DOCSLIB.ORG

Applying Regenerative Medicine to Battlefield Injuries Anthony Atala, Karen Richardson

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Applying Regenerative Medicine to Battlefield Injuries Anthony Atala, Karen Richardson Applying Regenerative Medicine to Battlefield Injuries Anthony Atala, Karen Richardson Due to advances in body armor, battlefield evacuation, clinical study of a new treatment for wounded warriors. and medical care, more US service members survive seri- Instead, there were more than 10 clinical studies of poten- ous injuries now than ever before. However, many of these tial new therapies, including trials of face transplanta- wounded warriors subsequently face daunting challenges tion, minimally invasive surgery for craniofacial injuries, overcoming severe limb, head, face, and burn wounds a lower-dose antirejection regimen for use after kidney caused by the use of improvised explosive devices. With transplantation, scar reduction treatments, fat grafting for the goal of applying the science of regenerative medicine reconstructive surgery, and new treatments for burns. to these wounds, the Department of Defense established The program’s success is due to its focus on clini- the Armed Forces Institute of Regenerative Medicine cal impact as the ultimate goal as well as the degree of (AFIRM) in 2008. collaboration among the laboratories. Now in its second Regenerative medicine is a science that takes advan- 5 years, AFIRM-II, led by the Wake Forest Institute for tage of the body’s natural healing powers to restore or Regenerative Medicine (WFIRM), includes researchers replace damaged tissues and organs. A multi-institutional, from more than 30 academic institutions and industries, interdisciplinary network of scientists, AFIRM has a mis- and it has $75 million in government support from the sion to accelerate the development of new regenerative US Army Medical Research and Materiel Command, the medicine–based products and therapies to treat severe Office of Naval Research, the Air Force Medical Service, injuries suffered by US service members. the Office of Research and Development - Department of AFIRM is a results-focused program that not only funds Veterans Affairs, the National Institutes of Health, and the scientific research but requires that discoveries be tested Office of the Assistant Secretary of Defense for Health and compared so that the most promising therapies can Affairs. With this funding, the AFIRM-II team is focusing be brought to clinical trials. Therapies that come out of on developing clinical therapies in several areas: restor- this effort can help not only our wounded warriors but also ing function to severely traumatized limbs; reconstruction patients in hospitals across North Carolina and the world. for facial and skull injuries through tissue regeneration; To date, AFIRM has exceeded the US Army’s expec- skin regeneration for burn injuries; new treatments to tations regarding the speed of translating new therapies prevent rejection of “composite” transplants such as face from the research laboratory into clinical trials. During and hands; and reconstruction of the genital and urinary the program’s first 5 years, researchers were charged organs and lower abdomen including the bladder, anal with having at least 1 patient ready to be entered into a sphincter, and external genitalia. 324 NCMJ vol. 76, no. 5 ncmedicaljournal.com AFIRM-II encompasses 60 different projects, with Johns Hopkins University; Livionex, Inc.; Massachusetts almost one-quarter of them based in North Carolina. General Hospital; Mayo Clinic; New York University School Examples of research underway at WFIRM include engi- of Medicine; Northwestern University; Oregon Health and neering blood vessels in the lab for limb reconstruction Science University; Radboud University Medical Center; and developing cell therapies to improve recovery after Research Foundation of SUNY; Rice University; Stanford compartment syndrome, a severe consequence of blast University School of Medicine; Rutgers; Southwest injuries that can result in amputation. In the area of facial Research Institute; Stratatech Corporation; The Ohio injuries, the Wake Forest team is working to engineer State University College of Medicine; Tufts University; replacement muscle tissue in the lab and is using 3D print- University of California, Los Angeles; University of ers to print facial components such as bone, cartilage, and Cincinnati; University of Connecticut; University of muscle for reconstructive surgeries. Florida; University of Louisville School of Medicine; During the first few days after a burn injury, the wound University of Maryland School of Medicine; University can expand in size and increase in severity. Over the long of Michigan; University of Pittsburgh; University of term, burn progression results in increased scarring, Washington Medicine; Vanderbilt University Medical increased contraction, and reduced function. WFIRM has Center; and Wake Forest University School of Medicine developed a skin cell printer and is evaluating the poten- (Wake Forest Baptist Medical Center). tial of using stem cells found in the amnion