Springer Nature 开放获取期刊列表 按学科分类，影响因子为2019年6月发布
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Revealing the Immune Perturbation of Black Phosphorus Nanomaterials to Macrophages by Understanding the Protein Corona
ARTICLE DOI: 10.1038/s41467-018-04873-7 OPEN Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona Jianbin Mo 1,2, Qingyun Xie3, Wei Wei 1,2 & Jing Zhao 1 The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. 1234567890():,; Here we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effect on macrophages. Using liquid chromatography tandem mass spectrometry, 75.8% of the proteins bound to BP quantum dots were immune relevant proteins, while that percentage for BP nanosheet–corona complexes is 69.9%. In particular, the protein corona dramatically reshapes BP nanomaterial–corona complexes, influenced cellular uptake, activated the NF-κB pathway and even increased cytokine secretion by 2–4-fold. BP nanomaterials induce immunotoxicity and immune per- turbation in macrophages in the presence of a plasma corona. These findings offer important insights into the development of safe and effective BP nanomaterial-based therapies. 1 State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210093, China. 2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. 3 Department of Orthopedics, Chengdu Military General Hospital, Chengdu -
Three Years of Stem Cell Research & Therapy
Locke et al. Stem Cell Research & Therapy 2013, 4:46 http://stemcellres.com/content/4/3/46 EDITORIAL Three years of Stem Cell Research & Therapy Philippa Locke1*, Timothy O’Brien2 and Rocky S Tuan3 Editorial A responsible and respected publisher This year we celebrate three years of publication of Stem Since 2000, BioMed Central has been a pioneer of the Cell Research & Therapy. In this short space of time, as open access publishing model. A member of the Com- the number of journals in the stem cell and regenerative mittee on Publication Ethics (COPE), BioMed Central medicine field has grown and continues to grow dramat- regularly reviews its editorial policies and processes to ically, Stem Cell Research & Therapy has become ensure that they meet the highest standards [4]. All of established as the destination for high quality open ac- the research published in Stem Cell Research & Therapy cess research into stem cell therapeutics. is thoroughly peer-reviewed and deposited in a number of open access archives to ensure its continual availabil- ity [5]. Why Stem Cell Research & Therapy? When submitting work to a journal, authors understand- Our international, multidisciplinary Editorial Board ’ ably wish to be assured of the journal s quality. So what As well as assisting in the review of manuscripts, the Stem Cell Research & Therapy makes the leading forum Stem Cell Research & Therapy Editorial Board offers in- for translational stem cell research? valuable guidance on the journal’s commissioned con- tent and development. The Editorial Board members reflect the diversity in the field, from basic scientists to Scope, indexing, and impact clinicians, including surgeons [6]. -
Ultra-Efficient Frequency Comb Generation in Algaas-On-Insulator
ARTICLE https://doi.org/10.1038/s41467-020-15005-5 OPEN Ultra-efficient frequency comb generation in AlGaAs-on-insulator microresonators ✉ Lin Chang1,7, Weiqiang Xie1,7 , Haowen Shu1,2,7, Qi-Fan Yang 3, Boqiang Shen 3, Andreas Boes 1,4, Jon D. Peters1, Warren Jin1, Chao Xiang1, Songtao Liu 1, Gregory Moille5, Su-Peng Yu6, Xingjun Wang2, ✉ Kartik Srinivasan 5, Scott B. Papp 6, Kerry Vahala 3 & John E. Bowers1 Recent advances in nonlinear optics have revolutionized integrated photonics, providing on- 1234567890():,; chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials feature much higher nonlinear coefficients and convenience in active integration, they have suffered from high waveguide losses that prevent the realization of efficient nonlinear processes on-chip. Here, we challenge this status quo and demonstrate a low loss AlGaAs-on-insulator platform with anomalous dispersion and quality (Q) factors beyond 1.5 × 106. Such a high quality factor, combined with high nonlinear coefficient and small mode volume, enabled us to demonstrate a Kerr frequency comb threshold of only ∼36 µW in a resonator with a 1 THz free spectral range, ∼100 times lower compared to that in previous semiconductor platforms. Moreover, combs with broad spans (>250 nm) have been generated with a pump power of ∼300 µW, which is lower than the threshold power of state-of the-art dielectric micro combs. A soliton-step transition has also been observed for the first time in an AlGaAs resonator. -
