (0.1 %) (preliminary results) 1960s and over the last 10 years the choice of into the aqueous humour of patients under­ preparations has become larger and more going elective cataract surgery. varied. Unfortunately, data on the intraocular penetration of these steroids in humans has SUbjects and Methods not paralleled the expansion in the number of Patients who were scheduled to undergo rou­ available preparations; indeed until recently, tine cataract surgery were recruited to the estimation of intraocular penetration has study and informed consent was obtained in been reliant upon extrapolation of data from all cases (n=88), Patients with corneal disease animal models (see Watson et ai., 1988, for or inflammatory ocular conditions which bibliography).
    [Show full text]
  • Non-Steroidal Drug-Induced Glaucoma MR Razeghinejad Et Al 972
    Eye (2011) 25, 971–980 & 2011 Macmillan Publishers Limited All rights reserved 0950-222X/11 www.nature.com/eye 1,2 1 1 Non-steroidal drug- MR Razeghinejad , MJ Pro and LJ Katz REVIEW induced glaucoma Abstract vision. The majority of drugs listed as contraindicated in glaucoma are concerned with Numerous systemically used drugs are CAG. These medications may incite an attack in involved in drug-induced glaucoma. Most those individuals with narrow iridocorneal reported cases of non-steroidal drug-induced angle.3 At least one-third of acute closed-angle glaucoma are closed-angle glaucoma (CAG). glaucoma (ACAG) cases are related to an Indeed, many routinely used drugs that have over-the-counter or prescription drug.1 Prevalence sympathomimetic or parasympatholytic of narrow angles in whites from the Framingham properties can cause pupillary block CAG in study was 3.8%. Narrow angles are more individuals with narrow iridocorneal angle. The resulting acute glaucoma occurs much common in the Asian population. A study of a more commonly unilaterally and only rarely Vietnamese population estimated a prevalence 4 bilaterally. CAG secondary to sulfa drugs is a of occludable angles at 8.5%. The reported bilateral non-pupillary block type and is due prevalence of elevated IOP months to years to forward movement of iris–lens diaphragm, after controlling ACAG with laser iridotomy 5,6 which occurs in individuals with narrow or ranges from 24 to 72%. Additionally, a open iridocorneal angle. A few agents, significant decrease in retinal nerve fiber layer including antineoplastics, may induce thickness and an increase in the cup/disc ratio open-angle glaucoma.
    [Show full text]
  • [email protected]
    SAFETY DATA SHEET Revision Date 13-Jul-2016 Version 1 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING Product identifier Product Name Pred Forte Other means of identification Product Code FP61 Synonyms Prednisolone Acetate Recommended use of the chemical and restrictions on use Recommended Use Corticosteroid This safety data sheet is written to provide health, safety and environmental information for people handling this formulated product in the workplace. It is not intended to provide information relevant to medicinal use of the product. In this instance patients should consult prescribing information/package insert/product label or consult their pharmacist or physician. For health and safety information for individual ingredients used during manufacturing, refer to the appropriate safety data sheet for each ingredient. Details of the supplier of the safety data sheet Manufacturer ALLERGAN 400 Interpace Parkway, Morris Corporate Center III Parsippany, NJ 07054, USA +1-800-272-5525 E-mail address [email protected] Emergency telephone number Emergency Telephone Call CHEMTREC Day or Night Within USA or Canada: 1-800-424-9300 Outside USA and Canada: +1-703-741-5970 (collect calls accepted) 2. HAZARDS IDENTIFICATION Classification OSHA Regulatory Status This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Reproductive toxicity Category 2 Effects on or via lactation Yes Label elements Emergency Overview Danger Hazard statements H362 - May cause harm to breast-fed
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • Prednisolone Also Binds to Transcortin • Other Synthetic GS Only Bind to Albumin