for enhanced Anthony Atala, MD director, Wake Forest Institute for Regenerative wound healing. Medicine, Winston–Salem, North Carolina. Another unmet need for wounded warriors is advanced Karen Richardson, BA communications manager, Wake Forest treatments for severe genitourinary and pelvic injuries Institute for Regenerative Medicine and Department of Urology, Winston–Salem, North Carolina. that occur due to improvised explosive devices. These injuries can result in permanent urinary and fecal inconti- Acknowledgments nence, loss of sexual function, infertility, the need for tes- Potential conflicts of interest. A.A. and K.R. have no relevant con- flicts of interest. tosterone replacement, and colostomy. WFIRM’s projects in this area include engineering bladder, penile, testicular, urethral, and anal sphincter tissue, as well as developing Electronically published November 13, 2015. a cell therapy to restore function to penile erectile tissue. Address correspondence to Dr. Anthony Atala, Wake Forest Baptist Members of the AFIRM-II team, known as the Warrior Medical Center, Medical Center Blvd, Winston–Salem, NC 27157 Restoration Consortium, are Brigham and Women’s ([email protected]). N C Med J. 2015;76(5):324-325. ©2015 by the North Carolina Hospital; Case Western Reserve University; Cleveland Institute of Medicine and The Duke Endowment. All rights reserved. Clinic; Georgia Institute of Technology; Jewish Hospital; 0029-2559/2015/76513 NCMJ vol. 76, no. 5 325 ncmedicaljournal.com.
Load more

Recommended publications
  • Pluripotent Stem Cells: the Search for the "Perfect" Source
    Minnesota Journal of Law, Science & Technology Volume 12 Issue 2 Article 10 2011 Pluripotent Stem Cells: The Search for the "Perfect" Source Nancy M.P. King Christine Nero Coughlin Anthony Atala Follow this and additional works at: https://scholarship.law.umn.edu/mjlst Recommended Citation Nancy M. King, Christine N. Coughlin & Anthony Atala, Pluripotent Stem Cells: The Search for the "Perfect" Source, 12 MINN. J.L. SCI. & TECH. 715 (2011). Available at: https://scholarship.law.umn.edu/mjlst/vol12/iss2/10 The Minnesota Journal of Law, Science & Technology is published by the University of Minnesota Libraries Publishing. King NMP, Coughlin CN, Atala A. Pluripotent Stem Cells: The Search for the “Perfect” Source. Minnesota Journal of Law, Science & Technology. 2011;12(2):715-30. Pluripotent Stem Cells: The Search for the “Perfect” Source Nancy M.P. King*, Christine Nero Coughlin** & Anthony Atala*** Anyone who dreamed that the public controversy over human embryonic stem cell (hESC) research had begun to die down was rudely awakened by the decision in Sherley v. Sebelius.1 On August 23, District of Columbia District Court Judge Royce Lamberth issued a preliminary injunction halting federal funding of research using newly created hESC lines until the plaintiffs’ challenge to the 2009 liberalization of funding guidelines can be heard.2 On September 9, 2010, the Court of Appeals for the District of Columbia temporarily stayed Judge Lamberth’s order,3 and on September 28, 2010, the Court of Appeals ordered that the appeal be expedited and granted the Obama administration’s motion to permit federally © 2011 Nancy M.P.
    [Show full text]
  • Scientists Prove Bioengineered Uteri Support Pregnancy 29 June 2020
    Scientists prove bioengineered uteri support pregnancy 29 June 2020 regenerative medicine and a number of the basic principles of tissue engineering and regenerative medicine were first developed at the institute. Their strategy to bioengineer functional tissues using a patient's own cells seeded onto biodegradable scaffolds has been effectively explored in preclinical studies and applied successfully in human patients to restore function in tubular and in hollow non-tubular organs. Regenerative medicine and tissue engineering technologies have emerged as an attractive option for overcoming donor organ A CT image of a bioengineered rabbit uterus with a shortages and other limitations of transplantation fetus, proving the organ supported fertilization, fetal from donors. The scientists used the same development. Credit: Wake Forest Institute for bioengineering strategy to engineer the uterus, a Regenerative Medicine (WFIRM) more complex organ with higher functional requirements involving support of embryo implantation and fetal development. In new research from the Wake Forest Institute for For this study, rabbits were randomly assigned to Regenerative Medicine (WFIRM), scientists have four groups: (1) a tissue-engineered uteri group that shown that bioengineered uteri supported received a cell-seeded scaffold using the animals' fertilization, fetal development, and live birth with own cells; (2) a non-seeded scaffold group, that normal offspring. With further development, this received a polymer scaffold only; (3) a subtotal approach may someday provide a regenerative uterine excision-only control group, where the medicine solution for women with the inability to subtotal excision was repaired by suturing and (4) a get pregnant due to uterine dysfunctional infertility normal control group, where animals underwent a sham laparotomy.
