The Detection and Determination of Esters
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development
processes Review Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development Outi M. H. Salo-Ahen 1,2,* , Ida Alanko 1,2, Rajendra Bhadane 1,2 , Alexandre M. J. J. Bonvin 3,* , Rodrigo Vargas Honorato 3, Shakhawath Hossain 4 , André H. Juffer 5 , Aleksei Kabedev 4, Maija Lahtela-Kakkonen 6, Anders Støttrup Larsen 7, Eveline Lescrinier 8 , Parthiban Marimuthu 1,2 , Muhammad Usman Mirza 8 , Ghulam Mustafa 9, Ariane Nunes-Alves 10,11,* , Tatu Pantsar 6,12, Atefeh Saadabadi 1,2 , Kalaimathy Singaravelu 13 and Michiel Vanmeert 8 1 Pharmaceutical Sciences Laboratory (Pharmacy), Åbo Akademi University, Tykistökatu 6 A, Biocity, FI-20520 Turku, Finland; ida.alanko@abo.fi (I.A.); rajendra.bhadane@abo.fi (R.B.); parthiban.marimuthu@abo.fi (P.M.); atefeh.saadabadi@abo.fi (A.S.) 2 Structural Bioinformatics Laboratory (Biochemistry), Åbo Akademi University, Tykistökatu 6 A, Biocity, FI-20520 Turku, Finland 3 Faculty of Science-Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands; [email protected] 4 Swedish Drug Delivery Forum (SDDF), Department of Pharmacy, Uppsala Biomedical Center, Uppsala University, 751 23 Uppsala, Sweden; [email protected] (S.H.); [email protected] (A.K.) 5 Biocenter Oulu & Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7 A, FI-90014 Oulu, Finland; andre.juffer@oulu.fi 6 School of Pharmacy, University of Eastern Finland, FI-70210 Kuopio, Finland; maija.lahtela-kakkonen@uef.fi (M.L.-K.); tatu.pantsar@uef.fi -
NINDS Custom Collection II
ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC -
Extraction and Evaporation: Experiment 1 Separating the Components of a Mixture1 Week 1
Organic Chemistry I Laboratory Extraction and Evaporation: Experiment 1 Separating the Components of a Mixture1 Week 1 Background Reading Zubrick, J. W. The Organic Chem Lab Survival Manual, 4th edition, Wiley & Sons, Inc., New York, 1997. Keeping a Notebook: Pg 12-24. Interpreting Handbooks: Pg 26-31, 34-44. Extraction and Washing: Pg 148-168. Background Senario One of the many places organic chemists are employed is in private laboratories associated with consulting firms. The purpose of these labs is generally to provide chemical analysis or synthesis of material for customers. The first few labs in CHM 220 will teach you the basic techniques needed to analyze and purify mixtures to determine the individual components. This first lab will involve determining the composition of a possible pharmaceutical preparation. Watchdog agencies exist which monitor the pharmaceuticals sold over the counter in the United States. These agencies will use private laboratory firms to analyze products suspected of violating enforced standards. For example, a new brand of analgesic may appear on drugstore shelves at a low price. The label indicates that the tablets were manufactured in the United States by a legitimate pharmaceutical company. However, the labels may reveal discrepancies and the appearance/quality of the tablets could lead an investigator to suspect that they might be counterfeit. Such knockoffs of a domestic product can be manufactured cheaply elsewhere and smuggled into the US, where they are sold for high profits. This laboratory exercise places you in the position of analyzing a suspected counterfeit analgesic preparation. The label on the suspected bottle lists the ingredients per tablet as aspirin (200 mg), acetaminophen (250 mg), and sucrose (50 mg). -
Actarit (Rinn) Severe, Active Rheumatoid Arthritis and Active and Ацеметацин Actaritum; MS-932
