DOCSLIB.ORG

MEMOTE for Standardized Genome-Scale Metabolic Model Testing

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
MEMOTE for Standardized Genome-Scale Metabolic Model Testing Providence St. Joseph Health Providence St. Joseph Health Digital Commons Articles, Abstracts, and Reports 3-1-2020 MEMOTE for standardized genome-scale metabolic model testing. Christian Lieven Moritz E Beber Brett G Olivier Frank T Bergmann MericFollow Athistaman and additional works at: https://digitalcommons.psjhealth.org/publications Part of the Endocrinology, Diabetes, and Metabolism Commons, and the Genetics and Genomics SeeCommons next page for additional authors Recommended Citation Lieven, Christian; Beber, Moritz E; Olivier, Brett G; Bergmann, Frank T; Ataman, Meric; Babaei, Parizad; Bartell, Jennifer A; Blank, Lars M; Chauhan, Siddharth; Correia, Kevin; Diener, Christian; Dräger, Andreas; Ebert, Birgitta E; Edirisinghe, Janaka N; Faria, José P; Feist, Adam M; Fengos, Georgios; Fleming, Ronan M T; García-Jiménez, Beatriz; Hatzimanikatis, Vassily; van Helvoirt, Wout; Henry, Christopher S; Hermjakob, Henning; Herrgård, Markus J; Kaafarani, Ali; Kim, Hyun Uk; King, Zachary; Klamt, Steffen; Klipp, Edda; Koehorst, Jasper J; König, Matthias; Lakshmanan, Meiyappan; Lee, Dong-Yup; Lee, Sang Yup; Lee, Sunjae; Lewis, Nathan E; Liu, Filipe; Ma, Hongwu; Machado, Daniel; Mahadevan, Radhakrishnan; Maia, Paulo; Mardinoglu, Adil; Medlock, Gregory L; Monk, Jonathan M; Nielsen, Jens; Nielsen, Lars Keld; Nogales, Juan; Nookaew, Intawat; Palsson, Bernhard O; Papin, Jason A; Patil, Kiran R; Poolman, Mark; Price, Nathan D; Resendis-Antonio, Osbaldo; Richelle, Anne; Rocha, Isabel; Sánchez, Benjamín J; Schaap, Peter J; Malik Sheriff, Rahuman S; Shoaie, Saeed; Sonnenschein, Nikolaus; Teusink, Bas; Vilaça, Paulo; Vik, Jon Olav; Wodke, Judith A H; Xavier, Joana C; Yuan, Qianqian; Zakhartsev, Maksim; and Zhang, Cheng, "MEMOTE for standardized genome-scale metabolic model testing." (2020). Articles, Abstracts, and Reports. 2926. https://digitalcommons.psjhealth.org/publications/2926 This Article is brought to you for free and open access by Providence St. Joseph Health Digital Commons. It has been accepted for inclusion in Articles, Abstracts, and Reports by an authorized administrator of Providence St. Joseph Health Digital Commons. For more information, please contact [email protected]. Authors Christian Lieven, Moritz E Beber, Brett G Olivier, Frank T Bergmann, Meric Ataman, Parizad Babaei, Jennifer A Bartell, Lars M Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta E Ebert, Janaka N Edirisinghe, José P Faria, Adam M Feist, Georgios Fengos, Ronan M T Fleming, Beatriz García-Jiménez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher S Henry, Henning Hermjakob, Markus J Herrgård, Ali Kaafarani, Hyun Uk Kim, Zachary King, Steffen Klamt, Edda Klipp, Jasper J Koehorst, Matthias König, Meiyappan Lakshmanan, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E Lewis, Filipe Liu, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Gregory L Medlock, Jonathan M Monk, Jens Nielsen, Lars Keld Nielsen, Juan Nogales, Intawat Nookaew, Bernhard O Palsson, Jason A Papin, Kiran R Patil, Mark Poolman, Nathan D Price, Osbaldo Resendis-Antonio, Anne Richelle, Isabel Rocha, Benjamín J Sánchez, Peter J Schaap, Rahuman S Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaça, Jon Olav Vik, Judith A H Wodke, Joana C Xavier, Qianqian Yuan, Maksim Zakhartsev, and Cheng Zhang This article is available at Providence St. Joseph Health Digital Commons: https://digitalcommons.psjhealth.org/ publications/2926 correspondence correspondence MEMOTE for standardized genome-scale metabolic model testing To the Editor — Reconstructing metabolic collaboratively develop this package, Stoichiometric inconsistency, erroneously reaction networks enables the development updating it based on user input. It has been produced energy metabolites7 and of testable hypotheses of an organism’s adopted by a wide range of constraint- permanently blocked reactions are identified metabolism under different conditions1. based modeling software and public model by MEMOTE. Errors in stoichiometries may State-of-the-art genome-scale metabolic repositories (http://cbmpy.sourceforge. result in the production of ATP or redox models (GEMs) can include thousands of net/ and refs. 10–15), and should therefore be cofactors from nothing2 and are detrimental metabolites and reactions that are