Kanazawa Medical University Research Activities and Publications
VOL.27 2015
Kanazawa Medical University I N D E X
Code Depaertment Page Code Depaertment Page
Basic Medical Science 0100 Department of Anatomy Ⅰ ・・・・・・1 0460 Department of Pediatric Surgery ・・・・・・70 0110 Department of Anatomy Ⅱ ・・・・・・2 0470 Department of Ophthalmology ・・・・・・72 0120 Department of Physiology Ⅰ ・・・・・・3 0475 Department of Otorhinolaryngology ・・・・・・76 0130 Department of Physiology Ⅱ ・・・・・・5 0485 Department of Head and Neck Surgery ・・・・・・78 0140 Department of Biochemistry Ⅰ ・・・・・・7 0490 Department of Dermatology ・・・・・・79 0150 Department of Biochemistry Ⅱ ・・・・・・8 0500 Department of Urology ・・・・・・81 0160 Department of Pharmacology ・・・・・・9 0510 Department of Obstetrics and Gynecology ・・・・・・83 0170 Department of Pathology Ⅰ ・・・・・・11 0520 Department of Anesthesiology and 0180 Department of Pathology Ⅱ ・・・・・・13 Perioperative Medicine ・・・・・・85 0190 Department of Microbiology ・・・・・・15 0540 Department of Physical and Rehabilitation 0200 Department of Immunology ・・・・・・16 Medicine ・・・・・・87 0210 Department of Medical Zoology ・・・・・・17 0550 Department of Emergency Medicine ・・・・・・88 0220 Department of Pathology and Laboratory 0570 Department of Community Medicine ・・・・・・89 edicine ・・・・・・18 0575 Department of Gastroenterological Endoscopy ・・・・・・90 0230 Department of Social and Environmental 0580 Department of Oral and Maxillofacial Surgery ・・・・・・92 Medicine ・・・・・・20 0240 Department of Epidemiology and Public Heaｌｔｈ ・・・・・・21 University Hospital 0250 Department of Legal Medicine ・・・・・・24 0635 Hepatology ・・・・・・93 0260 Department of Medical Education ・・・・・・25 0675 Health Evaluation Center ・・・・・・95
Clinical Medicine Medical Research Institute 0300 Department of Cardiology ・・・・・・26 7100 Department of Life Science ・・・・・・98 0310 Department of Respiratory Medicine ・・・・・・28 7200 Department of Advanced Medicine ・・・・・・102 0320 Department of Gastroenterology ・・・・・・30 7310 Division of Innovative Research ・・・・・・106 0330 Department of Nephrology ・・・・・・32 7320 Division of Vision Research for Environmental 0340 Department of Diabetology and Endocrinology ・・・・・・35 Health ・・・・・・108 0350 Department of Hematology and Immunology ・・・・・・38 7340 Division of Anticipatory Molecular Food Science 0360 Department of Neurology ・・・・・・41 and echnology ・・・・・・112 0363 Department of Medical Oncology ・・・・・・44 7350 Division of Systems Bioscience for Drug 0366 Department of Infectious Diseases ・・・・・・46 Discovery Based on Intrinsically Disordered 0368 Department of General Internal Medicine ・・・・・・47 Proteins ・・・・・・113 0370 Department of Geriatric Medicine ・・・・・・49 7400 Research Support Cente ・・・・・・115 0380 Department of Pediatrics ・・・・・・50 0390 Department of Neuropsychiatry ・・・・・・52 School of Nursing 0400 Department of Radiology ・・・・・・54 8010 Fundamental Nursing ・・・・・・118 0410 Department of Cardiovascular Surgery ・・・・・・56 8040 Adult Nursing ・・・・・・120 0415 Department of Thoracic Surgery ・・・・・・57 8050 Gerontological Nursing ・・・・・・121 0420 Department of General and Digestive Surgery ・・・・・・59 8060 Pediatric Nursing ・・・・・・122 0430 Department of Orthopedics Surgery ・・・・・・62 8070 Maternity Nursing・Midwifery ・・・・・・123 0440 Department of Neurosurgery ・・・・・・65 8080 Public Health Nursing ・・・・・・124 0450 Department of Plastic and Reconstructive 8085 Psychiatric and Mental Health Nursing ・・・・・・125 Surgery ・・・・・・68 8090 Home Care Nursing ・・・・・・126 8100 Medical Science ・・・・・・127 Code Depaertment Page Code Depaertment Page
Department of General Education 8610 Natural Science ・・・・・・129 8620 Human Science ・・・・・・131
Affiliated Institution 9030 Northern Noto Institute of Community Medicine ・・・・・・133 9050 FDD-MB Center ・・・・・・134
Himi Municipal Hospital 9100 Himi Municipal Hospital ・・・・・・135 Basic Medical Science 0100 Department of Anatomy Ⅰ
Faculty
Title Name Field of Specialization Professor HATTA Toshihisa developmental biology, neuroscience Professor HIGASHI Nobuaki macroscopic anatomy, embryology Senior Assistant Professor SHIMADA Hiroki Medical science of free radical
Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant, apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry, human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide, scavenger, VDAC, anomaly of muscles and blood vessels
Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine network. 2. Cytochemical study of the cytotoxicity by reactive oxygen species. 3. Biological functions of VDAC family proteins. 4. Macroscopic studies on the variations of muscles and blodd vessels. 5. Comparative anatomical studies on the brain evolution
Publications
Originals 0100B001 (N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki:Three-dimensional structure of seminiferous tubules in the adult mouse, Journal of Anatomy, 227:5;686-694, 2015.
0100B002 E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.
0100B003 T.Tsukada, E.Simamura, H.Shimada, T.Arai, N.Higashi, T.Akai T, H.Iizuka, T.Hatta:The suppression of maternal- fetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in
mice, PLoS One, 10:6;e0129011, 2015.
1 0110 Department of Anatomy Ⅱ
Faculty
Title Name Field of Specialization Professor HONMA Satoru gross anatomy Neuroanatomy, immunohistochemistry, electron microscopy, 3D Senior Assistant Professor SONOMURA Takahiro reconstruction immunocytochemistry, pituitary, cell proliferation, electron Senior Assistant Professor KOMINAMI Rieko microscopy Senior Assistant Professor YASUTAKA Satoru gross anatomy, central nervous system
Keywords of Research
arthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH, GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA, Neuroanatomy, FIB/SEM, BMI, gustatory,
Outline of Research
Theme of researches 1)Human gross anatomy 2)Neural network of the basal ganglia 3）Circuit of gustatory in the central nervous system 4）Anatomical study of brain white matter by using fiber dissection technique 5）Immuno-histochemical study of pituitary gland
Publications
Originals 0110B001 (N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki:Three-dimensional structure of seminiferous
tubules in the adult mouse, Journal of Anatomy, 227:5;686-694, 2015.
0110B002 (T.Tsukahara), M.Masuhara, H.Iwai, T.Sonomura, T.Sato:Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female
mice, Biochemical and Biophysical Research Communications, 465:1;145-151, 2015.
0110B003 (H.Iwai), E.Kuramoto, A.Yamanaka, T.Sonomura, M.Uemura, T.Goto:Ascending parabrachio-thalamo-striatal
pathways: Potential circuits for integration of gustatory and oral motor functions., Neuroscience, 294:1-13, 2015.
2 0120 Department of Physiology Ⅰ
Faculty
Title Name Field of Specialization Professor KATO Nobuo Brain Science Senior Assistant Professor TAJIMA Nobuyoshi molecular physiology Assistant Professor UCHIUMI Osamu Neuroscience
Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, field potential, propagating signal, horizontal propagation, oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording, intracellular staining, Neuroethology, Behavioral test battery, BK channel
Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not a mere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellular messenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability.
Publications
Originals 0120B001 Y.Zhang, F.Wang, X.Luo, L.Wang, P.Sun, M.Wang, Y.Jiang, J.Zou, O.Uchiumi, R.Yamamoto, T.Sugai, K.Yamamoto, N.Kato:Cognitive improvement by photic stimulation in a mouse model of Alzheimer's disease,
Current Alzheimer Research, 12:9;860-869, 2015.
0120B002 P.Sun, Q.Zhang, Y.Zhang, F.Wang, L.Wang, R.Yamamoto, T.Sugai, N.Kato:Fear conditioning suppresses large- conductance calcium-activated potassium channels in lateral amygdala neurons., Physiology & Behavior, 138:279-
284, 2015.
0120B003 L.Wang, H.Kang, Y.Li, Y.Shui, R.Yamamoto, T.Sugai, N.Kato:Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease,
Neuropharmacology, 92:8-15, 2015.
0120B004 T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio:Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes
to heat sensitivity., British Journal of Pharmacology, 172:4;1020-1033, 2015.
0120B005 Y.Shui, L.Wang, X.Luo, O.Uchiumi, R.Yamamoto, T.Sugai, N.Kato:Homer1a disruption increases vulnerability to
predictable subtle stress normally sub-threshold for behavioral changes, Brain Research., 1605:70-75, 2015.
0120B006 Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.
0120B007 P Sun, Q Zhang, Y Zhang, F Wang, R Chen, R Yamamoto, N Kato:Homer1a-dependent recovery from depression-
like behavior by photic stimulation in mice, Physiology & Behavior, 147:334-341, 2015.
3 0120B008 F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.
0120B009 Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.
Presentations at Conference
International Conference (Synposium) 0120H001 K.Tanaka, Yongzhi Li, N.Kato:Memory disturbance in mice treated with intraventricular administration of CSF
from NMDAR-encephalitis patients, The Lancet Neurology Autoimmune Disorders Conference, Balcerona, 2015.
International Conference (Presentations) 0120I001 N.Kato:Behavioral recovery by transcranial magnetic stimulation in a mouse model of depression is dependent on
Homer1a expression., 1st International Brain Stimulation Conference, Singapore, 2015.
0120I002 N.Kato,J.Zou:Deficits in Morris water maze performance exacerbated by minimal neocortical injury in a mouse
model of Alzheimer's disease, Neuroscience 2015, Chicago, 2015.
4 0130 Department of Physiology Ⅱ
Faculty
Title Name Field of Specialization SHIBAMOTO Professor Circulatory Physiology Toshishige Professor KURATA Yasutaka Cardiac Electrophysiology Senior Assistant Professor TANIDA Mamoru Circulatory Physiology Senior Assistant Professor WAN Mofei Circulatory Physiology Assistant Professor KUDA Yuichi Circulatory Physiology
Keywords of Research
physiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemaker mechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics, computer simulation, smooth muscle, vascular electrophysiology, arthery, vein
Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms of regulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity and arrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects of vasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect of NO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, and the possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.
Publications
Originals 0130B001 M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.Toga:Pulmonary vascular and airway responses to systemic vasoconstrictors in anesthetized BALB/c mice. , Journal of cardiovascular
pharmacology, 65:4;325-334, 2015.
0130B002 (Y.Konishi), Y.Koosaka, R.Maruyama, K.Imanishi, K.Kasahara, A.Matsuda, S.Akiduki, Y.Hishida, Y.Kurata, T.Shibamoto, J.Satomi, M.Tanida:l-Ornithine intake affects sympathetic nerve outflows and reduces body weight
and food intake in rats. , Brain Research Bulletin, 111:48-52, 2015.
0130B003 (R.Endo), Y.Kurata, T.Notsu, P.Li, K.Morikawa, T.Kondo, K.Ogura, J.Miake, A.Yoshida, Y.Shirayoshi, H.Ninomiya, K.Higaki, M.Kuwabara, K.Yamamoto, Y Inagaki, I.Hisatome:Stabilization of Kv1.5 channel protein by
the inotropic agent olprinone., European Journal of Pharmacology, 765:488-494, 2015.
0130B004 (N.Maharani), YK.Ting, J.Cheng, A.Hasegawa, Y.Kurata, P.Li, Y.Nakayama, H.Ninomiya, N.Ikeda, K.Morikawa, K.Yamamoto, N.Makita, T.Yamashita, Y.Shirayoshi, I.Hisatome:Molecular mechanisms underlying urate-induced
enhancement of Kv1.5 channel expression in HL-1 atrial myocytes., Circulation Journal, 79:12;2659-2668, 2015.
5 0130B005 M.Tanida, N.Yamamoto, DA.Morgan, Y.Kurata, T.Shibamoto, K.Rahmouni:Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated
protein kinase., The Journal of Neuroscience, 35:2;474-484, 2015.
0130B006 M.Tanida, H.Gotoh, N.Yamamoto, M.Wang, Y.Kuda, Y.Kurata, M.Mori, T.Shibamoto:Hypothalamic nesfatin-1 stimulates sympathetic nerve activity via hypothalamic ERK signaling. , Diabetes, 64:11;3725-3736, 2015
0130B007 T.Shibamoto, Y.Kuda, M.Tanida, M.Wang, Y.Kurata:Exercise attenuates ischemia-reperfusion injury of nonalcoholic fatty liver of OLETF rat., Journal of Gastroenterology, Pancreatology & Liver Disorders, 2:2;1-6,
2015.
0130B008 (P.Li), Y.Kurata, N.Maharani, E.Mahati, K.Higaki, A.Hasegawa, Y.Shirayoshi, A.Yoshida, T.Kondo, Y.Kurozawa, K.Yamamoto, H.Ninomiya, I.Hisatome:E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in
mammalian cells., Journal Molecular and Cellular Cardiology, 86:138-146, 2015.
0130B009 T.Shibamoto, M.Wang:The effect of tolvaptan, a vasopressin V2 receptor antagonist, on the portal venous
pressure in rats., Japanese Pharmacology & Therapeutics, 43:9;1283-1294, 2015.
0130B010 (S.Yagi), M.Tanida, J.Satomi:Possible role of afferent autonomic signals in abdominal organs in anorexic and
cardiovascular responses to nicotine injection in rats., NeuroReport, 26:8;445-449, 2015.
0130B011 (Y.Shibasaki), A.Hayata-Takano, K.Hazama, T.Nakazawa, N.Shintani, A.Kasai, K.Nagayasu, R.Hashimoto, M.Tanida, T.Katayama, S.Matsuzaki, K.Yamada, M.Taniike, Y.Onaka, Y.Ago, JA.Waschek, K.Köves, D.Reglödi, A.Tamas, T.Matsuda, A.Baba, H.Hashimoto:Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide.,
Neuroscience, 297:95-104, 2015.
0130B012 M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, Y.Kurata:Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized rats., Experimental Lung Research,
41:6;324-334, 2015.
Others 0130F001 N.Okumura, M.Tanida, A.Niijima, N.Tsuruoka, Y.Kiso, Y.Horii, K.Nagai:Carnosine and the control of blood
glucose, Food and Nutritional Components in Focus, 8:257-276, 2015.
Presentations at Conference
International Conference (Presentations) 0130I001 S.Shinomiya, M.Nojiri, K.Nakase, R.Kato, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa, S.Mizuno, K.Osanai, T.Shibamoto, H.Toga:Nitric oxide and β2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice, Pulmonary vascular research
institute, China, 2015.
6 0140 Department of Biochemistry Ⅰ
Faculty
Title Name Field of Specialization Professor IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins Assistant Professor SAKASAI Ryo DNA damage response induced by anti-cancer drugs Assistant Professor SUNATANI Yumi Function of DNA damage repair protein Assistant Professor MATSUI Tadashi Molecular biology, DNA repair, p53-binding proteins
Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction
Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2, that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 in cellular responses to DNA DSBs.
Publications
Originals 0140B001 Y.Matsui, Y.Sunatani, N.Hayashi, K.Okino, Y.Okushi, K.Mukai, H.Adachi, H.Yamaya, K.Iwabuchi, H.Yokoyama:DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts, Clinical and
Experimental Nephrology, 20:3;479-488, 2015.
Reviews 0140C001 R.Sakasai, K.Iwabuchi:The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase Ⅰ
poison in conjunction with DNA replication and RNA transcription, Genes & genetic systems, 90:4;187-194, 2015.
Presentations at Conference
International Conference (Presentations) 0140I001 Y.Sunatani, M.K.Sharma, R.P.Kamdar, T.Matsui, R.Sakasai, M.Hashimoto, Y.Matsumoto, K.Iwabuchi:Phosphorylation-mediated Regulation of Apoptosis By NHEJ-protein XRCC4, 15th International
Congress of Radiation Research, Kyoto, 2015.
0140I002 R.Sakasai, Y.Sunatani, T.Matsui, M.Hashimoto, K.Iwabuchi:Ubiquitin-dependent Activation of DNA-PKcs Leads to Chromosomal Aberration in Response to One-ended DNA Double Strand Breaks, 15th International Congress of
Radiation Research, Kyoto, 2015.
0140I003 Y.Matsui, Y.Sunatani, K.Iwabuchi, H.Yokoyama:DNA double strand breaks accelerated collagen type VI secretion
of glomerular endothelial cells, ERA-EDTA Congress in Amsterdam The Netherlands, London, 2015.
7 0150 Department of Biochemistry Ⅱ
Faculty
Title Name Field of Specialization Professor YONEKURA Hideto Molecular mechanisms of angiogenesis, Alternative mRNA processing MicroRNA involved in angiogenesis, Functions of FGF-2 binding Associate Professor YOSHITAKE Yoshino protein Senior Assistant Professor IKEDA Takayuki Molecular mechanisms of angiogenesis, Alternative mRNA processing Assistant Professor YOSHITOMI Yasuo Molecular mechanisms of angiogenesis and vasculogenesis
Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor, cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications, endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing, centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen receptor,
Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing 2. Cellular and molecular mechanisms in angiogenesis 3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction 4. Molecular mechanisms in development of diabetic vascular complications
Publications
Originals 0150B001 E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.
0150B002 S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75, 2015
Presentations at Conference
International Conference (Presentations) 0150I001 H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.
8 0160 Department of Pharmacology
Faculty
Title Name Field of Specialization Electrophysiological and pharmacological study of excitable and non- Professor NISHIO Matomo excitable cells, Pharmocology of cardiovascular drugs Kinetics of NO(nitric oxide)-related compounds in cardiovascular Professor(Additional Post) ISHIBASHI Takaharu system Electrophysiology and behavioural pharmacology in central and Senior Assistant Professor MASUOKA Takayoshi periphenal nervous system Senior Assistant Professor YOSHIDA Junko Pharmacology in cardiovascular system, Cancer chemotherapy Pharmacology of cardiovascular drugs, Kinetics of NO-related Assistant Professor IMAIZUMI Noriko compounds in cardiovascular systems, Cancer chemotherapy
Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation, cell biology, hippocampal synapses, muscarinic acetylcholine receptorrvous system, peripheral sensory neuron, autonomic neuron, central ne, metabotropic glutamate receptor, receptorology,
Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells ２ Signaling mechanisms of bioactive substances ３ Electropharmacology of the drugs acting on the cardiovascular system ４ Pharmacological study of the ischemic cardiomyocytes ５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system ６ Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation
Publications
Originals 0160B001 T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio:Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes
to heat sensitivity., British Journal of Pharmacology, 172:4;1020-1033, 2015.
Reviews 0160C001 T.Masuoka, T.Ishibashi, M.Nishio:Biphasic modulation of noxious heat sensitivity in sensory neurons by peripheral
metabotropic glutamate receptors, Inflammation and Cell Signaling, 2:602, 2015.
0160C002 J.Yoshida, T.Ishibashi, T.Masuoka, N.Imaizumi, M.Nishio:Ca2+ Signalimg molecules STIM1/Orail and Cancer,
Journal of Kanazawa Medical University, 40:2・3;69-77, 2015.
9 Presentations at Conference
International Conference (Presentations) 0160I001 (J. Gallar),T.Masuoka,C.Belmonte:Effects of amitriptyline on the spontaneous and stimulus-evoked activity of corneal cold-sensitive nerve terminals, Association for Ocular Pharmacology and Therapeutics 2015, Charleston,
2015.
0160I002 T.Masuoka, J.Gallar, C.Belmonte:Effects of sodium channel blocker amitriptyline on the spontaneous and stimulus- evoked activity of corneal cold-sensitive nerve terminals in intact and tear-deficit guinea-pig eye, The association
for Research in vision and Ophtalmology 2015, Denver, 2015.
10 0170 Department of PathologyⅠ
Faculty
Title Name Field of Specialization Professor KIYOKAWA Etsuko Experimental Pathology, Fluorescent Imaging Assistant Professor TAKEDA Haruna Mouse model for carcinogenesis、Two-photon microscopy imaging Assistant Professor AIKAWA Akane Basic medical science
Keywords of Research
in vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin, epithelial regeneration,
Outline of Research
We observed signal transduction pathways in mice and cells expressing FRET biosensors, to understand cancer development and invasion/metastasis, and epithelial regeneration.. We also develop the system to manipulate cell signaling to understand the molecular mechanisms for morphology Focusing on the lens epithelial cells, we are now investigating roles of DOCK5, an activator for Rac1, in the epithelial morphology and maintenance.
Publications
Originals 0170B001 (Y.Kumagai), H.Naoki, E.Nakasho, Y.Kamioka, E.Kiyokawa, M.Matsuda:Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice, Oncogene.,
34:8;1051-1057, 2015.
0170B002 H.Takeda, Z.Wei, H.Koso, A.G.Rust, C.C.K.Yew, M.B.Mann, J.M.Ward, D.J.Adams, N.G.Copeland, N.A.Jenkins:Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor
progression, Nature genetics, 47:142-150, 2015.
0170B003 H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa:Regulation of Ripply1 expression in MDCK organoids,
Biochemical and Biophysical Research Communications, 468:1-2;337-342, 2015.
Presentations at Conference
International Conference (Key Note Lecture)
0170G001 E.Kiyokawa:FRET imaging in organoids and mice., 2015 CRI Cancer Symposium, Hwasun Kumho, 2015.
0170G002 E.Kiyokawa:FRET imaging in organoids and mice, 2015 Biophysical Society Thematic Meeting in Taiwan New
Biological Frontiers Illuminated by Molecular Sensors and Actuators, Taipei, 2015.
0170G003 E.Kiyokawa:FRET imaging in organoids and mice., The International Chemical Congress of Pacific Basin Societies
2015, Honolulu, 2015.
11
International Conference (Presentations) 0170I001 H.Takeda, H.Yoshizaki, E.Kiyokawa:In vivo imaging using a two-photon microscope in the mouse intestine, International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular
Activities, Kyoto, 2015.
0170I002 T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:FGF-2 regression of the tropomyosin expression through MAPK/ERK kinase pathway in lens epithelial cells, Association for Research in Vision and
Ophthalology, Denver, 2015.
0170I003 E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expression profiling of lens epithelial cells in a rat posterior capsular opacity model in vivo, Association for Research in Vision and
Ophthalology, Denver, 2015.
0170I004 A.Aikawa, E.Kiyokawa:In vivo fluorescent imaging of colon cancer metastasis, The Second International Meeting
for Epithelial Tubulology, Sapporo, 2015.
0170I005 X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.
0170I006 E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expressin profiling of lens epithelial cells in posterior capsular opacity and the role of decorin, The 3rd International Conference on the Lens
2015, Kona, 2015.
0170I007 T.Shibata, S.Shibata, H.Sasaki, DP.Singh, E.Kiyokawa, M.Ikawa, E.Kubo:Suppression of injury-induced epithelial- mesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9, The 3rd International
Conference on the Lens 2015, Kona, 2015.
12 0180 Department of PathologyⅡ
Faculty
Title Name Field of Specialization Professor UEDA Yoshimichi Bone and soft tissue tumor, Pulmonary pathology Associate Professor SATO Katsuaki Diagnostic pathology of tumor Assistant Professor SHIMASAKI Miyako molecular pathology of the lung cancer
Keywords of Research
atherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB,
Outline of Research
1. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelial- mesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene network/pathway analysis. 2. Molecular pathological diagnosis by FISH using probes origination from BAC clones and RT-PCR methods. 3. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM degradation and matrix metalloproteinases.
