DOCSLIB.ORG

Cancer Drugs -Oral Blood Thinners (Anticoagulants) (Antineoplastics)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Cancer Drugs -Oral Blood Thinners (Anticoagulants) (Antineoplastics) BLOOD CANCER DRUGS-OTHER (ANTINEOPLASTICS) BLOOD MODIFIERS CANCER DRUGS-OTHER (ANTINEOPLASTICS) anagrelide (P) NEUPOGEN SYLATRON (P) pentoxifylline (M) (P) PROCRIT CANCER DRUGS -ORAL BLOOD THINNERS (ANTICOAGULANTS) (ANTINEOPLASTICS) COUMADIN (M) CANCER DRUGS -ORAL (ANTINEOPLASTICS) enoxaparin (M) anastrozole fondaparinux (P) AFINITOR FRAGMIN (M) bicalutamide PRADAXA (P) (M) BOSULIF warfarin (P) CAPRELSA (M) STROKE PREVENTION exemestane ERIVEDGE (P) (M) GLEEVEC (P) clopidogrel (P) ticlopidine (M) HYCAMTIN INLYTA (P) (M) CANCER DRUGS-OTHER letrozole NEXAVAR (P) (ANTINEOPLASTICS) (P) REVLIMID (P) CANCER DRUGS-OTHER SPRYCEL (ANTINEOPLASTICS) JAKAFI (P) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication CANCER DRUGS -ORAL CENTRAL NERVOUS SYSTEM (ANTINEOPLASTICS) ANTI-PARKINSON DRUGS CANCER DRUGS -ORAL (M) (ANTINEOPLASTICS) pramipexole ropinirole (M) STIVARGA (P) selegiline (M) SUTENT (P) TARCEVA (P) ATTENTION DEFICIT DISORDER (ADD), TASIGNA (P) NARCOLEPSY (P) TEMODAR (M) (P) amphetamine/dextroamphetamine THALOMID (M) (P) dexmethylphenidate TYKERB (M) (P) dextroamphetamine VOTRIENT (M) (P) methamphetamine XALKORI (M) (P) methylphenidate sr XELODA (M) XTANDI (P) methylphenidate ZELBORAF (P) (P) SEIZURE MEDICATIONS (ANTICONVULSANTS) ZOLINZA (P) ZYTIGA carbamazepine extended release (M) carbamazepine (M) CENTRAL NERVOUS SYSTEM clonazepam (M) diazepam (M) ALZHEIMER'S DRUGS divalproex (M) (M) (M) divalproex sodium ARICEPT-23 (M) (M) ethosuximide donepezil (M) NAMENDA (M) gabapentin lamotrigine (M) (M) ANTI-PARKINSON DRUGS levetiracetam phenytoin (M) amantadine (M) primidone (M) APOKYN topiramate (M) bromocriptine (M) valproic acid (M) levodopa/carbidopa (M) zonisamide (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication CENTRAL NERVOUS SYSTEM DIABETES & HIGH BLOOD SUGAR SLEEP AIDS ANTIDIABETIC DRUGS temazepam LEVEMIR (M) zaleplon metformin xr (M) zolpidem metformin (M) nateglinide (M) CHEST PAIN & HEART DISEASE NOVO INSULIN (M) NOVOLOG (M) CHEST PAIN & HEART DISEASE ONGLYZA (M) (M) (M) piogliazone/metformin isosorbide dinitrate pioglitazone (M) isosorbide mononitrate (M) (M) (M) PRANDIN nitroglycerin sl VICTOZA (M) transdermal nitroglycerin (M) BLOOD SUGAR TEST STRIPS DIABETES & HIGH BLOOD SUGAR ACCU-CHEK meter test strips (Q,M) ANTIDIABETIC DRUGS ONE TOUCH meter test strips (Q,M) (M) acarbose DISEASES BYETTA (M) (M) glimepiride ARTHRITIS (RHEUMATOID) glipizide extended release (M) glipizide (M) ENBREL (P) glyburide and metformin (M) HUMIRA (P) glyburide (M) leflunomide (M) JANUMET XR (M) methotrexate (M) JANUMET (M) JANUVIA (M) BONE DISEASE KOMBIGLYZE (M) alendronate (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication DISEASES ENT (EAR/NOSE/THROAT) BONE DISEASE ALLERGIES & COLDS (NASAL) calcitonin salmon nasal spray (M) fluticasone propionate (M) etidronate (M) triamcinolone (M) EVISTA (M) ibandronate (M) ALLERGIES (ORAL) (M) GOUT desloratadine levocetirizine (M) allopurinol (M) COLCRYS (M) MISCELLANEOUS HEPATITIS lidocaine viscous INTRON A (M) EYE PEGASYS (P) ribavirin