assigned considered the standard for encoding GEMs. to the performance of the model when using to subcellular locations. Gene–protein– Second, we present MEMOTE flux-based analysis4. reaction (GPR) rules and annotations (/’mi:moʊt/ in international phonetic MEMOTE enables a quick comparison of using database information can add meta- alphabet notation), an open-source Python any two given models, in which individual information to GEMs. GEMs with metadata software that represents a unified approach test results are quantified and condensed to can be built using standard reconstruction to ensure the formally correct definition of calculate an overall score (Supplementary protocols2, and guidelines have been put in SBML3FBC and provides quality control and Note 1). In addition to these consensus place for tracking provenance and enabling continuous quality assurance of metabolic tests, researchers can supply experimental interoperability, but a standardized means models with tools and best practices already data from growth and gene perturbation of quality control for GEMs is lacking3. Here used in software development16,17. MEMOTE studies in a range of input formats (.csv, we report a community effort to develop a accepts stoichiometric models encoded .tsv, .xls or .xslx) in MEMOTE. To support test suite named MEMOTE (for metabolic in SBML3FBC and previous versions as reproducibility, researchers can configure model tests) to assess GEM quality. input. In addition to structural validation MEMOTE to recognize specific data types Incompatible description formats and analogous to the SBML validator18, as input to predefined experimental tests for missing annotations4 limit GEM reuse. MEMOTE benchmarks metabolic models model validation (Supplementary Note 2). Moreover, numerical errors5 and omission using consensus tests from four general There are two main workflows for of essential cofactors6 in a single biomass areas: annotation, basic tests, biomass MEMOTE (Fig. 1a and Supplementary objective function can have substantial reaction and stoichiometry. Figs. 1–3). For peer review, MEMOTE impact on the predictive performance of Annotation tests check that a model is can produce either a ‘snapshot report’ or a GEM. Failure to make checks for flux annotated according to community standards a ‘diff report’ that display MEMOTE test cycles and imbalances can render model with minimum information required in results of one single or multiple models, predictions untrustworthy7. annotation of models (MIRIAM)-compliant respectively. For model reconstruction, Every year, increasing numbers of cross-references19, that all primary identifiers MEMOTE helps users to create a version- manually curated and automatically belong to the same namespace rather than controlled repository of the model and generated GEMs are published, including being fractured across several namespaces, to activate continuous integration toward those for human and cancer tissue models8. and that components are described using building a ‘history report’ that records We believe that it is essential to optimize Systems Biology Ontology (SBO) terms20. the results of each tracked edit of the GEM reproducibility and reuse. Researchers A lack of explicit, standardized annotations model. Although a model repository can need models that are software-agnostic, complicates the use, comparison and be used offline, we encourage community with components that have standardized, extension of GEMs, and thus strongly collaboration via distributed version control database-independent identifiers. Default hampers collaboration3,4. development platforms, such as GitHub conditions and mathematically specified Basic tests check the formal correctness (https://github.com), GitLab (https://gitlab. modeling formulations must be precisely of a model and verify the presence com/) or BioModels12 (http://wwwdev.ebi. defined to allow reproduction of the original of components such as metabolites, ac.uk/biomodels/). MEMOTE is tightly model predictions. Models must produce compartments, reactions and genes. These integrated with GitHub. Models generated feasible phenotypes under various conditions. tests also check for metabolite formula and and versioned in MEMOTE can easily Finally, data used to build any model must be charge information, and GPR rules. General be uploaded to GitLab and BioModels. made available in a reusable format. quality metrics, such as the degree of Collaborative