Surgical Approaches to the Nasopharynx

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Surgical Approaches to the Nasopharynx Surgical approaches to the nasopharynx An essay submitted for fulfillment of master degree in Otorhinolaryngology Presented by Moamen Mohammed Assem Mohammed Nawwar M.B.B.Ch. Cairo University Under supervision of Prof. Dr. Sherif Adly Raafat Professor of otorhinolaryngology Faculty of Medicine Cairo University Prof. Dr. Ashraf Bahaa El-Din Fayek Professor of otorhinolaryngology Faculty of Medicine Cairo University Dr. Ahmed Hussein Abd El-Gawad Lecturer of Otorhinolaryngology Faculty of Medicine Cairo University 2012 بسم هللا الرمحن الرحمي ﴿ يرفع ا﵀ الذين ءامنوا منكم والذين أوتوا العلم درجات وا﵀ بما تعملون خبير ﴾ صدق هللا العظمي سورة المجادلة اﻵية )١١( Abstract The nasopharynx lies deep and central in the skull. It is the region located behind the nasal cavities and above the soft palate. The undersurface of the body of the sphenoid bone forms the slanting roof that merges inferiorly with the posterior wall. The floor of the nasopharynx opens downward into the oropharynx at the level of the soft palate. Tumours arising from the nasopharynx could be benign or malignant. The most common benign tumour is angiofibroma, while the main malignant neoplasm is nasopharyngeal carcinoma. Surgical excision of JNA is considered the primary treatment modality. Surgery has a limited role in the treatment of nasopharyngeal carcinoma because of the tumor's high degree of radiosensitivity and the anatomic barriers to surgical access. Resection of lesion in the nasopharynx is a challenge due to this anatomical complexity and the surrounding vital structures. Preoperative radiologic evaluation of the tumor is important in planning the surgical approach. Although it is entirely accepted that surgery is the treatment of choice for the majority of JNAs, the surgical approach is still under discussion. Several open surgical approaches have been performed. Each approach has its advantages and disadvantages. Key Words : Epstein-Barr virus - Eustachian tube - EBV encoded early RNA . Acknowledgment Thanks to ALLAH for giving me the power and strength to carry out this work. Words stands short when they come to express my gratefulness to my supervisors. I wish to express my sincere gratitude and thanks to Prof. Dr. Sherif Adly Raafat, for his remarkable effort, considerable help and continuous guidance which were the major factors behind the completion of this work. My deep gratitude goes to his faithful supervision and great cooperation. I am deeply indebted to Prof. Dr. Ashraf Bahaa El-Din Fayek, for his patience and keen supervision. He generously offered me agreat help through his experience, support and encouragement. My deep gratitude goes to Dr. Ahmed Hussein Abd El-Gawad, for his constant support valuable advice and remarks that have been of utmost help. Lastly, I wish to express my sincere gratitude to my family, dear professors and colleagues for their help, encouragement and support. i Contents Title Page Acknowledgement ………………………………...…………………… i List of Figures ……………………………………………………… ii List of Tables ……………………………………………………… vi List of Abbreviations ……………………………………………………... vii Introduction ……..…………………….………………………… 1 Chapter (1) Anatomy of the nasopharynx ……………………. 3 Chapter (2) Lesions of the nasopharynx ……………………… 23 Chapter (3) Open surgical approaches ………………….…….. 47 Chapter (4) Endoscopic surgical approaches …………………. 72 Summary ……………………………………………………… 102 References ……………………………………………………… 104 Arabic summary List of Figures Figure title Page Figure (1) Sagittal section of the head showing the nasopharynx, nasal cavity and paranasal sinuses ………………………………….. 4 Figure (2) Axial view of pharyngobasilar fascia at two levels …………... 5 Figure (3) Axial view of the nasopharynx showing fascial spaces ……… 7 Figure (4) Axial view of the nasopharynx showing its relationship with the surrounding structures ……………………………………. 10 Figure (5) Inferior view of the skull base ………………………………... 13 Figure (6) Veins of the pterygoid plexus ………………………………… 15 Figure (7) Osteology of the infratemporal fossa …………………………. 17 Figure (8) Contents of the infratemporal fossa …………………………... 19 Figure (9) Osteology of the base of skull and the pterygomaxillary fossa 20 Figure (10) Osteology of the infratemporal fossa and the pterygomaxillary fossa …………………………………………………………... 22 Figure (11) Nasopharyngeal nonkeratinizing carcinoma …………………. 28 Figure (12) Nasopharyngeal nonkeratinizing carcinoma, undifferentiated subtype ………………………………………………………... 28 Figure (13) Nasopharyngeal nonkeratinizing carcinoma, differentiated subtype ………………………………………………………... 28 Figure (14) Nasopharyngeal keratinizing squamous cell carcinoma, well differentiated ………………………………………………….. 30 Figure (15) Basaloid squamous cell carcinoma of the nasopharynx ……… 30 Figure (16) Pure nasopharyngeal carcinoma-in-situ ………………………. 