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Molecular Analysis on the Possible Mechanism of Β-Naphthoflavone-Induced Hepatocarcinogenesis in Rats
J Toxicol Pathol 2007; 20: 29–37 Original Molecular Analysis on the Possible Mechanism of β-Naphthoflavone-Induced Hepatocarcinogenesis in Rats Yusuke Yokouchi1, Masako Muguruma1, Mitsuyoshi Moto1, Miwa Takahashi1, Meilan Jin1, Yusuke Kenmochi1, Taichi Kohno1, Yasuaki Dewa1, and Kunitoshi Mitsumori1 1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3–5–8 Saiwai-cho, Fuchu, Tokyo 183–8509, Japan Abstract: It has been speculated that oxidative stress is involved in the liver tumor-promoting effect of β- naphthoflavone (BNF; 5,6-benzoflavone) in rats, because of its strong induction of cytochrome P450 (CYP) 1A enzymes. In order to clarify the mechanism of liver tumor promoting effects of BNF, male F344 rats were initiated with a single intraperitoneal injection of 200 mg/kg diethylnitrosamine (DEN), and fed diet containing 2% of BNF for 6 weeks staring 2 weeks after injection. Two/third partial hepatectomy was perfomed at Week 3 after the treatment of BNF. Low-density Rat Toxicology & Drug Resistance Microarray and quantitative analyses of mRNA expressions of the selected genes using real-time reverse transcription (RT) -PCR were carried out on total RNAs extracted from the livers of F344 rats. Collected liver tissues were subjected to light microscopic examinations (hematoxylin and eosin staining), immunohistochemistries of proliferating cell nuclear antigen (PCNA), glutathione S-transferase placental form (GST-P) and CYP1A1, and Schmorl staining to identify lipofuscin. Gene expression analysis showed that 7 genes (CYP1A1, CYP1A2, CYP1B1, Gstm2 (GST mu2), Gstm3, glutathione peroxidase (Gpx)2 and NAD(P)H dehydrogenase, quinone 1(Nqo1)) were up-regulated (> 1.5 fold), and 4 genes (8-oxoguanine DNA glycosylase (Ogg1), Gpx1, peroxiredoxin (Prdx) 1 and P450 oxidoreductase (Por)) were down-regulated (< 0.67 fold) in the DEN + BNF group rats as compared with the DEN alone group. -
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Dexamethasone sodium phosphate ( 0.339 ) Melengestrol acetate ( 0.282 ) 17beta−Trenbolone ( 0.252 ) 17alpha−Estradiol ( 0.24 ) 17alpha−Hydroxyprogesterone ( 0.238 ) Triamcinolone ( 0.233 ) Zearalenone ( 0.216 ) CP−634384 ( 0.21 ) 17alpha−Ethinylestradiol ( 0.203 ) Raloxifene hydrochloride ( 0.203 ) Volinanserin ( 0.2 ) Tiratricol ( 0.197 ) trans−Retinoic acid ( 0.192 ) Chlorpromazine hydrochloride ( 0.191 ) PharmaGSID_47315 ( 0.185 ) Apigenin ( 0.183 ) Diethylstilbestrol ( 0.178 ) 4−Dodecylphenol ( 0.161 ) 2,2',6,6'−Tetrachlorobisphenol A ( 0.156 ) o,p'−DDD ( 0.155 ) Progesterone ( 0.152 ) 4−Hydroxytamoxifen ( 0.151 ) SSR150106 ( 0.149 ) Equilin ( 0.3 ) 3,5,3'−Triiodothyronine ( 0.256 ) 17−Methyltestosterone ( 0.242 ) 17beta−Estradiol ( 0.24 ) 5alpha−Dihydrotestosterone ( 0.235 ) Mifepristone ( 0.218 ) Norethindrone ( 0.214 ) Spironolactone ( 0.204 ) Farglitazar ( 0.203 ) Testosterone propionate ( 0.202 ) meso−Hexestrol ( 0.199 ) Mestranol ( 0.196 ) Estriol ( 0.191 ) 2,2',4,4'−Tetrahydroxybenzophenone ( 0.185 ) 3,3,5,5−Tetraiodothyroacetic acid ( 0.183 ) Norgestrel ( 0.181 ) Cyproterone acetate ( 0.164 ) GSK232420A ( 0.161 ) N−Dodecanoyl−N−methylglycine ( 0.155 ) Pentachloroanisole ( 0.154 ) HPTE ( 0.151 ) Biochanin A ( 0.15 ) Dehydroepiandrosterone ( 0.149 ) PharmaCode_333941 ( 0.148 ) Prednisone ( 0.146 ) Nordihydroguaiaretic acid ( 0.145 ) p,p'−DDD ( 0.144 ) Diphenhydramine hydrochloride ( 0.142 ) Forskolin ( 0.141 ) Perfluorooctanoic acid ( 0.14 ) Oleyl sarcosine ( 0.139 ) Cyclohexylphenylketone ( 0.138 ) Pirinixic acid ( 0.137 ) -
