SUPPLEMENT: Methionine deprivation (MET-stress) induced changes in expression in human CNS tumors as determined by U95Av2 chip oligoarray analysis. Tumor cells were grown in culture in a methionine efficient medium (M) or in a medium in which methionine was replaced with homocyctein (H). The expression of selected in DAOY, SWB61, SWB40, SWB39, and SWB77 (left) in arbitrary units and ratios of expression in the MET-stressed versus control state (right) are shown. Genes whose expression was significantly (p<0.05) changed my MET-stress are shown in bold. Genes whose expression was significantly downregulated by MET-stress are shaded. U133A* and U95 accession numbers. Gene Expression Level (Arbitary Units) Gene Description (accession #) MET-Stressed/Control (ratios)

DAOY(M) DAOY(H) 61(M) 61(H) 40(M) 40(H) 39(M) 39(H) 77(M) 77(H) DESCRIPTION DAOY SWB61 SWB40 SWB39 SWB77 CELL CYCLE RELATED 1705 647 774 191 774 220 199 226 278 115 A1 (X51688) 0.38 0.25 0.28 1.14 0.41 1494 686 1147 532 1275 451 2262 407 1103 585 cyclin A2 (AW276574) 0.46 0.46 0.35 0.18 0.53 3156 1516 453 64 3265 404 497 184 1373 1715 cyclin B1 (M25753) 0.48 0.14 0.12 0.37 1.25 2415 827 2636 959 3009 568 2547 557 1562 1533 cyclin B2 (AF002822) 0.34 0.36 0.19 0.22 0.98 412 1623 781 1914 710 3867 2915 3599 1950 1333 cyclin D1 (X59791) 3.94 2.45 5.45 1.23 0.68 2984 1657 56 227 14 64 1300 1203 154 359 cyclin D2 (D13693) 0.56 4.06 4.51 0.93 2.34 618 1316 583 1660 1697 1161 1748 1008 2082 856 cyclin D3 (M92287) 2.13 2.85 0.68 0.58 0.41 1284 457 2345 1015 1697 700 1677 736 1144 865 Cell division cycle 2 (CDC2) (BC014563) 0.36 0.43 0.41 0.44 0.76 2318 1645 1964 1139 1386 1389 1916 1254 950 930 CDC2-related (M68520) 0.71 0.58 1 0.65 0.98 2335 1857 198 1210 1901 1996 1684 1580 1431 1804 cyclin-dependent kinase 4 (CDK4) (U37022) 0.8 6.12 1.05 0.94 1.26 1078 1112 733 521 1468 896 657 776 458 597 cyclin-dependent kinase 5 (CDK5) (BC005115.1)* 1.03 0.71 0.61 1.18 1.3 23 150 291 390 337 128 310 164 109 24 cyclin-dependent kinase 6 (CDK6) (NM_001259.1)* 6.59 1.34 0.38 0.53 0.22 284 101 139 353 411 100 232 169 766 448 CDK4 inhibitor p18 (p18) (AF041248) 0.35 2.54 0.24 0.73 0.58 775 1238 355 602 1776 1116 1006 438 845 800 cyclin A/CDK2-associated p19 (SKP1) (U33760) 1.6 1.7 0.63 0.44 0.95 33 30 21 26 18 24 31 17 18 24 cyclin A/CDK2-associated p45 (SKP2) (U33761) 0.9 1.25 1.3 0.54 1.3 13 25 59 8 13 15 14 9 10 12 CDK inhibitor p15 (p15) (L36844) 1.87 0.13 1.16 0.65 1.19 3203 1906 1189 1056 3741 1932 2245 1156 2739 1638 cell division cycle 25 (CDC25) (S78187) 0.6 0.89 0.52 0.51 0.6 423 218 66 241 235 160 500 304 412 95 cell division cycle 25A (CDC25A) (M81933) 0.52 3.66 0.68 0.61 0.23 2041 994 2345 1291 3713 919 2082 1159 1750 1206 cell division cycle 25B (CDC25B) (M81794) 0.49 0.55 0.25 0.56 0.69 273 25 38 58 120 80 36 30 48 55 cell division cycle 25C (CDC25C) (M34065) 0.09 1.52 0.67 0.84 1.14 222 263 219 145 148 166 333 80 565 82 cell division cycle 25C splice variant 3 (AJ304506) 1.18 0.66 1.12 0.24 0.15 1718 1111 120 147 601 486 862 535 335 182 proliferating cell nuclear antigen (PCNA) (J05614) 0.65 1.23 0.81 0.62 0.54 938 432 894 349 1014 420 1455 422 749 640 putative mitotic checkpoint kinase (AF05330) 0.46 0.39 0.41 0.29 0.85 673 335 54 45 480 40 98 31 192 32 mitotic checkpoint kinase Bub1 (BUB1) (AF053305) 0.5 0.83 0.08 0.32 0.17 1755 1356 491 456 1052 583 984 508 905 726 mitotic checkpoint kinase Bub3 (BUB3) (AF047473) 0.77 0.93 0.55 0.52 0.8 694 1858 771 1291 960 1539 198 468 455 131 mitotic arrest