ANTI-INFLAMMATORY DROPS MULTIPLE SCLEROSIS DRUGS prednisolone acetate COPAXONE (P,M) COMBINATION EYE INFECTION DROPS REBIF (P,M) dexamethasone/neomycin/polymyxin THYROID DISEASE dexamethasone/tobramycin levothyroxine (M) EYE INFECTION DROPS liothyronine (M) methimazole (M) ciprofloxacin propylthiouracil (M) ENT (EAR/NOSE/THROAT) ALLERGIES & COLDS (NASAL) azelastine KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication EYE EYE EYE INFECTION DROPS MISCELLANEOUS DRUGS ofloxacin ketorolac tromethamine 0.5% polymyxin b/bacitracin RESTASIS (M) polymyxin b/trimethoprim polymyxin/neomycin/gramicidin sol. HEART RHYTHM DISORDERS sodium sulfacetamide tobramycin drops HEART RHYTHM DISORDERS trifluridine (M) VIGAMOX acebutolol amiodarone (M) (M) GLAUCOMA DRUGS digoxin disopyramide controlled release (M) acetazolamide (M) disopyramide (M) ALPHAGAN P 0.1% (M) propafenone (M) AZOPT (M) sotalol (M) brimonidine 0.15% (M) COMBIGAN (M) HIGH BLOOD PRESSURE & HEART (M) dorzolamide/timolol DISEASE dorzolamide (M) (M) latanoprost ACE INHIBITORS levobunolol (M) LUMIGAN (M) benazepril (M) methazolamide (M) enalapril (M) pilocarpine (M) lisinopril (M) timolol (M) moexipril (M) quinapril (M) MISCELLANEOUS DRUGS trandolapril (M) atropine ALPHA BETA BLOCKERS flurbiprofen ketoralac tromethamine, 0.4 % carvedilol (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication HIGH BLOOD PRESSURE & HEART HIGH BLOOD PRESSURE & HEART DISEASE DISEASE ALPHA BETA BLOCKERS CALCIUM CHANNEL BLOCKERS doxazosin (M) nisoldipine (M) labetalol (M) verapamil extended release (M) prazosin (M) verapamil (M) ANGIOTENSIN II BLOCKERS COMBINATION DRUGS DIOVAN (M) amlodipine/benazepril (M) EDARBI (M) atenolol/chlorthalidone (M) irbesartan (M) benazepril/hctz (M) losartan (M) bisoprolol/hctz (M) EDARBYCLOR (M) BETA BLOCKERS irbesartan/hctz (M) (M) (M) lisinopril/hctz acebutolol (M) (M) losartan/hctz atenolol (M) (M) moexipril/hct BYSTOLIC valsartan/hctz (M) metoprolol xl (M) (M) metoprolol SYMPATHOLYTICS nadolol (M) propranolol extended rel. (M) clonidine (M) propranolol (M) guanfacine (M) CALCIUM CHANNEL BLOCKERS WATER PILLS OR DIURETICS amlodipine (M) furosemide (M) diltiazem extended release (M) hydrochlorothiazide (M) diltiazem (M) metolazone (M) nifedipine extended release (M) spironolactone (M) nifedipine sustained release (M) torsemide (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication HIGH BLOOD PRESSURE & HEART HIV & AIDS DISEASE COMBINATION DRUGS WATER PILLS OR DIURETICS KALETRA (M) (M) triamterene/hctz (M) lamivudine/zidovudine STRIBILD (M) TRIZIVIR (M) HIGH CHOLESTEROL DRUGS (M) (ANTILIPEMICS) TRUVADA NON-NUCLEOSIDE REVERSE TRANSCRIPTASE HIGH CHOLESTEROL DRUGS INHIBITORS (ANTILIPEMICS) (M) (M) EDURANT atorvastatin (M) (M) INTELENCE cholestyramine (M) (M) nevirapine colestipol (M) (M) RESCRIPTOR fluvastatin (M) (M) SUSTIVA gemfibrozil lovastatin (M) (M) NUCLEOSIDE REVERSE TRANSCRIPTASE pravastatin INHIBITORS simvastatin (M) abacavir (M) HIV & AIDS didanosine (M) EMTRIVA (M) MISCELLANEOUS FUZEON (M) HIVID (M) (M) ATRIPLA lamivudine (M) (M) ISENTRESS stavudine (M) (M) SELZENTRY VIDEX Powder (M) VIREAD (M) COMBINATION DRUGS zidovudine capsules (M) zidovudine tablets and syrup (M) COMPLERA (M) (M) EPZICOM