Interdisciplinary Training in from nm to cm Coursework and discussion group options: 2017

MEMS Continuum BME Intermediate Finite Biomechanics Elements Orthopaedic How Plants Work Biomechanics Nonlinear Mechanics of Growth/Dev. Dev. Biology /Subcellular Biomechanics Interfaces / Attachments Mol/ Theoretical For Engineers

Mol/Cell Biology The Cell as a Mechanical length scale (nm to cm) to (nm scalelength Mechanical Chem/Phys of Biol Machine Soft Nanomaterials Macromolecular Interactions Biology Biophysics BME Physics ME Discipline (biology to mechanics)

Figure 1. Distribution of representative courses by discipline and length scale.


For trainees with and physics background, typically the basic “cross-disciplinary” course will be BME 5068 Molecular Cell Biology for Engineers and the second could be (for example) BIO 5357 and Physics of Biological Molecules. Core curriculum courses would include MEMS 5501 , BME 559 Intermediate Biomechanics, MEMS 5510 Finite Element Analysis.

For students with biology background, a basic cross disciplinary course could be BME 240 Biomechanics (or MEMS 253 Mechanics I, or Physics 411 Mechanics), and the second could be PHY 563 Biophysics or BME 559 Intermediate Biomechanics. In each case, if the trainee has taken such a cross-disciplinary course as an undergraduate, the course would not be required. For instance, many incoming biophysics students will have taken a mechanics course equivalent to Physics 411: Mechanics.

Many elective courses that cover aspects of mechanics in biology are available at WU, reflecting the large and diverse group of faculty with interests in this general area. A partial listing of course titles and brief descriptions is given below:

BME 240: Biomechanics - Principles of static equilibrium and applied to the human and a variety of biological problems (Shao, Taber)

BME 559: Intermediate Biomechanics - This course covers several of the fundamental theories of solid mechanics that are needed to solve problems in biomechanics. The theories of nonlinear elasticity, , and poroelasticity are applied to a large range of biological tissues including , articular , vessels, the heart, , and red blood cells (Shao)

BME 530A: Molecular cell biology for engineers - This course covers the biology of cells of higher : structure and ; cellular membranes and ; cell growth and oncogenic transformation; cellular transport, receptors and ; the cytoskeleton, the extracellular matrix, and cell movement (Sakiyama-Elbert)

BME 557: Cellular and Subcellular Biomechanics - An advanced biomechanics course intended to cover the applications of mechanics to biological problems at cellular and subcellular levels (Shao)

BME 562: Mechanics of Growth and Development - This course applies the fundamental principles of solid mechanics to problems involving growth, remodeling, and morphogenesis of cells, tissues and organs (Taber)

BME 563: Orthopaedic Biomechanics Bone - Basic and advanced solid mechanics applied to the musculoskeletal system, with a primary focus on bone and joint mechanics. Cross-listed as MEMS 5630 (Silva, Tang)

BME 564: Orthopaedic Biomechanics Cartilage/ - The biomechanics of orthopaedic soft tissues such as cartilage, tendon, ligament, meniscus. Cross-listed as MEMS 5640 (Thomopoulos, Lake)

BME 568: Cardiovascular Dynamics - This course focuses on the analysis of blood flow through the heart and blood vessels. It covers basic cardiovascular anatomy and , flow through heart chambers, valves, and coronary arteries, peristaltic flow in the embryonic heart, steady and unsteady flow in tubes, wave propagation in blood vessels, flow in collapsible tubes, and microcirculation (Taber)

BME 5908: The Cell as a Machine - The goals of this course are to provide a working understanding of the basic cell functions and the physical and chemical principles underlying them (EBICS consortium)

MEMS 5501: Continuum mechanics - A broad survey of the general principles governing the mechanics of continuous media (Pathak)

MEMS 5606: Soft Nanomaterials – This course intends to introduce the fundamental aspects of pertained to . Topics include responsive structures (films, capsules), nanocomposites, as nanomaterials and soft lithography. (Singamaneni)

MEMS 424: Introduction to Finite Element Methods in Structural Analysis – Application of finite element analysis (MEMS faculty)

MEMS 5510: Finite Element Analysis - Theory and application of the . (MEMS faculty)

MEMS 5560: Interfaces and Attachments in Natural and Engineered Structures - This course bridges the physiologic, surgical, and engineering approaches to connecting dissimilar materials. (Genin, Thomopoulos)

PHY 411: Mechanics – Motions of a particle and systems of particles; oscillations; gravitational and central forces. (Physics faculty)

PHY 509: Nonlinear Dynamics - The theoretical foundations of nonlinear dynamics, and its applications to phenomena in diverse fields including physics, biology, and chemistry. (Carlsson)

PHY 563: Topics in Theoretical Biophysics - Application of physical theory to a broad range of biological problems. (Carlsson)

BIO 5068: Fundamentals of Molecular Cell Biology - Research and experimental strategies to dissect molecular mechanisms that underlie cell structure and function, including protein (Cooper)

BIO 5357: Chemistry and Physics of Biological Molecules - This course covers three major types of biomolecular structure: , nucleic acids and membranes. Basic structural chemistry is presented, as well as biophysical techniques used to probe each type of structure. (Henzler-Wildman et al.)

BIO 5312: Macromolecular Interactions - This course will cover equilibria, kinetics and mechanisms of macromolecular interactions from a quantitative perspective. (Lohman et al.)

BIO 4071: - Analysis of a selected set of key processes in development, such as pattern formation, cell-cell signaling, morphogenesis. (Kornfeld, Taber)

Mechanobiology Journal Clubs and Discussion Groups Students are expected to participate in a journal club or discussion group outside their primary area of expertise (i.e., in the lab of a co-mentor or member of their thesis committee) for 1 semester during the period of support. Some relevant journal clubs at WU are listed below, with key lab participation noted in parentheses.

 Musculoskeletal Mechanobiology Journal Club (Tang, Thomopoulos, Silva, Genin)  Cytoskeleton Discussion Group (Carlsson, Cooper, Bayly, Dutcher, Dixit, Genin, Levin)  Biomechanics Journal Club (Taber, Bayly, Genin, Silva, Thomopoulos)  Plant Lunch (Dixit, Haswell)  Journal Club (Lohman, Galburt)  NMR Journal Club (Hall, Henzler-Wildman)  Development, Regeneration and Aging Journal Club (Solnica-Krezel, Taber)