Chemical Weapon Threats—Are You Prepared
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The Detection and Determination of Esters
Louisiana State University LSU Digital Commons LSU Historical Dissertations and Theses Graduate School 1958 The etD ection and Determination of Esters. Mohd. Mohsin Qureshi Louisiana State University and Agricultural & Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_disstheses Recommended Citation Qureshi, Mohd. Mohsin, "The eD tection and Determination of Esters." (1958). LSU Historical Dissertations and Theses. 501. https://digitalcommons.lsu.edu/gradschool_disstheses/501 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Historical Dissertations and Theses by an authorized administrator of LSU Digital Commons. For more information, please contact [email protected]. Copright by Mohcl Mohsin Qureshi 1959 THE DETECTION AND DETERMINATION OF ESTERS A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Department of Chemistry by Mohd. Mohsin Qureshi M.Sc., Aligarh University, 1944 August, 1958 ACKNOWLEDGMENT The author wishes to express his sincere apprecia tion and gratitude to Dr. Philip W. West under whose guidance this research was carried out. He is grateful to Dr. James G. Traynham for sup plying him with a number of esters and for his many helpful suggestions. The financial support given to him by the Continental Oil Company is gratefully acknowledged. He offers his sincere thanks to Miss Magdalena Usategul for her valuable suggestions and her ungrudging help during the course of this investigation. Dr. Anil K. -
Critical Care Management of Chemical Exposures 4 the Patients Were Decontaminated Prior to Arriving at the Hospital
Chapter 4: CRITI C AL CARE MANAGE M ENT OF CHE M I C AL EXPOSURES James Geiling, MD, FCCM Vincent M. Nicolais, MD, FCCM Gregory M. Susla, PharmD, FCCM The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs. Objectives ■ Review measures of preparedness and planning. ■ Describe the purpose of decontamination. ■ Discuss how to evaluate whether a patient has been adequately decontaminated to enter the emergency department (ED), hospital, or intensive care unit (ICU). ■ Summarize the steps necessary to protect hospital staff: decontamination, personal protective equipment (PPE). ■ Review specific agents: diagnosis, identification, and management. If supposedly civilized nations confined their warfare to attacks on the enemy’s troops, the matter of defense against warfare chemicals would be purely a military problem, and therefore beyond the scope of this study. But such is far from the case. In these days of total warfare, the civilians, including women and children, are subject to attack at all times. Colonel Edgar Erskine Hume, Victories of Army Medicine, 1943 Fundamental Disaster Management Case Study A young couple was transported to your hospital’s ED from a local cinema. You have been told there are many others who are being cared for by the emergency medical services and are en route. The 18-year-old male and 17-year-old female were admitted to your ICU after intubation and placement on mechanical ventilation. They are unresponsive and diaphoretic, and they have constricted pupils with excessive lacrimation, vomiting, diarrhea, and restlessness. -
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Terrorism WHAT CLINICIANS and NEED TO Disaster KNOW Sarin Sponsored for CME Credit by Rush University Medical Center Release Date: April 1, 2005 Expiration Date: March 31, 2007 errorism WHAT T CLINICIANS and NEED TO Disaster KNOW SERIES Uniformed Services University Guest Faculty EDITORS Health Sciences Ronald E. Goans, PhD, MD, MPH* Bethesda, Maryland Clinical Associate Professor Rush University Tulane University School of Public Health & David M. Benedek, MD, LTC, MC, USA Medical Center Tropical Medicine Associate Professor of Psychiatry Chicago, Illinois New Orleans, LA Stephanie R. Black, MD* Steven J. Durning, MD, Maj, USAF, MC* Sunita Hanjura, MD* Assistant Professor of Medicine Associate Professor of Medicine Rockville Internal Medicine Group Section of Infectious Diseases Rockville, MD Department of Internal Medicine Thomas A. Grieger, MD, CAPT, MC, USN* Associate Professor of Psychiatry Niranjan Kanesa-Thasan, MD, MTMH* Daniel Levin, MD* Associate Professor of Military & Director, Medical Affairs & Pharmacovigilance Assistant Professor Emergency Medicine Acambis General Psychiatry Residency Director Assistant Chair of Psychiatry for Graduate Cambridge, MA Department of Psychiatry & Continuing Education Jennifer C. Thompson, MD, MPH, FACP* Gillian S. Gibbs, MPH* Molly J. Hall, MD, Col, USAF, MC, FS* Chief, Department of Clinical Investigation Project Coordinator Assistant Chair & Associate Professor William Beaumont Army Medical Center Center of Excellence for Bioterrorism Department of Psychiatry El Paso, TX Preparedness Derrick Hamaoka, MD, Capt, USAF, MC, FS* Faculty Disclosure Policy Linnea S. Hauge, PhD* Director, Third Year Clerkship It is the policy of the Rush University Medical Educational Specialist Instructor of Psychiatry Department of General Surgery Center Office of Continuing Medical Paul A. Hemmer, MD, MPH, Lt Col, USAF, MC* Education to ensure that its CME activities Associate Professor of Medicine are independent, free of commercial bias AUTHORS and beyond the control of persons or organi- Rush University Benjamin W. -