PROTEASE INHIBITORS APTIVUS (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication HIV & AIDS HORMONES PROTEASE INHIBITORS MISCELLANEOUS CRIXIVAN (M) desmopressin acetate tablets (M) FORTOVASE, INVIRASE (M) LEXIVA (M) STEROID REPLACEMENT MEDICATION NORVIR (M) PREZISTA (M) hydrocortisone REYATAZ (M) VIRACEPT (M) IMMUNE SYSTEM HORMONES ANTI-REJECTION (IMMUNOSUPPRESSANTS) azathioprine (M) GROWTH cyclosporine (M) (M) (P) mercaptopurine NORDITROPIN (M) SEROSTIM (P) mycophenolate RAPAMUNE (M) (M) HORMONE REPLACEMENT DRUGS tacrolimus ethinyl estradiol/norethindrone (M) INFECTIONS MALE BACTERIAL (CEPHALOSPORINS) ANDRODERM (M) cefuroxime AXIRON (M) cephalexin capsules oxandrolone BACTERIAL (COMBINATION ANTIBIOTICS) MISCELLANEOUS trimethoprim/sulfamethoxazole desmopressin acetate nasal spray (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication INFECTIONS INFECTIONS BACTERIAL (FLUROQUINOLONES) FUNGAL (ANTIFUNGAL DRUGS) ciprofloxacin er itraconazole ciprofloxacin ketoconazole levofloxacin terbinafine BACTERIAL (MACROLIDES) MISCELLANEOUS ANTI-INFECTIVE DRUGS azithromycin suspension (Q) atovaquone/proguanil azithromycin tablets (Q) chloroquine phosphate clarithromycin extended release hydroxychloroquine clarithromycin ZYVOX erythromycin ethylsuccinate TUBERCULOSIS (ANTITUBERCULOSIS DRUG) BACTERIAL (MISCELLANEOUS (M) ANTIBIOTICS) ethambutol isoniazid/rifampin (M) clindamycin metronidazole URINARY TRACT BACTERIAL (PENICILLINS) nitrofurantoin (macrocrystals) nitrofurantoin exten. rel. amoxicillin/clavulanate amoxicillin/pot.clavulanate VIRAL (ANTIVIRAL DRUGS) BACTERIAL (TETRACYCLINES) acyclovir famciclovir doxycycline monohydrate valacyclovir doxycycline VALCYTE minocycline MENTAL HEALTH FUNGAL (ANTIFUNGAL DRUGS) ANTIDEPRESSANTS fluconazole bupropion xl 150mg (M) KEY: Preferred Brand-name Drugs (Tier 2) Generic Drugs (Tier 1) P = Prior Authorization Required, Q = Quantity Limit, M = Maintenance Medication MENTAL HEALTH MENTAL HEALTH ANTIDEPRESSANTS MANIC-DEPRESSION OR BIPOLAR DRUGS bupropion (M) lithium carbonate ext. rel. (M) citalopram (M) clomipramine (M) MISCELLANEOUS DRUGS desipramine (M) escitilopram (M) MISCELLANEOUS DRUGS fluoxetine (M) (M) Novofine needles (M) imipramine (M) mirtapazine orally disintegrating (M) Novotwist needles mirtazapine (M) nortriptyline (M) MUSCLE RELAXERS paroxetine controlled release (M) paroxetine (M) MUSCLE RELAXERS phenelzine (M) protriptyline (M) carisoprodol sertraline (M) cyclobenzaprine tranylcypromine (M) metaxalone venlafaxine (M) methocarbamol tizanidine ANTIPSYCHOTIC DRUGS NARCOLEPSY olanzapine (M) quetiapine fumurate (M) NARCOLEPSY risperidone
Load more

Recommended publications
  • Fasted and Fed State Human Duodenal Fluids: Characterization, Drug Solubility, and Comparison to Simulated Fluids and with Human Bioavailability