    [Show full text]
  • Uehling Lectures
    2009 U Nonprofit Organization US Postage PAID Madison, Wisconsin EHLING Permit No. 658 OCPD in Medicine and Public Health 2701 International Lane, #208 Madison, WI 53704-3126 alem, NC alem, S Winston- chool of Medicine of chool S niversity U Foreset Wake and Public Health Health Public and Continuing Professional Development in Medicine Medicine in Development Professional Continuing egenerative Medicine egenerative R for Institute Director, Public Health, Department of Urology, and Office of of Office and Urology, of Department Health, Public rology rology U of Department Chairman, & Professor chool of Medicine and and Medicine of chool S Wisconsin of niversity U Anthony Atala, MD Atala, Anthony : Y B D RE O S SPON tephen Y. Nakada, MD Nakada, Y. tephen S R: O T C RE I D URSE O C , W , M ISCONSIN ADISON E E CATION U D TIVE U XEC C F OR F ENTER NO U L 6, 2009 6, N , F L U 2009 OVEMBER RIDAY RER U ECT EHLING L ECT 2009 UEHLING LECT U RES State of the Art Regenerative Dr. David T. Uehling was born and raised outside Chicago, and completed his urology training at Northwestern. Following a Medicine successful stint as a fellow at Chicago Children's Memorial Hospital, he joined the and staff at the University of Wisconsin in 1965. Clinically, Dr. Uehling developed a statewide Update in Pediatric Urology practice in pediatric urology, and has served the children of Wisconsin admirably for 40 U years. NOVEMBER 6, 2009 Throughout his career, Dr. Uehling distinguished himself in research, with FL U NO CENTER FOR EXEC U TIVE ED U CATION REScontinuous NIH funding in the treatment of urinary tract infections.
    [Show full text]
  • Anthony Atala, M.D
    Regenerative Cell Therapies: Making Safe and Effective Treatments Available to Patients Anthony Atala, M.D. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Dr. Atala is Editor-in-Chief of three journals, including Stem Cells Translational Medicine, and Bioprinting. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society; the World Technology Award in Health and Medicine, for achieving significant and lasting progress; the Edison Science/Medical Award for innovation; the Smithsonian Ingenuity Award; the R&D Innovator of the Year Award, and the Fast Company World Changing Ideas Award for Bioprinting Tissue and Organs. Dr. Atala’s work was listed twice as Time Magazine’s top 5 medical breakthroughs of the year, and once as one of 5 discoveries that will change the future of organ transplants. He was named by Scientific American as one of the world’s most influential people in biotechnology, by U.S. News & World Report as one of 14 Pioneers of Medical Progress in the 21st Century, by Life Sciences Intellectual Property Review as one of the top key influencers in the life sciences intellectual property arena, and by Nature Biotechnology as one of the top 10 translational researchers in the world.
