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Roy J. Carver Department of Biomedical Engineering 1 Roy J. Carver Department of Biomedical Engineering 1 Roy J. Carver Facilities Department Undergraduate Teaching Laboratories of Biomedical Seven dedicated undergraduate teaching laboratories are associated with the required and elective courses in Engineering biomedical engineering: the Bioimaging and Bioinformatics Laboratory; the Biomechanics and Biomaterials Laboratory; the Carver Biomechanics and Mechanobiology Laboratory; the Chair Carver Cellular Engineering Laboratory; the Carver Medical • Joseph M. Reinhardt Device Design Laboratory; the Senior Design Laboratory; and the Systems, Instrumentation, and Data Acquisition Undergraduate major: biomedical engineering (B.S.E.) Laboratory. Graduate degrees: M.S. in biomedical engineering; Ph.D. in biomedical engineering Bioimaging and Bioinformatics Faculty: https://bme.engineering.uiowa.edu/people Website: https://bme.engineering.uiowa.edu/ Laboratory The past half century has seen tremendous growth of The Bioimaging and Bioinformatics Laboratory provides technological activity in biology and medicine. As engineers computer and experimental equipment to allow students increasingly have become involved with projects in the life to become familiar with biomedical imaging hardware and and health sciences, biomedical engineering has emerged to software for biomedical image analysis. The laboratory bridge the gap between these sciences and engineering. has four lab benches with computers for teamwork, two desktop ultrasound machines, and two desktop magnetic The Roy J. Carver Department of Biomedical Engineering resonance imaging devices. In addition, the lab has 12 fosters interdisciplinary activities across departments and sets of in-house-built optics laboratory kits that use light colleges and maintains strong ties with the Carver College sources and semitranslucent objects to simulate basic x-ray of Medicine and the Colleges of Dentistry, Nursing, and physics. Students are introduced to concepts such as image Public Health. The department strives to provide a well- magnification as it relates to source-object distance (SOD)/ rounded and superior engineering education that attracts source-image distance (SID), depth-dependent magnification, outstanding students at both the undergraduate and graduate ideal point source verses parallel beam source effects, and levels; to conduct high-quality research that enables faculty projection image formation with lack of depth information members and students to keep pace with and initiate new artifacts. An instructor workstation and computer projector are developments; and to serve government, industry, and available for presentations and software demonstrations. The institutions worldwide by making the department's facilities lab is used primarily for the core course BME:2210 Bioimaging and faculty expertise accessible. and Bioinformatics, the elective course BME:5210 Medical Department faculty members have teaching and research Imaging Physics, and for senior design projects. expertise in areas related to cardiovascular and fluid Biomechanics and Biomaterials biomechanics, musculoskeletal biomechanics, biomaterials and tissue engineering, bioinstrumentation, biosystems, Laboratory biomedical imaging, biological signal analysis, bioinformatics The Biomechanics and Biomaterials Laboratory is equipped and computational biology, respiratory and pulmonary to perform experiments relating to the cardiovascular and engineering, and other allied fields. Several faculty members human musculoskeletal systems as well as the various have joint appointments with the Carver College of Medicine, properties of biomaterials. The laboratory houses a the College of Dentistry, or the College of Public Health. table-top material testing machine; two cone-and-plate Biomedical engineering undergraduates and graduate viscometers; compact stress-strain devices for characterizing students collaborate with faculty members and their cardiovascular tissues; goniometers; human structures colleagues on research problems in the life and health biomechanical modeling sets and associated sensors; digital sciences. still, video, and motion-capture cameras for kinematic analysis; a ski binding tester; a drop tower for impact testing; Programs digital calipers; various skeletal/bone models; an assortment of hand tools; and dissecting tools. The lab is used for the Undergraduate Program of Study course BME:2500 Biomaterials and Biomechanics, elective courses in cardiovascular and musculoskeletal biomechanics, Major and senior design projects. • Major in Biomedical Engineering (Bachelor of Science in Carver Biomechanics and Engineering) Mechanobiology Laboratory Graduate Programs of Study The Carver Biomechanics and Mechanobiology