Nobel Prize Biography
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Curriculum Vitae, Nils G. Walter, Dr. Ing. (Chemistry)
Curriculum Vitae, Nils G. Walter, Dr. Ing. (Chemistry) Department of Chemistry, Rm. 2405 Phone: (734) 615-2060 930 N. University Ave. FAX: (734) 647-4865 University of Michigan E-mail: [email protected] Ann Arbor, MI 48109-1055 http://singlemolecule.lsa.umich.edu http://sites.lsa.umich.edu/walter-lab https://rna.umich.edu PROFESSIONAL EXPERIENCE FACULTY 2020-present Faculty Director of the Microscopy Core in the Biomedical Research Core Facilities (BRCF) 2018 Sabbatical Visitor, Chan Zuckerberg Biohub, San Francisco 2017-present Francis S. Collins Collegiate Professor of Chemistry, Biophysics, and Biological Chemistry, College of Literature, Science and the Arts 2016-present Founding Co-Director, Center for RNA Biomedicine, U. of Michigan; awarded a 5-year $10.2M Biosciences Initiative Award in 2018 to further build this grassroots, 150-faculty member effort 2016-present Professor of Biological Chemistry 2015-present Co-Director, Microfluidics in Biomedical Sciences Training Program 2015-present Associate Director, Michigan Post-baccalaureate Research Education Program (PREP) 2010-present Founding Director, Single Molecule Analysis in Real-Time (SMART) Center 2009-present Professor of Chemistry 2005-2009 Associate Professor of Chemistry 2006 Sabbatical Visitor, Harvard University, with Sunney Xie in Chemistry & Chemical Biology 2006 Distinguished Visitor, JILA, Boulder, with David Nesbitt 2002-2005 Dow Corning Assistant Professor of Chemistry 1999-2005 Assistant Professor of Chemistry 1999-present Member of the Biophysics (since 1999), Applied Physics (since 2000), Cellular & Molecular Biology (since 2001), and Chemical Biology (since 2005) Interdepartmental Graduate Programs University of Michigan, Ann Arbor POSTDOCTORATE 1996-1999 Postdoctoral Research Fellow with Prof. John M. Burke, University of Vermont; Subject: Biophysical Studies of the Hairpin Ribozyme 1995 Postdoctoral Research Fellow with Nobel laureate Prof. -
Interview with Melvin I. Simon
MELVIN I. SIMON (b. 1937) INTERVIEWED BY SHIRLEY K. COHEN May 24 and June 5, 2005 Melvin I. Simon ARCHIVES CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California Subject area Biology Abstract Interview in two sessions, May 24 and June 5, 2005, with Melvin I. Simon, Anne P. and Benjamin F. Biaggini Professor of Biological Sciences, emeritus, in the Division of Biology. Dr. Simon received his BS from City College of New York in 1959 and his PhD in biochemistry from Brandeis in 1963. After receiving his degree, he was a postdoctoral fellow with Arthur Pardee at Princeton for a year and a half and then joined the faculty of the University of California at San Diego. In 1978, Dr. Simon and his UCSD colleague John Abelson established the Agouron Institute in San Diego, focusing on problems in molecular biology. He (along with Abelson) joined the faculty of Caltech as a full professor in 1982, and he served as chair of the Biology Division from 1995 to 2000. http://resolver.caltech.edu/CaltechOH:OH_Simon_M In this interview, he discusses his education in Manhattan’s Yeshiva High School (where science courses were taught by teachers from the Bronx High School of Science), at CCNY, and as a Brandeis graduate student working working with Helen Van Vunakis on bacteriophage. Recalls his unsatisfactory postdoc experience at Princeton and his delight at arriving at UC San Diego, where molecular biology was just getting started. Discusses his work on bacterial organelles; recalls his and Abelson’s vain efforts to get UCSD to back a full-scale initiative in molecular biology and their subsequent founding of their own institute. -
Max Perutz (1914–2002)
PERSONAL NEWS NEWS Max Perutz (1914–2002) Max Perutz died on 6 February 2002. He Nobel Prize for Chemistry in 1962 with structure is more relevant now than ever won the Nobel Prize for Chemistry in his colleague and his first student John as we turn attention to the smallest 1962 after determining the molecular Kendrew for their work on the structure building blocks of life to make sense of structure of haemoglobin, the red protein of haemoglobin (Perutz) and myoglobin the human genome and mechanisms of in blood that carries oxygen from the (Kendrew). He was one of the greatest disease.’ lungs to the body tissues. Perutz attemp- ambassadors of science, scientific method Perutz described his work thus: ted to understand the riddle of life in the and philosophy. Apart from being a great ‘Between September 1936 and May 1937 structure of proteins and peptides. He scientist, he was a very kindly and Zwicky took 300 or more photographs in founded one of Britain’s most successful tolerant person who loved young people which he scanned between 5000 and research institutes, the Medical Research and was passionately committed towards 10,000 nebular images for new stars. Council Laboratory of Molecular Bio- societal problems, social justice and This led him to the discovery of one logy (LMB) in Cambridge. intellectual honesty. His passion was to supernova, revealing the final dramatic Max Perutz was born in Vienna in communicate science to the public and moment in the death of a star. Zwicky 1914. He came from a family of textile he continuously lectured to scientists could say, like Ferdinand in The Tempest manufacturers and went to the Theresium both young and old, in schools, colleges, when he had to hew wood: School, named after Empress Maria universities and research institutes. -