Sodium Bromate
Sodium bromate sc-251012 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Sodium bromate STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY0 HEALTH2 HAZARD INSTABILITY2 OX SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS NaBrO3, "bromic acid, sodium salt" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability 0 Toxicity 2 Body Contact 2 Min/Nil=0 Low=1 Reactivity 2 Moderate=2 High=3 Chronic 3 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 10 CANADIAN WHMIS CLASSIFICATION CAS 7789-38-0Sodium bromate C-Oxidizing Material 1 EMERGENCY OVERVIEW RISK Contact with combustible material may cause fire. Harmful if swallowed. May cause CANCER. Irritating to eyes, respiratory system and skin. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ■ Bromide poisoning causes intense vomiting so the dose is often removed. Effects include drowsiness, irritability, inco-ordination, vertigo, confusion, mania, hallucinations and coma. ■ Bromate poisoning almost always causes nausea and vomiting, usually with pain of the upper abdomen. Loss of hearing can occur, and bromates damage the kidneys. EYE ■ This material can cause eye irritation and damage in some persons. -
Chlorinated and Polycyclic Aromatic Hydrocarbons in Riverine and Estuarine Sediments from Pearl River Delta, China
Environmental Pollution 117 (2002) 457–474 www.elsevier.com/locate/envpol Chlorinated and polycyclic aromatic hydrocarbons in riverine and estuarine sediments from Pearl River Delta, China Bi-Xian Maia,*, Jia-Mo Fua, Guo-Ying Shenga, Yue-Hui Kanga, Zheng Lina, Gan Zhanga, Yu-Shuan Mina, Eddy Y. Zengb aState Key Lab Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, PO Box 1130, Guangzhou, Guangdong 510640, People’s Republic of China bSouthern California Coastal Water Research Project, 7171 Fenwick Lane, Westminster, CA 92683, USA Received 5 January 2001; accepted 3 July 2001 ‘‘Capsule’’: Sediments of the Zhujiang River and Macao Harbor have the potential to be detrimental to biological systems. Abstract Spatial distribution of chlorinated hydrocarbons [chlorinated pesticides (CPs) and polychlorinated biphenyls (PCBs)] and poly- cyclic aromatic hydrocarbons (PAHs) was measured in riverine and estuarine sediment samples from Pearl River Delta, China, collected in 1997. Concentrations of CPs of the riverine sediment samples range from 12 to 158 ng/g, dry weight, while those of PCBs range from 11 to 486 ng/g. The CPs concentrations of the estuarine sediment samples are in the range 6–1658 ng/g, while concentrations of PCBs are in the range 10–339 ng/g. Total PAH concentration ranges from 1168 to 21,329 ng/g in the riverine sediment samples, whereas the PAH concentration ranges from 323 to 14,812ng/g in the sediment samples of the Estuary. Sediment samples of the Zhujiang River and Macao harbor around the Estuary show the highest concentrations of CPs, PCBs, and PAHs. Possible factors affecting the distribution patterns are also discussed based on the usage history of the chemicals, hydrologic con- dition, and land erosion due to urbanization processes. -
Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium Fortunei