deficient (MAD1) (U33822.1) 2.68 1.68 1.6 2.37 0.29 1364 668 1099 716 1121 552 2355 827 499 393 mitotic arrest deficient (MAD2) (BC000356.1)* 0.49 0.65 0.49 0.35 0.79 3582 1782 3911 3869 3635 2433 3399 3131 1395 1205 CDC28 1 (CKS1) (BC001425.1)* 0.5 0.99 0.67 0.92 0.86 2205 1911 5720 5063 11011 5167 4285 2747 1854 1312 CDC28 protein kinase 2 (CKS2) (NM_001827.1)* 0.87 0.89 0.47 0.64 0.71 1716 656 1333 1629 3145 680 2310 1100 1638 895 cell division cycle 20 (CDC20) (BC001088.1)* 0.38 1.22 0.22 0.48 0.55 305 323 234 565 332 353 261 188 460 378 tumor endothelial marker 1 precursor (TEM1) (AF279142.1)* 1.06 2.41 1.06 0.72 0.82 1386 636 140 172 324 164 2078 1507 23 147 neuroepithelial cell transforming gene 1 (NET1) (U02081.8)* 0.46 1.22 0.51 0.73 6.29 7 71 122 85 18 45 122 64 82 43 cell division cycle 14 homolog A (CDC14A) (AF000367.1)* 10.76 0.7 2.51 0.53 0.52 54 70 528 130 85 186 128 158 198 78 cell division cycle 14 homolog B (CDC14B) (NM_003671.1)* 1.3 0.25 2.2 1.24 0.39 35 208 66 19 137 199 120 76 193 50 CDC14A2 phosphatase (AF064102.1)* 5.91 0.29 1.46 0.63 0.26 21 8 274 100 193 63 106 17 78 63 CDC14B3 phosphatase (AF064105.2)* 0.37 0.36 0.33 0.16 0.8 778 1082 768 1028 909 1128 1337 1569 657 780 cell division cycle 5 (CDC5L) (NM_001253.1)* 1.39 1.34 1.24 1.17 1.19 332 226 1005 380 508 438 513 333 226 151 activator of S phase kinase (ASK) (AB028069.1)* 0.68 0.38 0.86 0.65 0.67 p53 Related 2105 2077 300 1405 920 1117 1689 1169 937 1265 p53 (M22898) 0.99 4.69 1.21 0.69 1.35 742 550 308 440 374 529 521 180 687 702 p53 binding protein (U82939) 0.74 1.43 1.41 0.35 1.02 1429 4107 2890 7600 1664 4485 1401 2868 810 348 cyclin-dependent kinase inhibitor 1A (p21, Cip1) (U03106) 2.87 2.63 2.7 2.05 0.43 753 757 1730 6282 689 2227 2398 2736 3267 2312 GADD45 (M60974) 1.01 3.63 3.23 1.14 0.71 428 1332 3808 9797 7236 10041 564 1376 955 1354 GADD45 α (Α39617) 3.11 2.57 1.39 2.44 1.42 344 90 1699 760 4029 320 1426 331 241 356 GADD45 β (AF090950.1)* 0.26 0.45 0.08 0.23 1.48 10 516 117 153 108 224 105 644 198 155 GADD45 γ (ΑF079806) 53.79 1.3 2.07 6.13 0.78 786 2707 749 6217 723 2286 1413 3213 1535 1452 GADD34 (U83981) 3.44 8.3 3.16 2.27 0.95 894 1659 846 2768 1086 1705 1385 3273 916 1957 BRCA1 (L78833) 1.86 3.27 1.37 2.36 2.14 281 200 894 885 602 825 476 1420 1008 1001 BRCA2 (U50535) 0.71 0.99 1.37 2.98 0.99 599 2388 184 2800 1838 5225 3287 4450 2128 1901 BCL-1 (M73554) 3.99 15.24 2.84 1.35 0.89 258 162 370 270 166 256 260 198 181 218 BAX alpha (L22473) 0.63 0.73 1.54 0.76 1.2 520 480 851 532 311 610 680 470 473 535 BAX beta (L22474) 0.92 0.63 1.96 0.69 1.13 199 159 162 81 131 263 317 74 157 99 BAX gamma (L22475) 0.8 0.5 2 0.23 0.63 554 420 63 1329 281 594 781 664 453 392 BAX delta (U19599) 0.76 21.16 2.12 0.85 0.87 764 971 730 587 481 583 808 488 376 392 BH3 interacting domain death agonist (BID) (AF042083) 1.27 0.8 1.21 0.6 1.04 174 348 76 117 6 13 33 135 14 23 BCL-2 interacting killer (BIK) (U34584) 2 1.55 2.26 4.1 1.66 653 1040 374 508 465 697 598 563 794 496 BCL2/adenovirus E1B 19kD-interacting protein 2 (BNIP2) (U15173) 1.59 1.36 1.5 0.94 0.62 394 392 723 1935 1474 1821 504 2744 1499 2346 E1B 19K/Bcl-2-binding protein (NIP3) (AF002697) 1 2.68 1.24 5.45 1.56 322 286 547 488 512 382 540 371 337 398 BCL-2 binding component 6 (bbc6) (U66879) 0.89 0.89 0.75 0.69 1.18 600 437 1281 2037 256 767 658 815 620 717 BCL-2 binding component 3 (bbc3) (U82987) 0.73 1.59 3 1.24 1.16 1644 1222 775 3868 3943 6872 2231 9833 4443 7565 BCL2/adenovirus E1B 19kDa-interacting protein 3a (AF079221) 0.74 4.99 1.74 4.41 1.7 449 565 330 239 312 417 566 925 358 276 TNF-induced protein (GG2-1) (NM_014350.1)* 1.06 0.79 1.34 1.35 76 ANTI-APOPTOSIS 203 192 468 94 572 280 73 52 146 244 BCL-2 (M14745) 0.95 0.2 0.49 0.72 1.67 386 358 129 1011 400 530 421 639 444 438 BCL-2, p53 binding protein (BBP/53BP2) (U58334) 0.93 7.85 1.33 1.52 0.99 60 222 110 80 4 61 8 45 26 23 BCL-2 related (BFL-1) (U27467) 3.72 0.73 15.25 5.86 0.86 173 378 874 639 321 425 418 240 516 492 BCL—Xl (Z23115) 2.19 0.73 1.32 0.57 0.95 2010 1683 1452 1757 980 1269 1374 1957 980 961 BCL7B protein (X89985) 0.84 1.21 1.3 1.42 0.98 493 476 156 303 92 205 166 312 148 263 BCL7A protein (X89984) 0.97 1.95 2.23 1.88 1.78 TGF 100 193 299 88 9 10 89 486 305 126 TGF-α (X70340) 1.94 0.29 1.11 5.47 0.41 83 128 368 1098 257 107 457 197 445 279 TGF-β -2 (M19154) 1.54 2.98 0.42 0.43 0.63 1075 1075 101 1248 1561 770 1232 1166 833 1405 TGF-β (Μ38449) 1 12.41 0.49 0.95 1.69 167 79 104 325 415 387 124 383 383 337 TGF-β superfamily receptor type I (L17075) 0.48 3.11 0.93 3.09 0.88 1187 4445 2390 31458 810 8892 4251 28156 1886 2674 TGF-β superfamily protein (AB000584) 3.75 13.16 10.98 6.62 1.42 574 421 316 536 707 988 909 642 770 1217 TGF-β activated kinase 1a (AB009356) 0.73 1.7 1.4 0.71 1.58 992 2363 34 1343 950 1275 1400 904 678 219 TGF-β inducible early growth rasp protein alpha (AF050110) 2.38 39.51 1.34 0.65 0.32 3813 4177 1257 1952 3595 3273 3434 1886 3860 2849 TGF-β receptor interacting protein (U36764) 1.1 1.55 0.91 0.55 0.74 254 343 140 632 61 164 381 464 202 328 TGF-β -receptor associated protein-1 (AF022795T) 1.35 4.5 2.68 1.22 1.62 1176 67 2017 722 1096 792 762 391 909 1022 TGF-β activated kinase (TAK1) (AF21807)* 0.06 0.36 0.72 0.51 1.13 591 1882 466 3776 477 3352 1008 2672 889 1662 TGF-β induced early response (TIEG) (U21847.1)* 3.19 8.1 7.03 2.65 1.87 155 196 496 219 746 531 248 152 626 648 TGF-β induced antiapoptotic factor (TIAF1) (D86970.1)* 1.26 0.44 0.71 0.61 1.03 42154 26790 124 833 102 177 27382 15932 16608 18477 TGF-β induced 68kD (TGFBI) (BC000097.1)* 0.64 6.74 1.73 0.58 1.11 112 161 645 495 98 234 363 188 288 215 glioblastoma-derived T-cell suppressor ( TGF-beta2) (Y00083) 1.44 0.77 2.39 0.52 0.74 175 239 158 403 225 457 311 256 319 318 SMAD5 (AF010607) 1.37 2.55 2.03 0.82 1 322 462 112 242 152 152 187 202 151 136 SMAD7 (AF010193) 1.44 2.15 1 1.08 0.9 339 499 37 375 158 342 192 273 215 270 SMAD2 (U78733) 1.47 10.17 2.16 1.42 1.25 505 717 466 223 184 264 323 292 267 286 SMAD3 (AB004922) 1.42 0.48 1.43 0.9 1.07 215 125 49 62 442 109 127 12 145 140 SMAD6 (AF035528) 0.58 1.26 0.25 0.09 0.96 326 177 915 231 206 205 247 127 227 96 ALK-4 (Z22536) 0.54 0.25 0.99 0.51 0.42 849 1098 678 1020 679 1033 1194 939 653 792 ERK activator (MEK1) (L11284) 1.29 1.51 1.52 0.79 1.21 1556 1607 161 2316 1342 1154 1553 897 2252 2759 ERK activator (MEK2) (L11285) 1.03 14.41 0.86 0.58 1.22 962 922 1659 1015 1207 723 853 1167 733 1035 ERK1 (X60188) 0.96 0.61 0.6 1.37 1.41 1512 1842 912 1869 638 923 1373 1678 768 660 ERK3 (X80692) 1.22 2.05 1.45 1.22 0.86 IGF 11426 1400 44 206 11737 2945 6 19 8219 13889 insulin-like growth factor binding protein 5 (IGFBP5) (L27560) 0.12 4.69 0.4 3.39 1.69 5376 9952 567 600 2247 559 1046 1781 4532 3368 IGFBP4 (U20892) 1.85 1.06 0.25 1.78 0.74 261 176 99 873 3390 1378 1236 835 2377 1580 IGFBP6 (M62402) 0.67 8.81 0.41 0.68 0.67 291 368 26 113 295 247 99 9 1936 1674 IGFBP2 (X16302) 1.27 4.52 0.84 0.09 0.87 501 219 611 103 202 230 135 301 291 276 IGF-2 (X35563) 0.44 0.17 1.13 