Hugh Huxley (1924-2013) Biophysicist Who Established the Mechanism of Muscle Contraction
COMMENT OBITUARY Hugh Huxley (1924-2013) Biophysicist who established the mechanism of muscle contraction. n a career spanning more than 65 years, salt solutions that extract myosin removed how calcium ions regulated cross-bridge Hugh Huxley achieved his lifelong only the optically dense A-bands (another interaction. In 1970, using intense X-ray ambition of understanding how eureka moment). Their 1953 Nature paper, synchrotron radiation, Huxley began time- Imuscles contract. together with earlier X-ray work, provided resolved studies of cross-bridge movement. Huxley, who died on 25 July after a heart the key evidence for the ‘sliding filament’ Huxley’s move in 1988 to Brandeis Univer- attack, was born in 1924 in Cheshire, UK, model of muscle contraction. sity in Waltham, Massachusetts, as director and studied physics at Christ’s College at the of the Rosenstiel Basic Medical Sciences University of Cambridge, UK. His education Research Center, gave him access to even was interrupted by service in the Royal Air more powerful X-ray sources, particularly Force from 1943 to 1947, testing height-to- at Argonne National Laboratory in Illinois. surface (H2S) radar — a ground-scanning Improved detectors with high-sensitivity system used by bomber aircraft. There, charge-coupled devices (used in digital he learned the importance of doing work cameras) enabled him to collect in milli- himself, and experimenting with electrical seconds data that would have taken hours ADDIS/PHOTOFUSION PETE and mechanical devices became a lifetime when he started out. With the atomic struc- passion. Huxley was able to fix a wildly tures of actin and the myosin cross-bridge, inaccurate version of H2S developed for east along with other evidence, he wrote in the Asia by switching from a voltage-controlled European Journal of Biochemistry in 2004 that display system, in which overheating was a he finally had direct evidence for the type of problem, to a current-controlled system. -
Curriculum Vitae
1 CURRICULUM VITAE David Ross Engelke EDUCATION 1974 University of Wisconsin, Madison, B.S. (Biochemistry) 1979 Washington University, St. Louis, Ph.D. (Biological Chemistry) Advisor: Robert G. Roeder POSTDOCTORAL TRAINING 1979-1983 Postdoctoral Fellow, Department of Chemistry, University of California, San Diego, La Jolla, California, Advisor: John Abelson ACADEMIC APPOINTMENTS 1983-1989 Assistant Professor, Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 1989-1996 Associate Professor, Department of Biological Chemistry, The University of Michigan 1996-2015 Professor, Department of Biological Chemistry, University of Michigan 1995 Interim Director, Medical Scientist Training Program 1995-1998 Director, Cellular and Molecular Biology Ph.D. Program, The University of Michigan 1998-2007 Founding Director, Program in Biomedical Sciences, The University of Michigan 2000-2007 Assistant Dean, Graduate and Postdoctoral Studies, UM Medical School 2008-2012 Associate Dean, H. H. Rackham School of Graduate Studies University of Michigan 2009-2010 Founding Director, Michigan Postbaccalaureate Research Education Program (PREP) 2010-2015 Associate Director, Michigan PREP 2013-2015 Chair, Department of Biological Chemistry, University of Michigan 2015-present Professor of Chemistry, University of Colorado Denver | Anschutz Professor of Biochemistry and Molecular Genetics, UC Denver | Anschutz Dean of the Graduate School, UC Denver | Anschutz CONSULTING POSITIONS 1989-1994 Parke-Davis 1990/91 Merck Inc. 1994 NeXstar, -
CURRENT TECHNOLOGY and RESOURCE NEEDS the Specific and Primary Agouronpurposes Are to Perform Research in the Sciences