Abatacept/Adalimumab 15 Preparations Acetanilide concentrations are reached in about 3 to 8 days and bio- Proprietary Preparations (details are given in Part 3) Acetanilida; Antifebrin. N-Phenylacetamide. availability is estimated to be 64%. The mean terminal Arg.: Berlofen; Bristaflam†; Austria: Beofenac†; Belg.: Air-Tal; Biofenac; Антифебрин; Ацетанилид half-life is about 2 weeks. Braz.: Aceflan†; Cecoflan†; Proflam; Chile: Airtal†; Bristaflam†; Denm.: C8H9NO = 135.2. ◊ References. Barcan; Fin.: Barcan; Fr.: Cartrex; Ger.: Beofenac; Gr.: Aceclonac; Arlina; CAS — 103-84-4. Biofenac; Sovipan; Hung.: Aflamin; India: Aceclo; Arrestin; Movon; Zero- 1. Nestorov I. Clinical pharmacokinetics of tumor necrosis factor dol; Ital.: Airtal; Gladio; Kafenac; Mex.: Bristaflam; Neth.: Biofenac; Norw.: antagonists. J Rheumatol 2005; 74 (suppl): 13–18. Barcan; Philipp.: Clanza; Port.: Airtal; Biofenac; Rus.: Airtal (Аэртал); Spain: Airtal; Airtal Difucrem; Falcol; Gerbin; Sanein; Swed.: Barcan; Switz.: Locomin†; UAE: Aceclofar; UK: Preservex; Venez.: Airtal†; Brista- O Uses and Administration flam. Adalimumab is a recombinant human monoclonal tumour necrosis factor (TNF) antibody that binds Multi-ingredient: India: Kinectine; Kinectine P; Kinectine-MR; Movon- N CH3 MR; Movon-P†; Zerodol-MR; Zerodol-P. H specifically to TNF-α and blocks its interaction with endogenous cell-surface TNF receptors. It also modu- Pharmacopoeias. In Fr. lates biological responses that are induced or regulated Profile by TNF. Elevated levels of TNF have been found in the Acemetacin (BAN, rINN) Acetanilide, a para-aminophenol derivative related to paraceta- affected tissues and fluids of patients with rheumatoid Acemetacina; Acémétacine; Acemetacinum; Asemetasin; Bay-f- mol (p.108), has analgesic and antipyretic properties. It was re- placed by safer analgesics. -
Thermodynamics of Mixing of Sodium Naproxen and Procaine Hydrochloride in Ethanol + Water Cosolvent Mixtures
Rev. Colomb. Cienc. Quím. Farm., Vol. 39 (2), 132-148, 2010 www.farmacia.unal.edu.co Artículo de investigación científica Thermodynamics of mixing of sodium naproxen and procaine hydrochloride in ethanol + water cosolvent mixtures Daniel R. Delgado1, Reinaldo G. Sotomayor2, Diego R. Monterroza2, Carolina P. Mora3, Edgar F. Vargas4, Fleming Martínez5* 1 Centro de Investigaciones, Corporación Universitaria Iberoamericana, Bogotá, D. C., Colombia. 2 Laboratorios Procaps, Barranquilla, Colombia. 3 Grupo de Investigaciones Natura, Departamento de Química Farmacéutica, Facultad de Ciencias Naturales, Universidad Icesi, Santiago de Cali, Colombia. 4 Grupo de Termodinámica de Soluciones, Departamento de Química, Facultad de Ciencias, Universidad de los Andes, Bogotá, D. C., Colombia. 5 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, A. A. 14490, Bogotá, D. C., Colombia. * Corresponding Author: E-mail: [email protected]. Recibido para evaluación: 25 de septiembre de 2010 Aceptado para publicación: 15 de octubre de 2010 Summary Thermodynamic functions Gibbs energy, enthalpy, and entropy of mixing of sodium naproxen and procaine hydrochloride were evaluated. Mixing quantities were calculated based on fusion calorimetric values obtained from differential scan- ning calorimetry measurements and equilibrium solubility values reported in the literature for both drugs in ethanol + water mixtures. By means of enthalpy-entropy 0 0 compensation analysis, non-linear ∆H mix vs. Gmix plots were obtained which indi- cates different mechanisms involved in the dissolution of these drugs according to mixtures composition. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear. Keywords: sodium naproxen, procaine hydrochloride, mixing process, cosolvency, ethanol, solution thermodynamics. -
SIGMA-ALDRICH Sigma-Aldrich.Com SAFETY DATA SHEET Version 5.2 Revision Date 03/20/2015 Print Date 05/12/2015
SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET Version 5.2 Revision Date 03/20/2015 Print Date 05/12/2015 1. PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers Product name : Acetanilide Product Number : 112933 Brand : Aldrich CAS-No. : 103-84-4 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +1 800-325-5832 Fax : +1 800-325-5052 1.4 Emergency telephone number Emergency Phone # : (314) 776-6555 2. HAZARDS IDENTIFICATION 2.1 Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 3), H402 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 GHS Label elements, including precautionary statements Pictogram Signal word Warning Hazard statement(s) H302 Harmful if swallowed. H402 Harmful to aquatic life. Precautionary statement(s) P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. Rinse mouth. P501 Dispose of contents/ container to an approved waste disposal plant. 2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none Aldrich - 112933 Page 1 of 7 3. COMPOSITION/INFORMATION ON INGREDIENTS 3.1 Substances Synonyms : N-Phenylacetamide Formula : C8H9NO Molecular weight : 135.16 g/mol CAS-No. -
Laboratory Manual
International Program UAM-Boston University Laboratory Manual Organic Chemistry I 2013-2014 Departamento de Química Orgánica Ernesto Brunet Romero Ana María Martín Castro Ramón Gómez Arrayás Laboratory Manual Table of Contents ............................................................................... 1 Introduction ............................................................................... 2 Prelab preparation ............................................................................... 2 Notebook ............................................................................. 3 Safety .............................................................................. 3 Laboratory Practices and Safety Rules ............................................................. 4 Accidents and injuries ........................................................................... 5 Fires ............................................................................. 5 Chemical Wastes ............................................................................. 6 Cleaning Responsibilities ............................................................................. 6 Lab cleanliness ............................................................................. 6 Laboratory Equipment ............................................................................. 7 Proper use of glassware ............................................................................. 8 Some techniques in lab experiments Heating, cooling and stirring ............................................................................ -
Pacs by Chemical Name (Mg/M3) (Pdf)
Table 4: Protective Action Criteria (PAC) Rev 25 based on applicable 60-minute AEGLs, ERPGs, or TEELs. Values are presented in mg/m3. August 2009 Table 4 is an alphabetical listing of the chemicals in the PAC data set. It provides Chemical Abstract Service Registry Numbers (CASRNs)1, PAC values, and technical information on the source of the PAC values. Table 4 presents all values for TEEL-0, PAC-1, PAC-2, and PAC-3 in mg/m3. The conversion of ppm to mg/m3 is calculated assuming 25 ºC and 760 mm Hg. The columns presented in Table 4 provide the following information: Heading Definition No. The ordered numbering of the chemicals as they appear in this alphabetical listing. Chemical Name The chemical name given to the PAC Development Team. CASRN The Chemical Abstract Service Registry Number for this chemical. TEEL-0 This is the threshold concentration below which most people will experience no adverse health effects. This PAC is always based on TEEL-0 because AEGL-0 or ERPG-0 values do not exist. PAC-1 Based on the applicable AEGL-1, ERPG-1, or TEEL-1 value. PAC-2 Based on the applicable AEGL-2, ERPG-2, or TEEL-2 value. PAC-3 Based on the applicable AEGL-3, ERPG-3, or TEEL-3 value. Source of PACs: Technical comments provided by the PAC development team that TEEL-0, PAC-1, indicate the source of the data used to derive PAC values. Future efforts PAC-2, PAC-3 are directed at reviewing, revising, and enhancing this information. -