THE OA EFFECT: HOW DOES OPEN ACCESS AFFECT the USAGE of SCHOLARLY BOOKS? White Paper
springernature.com Illustration inspired by the work of Jean-Claude Bradley Open Research THE OA EFFECT: HOW DOES OPEN ACCESS AFFECT THE USAGE OF SCHOLARLY BOOKS? White paper Open Research: Journals, books, data and tools from: 2 The OA effect: How does open access affect the usage of scholarly books? springernature.com Contents Authors Foreword . 3 Christina Emery, Mithu Lucraft, Executive summary . 4 Agata Morka, Ros Pyne Introduction . 5 November 2017 Part 1: Quantitative findings . 6 Summary . 6 Downloads . 7 Citations and mentions . 11 Part 2: Qualitative findings . 13 Summary . 13 Reasons for publishing open access . 14 Experience of publishing open access . 15 The future of open access . 16 Discussion . 18 Conclusion and recommendations . 20 Acknowledgements . 22 Contacts . 23 About Springer Nature and OA books . 24 Appendices . 26 Appendix 1: Definitions and limitations . 26 Appendix 2: Methodology . 27 Appendix 3: Top 10 downloaded books . 29 Appendix 4: Interviewed authors and funders . 30 Appendix 5: Author questionnaire . 32 Appendix 6: Funder questionnaire . 33 Appendix 7: References . 34 This work is licensed under a Creative Commons Attribution International License (CC BY 4.0) The OA effect: How does open access affect the usage of scholarly books? springernature.com 3 Foreword Springer Nature was created in 2015, but from our earliest days as Springer, Palgrave Macmillan and Nature, we have been publishing monographs and long-form research for some 175 years. The changing environment for book publishing has created both opportunities and challenges for researchers and their funders, for publishers, and for the wider community of readers and educators. As a publisher, we have championed new models of scholarship, introducing ebooks in 2006, and our first open access (OA) book in 2011. -
Contextualizing Systems Biology Presuppositions and Implications of a New Approach in Biology Contextualizing Systems Biology
Martin Döring Imme Petersen Anne Brüninghaus Regine Kollek Contextualizing Systems Biology Presuppositions and Implications of a New Approach in Biology Contextualizing Systems Biology Martin Döring • Imme Petersen Anne Brüninghaus • Regine Kollek Contextualizing Systems Biology Presuppositions and Implications of a New Approach in Biology Martin Döring Imme Petersen University of Hamburg University of Hamburg Hamburg , Germany Hamburg , Germany Anne Brüninghaus Regine Kollek University of Hamburg University of Hamburg Hamburg , Germany Hamburg , Germany ISBN 978-3-319-17105-0 ISBN 978-3-319-17106-7 (eBook) DOI 10.1007/978-3-319-17106-7 Library of Congress Control Number: 2015944085 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. -
SUBMISSION from SPRINGER NATURE Making Plan S Successful
PLAN S IMPLEMENTATION GUIDANCE: SUBMISSION FROM SPRINGER NATURE Springer Nature welcomes the opportunity to provide feedback to the cOAlition S Implementation Guidance and contribute to the discussion on how the transition to Open Access (OA) can be accelerated. Our submission below focuses mainly on the second question posed in the consultation: Are there other mechanisms or requirements funders should consider to foster full and immediate Open Access of research outputs? Making Plan S successful: a commitment to open access Springer Nature is dedicated to accelerating the adoption of Open Access (OA) publishing and Open Research techniques. As the world’s largest OA publisher we are a committed partner for cOAlition S funders in achieving this goal which is also the primary focus of Plan S. Our recommendations below are therefore presented with the aim of achieving this goal. As a first mover, we know the (multiple) challenges that need to be overcome: funding flows that need to change, a lack of cooperation in funder policies, a lack