Pacs by Chemical Name (Mg/M3) (Pdf)
Table 4: Protective Action Criteria (PAC) Rev 25 based on applicable 60-minute AEGLs, ERPGs, or TEELs. Values are presented in mg/m3. August 2009 Table 4 is an alphabetical listing of the chemicals in the PAC data set. It provides Chemical Abstract Service Registry Numbers (CASRNs)1, PAC values, and technical information on the source of the PAC values. Table 4 presents all values for TEEL-0, PAC-1, PAC-2, and PAC-3 in mg/m3. The conversion of ppm to mg/m3 is calculated assuming 25 ºC and 760 mm Hg. The columns presented in Table 4 provide the following information: Heading Definition No. The ordered numbering of the chemicals as they appear in this alphabetical listing. Chemical Name The chemical name given to the PAC Development Team. CASRN The Chemical Abstract Service Registry Number for this chemical. TEEL-0 This is the threshold concentration below which most people will experience no adverse health effects. This PAC is always based on TEEL-0 because AEGL-0 or ERPG-0 values do not exist. PAC-1 Based on the applicable AEGL-1, ERPG-1, or TEEL-1 value. PAC-2 Based on the applicable AEGL-2, ERPG-2, or TEEL-2 value. PAC-3 Based on the applicable AEGL-3, ERPG-3, or TEEL-3 value. Source of PACs: Technical comments provided by the PAC development team that TEEL-0, PAC-1, indicate the source of the data used to derive PAC values. Future efforts PAC-2, PAC-3 are directed at reviewing, revising, and enhancing this information. -
High-Threat Chemical Agents: Characteristics, Effects, and Policy Implications
Order Code RL31861 CRS Report for Congress Received through the CRS Web High-Threat Chemical Agents: Characteristics, Effects, and Policy Implications Updated September 9, 2003 Dana A. Shea Analyst in Science and Technology Policy Resources, Science, and Industry Division Congressional Research Service ˜ The Library of Congress High-Threat Chemical Agents: Characteristics, Effects, and Policy Implications Summary Terrorist use of chemical agents has been a noted concern, highlighted after the Tokyo Sarin gas attacks of 1995. The events of September 11, 2001, increased Congressional attention towards reducing the vulnerability of the United States to such attacks. High-threat chemical agents, which include chemical weapons and some toxic industrial chemicals, are normally organized by military planners into four groups: nerve agents, blister agents, choking agents, and blood agents. While the relative military threat posed by the various chemical types has varied over time, use of these chemicals against civilian targets is viewed as a low probability, high consequence event. High-threat chemical agents, depending on the type of agent used, cause a variety of symptoms in their victims. Some cause death by interfering with the nervous system. Some inhibit breathing and lead to asphyxiation. Others have caustic effects on contact. As a result, chemical attack treatment may be complicated by the need to identify at least the type of chemical used. Differences in treatment protocols for the various high-threat agents may also strain the resources of the public health system, especially in the case of mass casualties. Additionally, chemical agents trapped on the body or clothes of victims may place first responders and medical professionals at risk. -
Toxicological Profile for Acetone Draft for Public Comment
ACETONE 1 Toxicological Profile for Acetone Draft for Public Comment July 2021 ***DRAFT FOR PUBLIC COMMENT*** ACETONE ii DISCLAIMER Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services. This information is distributed solely for the purpose of pre dissemination public comment under applicable information quality guidelines. It has not been formally disseminated by the Agency for Toxic Substances and Disease Registry. It does not represent and should not be construed to represent any agency determination or policy. ***DRAFT FOR PUBLIC COMMENT*** ACETONE iii FOREWORD This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a relevance to public health discussion which would allow a public health professional to make a real-time determination of whether the presence of a particular substance in the environment poses a potential threat to human health. -
Chemical Warfare Agents
