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GANNET53 a Drug Strategy Targeting Stabilised Mutant P53 to Fight Metastatic Platinum-Resistant Ovarian Cancer EUROPEAN PROJECT

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GANNET53 a Drug Strategy Targeting Stabilised Mutant P53 to Fight Metastatic Platinum-Resistant Ovarian Cancer EUROPEAN PROJECT A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer GANNET53 A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer EUROPEAN PROJECT Sponsor: Medical University of Innsbruck, Austria, Department of Obstetrics and Gynecology Coordinator: Prof. Dr. Nicole Concin Figure 1: THE GANNET53 PROJECT PARTNERS ORGANISATION GROUP LEADER Nicole Concin Medical University Innsbruck, AUSTRIA Christian Marth Ignace Vergote Katholieke Universiteit Leuven, BELGIUM Jalid Sehouli Charité - Universitätsmedizin Berlin, GERMANY Ioana Braicu University Medical Centre Hamburg-Eppendorf, Barbara Schmalfeldt GERMANY Sven Mahner Medical University of Vienna, AUSTRIA Robert Zeillinger Assistance Publique – Hôpitaux de Paris, FRANCE Eric Pujade-Lauraine Hôpital européen Georges-Pompidou Hôpital Tenon Centre Anticancereux Léon Bérard, FRANCE Isabelle Ray-Coquard Barbara Schmalfeldt AGO Research GmbH, GERMANY Sven Mahner PROJECT PARTNERS Medical University Innsbruck • Katholieke Universiteit Leuven • Charité Universitätsmedizin Berlin • Medizinische Universität Wien • Universitätsklinikum Hamburg-Eppendorf • Assistance Publique-Hôpitaux de Paris • Centre Léon Bérard Lyon • AGO Research GmbH • NOGGO eV • ARCAGY GINECO • Universitätsmedizin Göttingen • xailabs GmbH • ONCOLAB Diagnostics GmbH • Kliniken Essen-Mitte • Technische Universität Dresden • Centre François Baclesse Caen • Ernst-Moritz-Arndt-Universität Greifswald • Otto-von-Guericke-Universität Magdeburg A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer Nord-Ostdeutsche Gesellschaft für Gynaek- Jalid Sehouli ologische Onkologie, GERMAN ARCAY – GINECO Eric Pujade-Lauraine Association de Recherche dans le Cancers dont Gynécologique – Groupe des Investigateurs Nationaux dans l’Etude des Cancers Ovariens, FRANCE Ute M. Moll University Hospital Goettingen – Matthias Dobbelstein Georg-August University Goettingen, GERMANY Robert Zeillinger OncoLab Diagnostics GmbH, AUSTRIA xailabs GmbH, GERMANY Salvatore Vanasco Kliniken Essen Mitte, Evang. Huyssens- Philipp Harter Stiftung/Knappschaft GmbH, GERMANY Technical University of Dresden Ulrich Canzler University Hospital Carl Gustav Carus Dresden, GERMANY Centre François Baclesse Florence Joly-Lobbedez Centre de Lutte Contre le Cancer (CLCC) de Caen, FRANCE University of Greifswald Alexander Mustea University Clinic Greifswald, GERMANY University of Magdeburg Atanas Ignatov University Clinic Magdeburg, GERMANY PROJECT PARTNERS Medical University Innsbruck • Katholieke Universiteit Leuven • Charité Universitätsmedizin Berlin • Medizinische Universität Wien • Universitätsklinikum Hamburg-Eppendorf • Assistance Publique-Hôpitaux de Paris • Centre Léon Bérard Lyon • AGO Research GmbH • NOGGO eV • ARCAGY GINECO • Universitätsmedizin Göttingen • xailabs GmbH • ONCOLAB Diagnostics GmbH • Kliniken Essen-Mitte • Technische Universität Dresden • Centre François Baclesse Caen • Ernst-Moritz-Arndt-Universität Greifswald • Otto-von-Guericke-Universität Magdeburg A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer Figure 2: THE GANNET53 RECRUITMENT STRATEGY PROJECT PARTNERS Medical University Innsbruck • Katholieke Universiteit Leuven • Charité Universitätsmedizin Berlin • Medizinische Universität Wien • Universitätsklinikum Hamburg-Eppendorf • Assistance Publique-Hôpitaux de Paris • Centre Léon Bérard Lyon • AGO Research GmbH • NOGGO eV • ARCAGY GINECO • Universitätsmedizin Göttingen • xailabs GmbH • ONCOLAB Diagnostics GmbH • Kliniken Essen-Mitte • Technische Universität Dresden • Centre François Baclesse Caen • Ernst-Moritz-Arndt-Universität Greifswald • Otto-von-Guericke-Universität Magdeburg A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer Figure 3: THE GANNET53 PHASE II STUDY DESIGN PROJECT PARTNERS Medical University Innsbruck • Katholieke Universiteit Leuven • Charité Universitätsmedizin Berlin • Medizinische Universität Wien • Universitätsklinikum Hamburg-Eppendorf • Assistance Publique-Hôpitaux de Paris • Centre Léon Bérard Lyon • AGO Research GmbH • NOGGO eV • ARCAGY GINECO • Universitätsmedizin Göttingen • xailabs GmbH • ONCOLAB Diagnostics GmbH • Kliniken Essen-Mitte • Technische Universität Dresden • Centre François Baclesse Caen • Ernst-Moritz-Arndt-Universität Greifswald • Otto-von-Guericke-Universität Magdeburg A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer Figure 4: Proximity Ligation Assay (PLA) detecting Hsp90-mutp53 interaction applied on: FFPE ovarian cancer tissue (left), and ascites of an ovarian cancer patient (right) Figure 5: Immunofluorecence staining of circulation tumour cells (CTC) from blood samples. A: Positive control of T47D cells spiked in leucocytes of a healthy donor; B: Example of a CTC detected in blood of an ovarian cancer patient. A B LEGAL NOTE: All rights to the images displayed in Figures 4 and 5 are reserved by the GANNET53 consortium PROJECT PARTNERS Medical University Innsbruck • Katholieke Universiteit Leuven • Charité Universitätsmedizin Berlin • Medizinische Universität Wien • Universitätsklinikum Hamburg-Eppendorf • Assistance Publique-Hôpitaux de Paris • Centre Léon Bérard Lyon • AGO Research GmbH • NOGGO eV • ARCAGY GINECO • Universitätsmedizin Göttingen • xailabs GmbH • ONCOLAB Diagnostics GmbH • Kliniken Essen-Mitte • Technische Universität Dresden • Centre François Baclesse Caen • Ernst-Moritz-Arndt-Universität Greifswald • Otto-von-Guericke-Universität Magdeburg .
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