DOCSLIB.ORG

Technical Guidance Notes for Implementation of Regulation (EC)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Technical Guidance Notes for Implementation of Regulation (EC) 1.3.2011 EN Official Journal of the European Union C 65/1 IV (Notices) NOTICES FROM EUROPEAN UNION INSTITUTIONS, BODIES, OFFICES AND AGENCIES EUROPEAN COMMISSION COMMUNICATION FROM THE COMMISSION TECHNICAL GUIDANCE NOTES FOR IMPLEMENTATION OF REGULATION (EC) No 689/2008 Publication made in accordance with Article 23 of Regulation (EC) No 689/2008 of the European Parliament and of the Council of 17 June 2008 concerning the export and import of dangerous chemicals (2011/C 65/01) TABLE OF CONTENTS Page 1. INTRODUCTION . 3 2. THE ROTTERDAM CONVENTION . 5 3. REGULATION (EC) No 689/2008 . 6 3.1. Article 1: OBJECTIVES . 7 3.2. Article 2: SCOPE . 7 3.3. Article 3: DEFINITIONS . 7 3.4. Article 4: DESIGNATION OF NATIONAL AUTHORITIES . 8 3.5. Article 5: PARTICIPATION OF THE EUROPEAN UNION IN THE CONVENTION . 8 3.6. Article 6: CHEMICALS SUBJECT TO EXPORT NOTIFICATION, CHEMICALS QUALIFYING FOR PIC NOTIFICATION, AND CHEMICALS SUBJECT TO THE PIC PROCEDURE . 8 3.7. Article 7: EXPORT NOTIFICATIONS FORWARDED TO THIRD COUNTRIES . 9 3.8. Article 8: EXPORT NOTIFICATIONS FROM THIRD COUNTRIES . 11 3.9. Article 9: INFORMATION ON EXPORT AND IMPORT OF CHEMICALS . 11 3.10. Article 10: PARTICIPATION IN THE PIC NOTIFICATION PROCEDURE . 12 3.11. Article 11: INFORMATION TO BE SUBMITTED TO THE PIC SECRETARIAT ON CHEMICALS NOT QUALIFYING FOR PIC NOTIFICATION . 12 3.12. Article 12: OBLIGATIONS IN RELATION TO IMPORTS OF CHEMICALS . 12 3.13. Article 13: OBLIGATIONS IN RELATION TO EXPORTS OF CHEMICALS OTHER THAN EXPORT NOTIFICATION . 13 C 65/2 EN Official Journal of the European Union 1.3.2011 Page 3.14. Article 14: EXPORTS OF CERTAIN CHEMICALS AND ARTICLES CONTAINING CHEMICALS 16 3.15. Article 15: INFORMATION ON TRANSIT MOVEMENTS . 16 3.16. Article 16: INFORMATION TO ACCOMPANY EXPORTED CHEMICALS . 16 3.17. Article 17: OBLIGATIONS OF MEMBER STATES AND EXPORTERS FOR CONTROLLING IMPORT AND EXPORT . 19 3.18. Article 18: PENALTIES . 20 3.19. Article 19: INFORMATION EXCHANGE . 20 3.20. Article 20: TECHNICAL ASSISTANCE . 20 3.21. Article 21: MONITORING AND REPORTING . 20 3.22. Article 22: UPDATING ANNEXES . 21 3.23. Article 23: TECHNICAL NOTES FOR GUIDANCE . 21 3.24. Article 24: COMMITTEE . 21 4. THE EUROPEAN DATABASE ON EXPORT AND IMPORT OF DANGEROUS CHEMICALS . 21 5. EXAMPLES . 23 ANNEX 1 — Annex I to Regulation (EC) No 689/2008 of the European Parliament and of the Council 29 ANNEX 2 — Annex II to Regulation (EC) No 689/2008 . 42 ANNEX 3 — Annex V to Regulation (EC) No 689/2008 . 44 ANNEX 4 — Flow charts on the main procedures . 45 ANNEX 5 — Overview of exporters’ main tasks in order to comply with Regulation (EC) No 689/2008 49 ANNEX 6 — List of recommended languages for the labelling of exports to certain countries . 50 ANNEX 7 — List of Designated National Authorities for Regulation (EC) No 689/2008 . 55 ANNEX 8 — List of OECD countries to which waiver for explicit consent could be applied . 61 DISCLAIMER This Guide does not create any new legislative rules. It reflects the Commission’s understanding of Regu­ lation (EC) No 689/2008 and the other legislation referred to. It does not create any new rights or obligations not provided for therein. It should be noted that, in any event, the binding interpretation of Union law is ultimately the role of the Court of Justice of the European Union. ABBREVIATIONS AND DEFINITIONS USED CLP Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 CoP Conference of the Parties DNA Designated National Authority EDEXIM European Database Export Import of Dangerous Chemicals EC European Community 1.3.2011 EN Official Journal of the European Union C 65/3 EEC European Economic Community EU European Union FAO Food and Agriculture Organization of the United Nations GHS Globally Harmonised System of Classification