2.24 0.95 40 2142 488 595 476 501 1554 2916 471 351 IGFBP7 (L19182.1)* 53.81 1.22 1.05 1.88 0.75 809 1005 1021 2324 747 1349 2115 3240 958 1276 IGF-2R IGF-2 receptor (Y00285) 1.24 2.28 1.81 1.53 1.33 VEGF 1864 3741 2171 8457 1695 11183 2332 7473 7519 12679 VEGF (AF024710) 2.01 3.9 6.6 3.2 1.69 347 205 42 359 330 401 239 303 204 580 VEGF-B (U48801) 0.59 8.47 1.22 1.27 2.84 140 275 165 371 328 106 1033 381 27 67 VEGF-C (X94216) 1.96 2.25 0.32 0.37 2.47 389 475 824 295 271 49 247 268 191 219 VEGF receptor/cell surface tyrosine kinase (S77812) 1.22 0.36 0.18 1.08 1.15 1573 1345 2599 2118 2282 3970 922 3533 1669 4294 VEGF related factor isoform VRF186 precursor (VRF) (U43368) 0.86 0.81 1.74 3.83 2.57 TNF 360 616 1468 172 223 155 222 262 224 147 TNF-alpha (X02910) 1.71 0.12 0.69 1.18 0.66 361 315 1327 380 313 337 390 365 292 357 TNF-α converting (U69611.1)* 0.87 0.29 1.08 0.94 1.22 58 495 883 493 667 910 41 454 562 980 TNFRSF1A-associated via death domain (TRADD) (AK090673) 8.51 0.56 1.36 11.2 1.74 2338 1332 2670 2076 2552 1584 657 862 1208 487 tumor necrosis factor, alpha-induced protein 7 (TNFAIP7) 0.57 0.78 0.62 1.31 0.4 602 256 211 225 205 365 442 290 287 294 tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) 0.43 1.07 1.79 0.66 1.02 693 938 946 1051 1326 831 453 819 280 234 tumor necrosis factor, alpha-induced protein 9 (TNFAIP9) 1.35 1.11 0.63 1.81 0.84 892 798 900 1448 2445 2040 762 569 1173 1180 tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) 0.89 1.61 0.83 0.75 1.01 131 1015 150 121 114 90 159 883 26 220 tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) (AJ413948) 7.73 0.81 0.79 5.57 8.51 954 5054 334 872 406 857 818 5159 430 579 tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) (M59465) 5.3 2.61 2.11 6.31 1.35 35 1289 20 86 23 133 528 966 196 199 tumor necrosis factor (ligand) superfamily, 10 (TNFSF10) (U37518) 36.53 4.33 5.71 1.83 1.01 137 239 68 428 319 320 177 184 115 159 TNF receptor associated factor 2 (TRAF2) (U12597.1)* 1.75 6.34 1 1.04 1.39 108 341 700 686 197 481 202 243 218 169 TNF receptor associated factor 1 (TRAF1) (U19261.1)* 3.17 0.98 2.44 1.2 0.78 137 239 70 428 319 310 175 185 114 159 TNF receptor associated factor 6 (TRAF6) (U78798.1)* 1.75 6.14 0.97 1.06 1.39 3091 2415 1786 3028 3641 2700 5104 3364 3182 2484 TNF-receptor II (M58286) 0.78 1.69 0.74 0.66 0.78 110 3507 47 261 107 159 61 428 9 13 TNF-related apoptosis inducing ligand (TRAIL) (U37518) 31.97 5.54 1.49 7.03 1.44 774 1472 269 829 41 54 755 1198 67 59 TNF receptor 2 related protein (L04270) 1.9 3.08 1.32 1.59 0.88 548 533 200 1212 340 616 605 638 414 575 TNF-alpha converting enzyme (TACE) (U69611) 0.97 6.05 1.81 1.05 1.39 483 726 1382 496 311 337 432 398 339 430 tumor necrosis factor and lymphotoxin (M16441) 1.5 0.36 1.08 0.92 1.27 690 1124 2217 6510 1430 5173 4087 8283 3941 2530 TRAIL receptor 2 (TRAIL-R2) (AF016266) 1.63 2.94 3.62 2.03 0.64 360 387 364 232 200 147 71 40 19 81 TNF related TRAIL receptor (TRAIL-R3) (AF014794) 1.07 0.64 0.73 0.56 4.21 16 698 62 536 269 692 216 802 218 242 TNFR-related death receptor-6 (DR6) (AF068868) 43.61 8.64 2.57 3.71 1.11 1132 511 744 795 1045 703 1281 610 842 856 inhibitor of apoptosis protein (IAP-β) (U45880) 0.45 1.07 0.54 0.48 1.01 170 529 221 525 95 231 252 898 121 173 TRAF-interacting protein ( I-TRAF) (U59863.1)* 3.12 2.38 2.44 3.57 1.43 INTERLEUKINS 83 2016 703 159 81 143 240 146 116 167 interleukin 1-beta (IL-1B) (M15330) 24.44 0.23 1.76 0.61 1.44 153 3812 261 305 40 279 1281 4225 42 55 interleukin 