    European Journal of Pharmaceutics and Biopharmaceutics 163 (2021) 240–251 Contents lists available at ScienceDirect European Journal of Pharmaceutics and Biopharmaceutics journal homepage: www.elsevier.com/locate/ejpb Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability D. Dahlgren a, M. Venczel b,c, J.-P. Ridoux b,c, C. Skjold¨ a, A. Müllertz d, R. Holm e, P. Augustijns f, P.M. Hellstrom¨ g, H. Lennernas¨ a,* a Department of Pharmaceutical Biosciences, Biopharmaceutics, Uppsala University, Sweden b Global CMC Development Sanofi, Frankfurt, Germany c Global CMC Development Sanofi, Vitry, France d Physiological Pharmaceutics, University of Copenhagen, Copenhagen, Denmark e Drug Product Development, Janssen R&D, Johnson & Johnson, Beerse, Belgium f Drug Delivery and Disposition, KU Leuven, Leuven, Belgium g Department of Medical Sciences, Gastroenterology/Hepatology, Uppsala University, Sweden ARTICLE INFO ABSTRACT Keywords: Accurate in vivo predictions of intestinal absorption of low solubility drugs require knowing their solubility in Bioavailability physiologically relevant dissolution media. Aspirated human intestinal fluids (HIF) are the gold standard, fol­ Food effects lowed by simulated intestinal HIF in the fasted and fed state (FaSSIF/FeSSIF). However, current HIF charac­ Drug solubility terization data vary, and there is also some controversy regarding the accuracy of FaSSIF and FeSSIF for Human intestinal fluids predicting drug solubility in HIF. This study aimed at characterizing fasted and fed state duodenal HIF from 16 Drug absorption Drug dissolution human volunteers with respect to pH, buffer capacity, osmolarity, surface tension, as well as protein, phos­ Drug delivery pholipid, and bile salt content.
    [Show full text]
  • Penetration of Synthetic Corticosteroids Into Human Aqueous Humour
    Eye (1990) 4, 526--530 Penetration of Synthetic Corticosteroids into Human Aqueous Humour C. N. 1. McGHEE,1.3 D. G. WATSON, 3 1. M. MIDGLEY, 3 M. 1. NOBLE, 2 G. N. DUTTON, z A. I. FERNl Glasgow Summary The penetration of prednisolone acetate (1%) and fluorometholone alcohol (0.1%) into human aqueous humour following topical application was determined using the very sensitive and specific technique of Gas Chromatography with Mass Spec­ trometry (GCMS). Prednisolone acetate afforded peak mean concentrations of 669.9 ng/ml within two hours and levels of 28.6 ng/ml in aqueous humour were detected almost 24 hours post application. The peak aqueous humour level of flu­ orometholone was S.lng/ml. The results are compared and contrasted with the absorption of dexamethasone alcohol (0.1%), betamethasone sodium phosphate (0.1 %) and prednisolone sodium phosphate (0.5%) into human aqueous humour. Topical corticosteroid preparations have been prednisolone acetate (1.0%) and fluorometh­ used widely in ophthalmology since the early alone alcohol (0.1 %) (preliminary results) 1960s and over the last 10 years the choice of into the aqueous humour of patients under­ preparations has become larger and more going elective cataract surgery. varied. Unfortunately, data on the intraocular penetration of these steroids in humans has SUbjects and Methods not paralleled the expansion in the number of Patients who were scheduled to undergo rou­ available preparations; indeed until recently, tine cataract surgery were recruited to the estimation of intraocular penetration has study and informed consent was obtained in been reliant upon extrapolation of data from all cases (n=88), Patients with corneal disease animal models (see Watson et ai., 1988, for or inflammatory ocular conditions which bibliography).