and Labelling Hazard Statement means a phrase assigned to a hazard class and category that describes the nature of the hazards of a hazardous substance or mixture, including, where appropriate, the degree of hazard OECD Organisation for Economic Cooperation and Development PCBs Polychlorinated biphenyls PIC Prior Informed Consent POPs Persistent organic pollutants Precautionary Statement means a phrase that describes recommended measure(s) to minimise or prevent adverse effects resulting from exposure to a hazardous substance or mixture due to its use or disposal R-phrases Phrases describing the risks arising from the dangers involved in using the substance REACH Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals RIN Reference Identification Number S-phrases Phrases describing safety requirements and emergency response procedures relating to the safe use of the substance TARIC Tarif Intégré de la Communauté — i.e., Integrated Tariff of the European Community TFEU Treaty on the Functioning of the European Union UNEP United Nations Environment Programme 1. INTRODUCTION The European Union’s chemical industry is one of the world’s largest chemical producers. Its products include a wide range of substances for a multitude of purposes. Some substances are dangerous to human health and/or the environment and must be used under controlled conditions. Certain chemicals manu­ factured for export and use in other countries are banned or severely restricted within the European Union. It is important to know how to store, transport, use and dispose of dangerous chemicals safely. It is also vital to know what to do in emergency situations, and how to treat medical and environmental problems quickly and effectively. However, in many countries, particularly developing countries, there is a lack of capacity to manage chemicals safely. Workers are often untrained in the proper use and disposal of dangerous chemicals. Governments and companies in these countries may not have appropriate storage and disposal facilities. They may lack knowledge of the hazards of a chemical and how to prevent harm to people and the environment. C 65/4 EN Official Journal of the European Union 1.3.2011 Regulation (EC) No 689/2008 of the European Parliament and of the Council of 17 June 2008 ( 1 ) concerning the export and import of dangerous chemicals is the latest in a series of measures over the years that seek to address this issue. It implements within the EU the Rotterdam Convention on the Prior Informed Consent Procedure (PIC) for certain hazardous chemicals and pesticides in international trade, with a view to protecting human health and the environment from potential harm and contributing to the environmentally sound use of such chemicals. The Regulation also implements a requirement of the Stockholm Convention on persistent organic pollutants, as it bans the export of chemicals identified as persistent organic pollutants in the Convention unless there are specific exemptions foreseen in the Stockholm Convention. It replaces Regulation (EC) No 304/2003 ( 2 ) of the European Parliament and of the Council. ( 3 ) Regulation (EC) No 689/2008 reaffirms the EU’s commitment towards ensuring proper control in the trade and use of dangerous chemicals at the global level, based on the principle that it should help to protect human health and the environment beyond its borders as well as within. The Regulation is based on Article 133 EC (now Article 207 TFEU) and Article 175 EC (now Article 192 TFEU), in order to reflect the impact of provisions on both trade and environmental issues. Regulation (EC) No 689/2008 includes a number of technical amendments to the operative provisions of Regulation (EC) No 689/2008 in light of experience with implementation to date. In particular, and in recognition of the difficulties caused by delays in obtaining responses to requests for explicit consent to import, a procedure is foreseen for