Publications
Originals 0180B001 L.Tang, Y.Sakai, Y.Ueda, S.Katsuda:Effects of oral administration of tripeptides derived from type I collagen (collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits, Journal of Bioscience and
Bioengineering, 119:5;558-563, 2015.
0180B002 S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015.
0180B003 K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda, M.Sagawa:Diffusion weighted imaging can distinguish benign from malignant mediastinal tumors and mass lesions:
comparison with positron emission tomography, Asian Pacific Journal of Cancer Prevention, 16:6469-6475, 2015.
0180B004 K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda, M.Sagawa:Diagnostic performance of diffusion-weighted imaging for multiple hilar and mediastinal lymph nodes with
FDG accumulation, Asian Pacific Journal of Cancer Prevention, 16:6401-6406, 2015.
0180B005 T.Ichiseki, S.Ueda, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto:Age-related changes of mitochondrial transcription factor a expression in rotator cuff degeneration, American Journal of Translational Research, 7:10;2099-2104, 2015.
13
Case Reports 0180D001 I.Chikazawa, S.Inoue, Y.Nakazawa, D.Nakai, H.Tachibana, K.Suga, N.Morita, T.Tanaka, K.Miyazawa, K.Sato:A
case of mucinous tubular and spindle cell carcinoma, Japanese journal of urological surgery, 28:1;99-102, 2015.
14 0190 Department of Microbiology
Faculty
Title Name Field of Specialization Associate Professor HIMEDA Toshiki Neurovirology
Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis,
Outline of Research
Studies on pathomechanism of virus induced demyelination
15 0200 Department of Immunology
Faculty
Title Name Field of Specialization Professor NAKAMURA Akira Immunology Professor(Additional Post) KOHNO Hiroyuki Experimental Pathology, Tumor immunology Assistant Professor TAKEDA Kazuya Immunology, Neuropathology Assistant Professor MATSUBA Shintaro Immunological pharmacology Assistant Professor YABE-WADA Toshiki Immunology, Functional biochemistry, Structural biochemistry
Keywords of Research
allergy, autoimmune disease, immunoglobulin-like receptor,
Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors (FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationship between immunoreceptors and diseases by using animal models for human diseases.
16 0210 Department of Medical Zoology
Faculty
Title Name Field of Specialization Senior Assistant Professor OIKAWA Yosaburo diagnosis of parasitic disease, tick-borne disease Senior Assistant Professor MURAKAMI Manabu Infection-mediated arthropod
Keywords of Research
parasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia musculi, Leptotrombidium, Japanese encephalitis Virus, mosquito, Culex tritaeniorhynchus, Culex tritaeniorhynchus, Aedes albopictus
Outline of Research
The main subjects of our department are as follows: 1.Development of immunological and molecular biological diagnosis of parasitic diseases. 2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect. 3.Investigation of mosquito situation around the pigpen in Ishikawa prefecture, and JE virus distribution.
Books
0210A001 T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.
Publications
Originals 0210B001 Y.Oikawa:Control of proliferation of Acanthamoeba in a soft contact lens case demonstrated by a newly devised
culture method using a liquid medium, Journal of Kanazawa Medical University, 40:1;1-8, 2015.
Reviews 0210C001 Y.Oikawa, M.Murakami:Investigation and research relevant to some sanitary animals examined in our department,
Journal of Kanazawa Medical University, 40:2・3;64-68, 2015.
17 0220 Department of Pathology and Laboratory Medicine
Faculty
Title Name Field of Specialization surgical pathology, molecular pathology, basic science on bone and Professor NOJIMA Takayuki soft tissue tumors Surgical pathology, Pathological study of head and neck, lung, Professor MINATO Hiroshi mediastinum, and pleura Senior Assistant Professor KUROSE Nozomu surgical pathology, molecular pathology Assistant Professor KOBAYASHI Eriko surgical pathology, molecular pathology Assistant Professor NAKADA Satoko surgical pathology Assistant Professor SHIOYA Akihiro Surgical pathology
Keywords of Research
pathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood gas analysis, pulmonary function test, pulmonary pathology, lung, mediastinum, and pleura, head and neck, salivary gland
Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL) during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosis of this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for these equipments with newly developed standard materials for blood gas analysis.
Books
0220A001 T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.
Publications
Originals 0220B001 T.Satoh-Nakamura, N.Kurose, T.Kawanami, T.Nakamura, H.Iwao-Kawanami, A.Nakajima, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki:CD14+ follicular dendritic cells in lymphoid follicles may play a role in
the pathogenesis of IgG4-related disease, Biomedical Research, 36:2;143-153, 2015.
0220B002 S.Nakada, H.Minato, T.Terauchi, Y.Miwa, N.Kurose, M.Nakano, T.Nojima:Prevalence of liquid based cytology in the Hokuriku district based on a questionnaire survey, The Journal of the Japanese Society of Clinical Cytology,
54:2;128-134, 2015.
0220B003 H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa:Regulation of Ripply1 expression in MDCK organoids,
Biochemical and Biophysical Research Communications, 468:1-2;337-342, 2015.
18
Reviews 0220C001 Y.Ohno, M.Noguchi, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka, N.Kurose, H.Minato:Tangential frozen section analysis for the surgical margins in breast-conserving surgery, American Journal of Breast Cancer Research , 2:1;9-20, 2015.
Case Reports 0220D001 H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai, T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.
0220D002 S.Nakada, H.Minato, T.Takegami, N.Kurose, H.Ikeda, M.Kobayashi, Y.Sasagawa, T.Akai, T.Kato, N.Yamamoto, T.Nojima:NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma
with late distant metastases, Brain Tumor Pathology, 32:4;268-274, 2015.
0220D003 N.Ueda, T.Ohnishi, D.Kaida, H.Fujita, S.Kinami, T.Kosaka, E.Kinoshita, N.Kurose:A case of primary liver
adenosquamous carcinoma with central necrosis, 29:5;905-912, 2015.
0220D004 R.Kato, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, H.Minato:A case of NUT midline carcinoma of the lung, Japanese
Journal of Lung Cancer, 55:7;1080-1085, 2015.
Presentations at Conference
International Conference (Presentations) 0220I001 M.Doai, I.Toyota, H.Tonami, Y.Sasagawa, O.Tachibana, T.Nojima:Utility of apparent diffusion coefficient value for distinguishing pituitary atypical adenomas from typical adenomas, European Congress of Radiology2015, Wien,
2015.
0220I002 Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th Annual Asian Oncology Summit, 12th Annual Conference of the OOTR and the Kyoto Breast Cancer Consensus
Conference 2016, 2015.
0220I003 H.Minato, A.Iwakoshi, M.Hasegawa, S.Ichihara, S.Moritani, T.Tsuzuki, Y.Yatabe:A tracheal tumor of a young girl,
The 6th Korean-Japanese Conjoint Slide Conference of Pulmonary Pathology, Seoul, 2015.
19 0230 Department of Social and Environmental Medicine
Faculty
Title Name Field of Specialization Professor(Additional Post) HONDA Ryumon Environmental health, Statistical analysis, Analytical chemistry Associate Professor ISHIZAKI Masao Occupational Health, Job stress
Keywords of Research
occupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work, work time
Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies for health promotion
Publications
Originals 0230B001 Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.
0230B002 M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using a mixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.
Presentations at Conference
International Conference (Presentations) 0230I001 SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.
0230I002 Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse: Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd International Symposium on Shiftwork and Working Time, Elsinore, 2015.
0230I003 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
20 0240 Department of Epidemiology and Public Health
Faculty
Title Name Field of Specialization Professor NISHINO Yoshikazu Epidemiology of cancer, preventive medicine Professor(Additional Post) MORIKAWA Yuko Cardiovascular epidemiology, occupational medicine Associate Professor SAKURAI Masaru Cardiovascular epidemiology, preventive cardiology Environmental epidemiology, Environmental health sciences, Associate Professor NISHIJO Muneko Epidemiology of cadmium pollution Assistant NAGASAWA Shinya Cardiovascular epidemiology, preventive cardiology Professor(Additional Post)
Keywords of Research
epidemiology, public health, cancer, hypertension, diabetes mellitus, screening, shift work, nutrition, calcium, stress, smoking, insulin resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease, cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide, community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin
Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases Environmental Epidemiology Epidemiology of Occupation-related Diseases Epidemiology of Congenital Anomalies Epidemiology of Interactable Diseases Clinical Epidemiology
Publications
Originals 0240B001 K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.
0240B002 PT.Tai, M.Nishijo, NTN.Anh, TN.Nghi, HV.Luong, TH.Anh, VT.Nguyen, H.Nishijo:Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at 1 year of age, Science of the Total Environment, 536:575-581,
2015.
0240B003 (A.Takazakura), M.Sakurai, Y.Bando, H.Misu, Y.Takeshita, Y.Kita, A.Shimizu, T.Hayakawa, K.Kato, S.Kaneko, T.Takamura:Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic
nephropathy, Journal of Diabetes Investigation, 6:3;346-353, 2015.
0240B004 SY.Nagasawa, T.Ohkubo, K.Masaki, E.Barinas-Mitchell, K.Miura, T.Seto, A.El-Saed, T.Kadowaki, BJ.Willcox, D.Edmundowicz, A.Kadota, RW.Evans, S.Kadowaki, A.Fujiyoshi, T.Hisamatsu, MH.Bertolet, T.Okamura, Y.Nakamura, LH.Kuller, H.Ueshima, A.Sekikawa; ERA-JUNP Study Group:Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white,Japanese-American and Japanese men: The ERA-
JUMP study, Journal of Atherosclerosis Thrombosis, 22:6;590-598, 2015.
21 0240B005 M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido, H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.
0240B006 (K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice for
renal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.
0240B007 N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis and
Thrombosis, 22:10;1051-1060, 2015.
0240B008 (M.Satoh), T.Ohkubo, K.Asayama, Y.Murakami, M.Sakurai, H.Nakagawa, H.Iso, A.Okayama, K.Miura, Y.Imai, H.Ueshima, T.Okamura; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH- JAPAN) Research Group:Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: Evidence for cardiovascular prevention from observational cohorts in Japan.,
Hypertension, 65:3;517-524, 2015.
0240B009 (T.Hisamatsu), K.Miura, A.Fujiyoshi, T.Okamura, T.Ohkubo, SY.Nagasawa, M.Horie, A.Okayama, H.Ueshima; NIPPON DATA80 Research Group:Long-term outcomes associated with prolonged PR interval in the general
Japanese population, International Journal of Cardiology, 184:291-293, 2015.
0240B010 (HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo, H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.
0240B011 TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa, T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.
0240B012 M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using a mixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.
0240B013 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.
0240B014 (IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination for
survival data, Biometrical Journal, 57:4;592-613, 2015.
0240B015 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause mortality increased by environmental cadmium exposure in the Japanese general population in cadmium non-
polluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.
Reviews 0240C001 (C.Chen),P.Xun, M.Nishijo, A.Sekikawa, K.He:Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case-control studies among individuals without occupational exposure history,
Environmental Science and Pollution Research, 22:22;17465-17474, 2015.
0240C002 (K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.
22 Presentations at Conference
International Conference (Synposium) 0240H001 M.Nishijo:History of Cd pollution and health effect., A Symposium on Health Effects among Cadmium Exposed
Inhabitants in Mae Sot District,Tak Province,Thailand, Mae Sot Thailand, 2015.
0240H002 M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in the Cadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.
International Conference (Presentations) 0240I001 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
0240I002 SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.
0240I003 Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd
International Symposium on Shiftwork and Working Time, Elsinore, 2015.
0240I004 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
0240I005 (TT.Pham),M.Nishijo,MT.Do,NT.Pham,VL.Hoang,HA.Tran,VL.Nguyen,NN.Tran,VK.Tran,TT.Dang,TL.Nguyen,H. Nishijo,H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium on Halogenated
Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.
0240I006 TN.Nghi, PT.Tai, PN.Thao, M.Nishijo:Dioxin concentration in breast milk and umbilical cord blood samples of mother-baby pairs living near Bien Hoa Airport., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vientnam, Hanoi, 2015.
0240I007 M.Nishijo, TN.Nghi, PN.Thao, PT.Tai, AH.Tran, HV.Luong, H.Nishijo:Dioxin effects on groeth and neurodevelopment of infants and children in Vietnam., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vietnam, Hanoi, 2015.
23 0250 Department of Legal Medicine
Faculty
Title Name Field of Specialization Associate Professor WANG Lu elaine Tumor pathology, Endocrine pathology, Forensic pathology Assistant Professor TAKEICHI Toshiaki ER-stress, Drug Dependence
Keywords of Research
drug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K,
Outline of Research
Mechanism of methamphetamine abuse Immunohistochemical analysis of brain damage in foreusic autopy cases Application of proteinase K for diatome detection in the diagnosis of drowning
24 0260 Department of Medical Education
Faculty
Title Name Field of Specialization medical education, clinical neurology, clinical sleep medicine, Professor HORI Ariyuki neurophysiology, medical informatics, problem-based learning undergraduate clinical teaching, graduate education of physicians, Professor YASUDA Yukio medical education Senior Assistant Professor TAKAMURA Akiteru Comunity-based Medical Education, Simulated education medical informatics, electronic medical record system, medical Senior Assistant Professor KURODA Naohiro educatin
Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL,
Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training course before medical practice, management of medical informatics, practical training course using simulators, developing new assessment for students’ practice, and providing new educational environment using e-shyllabi.
Publications
Originals 0260B001 A.Takamura, K.Ie, Y.Takemura:Overcoming challenges in primary care education: a trial of a longitudinal integrated clerkship in a rural community hospital setting in Japan., Education for Primary Care, 26:2;122-126,
2015.
Reviews
0260C001 A.Takamura:The present circumstance of primary care in Japan, Quality in Primary Care, 23:4;262-266, 2015.
0260C002 A.Takamura:Community-based medical edusation for undergraduates -Importance of introducing longitudinal
integrated clerkship, Consortium for Education of Generalist, 7:98-102, 2015.
25
Clinical Medicine
0300 Department of Cardiology
Faculty
Title Name Field of Specialization Professor KAJINAMI Koji Atherosclerosis, lipid metabolism Professor KITAYAMA Michihiko Ischemic heart disease, Coronary intervention Associate Professor KAWAI Yasuyuki Ischemic heart disease, Coronary intervention Associate Professor TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention Associate Professor AKAO Hironobu Ischemic heart disease, Coronary intervention Associate Professor FUJIOKA Nakaba Arrhythmia, Catheter ablation Assistant Professor MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention Assistant Professor WAKASA Minoru Heart failure Assistant Professor ISHIDA Ryoko Ischemic heart disease, Coronary intervention Assistant Professor IWADARE Mizuho Atherosclerosis, hypertension Assistant Professor SAITO Ryuhei Ischemic heart disease, Coronary intervention Assistant Professor AOKI Hirofumi Heart failure Assistant Professor TANABE Kan Heart failure FUJIBAYASHI Assistant Professor Arrhythmia, Catheter ablation Kousuke Assistant Professor WATANABE Makoto Ischemic heart disease, Coronary intervention Assistant Professor TAKEDA Kenji Molecular Biology
Keywords of Research
heart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease, autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT, myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP, microvascular angina, gene polymorphism, circadian variation
Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases ２ Development of new therapeutics using the gene expression modification or the stem cell research technique ３ Visualization and quantification of the biological signal in cardiovascular system
26 Publications
Originals 0300B001 (O.Iida), M.Nakamura, Y.Yamauchi, M.Fukunaga, Y.Yokoi, H.Yokoi, Y.Soga, K.Zen, S.Kan, N.Suematsu, N.Inoue, K.Suzuki, K.Hirano, Y.Shintani, Y.Miyashita, K.Urasawa, I.Kitano, T.Tsuchiya, K.Kawamoto, T.Yamaoka, M.Uesugi, T.Shinke, Y.Oba, N.Ohura, M.Uematsu, M.Takahara, T.Hamasaki, A.Nanto, OLIVE Investigators:3- year outcomes of the olive registry, a prospective multicenter study of patients with critical limb ischemia. A prospective, multi-center, three-year follow-up study on endovascular treatment for infra-inguinal vessel in
patients with critical limb ischemia, JACC-Cardiovascular Interventions, 8:11;1493-1502, 2015.
0300B002 T.Tsuchiya, O.Iida, T.Shiraki, Y.Soga, K.Hirano, K.Suzuki, T.Yamaoka, Y.Miyashita, M.Kitayama, K.Kajinami:Clinical characteristics of patients with Rutherford category IV, compared with V and VI, SAGE open
medicine, 3:2050312115597087, 2015.
Presentations at Conference
International Conference (Presentations) 0300I001 H.Akao, M.Watanabe, R.Saito, M.Wakasa, A.Motoyama, R.Ishida, T.Tsuchiya, Y.Kawai, M.Kitayama, K.Kajinami: In Vivo Evidence of Matrix Metalloproteinases(MMPs)and Vascular Inflammation: Coronary Rotational Atherectomy
Study, ISA2015, Amsterdam, 2015.
0300I002 M.Wakasa, H.Aoki, K.Fujibayashi, Y.Kawai, K.Kajinami:Association of plasma taurine levels with left ventricular
function in patients with idiopathic dilated cardiomyopathy, HEART FAILURE 2015, Sevilla, 2015.
0300I003 K.Kajinami, K.Yamamoto, M.Sasagawa, A.Nakagawa:Homocystein-lowering effects of VCRESC?(a vitamin
micronutrient beverage)in patients with coronary artery disease, ISA2015, Amsterdam, 2015.
0300I004 K.Fujibayashi, Y.Kawai, W.Fujita, S.Takano, T.Takamura, M.Watanabe, K.Tanabe, M.Wakasa, M.Kitayama, K.Kajinami:Increased level of circulating glutamate and cystine in patients with coronary vasospastic angina, ESC
CONGRESS 2015, London, 2015.
27 0310 Department of Respiratory Medicine
Faculty
Title Name Field of Specialization Professor TOGA Hirohisa clinical respiratory medicine, sleep disordered breathing Professor OSANAI Kazuhiro lung cell and molecular biology, COPD Professor ISHIZAKI Takeshi Associate Professor MIZUNO Shiro lung cell and molecular biology，COPD Associate Professor IGUCHI Masaharu Respiratory Medicine (Additional Post) TAKAHASHI Senior Assistant Professor clinical respiratory medicine, pulmonary tuberculosis Masakatsu Senior Assistant Professor OIKAWA Taku clinical respiratory medicine, lung cancer Senior Assistant Professor NAKAGAWA Ken clinical respiratory medicine, lung cancer Assistant Professor FUJIMOTO Yuki clinical respiratory medicine Assistant Professor KOJIMA Koji clinical respiratory medicine Assistant Professor SAITO Masatoshi clinical respiratory medicine, sleep，sleep disordered breathing Assistant Professor TAKAHARA Yutaka clinical respiratory medicine Assistant Professor KOBAYASHI Makoto lung cell and molecular biology Assistant Professor KAMEDA Mari Assistant Professor SHINOMIYA Shohei clinical respiratory medicine
Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection technique, lung cancer, apoptosis
Outline of Research
1. Pathogenesis and therapy of acute lung injury 2. Cell biology of pulmonary alveolar epithelium 3. Pathogenesis and therapy of sleep-disordered breathing 4. Cell biology of lung cancer cells
Publications
Originals 0310B001 M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.Toga:Pulmonary vascular and airway responses to systemic vasoconstrictors in anesthetized BALB/c mice. , Journal of cardiovascular
pharmacology, 65:4;325-334, 2015.
0310B002 (J.Gomez-Arroyo), M.Sakagami, AA.Syed, L.Farkas, BV.Tassell, D.Kraskauskas, S.Mizuno, A.Abbate, HJ.Bogaard, PR.Byron, NF.Voelkel:Iloprost reverses established fibrosis in experimental right ventricular failure,
European Respiratory Journal, 45:2;449-462, 2015.
28 0310B003 S.Mizuno, T.Ishizaki, H.Toga, A.Sakai, J.Isakova, E.Taalaibekova, Z.Baiserkeev, B.Kojonazarov, A.Aldashev: Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks, Biomed Research International,
2015:1-6, 2015.
0310B004 T.Ishizaki, S.Mizuno, A.Sakai, S.Matsukawa, B.Kojonazarov, B.Zamirbek, Y.Umeda, M.Morikawa, M.Anzai, T.Ishizuka, A.Aldashev:Blunted Activation of Rho-Kinase in Yak Pulmonary Circulation, Biomed Research
International, 2015:1-5, 2015.
0310B005 (S.Cheng), H.Chen, A.Wang, M.Xie, J.Xie, K.Osanai, J.Zhao, Y.Xu, W.Xiong, M.Zhou:Lentiviral vector-mediated delivery of lysophatidylcholine acyltransferase 1 attenuates airway inflammation in ovalbumin-induced allergic
asthmatic mice, Asian Pacific Journal of Allergy and Immunology, 33:4;320-329, 2015.
Reviews 0310C001 S.Mizuno, HJ.Bogaard, T.Ishizaki, H.Toga:Role of p53 in lung tissue remodeling, World Journal of Respirology,
5:1;40-46, 2015.
Case Reports 0310D001 T.Oikawa, R.Kato, S.Kitadate, S.Shinomiya, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga:ABPA-like Clinical Condition Associated with Bronchial Stenosis After Lung Lobectomy, The
Journal of the Japan Society for Rsepiratory Endoscopy, 37:2;203-208, 2015.
0310D002 Y.Takahara, K.Nakase, M.Nojiri, R.Kato, S.Shinomiya, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa, S.Mizuno, K.Osanai, H.Toga:A Case of Pulmonary Langerhans Cell Histiocytosis Diagnosed by a Cell Block from Bronchoalveolar Lavage Fluid, The Journal of the Japan Society for Respiratory Endoscopy, 37:2;240-244, 2015.
0310D003 R.Kato, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, H.Minato:A case of NUT midline carcinoma of the lung, Japanese
Journal of Lung Cancer, 55:7;1080-1085, 2015.
Presentations at Conference
International Conference (Presentations) 0310I001 S.Shinomiya, M.Nojiri, K.Nakase, R.Kato, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa, S.Mizuno, K.Osanai, T.Shibamoto, H.Toga:Nitric oxide and β2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice, Pulmonary vascular research
institute, China, 2015.
0310I002 S.Mizuno, R.Kato, M.Kobayashi, K.Nakagawa, T.Oikawa, K.Osanai, T.Ishizaki, H.Toga:Circulating vascular endothelial cell gene expressions in chronic obstructive pulmonary disease, ATS 2015 International Conference,
Denver, 2015.
0310I003 K.Osanai, M.Zhou, M.Nojiri, K.Nakase, R.Kato, M.Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno, H.Toga:Exogenous expression of lysophosphatidylcholine acyltransferase 1 attenuates alveolar type II cell
apoptosis in oleic acid-induced acute lung injury in rats, ATS 2015 International Conference, Denver, 2015.
0310I004 K.Osanai, M.Zhou, M.Nojiri, K.Nakase, R.Kato, M,Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno, H.Toga:Exogenous expression of lysophosphatidylcholine acyltransferase 1 attenuates alveolar type II cell
apoptosis in oleic acid-induced acute lung injury in rats, ATS 2015 International Conference, Denver, 2015.