1-alpha (IL-1A) (X62851) 24.9 1.17 6.95 3.3 1.3 718 19449 87 165 16 73 2874 18261 72 23 interleukin 8 C-terminal variant (IL-8) (M26383) 27.09 1.89 4.54 6.35 0.32 162 12947 307 186 31 472 1021 398 25 40 interleukin 8 (IL- 8) (M28130) 80.02 0.61 15.36 0.39 1.57 720 17528 105 118 127 229 1707 12463 166 113 interleukin 6 (interferon, beta 2) (IL-6) (M18403) 24.36 1.13 1.8 7.3 0.68 76 176 157 271 142 235 272 131 146 72 interleukin 15 (IL-15) (AF031167) 2.3 1.73 1.66 0.48 0.49 127 161 707 67 99 116 119 119 29 107 interleukin 10 (IL-10) (U16720) 1.27 0.1 1.17 1 3.72 154 118 614 142 113 127 114 89 120 69 interleukin 4 (IL-4) (M13982) 0.77 0.23 1.12 0.78 0.57 188 59 1135 88 148 33 85 31 183 112 interleukin 13 (IL-13) (U31120) 0.31 0.08 0.22 0.37 0.61 215 1582 371 161 200 69 477 327 971 166 interleukin 11 (IL11) (M57765) 7.36 0.43 0.34 0.68 0.17 146 750 186 242 88 221 125 355 223 198 interleukin 23 p19 subunit (SGRF) (AF031167) 5.13 1.3 2.52 2.84 0.89 55 576 28 53 25 67 128 149 212 97 small inducible cytokine A7 (chemotactic protein 3) (SCYA7) (X71087) 10.49 1.92 2.64 1.16 0.46 61 19654 12 10 22 20 36 11605 25 28 small inducible cytokine subfamily A (Cys-Cys), 20 (SCYA20) (D86955) 322.73 0.79 0.92 320.57 1.14 22 1931 14 33 15 16 68 1444 14 25 suppress. of tumorigenicity 16 (ST16) (also MAD-7, IL-24) (A1521306) 89 2..35 1.05 21.27 1.79 INTERLEUKIN RECEPTORS 66 498 124 145 60 123 181 724 194 164 interleukin 1 receptor, type I (IL-1R1) (M27492) 7.5 1.16 2.05 4 0.85 42 299 568 166 23 44 130 105 63 100 interleukin-1 receptor, type II (IL-1R2) (X59770) 7.19 0.29 1.96 0.81 1.59 75 471 18 23 29 115 28 112 17 21 soluble type II interleukin-1 receptor (U64094.1) 6.24 1.24 3.94 4.02 1.21 381 361 598 618 297 585 491 618 771 986 IL-1 receptor accessory protein (AB006537) 0.95 1.03 1.97 1.26 1.28 869 1068 1552 1823 466 333 5394 1662 238 198 interleukin 7 receptor (IL-7R) (M29696) 1.23 1.17 0.71 0.31 0.83 51 143 554 29 64 274 193 36 64 97 interleukin 10 receptor (IL-10R) (U00672) 2.81 0.05 4.31 0.18 1.5 146 172 933 103 127 17 32 185 60 92 interleukin 5 receptor (IL-5RA) (M75914) 1.17 0.11 0.13 5.74 1.54 231 253 726 237 141 64 186 212 118 150 interleukin 8 receptor type A (IL-8RBA) (U11870) 1.1 0.33 0.45 1.14 1.26 570 467 1809 465 382 448 505 426 520 442 interleukin 8 receptor type B (IL-8RB) (U11872) 0.82 0.26 1.17 0.84 0.85 313 265 772 118 128 198 158 164 211 197 interleukin 9 receptor ( IL-9R) (L39064) 0.84 0.15 1.54 1.04 0.93 183 130 742 45 194 210 70 80 122 177 interleukin 11 receptor type A ( IL-11RA) (U32324) 0.71 0.06 1.08 1.15 1.45 1479 2139 96 170 905 2199 631 1153 178 206 interleukin 13 receptor ( IL-13R) (U70981) 1.45 1.77 2.43 1.83 1.16 290 256 789 272 219 207 358 205 102 167 interleukin 15 type A receptor (IL-15RA) (U31628) 0.88 0.34 0.95 0.57 1.63 INTERLEUKIN RELATED FACTORS 590 1346 348 478 206 424 521 1221 548 453 inteleukin 1-B converting enzyme, gamma (U13698.1)* 2.28 1.37 2.06 2.34 0.83 158 480 51 232 55 110 102 341 125 167 inteleukin 1-B converting enzyme, delta 3.04 4.55 2 3.33 1.34 17 461 18 17 7 88 153 438 37 102 inteleukin 1-B converting enzyme, epsilon (U13700.1)* 27.41 0.97 12 2.85 2.75 19 504 43 58 182 216 71 32 61 86 IL-1B convertase (ICE) (M87507) 26.23 1.35 1.18 0.45 1.41 45 247 408 208 58 17 35 166 44 32 IL-1R antagonist (X52015) 5.46 0.51 0.3 4.76 0.74 550 470 149 414 402 440 361 429 353 441 IL enhancer binding factor 3 (U58198) 0.85 2.78 1.1 1.19 1.25 1204 707 1285 2647 1403 1336 2190 2954 1892 1718 interleukin-1 receptor-associated kinase 1 (IRAK) (L76191) 0.59 2.06 0.95 1.35 0.91 3055 1852 3842 5469 7083 5384 2923 1386 3116 3026 interleukin-1 receptor-associated kinase 1 (IRAK1) ( L76191.1)* 0.61 1.42 0.76 0.47 0.97 827 446 98 571 617 313 234 382 508 546 myleoid differentiation primary response protein (MyD88) (U70451) 0.54 5.81 0.51 1.63 1.08 37 7 323 3 53 12 47 5 52 27 Tollip like receptor 3( TLR3) (U88879) 0.19 0.01 0.22 0.11 0.51 889 351 577 179 369 199 298 311 308 376 TAK-1 binding protein (TAB-1) (U49928) 0.4 0.31 0.54 1.04 1.22 854 1796 1075 1198 832 551 963 911 609 602 MAP kinase kinase 3 (MKK3) (L36719) 2.1 1.11 0.66 0.95 0.99 1617 1761 1682 2383 780 1279 2648 2977 1111 1313 IkB kinase alpha subunit (IKK-alpha) (AF009225) 1.09 1.42 1.64 1.12 1.18 964 1013 1571 646 1027 898 1218 883 785 957 IkB kinase gama subunit (IKK-gama) (AF074382) 1.05 0.41 0.87 0.72 1.22 488 481 590 1179 176 343 811 1290 114 97 inhibitory kappa B epsilon (IkB-epsilon) (U91616) 0.99 2 1.95 1.59 0.85 225 247 143 183 201 335 221 180 140 183 inhibitory kappa B beta (IkB-beta) (AF031416) 1.1 1.28 1.67 0.82 1.31 5394 8622 3755 2893 1139 1413 2654 2197 879 1155 MAD-3, IkB like activ. (M69043) 1.6 0.77 1.24 0.83 1.31 23 29 44 417 166 300 657 736 53 22 NFkB inducing kinase (NIK) (Y10256) 1.24 9.43 1.81 1.12 0.41 INTERFERONS 102 416 454 16 67 74 52 44 34 59 INF-α (V00551) 4.08 0.04 1.1 0.85 1.72 172 12558 57 82 13 169 13 11 84 12 INF-β (X04430) 73.22 1.42 13.28 0.86 0.15 174 827 137 702 384 916 1073 1979 554 542 INF regulatory factor 1 (L05072) 4.75 5.12 2.39 1.84 0.98 353 163 392 277 353 368 444 403 296 262 INF regulatory factor 2 (X15949) 0.46 0.71 1.04 0.91 0.89 590 1278 463 1386 1038 573 715 1464 968 856 INF-regulatory factor 3 (Z56281) 2.17 3 0.55 2.05 0.88 355 514 394 1230 361 606 423 728 129 193 INF-regulatory factor 5 (U51127) 1.45 3.12 1.68 1.72 1.5 346 370 1556 229 324 325 471 245 337 262 INF-regulatory factor 6 (AL022398) 1.07 0.15 1 0.52 0.78 337 556 160 276 4 298 170 431 323 192 INF-regulatory factor 7 (NM_004030.1)* 1.65 1.73 69.3 2.53 0.59 347 530 98 287 981 1604 411 365 290 747 INF-γ Receptor alpha chain (U19247) 1.53 2.94 1.63 0.89 2.57 2892 5916 816 1032 1041 1211 3001 3661 1333 1809 INF-γ Receptor 2 (BC003624.1)* 2.05 1.26 1.16 1.22 1.36 826 1366 1046 890 581 588 652 1051 784 739 INF-γ Receptor 1 (BC005333.1)* 1.66 0.85 1.01 1.61 0.94 201 730 921 166 225 141 169 148 202 254 INF-γ-induc. indoleamine-dioxygenase (IDO) (M34455) 3.64 0.18 0.63 0.88 1.26 1176 2441 2267 1462 665 957 972 847 791 1308 INF-γ inducible protein (IP-30) (J03909) 2.08 0.64 1.44 0.87 1.65 1177 1898 716 1489 1322 1203 1581 1338 1889 999 INF-γ IEF SSP 5111 (L07633) 1.61 2.08 0.91 0.85 0.53 54 419 8 45 28 36 107 162 57 30 interferon stimulated T-cell alpha chemoatractant (AF03051.1)* 7.83 5.54 1.29 1.52 0.54 1451 3052 1565 2621 2239 2177 947 1271 599 574 interferon induced transmembrane protein 2 (1-8D) (NM_006435.1)* 2.1 1.67 0.97 1.34 0.96 738 1128 457 351 275 331 183 288 639 1018 interferon stimulated transcroption factor 3 (ISGF3) (M87503.1)* 1.53 0.77 1.21 1.58 1.59 734 5032 334 924 508 524 929 4152 753 972 interferon-stimulated protein, 15 kDa (ISG15) (U96014) 6.86 2.76 1.03 4.47 1.29 1122 997 418 984 709 1183 1184 1049 1499 937 INF-γ− induced protein (IFI 16) (M63838) 0.89 2.35 1.67 0.89 0.62 669 1246 574 1138 738 1026 707 492 492 765 INF-γ−inducible protein (IP-30) (J03909) 1.86 1.98 1.39 0.7 1.56 2409 9377 720 167 1566 1160 202 154 2448 1850 INF-γ- treatment inducible mRNA (M26683) 3.89 0.23 0.74 0.76 0.76 2356 1950 192 