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Tilak Maharashtra Vidyapeeth “Efficacy of Raktbasti in the Management of Tridoshaj Panduroga W.S.R

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Tilak Maharashtra Vidyapeeth “Efficacy of Raktbasti in the Management of Tridoshaj Panduroga W.S.R Tilak Maharashtra Vidyapeeth “Efficacy of Raktbasti in the management of Tridoshaj Panduroga W.S.R. to Thalassemia Major” Dissertation for Ayurveda Vidyavachaspati (Ph. D.) Research Scholar Dr. Atul M. Bhavsar M.D. (Ayu.) B.A.M.S. (Gold Medalist) Head of the Deptt., Panchkarma, Govt. Akhandanand Ayurved Hospital, Ahmedabad (Gujarat) Guide Lt. Vd. B.D.Nandurbarkar H.P.A. Ex. Director, I.S.M. & H. Gujarat State Spaciality Kaychikitsa Year 2013 Tilak Maharashtra Vidyapeeth Gultekdi, Pune (Maharashtra) The Late Vd. P.G. Nanal Department of Ayurveda Tilak Maharashtra Vidyapeeth CERTIFICATE This is to certify that the thesis entitled Efficacy of Raktbasti in the management of Tridoshaj Panduroga W.S.R. to Thalassemia Major which is being submitted herewith for the award of degree of Vidyavachaspati (Ph.D.) in The Late Vd. P.G. Nanal Department of Ayurveda of Tilak Maharashtra Vidyapeeth,Pune is a result of original research work completed by Shri Atul Mafatlal Bhavsar under my supervision and guidance. To the best of my knowledge and belief, the work incorporated in this thesis has not formed the basis for the award of any degree or other similar title of this or any other Vidyapeeth or examining body upon him. Research Guide Vd. B. D. Nandurbarkar Place : Date : DECLARATION I hereby declare that the thesis entitled “Efficacy of Raktbasti in the management of Tridoshaj Panduroga W.S.R. to Thalassemia Major” completed and written by me has not previously been formed as the basis for the award of any degree or other similar title upon me of this or any other Vidyapeeth or examining body. Research Student Place : Date : ACKNOWLEDGEMENT My work regarding this thesis has been completed successfully by the grace of Amba Mataji of my native Pedhamali and Lord Dhanvantari. I bow at the feet of my respected mother, by whose blessings, I have been able to complete my work without hurdles. I am extremely grateful to my respected Guruji, Late Vaidya G K Dave who inspired me to carry out this immense task and graced me with his guidance every step of the way. I sincerely thank my guide, Late Vaidya B D Nandurbarkar, who has provided his valuable guidance and knowledge throughout this process. I wish to thank Vaidya Medhavini Jani¸ Ex-director, Indian System of Medicine and Homeopathy, Gujarat who encouraged me to accomplish this work. I also thank Dr. S G Bhadaliya, Dr. D M Pandya, Dr. G K Mansuri and Dr. K R Desai Ex-Superintendants of Government Akhandanand Ayurved Hospital, Ahmedabad for their valuable support. I express my gratitude towards Dr. Abhijit Joshi, Head of the Department, PhD, The Late Vd. P.G. Nanal Department of Ayurveda, Tilak Maharashtra Vidyapeeth, Pune for his guidance and cooperation. I am extremely grateful to Shri A J Shah, Ex-DDO, Ahmedabad, for his faith in my work and immense support. I am also thankful to Dr. N P Joshi, Dr. R C Patel¸ Dr. Ramesh Rawal and Dr. Mitesh Sukhadia, who have been very supportive of me. I wish to thank the technical staff of Government Akhandanand Ayurved Hospital, Ahmedabad, Shri Shailesh Patel, Ku. U J Kinariwala and Shri Atmaram Patel for their support. I am grateful to the Superintendent of Municipal Slaughter house, Ahmedabad and staff for providing me goat blood required for this study. I offer my gratitude to Shri Mahesh Trivedi, Dr. Chaitanya Vora and Dr. Vishwas Amin of Indian Red Cross Society, Ahmedabad and Dr. Ashwin Patel, Hematooncologist and Dr. Anil Khatri for their guidance. I wish to acknowledge the immense support of Yogesh, Chirag, Praffulbhai and all nursing students without whom, this task would have been much difficult. I also thank my nephews Hetal and Chetan who helped me with the designing and computer work for the thesis. My sincere gratitude to all the patients included in this study who extended their valuable support in my work. am grateful to my father-in-law, Shri Mahendra Bhavsar and respected Shri Hiralal Shah who encouraged me and offered moral support through this journey. I will always be thankful to my wife, Dr. Alpa Bhavsar, my daughter Disha and my family who supported me in successfully accomplishing this research work. In the end, i would like to thank everyone who directly or indirectly offered support and guidance throughout my research work. Dr. Atul M Bhavsar ABSTRACT Thalassemia is the most common genetic disorder resulting from abnormality of Globin chain. It is the worldwide problem of today’s era and until now there is no solution in any medical science. The nature of the disease is genetic. To add a new concept to the disease Thalassemia (Anukta Vyadhi In Ayurveda) , an attempt has been made in this study. On