The Agouron Institute GEOBIOLOGY CURRENT TECHNOLOGY and RESOURCE NEEDS The specific and primary AGOURONpurposes are to perform research in the sciences INSTITUTEand in mathematics, to disseminate the results obtained therefrom, all to benefit mankind. Cover photo: Phototrophic sulfur and non-sulfur bacteria in an enrichment from a microbial mat reveal part of the enormous diversity of microorganisms. © 2001 The Agouron Institute 45 GEOBIOLOGY CURRENT TECHNOLOGY and RESOURCE NEEDS The Agouron Institute INTRODUCTION 3 GEOBIOLOGY: 5 Current Research General Overview 5 Advances in Probing The Rock Record 6 Advances in Molecular Biology and Genomics 9 Current Research Directions 11 Questions of What and When: Detecting Life in the Geologic Record 12 Molecular Fossils 12 Morphological Fossils 14 Isotopic Signatures 16 Question of Who and How: Deciphering the Mechanisms of Evolution 18 Genetic Diversity 18 Microbial Physiology 20 Eukaryotic Systems 23 Experimental Paleogenetics 25 GEOBIOLOGY: Resource Needs 29 An Intensive Training Course in Geobiology 30 A Postdoctoral Fellowship Program in Geobiology 31 Support for Specific Research Projects 32 REFERENCES 34 2 Agouron Institute had expanded considerably and had obtained additional funding from the NSF and the NIH. A group of molecular biologists and chemists were collaborating to exploit new technology in which synthetic oligonucleotides were used to direct specific mutations in genes. A crystallography group had been INTRODUCTION formed and they were collaborating with the molecular biologists to study the properties of the altered proteins. These were among the very first applications of the new technology to form what is now the very ith the discovery of recombi- large field of protein engineering. -
Francis Crick Personal Papers
http://oac.cdlib.org/findaid/ark:/13030/kt1k40250c No online items Francis Crick Personal Papers Special Collections & Archives, UC San Diego Special Collections & Archives, UC San Diego Copyright 2007, 2016 9500 Gilman Drive La Jolla 92093-0175 [email protected] URL: http://libraries.ucsd.edu/collections/sca/index.html Francis Crick Personal Papers MSS 0660 1 Descriptive Summary Languages: English Contributing Institution: Special Collections & Archives, UC San Diego 9500 Gilman Drive La Jolla 92093-0175 Title: Francis Crick Personal Papers Creator: Crick, Francis Identifier/Call Number: MSS 0660 Physical Description: 14.6 Linear feet(32 archives boxes, 4 card file boxes, 2 oversize folders, 4 map case folders, and digital files) Physical Description: 2.04 Gigabytes Date (inclusive): 1935-2007 Abstract: Personal papers of British scientist and Nobel Prize winner Francis Harry Compton Crick, who co-discovered the helical structure of DNA with James D. Watson. The papers document Crick's family, social and personal life from 1938 until his death in 2004, and include letters from friends and professional colleagues, family members and organizations. The papers also contain photographs of Crick and his circle; notebooks and numerous appointment books (1946-2004); writings of Crick and others; film and television projects; miscellaneous certificates and awards; materials relating to his wife, Odile Crick; and collected memorabilia. Scope and Content of Collection Personal papers of Francis Crick, the British molecular biologist, biophysicist, neuroscientist, and Nobel Prize winner who co-discovered the helical structure of DNA with James D. Watson. The papers provide a glimpse of his social life and relationships with family, friends and colleagues. -
The Annotated and Illustrated Double Helix
000_FrontMatter_DH_Double Helix 9/17/12 10:12 AM Page i s 000_FrontMatter_DH_Double Helix 9/17/12 10:12 AM Page ii Cambridge city center, early 1950s. Detail of a map published by W. Heffer & Sons. 000_FrontMatter_DH_Double Helix 9/17/12 10:12 AM Page iii JAMES D. WATSON THE ANNOTATED AND ILLUSTRATED DOUBLE HELIX Edited by Alexander Gann & Jan Witkowski SIMON & SCHUSTER New York London Toronto Sydney New Delhi 000_FrontMatter_DH_Double Helix 9/27/12 3:59 PM Page iv s Simon & Schuster 1230 Avenue of the Americas New York, NY 10020 Copyright © 1968 by James D. Watson Copyright renewed © 1996 by James D. Watson New annotations, illustrations, and appendixes Copyright © 2012 by Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. All rights reserved, including the right to reproduce this book or portions thereof in any form whatsoever. For information address Simon & Schuster Subsidiary Rights Department, 1230 Avenue of the Americas, New York, NY 10020 First Simon & Schuster hardcover edition November 2012 SIMON & SCHUSTER and colophon are registered trademarks of Simon & Schuster, Inc. For information about special discounts for bulk purchases, please contact Simon & Schuster Special Sales at 1-866-506-1949 or [email protected]. The Simon & Schuster Speakers Bureau can bring authors to your live event. For more information or to book an event, contact the Simon & Schuster Speakers Bureau at 1-866-248-3049 or visit our website at www.simonspeakers.com. Designed by Denise Weiss Manufactured in the United States of America 10 9 8 7 6 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Watson, James D., date. -
California Meetings
