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Cold Spring Harbor Symposia on Quantitative Biology COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XXXVII COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 LIST OF PREVIOUS VOLU.~IES Vo]ume i (1933) Surface Phenomena Volume II (1934) Aspects of Growth Volulne III (1935) Photochemical Reactions Volume IV (1936) Excitation Phenomena Volume V (1937) Internal Secretions Volume VI (1938) Protein Chemistry Volume VII (1939) Biological Oxidations Volume VIH (1940) Permeability and the Nature of Cell Membranes Volume IX (1941) Genes and Chromosomes. Structure and Organization Volume X (1942) The Relation of Hormones to Development Volume XI (1946) Heredity and Variation in Microorganisms Volume XII (1947) Nucleic Acids and Nucleoproteins Volume XIII (1948) Biological Applications of Tracer Elements Volume XIV (1949) Amino Acids and Proteins Volume XV (1950) Origin and Evolution of Man Volume XVI (1951) Genes and Mutations Volume XVII (1952) The Neuron Volume XVIII (1953) Viruses Volume XIX (1954) The Mam,nalian Fetus: Physiological Aspects of Development Volume XX (1955) Population Genetics: The Nature and Causes of Genetic Variability in Population Volume XXI (1956) Genetic Mechanisms: Structure and Function Volume XX[I (1957) Population Studies: Animal Ecology and Demography Volume XXIII (1958) Exchange of Genetic 3Iatcrial: Mechanism and Consequences Volume XXIV (1959) Genetics and Twentieth Century Darwinism Volume XXV (1960) Biological Clocks Volume XXV [ (1961 ) Cellular Regulatory l~Ieehanisms Volume XXVII (1962) Basic Mechanisms in Animal Virus Biology Volume XXVIII (1963) Synthesis and Structure of Macro,nolecules Volume XXIX (1964) Human Geuetics Volume XXX (1965) Sensory Receptors Volume XXXI (1966) The Genetic Code Volume XXXII (1967) Antibodies, Volume XXXI[I (1968) P~eplication of DNA in Microorganisms Volumc XXXIV (1969) The Mechanism of Protein Synthesis Volume XXXV (1970) Transcription of Genetic Material Volume XXXVI (1971) Structure and Function of Proteins at the Three-di,nensional Level COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XXXVII The Mechanism of Muscle Contraction COLD SPRING HARBOR LABORATORY 1973 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XXXVH 9 1973by The Cold Spring Harbor Laboratory All rights reserved International Standard Book Number 0-87969-036-4 (clothbound) Library of Congress Catalog Card Number 34-8174 P~nted in the United States of America The Symposium Volumes are published by The Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, and may be purchased directly or through booksellers. Price of Volume 37--$30.00 (inc. postage). Price subject to change without notice. Symposium Participants ABBOTT, ROGER H., Department of Zoology, ARC BRAY, DEN.'~IS, MRC Laboratory of Molecular Unit of Muscle Mechanisms, Oxfi)rd, England. Biology, Cambridge, England. ADELSTEIN, ROBERT S., National Heart and Lung BREMEL, ROBERT D., Department of Biochemistry, Institute, NIH, Bethesda, Md. St. Louis University School of Medicine, APRIL, ERNEST W., Department of Anatomy, St. Louis. College of Physicians and Surgeons, Columbia BULLARD, BELINDA, Department of Zoology, University, New York. Oxford University, Oxford, England. ARNDT, [SABELLE 0., Department of Anatomy, BURKE, MORRIS, Department of Biology, Johns University of Pennsylvania, Philadelphia. Hopkins University, Baltimore. Avis, VANCE R., Department of Physiology, Bt:TLER, THOMAS M., Department of' Animal University of California, Los Angeles. Biology, University of Pennsylvania Schoo] of BARANY, GEORGE, Department of Biochemistry, Veterinary Medicine, Philadelphia. The Rockefeller University, New York. BUZASII, ELIZABETII, Department of Biology, B~RXNY, KATE, Department of Physical Chemistry, University of Connecticut, Storrs. Institute for Muscle Disease, Inc., New York. CARLSON, FRA.~CIS l)., Department of Biophysics, B~-R~,NY, MIClIAEL,Department of Physical Chem- Johns Hopkins University, Baltimore. istry, Institute for Muscle Disease, |nc., CARNEY, HOWARD, JR., Department of Bio- New York. physics, Johns Hopkins University, Balti- BARTON, JA.'