29 0320 Department of Gastroenterology
Faculty
Title Name Field of Specialization Professor ARISAWA Tomiyasu Gastro-intestinal disorders Associate Professor SHIMASAKI Takeo Molecular Oncology, Pancreatic cancer , tissue engineering． (Additional Post) NAKAMURA Senior Assistant Professor Endoscopic thcrapy of early gastric cancer Masakatsu Senior Assistant Professor OTSUKA Toshimi Clinico-pathological study of nonalcoholic steatohepatitis Assistant Professor HAYASHI Ranji Inflammatory Bowel Disease Assistant Professor NOMURA Tomoe Gastro-intestinal disorders
Keywords of Research
alcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholic steatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment, treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis
Outline of Research
１ Basic and clinical study of digestive disease ①Treatment for esophageal and gastric varices associated with portal hypertension ②Endoscopic treatment for early cancer of the esophagus, stomach and colon ③Hepatic support system for severe alcoholic hepatitis ④Clinical feature and treatment for nonalcoholic steatohepatitis ２ Experimental study of alcoholic organ injury ①Pathogenesis and treatment for alcoholic hepatitis ②Pathogenesis of hepatic fibrosis induced by alcohol ③Effect of alcohol on chemical carcinogenesis of the liver ④Pathogenesis for nonalcoholic steatohepatitis
Publications
Originals 0320B001 N.Kawada, H.Uehara, T.Hosoki, M.Takami, H.Shiroeda, T.Arisawa, Y.Tomita:Usefulness of Dual-Phase F-18-
FDG PET/CT for Diagnosing Small Pancreatic Tumors, Pancreas, 44:4;655-659, 2015.
0320B002 M.Nakamura, T.Tahara, H.Shiroeda, K.Matsunaga, T.Otsuka, J.Yonemura, T.Shibata, T.Arisawa:The effect of short-term proton pump inhibitor plus anti-ulcer drug on the healing of endoscopic submucosal dissection-derived
artificial ulcer: A randomized controlled trial, Hepato-Gastroenterology, 62:137;219-224, 2015.
0320B003 (T.Tahara), T.Shibata, M.Okubo, T.Kawamura, K.Sumi, T.Ishizuka, M.Nakamura, M.Nagasaka, Y.Nakagawa, N.Ohmiya, T.Arisawa, I.Hirata:Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its
relationship to the severe clinical phenotypes, Clinical and Experimental Medicine, 15:3;327-332, 2015.
30 0320B004 (T.Tahara), T.Shibata, T.Kawamura, M.Okubo, Y.Ichikawa, K.Sumi, M.Miyata, T.Ishizuka, M.Nakamura, M.Nagasaka, Y.Nakagawa, N.Ohmiya, T.Arisawa, I.Hirata:Fusobacterium detected in colonic biopsy and
clinicopathological features of ulcerative colitis in Japan, Digestive Diseases and Sciences, 60:1;205-210, 2015.
0320B005 (T.Tahara), T.Arisawa:DNA methylation as a molecular biomarker in gastric cancer, Epigenomics, 7:3;475-486,
2015.
0320B006 (T.Tahara), T.Shibata, M.Okubo, T.Ishizuka, T.Kawamura, H.Yamashita, M.Nakamura, Y.Nakagawa, M.Nagasaka, T.Arisawa, N.Ohmiya, I.Hirata:Association between interleukin-1 beta and tumor necrosis factor-alpha
polymorphisms and symptoms of dyspepsia, Molecular Medicine Reports, 11:5;3888-3893, 2015.
0320B007 (T.Shibata), M.Nakamura, T.Omori, T.Tahara, Y.Ichikawa, M.Okubo, T.Ishizuka, Y.Nakagawa, M.Nagasaka, M.Nakamura, T.Arisawa, I.Hirata:Association between individual response to food taste and gastroesophageal
symptoms, Journal of Digestive Diseases, 16:6;337-341, 2015.
0320B008 Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George:Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, PLoS
One, 10:3;e0118744, 2015.
31 0330 Department of Nephrology
Faculty
Title Name Field of Specialization Clinicopathological study of nephritic and nephrotic syndrome, Professor YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renal transplantation Professor(Additional Post) TOMOSUGI Naohisa Proteomics in clinical nephrology Senior Assistant Professor YAMAYA Hideki Clinical nephrology Senior Assistant Professor ADACHI Hiroki Clinical nephrology Assistant Professor IMURA Junko Clinical nephrology CHIKAZAWA Assistant Professor Clinical nephrology Yoshihiro Assistant Professor NAKAGAWA Masaru Clinical nephrology Assistant Professor HAYAMA Satoshi Clinical nephrology Assistant Professor FUJIMOTO Keiji Clinical nephrology Assistant Professor MATSUI Yuki Clinical nephrology Assistant Professor HAYASHI Norifumi Clinical nephrology Assistant Professor OKINO Kazuaki Clinical nephrology Assistant Professor MUKAI Kiyotaka Clinical nephrology Assistant Professor OKUSHI Yuki Clinical nephrology
Keywords of Research
acquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype, metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation, hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure, survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD
Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases (CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population. As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal works of various research fields.
32 Publications
Originals 0330B001 Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.
0330B002 (M.Kuroda), M.Shimizu, N.Inoue, I.Ikeno, H.Nakagawa, A.Yokoi, Y.Niida, M.Konishi, H.Kaneda, N.Igarashi, J.Yamahana, H.Taneichi, H.Kanegane, M.Ito, S.Saito, K.Furuichi, T.Wada, M.Nakagawa, H.Yokoyama, A.Yachie:Serum tau protein as a marker of disease activity in enterohemorrhagic Escherichia coli O111-induced
hemolytic uremic syndrome, Neurochemistry International, 85-86:24-30, 2015.
0330B003 (S.Kitajima), K.Furuichi, N.Sakai, A.Sagara, Y.Shinozaki, T.Toyama, Y.Iwata, M.Shimizu, H.Yokoyama, S.Kaneko, T.Wada:Relapse and its remission in Japanese patients with idiopathic membranous nephropathy, Clinical and
Experimental Nephrology, 19:2;278-283, 2015.
0330B004 Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.
0330B005 (M.Horio), E.Imai, Y.Yasuda, T.Watanabe, H.Yokoyama, H.Makino, S.Matsuo:Serum albumin, but not glycated albumin was a potent factor affecting the performance of GFR equation based on serum creatinine, Clinical and
Experimental Nephrology, 19:2;284-292, 2015.
0330B006 (Y.Yonekura), S.Goto, H.Sugiyama, H.Kitamura, H.Yokoyama, S.Nishi:The influences of larger physical constitutions including obesity on the amount of urine protein excretion in primary glomerulonephritis: research of
the Japan Renal Biopsy Registry, Clinical and Experimental Nephrology, 19:3;359-370, 2015.
0330B007 H.Yokoyama, H.Sugiyama, i.Narita, T.Saito, K.Yamagata, S.Nishio, S.Fujimoto, N.Mori, Y.Yuzawa, S.Okuda, S.Maruyama, H.Sato, Y.Ueda, H.Makino, S.Matsuo:Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR), Clinical and Experimental Nephrology,
19:3;496-505, 2015.
0330B008 (Muso, Eri);Mune, Masatoshi;Hirano, Tsutomu;Hattori, Motoshi;Kimura, Kenjiro;Watanabe, Tsuyoshi;Yokoyama, Hitoshi;Sato, Hiroshi;Uchida, Shunya;Wada, Takashi;Shoji, Tetsuo;Yuzawa, Yukio;Takemura, Tsukasa;Sugiyama, Satoshi;Nishizawa, Yoshiki;Ogahara, Satoru;Yorioka, Noriaki;Sakai, Soichi;Ogura, Yosuke;Yukawa, Susumu;Iino, Yasuhiko;Imai, Enyu;Matsuo, Seiichi;Saito, Takao:Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study,
Clinical and Experimental Nephrology, 19:3;379-386, 2015.
0330B009 K.Fujimoto, J.Imura, H.Atsumi, Y.Matsui, H.Adachi, H.Okuyama, H.Yamaya, H.Yokoyama:Clinical significance of serum and urinary soluble urokinase receptor (suPAR) in primary nephrotic syndrome and MPO-ANCA-associated
glomerulonephritis in Japanese, Clinical and Experimental Nephrology, 19:5;804-814, 2015.
0330B010 (M.Horio), E.Imai, Y.Yasuda, T.Watanabe, H.Yokoyama, H.Makino, S.Matsuo:Effects of serum albumin and glycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C, Clinical and
Experimental Nephrology, 19:4;626-630, 2015.
0330B011 (E. Muso), M.Mune, T.Hirano, M.Hattori, K.Kimura, T.Watanabe, H.Yokoyama, H.Sato, S.Uchida, T.Wada, T.Shoji, T.Takemura, Y.Yuzawa, S.Ogahara, S.Sugiyama, Y.Iino, S.Sakai, Y.Ogura, S.Yukawa, Y.Nishizawa, N.Yorioka, E.Imai, S.Matsuo, T.Saito:A prospective observational survey on the long-term effect of LDL apheresis
on drug-resistant nephrotic Syndrome, Nephron Extra, 5:2;58-66, 2015.
0330B012 Y.Matsui, Y.Sunatani, N.Hayashi, K.Okino, Y.Okushi, K.Mukai, H.Adachi, H.Yamaya, K.Iwabuchi, H.Yokoyama:DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts, Clinical and
Experimental Nephrology, 20:3;479-488, 2015.
0330B013 N.Hayashi, S.Akiyama, H.Okuyama, Y.Matsui, H.Adachi, H.Yamaya, S.Maruyama, E.Imai, S.Matsuo, H.Yokoyama:Clinicopathological characteristics of M-type phospholipase A2 receptor (PLA2R)-related
membranous nephropathy in Japanese, Clinical and Experimental Nephrology, 19:5;797-803, 2015.
33 0330B014 K.Fujimoto, J.Imura, H.Adachi, H.Yamaya, H.Yokoyama:Soluble urokinase receptor in primary focal segmental
glomerulosclerosis , Journal of Kanazawa Medical University, 40:2・3;47-53, 2015.
Reviews
0330C001 H.Yokoyama:Epidemiology of nephrotic syndrome in adult and elderly Japanese, 252:11;1139-1144, 2015.
Case Reports 0330D001 Y.Sakata, A.Kitayama, R.Yoshimura, K.Anzawa, T.Fujii, K.Fujimoto, H.Yokoyama, T.Mochizuki:Case of cutaneous phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient, Journal of Dermatology,
42:3;263-266, 2015.
Presentations at Conference
International Conference (Presentations) 0330I001 Y.Matsui, Y.Sunatani, K.Iwabuchi, H.Yokoyama:DNA double strand breaks accelerated collagen type VI secretion
of glomerular endothelial cells, ERA-EDTA Congress in Amsterdam The Netherlands, London, 2015.
0330I002 H.Adachi, Y.Matsui, N.Hayashi, K.Fujimoto,J.Imura, H.Yamaya, H.Yokoyama:Adiponectin fractions influences the development of cardiovascular disease in Japanese renal transplant recipients, The Annual of American Sociey of
Nephrology, San Diego, 2015.
0330I003 Y.Matsui, N.Hayashi, J.Imura, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:DNA double strand breaks induced collagen type VI secretion of glomerular endothelial cells in renal allografts, The Annual of American Sociey of
Nephrology, San Diego, 2015.
0330I004 K.Fujimoto, Y.Matsui, N.Hayashi, J.Imura, H.Adachi, H.Yamaya, H.Yokoyama:Urinary and serum soluble urokinase receptor levels predicts the therapeutic response of nephrotic syndrome, The Annual of American Sociey
of Nephrology, San Diego, 2015.
0330I005 (K.Hiromura), K.Kayakabe, H.Ikeuchi, H.Sugiyama, M.Nagata, H.Sato, H.Yokoyama, Y.Nojima:Clinical and Histological Features of Lupus Nephritis in Japan: An Analysis of the Japan Renal Biopsy Registry (J-RBR), The
Annual of American Sociey of Nephrology, San Diego, 2015.
0330I006 (M.Horio), E.Imai, Y.Yasuda, T.Watanabe, H.Yokoyama, H.Makino, S.Matsuo:Effect of Glycemic Control on Estimated Glomerular Filtration Rate by Cystatin C, The Annual of American Sociey of Nephrology, San Diego,
2015.
34 0340 Department of Diabetology and Endocrinology
Faculty
Title Name Field of Specialization Professor KOYA Daisuke diabetes, hypertension, obesity, aging Associate Professor NAKAGAWA Atsushi diabetes, pituitary diseases Associate Professor NISHIZAWA Makoto diabetes, insulin secretion, thyroid diseases Associate Professor KANASAKI Keizo diabetes, hypertenstion, obesity, preeclampsia Associate Professor KITADA Munehiro diabetes, diabetical renal disease, hypertension Senior Assistant Professor KONISHI Kazunori diabetes, arteriosclerosis Senior Assistant Professor TSUDA Shinichi diabetes, hypertension, arteriosclerosis Assistant Professor KANASAKI Megumi diabetes, hypertension, obesity, preeclampsia
Keywords of Research
diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa, transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring, hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial gene mutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy
Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stress- induced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1 under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic complications. Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on the metabolic syndrome and blood pressure pattern to find out the participation of adiponectin. We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose homeostasis.
Publications
Originals 0340B001 (M.Yasuda-Yamahara), S.Kume, K.Yamahara, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya, M.Haneda, S.Ugi, H.Maegawa, T.Uzu:Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via
enhancing energy expenditure, Biochemical and Biophysical Research Communications, 465:2;249-255, 2015.
0340B002 S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya:Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney International., 88:3;479-489,
2015.
35 0340B003 (S.Araki), M.Haneda, D.Koya, K.Kondo, S.Tanaka, H.Arima, S.Kume, J.Nakazawa, M.Chin-Kanasaki, S.Ugi, H.Kawai, H.Arai, T.Uzu, H.Maegawa:Urinary potassium excretion and renal and cardiovascular complications in patients with type 2 diabetes and normal renal function, Clinical journal of the American Society of Nephrology :
CJASN., 10:12;2152-2158, 2015.
0340B004 (S.Kato), S.Maruyama, H.Makino, J.Wada, D.Ogawa, T.Uzu, H.Araki, D.Koya, K.Kanasaki, Y.Oiso, M.Goto, A.Nishiyama, H.Kobori, E.Imai, M.Ando, S.Matsuo:Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial, Clinical and Experimental Nephrology, 19:6;1098-
1106, 2015.
0340B005 (Y.Tanaka), S.Kume, H.Araki, J.Nakazawa, M.Chin-Kanasaki, S.Araki, F.Nakagawa, D.Koya, M.Haneda, H.Maegawa, T.Uzu:1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney
proximal tubular cell, Free Radical Biology & Medicine., 89:831-841, 2015.
Reviews 0340C001 T.Nagai, K.Nitta, M.Kanasaki, D.Koya, K.Kanasaki:The biological significance of angiotensin-converting enzyme
inhibition to combat kidney fibrosis, Clinical and Experimental Nephrology, 19:1;65-74, 2015.
0340C002 (M.Haneda), K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino, K.Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda, K.Ichikawa, K.Shide:A new classification of diabetic nephropathy 2014: a report from joint committee on diabetic nephropathy, Journal of Diabetes
Investigation, 6:2;242-246, 2015.
0340C003 N.Ueki, S.Takeda, D.Koya, K.Kanasaki:The relevance of the renin-angiotensin system in the development of drugs
to combat preeclampsia, International Journal of Endocrinology [Electronic Resource], 2015:572713;1-12, 2015.
0340C004 Kidney fibrosis and endothelial injury, The japanese journal of Nephrology, 57:7;1200-1205, 2015.
0340C005 K.Nitta, M.kanasaki, K.Kanasaki, D.koya:The role of angiotensin-converting enzyme inhibition to cimbat kidney
fibrosis, Journal of Kanazawa Medical University, 40:2・3;131-138, 2015.
0340C006 Diagnosis and management of diabetic nephropathy, Nihon Rinsyo, 73:12;2037-2043, 2015.
0340C007 (S.Kume), D.Koya:Autophagy: A novel therapeutic target for diabetic nephropathy, Diabetes & Metabolism
Journal., 39:3;451-460, 2015.
Case Reports 0340D001 Y.Sasagawa, O.Tachibana, A.Nakagawa, D.Koya, H.Iizuka:Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma, Journal of Clinical Neuroscience,
22:3;601-603, 2015.
Short Communications 0340E001 D.Koya:Epidermal growth factor receptor signaling and the progression of diabetic nephropathy, Journal of
Diabetes Investigation, 6:5;519-521, 2015.
Presentations at Conference
International Conference (Synposium) 0340H001 D.Koya:S21 Diabetic complications The role of autophagy in diabetic nephropathy, The Korean Society for
Biochemistry and Molecular Biology International Conference 2015, Seoul, 2015.
0340H002 D.Koya:Symposium12 Diverse cell signaling in metabolic syndrome High fat diet-induced hepatosteatosis was ameliorated by the treatment with ketogeic amino acid, 2015 International Congress on Obesity and Metabolic
Syndrome in conjunction with the 43rd Annual Scientific Meeting of KSSO, Seoul, 2015.
36
International Conference (Presentations) 0340I001 K.Kanasaki, S.Shi, M.Kanasaki, D.Koya:The interaction between DPP-4 and intergrin β1 regulates the signaling responsible for induction of the endothelial to mesenchymal transition in diabetic kidney, American Diabetes
Association 74th Scientific Sessions, Boston, 2015.
37 0350 Department of Hematology and Immunology
Faculty
Title Name Field of Specialization Professor MASAKI Yasufumi Hematology and Immunology, Transfusion Medicine Professor OKAZAKI Toshiro Hematology and Immunology, Hematology/Oncology FUKUSHIMA Associate Professor Hematology and Immunology, Clinical Parmacology Toshihiro Associate Professor TANAKA Masao Rheumatology, Immunology Senior Assistant Professor KAWANAMI Takafumi Hematology and Immunology Senior Assistant Professor FUJITA Yoshimasa Rheumatology, Immunology Senior Assistant Professor OGISO Hideo Hematology and Immunology Assistant Professor KAWANAMI Haruka Hematology and Immunology Assistant Professor SAKAI Tomoyuki Hematology and Immunology Assistant Professor NAKAJIMA Akio Hematology and Immunology Assistant Professor NAKAMURA Takuji Hematology and Immunology Assistant Professor MIKI Miyuki Hematology and Immunology Assistant Professor UEDA Yoshibumi Hematology and Immunology Assistant Professor FURUMOTO Hidehiro Hematology and Immunology Assistant Professor HASHIZUME Chieko Hematology and Immunology
Keywords of Research
autoimmune disorder, Sjogren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus,
Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic research in the fields of Hematology and Immunology. Studies of immunological abnormalities and pathophysiology of autoimmune diseases: 1 Effects of chemokines on vascular injury and Th1 response during chronic inflammation. 2 Function of microdomain (lipid rafts) on lymphocyte activation and its contribution in autoimmune diseases. 3 Analysis of immunological disorder in sphingomyelin knockout mice. 4 Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis. 5 Detection of stem cells in salivary glands and its implication for regenerative medicine.
Studies of hematological malignancies and development of anti-cancer drugs: 1 Analysis of EB-virus proteins and their roles in lymphoproliferative disorders. 2 Molecular biological analysis of drug resistance. 3 Roles of sphingomyelin on apoptosis. 4 Roles of SMS on niche of leukemia stem cells.
38 Books
0350A001 (J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn:Unraveling the specific role of sphingomyelins in cell physiology: Where are we?, Sphingolipids: Biology, Synthesis and Functions
(Angel Catalá), 91-128, America, 2015.
0350A002 (H.Sawai), M.Taniguchi, T.Okazaki:Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders, Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao,
Lina Marie Obeid), 23-51, Bundesrepublik Deutschland, 2015.
Publications
Originals 0350B001 T.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.Ueda:Prospective clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku
Hematology Oncology Study Group, Medical Oncology, 32:232-238, 2015.
0350B002 (H.Sawai), H.Ogiso, T.Okazaki:Differential changes in sphingolipids between TNF-induced necroptosis and
apoptosis in U937 cells and necroptosis-resistant sublines, Leukemia Research, 39:964-970, 2015.
0350B003 (T.Nakane), K.Tamura, M.Hino, T.Tamaki, I.Yoshida, T.Fukushima, Y.Tatsumi, Y.Nakagawa, K.Hatanaka, T.Takahashi, N.Akiyama, M.Tanimoto, K.Ohyashiki, A.Urabe, T.Masaoka, A.Kanamaru, Japan Febrile Neutropenia Study:Cefozopran, meropenem, or imipenem-cilastatin compared with cefepime as empirical therapy in febrile neutropenic adult patients: A multicenter prospective randomized trial, Journal of Infection and Chemotherapy,
21:1;16-22, 2015.
0350B004 T.Satoh-Nakamura, N.Kurose, T.Kawanami, T.Nakamura, H.Iwao-Kawanami, A.Nakajima, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki:CD14+ follicular dendritic cells in lymphoid follicles may play a role in
the pathogenesis of IgG4-related disease, Biomedical Research, 36:2;143-153, 2015.
0350B005 M.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.Okazaki:Lysososomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in
natural killer/T lymphoma cell apoptosis, Cell Death and Disease, 6:e1717;1-12, 2015.
0350B006 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.
0350B007 (H.Yazama), K.Kitatani, K.Fujiwara, M.Kato, M.Hashimoto-Nishimura, K.Kawamoto, K.Hasegawa, H.Kitano, A.Beilawska, J.Bielawski, T.Okazaki:Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide,
International Journal Clinical Oncology, 20:3;438-446, 2015.
0350B008 (A.Khosroshahi), Z.S.Wallace, J.L.Crowe, T.Akamizu, A.Azumi, M.N.Carruthers, S.T.Chari, E.Della-Torre, L.Frulloni, H.Goto, P.A.Hart, T.Kamisawa, S.Kawa, M.Kawano, M.H.Kim, Y.Kodama, K.Kubota, M.M.Lerch, M.Löhr, Y.Masaki, S.Matsui, T.Mimori, S.Nakamura, T.Nakazawa, H.Ohara, K.Okazaki, T.H.Ryu, T.Saeki, N.Schleinitz, A.Shimatsu, T.Shimosegawa, H.Takahashi, M.Takahira, A.Tanaka, M.Topazian, H.Umehara, G.J.Webster, T.E.Witzing, M.Yamamoto, W.Zhang, T.Chiba, J.H.Stone:International consensus guidance statedment on the management and treatment of IgG4-related disease, Arthritis & Rheumatology, 67:7;1688-1699,
2015.
0350B009 H.Ogiso, M.Taniguchi, T.Okazaki:Analysis of lipid-composition changes in plasma membrane microdomains, Journal of Lipid Research, 56:8;1594-1605, 2015.
39
Reviews 0350C001 (K.Kitatani), M.Taniguchi, T.Okazaki:Role of sphingolipids and metabolizing enzymes in hematological
malignancies, Molecules and Cells, 38:6;482-495, 2015.
0350C002 Y.Masaki, H.Shimizu, T.Nakamura(Satoh), T.Nakamura, A.Nakajima, H.Kawanami(Iwao), T.Kawanami, K.Yamada, Y.Hamaguchi, M.Kawano, Y.Fujita, T.Fukushima:Diagnosis and treatment of IgG4-related disease-Including IgG4-
related skin disease-, Journal of Environmental Dermatology and Cutaneous Allergology, 9:4;212-217, 2015.
Case Reports 0350D001 H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai, T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.
0350D002 (H.Yohida), N.Yasuda, T.Hayashi, K.Tujii, M.Wato, S.Gamoh, K.Shimizutani, A.Tanaka, Y.Masaki, S.Morita:A case of probable IgG4-related disease involving the unilateral trigeminal nerve of the cheek region, Oral Radiology,
31:193-198, 2015.