allowing exports of certain chemicals to proceed on a temporary basis in the case where, despite all reasonable effort, no response is obtained from the importing country. The Regulation outlines the specific conditions required to allow such waivers and establishes relevant timelines. In addition, under certain conditions a waiver from the obligation to obtain explicit consent is provided for when exporting certain chemicals to countries that are members of the Organisation for Economic Cooperation and Development (OECD). The revised Regulation also enhances and extends the role of the Commission’s database, EDEXIM, by requiring that a system of codes be assigned to export notifications, import decisions, consents and waivers that are maintained in the database. In order to facilitate customs enforcement and reduce administrative burden, exporters are to quote these codes in their export declarations. The Regulation also maintains a number of provisions that go beyond the requirements of the Rotterdam Convention, in order to achieve a higher level of protection to human health and the environment. This Guide opens in section II with an introduction to the Rotterdam Convention, including its basic principles and mechanisms. This section includes a summary of the areas in which the EU Regulation goes beyond the requirements of the Convention. The Guide continues in section III with an article by article review of Regulation (EC) No 689/2008, in which the key requirements of each provision are clearly explained and the relationship between different provisions highlighted. Section IV then outlines the role of the Commission in the day-to-day implementation of the Regulation and in maintaining the EDEXIM database. Finally, section V provides some examples that demonstrate how the requirements of the Regu­ lation play out practically in a range of cases. The Annexes provide useful supplementary information. Annexes 1 through 3 reproduce Annexes I, II, and V of Regulation (EC) No 689/2008. Please note that Annex I to the Regulation is subject to regular updates and the most up-to-date version will be kept available at the Commission’s website at: http://edexim.jrc.ec.
Load more

Recommended publications
  • Programme Des Nations Unies Pour L'environnement Plan D'action Pour
    PROGRAMME DES NATIONS UNIES POUR L’ENVIRONNEMENT PLAN D’ACTION POUR LA MÉDITERRANÉE MED POL INVENTAIRE DES PCB ET DE NEUF PESTICIDES No. 156 de la Série des rapports techniques du PAM PNUE/PAM Athènes, 2004 Note: Les appellations employées dans ce document et la présentation des données qui y figurent n'impliquent de la part du PNUE/PAM aucune prise de position quant au statut juridique des pays, territoires, villes ou zones, ou de leurs autorités, ni quant au tracé de leurs frontières ou limites. Ce document a été établi dans le cadre du Projet FEM ‘’Détermination d’actions prioritaires pour la poursuite de l’élaboration et de la mise en œuvre du Programme d’actions stratégiques pour la mer Méditerranée’’ sous la coordination de M. Ante Baric, PhD, Directeur de projet. MED POL (Dr. Fouad Abousamra, Chargé de Programme MED POL) est responsable de la conception et de la préparation de ce document. M. Yves Guilbert a établi l’avant-projet du document qui a été revu par les experts du MED POL. Le document révisé a été envoyé aux pays pour observations et à nouveau revu par une réunion d’experts désignés par les gouvernements. Le document révisé a été approuvé par la réunion des coordonnateurs nationaux pour le MED POL, tenue à San Gemini (Italie) du 27 au 30 mai 2003. © 2004 Programme des Nations Unies pour l'environnement (PNUE/PAM) B.P. 18019, Athènes, Grèce. ISSN 1011-7148 paper. ISSN 1810-6218 online Le texte de la présente publication peut être reproduit en tout ou en partie à des fins pédagogiques et non lucratives sans autorisation spéciale de la part du détenteur du copyright, à condition de faire mention de la source.