model reconstruction with A dual approach could be used to improve metabolic coverage representing the ratio of MEMOTE as benchmark can occur using all GEM reuse and reproducibility. First, we reactions and genes21, are also checked. three software platforms (Fig. 1b). advocate adoption of the latest version of the A model is tested for production of We validated MEMOTE using models Systems Biology Markup Language (SBML) biomass precursors in different conditions, from seven GEM collections (Fig. 2, level 3 flux balance constraints (SBML3FBC) for biomass consistency, for nonzero Supplementary Table 1 and Supplementary package9 as the primary description and growth rate and for direct precursors. The Methods),
Load more

Recommended publications
  • Men's All-Time World Performers-Performances Rankings
    Men’s All-Time World Performers-Performances Rankings Page 1 of 127 50 METER BACKSTROKE Top 2660 Performances 24.04** Liam Tancock, GBR 13th World Championships Rome 08-02-09 (Reaction Time: +0.60. (Note: Great Britain’s first male backstroke gold-medalist [50, 100, 200]. Tancock’s first international gold/second world- record. (Note: bronze medalist [2005, Montreal; ’07, Melbourne]) 24.07*# Camille Lacourt, FRA XXX European Championships Budapest 08-12-10 (Reaction Time: +0.74. (Nore: also clocked European-record/history’second-fastest 100 back en route to gold several days earlieir [52.11]) 24.08sf1 Tancock 13th World Championships Rome 08-01-09 (Reaction Time: +0.57) 24.23 Lacourt 16th World Championships Kazan 08-09-15 (Reaction Time: +0.68, gold medalist) 24.24a Junya Koga, JPN 13th World Championships Rome 08-02-09 (Reaction Time: +0.50. (Note: won 100 back gold in an Asian-record 52.26 clocking several days earlier.) 24.27sf2 Lacourt 16th World Championships Kazan 08-08-15 (Reaction Time: +0.69) 24.28 Koga 17th Asian Games Incheon 09-21-14 (Reaction Time: +0.52 [fastest of race]. (Note: Games record, Koga’s third-consecutive gold/record. Won @ Doha in 2K6 [25.40]; Guangzhou, 2K10 [25.08]) 24.29sf2 Koga 13th World Championships Rome 08-01-09 (Reaction Time: +0.48) 24.30sf1 Lacourt XXX European Championships Budapest 08-11-10 (Reaction Time: +0.71) 24.33* Randall Bal, USA/Stanford Eindhoven Swim Cup Eindhoven 12-05-08 (Reaction Time: +0.66) 24.34* Gerhard Zandberg, RSA/Arizona 13th World Championshps Rome 08-02-09 (Note: African record.) 24.36 Lacourt FRA Nationals/WCTs Strasbouug 03-27-11 (Note: French Open-“All Comers” record.) 24.37 Lacourt FRA Nats./Euro.
    [Show full text]
  • EUROPEAN SHORT COURSE Swimming Championships Finalists
    EUROPEAN SHORT COURSE Swimming Championships Finalists 20191 Some of the stars of the European Short Course Championships in Copenhagen- top row, left Kirill Prigoda (Russia), centre, Adam Peaty (Great Britain), right, Ruta Meilutyte (Lithuania); middle row, left, Radoslaw Kawecki (Poland), centre, Maxence Orange (France), right, Fanny Lecluyse (Belgium); bottom, left, Andri Govorov (Ukraine), centre, Sarah Koehler (Germany) and Julia Hassler (Liechtenstein), right, Matteo Rivolta (Italy) (Photos: Giorgio Scala & Andrea Staccioli, Deepbluemedia/Insidefoto) 2 European Short Course Swimming Championships Finalists Contents European Sprint Results - Men 4 European Sprint Results - Women 7 European Short Course Championship Venues 10 Short Course Results - Men 11 Short Course Results - Women 88 Short Course Results - Mixed 164 European Sprint Championships Medals Tables - by country 167 European Sprint Championships Medals Tables - by event 169 European Short Course Medals Tables - by country 172 European Short Course Medals Tables - by event 178 European Short Course Leading Medallists - all time 191 Please note that, unless stated otherwise, the photos in this book were taken at the 2017 European Short Course Championships in Copenhagen 3 European Sprints Results 1991 to 1994 This book is in two sections. The first The first European Sprints were held section deals with the European Sprint between December 6th and 8th 1991 at Championships held between 1991 and Gelsenkirchen, Germany when the city 1994; the second, with the European agreed to organise the event with only Short Course Championships from 1996 to four months notice. The first European the present time. The tables of individual Short Course Championships in Rostock medals and event medal tables at the end in 1996 saw a significant expansion with of this publication, therefore, treats them some 36 events.