Others 0350F001 (T.Narita), A.Inagaki, T.Kobayashi, Y.Kuroda, T.Fukushima, M.Nezu, S.Fuchida, H.Sakai, N.Sekiguchi, I.Sugiura, Y.Maeda, H.Takamatsu, N.Tsukamoto, D.Maruyama, Y.Kubota, M.Kojima, K.Sunami, T.Ono, M.Ri, K.Tobinai, S.Iida:t(14;16)-positive multiple myeloma shows negativity for CD56 expression and unfavorable outcome even in
the era of novel drugs, Blood Cancer Journal, 5:e285, 2015.
Presentations at Conference
International Conference (Key Note Lecture) 0350G001 T.Okazaki:Role of membrane lipids, sphingomyelin and ceramide in tumor cell growthi, migration and death.,
Cancer science institute of singapore, Singapore, 2015.
International Conference (Presentations) 0350I001 T.Okazaki, L.O.Waedhani, M.Hashimoto, K.Kitatani, H.Ogiso, Y.Ueda, M.Taniguchi:Enhancement of infiltration of malignant lymphoma cells in the mouse liver by sphingomyelin deficiency through sphingomyelin synthase2 (SMS2),
56th International Conference on the Bioscience of lipids, Puerto Iguzu, 2015.
0350I002 (K.Miura),J. Konishi, T.Miyake, M.Masanori, A.Hojo, Y.Masaki, M.Uno, J.Ozaki, C.Yoshida, D.Niiya, K.Kitazume, Y.Maeda, J.Takizawa, R.Sakai, Y.Nawa, T.Yano, K.Yamamoto, K.Sunami, Y.Hiramatsu, K.Aoyama, H.Tsujimura, T.Hatta, M.Kanno:2680 a new prognostic model for elderly patients with diffuse large B-cell lymphoma treated with
R-CHOP, 57th Annual Meeting & Exposition, Orlando, 2015.
40 0360 Department of Neurology
Faculty
Title Name Field of Specialization Professor MATSUI Makoto Clinical neurology, Neuroimmunology, Clinical Immunology Professor(Additional Post) TANAKA Keiko Clinical neurology, Neuroimmunology Associate Professor TOMIOKA Ryo Clinical neurology, Neuroimmunology Associate Professor NAGAYAMA Shigemi Clinical neurology, Neuroimmunology Senior Assistant Professor SANADA Mitsuru Clinical neurology, Neurophysiology Assistant Professor FUJITA Michiyo Clinical neurology Assistant Professor NAKANISHI Megumi Clinical neurology, Neuroimmunology
Keywords of Research
clinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes, autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis,
Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animal models, which have been established due to recent advances in basic immunology.
Publications
Originals 0360B001 (N.Tachibana), M.Kinoshita, F.Kametani, K.Tanaka, Y.Une, Y.Komatsu, Y.Kobayashi, S.Ikeda:Expression of N- methyl-D-aspartate receptor subunits in the bovine ovum: Ova as a potential source of autoantigens causing anti- NMDAR encephalitis., The Tohoku Journal of Experimental Medicine, 235:3;223-231, 2015.
0360B002 (R.Matsuda), T.Kezuka, A.Umazume, Y.Okunuki, H.Goto, K.Tanaka:Clinical profile of anti-myeli oligodendrocyte glycoprotein antibody seropositive cases of optic neuritis., Neuro-Ophthalmology, 39:5;213-219, 2015.
0360B003 (H.Nakajima), M.Motomura, K.Tanaka, A.Fujikawa, R.Nakata, Y.Maeda, T.Shima, A.Mukaino, S.Yoshimura, T.Miyazaki, H.Shiraishi, A.Kawakami, A.Tsujino:Antibodies to myelin oligodendrocyte glycoprotein in idiopathic
optic neuritis, BMJ Open, 5:4;1-4, 2015.
0360B004 (RS.Tsuburaya), N.Miki, K.Tanaka, T.Kageyama, K.Irahara, S.Mukaida, K.Shiraishi, M.Tanaka:Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in a Japanese boy with recurrent optic neuritis, Brain &
Development, 37:1;145-148, 2015.
0360B005 Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.
41
Reviews 0360C001 K.Tanaka:Recent update on autoimmune encephalitis/encephalopathy, Clinical and Experimental
Neuroimmunology, 6:70-82, 2015.
Case Reports 0360D001 (R.Matsumoto), N.Mikuni, K.Tanaka, K.Usami, K.Fukao, T.Kunieda, Y.Takahashi, S.Miyamoto, H.Fukuyama, R.Takahashi, A.Ikeda:Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody,
Epileptic Disorders, 17:1;89-94, 2015.
0360D002 (H.Yaguchi), K.Tsuzaka, S.Shirai, M.Niino, T.Takahashi, K.Tanaka, I.Yabe, H.Sasaki:Importance of T1-MRI enhanced pyramidal tracts in differential diagnosis as to paraneoplastic encephalomyelitis, Clinical Neurology and Neurosurgery, 132:9-11, 2015.
0360D003 (R.Miyamoto), H.Sumikura, T.Takeuchi, M.Sanada, K.Fujita, T.Kawarai, H.Mure, R.Morigaki, S.Goto, S.Murayama, Y.Izumi, R.Kaji:Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar
atrophy, Neurology, 85:1522-1524, 2015.
Short Communications 0360E001 K.Tanaka:Debate on the pathogenesis of paraneoplastic cerebellar degeneration with anti-Yo antibody:T-cell
mediated or antibody mediated?, Clinical and Experimental Neuroimmunology, 6:3;222-224, 2015.
0360E002 (M.Tanaka), M.Kinoshita, K.Tanaka:Corticosteroid and tacrolimus treatment in neuromyelitis optica related
disorders., Multiple Sclerosis Journal, 21:5;669, 2015.
0360E003 （M.Tanaka）, M.Kinoshita, JF.Foley, K.Tanaka, J.Kira, WM.Carroll:Body weight-based natalizumab treatment in
adult patients with multiple sclerosis, Journal of neurology, 262:3;781-782, 2015.
0360E004 (M.Tanaka), M.Kinoshita, K.Tanaka:Anti-John Cunningham virus index in Japanese patients with multiple sclerosis
and neuromyelitis optica-related disorder., Clinical and Experimental Neuroimmunology, 6:3;309-311, 2015.
0360E005 M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada, M.Matsui:Intractable cough as Characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum
disorder., Multiple Sclerosis Journal, 22:4;576-577, 2015.
Others 0360F001 K.Tanaka:Pathogenesis of autoantibodies in autoimmune encephalopathies, Annual report of the Japan Epilepsy
Research Foundation, 26:83-90, 2015.
Presentations at Conference
International Conference (Synposium) 0360H001 K.Tanaka, Yongzhi Li, N.Kato:Memory disturbance in mice treated with intraventricular administration of CSF
from NMDAR-encephalitis patients, The Lancet Neurology Autoimmune Disorders Conference, Balcerona, 2015.
International Conference (Presentations) 0360I001 K.Tsutsui, M.Fujita, T.Kanbayashi, M.Matsui, K.Tanaka.:Clinical features of anti-NMDAR antibody-positive patients predominantly presenting with chronic psychosis and acute exacerbations., The Lancet Neurology
Autoimmune Disorders Conference, Balcerona, 2015.
42 0360I002 K.Tanaka, M.Fujita, K.Tsutsui, T.Kanbayashi, M.Matsui:Clinical Features of Anti-NMDAR Antibody-positive Patients Predominantly Presenting Chronic Psychosis with Acute Exacerbations, 67th AAN Annual Meeting,
Washington, 2015.
43 0363 Department of Medical Oncology
Faculty
Title Name Field of Specialization Professor MOTOO Yoshiharu Medical Oncology, Tumor Cell Biology, Gastroenterology Professor YASUMOTO Kazuo Gastric cancer, Cancerous peritonitis molecular target therapy Senior Assistant Professor HISAMURA Kazuho Social Work, Social Welfare, Psycho-Oncology
Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology,
Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperating with Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include the metabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the discovery of new molecular markers for pancreatic cancer.
Publications
Originals 0363B001 (T.Suzuki), A.Yamamoto, M.Ohsawa, Y.Motoo, H.Mizukami, T.Makino:Ninjin'yoeito and ginseng extract prevent
oxaliplatin-induced neurodegeneration in PC12 cells, Journal of Natural Medicines, 69:4;531-537, 2015.
0363B002 (K.Ohtsubo), H.Mouri, K.Yamashita, K.Yasumoto, D.Inoue, T.Gabata, H.Ikeda, H.Watanabe, S.Yano:Usefulness of EUS-guided fine needle aspiration in diagnosis of autoimmune pancreatitis., ENDOSCOPIC FORUM for digestive
disease, 31:2;125-134, 2015.
0363B003 Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, Y.Motoo, K.Miyazawa:Initial experience of enzalutamide in patients with castration resisitant prostate cancer, Journal of
Kanazawa Medical University, 40:2・3;196-200, 2015.
Reviews 0363C001 Y.Motoo:Gender difference in clinical practice for cancer patients, Japanese Journal of Clinical Medicine,
73:4;666-670, 2015.
Case Reports 0363D001 J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi:Effective treatment with Kampo medicines of
fibromyalgia that occurred after the mycoplasma infection, PAIN AND KAMPO MEDICINE, 25:129-133, 2015.
Others 0363F001 Y.Motoo:Description of Kampo medicines in the clinical practice guidelines for irritable bowel syndrome, Journal of
Gastroenterology, 50:7;816, 2015.
44
Presentations at Conference
International Conference (Synposium) 0363H001 Y.Motoo:Evidence Reports on Kampo Treatment (EKAT) and Kampo medicines in clinical practice guidelines (KCPG), The 10th International Congress of Complementary Medicine Research - ICCMR 2015, Jeju, 2015
0363H002 Y.Motoo,I.Arai,K.Tsutani:Systematic review on the use of Kampo diagnosis in randomized controlled trials of
Kampo medicines, 3rd International Symposium for Japanese Kampo Medicine (ISJKM), Vienna, 2015.
45 0366 Department of Infectious Diseases
Faculty
Title Name Field of Specialization Professor IINUMA Yoshitsugu Clinical Infectious Diseases, Infection Control and Prevention Clinical Infectious Diseases, Infection Control and Prevention, Associate Professor BABA Hisashi Clinical Microbiology Assistant Professor USUDA Daisuke Clinical Infectious Diseases, Infection Control and Prevention
Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs,
Outline of Research
1. Antimicrobial drug resistant bacilli infections 2. Infectious diseases in severe immunocompromised host 3. Acid-fast bacilli infections 4. Appropriate use of antimicrobial drugs
Publications
Originals 0366B001 Y.Tanaka, M.Matsumoto, C.Tanaka, S.Nakagawa, Y.Yanaida, K.Nagata, Y.Iinuma:Causes of presence of ammonium
urate crystals in urinary sediments, The Japanese journal of medical technology, 64:2;179-185, 2015.
0366B002 K.Kanaya, N.Izumiya, O.Kobayashi, S.Komichi, Y.Sakagami, Y.Ysujita, T.Nakagawa, E.Nakano, C.Nakamuro, A.Niikawa, S.Nishio, K.Masuoka, H.Baba, Y.Iinuma:Regional surveillance for the antimicrobial susceptibility of anaerobic Gram-negative rods in the Hokuriku district of Japan, The Journal of the Japanese Society for Clinical
Microbiology, 25:3;223-229, 2015.
0366B003 (M.Yamamoto), S.Takakura, Y.Iinuma, G.Hotta, Y.Matsumura, A.Matsushima, M.Nagao, K.Ogawa, Y.Fujimoto, A.Mori, Y.Ogura, T.Kaido, S.Uemoto, S.Ichiyama:Changes in surgical site infections after living donor liver
transplantation, PLoS One, 10:8;e0136559, 2015.
Case Reports 0366D001 M.Matsumoto, Y.Tanaka, C.Tanaka, S.Nakagawa, Y.Yanaida, K.Nagata, T.Fujiki, Y.Iinuma:Four pediatric cases of ammonium acid urate crystal with nephrotic syndrome, The Japanese journal of medical technology, 64:5;541-547,
2015.
46 0368 Department of General Internal Medicine
Faculty
Title Name Field of Specialization Lifestyle-related disease, Diabetes, Laboratory medicine, General Professor KOBAYASHI Junji medicine Associate Professor AKAZAWA Sumiyo gender specific medicine, hypertension, molecular biology Associate Professor YAMAKAWA Jun-ichi General medicine, Kampo medicine Associate Professor UENISHI Hiroaki Cardiovascular Medicine Senior Assistant Professor MORIYA Junji General medicine, Kampo medicine Senior Assistant TSUDA Ryosuke Exercise physiology, Pedagogy of physical education Professor(Additional Post) Assistant Professor SAWADA Mio Kanpo medicine, Women medical care
Keywords of Research
neurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection
Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.
Publications
Originals 0368B001 (H.Tada), M.Kawashiri, A.Nohara, A.Inazu, J.Kobayashi, H.Mabuchi, M.Yamagishi:Autosomal recessive hypercholesterolemia: A mild phenotype of familial hypercholesterolemia: Insight from the kinetic study using stable
isotope and animal studies, Journal of Atherosclerosis and Thrombosis, 22:1;1-9, 2015.
0368B002 (T.Shirakawa), K.Nakajima, S.Yatsuzuka, Y.Shimomura, J.Kobayashi, T.Machida, H.Sumino, M.Murakami:The role of circulating lipoprotein lipase and adiponectin on the particle size of remnant lipoproteins in patients with
diabetes mellitus and metabolic syndrome, Clinica Chimica Acta, 440:123-132, 2015.
0368B003 (H.Tada), MA.Kawashiri, M.Takata, K.Matunami, A.Imamura, M.Matuyama, H.Sawada, H.Nunoi, T.Konno, K.Hayashi, A.Nohara, A.Inazu, J.Kobayashi, H.Mabuchi, M.Yamagishi:Infantile cases of sitosterolaemia with novel mutations in the ABCG6 gene:Extreme hypercholesterolaemia is exacerbated by breastfeeding, JIMD Reports,
21:115-122, 2015.
0368B004 (T.Shirakawa), K.Nakajima, Y.Shimomura, J.Kobayashi, S.Kimber, H.Peter, T.Machida, H.Sumino, M.Murakami:Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride
lipase on remnant lipoprotein metabolism, Clinica Chimica Acta, 440:193-200, 2015.
0368B005 N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis and
Thrombosis, 22:10;1051-1060, 2015.
0368B006 (H.Tada), M.Kawashiri, H.Okada, R.Teramoto, T.Konno, T.Yoshimuta, K.Sakata, A.Nohara, A.Inazu, J.Kobayashi, H.Mabuchi, M.Yamagishi, K.Hayashi:Assessment of coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography, American Journal of Cardiology, 115:6;724-
729, 2015.
47 0368B007 J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.
0368B008 (H.Kakuda), J.Kobayashi, M.Kakuda, N.Takekoshi:Comparison of the long term effect of telmisartan/amlodipine versus telmisartan/hydorochlorothiazide on day-by-day variability of home blood pressure in Japanese
hypertensive subjects, Journal of Kanazawa Medical University, 40:2-3;154-160, 2015.
Reviews 0368C001 J.Kobayashi, K.Miyashita, K.Nakajima, H.Mabuchi:Hepatic Lipase:A comprehensive view of it's role on plasma lipid
and lipoprotein metabolism, Journal of Atherosclerosis and Thrombosis, 22:10;1001-1011, 2015.
0368C002 J.Kobayashi, H.Mabuchi:Lipoprotein lipase and aherosclerosis, The Annals of Clinical Biochemistry, 52:6;632-637,
2015.
Case Reports 0368D001 (M.Kawashiri), H.Tada, M.Hashimoto, M.Taniyama, T.Nakano, K.Nakajima, T.Inoue, M.Mori, C.Nakanishi, T.Konno, K.Hayashi, A.Nohara, A.Inazu, J.Koizumi, H.Ishihara, J.Kobayashi, T.Hirano, H.Mabuchi, M.Yamagishi:Extreme contrast of postprandial remnant-like particles formed in abetalipoproteinemia and
homozygous familial hypobetalipoproteinemia, JIMD Reports, 22:85-94, 2015.
0368D002 J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi:Effective treatment with Kampo medicines of
fibromyalgia that occurred after the mycoplasma infection, PAIN AND KAMPO MEDICINE, 25:129-133, 2015.
Short Communications 0368E001 (H.Kakuda), J.Kobayashi, M.Kakuda, J.Yamakawa, N.Takekoshi:The effect of anagliptin treatment on glucose metabolism and lipid metabolism, and oxidative stress in fasting and postprandial states using a test meal in
Japanese men with type 2 diabetes, Endocrine, 48:3;1005-1009, 2015.
Others 0368F001 J.Kobayashi:How does bezafibrate affect the plasma LDL cholesterol levels?, Journal of Atherosclerosis and
Thrombosis, 22:7;658-659, 2015.
0368F002 J.Yamakawa, J.Moriya, J.Kobayashi:Research of the influence of female on the visceral fat by aging :The
improvement by a kampo medicine, Journal of Society for Women's Health Science Research , 4:1;45-48, 2015.
48 0370 Department of Geriatric Medicine
Faculty
Title Name Field of Specialization Geriatrics, Hypertension, Calcium Metabolism, Dementia, Professor MORIMOTO Shigeto Osteoporosis Professor(Additional Post) NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis Professor(Additional Post) IWAI Kunimitsu Geriatrics, Circulation, Cell Biology, Cardiology Associate Professor OKURO Masashi Geriatrics, Circulation, Hypertension, Atherosclerosis Assistant Professor IRITANI Osamu Geriatrics, Circulation Assistant Professor MORITA Takuro Geriatrics, Circulation Assistant Professor YANO Hiroshi Geriatrics, Circulation Assistant Professor OKUNO Tazuo Geriatrics, Circulation Assistant Professor HIMENO Taro Geriatrics, Circulation
Keywords of Research
elderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension, nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale, mini-mental state examination, eicosapentaenoic acid, osteoporosis,
Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acute diseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and of elderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using culture of arterial cells.
Publications
Originals 0370B001 (N.Kawai), N.Sakai, M.Okuro, S.Karakawa, Y.Tsuneyoshi, N.Kawasaki, T.Takeda, M.Bannai, S.Nishino:The sleep- promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus,
Neuropsychopharmacology, 40:6;1405-1416, 2015.
0370B002 T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda, S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.
49 0380 Department of Pediatrics
Faculty
Title Name Field of Specialization Professor SAIKAWA Yutaka Pediatric hematology, Pediatric oncology NAKAMURA Associate Professor Pediatric cardiology Tsuneyuki Pediatric endocrinology, Pediatric metabolism, Inborn errors of Senior Assistant Professor ITO Masatsune metabolism Infectionus disease in children, Moleculer biology, Child neurology, Senior Assistant Professor SATO Hitoshi Inborn errors of metabolism Senior Assistant Professor OKADA Naoki Pediatric hematology, Pediatric oncology Senior Assistant Professor KOBAYASHI Azusa Neonatology Senior Assistant Professor NAKAMURA Toshimi Pediatric allergy, Pediatric immunology Senior Assistant Professor FUJIKI Takuma Pediatric Nephrology Assistant Professor AKITA Chisato Pediatric cardiology Assistant Professor OGURI Masato Pediatric cardiology. Assistant Professor KOH Giyo Connective tissue disease Assistant Professor IKENO Kanjyu Child neurology Assistant Professor KITTAKA Yuko Pediatric allergy, Pediatric endocrinology
Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism, leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood,
Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.
Publications
Originals 0380B001 (R.Takahiro), S.Nakamura, H.Kohno, N.Yoshimura, T.Nakamura, S.Ozawa, K.Hirono, F.Ichida, M.Taguchi :Contribution of CYP3A isoforms to dealkylation of PDE6 inhibitors: A comparison between sildenafil
N-demethylation and tadalafil demethylenation, Biological & pharmaceutical bulletin, 38:1;58-65, 2015.
Case Reports 0380D001 M.Matsumoto, Y.Tanaka, C.Tanaka, S.Nakagawa, Y.Yanaida, K.Nagata, T.Fujiki, Y.Iinuma:Four pediatric cases of ammonium acid urate crystal with nephrotic syndrome, The Japanese journal of medical technology, 64:5;541-547,
2015.
50
Short Communications 0380E001 (Y.Mitsui), T.Nakamura, K.Shimizu, N.Okamoto, S.Toki, Y.Kittaka, G.Ko, C.Akita, H.Sato, N.Okada, A.Kobayashi, T.Nakamura, Y.Saikawa:Practical use of the electronic stethoscope for the pediatric residents'
training program, Journal of Kanazawa Medical University, 40:201-204, 2015.
Others 0380F001 Y.Kittaka, N.Okamoto, S.Toki, G.Ko, M.Oguri, C.Akita, T.Nakamura, Y.Saikawa:Activation of the fibrinolytic
system during the initial stage in patients with Kawasaki disease, Progress in Medicine, 35:7;1112-1115, 2015.
Presentations at Conference
International Conference (Presentations) 0380I001 T.Nakamura, T.Nakamura, G.Ko, Y.Yamashita, C.Akita, Y.Saikawa:Over 5 Years Follow-up of Kawasaki Disease
with Atopic Bronchial Asthma, Eleventh International Kawasaki Disease Symposium, Honolulu, 2015.
0380I002 (Y.Shimizu), T.Nakamura, G.Ko, M.Oguri, C.Akita, Y.Saikawa:Relationship between Kawasaki Disease related- Angiopathy and Pressure Wave Reflection in the Arterial System, Eleventh International Kawasaki Disease
Symposium, Honolulu, 2015.
0380I003 T.Nakamura:Arterial dysfunction in pediatric patients with chronic illnesses, The 7th Joint Scientific Meeting
Between HUST-TMC and KMU, Wuhan, 2015.
51 0390 Department of Neuropsychiatry
Faculty
Title Name Field of Specialization Cognitive neurosciences, Neuropsychology, Neuroimaging, Professor KAWASAKI Yasuhiro Psychopharmacology, Neurophysiology Senior Assistant Professor WATANABE Kenichiro Neuropsychology, Neuropharmacology Senior Assistant Professor UEHARA Takashi Neuropharmacology Senior Assistant Professor KITAMOTO Fukumi Psychotherapy, Clinical Psychology Assistant Professor KOSEKI Yojyu Brain imaging Assistant Professor NITTA Yusuke Consultation liaison psychiatry Assistant Professor HASHIMOTO Reiko Psychotherapy, Clinical Psychology Assistant Professor KIHARA Hiroaki Brain imaging,，Schizophrenia Assistant Professor SHIMADA Takamitsu Brain imaging,，Schizophrenia
Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict, anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma, attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging
Outline of Research
1.Study on regional identification of brain language areas by functional MRI―application for surgical therapy of epilepsy 2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT 3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal experiments 4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia 5.Clinical study on psychiatric disturbance in epilepsy 6.Study on cognitive-behavioural therapy for obsessive compulsive disorder 7.Study on music therapy for dementia
Publications
Reviews 0390C001 T.Uehara, T.Sumiyoshi, M.Kurachi:T-817MA, a novel neurotrophic agent, as a new pharmacotherapy of
schizophenia, Japanese Journal of Biological Psychiatry, 26:3;154-160, 2015.
0390C002 T.Uehara, T.Sumiyoshi, M.Kurachi:New pharmacotherapy targeting cognitive dysfunction of schizophrenia via
modulation of GABA neuronal function, Current Neuropharmacology, 13:6;793-801, 2015.