    [Show full text]
  • Rodenticides - Kramer R.E
    ENVIRONMENTAL TOXICOLOGY AND HUMAN HEALTH – Vol. I - Rodenticides - Kramer R.E. and Baker R.C. RODENTICIDES Kramer R.E. and Baker R.C. Department of Pharmacology and Toxicology, University of Mississippi Medical Center, U.S.A. Keywords: Fluoroacetate, sodium monofluoroacetate, compound 1080, fluorocitrate, fluoroacetamide, compound 1081, 1,3-difluoro-2-propanol, DFP, thiourea, α- naphthylthiourea, ANTU, pyriminil, PNU, Vacor, bromethalin, vitamin D, cholecalciferol, ergocalciferol, norbormide, scillirosides, scillirosidin, glycosides, α- chlorohydrin, thallium, phosphorus, zinc phosphide, aluminum phosphide, phosphine, strychnine, anticoagulants, brodifacoum, bromadiolone, chlorophacinone, coumachlor, difenacoum, diphencoumarin, difethialone, diphacinone, flocoumafen, pindone, warfarin, vitamin K, mechanisms of action, toxicity, treatment; antidotes Contents 1. Introduction 2. Fluoroacetate derivatives 2.1. Sodium Monofluoroacetate 2.2. Fluoroacetamide 2.3. 1,3-Difluoro-2-propanol 3. Thiourea Rodenticides 3.1. α-Naphthylthiourea (ANTU) 3.2. Pyriminil 4. Bromethalin 5. Vitamin D-based rodenticides 6. Norbormide 7. Scilliroside 8. Alpha (α)-chlorohydrin 9. Thallium 10. Yellow phosphorus 11. Zinc phosphide 12. Strychnine 13. Anticoagulant rodenticides Glossary BibliographyUNESCO – EOLSS Biographical Sketches SAMPLE CHAPTERS Summary A rodenticide is defined as any compound used to kill rodents or other small animals. They are widely used, and as a class encompass a disparate group of compounds with differing structures and mechanisms of action.
    [Show full text]
  • Partial Agreement in the Social and Public Health Field
    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (85) 4 ON GUIDELINES TO REDUCE THE RISKS OF CONTAMINATION OF ANIMAL PRODUCTS FOR HUMAN CONSUMPTION BY RESIDUES WHICH MAY RESULT FROM THE USE OF PESTICIDES ON LIVESTOCK AND IN LIVESTOCK PREMISES (Adopted by the Committee of Ministers on 20 June 1985 at the 387th meeting of the Ministers' Deputies) (superseding Resolution AP (81) 2) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands, the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland and Switzerland, states which have participated in the public health activities pursued within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve a greater unity between its members and that this aim may be pursued by common action in the social and public health field; Having regard to the provisions of the Brussels Treaty, signed on 17 March 1948, by virtue of which Belgium, France, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland declared themselves resolved to strengthen the social ties by which they were already united; Having regard to the Protocol modifying and completing the Brussels
    [Show full text]
  • ANALGESIC EFFECTS of SCILLIROSIDE, PROSCILLARIDIN-A and TAXIFOLIN from SQUILL BULB (Urginea Maritima) on PAINS
    Digest Journal of Nanomaterials and Biostructures Vol. 5, No 2, May 2010, p. 457 – 465 ANALGESIC EFFECTS of SCILLIROSIDE, PROSCILLARIDIN-A and TAXIFOLIN FROM SQUILL BULB (Urginea maritima) on PAINS VAHDETTİN BAYAZİT*, VAHİT KONARa Muş Alparslan University, Faculty of Arts and Sciences, Department of Biology, 49100, Muş, Turkey aFırat University, Faculty of Sciences and Arts, Department of Biology, Elazığ,Turkey The aim of the present study was to assess the clinical efficacy of proscillaridin-A (C30H42O8), taxifolin (C15H12O7) and scilliroside ( C32H44O12 ) and safety of squill bulb (Urginea maritima) (L.) Baker extract on various pains of spontaneous volunteer patients. In this study, 250 patients were monitored in coats. The average age of these