    [Show full text]
  • Giorno 3. Panziera E Paltrinieri D’
    Giorno 3. Panziera e Paltrinieri d’Oro. Bianchi d’Argento. written by Redazione | 6 Dicembre 2019 Oro Panziera con record italiano. Oro Paltrinieri. Argento Bianchi con primato nazionale. RECAP FINALI Photo Giorgio Scala / Deepbluemedia / Insidefoto Sua “Maestà” Gregorio Paltrinieri Con un improvviso cambio di ritmo portato ai settecento metri il fuoriclasse carpigiano si porta in testa alla gara fino al touch finale e si riprende il trono continentale dei 1500 stile libero. (14,17.14) davanti al temibile norvegese Henrik Christiansen (14.18.15), bronzo al francese David Aubry, resta fuori dal podio l’ucraino Mykhaylo Romanchuk che a metà gara sembra addirittura rinunciare alla lotta per le medaglie. Chiude la finale in ottava posizione l’azzurro Domenico Acerenza (14.51.59). “Sono contento perchè torno a vincere un 1500 dopo tanto tempo. All’inizio ho visto l’ucraino che era partito forte e sono rimasto in galleggiamento. Poi a metà gara ho notato che ha rallentato e allora ho inziato la mia progressione per fortuna vincente. Oggi non avevo le stesse sensazioni di ieri e allora mi sono tenuto coperto, passando un po’ più calmo per poi aprire il gas. Erano passati troppi anni dalla vittoria. Non mi sentivo benissimo e allora ho cercato di non strafare e di andare in progressione. La forma è cambiata dalla batteria alla finale e quindi bisognerà lavorare perchè per fare questo tempo ho dato tutto”. Gregorio Paltrinieri (Federnuoto) Il video dei 1500 stile libero (Raisport) Podio 1500 sl uomini 1) Gregorio Paltrinieri (ITA) 14.17.14 2) Henrik Christiansen (NOR) 14.18.15 3) David Aubry (FRA) 14.25.66 8) Domenico Acerenza (ITA) 14.51.49 Photo Giorgio Scala / Deepbluemedia / Insidefoto Finalmente Margherita Panziera.
    [Show full text]
  • CHG Library Book List
    CHG Library Book List (Belgium), M. r. d. a. e. d. h. (1967). Galerie de l'Asie antérieure et de l'Iran anciens [des] Musées royaux d'art et d'histoire, Bruxelles, Musées royaux d'art et dʹhistoire, Parc du Cinquantenaire, 1967. Galerie de l'Asie antérieure et de l'Iran anciens [des] Musées royaux d'art et d'histoire by Musées royaux d'art et d'histoire (Belgium) (1967) (Director), T. P. F. H. (1968). The Metropolitan Museum of Art Bulletin: Volume XXVI, Number 5. New York: Metropolitan Museum of Art (January, 1968). The Metropolitan Museum of Art Bulletin: Volume XXVI, Number 5 by Thomas P.F. Hoving (1968) (Director), T. P. F. H. (1973). The Metropolitan Museum of Art Bulletin: Volume XXXI, Number 3. New York: Metropolitan Museum of Art (Ed.), A. B. S. (2002). Persephone. U.S.A/ Cambridge, President and Fellows of Harvard College Puritan Press, Inc. (Ed.), A. D. (2005). From Byzantium to Modern Greece: Hellenic Art in Adversity, 1453-1830. /Benaki Museum. Athens, Alexander S. Onassis Public Benefit Foundation. (Ed.), B. B. R. (2000). Christian VIII: The National Museum: Antiquities, Coins, Medals. Copenhagen, The National Museum of Denmark. (Ed.), J. I. (1999). Interviews with Ali Pacha of Joanina; in the autumn of 1812; with some particulars of Epirus, and the Albanians of the present day (Peter Oluf Brondsted). Athens, The Danish Institute at Athens. (Ed.), K. D. (1988). Antalya Museum. İstanbul, T.C. Kültür ve Turizm Bakanlığı Döner Sermaye İşletmeleri Merkez Müdürlüğü/ Ankara. (ed.), M. N. B. (Ocak- Nisan 2010). "Arkeoloji ve sanat. (Journal of Archaeology and Art): Ölümünün 100.Yıldönümünde Osman Hamdi Bey ve Kazıları." Arkeoloji Ve Sanat 133.
