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Sodium Iodide Spotlight 352 Compiled by Vinícius Rangel Campos Vinícius Rangel Campos Was Born in Niterói/RJ, Brazil in 1986

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Sodium Iodide Spotlight 352 Compiled by Vinícius Rangel Campos Vinícius Rangel Campos Was Born in Niterói/RJ, Brazil in 1986 1186 SPOTLIGHT SYNLETT Sodium Iodide Spotlight 352 Compiled by Vinícius Rangel Campos Vinícius Rangel Campos was born in Niterói/RJ, Brazil in 1986. He This feature focuses on a re- received his Chemistry degree from the Universidade Federal Fluminense (UFF), Niterói/RJ, Brazil in 2009. He is currently in the agent chosen by a postgradu- final stages of his MSc. studies under the supervision of Professors ate, highlighting the uses and Anna Claudia Cunha and Vitor Francisco Ferreira in Organic preparation of the reagent in Chemistry at the Universidade Federal Fluminense. His research in- current research terest is focused on the design and synthesis of new bioactive com- pounds, such as quinone and 1,2,3-triazole derivatives. Instituto de Química, Universidade Federal Fluminense, UFF, CEP: 24020-141 Niterói, Rio de Janeiro, Brazil E-mail: [email protected] Introduction NaI R–I NaX + R–X acetone Sodium iodide (NaI) occurs as colorless, odorless or as a X = Cl or Br white crystalline solid; it is slightly hygroscopic, and a commercially available reagent. It is soluble in water, Scheme 1 alcohols, acetone, and other organic solvents and stable This reaction has been expanded to include the conversion under normal temperature and pressure (mp: 651 °C, of alcohols into alkyl halides by first converting the alco- d = 3.67 g/cm3).1 On a laboratory scale, sodium iodide hol into a sulfonate ester (tosylates or mesylates are usu- may be prepared by neutralizing a solution of sodium hy- ally used), and then performing the substitution.6 Other droxide or sodium carbonate with hydriodic acid.2 Sodi- applications using sodium iodide as reagent in organic um iodide is a very useful and versatile reagent for the synthesis have been reported. They include the Finkel- synthesis of various types of organic compounds. For ex- stein rearrangement–elimination reaction of 2-chloro-1- ample, an important application of this reagent involves (chloromethyl)ethyl esters induced by NaI,7 the Diels– the conversion of an alkyl chloride or alkyl bromide to an Alder reaction between a,a,a′,a′′-tetrabromo-oxylene and alkyl iodide by the addition of sodium iodide in acetone 2-cyclopentenone in the presence of NaI,8 monoiodina- (Scheme 1).3 This nucleophilic substitution reaction, also tion of arenes by alkali metal iodide,9 transformation of known as Finkelstein reaction, may proceed via either an azides to primary amines using the CeCl3·7H2O/NaI sys- 11 SN1 or SN2 mechanism depending on the nature of the tem, and Michael addition of nucleophiles to alkenes 4,5 alkyl halide. promoted by the CeCl3·7H2O/NaI system supported on alumina.12 Abstracts I (A) Möker and Thiem showed that the 4′-chloro substituent of the 6- Cl O O O O-(4′-chlorobutyl)-1,2:3,4-di-O-isopropylidene-a-D-galactopyranose O NaI, acetone O was replaced by iodide in acetone under reflux for 24 h in a Finkel- O reflux, 24 h O ′ O stein reaction to give the product 3-O-(4 -iodobutyl)-1,2:5,6-di-O- O O 5 O isopropylidene-a-D-glucofuranose in 85% yield. O O (B) Eras et al. reported that 0.5 equivalent of sodium iodide (NaI) in O butanone and the presence of a reducing agent like sodium thiosul- Na S O R O 2 2 3 OR This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. NaI fate induce the formation of the corresponding allyl esters 2, starting + butanone Cl from 2-chloro-1-(chloromethyl)ethyl alkyl or aryl esters 1 by the Cl 48 h Finkelstein rearrangement–elimination reaction.7 2 1 R = Me(CH ) 99%. 