52 Presentations at Conference
International Conference (Presentations) 0390I001 Y.Nagayama, A.Fukutsuka, K.Ikuno, R.Kaneda, Y.Kawasaki, M.Kitamura, Y.Minabe, T.Nagasawa, H.Nakade, M.Oe:Relationship between coercive measures and nursing interventions in university hospital psychiatric wards in
Japan, 17th Annual Conference of the International Society of Psychiatric-Mental Health Nurses, Seattle, 2015.
0390I002 Y.Matsuda, H.Kihara, K.Watanabe, R.Hashimoto, S.Takemoto, Y.Kawasaki:Support vector machine classification for patients with major depressive disorder and bipolar disorder using near-inflated spectroscopy., 12th World
Congress of Biological Psychiatry, Athens, 2015.
53 0400 Department of Radiology
Faculty
Title Name Field of Specialization Professor TONAMI Hisao Head and Neck Radiology, MRI Diagnosis Professor MATOBA Munetaka Interventional Radiology, Diagnostic Imaging、Radiation therapy Professor WATANABE Naoto Nuclear Medicine Assistant Professor OTA Kiyotaka Radiation Therapy，Nuclear Medicine (Additional Post) Assistant Professor KITADATE Masataka Interventional Radiology, Diagnostic Imaging Assistant Professor KONDO Tamaki Diagnostic Imaging Assistant Professor TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging (Additional Post) Assistant Professor TSUCHIYA Naoko Diagnostic Imaging Assistant Professor DOAI Mariko Diagnostic Imaging Assistant Professor TOYOTA Ichiro Diagnostic Imaging Assistant Professor OISO Kazumasa Diagnostic Imaging
Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery, brachitherapy, PEI, Sjogren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic stent, contrast medium,
Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy and Transarterial Embolization using MD-CT, MRI and MRS. 2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET. 3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy Planning System. 4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.
Publications
Originals 0400B001 Y.Sasagawa, O.Tachibana, M.Doai, H.Tonami, H.Iizuka:Median nerve conduction studies and wrist magnetic
resonance imaging in acromegalic patients with carpal tunnel syndrome, Pituitary, 18:5;695-700, 2015.
0400B002 N.Watanabe:Our study of radiotoxicity after Iodine-131 Therapy for thyroid cancer, Journal of Kanazawa Medical
University, 40:182-185, 2015.
0400B003 M.Matoba, H.Tuji, Y.Shimode, T.Kondo, K.Oota, H.Tonami:Lesion regression rate based on RECIST: prediction of treatment outcome in patients with head and neck cancer treated with chemoradiotherapy compared with FDG
PET-CT, Journal of Radiation Research, 56:3;553-560, 2015.
54 0400B004 K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda, M.Sagawa:Diffusion weighted imaging can distinguish benign from malignant mediastinal tumors and mass lesions:
comparison with positron emission tomography, Asian Pacific Journal of Cancer Prevention, 16:6469-6475, 2015.
0400B005 K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda, M.Sagawa:Diagnostic performance of diffusion-weighted imaging for multiple hilar and mediastinal lymph nodes with
FDG accumulation, Asian Pacific Journal of Cancer Prevention, 16:6401-6406, 2015.
Case Reports 0400D001 H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai, T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.
Presentations at Conference
International Conference (Presentations) 0400I001 M.Doai, I.Toyota, H.Tonami, Y.Sasagawa, O.Tachibana, T.Nojima:Utility of apparent diffusion coefficient value for distinguishing pituitary atypical adenomas from typical adenomas, European Congress of Radiology2015, Wien,
2015.
0400I002 H. Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, M.Furukawa, S.Kinuya, T.Miwa:Prognostic value of olfactory nerve assessment with olfacto-scintigraphy in patients with olfactory disorders, The 37th annual meeting of the
Association for Chemoreception Sciences, Bonita Sorings, 2015.
55 0410 Department of Cardiovascular Surgery
Faculty
Title Name Field of Specialization Professor AKITA Toshiaki Cardiovascular surgery Professor KAWAHIRA Yoichi Cardiovascular surgery Professor SHIKATA Hiroo Vascular surgery Associate Professor MORIOKA Koichi Cardiovascular surgery Senior Assistant Professor KOBATA Takashi Vascular surgery Senior Assistant Professor NOGUCHI Yasuhisa Vascular surgery Senior Assistant Professor MIZUNO Fumito Cardiovascular surgery Assistant Professor TANAKA Hirokazu Cardiovascular surgery, Vascular surgery Assistant Professor TSUCHIYA Hirokazu Cardiovascular surgery, Vascular surgery
Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery for congestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer,
Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development of cardioplegia specific for neonate cardiac surgery. 2.Development of patient-specific cardiac supporting net for dilated heart failure patients 3.Endovascular stent-grafting for aortic aneurysm
Publications
Case Reports 0410D001 T.Kobata, H.Shikata, Y.Noguchi:Entry closure of stanford type B chronic aortic dissection using an elephant trunk
type stent graft, Japanese Journal of Endovascular Intervention , 16:1;27-30, 2015.
Presentations at Conference
International Conference (Presentations) 0410I001 T.Kobata:A case of TEVAR for false aneurysm in the remote period by the stent graftodevice, The 16th Congress
of Asian society for Vascular Surgery, Bangkok, 2015.
56 0415 Department of Thoracic Surgery
Faculty
Title Name Field of Specialization thoracic surgery, lung cancer, video assisted thoracoscopic surgery, Professor SAGAWA Motoyasu epidemiology of mass screening thoracic surgery, video assisted thoracoscopic surgery, lung cancer, Professor USUDA Katsuo mediastinal tumor, early lung cancer, interventional bronchology, clinical cytology Associate Professor MAEDA Sumiko thoracsu surgery, lung cancer Assistant Professor TANAKA Makoto thoracic surgery, lung cancer, pulmonary circulation Assistant Professor MACHIDA Yuichiro thoracic surgery, lung cancer, pulmonary circulation Assistant Professor MOTONO Nozomu thoracic surgery, lung cancer, pulmonary circulation
Keywords of Research
thoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy, lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax
Outline of Research
Lung tumor 1. Screening test for lung cancer 2. Virtual bronchoscopy 3. Ion channel on cancer cells 4. Chemotherapy 5. Surgical treatment 6. Video assisted thoracoscopic surgery (VATS)
Mediastinal and pleural tumors 1. FDG-PET for mediastinal tumor 2. VATS 3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury 1. Perioperative lung injury 2. Beta-agonist and antagonist therapy 3. Ischemia reperfusion lung injury 4. Aspiration lung injury 5. RAGE mice
New instruments 1. Bronchoscopy 2. Thoracoscopy
57 Publications
Originals 0415B001 M.Sagawa, T.Kobayashi, C.Uotani, Y.Kibe, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda:A survey about further work-up for cases with positive sputum cytology during lung cancer mass screening in Ishikawa Prefecture, Japan: a retrospective analysis about quality assurance of lung cancer screening, Japanese Journal of Clinical
Oncology, 45:3;297-302, 2015.
0415B002 (K.Ichikawa), T.Kobayashi, M.Sagawa, A.Katagiri, Y.Uno, R.Nishioka, J.Matsuyama:A phantom study investigating the relationship between ground-glass opacity visibility and physical detectability index in low-dose chest
computed tomography, Journal of Applied Clinical Medical Physics, 16:4;202-215, 2015.
0415B003 K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda, M.Sagawa:Diffusion weighted imaging can distinguish benign from malignant mediastinal tumors and mass lesions: comparison with positron emission tomography, Asian Pacific Journal of Cancer Prevention, 16:6469-6475, 2015. 0415B004 K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda, M.Sagawa:Diagnostic performance of diffusion-weighted imaging for multiple hilar and mediastinal lymph nodes with
FDG accumulation, Asian Pacific Journal of Cancer Prevention, 16:6401-6406, 2015.
Reviews 0415C001 (H.Tanaka), T.Hiura, K.Nishii, M.Sato, K.Oketani, T.Kobayashi, H.Kobayashi, S.Takahashi, I.Sato, K.Eguchi, T.Sobue, T.Nakayama, M.Sagawa:A randomized controlled trial on the efficacy of thoracic CT screening for lung cancer in non-smokers and smokers of<30 pack-years aged 50-64 years to provide the new evidence from japan,
The Journal of the Japanese Society of CT Screening, 22:2;3-8, 2015.
0415C002 M.Sagawa, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda:Overdiagnosis in the CT screening for lung
cancer, The Journal of the Japanese Society of CT Screening, 22:2;9-14, 2015.
0415C003 M.Sagawa, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda:Revision of the criteria for selecting subjects for
sputumj cytology of lung cancer screening in Japan, Journal of Kanazawa Medical University, 40:2・3;44-46, 2015.
Case Reports 0415D001 H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai, T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.
0415D002 Y.Machida, M.Tanaka, N.Motono, S.Maeda, K.Usuda, M.Sagawa:Successful treatment of bronchial fistula after pulmonary lobectomy by endobronchial embolization using an endobronchial watanabe spigot, Hindawi Publishing
corporation , 425694:1-3, 2015.
0415D003 Y.Machida, M.Tanaka, N.Motono, S.Maeda, K.Usuda, M.Sagawa:Malignant fibrous histiocytoma accompanying
hemorrhage in the pleural cavity, Journal of Case Reports and Studies, 2:4;1-3, 2015.
0415D004 M.Sagawa, Y.Machida, M.Tanaka, N.Motono, S.Maeda, T.Sakuma, K.Usuda:Left pulmonary agenesis showing extraordinary chest X-ray findings, American Journal of Respiratory and Critical Care Medicine, 191:9;1083, 2015.
Presentations at Conference
International Conference (Synposium) 0415H001 M.Sagawa:Identify the kevel of implementation and planning for CT screening camprehensive programs across the
globe: Japan, IASLC Strategic screening advisory committee(SSAC)CTScreening work shop, Denver, 2015.
0415H002 M.Sagawa, The JECS Study Group:Screening in Japan-The JECS Stedy, 15th world canference on lung cancer,
Denver, 2015.
58 0420 Department of General and Digestive Surgery
Faculty
Title Name Field of Specialization Professor KOSAKA Takeo Surgical treatment of gastric cancer Professor UEDA Nobuhiko Surgical treatment of hepatobiliary and pancreatic disease Professor NOGUCHI Masakuni Surgery of breast cancer Associate Professor OMOTE Kazuhiko Surgical treatment of gastric cancer Associate Professor KINAMI Shinichi Surgical treatment of gastric cancer Associate Professor NAKANO Yasuharu Surgery of breast cancer Senior Assistant Professor FUJITA Hideto Surgical treatment of gastric cancer, Senior Assistant Professor FUNAKI Hiroshi Surgical treatment of gastric cancer Senior Assistant Professor NOGUCHI Miki Surgery of breast cancer Assistant Professor ONISHI Toshio Surgery of Digestive Diseases Assistant Professor ONO Yukako Surgery of Digestive Diseases, Surgical treatment of breast cancer Assistant Professor KAIDA Daisuke Surgery of Digestive Diseases Assistant Professor TOMITA Yasuto Surgery of Digestive Diseases Assistant Professor MORIOKA Emi Surgery of Digestive Diseases Assistant Professor FUJITA Jun Surgery of Digestive Diseases
Keywords of Research
pancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of the laparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization, functional preserving operation, education and training, engineering and robotics,
Outline of Research
1 Advanced surgery for gastrointrestinal cancer 2 Biomarker of gastrointestinal cancer 3 Gastrointestinal reconstruction and its evaluation 4 Function saving cancer surgery 5 Minimally invasive cancer treatment 6 Tailored cancer chemotherapy
Publications
Originals 0420B001 (K.Nakada), M.Ikeda, M.Takahashi, S.Kinami, M.Yoshida, Y.Uenosono, Y.Kawashima, A.Oshio, Y.Suzukamo, M.Terashima, Y.Kodera:Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in
postgastrectomy patients, Gastric Cancer, 18:1;147-158, 2015.
59 0420B002 (T.Namikawa), N.Hiki, S.Kinami, H.Okabe, T.Urushihara, H.Kawahira, N.Fukushima, Y.Kodera, T.Yumiba, A.Oshio, K.Nakada:Factors that minimize postgastrectomy symptoms following pylorus-preserving gastrectomy:
assessment using a newly developed scale (PGSAS-45), Gastric Cancer, 18:397-406, 2015.
0420B003 T.Itoh, H.Kitakata, S.Kinami, K.Kawaura, K.Hamada, S.Azukisawa, R.Itoh, K.Omote, T.Kosaka, M.A.Fujino:New treatment strategy for submucosa-infiltrating gastric cancer without sentinel node metastasis: A pilot study of laparoscopy-assisted endoscopic full-thickness resection in an IN VIVO porcine model., ENDOSCOPIC FORUM
for digestive disease, 31:1;17-26, 2015.
0420B004 H.Funaki, Y.Fujii, J.Fujita, E.Morioka, D.Kaida, T.Ohnishi, Y.Tomita, M.Noguchi, H.Fujita, S.Kinami, Y.Nakano, N.Ueda, T.Kosaka:Clinical analysis of esophageal bypass surgery with nutritional assessment in patients with
unresectable esophageal cancer, Japanese Journal of Cancer and Chemotherapy, 42:12;1543-1546, 2015.
0420B005 (Y.Yoshida), K.Hirata, H.Matsuoka, S.Iwamoto, M.Kotaka, H.Fujita, N.Aisu, S.Hoshino, T.Kosaka, K.Maeda, F.Kiyomi, Y.Yamashita:A single-arm phase Ⅱ validation study of preventing oxaliplatin-induced hyperseｎsitivity
reactions by dexamethasone: the AVOID trial, Drug Design, Development and Therapy, 9:6067-6073, 2015.
Reviews 0420C001 M.Noguchi, S.Miura, E.Morioka, Y.Ohno, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka:Is axillary reverse mapping
feasible in breast cancer patients?, European Journal of Surgical Oncology, 41:442-449, 2015.
0420C002 (T.Fujimura), S.Fushida, T.Tsukada, J.Kinoshita, K.Oyama, T.Miyashita, H.Takamura, S.Kinami, T.Ohta:A new
stage of sentiel node navigation surgery in early gastric cancer, Gastric Cancer, 18:210-217, 2015.
0420C003 Y.Ohno, M.Noguchi, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka, N.Kurose, H.Minato:Tangential frozen section analysis for the surgical margins in breast-conserving surgery, American Journal of Breast Cancer Research ,
2:1;9-20, 2015.
0420C004 S.Kinami, T.Kosaka:Is local resection of the stomach suitable as curative surgery for gastric cancer?, Journal of
Kanazawa Medical University, 40:2・3;145-148, 2015.
0420C005 M.Noguchi, Y.Nakano, M.Noguchi, Y.Ohno, E.Morioka, S.Miura:Oncoplastic breast conserving surgery: Volume replacement replacement vs. volume displacement, Journal of Kanazawa Medical University, 40:2・3;37-43, 2015.
Case Reports 0420D001 T.Ohnishi, N.Ueda, D.Kaida, H.Fujita, S.Kinami, T.Kosaka:A case of xanthogranulomatous cholecystitis that was
able to observe an image change with time, 29:4;815-823, 2015.
0420D002 N.Ueda, S.Miura, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, H.Fujita, S.Kinami, Y.Nakano, T.Kosaka:A case of gastric and pancreatic cancer resected with curative intent while preserving organ
function , Japanese Journal of Cancer and Chemotherapy, 42:12;2343-2345, 2015.
0420D003 Y.Tomita, Y.Fujii, S.Miura, J.Fujita, E.Morioka, D.Kaida, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, H.Fujita, S.Kinami, Y.Nakano, N.Ueda, T.Kosaka, N.Sakata:A successful case of treatment of colonic metastsis and peritoneal recurrence of type 4 gastric cancer by using colectomy and chemotherapy, Japanese Journal of Cancer
and Chemotherapy, 42:12;1591-1593, 2015.
0420D004 N.Ueda, T.Ohnishi, D.Kaida, H.Fujita, S.Kinami, T.Kosaka, E.Kinoshita, N.Kurose:A case of primary liver
adenosquamous carcinoma with central necrosis, 29:5;905-912, 2015.
Others
0420F001 M.Noguchi:Z-11 trial and rethinking axillary reverse mapping, Breast Cancer, 22:99-100, 2015.
60 Presentations at Conference
International Conference (Presentations) 0420I001 Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th Annual Asian Oncology Summit, 12th Annual Conference of the OOTR and the Kyoto Breast Cancer Consensus
Conference 2016, Kyoto, 2015.
61 0430 Department of Orthopaedic Surgery
Faculty
Title Name Field of Specialization Professor MATSUMOTO Tadami Hip surgery Professor KAWAHARA Norio Spinal surgery Professor KANEUJI Ayumi Hip and Knee surgery, Sports medicine Associate Professor SUGIMORI Tanzo Hip and Knee surgery, Sports medicine Associate Professor ICHISEKI Toru Hip surgery, Shoulder surgery Senior Assistant Professor FUKUI Kiyokazu Hip surgery Senior Assistant Professor HIROMURA Kentaro Trauma KAWAGUCHI Senior Assistant Professor Spinal surgery Masahito Assistant Professor HATANO Eijyu Spinal surgery Assistant Professor TACHI Yoshiyuki Spinal surgery Assistant Professor TAKAHASHI Eiji Hip surgery Assistant Professor ORITA Yugo Spinal surgery, orthopaedic surgery Assistant Professor TAGUCHI Keita orthopaedic surgery Assistant Professor UEDA Shusuke Hip surgery Assistant Professor SHIMIZU Yoshiaki Spinal surgery Assistant Professor TSUDA Ryoji Hip surgery
Keywords of Research
herniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor, coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft, patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbar interbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture, humeral shaft fracture, osteonecrosis, spinal cord injury
Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we are researching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced osteonecrosis of femoral head to prevent the occurrence of the disease. Furthermore, regarding digestion of chondroitin sulfate proteoglycans(CSPG) that accumulate at injured site after spinal cord injury, we confirmed that Hyaluronidase-4 expressed at injured spinal cord. It have been thought that Hyaluronidase-4 is a digestive enzyme of CSPG . In future, we will clarify the mechanism.
62 Publications
Originals 0430B001 Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.
0430B002 K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, Y.Hiejima:Clinical assessment after total hip arthroplasty using the Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire, Journal of
Orthopaedics, 12:sup.1;S31-S36, 2015.
0430B003 K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto:Does rotational acetabular osteotomy affect subsequent
total hip arthroplasty?, Archives of Orthopaedic and Trauma Surgery, 135:3;407-415, 2015.
0430B004 (Y.Okamoto), H.Murakami, S.Demura, S.Kato, K.Yoshioka, H.Hayashi, J.Sakamoto, N.Kawahara, H.Tsuchiya:The effect of kyphotic deformity because of vertebral fracture - a finite element analysis of a 10 and 21 degree wedge- shaped vertebral fracture model -, The spine journal : official journal of the North American Spine Society,
15:4;713-720, 2015.
0430B005 K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto:Bone remodeling after a mean of 10 years in diaphyseal cortical defects repaired with femoral revision using bypass fixation of extensively porous-coated stems with high stiffness, European Journal of Orthopaedic Surgery & Traumatology : OrthopéDie Traumatologie, 25:4;741-747,
2015.
0430B006 A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:Rotational acetabular osteotomy for osteoarthritis with acetabular dysplasia: Conversion rate to total hip arthroplasty within twenty years and osteoarthritis progression after a minimum of twenty years, The Journal of bone and joint surgery. American
volume, 97:9;726-732, 2015.
0430B007 (CL.Goldstein), PP.Varga, ZL.Gokaslan, S.Boriani, A.Luzzati, L.Rhines, CG.Fisher, D.Chou, RP.Williams, MB.Dekutoski, NA.Quraishi, C.Bettegowda, N.Kawahara, MG.Fehlings:Spinal hemangiomas: results of surgical
management for local recurrence and mortality in a multicenter study, Spine-Phila Pa 1976, 40:9;656-664, 2015.
0430B008 (H.Hayashi), H.Murakami, S.Demura, S.Kato, N.Kawahara, H.Tsuchiya:Outcome of posterior lumbar interbody
fusion for L4-L5 degenerative spondylolisthesis, Indian journal of orthopaedics, 49:3;284-288, 2015.
0430B009 S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015.
0430B010 S.Simizu:Inhibitory effect of hyaluronidase-4 in a rat spinal cord hemisection model, Journal of Kanazawa Medical
University, 40:1;9-16, 2015.
0430B011 T.Ichiseki, S.Ueda, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto:Age-related changes of mitochondrial transcription factor a expression in rotator cuff degeneration, American Journal of Translational Research,
7:10;2099-2104, 2015.
0430B012 (D.Choi), Z.Fox, T.Albert, M.Arts, L.Balabaud, C.Bunger, JM.Buchowski, MH.Coppes, B.Depreitere, MG.Fehlings, J.Harrop, N.Kawahara, JA.Martin-Benlloch, EM.Massicotte, C.Mazel, FC.Oner, W.Peul, N.Quraishi, Y.Tokuhashi, K.Tomita, JJ.Verlaan, M.Wang, HA.Crockard:Prediction of quality of life and survival after surgery for symptomatic spinal metastases: a multicenter cohort study to determine suitability for surgical
treatment, Neurosurgery, 77:5;698-708, 2015.
Case Reports 0430D001 K.Fukui, A.Kaneuji, M.Fukushima, T.Matsumoto:Early MRI and intraoperative findings in rapidly destructive
osteoarthritis of the hip: a case report, International Journal of Surgery Case Reports, 8:13-17, 2015.
0430D002 T.Ichiseki, S.Ueda, T.Matsumoto:Rare coexistence of gouty and septic arthritis after arthroscopic rotator cuff
repair: a case report, International Journal of Clinical and Experimental Medicine, 8:3;4718-4720, 2015.
63 0430D003 K.Fukui, A.Kaneuji, T.Matsumoto:Occult fracture of the femoral neck associated with extensive osteonecrosis of
the femoral head: a case report, International Journal of Surgery Case Reports, 14:136-140, 2015.
0430D004 (K.Yoshioka), H.Murakami, S.Demura, S.Kato, N.Kawahara, K.Tomita, H.Tsuchiya:Spinal metastasis from subcutaneous sacrococcygeal ependymoma: a case report with long-term follow up, The Surgery Journal, 1:1;e50-
e53, 2015.
Presentations at Conference
International Conference (Key Note Lecture) 0430G001 N.Kawahara: Spinal cord blood flow after ligation of multiple segmental arteries. Animal research and clinical
experience, 4th Bologna-Budapest Spine: AOSpine symposium, Bologna, 2015.
0430G002 N.Kawahara: Infection after surgical treatment of spine tumor, 4th Bologna-Budapest Spine Meeting on Tumor &
Osteoporosis, Bologna, 2015.
0430G003 N.Kawahara: Preoperative embolization of multiple segments for reduction of intraoperative bleeding in spinal
tumor surgery, 4th Bologna-Budapest Spine Meeting on Tumor & Osteoporosis, Bologna, 2015.
International Conference (Synposium) 0430H001 A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:Cementless anatomic total hip femoral component with circumferential porous coating for hips with developmental dysplasia: a minimum ten-years follow-
up period, 2015 ICJR Hip JAPAN (International Congress for Joint Reconstruction), Osaka, 2015.
International Conference (Presentations) 0430I001 K.Fukui, A.Kaneuji, T.Matsumoto, K.Shintani:Squeaking and microcracks in a Delta-delta ceramic coupling: pin-
on-disc study, ORS 2015 Annual Meeting (Orthopaedic Research Society), Las Vegas, 2015.
0430I002 K.Fukui, K.Briggs, C.Trindade, M.Philippon:Patient-centered outcomes in borderline dysplastic patients with femoroacetabular impingement who underwent labral repair and treatment of impingement, 10th Biennial Congress of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS 2015), Lyon,
2015.