patients were between 40 and 74 years old. Of these 100 were male and 150 female patients. Also, 60 % of proscillaridin-A (C30H42O8), taxifolin (C15H12O7) and scilliroside ( C32H44O12 ) solution in pure glycerin was applied as external on the pain area.ASO, CRP and RF higher values of patiens were significantly decreased ( p < 0.05 and p < 0.01). Knee, joint, calf, hip, shoulder, upper back, low back (lumbago), tailbone and fibromyalgia paints of patients were significantly reduced (p < 0.05 and p < 0.01).Squill bulb constituents can reduce the musculoskeletal pains. (Received May 7, 2010; accepted May 14, 2010) Keywords: Squill bulb (Urginea maritima) (L.) Baker, scilliroside, taxifolin, proscillaridin-A, lumbago, fibromyalgia, pain 1. Introductıon Urginea maritima (Liliaceae) is cultivated in the Mediterranean area. It is used as a cardiotonic diuretic in Europe for the treatment of cardiac marasmus and edema. Squill (white sea onion) is a cardiotonic similar to digitalis.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2017/0208806 A1 Barton Et Al
    US 20170208806A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0208806 A1 Barton et al. (43) Pub. Date: Jul. 27, 2017 (54) MOLECULES HAVING PESTICIDAL Publication Classification UTILITY, AND INTERMEDIATES, (51) Int. Cl. COMPOSITIONS, AND PROCESSES, AOIN 4I/O (2006.01) RELATED THERETO AOIN 37/34 (2006.01) AOIN 37/20 (2006.01) (71) Applicant: Dow AgroSciences LLC, Indianapolis, C07C 31 7/28 (2006.01) IN (US) C07C32L/4 (2006.01) (52) U.S. Cl. (72) Inventors: Thomas Barton, Indianapolis, IN (US); CPC ............ A0IN 41/10 (2013.01); C07C317/28 Xin Gao, Carmel, IN (US); Jim (2013.01); C07C321/14 (2013.01); A0IN Hunter, Indianapolis, IN (US); Paul R. 37/20 (2013.01); A0IN 37/34 (2013.01) LePlae, Brownsburg, IN (US); William (57) ABSTRACT C. Lo, Fishers, IN (US); Joshodeep This disclosure relates to the field of molecules having Boruwa, Noida, IN (US); Raghuram pesticidal utility against pests in Phyla Arthropoda, Mol Tangirala, Bengaluru, IN (US); Gerald lusca, and Nematoda, processes to produce Such molecules, B. Watson, Zionsville, IN (US); John intermediates used in Such processes, compositions contain Herbert, Fishers, IN (US) ing Such molecules, and processes of using Such molecules and compositions against Such pests. These molecules and compositions may be used, for example, as acaricides, (73) Assignee: Dow AgroSciences LLC, Indianapolis, insecticides, miticides, molluscicides, and nematicides. This IN (US) document discloses molecules having the following formula (“Formula One”). (21) Appl. No.: 15/408,693 (22) Filed: Jan. 18, 2017 Related U.S. Application Data (60) Provisional application No. 62/286.684, filed on Jan.
    [Show full text]
  • The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification : 2004
    WHO Library Cataloguing-in-Publication Data World Health Organization. The WHO recommended classification of pesticides by hazard and guidelines to classification : 2004. 1.Pesticides - toxicity 2.Pesticides - classification 3.Hazardous substances - classification 4.Guidelines I.International Programme on Chemical Safety..II.Title. ISBN 92 4 154663 8 (NLM classification: WA 240) ISSN 1684-1042 © World Health Organization 2005 All rights reserved. Publications of the World Health Organization can be obtained from Marketing and Dissemination, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 2476; fax: +41 22 791 4857; email: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to Marketing and Dissemination, at the above address (fax: +41 22 791 4806; email: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by WHO to verify the information contained in this publication.