California Meetings An artist’s rendering of what the Archean earth looked like at the time of the rise of oxygen. The Birth of Oxygen John Abelson This presentation was given at a meeting of the American Academy, held at the University of California, San Diego, on November 17, 2006. John Abelson is George Beadle Professor of Biology, Emeritus, at the California Institute of Technology, Adjunct Professor of Biochemistry at the University of California, San Francisco, and the President of the Agouron Institute. He has been a Fellow of the American Academy since 1985. We take it for granted that our atmosphere thesis was, after the origin of life itself, the The closely linked evolution of photosyn- contains oxygen, but we and most other ani- most important development in the history thesis and the evolution of the atmosphere is mals would die within minutes if the oxygen of our planet. About twelve times as much perhaps the best example of the interdepen- was removed. It is not widely appreciated energy is derived from the aerobic metabo- dence of biological and geological processes. that for half of the earth’s history there was lism of a molecule of glucose as the energy In chronicling the rise of oxygen, I will ½rst virtually no oxygen in the atmosphere. Oxy- obtained from anaerobic metabolism. With- describe photosynthesis and its origins. Then gen appeared 2.45 billion years ago, and it has out the invention of oxygenic photosynthe- I will turn to a discussion of the state of the been present ever since–though not always sis, multicellular organisms could not have earth and its atmosphere before and during at its present level of 21 percent. -
What Makes a Great Lab?
COMMENT 1826 and acquired international renown. It attracted students from all over Europe and earned Liebig a reputation as a ‘chemist breeder’. His lab was an early example of the research and teaching establishments that SOURCE: LMB ARCHIVE LMB SOURCE: made the German universities the envy of many. It began as a single room, with a fire in the middle surrounded by work benches. Liebig’s work on the compositions of chemical substances and their reactions was outstand- ing, and his focus on agricultural, industrial and biological issues gave his research a highly topical flavour. He trained his protégés carefully, espe- cially in qualitative analysis. Students flocked to him, with the result that European chem- istry during the middle of the nineteenth century bore a distinctly Liebigian flavour as his students moved to influential positions elsewhere. The identification of state-of-the- art problems and the training of students to solve them characterize his achievements. Liebig’s initiative was widely adapted in the natural and biomedical sciences throughout Max Perutz, James Watson, John Kendrew and Francis Crick talk to a BBC presenter (centre) about the German university system. their Nobel prizes in 1962. Training was also part of the brief of physiologist Ivan Pavlov (1849–1936), but he brought his own organizational genius to bear on the ‘physiology factory’ that he masterminded in St Petersburg, Russia, What makes famously studying dogs. He adapted aspects of manufacturing to the production of sci- entific knowledge. Pavlov’s staff were among the first to specialize in different tasks: surgi- a great lab? cal, chemical, dog handling. -
Andrew F. Huxley 282
EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F. -
Identification of Five Putative Yeast RNA Helicase Genes
Proc. Nati. Acad. Sci. USA Vol. 87, pp. 1571-1575, February 1990 Biochemistry Identification of five putative yeast RNA helicase genes (gene family/degenerate oligonucleotides/polymerase chain reaction) TIEN-HsIEN CHANG, JAIME ARENAS, AND JOHN ABELSON Division of Biology 147-75, California Institute of Technology, Pasadena, CA 91125 Contributed by John Abelson, December 5, 1989 ABSTRACT The RNA helicase gene family encodes a characterized Drosophila gene vasa (7); yeast genes TIFI, group of eight homologous proteins that share regions of TIF2, and MSSJ16 (8, 9); as well as mouse PLIO gene (10). sequence similarity. This group of evolutionarily conserved Based on the amino acid sequence alignments of these pro- proteins presumably all utilize ATP (or some other nucleoside teins, an additional gene family, the RNA helicase gene family, triphosphate)' as an energy source for unwinding double- consisting of both established and putative RNA helicase stranded RNA. Members of this family have been implicated in genes, was defined (11). Although the sequence conservation a variety of physiological functions in organisms ranging from is spread out over a stretch of 420 amino acids, several Escherichia coli to human, such as translation initiation, mito- sequence elements are especially striking. The sequence D X4 chondrial mRNA splicing, ribosomal assembly, and germinal A X4 G K T, found in all eight proteins, is typical for the A line cell differentiation. We have applied polymerase chain motif of ATP binding proteins (12-14). The D E A D reaction technology to search for additional members of the box, (V/I) L D E A D X2 L, on the other hand, represents a RNA helicase family in the yeast Saccharomyces cerevisiae.