0430I003 A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:A minimum ten-year result for cementless acetabular components fixed without press-fit in developmental dysplasia of the hip, ICJR 2015 2nd Annual Pan
Pacific Orthopaedic Congress, Kona, 2015.
0430I004 E.Takahashi, A.Kaneuji, K.Hirosaki, M.Takano, R.Tsuda, T.Matsumoto:Relationship between bone cement thickness and cement creep: an experimental study using collarless polished tapered stems, ICJR 2015 2nd Annual
Pan Pacific Orthopaedic Congress, Kona, 2015.
0430I005 K.Fukui, A.Kaneuji, T.Matsumoto:Arthroscopic correction for concomitant cam impingement in a patient with idiopathic osteonecrosis of the femoral head, ISHA Annual Scientific Meeting 2015 (International Society for Hip
Arthroscopy), Cambridge, 2015.
0430I006 A.Kaneuji, E.Takahashi, R.Tsuda, T.Matsumoto, L.Kerboull:Biomechanical behavior of stem and cement in a collarless polished tapered stem and a french stem: an experimental study using original biomechanical instrument,
ISTA 2015 (International Society for Technology in Arthroplasty), Vienna, 2015.
0430I007 E.Takahashi, A.Kaneuji, K.Hirosaki, M.Takano, R.Tsuda, T.Matsumoto:Difference of stem subsidence and cement behavior in the various thickness of bone cement: an experimental study using a collarless polished tapered stems,
ISTA 2015 (International Society for Technology in Arthroplasty), Vienna, 2015.
64 0440 Department of Neurosurgery
Faculty
Title Name Field of Specialization Professor IIZUKA Hideaki spinal disease, brain tumor, peripheral nerve disease Professor TAKADA Hisashi cerebrovascular disease，endovascular therapy Professor AKAI Takuya brain tumor, pediatric neurosurgical disease Senior Assistant Professor SIRAGA Syunsuke cerebrovascular disease Assistant Professor SASAGAWA Yasuo brain tumor Professor TACHIBANA Osamu brain tumor, hypothalamic and pituitary tumor Senior Assistant Professor OKAMOTO Kazuya brain tumor, stereotactic radiosurgery Assistant Professor TSUKADA Tsuyoshi general neurosurgery，neuroembryology Assistant Professor TORIGOE Keiichiro general neurosurgery
Keywords of Research
brain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm, arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery, spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia, spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral ischemia
Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, the researchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies. 1. Brain tumor 1) development of tumor differentiation induction therapy for malignant gliomas 2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study) 3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classification and protein expression study) 4) radiological diagnosis of cystic pituitary tumors 5) disclose the pathogenesis of secondary hypophysitis 2. Spine and spinal cord disease 1) disclose the cord degeneration mechanism by spinal cord compression model 2) long term treatment results and affecting factors in spinal surgery 3. Cerebrovascular disease 1) disclose the molecular biological mechanism for acquisition of cerebral ischemia 4. Head injury 1) operation methods and recurrence in chronic subdural hematoma 5. Congenital anomaly 1) treatment of hydrocephalus in fetus model 2) disclose the responsible gene and surgical treatment for craniosynostosis
65 Publications
Originals 0440B001 Y.Sasagawa, O.Tachibana, M.Doai, H.Tonami, H.Iizuka:Median nerve conduction studies and wrist magnetic
resonance imaging in acromegalic patients with carpal tunnel syndrome, Pituitary, 18:5;695-700, 2015.
0440B002 Y.Sasagawa, T.Akai, O.Tachibana, H.Iizuka:Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse
large B-cell lymphoma of the central nervous system, Journal of neuro-oncology, 121:1;177-183, 2015.
0440B003 T.Tsukada, E.Simamura, H.Shimada, T.Arai, N.Higashi, T.Akai T, H.Iizuka, T.Hatta:The suppression of maternal- fetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in
mice, PLoS One, 10:6;e0129011, 2015.
0440B004 S.Shiraga, T.Akai, H.Takata, K.Okamoto, H.Iizuka:Investigation into the treatment outcome and problems of neck
clipping and coil embolization for ruptured cerebral aneurysms, Japanese Journal of Stroke, 37:1;1-6, 2015.
0440B005 K.Okamoto:Fractionated stereotactic radiotherapy for residual nonfunctioning pituitary adenoma, Stereotactic
Radiotherapy, 19:9-14, 2015.
0440B006 M.Yamashita, T.Akai, M.Kishibe, K.Shimada:One-piece bone flap osteotomy using thread wire saw for fronto- orbital advancement with distraction osteogenesis in craniosynostosis, Child's Nervous System, 31:2;279-283,
2015.
Reviews 0440C001 O.Tachibana:Rathke cleft cyst: review of pathology, imaging, and surgical outcome, Progress in Neuro-Oncology,
22:2;12-21, 2015.
Case Reports 0440D001 Y.Hayashi, M.Oishi, D.Kita, T.Watanabe, O.Tachibana, J.Hamada:Pure ｌymphocytic infundibuloneurohypophysitis caused by the rupture of rathke's cleft cyst: Report of 3 cases and review of the literature, Turkish Neurosurgery,
25:2;332-336, 2015.
0440D002 Y.Sasagawa, O.Tachibana, A.Nakagawa, D.Koya, H.Iizuka:Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma, Journal of Clinical Neuroscience,
22:3;601-603, 2015.
0440D003 T.Akai, K.Torigoe, M.Fukushima, H.Iizuka, Y.Hayashi:De novo aneurysm formation following gamma knife surgery
for arteriovenous malformation: A case report, Journal of neurological surgery reports, 76:1; e105-e108, 2015.
0440D004 S.Nakada, H.Minato, T.Takegami, N.Kurose, H.Ikeda, M.Kobayashi, Y.Sasagawa, T.Akai, T.Kato, N.Yamamoto, T.Nojima:NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma
with late distant metastases, Brain Tumor Pathology, 32:4;268-274, 2015.
0440D005 S.Shiraga, T.Akai, H.Takata, H.Iizuka:Possible cerebral infarction due to multiple segmental cerebral vasospasms
after carotid artery stenting: A case report, No Shinkei Geka, 43:12;1081-1089, 2015.
Presentations at Conference
International Conference (Presentations) 0440I001 M.Doai, I.Toyota, H.Tonami, Y.Sasagawa, O.Tachibana, T.Nojima:Utility of apparent diffusion coefficient value for distinguishing pituitary atypical adenomas from typical adenomas, European Congress of Radiology2015, Wien,
2015.
0440I002 T.Akai:Troubleshooting distraction osteogenesis for craniosynostosis, The 27th Annual Meeting of KSPN & 2015
JSPN-KSPN Joint Meeting, Soul, 2015.
66 0440I003 K.Okamoto, H.Iizuka, M.Futayama, K.Higashi:Clinical condition and frequency of delirium in head trauma patients
at neuro-intensive care unit, International Association of Risk Management in Medicine, Wien, 2015.
0440I004 T.Akai:One-piece bone flap osteotomy using thread wire saw for fronto-orbital advancement in craniosynostosis,
International society of craniofacial surgery, Chiba, 2015.
67 0450 Department of Plastic and Reconstructive Surgery
Faculty
Title Name Field of Specialization Professor KAWAKAMI Shigehiko Plastic and Reconstructive Surgery Associate Professor SHIMADA Kenichi Plastic and Reconstructive Surgery YAMASHITA Senior Assistant Professor Plastic and Reconstructive Surgery Masanobu Senior Assistant Professor KISHIBE Miyuki Plastic and Reconstructive Surgery Assistant Professor YAMAMOTO Yasunori Plastic and Reconstructive Surgery Assistant Professor KOMURO Akito Plastic and Reconstructive Surgery Assistant Professor KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery Assistant Professor KANEKO Takayoshi Plastic and Reconstructive Surgery Assistant Professor KOIZUMI Naoko Plastic and Reconstructive Surgery Assistant Professor SUGISHITA Kazuyuki Plastic and Reconstructive Surgery Assistant Professor DAIZO Haruhisa Plastic and Reconstructive Surgery Assistant Professor TAGUCHI Hisao Plastic and Reconstructive Surgery Assistant Professor DOI Yujin Plastic and Reconstructive Surgery Assistant Professor YAMASHITA Akiko Plastic and Reconstructive Surgery Assistant Professor NISHIBU Yasuhiro Plastic and Reconstructive Surgery Assistant Professor HIMI Yuji Plastic and Reconstructive Surgery Assistant Professor MIYANAGA Toru Plastic and Reconstructive Surgery Assistant Professor YAGISHITA Mikio Plastic and Reconstructive Surgery
Keywords of Research
fibroblast, FGF receptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocyte, wound healing, craniofacial surgery, zygoma, cleft lip, cleft palate, microtia, tissue expansion, crainofacial cleft, front-orbital advancement, microsurgery, free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in congenital anomaly
Outline of Research
1) Wound healing Promoting effects of wound dressings or drugs in wound healing process are studied clinicaly. 2) Tissue engineering Regeneration of the skin and subcutaneous tissue using artificial materials are studied clinicaly and experimentally 3) Cranio-maxillo-facial surgery New operative procedures in cranio-maxillo-facial fields are attempted to develope.
68 Publications
Originals 0450B001 A.Kumagai, M.Heinai, Y.Matsui, C.Konya, K.Shimada, S.Kawakami, J.Sugama:Effectiveness of highly resilient urethane foam mattresses in pressure ulcerprevention for special operative positions, Japanese journal of pressure
ulcer, 17:1;1-9, 2015.
0450B002 M.Yamashita, T.Akai, M.Kishibe, K.Shimada:One-piece bone flap osteotomy using thread wire saw for fronto- orbital advancement with distraction osteogenesis in craniosynostosis, Child's Nervous System, 31:2;279-283,
2015.
0450B003 M.Yamashita, H.Daizo, A.Yamashita, M.Kishibe, K.Shimada:Correction of late posttraumatic enophthalmos using
an antral balloon, The Journal of Craniofacial Surgery, 26:4;1365-1369, 2015.
Reviews
0450C001 M.Yamashita:Rhinoplasty with autogenous cartilage grafts, Japanese journal of plastic surgery, 58:3;235-244, 2015.
0450C002 K.Shimada:Novel use of dermal substitute combined with negative pressure wound therapy, Japanese journal of
plastic surgery, 58:12;1333-1342, 2015.
Case Reports 0450D001 M.Yagishita, Y.Haseda, A.Sakagami, T.Takemura:A case of semi-specific myiasis with neurofibromatosis type 1,
Journal of Japan Society of Plastic and Reconstructive Surgery, 35:210-214, 2015.
Presentations at Conference
International Conference (Presentations) 0450I001 A.Sakagami, M.Yamashita, H.Daizo, A.Yamashita, M.Kishibe, K.Shimada, S.Kawakami:Correction of Late Posttraumatic Enophthalmos Using an Antral Balloon, The 16th Congress of International Society of Craniofcial
Surgery, 2015, Maihama, 2015.
0450I002 A.Yamashita, M.Yamashita, K.Shimada, S.Kawakami:Three-Dimensional Computed Tomography Venography as a Guide for Cranioplasty in Parietal Cephalocele, The 16th Congress of International Society of Craniofcial Surgery,
2015, Maihama, 2015.
0450I003 M.Yamashita, A.Yamashita, M.Kishibe, K.Shimada, S.Kawakami:Incidence of lower eyelid complications after a ransconjunctival approach: Influence of repeated incisions, The 16th Congress of International Society of
Craniofacial Surgery, Maihama, 2015.
69 0460 Department of Pediatric Surgery
Faculty
Title Name Field of Specialization Professor KOHNO Miyuki Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy Professor IKAWA Hiromichi Pediatric surgery, Defecatory function, Liver transplantation Senior Assistant Professor YASUI Yoshitomo Pediatric surgery Assistant Professor KUWAHARA Tsuyoshi Pediatric surgery TAKAHASHI Assistant Professor Pediatric surgery Sadayoshi Assistant Professor SATOMI Miwa Pediatric surgery Assistant Professor YOSHIZAKI Hisayoshi Pediatric surgery
Keywords of Research
inguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriary atresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastro- esophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor, pediatric urology, phimosis, intestinal stoma,
Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia. The importance of rectal branch to induce high amplitude propagated colonic contraction. Clinical study of pediatric endoscopic surgery. Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.
Publications
Originals 0460B001 H.Yoshizaki, S.Okuda:Large-scale analysis of evolutionary histories of phosphorylation motifs in the human
genome, GigaScience, 4:21;1-6, 2015.
0460B002 (M.Yagi), M.Kohno, K.Asagiri, T.Ikeda, T.Okada, S.Kanada, S.Kawashima, Y.Goto, S.Takano, M.Yasufuku, M.Wada:Twenty-year trends in neonatal surgery based on a nationwide Japanese surveillance Program, Pediatric
Surgery International, 31:955-962, 2015.
0460B003 H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa:Regulation of Ripply1 expression in MDCK organoids,
Biochemical and Biophysical Research Communications, 468:1-2;337-342, 2015.
70 Presentations at Conference
International Conference (Presentations) 0460I001 H.Takada, H.Yoshizaki, E.Kiyokawa:In vivo imaging using a two-photon microscope in the mouse intestine, International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular
Activities, Kyoto, 2015.
0460I002 X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.
71 0470 Department of Ophthalmology
Faculty
Title Name Field of Specialization Professor SASAKI Hiroshi cataract, epidemiology, uveitis, electromagnetic ocular injury Professor KUBO Eri cataract, oxidative stress and eye disease, diabetic eye complication ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca, Professor KITAGAWA Kazuko lacrimal fluid, proteomics cataract, ophthalmological optics, electromagnetic ocular injury, Professor(Additional Post) KOJIMA Masami epidemiolgy Associate Professor FUKUDA Masamichi ocular pharmacdogy, intraocular, penetration Senior Assistant Professor KAWAKAMI Yutaka cataract Assistant Professor ARIMOTO Atsushi macular degeneration Assistant Professor OSADA Hiromi cataract, ophthalmology, macular degeneration Assistant Professor SHIBATA Shinsuke cataract, ophthalmology, oxidative stress and eye disease Assistant Professor SHIBATA Naoko cataract, ophthalmology, oxidative stress and eye disease Assistant Professor TAKAHASHI Yoriko cataract Assistant Professor HATSUSAKA Natsuko ophthalmological optics, epidemiology Assistant Professor FUJITA Nobuyuki uveitis
Keywords of Research
proteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UV- dosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis, intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional image, V-E, intraocular lens(IOL), cell culture
Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places (Ishikawa and Kagoshima, Japan, Singapore, Iceland, China and Tanzania). These studies have included prevalence, incidence and risk factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked on image analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visual performance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animal models and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases is also underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method for measuring corneal damage in vivo are all being investigated.
72 Publications
Originals 0470B001 M.Fukuda, H.Sasaki:The transcorneal penetration of commercial ophthalmic formulations containing timolol
maleate in rabbit eyes, Journal of Ocular Pharmacology and Therapeutics, 31:1;57-60, 2015.
0470B002 (H.Maeda), T.Takata, N.Fujii, H.Sakaue, S.Nirasawa, S.Takahashi, H.Sasaki, N.Fujii:Rapid survey of four asp isomers in disease-related proteins by LC-MS combined with commercial enzymes, Analytical Chemistry, 87:561-
568, 2015.
0470B003 M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki: Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40 GHz),
Journal of Infrared Millimeter and Terahertz Waves, 36:4;390-399, 2015.
0470B004 S.Enta, N.Hatsusaka, Y.Sakamoto, N.Mita, M.Takahashi, H.Osada, E.Kubo, H.Sasaki:Visual acuity and contrast visual acuity predicted from cataract type, The Journal of the Japanese Society for Cataract Research, 27:68-73,
2015.
0470B005 (K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto:Dielectric property measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, Physics in Medicine and Biology,
60:6273-6288, 2015.
0470B006 M.Fukuda, H.Sasak:Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing,
Journal of Ocular Pharmacology and Therapeutics, 31:9;536-540, 2015.
0470B007 Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki:Optical simulation for
subsurface nanoglistening, Journal of Cataract and Refractive Surgery, 41:193-198, 2015.
Reviews 0470C001 (K.Minami), K.Miyata, N.Nagai, H.Sasaki:Use of a warmed ophthalmic viscoelastic device to accelerate the unfolding of 1-piece intraocular lenses in the capsular bag, Journal of Cataract & Refractive surgery, 41:2332-
2333, 2015.
0470C002 (Y.Suzuki), M.Taki, M.Kojima:Dosimetry on high-frequency electromagnetic field exposure with micro-
encapsulated thermo-chromic liquid crystal, IEICE technical report, 1-6, 2015.
0470C003 H.Sasaki:Update no multifocal intraocular lenses' development, Journal of Japanese Ophthalmological Society,
119:1;3-5, 2015.
Case Reports 0470D001 H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai, T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.
Presentations at Conference
International Conference (Presentations)
0470I001 H.Sasaki:Standardized classifications and severity scales of cataract , Asia Arvo, Yokohama, 2015.
0470I002 E.Kubo:Regulation of EMT and its possibility for suppression of PCO, Asia Arvo, Yokohama, 2015.
0470I003 E.Kubo:The microRNA regulates the lens development and differentiation, Asia Arvo, Yokohama, 2015.
0470I004 Y.Takahashi:Optical simulation of water clefts, Asia Arvo, Yokohama, 2015.
73 0470I005 (Y.Suzuki), M.Sasaki, S.Onishi, R.Imai, M.Takamura, M.Taki, J.Chakarothai, K.Sasaki, K.Wake, S.Watanabe, M.Kojima, CY,Tsai, H.Sasaki:Acceleration of large-scale multi-physics simulation for biomedical EMC with many-
core architecture based computing, URSI AT-RASC, Canary Istands, 2015.
0470I006 H.Sasaki, E.Shibuya, M.Takahashi, A.Okamoto, N.Mita, N.Hatsusaka, S.Shibata, T.Shibata, K.Sasaki, E.Kubo: Effect of forward light scattering on visual function in eyes with cortical cataract, Association for Research in
Vision and Ophthalology, Denver, 2015.
0470I007 T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:FGF-2 regression of the tropomyosin expression through MAPK/ERK kinase pathway in lens epithelial cells, Association for Research in Vision and
Ophthalology, Denver, 2015.
0470I008 E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expression profiling of lens epithelial cells in a rat posterior capsular opacity model in vivo, Association for Research in Vision and
Ophthalology, Denver, 2015.
0470I009 Y.Seki, T.Shibata, Y.Yabata, M.Sasaki, H.Osada, T.Saruta, H.Asano, E.Kubo, A.Sanyiwa, H.Sasaki:Prevalence of
pinguecula in children living in rural Tanzania, Association for Research in Vision and Ophthalology, Denver, 2015.
0470I010 H.Sasaki, E.Shibuya, M.Takahashi, A.Okamoto, N.Mita, N.Hatsusaka, S.Shibata, T.Shibata, K.Sasaki, E.Kubo: Effect of forward light scattering on visual function ineyes with cortical cataract, Association for Research in Vision
and Ophthalology, Denver, 2015.
0470I011 (B.Chhunchha), E.Kubo, DP.Singh:Nrf2 Accelerater Oxidative Stress And Lens Epithelial Cell Death Through Induction of KLF9-Driver Repression of Prdx6 In Response To Excessive Oxidative Load, Association for
Research in Vision and Ophthalology, Denver, 2015.
0470I012 X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.
0470I013 H.Sasaki, E.Shibuya, M.Takahashi, N.Shibata, Y.Takahashi, S.Shibata, T.Shibata, N.Mita, E.Kubo:Effect of forward
light scattering on visual function in eyes with retrodots, XXXIII Congress of the RSCRS, Barcelona, 2015.
0470I014 (Y.Suzuki), M.Kojima, A.Kik, M.Taki:Non-destructive 3D temperature measurement for dosimetries of the thermal dose due to high frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal,
First PEM International Workshop in Kyoto, Kyoto, 2015.
0470I015 E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expressin profiling of lens epithelial cells in posterior capsular opacity and the role of decorin, The 3rd International Conference on the Lens
2015, Kona, 2015.
0470I016 N.Mita, M.Sasaki, Y.Takahashi, Y.Seki, A.Okamoto, T.Shibata, S.Shibata, E.Kubo, H.Sasaki:Higher-order aberrations in Japanese eyes with cataract and eyes with aspherical intraocular lenses, The 3rd International
Conference on the Lens 2015, Kona, 2015.
0470I017 S.Shibata, N.Shibata, T.Shibata, N.Tanimura, H.Sasaki, E.Kubo:Human age related cataract and decorin: correlations among opacity severity, age and decorin expression, The 3rd International Conference on the Lens
2015, Kona, 2015.
0470I018 H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.
0470I019 E.Shibuya, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, T.Shibata, E.Kubo, H.Sasaki:Influence on visual function by high-order aberration, forward and backward light scattering in eyes with nuclear opacity, The 3rd International
Conference on the Lens 2015, Kona, 2015.
0470I020 N.Hatsusaka, H.Osada, E.Shibuya, A.Okamoto, M.Sasaki, M.Takahashi, A.Nakano, Y.Seki, E.Kubo, H.Sasaki: Lenticular findings in emergency workers at Tokyo Electric Power Fukushima Nuclear Power Plant at 4 years post-
exposure, The 3rd International Conference on the Lens 2015, Kona, 2015.
0470I021 H.Sasaki, H.Asano, T.Hiraoka, H.Osada, T.Shibata, M.Sasaki, Y.Seki, T.Saruta, F.Fujikake, Y.Tabata, T.Oshika, A.Sanyiwa:Mopia and related factors in Tanzanian adults, The 3rd International Conference on the Lens 2015,
Kona, 2015.
74 0470I022 T.Shibata, S.Shibata, H.Sasaki, DP.Singh, E.Kiyokawa, M.Ikawa, E.Kubo:Suppression of injury-induced epithelial- mesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9, The 3rd International
Conference on the Lens 2015, Kona, 2015.
75 0475 Department of Otorhinolaryngology
Faculty
Title Name Field of Specialization Professor MIWA Takaki Otorhinolaryngology, Head and Neck Surgery Professor SUZUKA Yuko Otology, Auditory physiology, Equilibrium neuroscience Associate Professor SHIGA Hideaki Rhinology, Olfactory disorders Senior Assistant Professor MIYAZAWA Toru Otorhinolaryngology Senior Assistant Professor TERAGUCHI Kanako Rhinology, generel otology Assistant Professor YAMAMOTO Junpei General otorhinolaryngology, Olfactory disorders Assistant Professor KINOSHITA Yuko Otorhinolaryngology Assistant Professor NODA Takuya General otorhinolaryngology Assistant Professor YAMADA Kentaro General otorhinolaryngology
Keywords of Research
olfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep apnea & snoar surgery
Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Teraguchi, Yamamoto, Yamada, Noda, Harita)
New educational system for endoscopic sinus surgery(Miwa , Shiga, Teraguchi)
Auditory central functional imaging with MEG(Suzuka, Teraguchi)
Clinical research for snoar and sleep apnea(Miwa, Sakai)
Publications
Originals 0475B001 T.Noda, K.Yamada, J.Yamamoto, T.Miwa, T.Tutumiuti, Y.Shimode, H.Thuzi:A case of mammary analogue
secretory carcinoma with sarcomatoid change, Stomato-pharyngology, 28:2;137-141, 2015.
