Scarlet Fever Fact Sheet

Total Page:16

File Type:pdf, Size:1020Kb

Scarlet Fever Fact Sheet Scarlet Fever Fact Sheet Scarlet fever is a rash illness caused by a bacterium called Group A Streptococcus (GAS) The disease most commonly occurs with GAS pharyngitis (“strep throat”) [See also Strep Throat fact sheet]. Scarlet fever can occur at any age, but it is most frequent among school-aged children. Symptoms usually start 1 to 5 days after exposure and include: . Sandpaper-like rash, most often on the neck, chest, elbows, and on inner surfaces of the thighs . High fever . Sore throat . Red tongue . Tender and swollen neck glands . Sometimes nausea and vomiting Scarlet fever is usually spread from person to person by direct contact The strep bacterium is found in the nose and/or throat of persons with strep throat, and can be spread to the next person through the air with sneezing or coughing. People with scarlet fever can spread the disease to others until 24 hours after treatment. Treatment of scarlet fever is important Persons with scarlet fever can be treated with antibiotics. Treatment is important to prevent serious complications such as rheumatic fever and kidney disease. Infected children should be excluded from child care or school until 24 hours after starting treatment. Scarlet fever and strep throat can be prevented . Cover the mouth when coughing or sneezing. Wash hands after wiping or blowing nose, coughing, and sneezing. Wash hands before preparing food. See your doctor if you or your child have symptoms of scarlet fever. Maryland Department of Health Infectious Disease Epidemiology and Outbreak Response Bureau Prevention and Health Promotion Administration Web: http://health.maryland.gov February 2013 .
Recommended publications
  • The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections
    toxins Review The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections Patience Shumba 1, Srikanth Mairpady Shambat 2 and Nikolai Siemens 1,* 1 Center for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, University of Greifswald, D-17489 Greifswald, Germany; [email protected] 2 Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland; [email protected] * Correspondence: [email protected]; Tel.: +49-3834-420-5711 Received: 20 May 2019; Accepted: 10 June 2019; Published: 11 June 2019 Abstract: Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major pathogens associated with monomicrobial NSTIs. In the tissue environment, both Gram-positive bacteria secrete a variety of molecules, including pore-forming exotoxins, superantigens, and proteases with cytolytic and immunomodulatory functions. The present review summarizes the current knowledge about streptococcal and staphylococcal toxins in NSTIs with a special focus on their contribution to disease progression, tissue pathology, and immune evasion strategies. Keywords: Streptococcus pyogenes; group A streptococcus; Staphylococcus aureus; skin infections; necrotizing soft tissue infections; pore-forming toxins; superantigens; immunomodulatory proteases; immune responses Key Contribution: Group A streptococcal and Staphylococcus aureus toxins manipulate host physiological and immunological responses to promote disease severity and progression. 1. Introduction Necrotizing soft tissue infections (NSTIs) are rare and represent a more severe rapidly progressing form of soft tissue infections that account for significant morbidity and mortality [1].
    [Show full text]
  • Invasive Group a Streptococcal Disease Communicable Disease Control Unit
    Public Health and Primary Health Care Communicable Disease Control 4th Floor, 300 Carlton St, Winnipeg, MB R3B 3M9 T 204 788-6737 F 204 948-2040 www.manitoba.ca November, 2015 Re: Streptococcal Invasive Disease (Group A) Reporting and Case Investigation Reporting of Streptococcal invasive disease (Group A) (Streptococcus pyogenes) is as follows: Laboratory: All specimens isolated from sterile sites (refer to list below) that are positive for S. pyogenes are reportable to the Public Health Surveillance Unit by secure fax (204-948-3044). Health Care Professional: Probable (clinical) cases of Streptococcal invasive disease (Group A) are reportable to the Public Health Surveillance Unit using the Clinical Notification of Reportable Diseases and Conditions form (http://www.gov.mb.ca/health/publichealth/cdc/protocol/form13.pdf) ONLY if a positive lab result is not anticipated (e.g., poor or no specimen taken, person has recovered). Cooperation in Public Health investigation (when required) is appreciated. Regional Public Health or First Nations Inuit Health Branch (FNIHB): Cases will be referred to Regional Public Health or FNIHB. Completion and return of the Communicable Disease Control Investigation Form is generally not required, unless otherwise directed by a Medical Officer of Health. Sincerely, “Original Signed By” “Original Signed By” Richard Baydack, PhD Carla Ens, PhD Director, Communicable Disease Control Director, Epidemiology & Surveillance Public Health and Primary Health Care Public Health and Primary Health Care Manitoba Health, Healthy Living and Seniors Manitoba Health, Healthy Living and Seniors The sterile and non-sterile sites listed below represent commonly sampled body sites for the purposes of diagnosis, but the list is not exhaustive.