Download (7Mb)
A Thesis Submitted for the Degree of PhD at the University of Warwick Permanent WRAP URL: http://wrap.warwick.ac.uk/139966 Copyright and reuse: This thesis is made available online and is protected by original copyright. Please scroll down to view the document itself. Please refer to the repository record for this item for information to help you to cite it. Our policy information is available from the repository home page. For more information, please contact the WRAP Team at: [email protected] warwick.ac.uk/lib-publications I A STUDY OF OLFACTORY MECHANISMS by DAVID JAMES SQUIRRELL, BSc. A thesis submitted for the degree of Doctor of Philosophy in the Department of Chemistry and Molecular Science at the University of Warwick December. 1978 I i CONTE NTS PAGE CHAPTER 1 INTRODUCTION: THE VERTEBRATE OLFACTORY SYSTEM 1 1.1 Morphology 1 i ) Macroscopic 1 11 ) Microscopic 5 a) Olfactory neurons 7 b) Cilia 9 c) Mucus 10 d) Supporting cells 11 e) Basal cells 11 f) Axons 12 g) Contacts between cells 12 h) The lamina propria 13 ili) Cell dynamics in the olfactory epi thelium 14 Î V ) Experimentally induced degeneration and subsequent regeneration of the olfactory epithelium 15 1.2 Epi thelium 17 i ) The electro-olfactogram or EOG 19 i i ) Pos i t i ve EOG's 31 ili) Frequency of occurence of the various types of EOG 33 iv) Cellular origins of slow potentials in the olfactory epithelium 34 V) Ionic mechanisms 36 vi ) Generator currents in the olfactory epithelium 37 Vi i ) The site of transduction 41 1.3 Pp-~essing of Olfactory Information 43 -
Synthesis of Peptides with Hydroxamic Acid Side Chain Appendages
University of Louisville ThinkIR: The University of Louisville's Institutional Repository Electronic Theses and Dissertations 12-2003 Synthesis of peptides with hydroxamic acid side chain appendages. Yingchuan Susan Sun 1975- University of Louisville Follow this and additional works at: https://ir.library.louisville.edu/etd Recommended Citation Sun, Yingchuan Susan 1975-, "Synthesis of peptides with hydroxamic acid side chain appendages." (2003). Electronic Theses and Dissertations. Paper 1407. https://doi.org/10.18297/etd/1407 This Master's Thesis is brought to you for free and open access by ThinkIR: The University of Louisville's Institutional Repository. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of ThinkIR: The University of Louisville's Institutional Repository. This title appears here courtesy of the author, who has retained all other copyrights. For more information, please contact [email protected]. SYNTHESIS OF PEPTIDES WITH HYDROXAMIC ACID SIDE CHAIN APPENDAGES By Yingchuan Susan Sun B.S., China Pharmaceutical University, 1997 A Thesis Submitted to the Faculty of the Graduate School of the University of Louisville in Partial Fulfillment of the Requirements for the Degree of Master of Science Department of Chemistry University of Louisville Louiville, Kentucky December, 2003 SYNTHESIS OF PEPTIDES WITH HYDROXAMIC ACID SIDE CHAIN APPENDAGES By Yingchuan Susan Sun A Thesis Approved on April 14, 2003 By the Following Thesis Committee: Arno F. Spatola (deceased) Thesis Director Chairman ii Copyright 2003 by Yingchuan Susan Sun All rights reserved DEDICATION This thesis is dedicated to my graduate advisor Dr. Arno Spatola who spent his whole life in teaching me and other students principles of chemical science III ACKNOWLEDGEMENTS The author would like to express her gratitude and appreciation to her mentor, Dr. -