the basis of Charaka’s dictum, present study has tried to reveal the etiopathogenesis of Thalassemia. Prakopana of Thalassemia is by means of the Mithyaaharavihara and Asatmyaindriyartha Samyoga of parents. Which will lead to Dushti of Doshas and Dhatus. The vitiated Beejabhagavayava of Rakta Dhatu already presents in the offspring but after manifestation of disease, excess intake of Pitta Prakopaka Ahara leads to Dushti of Tridosha but mainly dushti of Pitta. According to modern review, Thalassemia is a heterogeneous group of genetic disorders of Hb synthesis characterized by a lack or decreased synthesis of globin chain. The thalassemias are classified according to which chain of the globin molecule is affected: in α thalassemia, the production of α globin is deficient, while in β thalassemia the production of β globin is defective. Thalassemia produces a deficiency of α or β globin. The Raktabasti treatment is selected from the Charak Samhita Siddhisthana Chapter-6 in this thesis as the treatment modality for Thalassemia major. Here, we used Aja Rakta (Goat blood). Goat is the healthiest animal on earth. No other infections or viruses are detected in the goat blood. So it is very safe for use in human body. Goat blood is also available freely and in required quantity from Government or Municipal Slaughter house. Basti is a very effective treatment in Ayurveda. Practically, it is acceptable. Because of the ano-rectal route Aja Rakta dose not mix with human blood directly. So it is free of risks and complications. The present study was planned with the aims and objectives of evaluating the efficacy of Rakta basti treatment in Thalassemia Major w.s.r. Tridoshaj Pandu. Patients with signs and symptoms as per proforma were selected for clinical study from the OPD and IPD of Govt. Akhandanand Ayurved Hospital, Ahmedabad - Gujarat. Minimum 30 patients for treated and 30 patients for control group were selected with inclusive and exclusive criteria. Patients having Hb 5 gm % to 10 gm % were selected having general symptoms of the Thalassemia. Any other types of Anemia except Thalassemia Major were excluded. Diagnosis was made on the basis of Vatik, Paitik and Kaphaj clinical signs and symptoms as mentioned in Ayurvedic texts and the signs and symptoms of Thalassemia major described in modern texts. A detail proforma was prepared for the purpose. The patients were selected randomly and divided into two Groups, namely Trial & Control Group. In trial group, 30 patients were registered in this group, out of which all the patients completed the course. The Patients were administered Raktabasti in Scheduled dose. In control group, 30 patients were registered with modern medical treatment for four weeks and follow up study for three months. By observing clinical improvement in Vatik Paitik, and Kaphaj signs & symptoms among the Tridoshaj Panduroga as well as Thalassemia Major, assessment of the symptoms like Panduta, Krishna nakhtva, Swas, Sunakshikutata, Jwar, Daurbalya and Hrid dravatva. Necessary qualitative and quantitative tests were applied to the observed data. Laboratory investigations were assessed and evaluated before and after treatment. The observations were statistically analyzed and results were represented graphically. TABLE OF CONTENTS 1. Introduction......................................................................................................1 2. Coneptual Study ..............................................................................................8 - Ayurvedic Review...........................................................................9 - Modern Review.............................................................................52 3. Drug Study......................................................................................................82 4. Clinical Study..................................................................................................89 5. Results............................................................................................................136 6. Discussion......................................................................................................148 7. Summary and Conclusion............................................................................166 - Summary.....................................................................................167 - Conclusion...................................................................................179 8. Bibliography..................................................................................................181 9. Proforma INTRODUCTION 1 INDRODUCTION Generation, existence and destruction are the basic and fundamental laws of universe. In the series of these changes, newer diseases stand in front to all of us. Almighty thought about challenging changes as painful as Thalassemia towards the whole world. Thalassemia
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