    [Show full text]
  • Fall '06 Vol. I, Issue IV
    InterLink: Fall 2006 Volume I, Issue IV Letter from the Editor In This Issue … Dear Colleagues and Friends, Letter from the Editor Continental Council Updates from Chairs: I hope that you had a peaceful und relaxing holiday season AP: Hai Bang Lee, PhD 2-3 and started the New Year with full vigor and energy. EU: Ivan Martin, PhD 4 NA: Anthony Atala, MD 5-7 As we all know, tissue engineering corresponds to the confluence of a multifaceted display of pre-existing disciplines Features on Tissue Engineering Laboratories: from three quite different domains: namely clinical medicine, AP: Kyoto University 7-14 engineering, and science. The ultimate goal for tissue EU: Imperial College London 14-19 engineers should be to move their research into the clinical NA: University of California-San Diego 19-26 domain, and are best understood as specific examples of general problem-solving strategies employed by surgeons and SYIS: Student & Young Investigator Section 27 physicians. For example, orthopedic surgeons have been investigating many different kinds of implants that may promote Sponsors 27 bone regeneration. From a clinical perspective, what matters is not so much as whether the active agent in a scaffold or Upcoming TERMIS Meetings 28 matrix consists of stem cells, bone morphogenetic proteins, or gene therapy vectors, but whether it is therapeutically effective. Membership Definition/Benefits 29 Similarly, nephrologists may view the dialysis machine, as a tissue engineered "artificial kidney" or a functional, Online Access to Tissue Engineering 30 biocompatible micro renal support device created via nuclear Online Journal Package 30 transplantation as possibilities along a seamless spectrum of therapeutic options rather than in terms of the radically Encourage Institutional Subscriptions 30 different underlying definitions or technologies they represent.
    [Show full text]
  • Top 50 Most Influential People on Stem Cells Today Terrapinn.Com/ TOP 50 Stem Cell Influencers Terrapinn.Com/Loyaltyasia
    Top 50 most influential people on Stem Cells today terrapinn.com/ TOP 50 stem cell influencers terrapinn.com/loyaltyasia Who are the most influential people in stemcell the global stem cell and cell therapy field? This is the question we asked our blog subscribers, LinkedIn group members and anyone in our contact network to compile a comprehensive list of the Top 50 as named by you. The following 50 personalities were picked based on their career achievements whether this was groundbreaking discovery and research or innovation, funding, lifetime dedication or simply because they might have inspired others to do well. It is great to see that we have representatives from all aspects including industry, governments, philanthropy, academia and even showbiz. Thank you to everyone who has helped us compile the list and please feel free to share it with your colleagues. blogs.terrapinn.com/ TOP 50 stem cell influencers 50 49 48 terrapinn.com/loyaltyasia totalbiopharma No. 50 Paul Knoepfler Dr Catherine Prescott Michael Werner Associate Professor Owner Partner UC Davis School of Medicine Biolatris Holland and Knight Cathy brings over 20 years of experience in [email protected] Werner has more than 25 years of Dr Paul Knoepfler is an Associate Professor in research, management and business within healthcare law, lobbying, policy Cell Biology and Human Anatomy at the UC the life-science and venture capital sectors. development and regulatory experience in Davis School of Medicine, where his lab studies She is the Founder Director of Biolatris Ltd., Washington. In addition to forming the stem cells and cancer. He is also a faculty Co-founder and Director of UniverCELL Market Alliance for Regenerative Medicine and member of the UC Davis Genome Center and , Chair of the UK National Stem Cell Network serving as its Executive Director, he is also a leader of the Cancer Stem Cell Initiative at the Advisory Committee, Director of the EESCN partner at the law firm Holland & Knight, UCD Comprehensive Cancer Center.
    [Show full text]
  • 0001193125-11-216681.Pdf
    UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 14A (Rule 14a-101) PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ¨ Definitive Proxy Statement x Definitive Additional Materials ¨ Soliciting Material Pursuant to § 240.14a-12 Cryo-Cell International, Inc. (Name of Registrant as Specified in its Charter) (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant) Payment of Filing Fee (Check the appropriate box): x No fee required. ¨ Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11. (1) Title of each class of securities to which transaction applies: (2) Aggregate number of securities to which transaction applies: (3) Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined): (4) Proposed maximum aggregate value of transaction: (5) Total fee paid: ¨ Fee paid previously with preliminary materials. ¨ Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing. (1) Amount previously paid: (2) Form, Schedule or Registration Statement No.: (3) Filing Party: (4) Date Filed: Presentation to ISS Review of Performance and Shareholder Value Creation Ms.