    [Show full text]
  • Natalie Coughlin’S Success in the January 2014 - Volume 55 - No
    MIXING UP YOUR TRAINING A YEAR IN REVIEW: 2013’s TOP SWIMMING STORIES A LOOK +INTO 2014 THE GLORY OF FOOD NATALIE COUGHLIN’S SUCCESS IN THE JANUARY 2014 - VOLUME 55 - NO. 01 KITCHEN $3.95 PHELPS CLEARS SURVIVE & FIRST HURDLE THRIVE: IN COMEBACK CRAIG DIETZ LEARN MORE AT SWIMMINGWORLD.COM AMERICA’S GOLDEN GIRL: CoughlinNatalie SPECIAL NEW YEAR OFFER: CHECK OUT PAGE 65 FOR SWIMMING WORLD’S NEW YEAR SPECIAL! JANUARY.indd 1 12/22/13 5:34 PM JANUARY.indd 2 12/22/13 5:34 PM JANUARY.indd 3 12/22/13 5:35 PM JANUARY.indd 4 12/22/13 5:35 PM JANUARY.indd 5 12/22/13 5:35 PM 029 Food, Glorious Food! by Natalie Coughlin Natalie Coughlin taught herself how 2014 to cook when she was in college...and JAN she absolutely loves it! 031 Take Home Points by Dr. G. John Mullen In a partnership with Swimming World 020 U Magazine, Swimming Science provides “Take Home Points” from in-depth 045 Q&A with Coach swimming research. Jason Turcotte ARY by Michael J. Stott FEATURES 032 Yoga for Swimmers by Steve Krojniewski 047 How They Train Gunnar 010 Swimming Stories of 2013 Yoga can help swimmers strengthen Bentz and Kylie Stewart 010 by Jason Marsteller their core, stretch the pectorals, open by Michael J. Stott the shoulders and add focus for peak 014 Lessons with the Legends: performance. 048 Survive and Thrive: Dick Hannula Finding A Way by Michael J. Stott 034 Goldminds: Swim to Win! by Shoshanna Rutemiller by Wayne Goldsmith Despite not having any arms or legs, 016 Strategic Pacing in Commitment—the decision to turn 39-year-old Craig Dietz is using his Distance Events (Part II) thoughts into actions—is the key to success in open water swimming to by Michael J.
    [Show full text]
  • Helsinki 2010
    Page: 1 Date: 18 July 2010 Time: 19:18:32 Results Total - With Points and lap times Competition name: European Junior Swimming Champ Competition place: Helsinki, Finland Organizer: LEN Referee: Chief Recorder: Event 1, 50m Breaststroke Women, Finals CR: Yuliya EFIMOVA 31.45 2007-07-18 Place Name Born Point FINA Finish Status Club 1 Lisa Fissneider 1994 898 32.20 Italy 2 Lina Rathsack 1994 883 32.37 Germany 3 Sara L Lougher 1994 874 32.48 Great Britain 4 Ana Pinho Rodrigues 1994 873 32.50 Portugal 5 Jenna Laukkanen 1995 872 32.51 Finland 6 Tjasa Vozel 1994 863 32.62 Slovenia 7 Veera Kivirinta 1995 860 32.66 Finland 8 Josephina Bartela 1994 850 32.79 Denmark 9 Laura Simon 1994 816 33.24 Germany 10 Kinga Cichowska 1994 795 33.53 Poland Event 1, 50m Breaststroke Women, Semifinals CR: Yuliya EFIMOVA 31.45 2007-07-18 Place Name Born Point FINA Finish Status Club 1 Lisa Fissneider 1994 891 32.28 Italy 2 Sara L Lougher 1994 876 32.46 Great Britain 3 Ana Pinho Rodrigues 1994 874 32.49 Portugal 4 Tjasa Vozel 1994 860 32.66 Slovenia 5 Jenna Laukkanen 1995 859 32.68 Finland 6 Veera Kivirinta 1995 852 32.76 Finland 7 Lina Rathsack 1994 849 32.80 Germany 8 Josephina Bartela 1994 848 32.82 Denmark 9 Laura Simon 1994 832 33.03 Germany 10 Kinga Cichowska 1994 811 33.30 Poland 11 Tina Meza 1994 801 33.45 Slovenia 12 Elizaveta Bazarova 1995 798 33.49 Russia 13 Fanny Deberghes 1994 786 33.66 France 14 Sofya Zhigunova 1995 773 33.84 Russia 15 Claire Polit 1995 771 33.88 France 16 Ana Radic 1994 770 33.89 Croatia 17 Malin Westman 1995 758 34.07 Sweden 18 Lina