    [Show full text]
  • Pharmacokinetic Interactions of Pioglitazone
    Department of Clinical Pharmacology University of Helsinki Finland PHARMACOKINETIC INTERACTIONS OF PIOGLITAZONE Tiina Jaakkola ACADEMIC DISSERTATION To be presented, with the permission of the Medical Faculty of the University of Helsinki, for public examination in Auditorium 2 of Biomedicum, on August 24th, 2007, at 12 noon. Helsinki 2007 JJaakkola_Tiina_vaitos.inddaakkola_Tiina_vaitos.indd 1 117.7.20077.7.2007 221:11:231:11:23 Supervisors: Professor Pertti Neuvonen, MD Department of Clinical Pharmacology University of Helsinki Helsinki, Finland Docent Janne Backman, MD Department of Clinical Pharmacology University of Helsinki Helsinki, Finland Reviewers: Docent Kimmo Malminiemi, MD, MSc Department of Pharmacology, Clinical Pharmacology and Toxicology University of Tampere Tampere, Finland Professor emeritus Pertti Pentikäinen, MD Department of Medicine University of Helsinki Helsinki, Finland Opponent: Professor Kari Kivistö, MD Department of Pharmacology, Clinical Pharmacology and Toxicology University of Tampere Tampere, Finland ISBN 978-952-92-2224-7 (paperback) ISBN 978-952-10-4020-7 (PDF, http://ethesis.helsinki.fi ) Helsinki 2007 Yliopistopaino JJaakkola_Tiina_vaitos.inddaakkola_Tiina_vaitos.indd 2 117.7.20077.7.2007 221:11:551:11:55 JJaakkola_Tiina_vaitos.inddaakkola_Tiina_vaitos.indd 3 117.7.20077.7.2007 221:11:551:11:55 CONTENTS CONTENTS ABBREVIATIONS.......................................................................................................................................... 6 LIST OF ORIGINAL PUBLICATIONS.......................................................................................................
    [Show full text]
  • Pharmacokinetic Interactions of Drugs with St John's Wort
    http://www.paper.edu.cn Pharmacokinetic interactions of Journal of Psychopharmacology 18(2) (2004) 262–276 © 2004 British Association drugs with St John’s wort for Psychopharmacology ISSN 0269-8811 SAGE Publications Ltd, London, Thousand Oaks, CA and New Delhi 10.1177/0269881104042632 Shufeng Zhou Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore. Eli Chan Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore. Shen-Quan Pan Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. Min Huang Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510089, PR China. Edmund Jon Deoon Lee Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore. Abstract There is a worldwide increasing use of herbs which are often cancer patients receiving irinotecan treatment. St John’s wort did not administered in combination with therapeutic drugs, raising the alter the pharmacokinetics of tolbutamide, but increased the incidence potential for herb–drug interactions. St John’s wort (Hypericum of hypoglycaemia. Several cases have been reported that St John’s wort perforatum) is one of the most commonly used herbal antidepressants. A decreased cyclosporine blood concentration leading to organ rejection. literature search was performed using Medline (via Pubmed), Biological St John’s wort caused breakthrough bleeding and unplanned pregnancies Abstracts, Cochrane Library, AMED, PsycINFO and Embase (all from their when used concomitantly with oral contraceptives. It also caused inception to September 2003) to identify known drug interaction with serotonin syndrome when coadministered with selective serotonin- St John’s wort. The available data indicate that St John’s wort is a reuptake inhibitors (e.g.