    PK/PD considerations for corticosteroids P L Toutain, National Veterinary School, Toulouse, France Wuhan October 2015 1 Anti-inflammatory drugs Corticosteroids NSAIDs 2 Glucocorticoids: main properties • Glucocorticosteroids (GCS) are broad and potent anti- inflammatory drugs. • They are extensively used to mitigate or suppress inflammation associated with a variety of conditions especially joint and respiratory system inflammation. • GCs are not curative: • GCs are only palliative symptomatic treatments and chronic use of GCs can be, in fine , detrimental • GCs possess many other pharmacological properties (not reviewed in this presentation) 3 The cortisol or hydrocortisone 4 Cortisol : An endogenous hormone and a surrogate endpoint of the duration of the GCS effects; it physiology should be understood to use properly GCS 5 Cortisol synthesis • All GCs used in therapeutics are synthetic derivatives of cortisol. • Cortisol (hydrocortisone) is synthesized in the adrenal cortex and it is the main corticosteroid hormone in most species. 6 Steroids synthesis by the adrenal gland Aldosterone Cortisol Androgens Epinephrine (adrenalin) 7 Cortisol ou Hydrocortisone structure – activity relationship Three structural properties are required for a GC activity (i.e. for cortisol to bind to GC receptor) 8 Cortisol (hydrocortisone) • Minimal information on cortisol physiology (secretion, distribution & elimination ) needs to be known to understand the clinical pharmacology of GCS 9 Plasma cortisol • Cortisol levels are very different in domestic species • Pattern of secretion – Circadian rhythm (h) – Pulsatilty (minute) 10 Plasma cortisol level Plasma concentration (ng/mL) 600 500 400 300 Series1 200 100 0 1 2 3 4 5 11 Plasma cortisol levels: circadian rhythm & pulsatility Toutain et al. Domestic.Anim.Endocrinol.
    [Show full text]
  • Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Cr
    Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Crizotinib (PF-02341066) 1 4 55 Docetaxel 1 5 98 Anastrozole 1 6 25 Cladribine 1 7 23 Methotrexate 1 8 -187 Letrozole 1 9 65 Entecavir Hydrate 1 10 48 Roxadustat (FG-4592) 1 11 19 Imatinib Mesylate (STI571) 1 12 0 Sunitinib Malate 1 13 34 Vismodegib (GDC-0449) 1 14 64 Paclitaxel 1 15 89 Aprepitant 1 16 94 Decitabine 1 17 -79 Bendamustine HCl 1 18 19 Temozolomide 1 19 -111 Nepafenac 1 20 24 Nintedanib (BIBF 1120) 1 21 -43 Lapatinib (GW-572016) Ditosylate 1 22 88 Temsirolimus (CCI-779, NSC 683864) 1 23 96 Belinostat (PXD101) 1 24 46 Capecitabine 1 25 19 Bicalutamide 1 26 83 Dutasteride 1 27 68 Epirubicin HCl 1 28 -59 Tamoxifen 1 29 30 Rufinamide 1 30 96 Afatinib (BIBW2992) 1 31 -54 Lenalidomide (CC-5013) 1 32 19 Vorinostat (SAHA, MK0683) 1 33 38 Rucaparib (AG-014699,PF-01367338) phosphate1 34 14 Lenvatinib (E7080) 1 35 80 Fulvestrant 1 36 76 Melatonin 1 37 15 Etoposide 1 38 -69 Vincristine sulfate 1 39 61 Posaconazole 1 40 97 Bortezomib (PS-341) 1 41 71 Panobinostat (LBH589) 1 42 41 Entinostat (MS-275) 1 43 26 Cabozantinib (XL184, BMS-907351) 1 44 79 Valproic acid sodium salt (Sodium valproate) 1 45 7 Raltitrexed 1 46 39 Bisoprolol fumarate 1 47 -23 Raloxifene HCl 1 48 97 Agomelatine 1 49 35 Prasugrel 1 50 -24 Bosutinib (SKI-606) 1 51 85 Nilotinib (AMN-107) 1 52 99 Enzastaurin (LY317615) 1 53 -12 Everolimus (RAD001) 1 54 94 Regorafenib (BAY 73-4506) 1 55 24 Thalidomide 1 56 40 Tivozanib (AV-951) 1 57 86 Fludarabine
    [Show full text]
  • Pharmacokinetics of Ophthalmic Corticosteroids
    British Journal ofOphthalmology 1992; 76: 681-684 681 MINI REVIEW Br J Ophthalmol: first published as 10.1136/bjo.76.11.681 on 1 November 1992. Downloaded from Pharmacokinetics of ophthalmic corticosteroids Corticosteroids have been used by ophthalmologists with an identical vehicle, the aqueous humour concentrations of increasing frequency over the past 30 years, with the these steroids are almost identical.'9 None the less it is concomitant development of a diverse range of drop, essential when considering such empirical data, to recall that ointment, subconjunctival, and oral preparations. Though the systemic anti-inflammatory effect of both betamethasone the clinical benefits and side effects of such corticosteroid and dexamethasone is five to seven times that of predniso- preparations have been well documented, their basic lone.39"' The local anti-inflammatory potency