    [Show full text]
  • Toxic Shock-Like Syndrome Associated with Necrotizing Streptococcus Pyogenes Infection
    Henry Ford Hospital Medical Journal Volume 37 Number 2 Article 5 6-1989 Toxic Shock-like Syndrome Associated with Necrotizing Streptococcus Pyogenes Infection Thomas J. Connolly Donald J. Pavelka Eugene F. Lanspa Thomas L. Connolly Follow this and additional works at: https://scholarlycommons.henryford.com/hfhmedjournal Part of the Life Sciences Commons, Medical Specialties Commons, and the Public Health Commons Recommended Citation Connolly, Thomas J.; Pavelka, Donald J.; Lanspa, Eugene F.; and Connolly, Thomas L. (1989) "Toxic Shock- like Syndrome Associated with Necrotizing Streptococcus Pyogenes Infection," Henry Ford Hospital Medical Journal : Vol. 37 : No. 2 , 69-72. Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol37/iss2/5 This Article is brought to you for free and open access by Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Henry Ford Hospital Medical Journal by an authorized editor of Henry Ford Health System Scholarly Commons. Toxic Shock-like Syndrome Associated with Necrotizing Streptococcus Pyogenes Infection Thomas J. Connolly,* Donald J. Pavelka, MD,^ Eugene F. Lanspa, MD, and Thomas L. Connolly, MD' Two patients with toxic shock-like syndrome are presented. Bolh patients had necrotizing cellulitis due to Streptococcus pyogenes, and both patients required extensive surgical debridement. The association of Streptococcus pyogenes infection and toxic shock-like syndrome is discussed. (Henry Ford Hosp MedJ 1989:37:69-72) ince 1978, toxin-producing strains of Staphylococcus brought to the emergency room where a physical examination revealed S aureus have been implicated as the cause of the toxic shock a temperature of 40.9°C (I05.6°F), blood pressure of 98/72 mm Hg, syndrome (TSS), which is characterized by fever and rash and respiration of 36 breaths/min, and a pulse of 72 beats/min.
    [Show full text]
  • VENEREAL DISEASES in ETHIOPIA Survey and Recommendations THORSTEIN GUTHE, M.D., M.P.H
    Bull. World Hlth Org. 1949, 2, 85-137 10 VENEREAL DISEASES IN ETHIOPIA Survey and Recommendations THORSTEIN GUTHE, M.D., M.P.H. Section on Venereal Diseases World Health Organization Page 1. Prevalent diseases . 87 1.1 Historical .............. 87 1.2 Distribution.............. 88 2. Syphilis and related infections . 89 2.1 Spread factors . 89 2.2 Nature of syphilis . 91 2.3 Extent of syphilis problem . 98 2.4 Other considerations . 110 3. Treatment methods and medicaments . 114 3.1 Ancient methods of treatment . 114 3.2 Therapy and drugs . 115 4. Public-health organization. 116 4.1 Hospital facilities . 117 4.2 Laboratory facilities . 120 4.3 Personnel .............. 121 4.4 Organizational structure . 122 4.5 Legislation.............. 124 5. Recommendations for a venereal-disease programme . 124 5.1 General measures. ........... 125 5.2 Personnel, organization and administration . 126 5.3 Collection of data . 127 5.4 Diagnostic and laboratory facilities . 129 5.5 Treatment facilities . 130 5.6 Case-finding, treatment and follow-up . 131 5.7 Budget. ......... ... 134 6. Summary and conclusions . 134 References . 136 In spite of considerable handicaps, valuable developments in health took place in Ethiopia during the last two decades. This work was abruptly arrested by the war, and the fresh start necessary on the liberation of the country emphasized that much health work still remains to be done. A realistic approach to certain disease-problems and the necessity for compe- tent outside assistance to tackle such problems form the basis for future work. The accomplishments of the Ethiopian Government in the limited time since the war bode well for the future.
