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Autophagy Enhances Memory Erasure Through Synaptic Destabilization

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Autophagy Enhances Memory Erasure Through Synaptic Destabilization This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Behavioral/Cognitive Autophagy enhances memory erasure through synaptic destabilization Mohammad Shehata1,2, Kareem Abdou1,2, Kiriko Choko1,2, Mina Matsuo3, Hirofumi Nishizono2,3 and Kaoru Inokuchi1,2 1Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan 2Japan Science and Technology Agency, CREST, University of Toyama, 930-0194, Japan 3Division of Animal Experimental Laboratory, Life Science Research Center, University of Toyama, Toyama, 930-0194, Japan DOI: 10.1523/JNEUROSCI.3505-17.2018 Received: 10 December 2017 Revised: 14 February 2018 Accepted: 21 February 2018 Published: 19 March 2018 Author contributions: M.S. wrote the first draft of the paper; K.I. edited the paper. M.S., K.A., and K.I. designed research; M.S., K.A., and K.C. performed research; M.M., H.N., and K.I. contributed unpublished reagents/ analytic tools; M.S., K.A., K.C., and K.I. analyzed data; M.S. and K.I. wrote the paper. Conflict of Interest: The authors declare no competing financial interests. This work was supported by the Grant-in-Aid for Scientific Research on Innovative Areas “Memory dynamism” (JP25115002) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), JSPS KAKENHI grant number JP23220009, the Core Research for Evolutional Science and Technology (CREST) program (JPMJCR13W1) of the Japan Science and Technology Agency (JST), the Mitsubishi Foundation, the Uehara Memorial Foundation, and the Takeda Science Foundation support to K.I.; and by a Grant-in-Aid for young scientists from JSPS KAKENHI grant number JP25830007 to M.S. The Otsuka Toshimi Scholarship Foundation supported K.A. Corresponding authors: Kaoru Inokuchi, Ph.D., Professor, Department of Biochemistry, Faculty of Medicine, Graduate School of Medicine & Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan., E-mail: [email protected], Telephone: +81-76-434-7225; Fax: +81-76-434-5014, Mohammad Shehata, Ph.D., Visiting Associate, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. E-mail: [email protected] Cite as: J. Neurosci ; 10.1523/JNEUROSCI.3505-17.2018 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. 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