    [Show full text]
  • W©IR<[L[Q) [F{][E~Lll~ (Q)OO~[M~~U~Cawj
    WHO!VBC/87.949 W©IR<[L[Q) [F{][E~lLl~ (Q)OO~[M~~u~cawJ ~®©it(Q)1F ~O(Q)~~ ~!T1lcdl CCootl:rnij [Q)n~o~n(Q)!1i), , ., 1987 FOREWORD Since 1970 the Vector Biology and Control Division of WHO has. prepared, with the assistance of collaborators outside the Organization, a number of papers on vector control. The Expert Committee on Insecticides held in October 1974 (Technical Report Series No. 561) recommended that these documents - general reviews of the ecology and control of individual vector groups - should be continued and reviewed from time to time to provide workers with up-to-date practical information on the particular subject. In 1985, with the greater demand for this material for use as training and information guides by different categories of personnel. particularly in the deVeloping countries, it was decided to develo(J two separate series of these documents; an advanced series for M. Sc. students in medical entomology and professional staff, and a middle-level series for less specialized workers in the community. The advanced series will cover the relevant subject in more detail and at a higher technical level. It is believed that this type of information will assist vector control specialists to acquire the knowledge required for their daily work. In order to improve the value and usefulness of this guide, evaluation forms are attaChed, and users are requested to send the completed forms to the WHO Division of Vector Biology and Control in Geneva so that their comments may be taken into consideration when the guide is revised.
    [Show full text]
  • US 2018 / 0325105 A1 Nov
    US 20180325105A1 ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2018 /0325105 A1 VADAKEKUTTU et al. ( 43 ) Pub . Date : Nov. 15 , 2018 ( 54 ) AGRICULTURAL COMPPOSITIONS (52 ) U .S . CI. CPC .. .. .. .. AOIN 25 / 12 ( 2013 .01 ) ; C05D 9 / 00 ( 71 ) Applicants : Thankapan VADAKEKUTTU , (2013 . 01 ) ; C05G 3 / 02 ( 2013 .01 ) ; C05G Mumbai ( IN ) ; Arun Vitthal SAWANT, 370058 ( 2013 . 01 ) Mumbai ( IN ) ( 57 ) ABSTRACT The invention relates to an agricultural water disintegrable (72 ) Inventors : Thankapan VADAKEKUTTU , granular composition . More particularly , the invention Mumbai ( IN ) ; Arun Vitthal SAWANT, relates to a water disintegrable granular composition , where Mumbai ( IN ) the granules include at least one water insoluble crop nutrient or or algae or pesticidal active ingredient , and one ( 21 ) Appl . No . : 15 / 976 , 304 or more agrochemically acceptable excipient, whereby the granules have a bulk density of less than 1 . 5 gm /ml and hardness of at least 1 Newton . The invention further relates ( 22 ) Filed : May 10 , 2018 to a water disintegrable granular composition which includes at least one algae and at least one agrochemically ( 30 ) Foreign Application Priority Data acceptable excipient wherein granules have particles in the size range of 0 . 1 micron - 50 microns , granule size is in the May 10 , 2017 ( IN ) .. .. .. .. .. .. .. 201721016449 range of 0 . 1 mm to 6 mm and attrition resistance of the Jun . 21 , 2017 ( IN ) . .. .. .. .. .. .. .. .. .. 201721021720 granules are at least 50 % . Jul. 11 , 2017 ( IN ) .. .. .. .. .. 201721024425 Furthermore , the invention relates to a process of preparing Sep . 18 , 2017 ( IN ) . .. .. .. .. .. .. .. PCT / IN2017 /050408 the water disintegrable granular composition including one or more water insoluble crop nutrients or algae or the pesticidal active ingredients .