602 1389 1594 1492 1663 867 703 INF-γ -receptor accessory factor-1 (AF-1) (U05875) 0.83 3.13 1.15 1.11 0.81 1464 2331 1250 879 3256 1527 1294 1012 1324 1100 INF-induced 17-kDa/15-kDa protein (M13755) 1.59 0.7 0.47 0.78 0.83 424 483 312 240 425 526 775 45 285 402 INF-inducible peptide (U22970) 1.14 0.77 1.24 0.06 1.41 3870 8019 16378 6002 4699 9083 9444 3635 4545 6636 INF-inducible protein kinase (PKR) (U50648) 2.07 0.37 1.93 0.38 1.46 549 643 649 2545 665 2094 1091 1451 972 1774 INF-related developmental regulator (FRD1) (Y10313) 1.17 3.92 3.15 1.33 1.83 5096 5015 3176 9638 4338 1284 20099 18607 891 689 INF-inducible protein 9-27 (J04164) 0.98 3.03 0.3 0.93 0.77 3076 2260 4596 5709 1270 1107 15311 12900 354 50 INF-inducible gene family 1-8U (X57352) 0.73 1.24 0.87 0.84 0.14 963 882 1655 835 384 41 1498 2506 160 58 INF-inducible gene family 1-8D (X57351) 0.92 0.5 0.11 1.67 0.36 166 98 168 107 359 144 127 109 134 206 INF-inducible 56 Kd protein (M24594) 0.59 0.64 0.4 0.86 1.54 91 251 192 781 1243 310 476 934 1170 1498 growth-arrest-specific protein (GAS) (L13720) 2.76 4.08 0.25 1.96 1.28 TRANSCRIPTION FACTORS 441 1242 84 1270 213 28 847 1352 61 170 p50-NF-kappa B (S76638) 2.81 15.19 0.13 1.6 2.79 1048 1219 495 1870 1147 1592 1465 2215 1342 1370 NF-kappa-B transcription factor p65 subunit (L19067) 1.16 3.78 1.39 1.51 1.02 2565 1977 2165 2065 1249 1066 2349 2293 1271 999 NF-kappa-B DNA binding subunit (NF-kappa-B) (M58603) 0.77 0.95 0.85 0.98 0.79 933 825 2478 711 842 981 802 870 1137 818 R kappa B (X80878) 0.88 0.29 1.16 1.08 0.72 7534 8710 6054 9820 3824 6553 8112 9874 6880 9646 JUN-D (X56681) 1.16 1.62 1.71 1.22 1.4 957 3865 384 1593 732 814 495 1902 529 762 JUN-B (X51345) 4.04 4.15 1.11 3.84 1.44 134 524 40 275 345 276 579 465 503 307 c-JUN proto oncogene (J04111) 3.91 6.87 0.8 0.8 0.61 2032 2534 49 964 590 241 631 205 414 415 transactivator (JUN-B) (M29039) 1.25 19.71 0.41 0.32 1 21110 20502 4968 14570 14776 23270 12670 10372 11835 16717 v-fos transformation effector (FTE-1) (M84711) 0.97 2.93 1.57 0.82 1.41 2059 1060 230 76 667 131 125 51 439 345 c-FOS (K00650) 0.51 0.33 0.2 0.41 0.79 519 833 1453 1143 597 832 1162 1100 762 631 FRA-1 (X16707) 1.6 0.79 1.39 0.95 0.83 1045 1405 1177 3698 1335 3019 1613 3141 2863 3247 BTG-1 (X61123) 1.34 3.14 2.26 1.95 1.13 549 643 649 2545 665 2094 1091 1451 972 1774 PC4, interferon related developmental regulator (Y10313) 1.17 3.92 3.15 1.33 1.83 176 86 127 61 33 40 110 67 140 72 TFIIH (Y07595) 0.49 0.48 1.2 0.6 0.51 1512 1842 912 1869 638 923 1373 1678 768 660 ERK (X80692) 1.22 2.05 1.45 1.22 0.86 203 100 89 203 177 172 228 65 300 276 p300 nuclear signal intergrator (U01877) 0.49 2.28 0.98 0.28 0.92 360 291 660 263 283 552 319 635 316 470 CREB transactivator protein (M27691) 0.81 0.4 1.95 1.99 1.49 130 158 92 230 161 182 234 184 337 331 CBP, CREB binding protein (U47741) 1.21 2.5 1.13 0.78 0.98 554 618 1143 680 584 642 766 500 516 698 ELK-1 (AB016194) 1.12 0.59 1.1 0.65 1.35 272 329 41 426 321 374 255 202 338 356 ELK-3 (NM_005230.1)* 1.21 10.33 1.16 0.79 1.05 951 987 376 626 701 848 702 631 565 587 ERCC3 excision repair cross complementing helicase activity (M31899) 1.04 1.66 1.21 0.9 1.04 1037 1349 255 930 1392 905 1211 790 930 968 plasminogen activator inhibitor 1 (PAI-1) (J03764) 1.3 3.64 0.65 0.65 1.04 116 765 643 110 20 19 35 24 76 121 plasminogen activator inhibitor 1 (PAI-2) (Y00630) 6.61 0.17 0.97 0.69 1.59 754 1880 658 2922 2472 1794 5005 2874 1573 678 beta-migrating plasminogen activator inhibitor (M14083) 2.5 4.44 0.73 0.57 0.43 3245 6278 3352 12213 3388 7377 5570 13583 7019 8552 transcription factor NF-IL6 (C/EBPbeta) (X52560) 1.93 3.64 2.18 2.44 1.22 879 706 705 2267 212 1191 1154 1241 856 1045 C/EBP gama (U20240) 0.8 3.22 5.62 1.07 1.22 3909 2745 1849 3304 2714 2870 2820 2374 3223 2400 E2F-4 transcription factor (S75174) 0.7 1.79 1.06 0.84 0.74