of ocular pharmacokinetics in the human eye have yet to be fully steroids has yet to be fully investigated and whilst early work established. Indeed most of our pharmacokinetic knowledge suggested that prednisolone acetate 1% had the greatest anti- of these drugs has been elucidated by extrapolation of data inflammatory effect in experimental keratitis,'7 later studies obtained from rabbit experiments.1-26 These results can be demonstrated that fluorometholone acetate in a 1% formu- significantly disparate from human data because of the lation was equally efficacious in the same model.26 However, thinner rabbit cornea, lower rabbit blink rate, effect of prednisolone
    [Show full text]
  • Aetna Formulary Exclusions Drug List
    Covered and non-covered drugs Drugs not covered – and their covered alternatives 2020 Advanced Control Plan – Aetna Formulary Exclusions Drug List 05.03.525.1B (7/20) Below is a list of medications that will not be covered without a Key prior authorization for medical necessity. If you continue using one of these drugs without prior approval, you may be required UPPERCASE Brand-name medicine to pay the full cost. Ask your doctor to choose one of the generic lowercase italics Generic medicine or brand formulary options listed below. Preferred Options For Excluded Medications1 Excluded drug name(s) Preferred option(s) ABILIFY aripiprazole, clozapine, olanzapine, quetiapine, quetiapine ext-rel, risperidone, ziprasidone, VRAYLAR ABSORICA isotretinoin ACANYA adapalene, benzoyl peroxide, clindamycin gel (except NDC^ 68682046275), clindamycin solution, clindamycin-benzoyl peroxide, erythromycin solution, erythromycin-benzoyl peroxide, tretinoin, EPIDUO, ONEXTON, TAZORAC ACIPHEX, esomeprazole, lansoprazole, omeprazole, pantoprazole, DEXILANT ACIPHEX SPRINKLE ACTICLATE doxycycline hyclate capsule, doxycycline hyclate tablet (except doxycycline hyclate tablet 50 mg [NDC^ 72143021160 only], 75 mg, 150 mg), minocycline, tetracycline ACTOS pioglitazone ACUVAIL bromfenac, diclofenac, ketorolac, PROLENSA acyclovir cream acyclovir (except acyclovir cream), valacyclovir ADCIRCA sildenafil, tadalafil ADZENYS XR-ODT amphetamine-dextroamphetamine mixed salts ext-rel†, dexmethylphenidate ext-rel, dextroamphetamine ext-rel, methylphenidate ext-rel†, MYDAYIS,
    [Show full text]
  • Acepromazine and Chlorpromazine As Pharmaceutical-Grade Alternatives to Chlorprothixene for Pupillary Light Reflex Imaging in Mice
    Journal of the American Association for Laboratory Animal Science Vol 59, No 2 Copyright 2020 March 2020 by the American Association for Laboratory Animal Science Pages 197–203 Acepromazine and Chlorpromazine as Pharmaceutical-grade Alternatives to Chlorprothixene for Pupillary Light Reflex Imaging in Mice Samantha S Eckley,1 Jason S Villano,1 Nora S Kuo,1 and Kwoon Y Wong2,* Studies of visual responses in isoflurane-anesthetized mice often use the sedative chlorprothixene to decrease the amount of isoflurane used because excessive isoflurane could adversely affect light-evoked responses. However, data are not available to justify the use of this nonpharmaceutical-grade chemical. The current study tested whether pharmaceutical-grade sedatives would be appropriate alternatives for imaging pupillary light reflexes. Male 15-wk-old mice were injected intraperitoneally with 1 mg/kg chlorprothixene, 5 mg/kg acepromazine, 10 mg/kg chlorpromazine, or saline. After anesthetic induction, anes- thesia maintenance used 0.5% and 1% isoflurane for sedative- and saline-injected mice, respectively. A photostimulus (16.0 log photons cm−2 s−1; 470 nm) was presented to the right eye for 20 min, during which the left eye was imaged for consensual pupillary constriction and involuntary pupil drift. Time to immobilization, loss of righting reflex, physiologic parameters, gain of righting reflex, and degree of recovery were assessed also. The sedative groups were statistically indistinguishable for all measures. By contrast, pupillary drift occurred far more often in saline-treated mice than in the sedative groups. Fur- thermore, saline-treated mice took longer to reach maximal pupil constriction than all sedative groups and had lower heart rates compared with chlorpromazine- and chlorprothixene-sedated mice.