    [Show full text]
  • WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA).
    [Show full text]
  • Strep Throat and Scarlet Fever N
    n Strep Throat and Scarlet Fever n After a few days, the rash begins to fade. The skin usually Strep throat is caused by infection with the bac- begins to peel, as it often does after a sunburn. teria Streptococcus. In addition to sore throat, swollen glands, and other symptoms, some chil- What are some possible dren develop a rash. When this rash is present, the infection is called scarlet fever. If your child complications of scarlet fever? has a strep infection, he or she will need antibio- Strep infection has some potentially serious complica- tics to treat it and to prevent rheumatic fever, tions. With proper treatment, most of these can be pre- which can be serious. vented. Complications include: Strep infection may cause an abscess (localized area of pus) in the throat. What are strep throat and scarlet Rheumatic fever. This disease develops a few weeks after fever? the original strep infection. It is felt to be caused by our immune system. It can be serious and can cause fever, heart Most sore throats are caused by virus, but strep throat is inflammation, arthritis, and other symptoms. Your child caused by the bacteria Group A Strepococcus. Treatment can be left with heart problems called rheumatic disease. of this infection with antibiotics may help your child feel Rheumatic fever is uncommon now and can be prevented better and prevent rheumatic fever. by treating the strep infection properly with antibiotics. Some children with strep throat or strep infections else- where may develop a rash. When that occurs, the infection Acute glomerulonephritis.
    [Show full text]
  • Chapter 11 – PROKARYOTES: Survey of the Bacteria & Archaea
    Chapter 11 – PROKARYOTES: Survey of the Bacteria & Archaea 1. The Bacteria 2. The Archaea Important Metabolic Terms Oxygen tolerance/usage: aerobic – requires or can use oxygen (O2) anaerobic – does not require or cannot tolerate O2 Energy usage: autotroph – uses CO2 as a carbon source • photoautotroph – uses light as an energy source • chemoautotroph – gets energy from inorganic mol. heterotroph – requires an organic carbon source • chemoheterotroph – gets energy & carbon from organic molecules …more Important Terms Facultative vs Obligate: facultative – “able to, but not requiring” e.g. • facultative anaerobes – can survive w/ or w/o O2 obligate – “absolutely requires” e.g. • obligate anaerobes – cannot tolerate O2 • obligate intracellular parasite – can only survive within a host cell The 2 Prokaryotic Domains Overview of the Bacterial Domain We will look at examples from several bacterial phyla grouped largely based on rRNA (ribotyping): Gram+ bacteria • Firmicutes (low G+C), Actinobacteria (high G+C) Proteobacteria (Gram- heterotrophs mainly) Gram- nonproteobacteria (photoautotrophs) Chlamydiae (no peptidoglycan in cell walls) Spirochaetes (coiled due to axial filaments) Bacteroides (mostly anaerobic) 1. The Gram+ Bacteria Gram+ Bacteria The Gram+ bacteria are found in 2 different phyla: Firmicutes • low G+C content (usually less than 50%) • many common pathogens Actinobacteria • high G+C content (greater than 50%) • characterized by branching filaments Firmicutes Characteristics associated with this phylum: • low G+C Gram+ bacteria
    [Show full text]
  • WO 2013/042140 A4 28 March 2013 (28.03.2013) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2013/042140 A4 28 March 2013 (28.03.2013) P O P C T (51) International Patent Classification: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, A61K 31/197 (2006.01) A61K 45/06 (2006.01) RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, A61K 31/60 (2006.01) A61P 31/00 (2006.01) TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, A61K 33/22 (2006.01) ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/IN20 12/000634 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (22) International Filing Date UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 24 September 2012 (24.09.2012) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: ML, MR, NE, SN, TD, TG). 2792/DEL/201 1 23 September 201 1 (23.09.201 1) IN Declarations under Rule 4.17 : (72) Inventor; and — of inventorship (Rule 4.17(iv)) (71) Applicant : CHAUDHARY, Manu [IN/IN]; 51-52, In dustrial Area Phase- 1, Panchkula 1341 13 (IN).