    [Show full text]
  • Substance Number Common Name Chemical Name CAS DOT SHHC
    2010 Right to Know Hazardous Substance List CAS Substance Common Name CAS Number Order DOT SHHC Sources Number Chemical Name 50-00-0 0946 # FORMALDEHYDE 1198 CA CO MU F4 1 2 3 4 5 6 7 8 15 17 18 19 20 FORMALDEHYDE 21 22 50-07-7 1307 # MITOMYCIN C 3077 CA 3 6 7 17 19 20 21 AZIRINO[2',3':3,4]PYRROLO[1,2-a]INDOLE-4,7-DIONE, 6-AMINO-8-[[(AMINOCARBONYL)OXY]METHYL]-1,1a,2,8,8a,8b- HEXAHYDRO-8a-METHOXY-5-METHYL-,(1aS,8S,8aR,8bS)- 50-14-6 2391 ERGOCALCIFEROL 2811 3 6 17 19 9,10-SECOERGOSTA-5,7,10(19),22-TETRAEN-3-OL, (3.beta.,5Z,7E,22E)- 50-29-3 0596 # DDT 2761 CA TE 1 2 3 4 5 6 7 8 17 20 21 BENZENE, 1,1'-(2,2,2-TRICHLOROETHYLIDENE)BIS[4-CHLORO- 50-31-7 1776 2,3,6-TBA 2769 3 14 17 BENZOIC ACID, 2,3,6-TRICHLORO- 50-32-8 0207 # BENZO(a)PYRENE 3077 CA MU 1 2 3 4 5 6 7 8 17 18 20 21 BENZO[a]PYRENE 51-03-6 3732 PIPERONYL BUTOXIDE 6 18 1,3-BENZODIOXOLE, 5-[[2-(2-BUTOXYETHOXY)ETHOXY]METHYL]-6-PROPYL- 51-21-8 1966 # 5-FLUOROURACIL TE 6 7 18 19 2,4(1H,3H)-PYRIMIDINEDIONE, 5-FLUORO- 51-28-5 2950 # 2,4-DINITROPHENOL 1320 R4 3 6 8 17 18 20 21 PHENOL, 2,4-DINITRO- Page 1 of 268 2010 Right to Know Hazardous Substance List CAS Substance Common Name CAS Number Order DOT SHHC Sources Number Chemical Name 51-75-2 1377 # NITROGEN MUSTARD 2810 CA MU TE 3 6 7 17 18 19 ETHANAMINE, 2-CHLORO-N-(2-CHLOROETHYL)-N-METHYL- 51-79-6 1986 # URETHANE 3077 CA MU TE 3 5 6 7 8 17 18 20 21 22 CARBAMIC ACID, ETHYL ESTER 51-83-2 2209 CARBACHOL CHLORIDE 6 19 ETHANAMINIUM, 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYL-, CHLORIDE 52-24-4 1515 # TRIS(1-AZIRIDINYL)PHOSPHINE SULFIDE CA 5 7 AZIRIDINE,
    [Show full text]
  • The WHO Recommended Classification of Pesticides by Hazard Was Approved by the 28Th World Health Assembly in 1975 and Has Since Gained Wide Acceptance
    WRO/PCS/96..3 ENGLISH ONLY I)istr.: LIMITED IPCS Internationat Programme on Chemical Safety THE WHO RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD and GUIDELINES TO CLASSIFICATION 1996-1997 United NatioasEiyizirnment Programme International Labour Organization World Health Organization Programme des Nations Unies pour Bureau international dii Trarnil Organisation Mondiale de In Sante I'Fnvironnemen( WHO/PCS/96. 3 ENGLISH ONLY Distr,: ENGLISH THE)~ HQ RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD and GUIDELINES TO CLASSIFICATION 1996-97 LI01iIIIW1(•i The WHO Recommended Classification of Pesticides by Hazard was approved by the 28th World Health Assembly in 1975 and has since gained wide acceptance. When it was published in the WHO Chronicle, 22 , 397-401 (1975), an annex, which was not part of the Classification, illustrated its use by listing examples of classification of some pesticidal active ingredients and their formulations. Later suggestions were made by Member States and pesticide registration authorities that further guidance should be given on the classification of individual pesticides. Guidelines were first issued in 1978, and have since been revised and reissued at 2-yearly intervals. The document is arranged as follows: Part I: The Classification as recommended by the World Health Assembly. This part is not subject to periodic review and the classification table and text can only be changed by resolution of the World Health Assembly. Part II: Guidelines to Classification. Individual products are classified in a series of tables, according to the oral or dermal toxicity of the technical product, and its physical state. The tables are subject to review periodically. The toxicity values are intended to be a guide only.