31 Figure (17) Nasopharyngeal papillary adenocarcinoma …………………... 32 Figure (18) Adenoid cystic carcinoma, the cribriform architecture ………. 34 Figure (19) Adenoid cystic carcinoma, the tubular form and solid form …. 34 ii Figure (20) Mucoepidermoid carcinoma of nasopharynx ………………… 35 Figure (21) Nasopharyngeal dermoid ……………………………………... 36 Figure (22) Inverted papilloma ……………………………………………. 37 Figure (23) Ectopic pituitary adenoma of the nasopharynx ………………. 38 Figure (24) Salivary gland anlage tumour ………………………………… 39 Figure (25) Nasopharyngeal angiofibroma ………………………………... 41 Figure (26) Extramedullary plasmacytoma ……………………………….. 43 Figure (27) Two catheters inserted through the nostrils to retract the soft palate to expose the nasopharynx (Transpalatal Approach) ….. 50 Figure (28) Vertical incision on the palate with a small anterior transverse limb to improve the exposure (Transpalatal Approach) ……… 50 Figure (29) Transmandibular-transcervical approach …………………….. 53 Figure (30) A. Lateral rhinotomy incision. B. Lateral rhinotomy incision appearance ……………………………………………………. 54 Figure (31) Intraoperative A. and postoperative B. views of lip-splitting extension of lateral rhinotomy incision ………………………. 55 Figure (32) Tumour removal via Lefort I approach ………………………. 56 Figure (33) Lefort I Closure ………………………………………………. 56 Figure (34) Gingival-buccal and gingival-labial incisions (Midfacial Degloving Approach) ………………………………………… 59 Figure (35) Transfixion incision (Midfacial Degloving Approach) ………. 59 Figure (36) Sharp dissection (Midfacial Degloving Approach) …………... 60 Figure (37) Complete degloving (Midfacial Degloving Approach) ………. 60 Figure (38) Bipedicle incisions (Midfacial Degloving Approach) ………... 61 Figure (39) Completed flap (Midfacial Degloving Approach) ……………. 61 Figure (40) 5-0 chromic suturing technique, reapproximating the anterior edge of the bipedicle flap (A) to the vestibular skin (Midfacial Degloving Approach) ………………………………………… 61 iii Figure (41) Schematic CT image, (Maxillary Swing Approach) …………. 62 Figure (42) The maxilla is swung laterally to expose the nasopharynx (Maxillary Swing Approach) …………………………………. 65 Figure (43) After removing the tumor in the nasopharynx and the lymph node in the paranasopharyngeal space (Maxillary Swing Approach) …………………………………………………….. 65 Figure (44) Intraoperative views of the infratemporal fossa approach ……. 69 Figure (45) Axial section sinus CT of a Radkowski stage IIB JNA ………. 77 Figure (46) MRI with gadolinium of a Radkowski stage IIB JNA ……….. 78 Figure (47) Angiogram illustrating vascularity of the JNA ……………….. 79 Figure (48) JNA has been mobilized medially to identify its origin ……… 81 Figure (49) Following ligation of the pedicle and detachment of the lesion (JNA) from surrounding structures …………………………… 82 Figure (50) The anatomy of the pterygopalatine fossa following removal of the posterior wall of the maxillary sinus …………………... 83 Figure (51) Extirpation of the tumor from the pterygopalatine and infratemporal fossae ………………………………………...... 84 Figure (52) Illustration of the binostril, two-surgeon transseptal approach.. 85 Figure (53) Axial and coronal T1-weighted MRIs with gadolinium obtained 6 months after endoscopic resection of the JNA …… 86 Figure (54) Schematic representation of the operation field before and after removal of the posterior half of the nasal septum ………. 88 Figure (55) The endoscopic nasopharyngectomy procedure for rT2b nasopharyngeal carcinoma ………………………………….... 91 Figure (56) The comparison of the presurgical and postsurgical magnetic resonance imaging (MRI) images …………………………….. 92 iv Figure (57) The endoscopic nasopharyngectomy procedure for rT3 nasopharyngeal carcinoma …………………………………… 93 Figure (58) A comparison of the presurgical and postsurgical magnetic resonance imaging (MRI) images …………………………….. 94 Figure (59) Nasopharyngeal endoscopic resection (NER) type 1 ………… 96 Figure (60) Nasopharyngeal endoscopic resection (NER) type 2 ………… 97 Figure (60) Nasopharyngeal endoscopic resection (NER) type 3 ……….... 98 Figure (62) Transoral adenoidectomy using a nasal endoscopic-guided curette ………………………………………………………… 99 v List of Tables Table title Page Table (1) TNM classification of carcinomas of the nasopharynx ………. 25 Table (2) Stage Grouping ……………………………………………….. 26 Table (3) Chandler’s classification ……………………………………… 74 Table (4) Andrew’s (modified Fisch) classification …………………….. 74 Table (5) Radkowski’s modification of Sessions’ classification ……….. 74 Table (6) Revised staging system for juvenile nasopharyngeal angiofibroma ………………………………………………….. 76 vi List of Abbreviations BSCC Basaloid squamous cell carcinoma CSF Cerebrospinal fluid CT Computed tomography EBER EBV encoded early RNA EBV Epstein-Barr virus ECA External carotid artery EMP
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