    [Show full text]
  • Tropicamide Tropicamide Eye Drops
    Minims® Tropicamide Tropicamide Eye Drops Consumer Medicine Information Tell your doctor if you have or What is in this leaflet Before you use Minims have had any of the following Tropicamide This leaflet answers some common medical conditions: questions about Minims * glaucoma (high pressure in the Tropicamide, including how to use When you must not use it eye) the eye drops. * fast heartbeat or any heart Do not use Minims Tropicamide if It does not contain all the available condition or had heart surgery. you have an allergy to: information. It does not take the Tell your doctor if you are place of talking to your doctor or * any medicine containing pregnant or are breast-feeding. pharmacist. tropicamide Your doctor will discuss with you * any of the ingredients listed at the All medicines have benefits and the risks and benefits involved. risks. Your doctor has weighed the end of this leaflet. Tell your doctor if you wear risks of you using Minims Some of the symptoms of an allergic contact lenses. Tropicamide against the benefits they reaction may include: You should not wear contact lenses expect it will have for you. * shortness of breath while using this medicine. If you have any concerns about * wheezing or difficulty breathing using this medicine, ask your * swelling of the face, lips, tongue If you have not told your doctor doctor or pharmacist. about any of the above, tell or other parts of the body him/her before you start using Keep this leaflet with the medicine. * rash, itching or hives on the skin.
    [Show full text]
  • 208151Orig1s000
    CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 208151Orig1s000 SUMMARY REVIEW NDA 208151, ISOPTO Atropine (atropine sulfate ophthalmic solution) 1% Cycloplegia, Mydriasis, Penalization of the healthy eye in the treatment of amblyopia Division Director Summary Review Material Reviewed/Consulted OND Action Package, including: Names of discipline reviewers Medical Officer Review Wiley Chambers, William Boyd 9/13/2016 CDTL Review William Boyd, Wiley Chambers 11/29/2016 Statistical Review Abel Eshete, Yan Wang 11/8/2016 Pharmacology Toxicology Review Aaron Ruhland, Lori Kotch 11/7/2016 CMC Review Haripada Sanker, Milton Sloan, Maotang Zhou, Denise Miller, Vidya Pai, Om Anand, Erin Andrews, Chunchun Zhang, Paul Perdue 10/12/2016, 11/10/2016 Clinical Pharmacology Review Abhay Joshi, Philip Colangelo 11/9/2016 OPDP/DPDP Carrie Newcomer 11/7/2016 OSI/DGCPC N/A Proprietary Name Michelle Rutledge, Yelena Maslov, Lubna Merchant 6/1/2016 Conditionally acceptable letter Todd Bridges 6/2/2016 OSE/DMEPA Michelle Rutledge, Yelena Maslov 6/8/2016 OSE/DDRE N/A OSE/DRISK N/A Project Manager Michael Puglisi OND=Office of New Drugs CDTL=Cross-Discipline Team Leader OSI/DGCPC=Office of Scientific Investigations/Division of Good Clinical Practice Compliance OPDP/DPDP=Office of Prescription Drug Promotion/Division of Prescription Drug Promotion OSE= Office of Surveillance and Epidemiology DMEPA=Division of Medication Error Prevention and Analysis DDRE= Division of Drug Risk Evaluation DRISK=Division of Risk Management Page 2 of 24 Reference ID: 4021108 NDA 208151, ISOPTO Atropine (atropine sulfate ophthalmic solution) 1% Cycloplegia, Mydriasis, Penalization of the healthy eye in the treatment of amblyopia Division Director Summary Review Signatory Authority Review Template 1.
    [Show full text]