Manuscript for Kirk-Othmer Encyclopedia of Chemical Technology August 2019 CHEMICAL WARFARE AGENTS This is the pre-print manuscript of an article published in the Kirk-Othmer Encyclopedia of Chemical Technology: https://onlinelibrary.wiley.com/doi/book/10.1002/0471238961 The published version of the article is available at the Wiley website: https://onlinelibrary.wiley.com/doi/10.1002/0471238961.0308051308011818.a01.pub3 How to cite: Costanzi, S. (2020). Chemical Warfare Agents. In Kirk‐Othmer Encyclopedia of Chemical Technology, (Ed.). doi:10.1002/0471238961.0308051308011818.a01.pub3 Stefano Costanzi Department of Chemistry and Center for Behavioral Neuroscience American University, Washington, D.C. [email protected] Chemical weapons are weapons that exploit the toxicity of chemicals to bring about death or harm. The toxic chemicals on which chemical weapons are based are known as chemical warfare agents. The elimination of this entire category of weapons is the aim of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction, also known as Chemical Weapons Convention or CWC, which was opened for signature in 1993 and entered into force in 1997. Administered and implemented by the Hague- based Organisation for the Prohibition of Chemical Weapons (OPCW), the CWC is an international treaty that enjoys almost universal embracement, having been ratified or acceded by 193 States Parties. Importantly, the CWC poses a complete and absolute ban on chemical weapons, mandating State Parties to renounce “(a) to develop, produce, otherwise acquire, stockpile or retain chemical weapons, or transfer, directly or indirectly, chemical weapons to anyone; (b) to use chemical weapons; (c) to engage in any military preparations to use chemical weapons; (d) to assist, encourage or induce, in any way, anyone to engage in any activity prohibited to a State Party” under the Convention (CWC Article II, Paragraph 1) (1-3). -
Introduction to Emergency Management Second Edition
Introduction to Emergency Management Second Edition Introduction to Emergency Management Second Edition George D. Haddow Jane A. Bullock With Contributions by Damon P. Coppola Amsterdam • Boston • Heidelberg • London • New York • Oxford • Paris San Diego • San Francisco • Singapore • Sydney • Tokyo Elsevier Butterworth–Heinemann 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA Linacre House, Jordan Hill, Oxford OX2 8DP, UK Copyright © 2006, Elsevier Inc. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: permissions@elsevier. co.uk. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting “Customer Support” and then “Obtaining Permissions.” Recognizing the importance of preserving what has been written, Elsevier prints its books on acid-free paper whenever possible. Library of Congress Cataloging-in-Publication Data Haddow, George D. Introduction to emergency management / George D. Haddow, Jane A. Bullock. — 2nd ed. p. cm. Includes bibliographical references and index. ISBN 0-7506-7961-1 (hardcover : alk. paper) 1. Emergency management. 2. Emergency management—United States. I. Bullock, Jane A. II. Title. HV551.2.H3 -
4Cyanide and Fumigants February 2014 Hoffman
Module Four: Cyanide & Fumigants Robert Hoffman MD, FACMT American College of Medical Toxicology Ottawa, Ontario February 5, 2014 Chemical Agents of Opportunity 1 Faculty Disclosure • Faculty: Robert Hoffman MD – Relationships with commercial interests: none – Speakers Bureau/Honoraria: none – Consulting Fees: none – Other: none 2 Learning Objectives • Indicate the sources and uses of cyanide and fumigants • Describe therapies used to treat cyanide poisoning • List the four most common fumigant gases • Describe the clinical effects of exposure to these gases • Explain how to treat victims exposed to these gases 3 1 Cyanide & Fumigants • Cyanide – Salts (solids) – Gas • Fumigant gases – Vikane (sulfuryl fluoride) – Methyl bromide – Phosphine 4 Cyanide • Notoriety well deserved • Historical relevance – Mass poisoning • Pharmaceutical terrorism • Weapon of Mass Destruction 5 Cyanide (CN): Properties • Small molecule (26 Dalton) • Boiling Point 27.7°C • Colorless • Bitter Almonds? Myth • Water soluble 6 2 Cyanide: Two Common Forms Hydrogen Cyanide Solid Cyanide Salts Gas (sodium cyanide, potassium cyanide, calcium cyanide) Toxic when Inhaled Toxic when Ingested 7 Generating HCN Gas from Salts 8 Cyanide • Sources of cyanide (solid) – Industrial applications (electroplating, hardening steel, mining, fumigation,…) – Sodium, potassium and calcium cyanide are all readily purchased on the internet • Other sources – Cyanogen chloride – Acetonitrile, acrylonitrile – Natural occurring cyanogens (laetrile) 9 3 Cyanide: Mechanism of Action • Readily -