~ICE S., Department of Biology, more. Johns Hopkins University, Baltimore. CASPAR, DONALD L. O., Children's Cancer Research BASK1N, RONXLD J., Department of Zoology, Foundation, Boston. University of California, Davis. CIIEU.NG, HERBERT C., Department of Engineering BAss, BERL G., Department of Physiology, Biophysics, University of Alabama Medical Einstein College of Medicine, Bronx, New Center, Birmingham. York. CHOWRASHI,PROKAS]I K., Department of Anatomy, BENSON, ELLIS S., Department of Laboratory University of Pennsylvania Medical School, Medicine, University of Minnesota, Minnea- Philadelphia. polis. COItEN, CAROLYN, Children's Cancer Research BERNARDINI, [SA, Laboratory of Structural and Foundation, Boston. Molecular Biology, Children's Cancer Re- COLLINS, Jom~" H., Department of Muscle Research, search Foundation, Boston. Boston Biomedical Research Institute, Boston. BHATNAGAR, GI[Ot'AL, Department of Muscle COOKE, ROGER, Departments of Biochemistry and ]~esearch, Boston Biomedical Research insti- Biophysics, University of California, San tute, Boston. Francisco. Bin6, N. A., Biochemistry Group, EStvSs Ldr~nd COSTANTIN, LEROY L., Department of Physiology University, Budapest, Hungary. and Biophysics, Washington University School BOLAND, RlCARDO, Department of Biochemistry, of Medicine, St. Louis. St. Louis University School of Medicine, St. CUNNINGHAM, BRUCE A., Department of Bio- Louis. chemistry, The Rockefeller University, New BON.~ER, ROBERT F., Department of Biophysics, York. Johns Hopkins University, Baltimore. CVRTIN, Nancy, Department of Animal Biology, BRA~DT, PIIILIr W., Department. of Anatomy, University of Pennsylvania School of Veterin- Columbia University, New York. ary Medicine, Philadelphia. vi SYMPOSIUM PARTICIPANTS DAVIES, ROBERT E., Department of Animal FISCHMAN, DONALD A., Department of Biology, Biology, University of Pennsylvania School of University of Chicago, Chicago. Veterinary Medicine, Philadelphia. FRASER, ALLAN, Department of Biophysics, Johns DAwsoN, JOAN, Department of Pharmacology, Hopkins University, Baltimore. University of Pennsylvania, Philadelphia. FRIEDMAN, ZVIEL, Department of Biochemistry, D'HAESE, JOCHEN, Department of Cytology and St. Louis University School of Medicine, St. Micromorphology, University of Bonn, Bonn, Louis. Germany. GAETJENS, ERIC, Department of Contractile Pro- DOUGLAS, WILLIAM B., JR., Department of teins, Institute for Muscle Disease, Inc., Physiology, Michigan State University, East New York. Lansing. GAUTHIER, GERALDINE, Laboratory of Electron DOW, JOCELYN W., MRC Laboratory of Molecular Microscopy, Wellesley College, Wellesley, Biology, Cambridge, England. Mass. DRABIKOWSKI, WITOLD, Department of Bio- GERGELY, JOHN, Department of Muscle Research, chemistry of Nervous Systems and Muscles, Boston Biomedical Research Institute, Boston. Nencki Institute of Experimental Biology, GIAMBALVO,ANTHONY, Department of Biophysics, Warsaw, Poland. State University of New York, Brooklyn. DREIZEN, PAUL, State University of New York, GIBnONS, IAN R., Pacific Biomedical Research Downstate Medical Center, Brooklyn. Center, University of Hawaii, Honolulu. EATON, BARBRA, Biochemistry Graduate Group, GOLDMAN, ROBERT, Department of Biology, Case University of Pennsylvania, Philadelphia. Western Reserve University, Cleveland, Ohio. *EBAsHI, SETSURO, Department of Pharmacology, GOLL, DARREL, Muscle Biology Group, Iowa State Faculty of Medicine, University of Tokyo, University, Ames. Tokyo, Japan. GRANT, ROBERT J., Department of Biological ECKSTEIN, FRITZ, Department of Chemistry, Sciences, Hunter College, New York. Max-Planck-Institut, Gottingen, Germany. GREASER, MARION, Muscle Biology Laboratory, EDWARDS, CttARLES, Department of Biological University of Wisconsin, Madison. Sciences, State University of New York, *HANsoN, JEAN, MRC Biophysics Unit, King's Albany. College, London, England. EISENBERC., BUE~DA, Department of Physiology, HARRINGTON, WILLIAMF., Department of Biology, University of California School of Medicine, Johns Hopkins University, Baltimore. Los Angeles. HARTSHORNE, DAVID J., Department of Chemistry EISENBERG, EVAN, National Heart and Lung and Biological Sciences, Carnegie Mellon Institute, NIH, Bethesda, Md. University, Pittsburgh. EISENBERG, ROBERT, Department of Physiology, HASELGROVE,JOHN, MRC Laboratory of Molecular University of California School of Medicine, Biology, Cambridge, England. Los Angeles. HERMAN, LAWRENCE, Department of Pathology, ELFVIN, MYRA, Department of Anatomy, Medical State University of New York, Downstate College of Pennsylvania, Philadelphia. Medical Center, Brooklyn. ELLIOTT, GERALD F., Department of Physics, HEUMANN, HANs-G~NTHER, Department of Zo- The Open University, Bletchley, England. ology, Lehrstuhl ffir Zellenlehre, Heidelberg, ELZINGA, MARSHALL, Boston Biomedical Research Germany. Institute, Boston. HEYWOOD, STUART, Department of Biology, ENDO, MAKOTO,Department of Biological Sciences, University of Connecticut, Storrs. Purdue University, Lafayette, Ind. HITCHCOCK, SARAH E., Department of Biology, EPPENBERGER, HANS M., Laboratory of Develop- Brandeis University, Waltham, Mass. mental Biology, Swiss Federal Institute of *HOLMES, KENNETH C., Department of Biophysics, Technology, Zurich, Switzerland. Max-Planck-Institut, Heidelberg, Germany. ETLINGER, JOSEPH, Department of Biophysics, HOLT, JOHN C., Department
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