    [Show full text]
  • Urology Update
    INSIDE Research Update 2 Prostate Cancer Diagnosis Tools 3 News Update 4 Urology BCG Blood Test Proves Beneficial5 Urology Meet Our Faculty 6 Research & Clinical Update MESSAGE FROM THE CHAIR Innovations in Urology Dear Colleagues, As we begin a new year, I am Bioengineered Tissue Constructs for Irreversibly Damaged Penile delighted to update you on Corpora the latest clinical and research Traumatic injuries in civilians and battlefield-related injuries in soldiers often news here at Wake Forest require reconstructive procedures to restore the anatomy and functionality of Baptist Health Urology. From the penis. However, these procedures are often limited by poor availability of a new clinical trial evaluating functionally intact penile tissue. Various penile reconstructive procedures, such bioengineered penile tissue as penile prostheses and autograft implantation, have been attempted. While to continued advancements in cosmetic appearance may be improved, restoration of spontaneous and natural surgical procedures, I am proud erectile function may not be achieved. This is often due to a defect of the of the innovative, pioneering corpora cavernosa, which is critical for erectile function. The concept of a tissue spirit of our faculty. engineering-based therapy has been proposed for reconstructing damaged penile corporal tissue. The clinical work of our faculty is complemented by their An upcoming clinical trial sponsored by the Armed Forces Institute for research endeavors with Regenerative Medicine (AFIRM II) has been designed to evaluate the safety of medical center colleagues, autologous engineered corpora cavernosa + albuginea constructs for treatment Urology Research Laboratory of complex penile deformities. Autologous endothelial and smooth muscle cells, obtained from enrolled subjects’ corpora cavernosa biopsies, will be cultured, and the Wake Forest Institute expanded in vitro and used to seed decellularized corpora cavernosa + albuginea for Regenerative Medicine.
    [Show full text]
  • 2020 Stem Cell Research
    2 | 2021 STEM CELLS PRINT & DIGITAL MEDIA GUIDE REACH THE GLOBAL STEM CELL RESEARCH COMMUNITY About Us. Presenting a collection of premier journals Our media provide in-depth coverageon and digital publications serving the following topics: biomedical researchers in the fast-paced • Cancer Stem Cells area of stem cells and regenerative • Stem Cell Culture • Cell-Based Drug medicine. Included are two leading journals Development, Screening, and devoted to publishing peer-reviewed articles, Toxicology web-based platforms for up-to-the minute • Cell Expansion • Embryonic Stem Cells/ developments, and email outreach for timely Induced Pluripotent Stem (iPS) Cells updates delivered directly to key opinion • Enabling Technologies for Cell-Based Clinical leader’s inboxes. Translation • Fetal and Neonatal Stem Cells 6.022 3,000 Stem Cells 2019 IMPACT AVG. CIRCULATION PRINT ONLINE • Manufacturing FACTOR 100% PAID Advances and Techniques Stem Cells Translational 6.429 18,610 • RegenerativeMedicine Medicine 2019 IMPACT UNIQUE VISITORS PER • Standards, Policies, Protocols, and ONLINE JOUNRAL FACTOR MONTH Regulations for Cell- Based Therapies Stem Cells E-Blasts • Tissue Engineering and 15-20% 12,225 RegenerativeMedicine EMAIL SPONSORSHIP AVERAGE OPEN OPT-IN DISTRIBUTION • Tissue-Specific RATE Progenitor and Stem Cells Regenerative 26.5% 12,225 • Translational Medicine Weekly and Clinical AVERAGE OPEN WEEKLY Research E-NEWSLETTER RATE DISTRIBUTION • Gene and Cell Therapy • Immuno-Therapy • Immuno-Oncology 2021 STEM CELLS PRINT & DIGITAL MEDIA GUIDE | 3 THE PRIMARY PUBLICATION FOR THE FIELD Stem Cells The premier publication venue for the most impactful research in the field, Stem Cells provides prompt, peer-reviewed publication of original research and concise reviews. Read and written by researchers whose expertise encompasses all aspects of stem cell biology, the journal covers everything from basic Editor-in-Chief: Jan A.