0475B002 (T.Tokunaga), M.Sakashita, T.Haruna, D.Asaka, S.Takeno, H.Ikeda, T.Nakayama, N.Seki, S.Ito, J.Murata, Y.Sakuma, N.Yoshida, T.Terada, I.Morikura, H.Sakaida, K.Kondo, K.Teraguchi, M.Okano, N.Otori, M.Yoshikawa, K.Hirakawa, S.Haruna, T.Himi, K.Ikeda, J.Ishitoya, Y.Iino, R.Kawata, H.Kawauchi, M.Kobayashi, T.Yamasoba, T.Miwa, M.Urashima, M.Tamari, E.Noguchi, T.Ninomiya, Y.Imoto, T.Morikawa, K.Tomita, T.Takabayashi, S.Fujieda:Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study, Allergy,
70:8;995-1003, 2015.
76
Reviews 0475C001 H.Shiga, T.Miwa:Nasal drug delivery facilitates molecular imaging of olfactory disorders., Nihon Bika Gakkai Kaishi
(Japanese Journal of Rhinology), 54:1;47-51, 2015.
0475C002 H.Shiga, T.Miwa:Epidemiology of Olfactory Disoders, Progress in Medicine, 35:4;619-622, 2015.
0475C003 H.Shiga, T.Miwa:Improving effects of internasal insulin via olfactory nerve pathway on congnitive impairment,
Progress in Medicine, 35:4;701-704, 2015.
Others 0475F001 T.Miwa, J.Yamamoto, K.Teraguchi, Y.Kinoshita, K.Yamada, T.Noda, M.Harita, H.Shiga, E.Sugiyama,
K.Ono:Changes in smell and taste function in the elderly, Chemical Senses, 40:3;261, 2015.
Presentations at Conference
International Conference (Key Note Lecture) 0475G001 T.Miwa:Change in olfactory function in the elderly and anti-aging., 17th Asian Research Symposium in Rhinology,
Beijin, 2015.
International Conference (Synposium) 0475H001 T.Miwa:Treatment of patients with olfactory dysfunction due to chronic rhinosinusitis., 16th World Congress of
Rhinology, Sao Paulo, 2015.
0475H002 H.Shiga, M.Furukawa, T.Miwa:When is the right time to start doctoral research in surgical residency? , The 32nd
Congress of the Pan-Pacific Surgical Association Japan, Honolulu, 2015.
0475H003 T.Miwa:Olfactory impairment in elderly., 13th Japan-Taiwan Conference on Otolaryngology-Head and Neck
Surgery, Tokyo, 2015.
International Conference (Presentations) 0475I001 H. Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, M.Furukawa, S.Kinuya, T.Miwa:Prognostic value of olfactory nerve assessment with olfacto-scintigraphy in patients with olfactory disorders, The 37th annual meeting of the
Association for Chemoreception Sciences, Bonita Sorings, 2015.
0475I002 T.Noda:Effect of kampo medicine "Tokishakuyakusan" on olfactory epithelium in olfactory-impaired mice., 16th
World Congress of Rhinology, Sao Paulo, 2015.
0475I003 K.Yamada:Outcomes of olfactory dysfunction in chronic rhinosinusitis., 16th World Congress of Rhinology, Sao
Paulo, 2015.
0475I004 M.Harita, T.Hiraba, K.Teraguchi, J.Yamamoto, T.Miyazawa, H.Shiga, Y.Suzuka, T.Miwa:Two cases of glomangiopericytoma in nasal cavity, The 32nd Congress of the Pan-Pacific Surgical Association Japan, Honolulu,
2015.
0475I005 Y.Nakamura, T.Noda, K.Yamada, K.Teraguchi, H.Shiga, T.Miwa:Endscopic vasculized nasoseptal flap repair of cerebrospinal fluid leak to anterior skull base meningocele, The 32nd Congress of the Pan-Pacific Surgical
Association Japan , Honolulu, 2015.
0475I006 M.Harita, T.Hiraba, K.Teraguchi, J.Yamamoto, T.Miyazawa, H.Shiga, Y.Suzuka, T.Miwa:Two cases of glomangiopericytoma in nasal cavity., 13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery,
Tokyo, 2015.
77 0485 Department of Head and Neck Surgery
Faculty
Title Name Field of Specialization Professor TSUJI Hiroyuki Head and neck oncology, Head and neck surgery Senior Assistant Professor SHIMODE Yuzo Head and neck oncology, surgery, Thyroid gland tumor research
Keywords of Research
head and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle aspiration cytology, chemoradiotherapy
Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode) New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government cooperation (Tsuji, Shimode) Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji, Shimode) Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)
Publications
Originals 0485B001 T.Noda, K.Yamada, J.Yamamoto, T.Miwa, T.Tutumiuti, Y.Shimode, H.Thuzi:A case of mammary analogue
secretory carcinoma with sarcomatoid change, Stomato-pharyngology, 28:2;137-141, 2015.
0485B002 M.Matoba, H.Tuji, Y.Shimode, T.Kondo, K.Oota, H.Tonami:Lesion regression rate based on RECIST: prediction of treatment outcome in patients with head and neck cancer treated with chemoradiotherapy compared with FDG
PET-CT, Journal of Radiation Research, 56:3;553-560, 2015.
Presentations at Conference
International Conference (Presentations) 0485I001 Y.Shimode, H.Tsuji, M.Takaba:The "SONAVIA" and "SONAVIA Lock-on System" as Assistive Devices for Fine Needle Aspiration Biopsy Cytology for Thyroid Nodular Lesions and Cervical Lymph Nodes, The 32nd Congress of
the Pan-Pacific Surgical Association, Honolulu, 2015.
0485I002 Y.Shimode, H.Tsuji, M.Takaba:The "SONAVIA" and "SONAVIA Lock-on System" as Assistive Devices for Fine Needle Aspiration Biopsy Cytology for Thyroid Nodular Lesions and Cervical Lymph Nodes, 1st Congress of Asia-
Pacific Society of Thyroid Surgery, Seoul, 2015.
78 0490 Department of Dermatology
Faculty
Title Name Field of Specialization Professor MOCHIZUKI Takashi Medical mycology, Dermatomycosis Associate Professor NISHIBU Akiko Immunology Associate Professor WATANABE Seiji Senior Assistant Professor TAKEDA Kiminobu Medical mycology Senior Assistant Professor ISHIZAKI Yasuko Dermatopathology, cutaneous malignant tumor Senior Assistant Professor FUJII Toshiki Dermatopathology Assistant Professor ANZAWA Kazushi Medical mycology Assistant Professor USHIGAMI Tsuyoshi Medical mycology Assistant Professor SHIMADA Toshitsugu Dermatology
Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA, phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor, immunopathology, immunology, Langerhans cell,
Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology. We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data. We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to the epidemics. In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose the phylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understand those species as they are. In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical type of decubitus after surgical operations.
Publications
Originals 0490B001 (R.Kano), C.K.-M.Tsui, R.C.Hamelin, K.Anzawa, T.Mochizuki, K.Nishimoto, M.Hiruma, H.Kamata, A.Hasegawa:The MAT1-1:MAT1-2 ratio of sporothrix globosa isolated in Japan, Mycopathologia, 179:81-86, 2015.
0490B002 (T.Tsukatani), H.Ogawa, K.Anzawa, E.Kobayashi, H.Hasegawa, K.Makimura, T.Yoshizaki, N.Ueda:Schizophyllum commune-induced allergic fungal rhinosinusitis and sinobronchial mycosis, Medical Mycology Case Reports, 8:10-
13, 2015.
79 0490B003 (S.Yamada), K.Anzawa, T.Mochizuki:Survey of dermatophyte infection in cats and dogs in the Fukui region of
Japan, 14:4;166-170, 2015.
0490B004 (T.Iwanaga), K.Anzawa, T.Mochizuki:An investigation of the clinical practice for dermatophytosis treatment using reimbursement data from health insurance societies in Japan, The Japanese Journal of Dermatology, 125:2289-
2299, 2015.
Reviews 0490C001 T.Mochizuki, K.Takeda, K.Anzawa:Molecular markers useful for epidemiology of dermatophytoses, Journal of
Dermatology, 42:232-235, 2015.
0490C002 (A.Chakrabarti), A.Bonifaz, M.Clara G.Galhardo, T.Mochizuki, Y.Song:Global epidemiology of sporotrichosis ,
Medical Mycology , 53:3-14, 2015.
0490C003 T.Mochizuki:Dermatomycoses-Future Trend, 35:12;1847-1852, 2015.
Case Reports 0490D001 H.Mochizuki, T.Ushigami, T.Fujii, T.Mochizuki, N.Wakamatu:A case of angiolemyoma arising on the right heel,
14:4;183-187, 2015.
0490D002 K.Takeda, H.Mochizuki, Y.Sakata, T.Ushigami, A.Nishibu, K.Anzawa, T.Mochizuki, H.Kanakawa, M.Yanagihara:A case of widespread tines corporis caused by Trichophton tonsurans mimicking atopic dermatitis, Journal of
pediatric dermatology, 34:2;29-33, 2015.
0490D003 (A.Takeuchi), K.Anzawa, T.Mochizuki, K.Takehara, Y.Hamaguchi:Chromoblastomycosis caused by Phialophora
verrucosa on the hand, The European Journal of Dermatology , 25:3;274-275, 2015.
0490D004 (M.Inaoki), C.Nishijima, M.Miyake, T.Asaka, Y.Hasegawa, K.Anzawa, T.Mochizuki:Case of dermatophyte abscess
caused by Trichophyton rubrum: a case report and review of the literature, Mycoses, 58:318-323, 2015.
0490D005 Y.Sakata, A.Kitayama, R.Yoshimura, K.Anzawa, T.Fujii, K.Fujimoto, H.Yokoyama, T.Mochizuki:Case of cutaneous phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient, Journal of Dermatology,
42:3;263-266, 2015.
0490D006 K.Tsujioka, R.Tanaka, K.Anzawa, H.Ogura:A case of cutaneous phaeophomycosis caused by exophiala lecanii-
corni showing a seasonal fluctuation of skin lesions, Medical Mycology Journal, 56:4;117-121, 2015.
Others
0490F001 T.Mochizuki :Frontline of dermatomycology research is just in front of us! , Journal of Dermatology, 42:231, 2015.
Presentations at Conference
International Conference (Presentations) 0490I001 K.Takeda, Y.Sakata, J.Watanabe, T.Ushigami, A.Nishibu, K.Anzawa, T.Mochizuki:Molecular polymorphism of Trichophyton rubrum strains cultured from a Japanese patient with multiple lesions based on analysis of the non-
transcribed spacer (NTS) region of ribosomal RNA gene, 19th ISHAM Congress in Melbourne, Melbourne, 2015.
80 0500 Department of Urology
Faculty
Title Name Field of Specialization Professor MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer Professor TANAKA Tatsuro kidney transplantation, endourology Professor SUZUKI Koji kidney stone disease, kidney transplantation, hyperparathyroidism Senior Assistant Professor CHIKAZAWA Ippei general urology Senior Assistant Professor MORITA Nobuyo general urology Assistant Professor SUGA Koudai general urology TACHIBANA Assistant Professor general urology Hiromichi Assistant Professor TOKUNAGA Kousuke general urology Assistant Professor NAKAI Dan general urology Assistant Professor INOUE Shinya general urology Assistant Professor NAKAZAWA Yusuke general urology
Keywords of Research
chronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acute rejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate, crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer, bladder cancer, p53, urinary incontinence,
Outline of Research
clinical research on renal transplantation, mechanism of urolithiasis
Publications
Originals 0500B001 N.Morita, S.Kuwasaki, S.Inoue, Y.Nakazawa, D.Nakai, H.Tachibana, I.Chikazawa, T.Tanaka, K.Miyazawa:Clinical experience of sunitinib in patients with advanced renal cell carcinoma, Japanese journal of urological surgery,
28:11;1813-1817, 2015.
0500B002 Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, Y.Motoo, K.Miyazawa:Initial experience of enzalutamide in patients with castration resisitant prostate cancer, Journal of
Kanazawa Medical University, 40:2・3;196-200, 2015.
Case Reports 0500D001 I.Chikazawa, S.Inoue, Y.Nakazawa, D.Nakai, H.Tachibana, K.Suga, N.Morita, T.Tanaka, K.Miyazawa, K.Sato:A
case of mucinous tubular and spindle cell carcinoma, Japanese journal of urological surgery, 28:1;99-102, 2015.
81 Presentations at Conference
International Conference (Presentations) 0500I001 K.Miyazawa:JUA Guidelines on Urolithiasis 2013 edition, Advancements in Urology2015 - an AUA/JUA
Symposium, Honololu, 2015.
0500I002 K.Miyazawa:Stone controversy: Lower pole stones and proximal ureteral stones., Advancements in Urology2015-
an AUA/JUA Symposium, Honololu, 2015.
0500I003 K.Miyazawa:Case-Based discussion: Challenging stone cases., Advancements in Urology 2015 - an AUA/JUA
Symposium, Honololu, 2015.
0500I004 S.Inoue:Stone Controversy-Ureteral stent after URS for proximal ureteral stone., Advancements in Urology 2015 -
an AUA/JUA Symposium, Honololu, 2015.
0500I005 Y.Nakazawa:SWL and Endourology (PCNL or URS) for proximal ureteral stone?, Advancements in Urology 2015 -
an AUA/JUA Symposium, Honololu, 2015.
0500I006 K.Miyazawa:Role of protease-activated receptors for calcium oxalate stone formation in tubular epithelial cells.,
USANZ2015 68th Annual Scientific Meeting, Adelaide, 2015.
82 0510 Department of Obstetrics and Gynecology
Faculty
Title Name Field of Specialization Gynecologic Pathology, Tumor Virology, Sexually Transmitted Professor SASAGAWA Toshiyuki Infection Research, Immunology Senior Assistant Professor OKA Yasuko perinatal medicine, reproductive medicine Senior Assistant Professor TAKAGI Hiroaki perinatal medicine, reproductive medicine, gynecologic oncology Senior Assistant Professor TOMIZAWA Hideki perinatal medicine, reproductive medicine Senior Assistant Professor FUJITA Satoko perinatal medicine, reproductive medicine Assistant Professor SHIBATA Takeo perinatal medicine,reproductive medicine Assistant Professor NEYATANI Natsuko perinatal medicine, climacteric medicine Assistant Professor YAMAGUCHI Naotaka perinatal medicine Assistant Professor OSAKA Yasuhiro perinatal medicine Assistant Professor SAKAMOTO Jinichi perinatal medicine, reproductive medicine
Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation, postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition and metabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms, mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis
Outline of Research
83 Presentations at Conference
International Conference (Presentations) 0510I001 H.Takagi, T.Sasagawa, T.Shibata, S.Makinoda:Usefulness of PET/CT SUV and prognostic factors in patients with endometrial cancer (endometrioid adenocarcinoma), FIGO 2015, 21st Gynecology & Obstetrics World Congress,
Vancouver, 2015.
0510I002 Y.Oka, S.Makinoda:A trial of preoperative diagnosis of uterine sarcoma using tumor signal intensity at Magnetic
Resonance Imaging (MRI)), 25th World Congress on Ultrasound in Obstetrics and Gynecology, Montreal, 2015.
0510I003 Y.Osaka, T.Maehama, H.Ito, H.Kobayashi, T.Sasagawa:An accuracy of hybrid capture-2 (HC-2)and cobas HPV
tests used for cervical cancer screening in Japan, Internatioal papillomavirus conference, Lisbon, 2015.
0510I004 T.Shibata, S.Makinoda:Change in myeloperoxidase index in polymorphonuclear neutrophils during the normal menstrual cycle, FIGO 2015, 22st Gynecology & Obstetrics World Congress, Vancouver, 2015.
0510I005 H.Takagi, T.Sasagawa, T.Shibata, S.Makinoda:Usefulness of PET/CT SUV and prognostic factors in patients with endometrial cancer (endometrioid adenocarcinoma), FIGO 2015, 21st Gynecology & Obstetrics World Congress,
2015.
84 0520 Department of Anesthesiology and Perioperative Medicine
Faculty
Title Name Field of Specialization Professor TSUCHIDA Hideaki Cardiovascular effects of anesthetics Senior Assistant Professor OGAWA Masao Clinical anesthesia, Palliative medicine Senior Assistant Professor KIDA Hiromasa Clinical anesthesia, Pediatric anesthesia, Shock Senior Assistant Professor HONMA Keiko Clinical anesthesia, Palliative medicine Assistant Professor ARAKI Hideharu Clinical anesthesia Assistant Professor TAKANO Mami Clinical anesthesia Assistant Professor TANAKA Yasunori Clinical anesthesia Assistant Professor HIRAMATSU Akiko Clinical anesthesia Assistant Professor HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity Assistant Professor TAKAHARA Asami Clinical anesthesia Assistant Professor MURATA Yuriko Clinical anesthesia Assistant Professor MORIKAWA Takanori Clinical anesthesia Assistant Professor YAMAOKA Yuko Clinical anesthesia, Palliative medicine Assistant Professor YUGI Haruka Clinical anesthesia Assistant Professor UEDA Keiko Clinical anesthesia
Keywords of Research
anesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care, postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide
Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics in perioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics and prognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock on vasoreactivity in the rat thoracic aorta or the mesenteric arteriole.
Publications
Reviews 0520C001 M.Ogawa, H.Tsuchida:Present situation and problems of perioperative risk stratification models, Journal of
Kanazawa Medical University, 40:2・3;149-153, 2015.
Case Reports 0520D001 (A.Shirai), M.Ogawa, K.Hirota, T.Yoshizaki, K.Ogawa:Efficacy of jiinshihoto in patients with glossodynia and abnormal sensation in the throat : Three case reports, Journal of the Japan Society for Oriental Medicine, 66:1;22-
27, 2015.
85 Presentations at Conference
International Conference (Presentations) 0520I001 M.Ogawa, H.Tsuchida:Patient age influences the relationship between the Surgical Apgar Score and postoperative
major complications, Euroanaesthesia 2015 (European Society of Anesthesiology), Berlin, 2015.
86 0540 Department of Physical and Rehabilitation Medicine
Faculty
Title Name Field of Specialization rehabilitation medicine, osteoporosis, disuse syndrome, higher brain Professor KAGECHIKA Kenji dysfunction
Keywords of Research
gait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neck fracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL,
Outline of Research
１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during walking cycle. ２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patient with osteoarthritis of the hip who underwent hip surgery． ３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about the outcome, then to improve this clinical pathway, for the patient to return home with satisfaction. ４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination of swallowing. Secondly, we are going to establish the standard of indication for swallowing training.
Publications
Originals 0540B001 A.Kura, K.Sasaki, T.Kimura, A.Kobe, K.Kagechika:Kinematical characteristics of lower extremity in females with anterior cruciate ligament reconstruction during stair descent: Changes in joint ROM of the lower extremity ,
Rigakuryoho Kagaku, 30:1;85-89, 2015.
0540B002 K.Okamoto, K.Nakatani, N.Sunahara, M.Notoya, K.Inoue, K.Kagechika:Effects of auditory stimulation by white noise in the rehabilitation of unilateral spatial neglect patients, Journal of the Tsuruma Health Science Society,
39:1;87-92, 2015.
Presentations at Conference
International Conference (Presentations) 0540I001 A.Kobe, N.Yamazaki, C.Yamamoto, Y.Funami, K.Kagechika, T.Maeno, P.T.Inaoka:Falls incidents between a rehabilitation department and entire hospital:A five year comparative study, World Confederation for Physical
Therapy 2015, Singapore, 2015.
0540I002 Y.Izaki, K.Kyoda, K.Kagechika:Analysis of Kanji reading in a case of alexia with agraphia of Kanji in the lesion of the left inferior temporal gyrus-Using the Sophia Analysis of Language in Aphasia(SALA)-, 9th World Congress of
the International Society of Physical and Rehabilitation Medicine, Berlin, 2015.
0540I003 K.Kagechika, T.Nakaki, M.Tsubokawa, A.Nakaki, Y.Takagi:Effect of rehabilitation fo blood cancer, 9th World
Congress of the International Society of Physical and Rehabilitation Medicine, Berlin, 2015.
87 0550 Department of Emergency Medicine
Faculty
Title Name Field of Specialization Professor WATOH Yukihiro Emergency, Emergency medical syctem, Disaster Medicine Senior Assistant Professor MASHIBA Satoru Emergency, Anaphylaxis Assistant Professor GOTO Tetsuro Emergency Assistant Professor MURASAKA Kenshi Emergency, Neurosurgery Assistant Professor MORITA Hideki Emergency Assistant Professor WATANABE Atsushi Emergency
Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care,
Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.
Publications
Originals 0550B001 (Y.Takei), T.Nishi, T.Kamikura, Y.Tanaka, Y.Wato, M.Kubo, M.Hashimoto, H.Inaba:Do early emergency calls
before patient collapse improve survival after out-of-hospital cardiac arrests?, Resuscitation, 88:20-27, 2015.
88 0570 Community Medicine
Faculty
Title Name Field of Specialization Professor KANDA Tsugiyasu Cardiovascular distase, Diabetes Mellitus, Mental distase Senior Assistant TAKAHASHI clinical respiratory medicine, pulmonary tuberculosis Professor(Additional Post) Masakatsu Assistant USUDA Daisuke Professor(Additional Post)
Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy,
Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinical field. 1. The treatment of heart failure with myocarditis in an animal model. 2. The treatment trial of cytokine regulation in the atherosclerosis. 3. The cytokine treatment against chronic fatigue syndrome.
Publications
Originals 0570B001 T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda, S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.
89 0575 Department of Gastroenterological Endoscopy
Faculty
Title Name Field of Specialization Diagnosis for esophagus, gastro-intestine, colon, liver & bileduct Professor ITO Tohru disease. Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Associate Professor KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Associate Professor URASHIMA Sachio Diagnosis for esophagus, Hepato-biliary-pancreatic treatment Diagnosis for esophagus, gastro-intestine, colon, disease. Senior Assistant Professor KAWAURA Ken Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor HAMADA Kazu Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor AZUKISAWA Sadafumi Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor KOBAYASHI Rika Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer
Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR
Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon) 2.A study for endoscopical treat ment of early digestive organ cancer. (Esophagus,Stomach,Colon) 3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)
Publications
Originals 0575B001 K.Hamada, T.Itoh, H.Kitakata, K.Kawaura, S.Azukisawa, R.Itoh, H.Okamura, S.Urashima:Examination of dark reddish-brown urine (RBU) caused by endoscopic submucosal dissection (ESD), ENDOSCOPIC FORUM for
digestive disease, 31:1;33-39, 2015.
0575B002 T.Itoh, H.Kitakata, S.Kinami, K.Kawaura, K.Hamada, S.Azukisawa, R.Itoh, K.Omote, T.Kosaka, M.A.Fujino:New treatment strategy for submucosa-infiltrating gastric cancer without sentinel node metastasis: A pilot study of laparoscopy-assisted endoscopic full-thickness resection in an IN VIVO porcine model., ENDOSCOPIC FORUM
for digestive disease, 31:1;17-26, 2015.
90 Presentations at Conference
International Conference (Synposium) 0575H001 T.Ito, K.Kawaura, S.Azukisawa, K.Hamada, H.Kitakata, R.Ito:Endoscopical diagnosis & treatment for
undifferentiated adenocarcinoma of stomach., The 17th Japan-Russia Endoscopy Symposium, Moscow, 2015.
International Conference (Presentations) 0575I001 T.Ito:Dianosis of SM gastric cancer and novel technology of EFTR for SM gastric cancer., Suegical endoscopy and
mini-invasive surgery:state of the art, Firenze, 2015.