International Journal of Molecular Sciences Article Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium fortunei Chun-Hao Chang 1, Semon Wu 2, Kai-Cheng Hsu 3,4, Wei-Jan Huang 5,6 and Jih-Jung Chen 7,8,9,* 1 Institute of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; [email protected] 2 Department of Life Science, Chinese Culture University, Taipei 110, Taiwan; [email protected] 3 Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan; [email protected] 4 Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan 5 Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan; [email protected] 6 Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan 7 Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan 8 Faculty of Pharmacy, National Yang-Ming University, Taipei 112, Taiwan 9 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan * Correspondence: [email protected]; Tel.: +886-2-2826-7195; Fax: +886-2-2823-2940 Abstract: Five new compounds, eupatodibenzofuran A (1), eupatodibenzofuran B (2), 6-acetyl-8- methoxy-2,2-dimethylchroman-4-one (3), eupatofortunone (4), and eupatodithiecine (5), have been isolated from the aerial part of Eupatorium fortunei, together with 11 known compounds (6-16). -
WO 2015/025175 Al 26 February 2015 (26.02.2015) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/025175 Al 26 February 2015 (26.02.2015) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C09K 5/06 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/GB2014/052580 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 22 August 2014 (22.08.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13 15098.2 23 August 2013 (23.08.2013) GB (84) Designated States (unless otherwise indicated, for every (71) Applicant: SUNAMP LIMITED [GB/GB]; Unit 1, Satel kind of regional protection available): ARIPO (BW, GH, lite Place, Macmerry, Edinburgh EH33 1RY (GB). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: BISSELL, Andrew John; C/o SunAmp, Unit TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 1, Satellite Place, Macmerry, Edinburgh EH33 1RY (GB). -
University of Groningen Drug Metabolism in Human and Rat
University of Groningen Drug metabolism in human and rat intestine van de Kerkhof, Esther Gesina IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van de Kerkhof, E. G. (2007). Drug metabolism in human and rat intestine: an 'in vitro' approach. s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 27-09-2021 Chapter 5 Induction of drug metabolism along the rat intestinal tract EG van de Kerkhof IAM de Graaf MH de Jager GMM Groothuis In preparation Chapter 5 Abstract Induction of drug metabolizing enzymes in the intestine can result in a marked variation in the bioavailability of drugs and cause an imbalance between local toxification and detoxification. -
Time-Dependent Inhibition by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin of Skin Tumorigenesis with Polycyclic Hydrocarbons1
[CANCER RESEARCH 40. 1580-1587, May 1980] 0008-5472/80/0040-OOOOS02.00 Time-dependent Inhibition by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of Skin Tumorigenesis with Polycyclic Hydrocarbons1 J. DiGiovanni,2 D. L. Berry, G. L. Gleason, G. S. Kishore, and T. J. Slaga McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706 ¡J. D.. G. S K.J. and Biology Division, Oak Ridge National Laboratory. Oak Ridge. Tennessee 37830 ¡D.L B . G L G.. T. J. S.J ABSTRACT reactive intermediates that are capable of interacting covalently with cellular macromolecules (20). The interaction with DNA, a The effects of treating female mice with single topical doses target for activated PAH intermediates, has received consid of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at various times erable attention in recent years and is presently considered a before and after 7,12-dimethylbenz(a)anthracene (DMBA), critical event in the initiation of chemical carcinogenesip. Cur benzo(a)pyrene, 3-methylcholanthrene (MCA), and (±)-trans- rent evidence suggests that bay-region diol-epoxides may be 7/S,8«-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)- ultimate carcinogenic forms for some PAH (24). This is sup pyrene were studied. TCDD, at doses of 1 /ig/mouse, was ported by recent data concerning BaP and DMBA epoxides applied topically 3 days prior to, 5 min prior to, or 1 day after that produce a DMA-binding product similar to that isolated in the initiator. The application of TCDD 5 min prior to or 1 day vivo after treatment with the parent hydrocarbon (2, 11, 17, after initiation with DMBA, benzo(a)pyrene, or MCA had little 22, 33, 42, 48, 49). -