    [Show full text]
  • Streptococcus Pneumoniae Technical Sheet
    technical sheet Streptococcus pneumoniae Classification On necropsy, a serosanguineous to purulent exudate Alpha-hemolytic, Gram-positive, encapsulated, aerobic is often found in the nasal cavities and the tympanic diplococcus bullae. The lungs can have areas of firm, dark red consolidation. Fibrinopurulent pleuritis, pericarditis, Family and peritonitis are other changes seen on necropsy of animals affected by S. pneumoniae. Histologic Streptococcaceae lesions are consistent with necropsy findings, Affected species and bronchopneumonia of varying severity and fibrinopurulent serositis are often seen. Primarily described as a pathogen of rats and guinea pigs. Mice are susceptible to infection. Agent of human Diagnosis disease and human carriers are a likely source of An S. pneumoniae infection should be suspected if animal infections. Zoonotic infection is possible. encapsulated Gram-positive diplococci are seen on a smear from a lesion. Confirmation of the diagnosis is Frequency via culture of lesions or affected tissues. S. pneumoniae Rare in modern laboratory animal colonies. Prevalence grows best on 5% blood agar and is alpha-hemolytic. in pet and wild populations unknown. The organism is then presumptively identified with an optochin test. PCR assays are also available for Transmission diagnosis. PCR-based screening for S. pneumoniae Transmission is primarily via aerosol or contact with may be conducted on respiratory samples or feces. nasal or lacrimal secretions of an infected animal. S. PCR may also be useful for confirmation of presumptive pneumoniae may be cultured from the nasopharynx and microbiologic identification or confirming the identity of tympanic bullae. bacteria observed in histologic lesions. Clinical Signs and Lesions Interference with Research Inapparent infections and carrier states are common, Animals carrying S.
    [Show full text]
  • A Case of Severe Human Granulocytic Anaplasmosis in an Immunocompromised Pregnant Patient
    Elmer ress Case Report J Med Cases. 2015;6(6):282-284 A Case of Severe Human Granulocytic Anaplasmosis in an Immunocompromised Pregnant Patient Marijo Aguileraa, c, Anne Marie Furusethb, Lauren Giacobbea, Katherine Jacobsa, Kirk Ramina Abstract festations include respiratory or neurologic involvement, acute renal failure, invasive opportunistic infections and a shock- Human granulocytic anaplasmosis (HGA) is a tick-borne disease that like illness [2-4]. Recent delineation of the various species can often result in persistent fevers and other non-specific symptoms associated with ehrlichia infections and an increased under- including myalgias, headache, and malaise. The incidence among en- standing of the epidemiology has augmented our knowledge of demic areas has been increasing, and clinician recognition of disease these tick-borne diseases. However, a detailed understanding symptoms has aided in the correct diagnosis and treatment of patients of HGA infections in both immunocompromised and pregnant who have been exposed. While there have been few cases reported of patients is limited. We report a case of a severe HGA infection HGA disease during pregnancy, all patients have undergone a rela- presenting as an acute exacerbation of Crohn’s disease in a tively mild disease course without complications. HGA may cause pregnant immunocompromised patient. more severe disease in the elderly and immunocompromised. Herein, we report an unusual presentation and severe disease complications of HGA in a pregnant female who was concomitantly immunocompro- Case Report mised due to azathioprine treatment of her Crohn’s disease. Follow- ing successful treatment with rifampin, she subsequently delivered a A 34-year-old primigravida at 17+2 weeks’ gestation presented healthy female infant without any disease sequelae.