    [Show full text]
  • Scientists See Potential in Amniotic Stem Cells - Washingtonpost.Com Pagina 1 Van 2
    Scientists See Potential In Amniotic Stem Cells - washingtonpost.com pagina 1 van 2 Scientists See Potential In Amniotic Stem Cells They Are Highly Versatile And Readily Available By Rick Weiss Washington Post Staff Writer Monday, January 8, 2007; A01 A type of cell that floats freely in the amniotic fluid of pregnant women has been found to have many of the same traits as embryonic stem cells, including an ability to grow into brain, muscle and other tissues that could be used to treat a variety of diseases, scientists reported yesterday. The cells, shed by the developing fetus and easily retrieved during routine prenatal testing, are easier to maintain in laboratory dishes than embryonic stem cells -- the highly versatile cells that come from destroyed human embryos and are at the center of a heated congressional debate that will resume this week. Moreover, because the cells are a genetic match to the developing fetus, tissues grown from them in the laboratory will not be rejected if they are used to treat birth defects in that newborn, researchers said. Alternatively, the cells could be frozen, providing a personalized tissue bank for use later in life. The new cells are adding credence to an emerging consensus among experts that the popular distinction between embryonic and "adult" stem cells -- those isolated from adult bone marrow and other organs -- is artificial. Increasingly, it appears there is a continuum of stem cell types, ranging from the embryonic ones that can morph into virtually any kind of tissue but are difficult to tame, up to adult ones that can turn into a limited number of tissues but are relatively easy to control.
    [Show full text]
  • Anthony Atala
    PROFILE Anthony Atala becomes fibrotic. Atala’s scaffolds, of collagen and polyglycolic acid, last A single-minded focus on bringing scientific advances to patients for a few months until the bladders can survive without them. has driven Anthony Atala’s pioneering work in tissue engineering. But perhaps the most formidable problem was simply creating an organ as large and thick as a bladder, which requires extensive vascular- ization. In vitro–engineered tissues cannot generally be grown thicker Turning tissue-engineering research into biotech products is no easy task. than about 300 µm because the cells at the center lack nutrients and But Anthony Atala, director of the Wake Forest Institute for Regenerative oxygen. Atala’s solution was to enlist the body as a “terminal incubator”: Medicine, is intent on finding a way. In a recent landmark paper, his although the scaffold is formed and seeded with cells on a benchtop, group reported the first human trial of tissue-engineered bladders1. most organ growth takes place in the body, where vascularization occurs Transplantation of the artificial organs in seven young spina-bifida patients spontaneously. As Atala notes, however, this method of vascularization proved just as safe as the gold-standard treatment—surgical reconstruc- is limited to hollow organs and would not apply to solid organs like the tion using intestinal tissue—and avoided its debilitating complications. heart and liver. “The work has tremendous potential clinical benefits,” says David Atala’s clinical trial is only a first step towards made-to-order bladders. Joseph, chief of pediatric urology at the University of Alabama School of Further progress will involve refining the fabrication method, studying Medicine in Birmingham.
    [Show full text]
  • WORLD STEM CELL SUMMIT 2015 POSTER ABSTRACTS Poster Abstracts for Presentation
    WORLD STEM CELL SUMMIT 2015 POSTER ABSTRACTS Poster Abstracts for Presentation Laurel Coote Submission ID: 120105 Submission Title: Role of Viability and TNC count in the cord blood transplantation Submission Type: Poster Presentation Review Status: Accept Author(s) Ahmed Alrabai Student College of Medicine , King Khalid University , Abha , KSA Co-Author(s) Hussian Yasser Kariri - Student, College of Medicine, King Khalid University, Abha , KSA Ahmed Al-Hakami - Assistant Professor , Department of Microbiology and Parasitology, Center fo Stem Cell research, College of Medicine, King Khalid University, Abha, KSA Mohammed Eaiaz Ahmed Shariff - Assistant Professor , Department of Physiology, College of Medicine, King Khalid University, Abha, KSA Abdullah Saeed Assiri - Professor , Department of Medicine, Division of Cardiology, College of Medicine, King Khalid University, Abha, KSA Harish C Chandramoorthy - Assistant Professor , Center for Stem Cell Research, Department of Microbiology and Parasitology, College of Medicine, King Khalid University, Abha, KSA Topic Basic Research, Medicine, and Health Problem There is much literature evidence available today to support the success of cord blood hematopoietic stem cell transplantation for malignant and non-malignant diseases. Cord blood transplantations are attempted in almost all parts of the world with increasing number of cord blood banks and transplantations occurring in third world and developing countries. In many of the publications either from developed world or developing world we see that for successful cord blood transplantation, the criteria indicated includes viability and TNC numbers, however there is no uniformity in the establishment of the range and many such studies claims even low viability and cell numbers does not hinder success of the grafting and homing of stem cells.
    [Show full text]