of global coordination, the need for a cultural change in researcher assessment and metrics in research, academic disciplines that lack OA resources, geographic differences in levels of research output making global “Publish and Read” deals difficult and, critically, an author community that does not yet view publishing OA as a priority. While this uncertainty remains, we need the benefits of OA to be better described and promoted as well as support for the ways that enable us and other publishers to cope with the rapidly increasing demand. We therefore propose cOAlition S adopt the following six recommendations which we believe are necessary to deliver Plan S’s primary goal of accelerating the take-up of OA globally while minimising costs to funders and other stakeholders: 1. -
Nature: Communications
ARTICLE https://doi.org/10.1038/s41467-019-09736-3 OPEN Water quality improvements offset the climatic debt for stream macroinvertebrates over twenty years Ian P. Vaughan 1,2 & Nicholas J. Gotelli2 Many species are accumulating climatic debt as they fail to keep pace with increasing global temperatures. In theory, concomitant decreases in other stressors (e.g. pollution, fragmen- 1234567890():,; tation) could offset some warming effects, paying climatic debt with accrued environmental credit. This process may be occurring in many western European rivers. We fit a Markov chain model to ~20,000 macroinvertebrate samples from England and Wales, and demon- strate that despite large temperature increases 1991–2011, macroinvertebrate communities remained close to their predicted equilibrium with environmental conditions. Using a novel analysis of multiple stressors, an accumulated climatic debt of 0.64 (±0.13 standard error) °C of warming was paid by a water-quality credit equivalent to 0.89 (±0.04)°C of cooling. Although there is finite scope for mitigating additional climate warming in this way, water quality improvements appear to have offset recent temperature increases, and the concept of environmental credit may be a useful tool for communicating climate offsetting. 1 Cardiff School of Biosciences and Water Research Institute, Cardiff University, Cardiff CF10 3AX, UK. 2 Department of Biology, University of Vermont, Burlington, VT 05405, USA. Correspondence and requests for materials should be addressed to I.P.V. (email: [email protected]) NATURE COMMUNICATIONS | (2019) 10:1956 | https://doi.org/10.1038/s41467-019-09736-3 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-019-09736-3 n response to global climate change, species will either shift in Across a series of analyses using ~20–26,000 high-quality, stan- distribution as they track their preferred climate, adapt locally, dardised benthic macroinvertebrate samples collected from I 1,2 or decline in abundance ultimately to extinction . -
Tracking the Popularity and Outcomes of All Biorxiv Preprints
1 Meta-Research: Tracking the popularity and outcomes of all bioRxiv 2 preprints 3 Richard J. Abdill1 and Ran Blekhman1,2 4 1 – Department of Genetics, Cell Biology, and Development, University of Minnesota, 5 Minneapolis, MN 6 2 – Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, 7 MN 8 9 ORCID iDs 10 RJA: 0000-0001-9565-5832 11 RB: 0000-0003-3218-613X 12 13 Correspondence 14 Ran Blekhman, PhD 15 University of Minnesota 16 MCB 6-126 17 420 Washington Avenue SE 18 Minneapolis, MN 55455 19 Email: [email protected] 1 20 Abstract 21 The growth of preprints in the life sciences has been reported widely and is 22 driving policy changes for journals and funders, but little quantitative information has 23 been published about preprint usage. Here, we report how we collected and analyzed 24 data on all 37,648 preprints uploaded to bioRxiv.org, the largest biology-focused preprint 25 server, in its first five years. The rate of preprint uploads to bioRxiv continues to grow 26 (exceeding 2,100 in October 2018), as does the number of downloads (1.1 million in 27 October 2018). We also find that two-thirds of preprints posted before 2017 were later 28 published in peer-reviewed journals, and find a relationship between the number of 29 downloads a preprint has received and the impact factor of the journal in which it is 30 published. We also describe Rxivist.org, a web application that provides multiple ways 31 to interact with preprint metadata. 32 Introduction 33 In the 30 days of September 2018, four leading biology journals – The Journal of 34 Biochemistry, PLOS Biology, Genetics and Cell – published 85 full-length research 35 articles. -