Safety Data Sheet Breaker J481
SDS no. J481 Version 2 Revision date 10-Aug-2017 Supersedes date 11-Sep-2015 Safety Data Sheet Breaker J481 1. Identification of the substance/preparation and of the Company/undertaking 1.1 Product identifier Product name Breaker J481 Product code J481 1.2 Relevant identified uses of the substance or mixture and uses advised against Recommended Use Used as a fracturing additive in oilfield applications Uses advised against Consumer use 1.3 Details of the supplier of the safety data sheet Supplier Schlumberger Oilfield Australia Pty Ltd ABN: 74 002 459 225 ACN: 002 459 225 256 St. Georges Terrace, Perth WA 6000 +47 5157 7424 [email protected] 1.4 Emergency Telephone Number Emergency telephone - (24 Hour) Australia +61 2801 44558, Asia Pacific +65 3158 1074, China +86 10 5100 3039, Europe +44 (0) 1235 239 670, Middle East and Africa +44 (0) 1235 239 671, New Zealand +64 9929 1483, USA 001 281 595 3518 Denmark Poison Control Hotline (DK): +45 82 12 12 12 Germany +49 69 222 25285 Netherlands National Poisons Information Center (NL): +31 30 274 88 88 (NB: this service is only available to health professionals) 2. Hazards Identification 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Health hazards Acute toxicity - Oral Category 4 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2 Germ cell mutagenicity Category 2 Carcinogenicity Category 1B Specific target organ toxicity - Single exposure Category 3 Environmental hazards Not classified _____________________________________________________________________________________________ Page 1 / 12 Breaker J481 SDS no. -
Role of Aryl Hydrocarbon Receptor in Central Nervous System Tumors: Biological and Therapeutic Implications (Review)
ONCOLOGY LETTERS 21: 460, 2021 Role of aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications (Review) MONTSERRAT ZARAGOZA‑OJEDA1,2, ELISA APATIGA‑VEGA1 and FRANCISCO ARENAS‑HUERTERO1 1Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Mexico City 06720; 2Posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, México Received January 28, 2020; Accepted January 25, 2021 DOI: 10.3892/ol.2021.12721 Abstract. Aryl hydrocarbon receptor (AHR) is a ligand‑ 6. Non‑canonical AhR pathway activated transcription factor, whose canonical pathway 7. Potential therapeutic applications of the crosstalk between mainly regulates the genes involved in xenobiotic metabolism. AhR pathway and central nervous system tumors However, it can also regulate several responses in a non‑ 8. Conclusions canonical manner, such as proliferation, differentiation, cell death and cell adhesion. AhR plays an important role in central nervous system tumors, as it can regulate several 1. Background of AhR research cellular responses via different pathways. The polymorphisms of the AHR gene have been associated with the development of The study of AhR can be discussed from two standpoints; the gliomas. In addition, the metabolism of tumor cells promotes first one reflects the reality of current times, that is, human tumor growth, particularly in tryptophan synthesis, where exposure to synthetic organic compounds and the conse‑ some metabolites, such as kynurenine, can activate the AhR quences that has on human health. During the 1970s, the pathway, triggering cell proliferation in astrocytomas, medul‑ studies of several toxicologists, biochemists and molecular loblastomas and glioblastomas. -