2 14 R = Me(CH ) 2 14 2-Naph 94% 2-Naph SYNLETT 2011, No. 8, pp 1186–1187 xx.xx.2011 Advanced online publication: 20.04.2011 DOI: 10.1055/s-0030-1259950; Art ID: V35910ST © Georg Thieme Verlag Stuttgart · New York SPOTLIGHT 1187 (C) Meyer and Hergenrother described the synthesis of 2,3-disubsti- O tuted naphthalene by Diels–Alder aromatization reaction between a,a,a′,a′′-tetrabromo o-xylene and a 2-pentanone derivative in the 8 O presence of sodium iodide in DMF. Br CHBr H 2 NaI H DMF CHBr 2 Br 69% R (D) Recently, Firouzabadi et al. reported a new environmentally R . 7H O, H O friendly catalytic method for the efficient monoiodination of arenes. NaI, CeCl 3 2 2 2 O, reflux The method is based on using sodium iodide, hydrogen peroxide H 2 (35%) and cerium(III) chloride as an effective catalyst in water un- I R = H, Me, OMe NHMe, NMe der reflux conditions. This method can also be applied easily in the O 2 syntheses of iodinated cyclic ethers and iodinated lactones from their O OH corresponding unsaturated alcohols and carboxylic acids in high O 9 . 7H O, H O NaI, CeCl 2 2 2 yield. 3 CH I 2 93% H O, r.t 2 OH I O 95% (E) A new method for the conversion of aryl, heteroaryl, and vinyl NaI (2 equiv) La = NHMe bromides into the corresponding iodides utilizing NaI, a catalyst sys- ArBr ArI CuI (5 mol%), La (10 mol%) tem comprising CuI and a 1,2- or 1,3-diamine ligand was developed dioxane, 110 °C, 22–24 h NHMe by Klapars and Buchwald. This method gives products in excellent yield.10 NaI (1.5 equiv) L = b NHMe Br CuI (5 mol%), Lb (10 mol%) I n-BuOH, 120 °C, 24 h NHMe (F) Bartoli and co-workers described a simple and efficient method NaI (9 equiv) . CeCl 7H O (1.5 equiv) 2 of converting azides into exclusively primary amines using NaI in 3 RN RNH 3 2 the presence of inexpensive CeCl3·7H2O in refluxing acetonitrile or MeCN reflux or MW under microwave-assisted irradiation.11 R = Ar, 4-MeOAr, 3-ClAr, 4-O NAr, 2 Me(CH ) 2 8 (G) Bartoli and co-workers have also reported the hetero-Michel ad- dition of nucleophilic nitrogen compounds to electron-poor alkenes . Nuc NaI, CeCl 7H O 3 2 promoted by the CeCl3·7H2O/NaI system supported on alumina un- EWG EWG R + 12 Nuc: R Al O , 35 °C, 24 h 3 der solvent-free conditions. The resulting b-amino derivatives are 2 versatile synthons for the synthesis of many nitrogen-containing biologically important compounds. References (1) Kirk, R. E.; Othmer, D. F. Encyclopedia of Chemical (7) Eras, J.; Escribà, M.; Villorbina, G.; Oromí-Farrús, M.; Technology, 2nd ed., Vol. 18; John Wiley & Sons Ltd.: New Balcells, M.; Canela, R. Tetrahedron 2009, 65, 4866. York, 1969, 485. (8) Meyer, S. T.; Hergenrother, P. J. Org. Lett. 2009, 18, 4052. This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. (2) Thorpe, J. F. Thorpe’s Dictionary of Applied Chemistry, 4th (9) Firouzabadi, H.; Iranpoor, N.; Kazemi, S.; Ghaderi, A.; ed., Vol. X; Longmans Green: London, 1950, 871. Garzan, A. Adv. Synth. Catal. 2009, 351, 1925. (3) Finkelstein, H. Ber. Dtsch. Chem. Ges. 1910, 43, 1528. (10) Klapars, A.; Buchwald, S. L. J. Am. Chem. Soc. 2002, 124, (4) Meloncelli, P. J.; Martin, A. D.; Lowary, T. L. Carbohydr. 14844. Res. 2009, 344, 1110. (11) Bartoli, G.; Di Antonio, G.; Giovannini, R.; Giuli, S.; Lanari, (5) Möker, J.; Thiem, J. Eur. J. Org. Chem. 2009, 4842. S.; Paoletti, M.; Marcantoni, E. J. Org. Chem. 2008, 73, (6) Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M. Org. Biomol. 1919. Chem. 2005, 3, 3001. (12) Bartoli, G.; Bartolacci, M.; Giuliani, A.; Marcantoni, E.; Massaccesi, M.; Torregiani, E. J. Org. Chem. 2005, 70, 169. Synlett 2011, No. 8, 1186–1187 © Thieme Stuttgart · New York.
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