Regenerative Medicine in China: Demands, Capacity, and Regulation Biao Cheng1,2, Shuliang Lu3 and Xiaobing Fu1,4*
Cheng et al. Burns & Trauma (2016) 4:24 DOI 10.1186/s41038-016-0046-8 REVIEW Open Access Regenerative medicine in China: demands, capacity, and regulation Biao Cheng1,2, Shuliang Lu3 and Xiaobing Fu1,4* Abstract Regenerative medicine (RM) is an emerging interdisciplinary field of research. Its clinical application focuses on the repair, replacement, and regeneration of cells, tissues, and organs by approaches including cell reprogramming, stem cell transplantation, tissue engineering, activating factors, and clone treatment. RM has become a hot point of research in China and other countries. China’s main and local governments have attached great importance to RM and given strong support in relevant policies and funding. About 3.5 billion RMB has been invested in this field. Since 1999, China has established about 30 RM centers and cooperates with many advanced countries in RM research and benefits from their cooperation. However, China needs to develop standards, regulations, and management practices suitable for the healthy development of RM. In this review, we focus on its great demand, capacity, and relative regulations. Keywords: Regenerative medicine, Stem cell, Tissue engineering, China Background In the past 20 years, the RM market has continued Annually, about 100 million Chinese patients will receive to grow in China and other countries such as the treatment by tissue repair and regeneration technologies USA, Europe, Japan, and Singapore. As the largest because of the sharp increase in various injuries, acci- developing country, China has impressed the world dents, and diseases of aging. However, the current para- with its findings in stem cells, tissue engineering, digm of “healing by scar tissue replacement,” regardless of active molecules, and gene therapy as well as its na- superficial tissues or visceral organs, is stagnating and is tional strategies and regulation of RM. -
Impact on Citations and Altmetrics Peter E. Clayson*1, Scott
1 The Open Access Advantage for Studies of Human Electrophysiology: Impact on Citations and Altmetrics Peter E. Clayson*1, Scott A. Baldwin2, and Michael J. Larson2,3 1Department of Psychology, University of South Florida, Tampa, FL 2Department of Psychology, Brigham Young University, Provo, UT 3Neuroscience Center, Brigham Young University, Provo, UT *Corresponding author at: Department of Psychology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL, US, 33620-7200. Email: [email protected] 2 Disclosure Michael J. Larson, PhD, is the Editor-in-Chief of the International Journal of Psychophysiology. Editing of the manuscript was handled by a separate editor and Dr. Larson was blinded from viewing the reviews or comments as well as the identities of the reviewers. 3 Abstract Barriers to accessing scientific findings contribute to knowledge inequalities based on financial resources and decrease the transparency and rigor of scientific research. Recent initiatives aim to improve access to research as well as methodological rigor via transparency and openness. We sought to determine the impact of such initiatives on open access publishing in the sub-area of human electrophysiology and the impact of open access on the attention articles received in the scholarly literature and other outlets. Data for 35,144 articles across 967 journals from the last 20 years were examined. Approximately 35% of articles were open access, and the rate of publication of open-access articles increased over time. Open access articles showed 9 to 21% more PubMed and CrossRef citations and 39% more Altmetric mentions than closed access articles. Green open access articles (i.e., author archived) did not differ from non-green open access articles (i.e., publisher archived) with respect to citations and were related to higher Altmetric mentions. -
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