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A Thesis Submitted for the Degree of PhD at the University of Warwick Permanent WRAP URL: http://wrap.warwick.ac.uk/139966 Copyright and reuse: This thesis is made available online and is protected by original copyright. Please scroll down to view the document itself. Please refer to the repository record for this item for information to help you to cite it. Our policy information is available from the repository home page. For more information, please contact the WRAP Team at: [email protected] warwick.ac.uk/lib-publications I A STUDY OF OLFACTORY MECHANISMS by DAVID JAMES SQUIRRELL, BSc. A thesis submitted for the degree of Doctor of Philosophy in the Department of Chemistry and Molecular Science at the University of Warwick December. 1978 I i CONTE NTS PAGE CHAPTER 1 INTRODUCTION: THE VERTEBRATE OLFACTORY SYSTEM 1 1.1 Morphology 1 i ) Macroscopic 1 11 ) Microscopic 5 a) Olfactory neurons 7 b) Cilia 9 c) Mucus 10 d) Supporting cells 11 e) Basal cells 11 f) Axons 12 g) Contacts between cells 12 h) The lamina propria 13 ili) Cell dynamics in the olfactory epi thelium 14 Î V ) Experimentally induced degeneration and subsequent regeneration of the olfactory epithelium 15 1.2 Epi thelium 17 i ) The electro-olfactogram or EOG 19 i i ) Pos i t i ve EOG's 31 ili) Frequency of occurence of the various types of EOG 33 iv) Cellular origins of slow potentials in the olfactory epithelium 34 V) Ionic mechanisms 36 vi ) Generator currents in the olfactory epithelium 37 Vi i ) The site of transduction 41 1.3 Pp-~essing of Olfactory Information 43 -
2020 Emergency Response Guidebook
2020 A guidebook intended for use by first responders A guidebook intended for use by first responders during the initial phase of a transportation incident during the initial phase of a transportation incident involving hazardous materials/dangerous goods involving hazardous materials/dangerous goods EMERGENCY RESPONSE GUIDEBOOK THIS DOCUMENT SHOULD NOT BE USED TO DETERMINE COMPLIANCE WITH THE HAZARDOUS MATERIALS/ DANGEROUS GOODS REGULATIONS OR 2020 TO CREATE WORKER SAFETY DOCUMENTS EMERGENCY RESPONSE FOR SPECIFIC CHEMICALS GUIDEBOOK NOT FOR SALE This document is intended for distribution free of charge to Public Safety Organizations by the US Department of Transportation and Transport Canada. This copy may not be resold by commercial distributors. https://www.phmsa.dot.gov/hazmat https://www.tc.gc.ca/TDG http://www.sct.gob.mx SHIPPING PAPERS (DOCUMENTS) 24-HOUR EMERGENCY RESPONSE TELEPHONE NUMBERS For the purpose of this guidebook, shipping documents and shipping papers are synonymous. CANADA Shipping papers provide vital information regarding the hazardous materials/dangerous goods to 1. CANUTEC initiate protective actions. A consolidated version of the information found on shipping papers may 1-888-CANUTEC (226-8832) or 613-996-6666 * be found as follows: *666 (STAR 666) cellular (in Canada only) • Road – kept in the cab of a motor vehicle • Rail – kept in possession of a crew member UNITED STATES • Aviation – kept in possession of the pilot or aircraft employees • Marine – kept in a holder on the bridge of a vessel 1. CHEMTREC 1-800-424-9300 Information provided: (in the U.S., Canada and the U.S. Virgin Islands) • 4-digit identification number, UN or NA (go to yellow pages) For calls originating elsewhere: 703-527-3887 * • Proper shipping name (go to blue pages) • Hazard class or division number of material 2. -
Toxidrome Recognition in Chemical- Weapons Attacks
The new england journal of medicine Review Article Dan L. Longo, M.D., Editor Toxidrome Recognition in Chemical- Weapons Attacks Gregory R. Ciottone, M.D. errorist attacks are increasing in both frequency and com- From Beth Israel Deaconess Medical plexity around the world. In 2016 alone, there were more than 13,400 ter- Center, Harvard Medical School, Boston. 1 Address reprint requests to Dr. Ciottone rorist attacks globally, killing more than 34,000 people. Of equal concern, at Beth Israel Deaconess Medical Center, T Dept. of Emergency Medicine, Rosenberg chemical-warfare agents that were developed for the battlefield are being used on civilians in major cities and conflict zones. The recent sarin attacks in Syria,2,3 the Building, 1 Deaconess Rd., Boston, MA 02215, or at gciotton@ bidmc . harvard . edu. latest in a series of chemical attacks in that region,3,4 along with the use of the nerve agent VX in the assassination of Kim Jong-nam in Malaysia and the Soviet- N Engl J Med 2018;378:1611-20. 5 DOI: 10.1056/NEJMra1705224 era agent Novichok in the poisoning of Sergei Skripal in the United Kingdom, all Copyright © 2018 Massachusetts Medical Society. represent a worrisome trend in the use of deadly chemical agents by various rogue groups in civilian settings. In light of the rise in coordinated, multimodal terrorist attacks in Western urban centers,6,7 concern has been expressed about an increase in the use of chemical agents by terrorists on civilian targets around the world. Such attacks entail unique issues in on-the-scene safety8,9 and also require a rapid medical response.10 As health care providers, we must be proactive in how we prepare for and respond to this new threat.