Severe Corrosion of Steel and Copper by Strontium Bromide In
Corrosion Science 138 (2018) 275–283 Contents lists available at ScienceDirect Corrosion Science journal homepage: www.elsevier.com/locate/corsci Severe corrosion of steel and copper by strontium bromide in T thermochemical heat storage reactors ⁎ Pierre D’Ansa, , Emilie Courbonb, Marc Frèreb, Gilbert Descyc, Tiriana Segatoa, Marc Degreza a Université Libre de Bruxelles (ULB), 4MAT Department, 50, Avenue F.D. Roosevelt, CP194/03, 1050, Brussels, Belgium b UMONS, Institut de Recherche en Energie – Laboratoire de Thermodynamique, 31 Boulevard Dolez, 7000, Mons, Belgium c BE-SOL R&D, 2 rue de la Griotte, 5580, Rochefort, Belgium ARTICLE INFO ABSTRACT Keywords: Thermochemical heat storage exploits thermal solar energy to produce sustainable residential heating, obtained A. Copper by exothermal reaction between bromides and water vapour. A protocol to test the corrosion of surrounding A. Carbon steel −1 materials is discussed in the case of SrBr2 contacting copper or steel. Corrosion depth > 1 mm y is found for B. Weight loss steel in conditions where the salt remains mostly solid, due to a reaction between SrBr2 and atmospheric CO2 B. XRD that produces HBr. Temperature and the dissolution of the salt (deliquescence) also play a key role. B. Cyclic voltammetry Potentiodynamic tests, the limitations of which are discussed, corroborate the salt degradation in the case of C. Reactor conditions steel. 1. Introduction Since the late eighties, several papers have been dedicated to the corrosion problem in the case of PCMs, with tests focused on the While electrical power storage is becoming widespread through melting process or the liquid phase [21–34], and quite often in organic applications like electrical vehicles, thermal energy storage still needs compounds [30,35,36]. -
PDF Card 3-320 [Dow Chemical Co., Midland, 1 .3805 1 006 67.83 Michigan] 1 .3672 6 300 68.58
standard X-ray Diffraction Powder Patterns ^v^iSection 10-Data for 84 Substances ^•2. — Howard E. Swanson, Howard F. McMurdie, Marlene C. Morris lliloise H. Evans, and Boris Paretzkin Assisted by Johan H. deGroot and Simon J. Carmel Institute for Materials Research -y.J National Bureau of Standards ' Washington, D.C. 20234 U.S. DEPARTMENT OF COMMERCE, Refer G. Peterson, Secretary NATIONAL BUREAU OF STANDARDS, Lawrence M. Kushner, AcUng Director, Issued November 1972 Library of Congress Catalog Card Number: 53—61386 National Bureau of Standards Monograph 25 Section 10—Data for 84 Substances Nat. Bur. Stand. (U.S.), Monogr. 25— Sec. 10,161 pages (Nov. 1972) CODEN: NBSMA6 For sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402 (Order by SD Catalog No. C13.44: 25/Sec. 10). Price $2.00 CONTENTS Page Page Introduction 1 Zinc manganese oxide (hetaerolite), ZnMn20^ 61 Experimental patterns: Zinc tin oxide, Zn2Sn04 62 Ammonium aluminum sulfate, NH^AKSO^)^ 5 Calculated patterns: Ammonium copper bromide hydrate, (NH^)2CuBr^"2H20 .. 6 Barium bromide, BaBr2 63 Ammonium iodate, NH^IOj 7 Barium iodide, Bal2 66 Ammonium iron sulfate, NH^Fe(S0^)2 8 Boron oxide, B2O3 phase 1 70 Ammonium magnesium aluminum fluoride, NH^IVIgAIFg ... 9 Calcium iron silicate hydroxide, julgoldite, Barium bromide fluoride, BaBrF 10 Ca2Fe3Si30jo(OH,0)2(OH)2 72 Barium chloride fluoride, BaCIF 11 Calcium malate hydrate, CaC4H405-2H20 76 Barium sulfate (barite), BaSO^ (revised). 12 Cesium lithium cobalt cyanide, CsLiCo(CN)g 79 Cadmium