    [Show full text]
  • [email protected]
    SAFETY DATA SHEET Revision Date 13-Jul-2016 Version 1 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING Product identifier Product Name Pred Forte Other means of identification Product Code FP61 Synonyms Prednisolone Acetate Recommended use of the chemical and restrictions on use Recommended Use Corticosteroid This safety data sheet is written to provide health, safety and environmental information for people handling this formulated product in the workplace. It is not intended to provide information relevant to medicinal use of the product. In this instance patients should consult prescribing information/package insert/product label or consult their pharmacist or physician. For health and safety information for individual ingredients used during manufacturing, refer to the appropriate safety data sheet for each ingredient. Details of the supplier of the safety data sheet Manufacturer ALLERGAN 400 Interpace Parkway, Morris Corporate Center III Parsippany, NJ 07054, USA +1-800-272-5525 E-mail address [email protected] Emergency telephone number Emergency Telephone Call CHEMTREC Day or Night Within USA or Canada: 1-800-424-9300 Outside USA and Canada: +1-703-741-5970 (collect calls accepted) 2. HAZARDS IDENTIFICATION Classification OSHA Regulatory Status This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Reproductive toxicity Category 2 Effects on or via lactation Yes Label elements Emergency Overview Danger Hazard statements H362 - May cause harm to breast-fed
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • ACCOLATE® (Zafirlukast) TABLETS DESCRIPTION
    ACCOLATE® (zafirlukast) TABLETS DESCRIPTION Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist (LTRA), with the chemical name 4-(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3-ylmethyl)-3-methoxy-N-o­ tolylsulfonylbenzamide. The molecular weight of zafirlukast is 575.7 and the structural formula is: The empirical formula is: C31H33N3O6S Zafirlukast, a fine white to pale yellow amorphous powder, is practically insoluble in water. It is slightly soluble in methanol and freely soluble in tetrahydrofuran, dimethylsulfoxide, and acetone. ACCOLATE is supplied as 10 and 20 mg tablets for oral administration. Inactive Ingredients: Film-coated tablets containing croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, povidone, hypromellose, and titanium dioxide. CLINICAL PHARMACOLOGY Mechanism of Action: Zafirlukast is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD4 and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma. Patients with asthma were found in one study to be 25­ 100 times more sensitive to the bronchoconstricting activity of inhaled LTD4 than nonasthmatic subjects. In vitro studies demonstrated that zafirlukast antagonized the contractile activity of three leukotrienes (LTC4, LTD4 and LTE4) in conducting airway smooth muscle from laboratory animals and humans. Zafirlukast prevented intradermal LTD4-induced increases in cutaneous vascular permeability and Reference ID: 3407275 inhibited inhaled LTD4-induced influx of eosinophils into animal lungs. Inhalational challenge studies in sensitized sheep showed that zafirlukast suppressed the airway responses to antigen; this included both the early- and late-phase response and the nonspecific hyperresponsiveness.
    [Show full text]
  • Prednisolone Also Binds to Transcortin • Other Synthetic GS Only Bind to Albumin
    PK/PD considerations for corticosteroids P L Toutain, National Veterinary School, Toulouse, France Wuhan October 2015 1 Anti-inflammatory drugs Corticosteroids NSAIDs 2 Glucocorticoids: main properties • Glucocorticosteroids (GCS) are broad and potent anti- inflammatory drugs. • They are extensively used to mitigate or suppress inflammation associated with a variety of conditions especially joint and respiratory system inflammation. • GCs are not curative: • GCs are only palliative symptomatic treatments and chronic use of GCs can be, in fine , detrimental • GCs possess many other pharmacological properties (not reviewed in this presentation) 3 The cortisol or hydrocortisone 4 Cortisol : An endogenous hormone and a surrogate endpoint of the duration of the GCS effects; it physiology should be understood to use properly GCS 5 Cortisol synthesis • All GCs used in therapeutics are synthetic derivatives of cortisol. • Cortisol (hydrocortisone) is synthesized in the adrenal cortex and it is the main corticosteroid hormone in most species. 6 Steroids synthesis by the adrenal gland Aldosterone Cortisol Androgens Epinephrine (adrenalin) 7 Cortisol ou Hydrocortisone structure – activity relationship Three structural properties are required for a GC activity (i.e. for cortisol to bind to GC receptor) 8 Cortisol (hydrocortisone) • Minimal information on cortisol physiology (secretion, distribution & elimination ) needs to be known to understand the clinical pharmacology of GCS 9 Plasma cortisol • Cortisol levels are very different in domestic species • Pattern of secretion – Circadian rhythm (h) – Pulsatilty (minute) 10 Plasma cortisol level Plasma concentration (ng/mL) 600 500 400 300 Series1 200 100 0 1 2 3 4 5 11 Plasma cortisol levels: circadian rhythm & pulsatility Toutain et al. Domestic.Anim.Endocrinol.