KINASES 362 351 1155 1267 223 250 253 232 297 240 p38 activated protein kinase (MAPK) (L35253) 0.97 1.1 1.12 0.92 0.81 345 330 858 27 102 19 51 112 64 40 (PKC) (X07109) 0.96 0.03 0.18 2.2 0.62 1439 1620 295 1743 1131 1148 1457 1492 1111 1196 protein kinase C substrate 80K-H (PRKCSH) (J03075.1)* 1.13 5.91 1.01 1.02 1.08 2138 1709 1790 1097 2473 1407 840 1068 2079 1417 mitogen-activated protein kinase kinase 2 (MAP2K2) (BC000471.1)* 0.8 0.61 0.57 1.27 0.68 389 971 324 1248 791 854 861 1554 514 284 mitogen-activated protein kinase kinase 3 (MAP2K3) (NM_002756)* 2.5 3.86 1.08 1.81 0.55 688 490 347 355 319 380 490 355 602 510 mitogen-activated protein kinase 1 (MAPK1) (NM_002745.1)* 0.71 1.03 1.19 0.73 0.85 OTHER 1408 1816 3931 590 625 707 779 581 675 506 membrane-type matrix metalloproteinase 1 (Z48481) 1.29 0.15 1.13 0.75 0.75 3578 4968 97 2976 8671 6229 3919 8575 3054 3794 tissue inhibitor of metalloproteinases (TIMP) (D11139) 1.39 30.84 0.72 2.19 1.24 662 571 2464 320 357 573 294 446 955 959 (M95678) 0.86 0.13 1.6 1.52 1 166 735 258 178 10 237 230 556 22 336 inositol 1,4,5-trisphosphate receptor type 1 (D26070) 4.44 0.69 23 2.41 15.62 903 668 598 442 512 514 504 289 706 521 K-ras (M54968) 0.74 0.74 1.01 0.57 0.74 841 1121 204 1184 1531 876 701 433 2482 1871 hypoxia-inducible factor 1 alpha (HIF-1 alpha) (U22431) 1.33 5.8 0.57 0.62 0.75 2374 1836 2172 607 2938 2081 1114 796 4278 3445 ESP-1 separatin (D42123) 0.77 0.28 0.71 0.71 0.81 233 227 469 540 389 417 139 282 467 421 zinc-finger protein (Bcl-6) (U00115) 0.97 1.15 1.07 2.03 0.9 541 397 912 360 474 489 516 354 415 610 ERCC3 excision repair cross complementing helicase activity (X52221) 0.73 0.39 1.03 0.69 1.47 1714 1254 3576 1208 1370 1382 1161 1720 2261 1520 topoisomerase I (J03250.1)* 0.73 0.34 1.01 1.48 0.67 2002 1033 386 106 1810 189 349 128 487 49 DNA topoisomerase II (top2) (J04088) 0.52 0.28 0.1 0.37 0.1 722 471 204 418 387 394 486 333 343 256 topoisomerase III (U43431) 0.65 2.05 1.02 0.69 0.75 601 467 748 103 756 306 490 258 222 192 DNA polymerase alpha (L24559) 0.78 0.14 0.4 0.53 0.87 1161 5415 1374 5264 1474 6224 1343 9419 1001 1171 methionine adenosyltransferase II, alpha, (BC001854) 4.66 3.83 4.22 7.01 1.17 631 569 210 42 454 70 199 72 60 93 dihydrofolate reductase (J00140) 0.9 0.2 0.15 0.36 1.56 2102 1285 234 457 2372 613 1194 900 484 256 thymidine kinase (K02581) 0.61 1.95 0.26 0.75 0.53 158 802 1676 5373 7539 4760 5144 11743 1053 3089 Adrenomedullin (D14874) 5.07 3.2 0.63 2.28 2.93 1459 766 2244 1180 1741 1128 1076 766 2285 2690 microtubule-associated protein 4 (MAP-4) (M64571) 0.52 0.53 0.65 0.71 1.18 700 399 670 641 860 374 1215 668 691 434 phosphoprotein p18 (stathmin) (J04991.1)* 0.57 0.96 0.43 0.55 0.63 7303 6288 4170 5828 7375 9058 8021 7743 6820 6425 14-3-3 eta (U43999.1)* 0.86 1.4 1.23 0.97 0.94 2978 3085 149 1088 1854 1403 679 1554 2228 2488 14-3-3 epsilon (U43399.1)* 1.04 7.3 0.76 2.29 1.12 2478 3975 875 1414 2107 1999 2057 1938 1330 952 14-3-3 sigma (U28964.1) 1.6 1.62 0.95 0.94 0.72 865 1785 1151.6 1737.6 1398 2256.2 780 920 2357.8 2495.6 integrin, alpha 5 (fibronectin receptor, α) (ITGA5) NM_002205.1)* 2.06 1.51 1.61 1.18 1.06