    [Show full text]
  • Women's 1500M Free (Heat A) Final
    Women's 1500m Free (Heat A) Final 2019 TYR Pro Swim Richmond | April 13, 2019 World Record: 15:20.48 Katie Ledecky, USA, Indianapolis, USA, 5/16/2018 (28.09, 58.50, 1:29.26, 2:00.25, 2:31.11, 3:02.50, 3:33.71, 4:04.88, 4:35.86, 5:06.82, 5:37.52, 6:08.29, 6:39.28, 7:10.13, 7:40.88, 8:11.70, 8:42.52, 9:13.20, 9:43.96, 10:14.83, 10:45.43, 11:16.15, 11:47.05, 12:17.94, 12:48.62, 13:19.43, 13:50.27, 14:20.71, 14:51.26, 15:20.48) American Record: 15:20.48 Katie Ledecky, USA, Indianapolis, USA, 5/16/2018 (28.09, 58.50, 1:29.26, 2:00.25, 2:31.11, 3:02.50, 3:33.71, 4:04.88, 4:35.86, 5:06.82, 5:37.52, 6:08.29, 6:39.28, 7:10.13, 7:40.88, 8:11.70, 8:42.52, 9:13.20, 9:43.96, 10:14.83, 10:45.43, 11:16.15, 11:47.05, 12:17.94, 12:48.62, 13:19.43, 13:50.27, 14:20.71, 14:51.26, 15:20.48) U.S. Open Record: 15:20.48 Katie Ledecky, USA, Indianapolis, USA, 5/16/2018 (28.09, 58.50, 1:29.26, 2:00.25, 2:31.11, 3:02.50, 3:33.71, 4:04.88, 4:35.86, 5:06.82, 5:37.52, 6:08.29, 6:39.28, 7:10.13, 7:40.88, 8:11.70, 8:42.52, 9:13.20, 9:43.96, 10:14.83, 10:45.43, 11:16.15, 11:47.05, 12:17.94, 1 Daniella Van Den Berg National Record: 17:07.88 ARU Daniella Van Den Berg Top 10 Performers This Year (2019 Calendar Year) 2018 1.
    [Show full text]
  • SWIM MART ˉUVW H[SHULHQFH LQ DQG DURXQG WKH ZDWHU in a Structured Environment Is a Positive One
    MEET YOUR MOTIVATION > ONWARD & UPWARD INSIDE COACH PAUL GRAHAM’S SUCCESS FEBRUARY 2013 - VOLUME 54 - NO. 2 DISCOVER YOUR SOURCE OF MOTIVATION + TIPS TO STAY ON 4TRACK KATINKA ON THE LEARN THE “DO”-NUTS AND* BOLTS OF MOVE... SWIMMING THOUGHTS FROM THE FRONT LINE > DAGNY KNUTSON’S AND GEMMA SPOFFORTH’S BATTLES EVEN NATURE’S LAWS WERE MEANT TO BE BROKEN NIKE FLEX LT @V\KVU»[OH]L[VILHZJPLU[PZ[[VRUV^ [OLJVTWL[P[P]LHK]HU[HNLVM[OPZYL]VS\[PVU PULSP[LWLYMVYTHUJLZ\P[Z*YLH[LKMYVT VULWPLJLVMIVUKLKMHIYPJ[OL5PRL -SL_3;OLSWZKLZ[YV`KYHNHUKSL[Z`V\ ZSPJL[OYV\NO[OL^H[LYPUHJVTWSL[LS` Z[YLHTSPULKZ[HIPSPaPUNUVZLHTZ\P[ >P[OIVUKLKZLHTZHUKHJVTWYLZZLK MP[[VOLSWRLLW^H[LYV\[P[»Z[OLVW[PT\T VW[PVUPUSPNO[^LPNO[Z^PT[LJOUVSVN` THE ALL NEW PINK LEOPARD WING BACK THEFINALS.COM FEATURES 030 The Role of Film in Swim Training 2013 012 A Meteoric Rise by Michael J. Stott Inside by Shoshanna Rutemiller FEBRUARY In the first of two parts, Swimming Katinka Hosszu has come a long way World Magazine examines some since representing Hungary in her first history and basics about videoing Olympics as a 15-year-old in 2004. swimmers. Two more Olympic Games later—as well as becoming a multiple world 032 USSSA: The “Do”-Nuts and champion and the top female swimmer Bolts of Swimming at the recent World Cup Circuit with 39 by Tracy Laman individual gold medals—she now has her sights set on even more hardware. As learn-to-swim instructors, it is their job to make sure a child’s first 012 017 Thoughts From The Front experience in and around the water Line: Battling With in a structured environment is a Disordered Eating positive one.