    [Show full text]
  • Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Cr
    Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Crizotinib (PF-02341066) 1 4 55 Docetaxel 1 5 98 Anastrozole 1 6 25 Cladribine 1 7 23 Methotrexate 1 8 -187 Letrozole 1 9 65 Entecavir Hydrate 1 10 48 Roxadustat (FG-4592) 1 11 19 Imatinib Mesylate (STI571) 1 12 0 Sunitinib Malate 1 13 34 Vismodegib (GDC-0449) 1 14 64 Paclitaxel 1 15 89 Aprepitant 1 16 94 Decitabine 1 17 -79 Bendamustine HCl 1 18 19 Temozolomide 1 19 -111 Nepafenac 1 20 24 Nintedanib (BIBF 1120) 1 21 -43 Lapatinib (GW-572016) Ditosylate 1 22 88 Temsirolimus (CCI-779, NSC 683864) 1 23 96 Belinostat (PXD101) 1 24 46 Capecitabine 1 25 19 Bicalutamide 1 26 83 Dutasteride 1 27 68 Epirubicin HCl 1 28 -59 Tamoxifen 1 29 30 Rufinamide 1 30 96 Afatinib (BIBW2992) 1 31 -54 Lenalidomide (CC-5013) 1 32 19 Vorinostat (SAHA, MK0683) 1 33 38 Rucaparib (AG-014699,PF-01367338) phosphate1 34 14 Lenvatinib (E7080) 1 35 80 Fulvestrant 1 36 76 Melatonin 1 37 15 Etoposide 1 38 -69 Vincristine sulfate 1 39 61 Posaconazole 1 40 97 Bortezomib (PS-341) 1 41 71 Panobinostat (LBH589) 1 42 41 Entinostat (MS-275) 1 43 26 Cabozantinib (XL184, BMS-907351) 1 44 79 Valproic acid sodium salt (Sodium valproate) 1 45 7 Raltitrexed 1 46 39 Bisoprolol fumarate 1 47 -23 Raloxifene HCl 1 48 97 Agomelatine 1 49 35 Prasugrel 1 50 -24 Bosutinib (SKI-606) 1 51 85 Nilotinib (AMN-107) 1 52 99 Enzastaurin (LY317615) 1 53 -12 Everolimus (RAD001) 1 54 94 Regorafenib (BAY 73-4506) 1 55 24 Thalidomide 1 56 40 Tivozanib (AV-951) 1 57 86 Fludarabine
    [Show full text]
  • Farmacopea De 2021 (Lista De Medicamentos Cubiertos)
    Planes Medicare Advantage de ConnectiCare Plan ConnectiCare Choice 1 (HMO) Plan ConnectiCare Choice 2 (HMO) Plan ConnectiCare Choice 3 (HMO) Plan ConnectiCare Choice Part B Saver Plan ConnectiCare Flex 1 (HMO-POS) Plan ConnectiCare Flex 2 (HMO-POS) Plan ConnectiCare Flex 3 (HMO-POS) Plan ConnectiCare Passage 1 (HMO) Farmacopea de 2021 (Lista de medicamentos cubiertos) LEA LA SIGUIENTE INFORMACIÓN: ESTE DOCUMENTO CONTIENE INFORMACIÓN SOBRE LOS ME- DICAMENTOS QUE CUBRIMOS EN ESTE PLAN. 00021082, V17 Esta farmacopea se actualizó el 09/01/2021. Para obtener información más reciente o si tiene otras preguntas, comuníquese con Servicios para Miembros de ConnectiCare al 1-800-224-2273, los usuarios de TTY deben llamar al 711, de 8.00 am a 8.00 pm, hora del este, los siete días de la semana, o visite connecticare.com/medicare. Última actualización 09/01/2021 H3528_200567_C Nota para los miembros existentes: Esta farmacopea se ha cambiado desde el año pasado. Revise este documento para asegurarse de que aún se incluyan los medicamentos que usted toma. Cuando esta lista de medicamentos (farmacopea) haga referencia a “nosotros”, “nos” o “nuestro”, significa ConnectiCare. Cuando se refiere a “plan” o “nuestro plan”, significa los planes Medicare Advantage de ConnectiCare. Nuestros planes Medicare Advantage incluyen los planes ConnectiCare Choice 1 (HMO), ConnectiCare Choice 2 (HMO), ConnectiCare Choice 3 (HMO), ConnectiCare Choice Part B Saver, ConnectiCare Flex 1 (HMO-POS), ConnectiCare Flex2 (HMO-POS), ConnectiCare Flex 3 (HMO-POS) y ConnectiCare Passage 1 (HMO). Este documento incluye una lista de los medicamentos (farmacopea) para nuestro plan que se encuentra vigente desde el 09/01/2021 .