Laboratory (CBML) is a shared resource in the Roy J. Carver Department Majors of Biomedical Engineering with a mission to enhance teaching, • Master of Science in Biomedical Engineering training, and research in the field of biomechanics and mechanobiology. Biomechanics and mechanobiology involve • Doctor of Philosophy in Biomedical Engineering the study of how cells, fluids, tissues, and organs respond to physical forces. The lab contributes to the understanding of 2 Roy J. Carver Department of Biomedical Engineering cardiovascular disease, cancer metastasis, wound healing, Systems, Instrumentation, and Data medical device function, and stem cell therapies. Acquisition Laboratory The lab houses a planar biaxial stress-strain test apparatus, a pulse duplicator apparatus for characterizing blood flow The Systems, Instrumentation, and Data Acquisition through mechanical and tissue heart valves, a micron- Laboratory is equipped to measure biomedical variables resolution particle image velocimetry (micro-PIV) system for of clinical and physiological interest, to design and build quantifying flow and particle dynamics at the microscale, electronic instrumentation, and to conduct modeling a stent crimper for characterizing vascular stent designs, experiments in physiology. The lab is designed to give a multimode plate reader for quantifying cell activity and practice in designing and building electronic circuits to extracellular matrix (ECM) remodeling, a lyophilizer for measure, acquire, and analyze signals; and acquire and quantifying elastin and collagen content in soft tissue analyze images. It is used for the elective courses, BME:2200 samples, a micromanipulator for performing micropipette Systems, Instrumentation, and Data Acquisition and BME:4710 aspiration studies, and a controlled microscope room for Medical Device Design Studio, for biomeasurements and imaging live cells over long durations. The lab is used biological systems analysis, and senior design projects. for courses in cardiovascular biomechanics and cellular engineering, other elective courses, and senior design Research Facilities and projects. Laboratories Carver Cellular Engineering Laboratory Bioinformatics and Computational This laboratory trains students in cell culture and biochemical Biology Laboratory analysis techniques as a foundation for future work in quantitative cell-based studies. Students learn basic cell The Bioinformatics and Computational Biology Center is wired culture techniques, protein and nucleic acid analysis, as well for high-speed networking (100-megabit and gigabit ethernet, as techniques for studying the effects of engineered materials hardwired and wireless). It includes two dedicated Linux on cellular systems. clusters, 126 computing systems, 178 CPUs, more than 20 terabytes of RAM, and 250 terabytes of disk space. Computer Major equipment in the lab includes laminar flow hoods, resources include a dedicated experimental, reconfigurable cell culture incubators, centrifuges, spectrophotometers, an computer cluster of 18 Linux systems (36 CPUs) connected ultracold freezer, protein and nucleic acid electrophoresis with a dedicated, switched, copper Gigabit Ethernet intranet equipment, thermal cyclers, microscopes, an automated and a second dedicated computer server cluster of 16 microplate reader, and various support apparatus used in Linux systems (32 CPUs) connected with a dedicated, cell-based studies. This teaching lab is used for the courses, switched, fiber-optic Gigabit Ethernet intranet. An additional BME:2400 Cell Biology for Engineers and BME:5421 Cell 78 computers are used as compute servers, web servers, Material Interactions. database servers, file servers, workstations, laptops, and for Carver Medical Device Design other developmental and experimental needs. Laboratory Biomechanics of Soft Tissues The Carver Medical Device Design Laboratory provides a Laboratory space for students to gather to collaborate on the design The Biomechanics of Soft Tissues Laboratory (BioMOST) of medical implants, fixtures for testing such implants, and houses ViVitro Pulse duplicating left-heart simulating flow software for modeling, analyzing, and optimizing the function loop system, mechanical extension testers, durability of these devices. Space and equipment are provided for testers for accelerated testing of valves, flow loop with progressing from a back-of-the napkin sketch to a finalized programmable pump, resisters and compliance chambers, computer-aided design (CAD) model and through multiple optical micrometer, a furnace for nitinol shape memory alloy iterations of physical prototypes. stent fabrication, and the Vascular Simulations Replicator (a A variety of tools and equipment are available such as a micro portable realistic angio-suite friendly
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