    [Show full text]
  • Swimming World Biweekly on the Cover - Olivia Smoliga by Peter H
    make your move. NICK GRAINGER ARIANNA VANDERPOOL-WALLACE ROBBIE RENWICK TOM LAXTON 2015 WORLD CHAMPION 2008, 2012 OLYMPIAN 2015 WORLD CHAMPION BRITISH NATIONAL CHAMPION CHALLENGER FUSE ONYX VAPOR Fully Customizable UV Protective Diamond Flex Lightweight Textile Textile Textile Compressed Textile Versatile Fit Versatile Fit Engineered Fit Structured Fit Flexible Flexible Complete Selective Compression Compression Double Panel Double Panel Compression Compression 2016 TECHNICAL RACING SUITS #makeyourmove2016 To learn more, contact your local dealer or visit FINISinc.com ISSUE #2 OF MARCH 2016 FEATURES BIWEEKLy 006 WOMEN’S NCAA DIVISION I 028 HISTORIC SURPRISES AT U.S. OLYMPIC CHAMPIONSHIP FINALS RECAP TRIALS: JEFF FARRELL by Jason Marsteller by Annie Grevers The full recap from Atlanta as the ladies In 1960, sportswriters had dubbed Jeff Farrell “the from Georgia dazzle the home crowd. fastest swimmer in the world.” However, less than a week before the U.S. Olympic Trials, he underwent an emergency appendectomy... PUBLISHING, CIRCULATION AND 012 JACK BAUERLE, LILLY KING ACCOUNTING OFFICE HONORED BY CSCAA GILES SMITH MOVES TO 4TH IN WORLD IN by Jason Marsteller 032 www.SwimmingWorldMagazine.com The College Swimming Coaches Association of America 100 FLY AT FEDERAL WAY SECTIONALS by Jason Marsteller Chairman of the Board, President - Richard Deal (CSCAA) announced award recipients from the 2016 [email protected] NCAA Division I Women’s Swimming and Diving Phoenix’s Giles Smith crushed the Olympic Trials cut Championships. in the men’s 100-meter fly. His 52.10 shot him to fourth Publisher, CEO - Brent T. Rutemiller in the world behind only Laszlo Cseh (51.40), Michael [email protected] 013 NCAA DI CHAMPIONSHIP PHOTO GALLERY Phelps (51.94) and Zhuhao Li (51.97).
    [Show full text]
  • Supplemental Digital Content
    Supplemental Digital Content Study Protocol: Longitudinal course of depressive, anxiety and post-traumatic stress disorder symptoms after heart surgery Review question What is the longitudinal course of depressive, anxiety, and post-traumatic stress-disorder (PTSD) symptoms in cardiac patients undergoing heart surgery? Searches PubMed and Scopus, up to 07/31/2019, search key: ("implantable cardiac defibrillator" OR "cardiac operation" OR "heart surgery" OR "cardiac surgery" OR "coronary artery bypass" OR "open heart surgery" OR "valve surgery" OR “heart transplant*”) AND ((("depression" OR "depressive") AND "episode") OR "major depressive disorder" OR "anxiety" OR "PTSD" OR "post-traumatic stress disorder" OR "acute stress- reaction" OR "quality of life"). The Preferred Reporting Items for Systematic RevieWs and Meta-analyses (PRISMA) recommendations will be used to guide this meta-analysis. (1) Inclusion criteria Cohort studies measuring depressive, anxiety, or PTSD symptoms with validated psychometric tools, before and at least 1 month after heart surgery. Exclusion criteria Article type different from cohort study (interventional, revieW article, meta-analysis, editorial, conference abstract, case report). Language other than English. Publication date antecedent to 1980. Population Cardiac patients scheduled for heart surgery. Exposure Cardiac surgery, whether first time or more. Comparator Post-surgical depressive, anxiety, and PTSD symptoms, whether reported as mean scores or rates by the authors, will be compared with the pre-surgical levels in the same study population. Primary outcome Primary outcome Will be the pre-post change in depressive, anxiety, and PTSD symptoms folloWing surgery, measured as standardized effect size. Secondary Outcomes Secondary outcomes Will be: 1) the durability of mental health symptom changes; 2) the correlation betWeen baseline demographic and clinical characteristics and improvement in mental health scores.