    [Show full text]
  • Pharmacokinetics of Ophthalmic Corticosteroids
    British Journal ofOphthalmology 1992; 76: 681-684 681 MINI REVIEW Br J Ophthalmol: first published as 10.1136/bjo.76.11.681 on 1 November 1992. Downloaded from Pharmacokinetics of ophthalmic corticosteroids Corticosteroids have been used by ophthalmologists with an identical vehicle, the aqueous humour concentrations of increasing frequency over the past 30 years, with the these steroids are almost identical.'9 None the less it is concomitant development of a diverse range of drop, essential when considering such empirical data, to recall that ointment, subconjunctival, and oral preparations. Though the systemic anti-inflammatory effect of both betamethasone the clinical benefits and side effects of such corticosteroid and dexamethasone is five to seven times that of predniso- preparations have been well documented, their basic lone.39"' The local anti-inflammatory potency of ocular pharmacokinetics in the human eye have yet to be fully steroids has yet to be fully investigated and whilst early work established. Indeed most of our pharmacokinetic knowledge suggested that prednisolone acetate 1% had the greatest anti- of these drugs has been elucidated by extrapolation of data inflammatory effect in experimental keratitis,'7 later studies obtained from rabbit experiments.1-26 These results can be demonstrated that fluorometholone acetate in a 1% formu- significantly disparate from human data because of the lation was equally efficacious in the same model.26 However, thinner rabbit cornea, lower rabbit blink rate, effect of prednisolone
    [Show full text]
  • Aetna Formulary Exclusions Drug List
    Covered and non-covered drugs Drugs not covered – and their covered alternatives 2020 Advanced Control Plan – Aetna Formulary Exclusions Drug List 05.03.525.1B (7/20) Below is a list of medications that will not be covered without a Key prior authorization for medical necessity. If you continue using one of these drugs without prior approval, you may be required UPPERCASE Brand-name medicine to pay the full cost. Ask your doctor to choose one of the generic lowercase italics Generic medicine or brand formulary options listed below. Preferred Options For Excluded Medications1 Excluded drug name(s) Preferred option(s) ABILIFY aripiprazole, clozapine, olanzapine, quetiapine, quetiapine ext-rel, risperidone, ziprasidone, VRAYLAR ABSORICA isotretinoin ACANYA adapalene, benzoyl peroxide, clindamycin gel (except NDC^ 68682046275), clindamycin solution, clindamycin-benzoyl peroxide, erythromycin solution, erythromycin-benzoyl peroxide, tretinoin, EPIDUO, ONEXTON, TAZORAC ACIPHEX, esomeprazole, lansoprazole, omeprazole, pantoprazole, DEXILANT ACIPHEX SPRINKLE ACTICLATE doxycycline hyclate capsule, doxycycline hyclate tablet (except doxycycline hyclate tablet 50 mg [NDC^ 72143021160 only], 75 mg, 150 mg), minocycline, tetracycline ACTOS pioglitazone ACUVAIL bromfenac, diclofenac, ketorolac, PROLENSA acyclovir cream acyclovir (except acyclovir cream), valacyclovir ADCIRCA sildenafil, tadalafil ADZENYS XR-ODT amphetamine-dextroamphetamine mixed salts ext-rel†, dexmethylphenidate ext-rel, dextroamphetamine ext-rel, methylphenidate ext-rel†, MYDAYIS,
    [Show full text]