    [Show full text]
  • A Novel Mutation in VKORC1 and Its Effect on Enzymatic Activity in Japanese Warfarin-Resistant Rats
    Advance Publication The Journal of Veterinary Medical Science Accepted Date: 8 Sep 2012 J-STAGE Advance Published Date: 26 Sep 2012 Field of paper: toxicology Type of paper: full paper A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats Kazuyuki D. Tanaka1), Yusuke K. Kawai1), Yoshinori Ikenaka1), Tsunehito Harunari2), Tsutomu Tanikawa2), Shoichi Fujita1), and Mayumi Ishizuka1), 1)Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan 2)Technical Research laboratory, Ikari Corporation, Chiba, 260-0844, Japan Corresponding author: Dr. Mayumi Ishizuka, Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan, Tel:81-11-706-6949 / Fax:81-11-706-5105 e-mail: [email protected] Running head: VKOR OF WARFARIN RESISTANT RATS IN JAPAN 1 ABSTRACT Warfarin is a rodenticide commonly used worldwide. It inhibits coagulation of blood by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity. An inadequate supply of vitamin K blocks the production of prothrombin and causes hemorrhage. Recently, warfarin-resistant brown rats (Rattus norvegicus) were found around the Aomori area of Japan. There is no significant difference in the metabolic activity of warfarin in sensitive and resistant brown rats. To clarify the mechanism underlying warfarin resistance, we cloned the VKORC1 gene from rats and identified a novel substitution of arginine to proline at position 33 of the VKORC1 amino acid sequence. Then, we determined the differences in kinetics of VKOR activity between warfarin-resistant and sensitive rats.
    [Show full text]
  • Practice No. 5 Rodenticides
    Practice No. 5 Rodenticides Rodenticides: • Rodenticides are a group of pesticides which is primarily established for rodent control • There are strict rules how, when and where to use them. In spite of this they are common source of both wild and domestic animals´ poisoning and are also used for malicious intentions to harm • Poisoning is quite easy when baits with rodenticides are placed inconveniently at locations easily accessible for domestic animals esp. dogs and cats • In these animals is also possible to poison themselves by eating a dead rodent which died of rodenticide poisoning – so called secondary poisoning Division of rodenticides: • according to chemical character: - inorganic – zinc phosphide (and other phosphides), formerly arsenic or thallium - organic – natural (strychnine, scilliroside, vitamin D), synthetic (anticoagulants) • according to the route of administration: for eating, for drinking, for dusting, for fumigation • according to the type of action: one dose, cumulative/repetitive intake Zinc phosphide + aluminium phosphide • Phosphides are the only inorganic and single-shot used agents nowadays. Their use is in agriculture, they are not allowed in households. • They are very potent and absolutely non-selective and cause many accidental poisonings • Zinc phosphide is used as feed bait and aluminium phosphide is fumigated in closed spaces (stocks, stores). • Feed baits are made of grains impregnated by zinc phosphide or they are granules with active substance. Usually are not colourful! • Often cause poisonings
    [Show full text]