Syntheses and Therapeutic Potential of Hydroxamic Acid Based Siderophores and Analogues
Cf”, Rev. 1989, 89. 1563-1579 1563 Syntheses and Therapeutic Potential of Hydroxamic Acid Based Siderophores and Analogues MARVIN J. MILLER Department of Chemistry, Univ6rslfy of Notre Dam, Notre Dame. Indiana 46556 Received March 9, 1989 (Revised Manuscript Received June 15. 1989) Contenfs I. Introduction 1563 11. Synthetic Design and Synthesis of SMerophore 1564 Components A. Simple Hydroxamates 1565 B. Siderophores Containing 1566 1-Amino-w-(hydroxyamino)alkanes C. More Complex Amino Acid Containing 1567 HydroxamatbBased Siderophores and Analogues D. Total Syntheses of Hydroxamate Amino 1569 Acid Based Sierophores and Analogues 111. Siderophores and Siderophore Derivatives as 1575 Antibiotics Marvin J. Miller was born on Jan 29, 1949, in Dickinson. ND. His interest in science was greatly stimulated at Assumption Abbey Prep, a Benedictine monastic high school in Richardton, ND. Un- I. Infroducflon dergraduate research with Professor S. Peter Pappas at North Dakota State University in Fargo. increased his fascination with Iron has played an essential role in the evolution of science, especially organic chemistry. Further studies during his nearly every form of life on earth. Although iron is one Ph.D. work with Professor G. Marc Loudon at Cornell and an NIH postdoctoral position with Professor Henry Rapoport at Ee&eley of the most abundant elements on the planet, its pivotal solidified an interest in bioorganic chemistry. Since joining the role depended on the development of effective methods faculty at #m University of Notre Dame in 1977, Dr. Miller has been for its assimilation. Ionic forms of iron, especially an A. P. Sloan Fellow, an NIH research career development iron(III), its most common state, are very insoluble awardee, and a Visiting Fellow at #m Australian National University. -
2020 Emergency Response Guidebook
2020 A guidebook intended for use by first responders A guidebook intended for use by first responders during the initial phase of a transportation incident during the initial phase of a transportation incident involving hazardous materials/dangerous goods involving hazardous materials/dangerous goods EMERGENCY RESPONSE GUIDEBOOK THIS DOCUMENT SHOULD NOT BE USED TO DETERMINE COMPLIANCE WITH THE HAZARDOUS MATERIALS/ DANGEROUS GOODS REGULATIONS OR 2020 TO CREATE WORKER SAFETY DOCUMENTS EMERGENCY RESPONSE FOR SPECIFIC CHEMICALS GUIDEBOOK NOT FOR SALE This document is intended for distribution free of charge to Public Safety Organizations by the US Department of Transportation and Transport Canada. This copy may not be resold by commercial distributors. https://www.phmsa.dot.gov/hazmat https://www.tc.gc.ca/TDG http://www.sct.gob.mx SHIPPING PAPERS (DOCUMENTS) 24-HOUR EMERGENCY RESPONSE TELEPHONE NUMBERS For the purpose of this guidebook, shipping documents and shipping papers are synonymous. CANADA Shipping papers provide vital information regarding the hazardous materials/dangerous goods to 1. CANUTEC initiate protective actions. A consolidated version of the information found on shipping papers may 1-888-CANUTEC (226-8832) or 613-996-6666 * be found as follows: *666 (STAR 666) cellular (in Canada only) • Road – kept in the cab of a motor vehicle • Rail – kept in possession of a crew member UNITED STATES • Aviation – kept in possession of the pilot or aircraft employees • Marine – kept in a holder on the bridge of a vessel 1. CHEMTREC 1-800-424-9300 Information provided: (in the U.S., Canada and the U.S. Virgin Islands) • 4-digit identification number, UN or NA (go to yellow pages) For calls originating elsewhere: 703-527-3887 * • Proper shipping name (go to blue pages) • Hazard class or division number of material 2.