    [Show full text]
  • Severe Streptococcal Infection
    SEVERE STREPTOCOCCAL INFECTION „AN OLD BUT ACTIVE ENEMY‟ Dr Graham Douglas Aberdeen Royal Infirmary TOP 3 CAUSES OF DEATH IN THE UK 1 Ischaemic Heart Disease (101,000 deaths & falling) 2 Sepsis/Pneumonia (33,000 deaths & rising) 3 Lung Cancer (29,000 deaths & rising in women) STREPTOCOCCI • Spherical Gram – positive bacteria • Cellular division occurs along a single axis – so grow in chains or pairs. (Streptos – Greek meaning „twisted chain‟) • In contrast Staphylococci divide along multiple axes so appear in „grape-like‟ clusters. PATHOGENIC SPECIES • S. agalactiae • S. pneumoniae • S. anginosus • S. pyogenes • S. bovis • S. ratti • S. canis • S. salivarius • S. equi • S. salivarius ssp. • S. iniae thermophilus • S. mitis • S. sanguinis • S. mutans • S. sobrinus • S. oralis • S. suis • S. parasanguinis • S. uberis • S. perosis • S. vestibularis • S. viridans 22 species described STREPTOCOCCUS β –haemolytic α – haemolytic γ – clear, green, haemolytic complete haemolysis partial haemolysis no haemolysis pyogenes agalactiae pneumoniae viridans enterococcus Group A Group B mutans, sanguis E. faecalis Bacitracin sensitive Bacitracin resistant E. faecium Classification of streptococcus Streptococcus pyogenes is Group A beta-haemolytic STREPTOCOCCUS PYOGENES • Nowadays known as GROUP A STREPTOCOCCUS (GAS) • Associated exclusively with human infection • Only human reservoir is skin or mucous membranes • Classified by Rebecca Lancefield, US Microbiologist in 1928 – based on its M. protein, surface virulence factor Facilitates adhesion Responsible for ß-haemolysis on blood agar release of lysosomal contents with subsequent cell death. Cleaves and inactivates human C5a Antiphagocytic activity Induce fever Lyse RBSc, PMNLs and platelets Degrade hyaluronic acid, spread of infection along fascial planes Schematic diagram showing the location of virulence-associated products of Str.
    [Show full text]
  • Scarlet Fever
    BOSTON PUBLIC HEALTH COMMISSION | FACT SHEET Scarlet Fever What is scarlet fever? Scarlet fever is a bacterial infection caused by group A strep, the same type of bacteria that causes strep throat. What are the symptoms? Common symptoms include: • A red rash with a sandpaper feel that covers most of the body • A very red, sore throat • A fever of 101˚F or above • Bright red skin in the crease of the underarm, elbow, and groin areas • A red and bumpy tongue • A whitish coating on the tongue • Swollen glands in the neck Other general symptoms include: • Headache and body aches • Nausea, vomiting, or abdominal pain How is it spread? Scarlet fever is spread through contact with droplets from and infected person’s cough or sneeze. If you touch your mouth, nose, or eyes after coming into contact with these droplets, you may become infected. You can also get sick after sharing the same drinking glass or utensils with a sick person. It is possible to get scarlet fever from contact with sores from group A strep skin infections. For people diagnosed with scarlet fever, it is important for them to change their toothbrush after 1-2 days on antibiotics to avoid re-infecting themselves. Who gets scarlet fever? Although anyone can get scarlet fever, children and some adults are more likely to get infected than others. It is most common in children between the ages of 5 and 15. Adults who are in contact with children are at higher risk for scarlet fever than other adults. Crowded conditions, such as schools and daycare centers, can increase the risk of spreading the infection.
    [Show full text]