    [Show full text]
  • ISL 2020 Team
    NY BREAKERS LA CURRENT CALI CONDORS DC TRIDENT ENERGY STANDARD IRON LONDON ROAR AQUA CENTURIONS TORONTO TITANS TOKYO FROG KINGS MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY MEN COUNTRY 1 Michael Andrew USA 1 Dylan Carter TTO 1 Townley Haas USA 1 Tristan Hollard AUS 1 Chad Le Clos RSA 1 Robert Glinta ROU 1 Adam Peaty GBR 1 Travis Mahoney AUS 1 Michael Chadwick USA 1 Daiya Seto JPN 2 Marco Koch GER 2 Felipe Silva BRA 2 Tate Jackson USA 2 Conner McHugh USA 2 Florent Manaudou FRA 2 Maxim Lobanovszkij HUN 2 Kyle Chalmers AUS 2 Fabio Scozzoli ITA 2 Mack Darragh CAN 2 Shinri Shioura JPN 3 Chris Reid RSA 3 Fernando Scheffer BRA 3 Kacper Majchrzak POL 3 Matheus Santana BRA 3 Max Litchfield GBR 3 Kristof Milak HUN 3 James Guy GBR 3 Sebastian Szabo HUN 3 Sergey Fesikov RUS 3 Markus Thormeyer CAN 4 Brendon Smith AUS 4 Kristian Gkolomeev GRE 4 Radoslaw Kawecki POL 4 Zach Apple USA 4 Andrius Sidlauskas LTU 4 Ross Murdoch GBR 4 Tom Dean GBR 4 Alessandro Miressi ITA 4 Andriy Govorov UKR 4 Vlad Morozov RUS 5 Brandon Almeida BRA 5 Andrew Seliskar USA 5 Mark Szaranek GBR 5 Zach Harting USA 5 Evgeny Rylov RUS 5 Yakov Toumarkin ISR 5 Elijah Winnington AUS 5 Matteo Rivolta ITA 5 Brent Hayden CAN 5 Yasuhiro Koseki JPN 6 Felix Aubock AUT 6 Santiago Grassi ARG 6 Clyde Lewis AUS 6 Zane Grothe USA 6 Felipe Lima BRA 6 Guilherme Basseto BRA 6 Alex Graham AUS 6 Nicolo Martinenghi ITA 6 Yuri Kisil CAN 6 Katsuhiro Matsumoto JPN 7 Jack McLoughlin AUS 7 Tom Shields USA 7 Justin Ress USA 7 Robert Howard USA
    [Show full text]
  • Giorno 5. ORO Quadarella, Miressi, Di Liddo E Veloce Femminile D’
    Giorno 5. ORO Quadarella, Miressi, Di Liddo e veloce femminile d’argento, Carraro di bronzo written by Redazione | 8 Dicembre 2019 Con la quinta giornata di gare si conclude a Glasgow la ventesima edizione dei Campionati Europei di nuoto in vasca corta. Dalla giornata odierna arrivano per noi altre soddisfazioni, 1 Oro, 3 Argenti, 1 Bronzo, 3 nuovi primati nazionali e 2 medaglie di legno. Segue il recap della quinta giornata di gare. RECAP FINALI DELL’ULTIMA GIORNATA Photo Giorgio Scala / Deepbluemedia / Insidefoto Doppietta d’oro continentale per la nostra campionessa del mondoSimona Quadarella , la romana conquista il titolo europeo dei 400 stile libero dopo aver vinto quello sulla doppia distanza ad inizio rassegna. L’atleta diChristian Minotti dimostra una volta ancora la straordinaria capacità di leggere ed interpretare la gara con una percezione delle avversarie fuori dal comune, il poderoso cambio di ritmo imposto dall’azzurra ai settecento metri di gara le ha permesso di scrollarsi di dosso le avversarie per aver quel minimo di luce necessaria per chiudere la prova davanti alla temibile tedesca Isabel Gose che ha condotto la prima parte di gara(4.00.01), segue per il bronzo l’unghereseAnya Kesely (4.00.04), la nostra portacolori è l’unica a coprire la distanza sotto i 4 minuti (3.59.75). Photo Giorgio Scala / Deepbluemedia / Insidefoto Sono arrivata sul blocchetto con la consapevolezza di volere conquistare l’oro. Sono stati giorni un po’ difficili, anche perché abbiamo preparato le gare pure pensando agli assoluti; poi si è accesa una lampadina. Vedere 3’59 è meraviglioso; ci provavo già dalla scorsa stagione.
    [Show full text]