91 0580 Department of Oral and Maxillofacial Surgery
Faculty
Title Name Field of Specialization oral and maxillofacial surgery, temporomandibular joint disorders, oral Professor SEGAMI Natsuki cancer, orthognathic surgery Associate Professor MATSUMOTO Gouichi Bone Regeneration, Biomaterials, Oral Cancer Associate Professor ISHIBASHI Hiroaki Oral tumor, Oral Pathology Associate Professor DEMURA Noboru orthodontics, stomatology Assistant Professor KATO Koichiro Oral tumor Assistant Professor HASUMOTO Miho Orthodontics Assistant Professor KATO Takao Oral cavity, Kampo medicines, Dental pharmacology
Keywords of Research
stomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonance imaging, oral cancer, metastasis, orthognathic surgery, kampo medicines, dental pharmacology
Outline of Research
1. Basic and clinical research for disorders of temporomandibular joints. 2. Molecular biological research for growth and metastasis of tumors in oral region. 3. Pathophysiological research for abnormal development of oral and maxillofacial region. 4. Research for surgical orthognathics for jaw deformity. 5. Integration mechanisms of oral sensory information in the central nervous systems. 6. Studies on the pharmacological mechanism of Kampo medicines.
Publications
Originals 0580B001 G.Matsumoto, T.Ueda, Y.Sugita, K.Kubo, M.Mizoguchi, E.Kotani, N.Oda, Shin Kawamata, N.Segami, H.Mori:Polyhedral microcrystals encapsulating bone morphogenetic protein 2 improve healing in the alveolar ridge,
Journal of Biomaterials Applications, 30:2;193-200, 2015.
92 University Hospital 0635 Hepatology
Faculty
Title Name Field of Specialization Professor TSUTSUMI Mikihiro Mechanism of alcoholic liver disease TSUCHISHIMA Professor Anti-viral therapy of viral hepatitis Mutsumi Associate Professor TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma Associate Professor SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer Associate Professor OZAKI Kazuaki Mechanism of portal hypertention in alcoholic liver injury Senior Assistant Professor JOSEPH George Mechanism of hepatic fibrosis Senior Assistant Professor HAYASHI Nobuhiko Mechanism of nonalcoholic fatty liver disease Senior Assistant Professor SAITO Takashi Treament for metabolic syndrome Senior Assistant Professor FUKUMURA Atsushi Etiology and clinical feature of acute hepatitis
Keywords of Research
alcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholic steatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment, treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis
Outline of Research
１ Basic and clinical study of digestive disease ①Treatment for esophageal and gastric varices associated with portal hypertension ②Hepatic support system for severe alcoholic hepatitis ③Clinical feature and treatment for nonalcoholic steatohepatitis ２ Experimental study of alcoholic organ injury ①Pathogenesis and treatment for alcoholic hepatitis ②Pathogenesis of hepatic fibrosis induced by alcohol ③Effect of alcohol on chemical carcinogenesis of the liver ３ Pathogenesis for nonalcoholic steatohepatitis
Publications
Originals 0635B001 N.Kawada, H.Uehara, T.Hosoki, M.Takami, H.Shiroeda, T.Arisawa, Y.Tomita:Usefulness of Dual-Phase F-18-
FDG PET/CT for Diagnosing Small Pancreatic Tumors, Pancreas, 44:4;655-659, 2015.
0635B002 M.Nakamura, T.Tahara, H.Shiroeda, K.Matsunaga, T.Otsuka, J.Yonemura, T.Shibata, T.Arisawa:The effect of short-term proton pump inhibitor plus anti-ulcer drug on the healing of endoscopic submucosal dissection-derived
artificial ulcer: A randomized controlled trial, Hepato-Gastroenterology, 62:137;219-224, 2015.
93 0635B003 N.Kawada, H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita:Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not
with development of pancreatic ductal adenocarcinoma, Pancreatology, 15:6;654-660, 2015.
0635B004 Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George:Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, PLoS
One, 10:3;e0118744, 2015.
0635B005 N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi:Serum endocan as a survival predictor for patients with liver
cirrhosis, Canadian Journal of Gastroenterology and Hepatology, 29:8;427-430, 2015.
0635B006 N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis and
Thrombosis, 22:10;1051-1060, 2015.
Reviews 0635C001 M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi:Toxic AGEs (TAGE) theory in the
pathogenesis of NAFLD and ALD, International Journal of Diabetes and Clinical Researsh, 2:4;1-5, 2015.
94 0675 Health Evaluation Center
Faculty
Title Name Field of Specialization Professor ASAJI Takayoshi Heartfailure Professor FURUTA Hisakazu Clinical study on sleep-wake disorders Assistant Professor ISHIKAWA Kaori Preventive medicine Associate Professor NAKANISHI Yumiko Preventive medicine Professor MORIKAWA Yuko Cardiovascular epidemiology, occupational medicine (Additional Post) Associate Professor NISHIJO Muneko Environmental epidemiology, epidemiology of cadmium pollution (Additional Post) Associate Professor ISHIZAKI Masao Occupational health, Epidemiology for cardiovascular disease (Additional Post) Associate Professor SAKURAI Masaru Cardiovascular epidemiology, preventive cardiology (Additional Post) Assistant Professor NAGASAWA Shinya Cardiovascular epidemiology, preventive cardiology
Keywords of Research
health examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking, alcohol intake, life style, stress, dietary habits, nutrient intake, exercise
Outline of Research
Studies for improvement of total medical check system and method of health support.
Publications
Originals 0675B001 Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.
0675B002 K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.
0675B003 PT.Tai, M.Nishijo, NTN.Anh, TN.Nghi, HV.Luong, TH.Anh, VT.Nguyen, H.Nishijo:Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at 1 year of age, Science of the Total Environment, 536:575-581,
2015.
0675B004 (A.Takazakura), M.Sakurai, Y.Bando, H.Misu, Y.Takeshita, Y.Kita, A.Shimizu, T.Hayakawa, K.Kato, S.Kaneko, T.Takamura:Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic
nephropathy, Journal of Diabetes Investigation, 6:3;346-353, 2015.
0675B005 SY.Nagasawa, T.Ohkubo, K.Masaki, E.Barinas-Mitchell, K.Miura, T.Seto, A.El-Saed, T.Kadowaki, BJ.Willcox, D.Edmundowicz, A.Kadota, RW.Evans, S.Kadowaki, A.Fujiyoshi, T.Hisamatsu, MH.Bertolet, T.Okamura, Y.Nakamura, LH.Kuller, H.Ueshima, A.Sekikawa; ERA-JUNP Study Group:Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white,Japanese-American and Japanese men: The ERA-
JUMP study, Journal of Atherosclerosis Thrombosis, 22:6;590-598, 2015.
95 0675B006 M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido, H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.
0675B007 (K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice for
renal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.
0675B008 N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis and
Thrombosis, 22:10;1051-1060, 2015.
0675B009 (M.Satoh), T.Ohkubo, K.Asayama, Y.Murakami, M.Sakurai, H.Nakagawa, H.Iso, A.Okayama, K.Miura, Y.Imai, H.Ueshima, T.Okamura; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH?JAPAN) Research Group:Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: Evidence for cardiovascular prevention from observational cohorts in
Japan., Hypertension, 65:3;517-524, 2015.
0675B010 (T.Hisamatsu), K.Miura, A.Fujiyoshi, T.Okamura, T.Ohkubo, SY.Nagasawa, M.Horie, A.Okayama, H.Ueshima; NIPPON DATA80 Research Group:Long-term outcomes associated with prolonged PR interval in the general
Japanese population, International Journal of Cardiology, 184:291-293, 2015.
0675B011 (HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo, H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.
0675B012 TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa, T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.
0675B013 M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using a mixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.
0675B014 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.
0675B015 (IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination for
survival data, Biometrical Journal, 57:4;592-613, 2015.
0675B016 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause mortality increased by environmental cadmium exposure in the Japanese general population in cadmium non-
polluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.
Reviews 0675C001 (C.Chen),P.Xun, M.Nishijo, A.Sekikawa, K.He:Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case-control studies among individuals without occupational exposure history,
Environmental Science and Pollution Research, 22:22;17465-17474, 2015.
0675C002 (K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.
Presentations at Conference
International Conference (Synposium)
96 0675H001 M.Nishijo:History of Cd pollution and health effect., A Symposium on Health Effects among Cadmium Exposed
Inhabitants in Mae Sot District,Tak Province,Thailand, Mae Sot Thailand, 2015.
0675H002 M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in the Cadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.
International Conference (Presentations) 0675I001 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
0675I002 SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.
0675I003 Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd
International Symposium on Shiftwork and Working Time, Elsinore, 2015.
0675I004 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
0675I005 (TT.Pham), M.Nishijo, MT.Do, NT.Pham, VL.Hoang, HA.Tran, VL.Nguyen, NN.Tran, VK.Tran, TT.Dang, TL.Nguyen, H.Nishijo, H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium
on Halogenated Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.
0675I006 TN.Nghi, PT.Tai, PN.Thao, M.Nishijo:Dioxin concentration in breast milk and umbilical cord blood samples of mother-baby pairs living near Bien Hoa Airport., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vientnam, Hanoi, 2015.
0675I007 M.Nishijo, TN.Nghi, PN.Thao, PT.Tai, AH.Tran, HV.Luong, H.Nishijo:Dioxin effects on groeth and neurodevelopment of infants and children in Vietnam., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vietnam, Hanoi, 2015.
97
Medical Research Institute
7100 Department of Life Sciences
Faculty
Title Name Field of Specialization Molecular mechanism of flavivirus replication, interaction with host Professor TAKEGAMI Tsutomu cells and viral carcinogenesis Professor ISHIGAKI Yasuhito Molecular and Cellular Biology Professor TANAKA Keiko Clinical neurology, Neuroimmunology Associate Professor OTA Takahide Molecular analysis of the mechanism of cancer metastasis Protein regulation by the post-translational modifications and its Associate Professor TASAKI Takafumi underlying molecular mechanisms Senior Assistant Professor MIYAGOSHI Minoru Cell biology Senior Assistant Professor TANIGUCHI Makoto Molecular and Cellular Biology, Lipid Biochemistry
Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA, centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells, RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis, ultra micro structure, mouse germ cells, DNA repair, fibroblast growth factor, tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy
Outline of Research
１．Study on viral replication and pathogenicity ２．Molecular mechanism of carcinogenesis and metastasis ３．Research on plolyploidization and polyploid cells ４．Analyses of transcription and mRNA decay ５．Protein regulation by the post-translational modifications and its underlying molecular mechanisms
Books
7100A001 (J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn:Unraveling the specific role of sphingomyelins in cell physiology: Where are we?, Sphingolipids: Biology, Synthesis and Functions
(Angel Catalá), 91-128, America, 2015.
7100A002 T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.
7100A003 (H.Sawai), M.Taniguchi, T.Okazaki:Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders, Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao,
Lina Marie Obeid), 23-51, Bundesrepublik Deutschland, 2015.
98 Publications
Originals 7100B001 Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.
7100B002 J.Zhang, Y.Ishigaki, T.Takegami:Hepatitis C virus NS3 protein modulates the biological behaviors of malignant
hepatocytes by altering the expression of host cell microRNA, Molecular Medicine Reports, 12:4;5109-5115, 2015.
7100B003 (N.Tachibana), M.Kinoshita, F.Kametani, K.Tanaka, Y.Une, Y.Komatsu, Y.Kobayashi, S.Ikeda:Expression of N- methyl-D-aspartate receptor subunits in the bovine ovum: Ova as a potential source of autoantigens causing anti- NMDAR encephalitis., The Tohoku Journal of Experimental Medicine, 235:3;223-231, 2015.
7100B004 (R.Matsuda), T.Kezuka, A.Umazume, Y.Okunuki, H.Goto, K.Tanaka:Clinical profile of anti-myeli oligodendrocyte glycoprotein antibody seropositive cases of optic neuritis., Neuro-Ophthalmology, 39:5;213-219, 2015.
7100B005 (H.Nakajima), M.Motomura, K.Tanaka, A.Fujikawa, R.Nakata, Y.Maeda, T.Shima, A.Mukaino, S.Yoshimura, T.Miyazaki, H.Shiraishi, A.Kawakami, A.Tsujino:Antibodies to myelin oligodendrocyte glycoprotein in idiopathic
optic neuritis, BMJ Open, 5:4;1-4, 2015.
7100B006 (RS.Tsuburaya), N.Miki, K.Tanaka, T.Kageyama, K.Irahara, S.Mukaida, K.Shiraishi, M.Tanaka:Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in a Japanese boy with recurrent optic neuritis, Brain &
Development, 37:1;145-148, 2015.
7100B007 (S.Nukuzuma), S.Sugiura, K.Nakamichi, M.Kameoka, C.Nukuzuma, T.Tasaki, T.Takegami:Replication of IMR-32-
adapted JC virus clones in human embryonic kidney cells, Microbiology and Immunology, 59:4;238-242, 2015.
7100B008 T.Ota, M.Maeda, M.Okamoto, M.Tatsuka:Positive regulation of Rho GTPase activity by RhoGDIs as a result of
their direct interaction with GAPs, BMC Systems Biology, 9:3, 2015.
7100B009 Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.
7100B010 M.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.Okazaki:Lysososomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in
natural killer/T lymphoma cell apoptosis, Cell Death and Disease, 6:e1717;1-12, 2015.
7100B011 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.
7100B012 J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International, 2015:191489, 2015.
7100B013 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.
7100B014 F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.
7100B015 H.Ogiso, M.Taniguchi, T.Okazaki:Analysis of lipid-composition changes in plasma membrane microdomains,
Journal of Lipid Research, 56:8;1594-1605, 2015.
99 7100B016 Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.
Reviews 7100C001 K.Tanaka:Recent update on autoimmune encephalitis/encephalopathy, Clinical and Experimental
Neuroimmunology, 6:70-82, 2015.
7100C002 (K.Tazaki), M.Nakano, T.Takehara, Y.Ishigaki, H.Nakagawa:Experimental analysis of plastic materials containing
radionuclides for decontamination viability, 69:2;99-108, 2015.
7100C003 (K.Kitatani), M.Taniguchi, T.Okazaki:Role of sphingolipids and metabolizing enzymes in hematological
malignancies, Molecules and Cells, 38:6;482-495, 2015.
7100C004 Y.Nakmaura, T.Tatsuno, Y.Ishigaki:Scanning electron microscopy observation with ionic liquid, Journal of
Kanazawa Medical University, 40:2,3;125-130, 2015.
Case Reports 7100D001 (R.Matsumoto), N.Mikuni, K.Tanaka, K.Usami, K.Fukao, T.Kunieda, Y.Takahashi, S.Miyamoto, H.Fukuyama, R.Takahashi, A.Ikeda:Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody,
Epileptic Disorders, 17:1;89-94, 2015.
7100D002 (H.Yaguchi), K.Tsuzaka, S.Shirai, M.Niino, T.Takahashi, K.Tanaka, I.Yabe, H.Sasaki :Importance of T1-MRI enhanced pyramidal tracts in differential diagnosis as to paraneoplastic encephalomyelitis,
Clinical Neurology and Neurosurgery, 132:9-11, 2015.
7100D003 S.Nakada, H.Minato, T.Takegami, N.Kurose, H.Ikeda, M.Kobayashi, Y.Sasagawa, T.Akai, T.Kato, N.Yamamoto, T.Nojima:NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma
with late distant metastases, Brain Tumor Pathology, 32:4;268-274, 2015.
Short Communications 7100E001 K.Tanaka:Debate on the pathogenesis of paraneoplastic cerebellar degeneration with anti-Yo antibody:T-cell
mediated or antibody mediated?, Clinical and Experimental Neuroimmunology, 6:3;222-224, 2015.
7100E002 (M.Tanaka), M.Kinoshita, K.Tanaka:Corticosteroid and tacrolimus treatment in neuromyelitis optica related
disorders., Multiple Sclerosis Journal, 21:5;669, 2015.
7100E003 （M.Tanaka）, M.Kinoshita, JF.Foley, K.Tanaka, J.Kira, WM.Carroll:Body weight-based natalizumab treatment in
adult patients with multiple sclerosis, Journal of neurology, 262:3;781-782, 2015.
7100E004 (M.Tanaka), M.Kinoshita, K.Tanaka:Anti-John Cunningham virus index in Japanese patients with multiple sclerosis
and neuromyelitis optica-related disorder., Clinical and Experimental Neuroimmunology, 6:3;309-311, 2015.
7100E005 M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada, M.Matsui:Intractable cough as Characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum
disorder., Multiple Sclerosis Journal, 22:4;576-577, 2015.
7100E006 (H.Yoshida), Y.Ishigaki, A.Takizawa, K.Moro, Y.Kishi, T.Takahashi, H.Matsui:Comparative genomics of the mucoid and nonmucoid strains of streptococcus pyogenes, isolated from the same patient with streptococcal
meningitis, 3:2;e00221-15, 2015.
Others 7100F001 K.Tanaka:Pathogenesis of autoantibodies in autoimmune encephalopathies, Annual report of the Japan Epilepsy
Research Foundation, 26:83-90, 2015.
100 Presentations at Conference
International Conference (Synposium) 7100H001 K.Tanaka, Yongzhi Li, N.Kato:Memory disturbance in mice treated with intraventricular administration of CSF
from NMDAR-encephalitis patients, The Lancet Neurology Autoimmune Disorders Conference, Balcerona, 2015.
International Conference (Presentations) 7100I001 K.Tsutsui, M.Fujita, T.Kanbayashi, M.Matsui, K.Tanaka.:Clinical features of anti-NMDAR antibody-positive patients predominantly presenting with chronic psychosis and acute exacerbations., The Lancet Neurology
Autoimmune Disorders Conference, Balcerona, 2015.
7100I002 K.Tanaka, M.Fujita, K.Tsutsui, T.Kanbayashi, M.Matsui:Clinical Features of Anti-NMDAR Antibody-positive Patients Predominantly Presenting Chronic Psychosis with Acute Exacerbations, 67th AAN Annual Meeting,
Washington, 2015.
7100I003 X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.
7100I004 T.Okazaki, L.O.Waedhani, M.Hashimoto, K.Kitatani, H.Ogiso, Y.Ueda, M.Taniguchi:Enhancement of infiltration of malignant lymphoma cells in the mouse liver by sphingomyelin deficiency through sphingomyelin synthase2 (SMS2),
56th International Conference on the Bioscience of lipids, Puerto Iguzu, 2015.
101 7200 Department of Advanced Medicine
Faculty
Title Name Field of Specialization Professor(Additional Post) OKAZAKI Toshiro Hematology and Immunology, Hematology/Oncology Professor TAKEUCHI Masayoshi AGEs, Life style-related disease Professor(Additional Post) MOTOO Yoshiharu Clinical Oncology, Gastroenterology, Cancer Cell Biology Associate Professor SHIMASAKI Takeo Medical Oncology, Gastroenterology, BioInformatics Associate Professor NIIDA Yo Genetic disease, Genetic diagnosis Assistant Professor UEDA Tadashi cardiac muscle, lung, cell biology, cytochemistry Deveropment of the method for diacrisis and therapy of the Assistant Professor TAKATA Takanobu intractable disease by 'Ptoteome Analysis' Assistant Professor SAKASAI Akiko AGEs, Cell Biology Assistant Professor OZAKI Mamoru cytogenetics, Molecular cytogenetics Professor TOMOSUGI Naohisa Clinical Proteomics
Keywords of Research
renal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis, anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinical oncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality, karyotype,
Outline of Research
１．Heart failure by autoimmune pathway related with G-protein ２．Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient ３．The role of AGE in the prevention of lifestyle related disease ４．Clinical research for the diagnosis and treatment of pancreatic cancer ５．Development and clinical application of fetal DNA diagnosis using mother’s blood ６．Genetic diagnosis and analysis of hereditary developmental disability ７．Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type of reciprocal translocation
Books
7200A001 (J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn:Unraveling the specific role of sphingomyelins in cell physiology: Where are we?, Sphingolipids: Biology, Synthesis and Functions
(Angel Catalá), 91-128, America, 2015.
7200A002 (H.Sawai), M.Taniguchi, T.Okazaki:Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders, Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao,
Lina Marie Obeid), 23-51, Bundesrepublik Deutschland, 2015.
102 Publications
Originals 7200B001 T.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.Ueda:Prospective clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku
Hematology Oncology Study Group, Medical Oncology, 32:232-238, 2015.
7200B002 (H.Sawai), H.Ogiso, T.Okazaki:Differential changes in sphingolipids between TNF-induced necroptosis and
apoptosis in U937 cells and necroptosis-resistant sublines, Leukemia Research, 39:964-970, 2015.
7200B003 Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.
7200B004 (T.Suzuki), A.Yamamoto, M.Ohsawa, Y.Motoo, H.Mizukami, T.Makino:Ninjin'yoeito and ginseng extract prevent
oxaliplatin-induced neurodegeneration in PC12 cells, Journal of Natural Medicines, 69:4;531-537, 2015.
7200B005 (M.Kuroda), M.Shimizu, N.Inoue, I.Ikeno, H.Nakagawa, A.Yokoi, Y.Niida, M.Konishi, H.Kaneda, N.Igarashi, J.Yamahana, H.Taneichi, H.Kanegane, M.Ito, S.Saito, K.Furuichi, T.Wada, M.Nakagawa, H.Yokoyama, A.Yachie:Serum tau protein as a marker of disease activity in enterohemorrhagic Escherichia coli O111-induced
hemolytic uremic syndrome, Neurochemistry International, 85-86:24-30, 2015.
7200B006 (S.Y.Kong), M.Takeuchi, H.Hyogo, G.McKeown-Eyssen, S.Yamagishi, K.Chayama, P.J.O'Brien, P.Ferrari, K.Overvad, A.Olsen, A.Tjonneland, M.Boutron-Ruault, N.Bastide, F.Carbonnel, T.Kuehn, R.Kaaks, H.Boeing, K.Aleksandrova, A.Trichopoulou, P.Lagiou, E.Vasilopoulou, G.Masala, V.Pala, M.D.Magistris, R.Tumino, A.Naccarati, H.B.Bueno-De-Mesquita, P.H.Peeters, E.Weiderpass, J.R.Quiros, P.Jakszyn, M.Sanchez, M.Dorronsoro, D.Gavrila, E.Ardanaz, M.Rutegard, H.Nystroem, N.Wareham, K.Khaw, K.Bradbury, I.Romieu, H.Freisling, F.Stavropoulou, M.J.Gunter, A.J.Cross, E.Riboli, M.Jenab, W.R.Bruce:The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk, Cancer Epidemiology
Biomarkers & Prevention, 24:12;1855-1863, 2015.
7200B007 (M.Kajikawa), A.Nakashima, N.Fujimura, T.Maruhashi, Y.Iwamoto, A.Iwamoto, T.Matsumoto, N.Oda, T.Hidaka, Y.Kihara, K.Chayama, C.Goto, Y.Aibara, K.Noma, M.Takeuchi, T.Matsui, S.Yamagishi, Y.Higashi:Ratio of serum
levels of AGEs to soluble form of RAGE is a predictor of endothelial function, Diabetes Care, 38:1;119-125, 2015.
7200B008 (K.Fukami), S.Yamagishi, K.Sakai, Y.Kaida, M.Yokoro, S.Ueda, Y.Wada, M.Takeuchi, M.Shimizu, H.Yamazaki, S.Okuda:Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular
Injury in Hemodialysis Patients, Journal of Cardiovascular Pharmacology, 65:3;289-295, 2015.
7200B009 (J.Takino), K.Nagamine, M.Takeuchi, T.Hori:In vitro identification of nonalcoholic fatty liver disease-related
protein hnRNPM, World Journal of Gastroenterology, 21:6;1784-1793, 2015.
7200B010 (Y.Koriyama), A.Furukawa, M.Muramatsu, J.Takino, M.Takeuchi:Glyceraldehyde caused Alzheimer's disease-like
alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells, Scientific Reports, 5:1-7, 2015.
7200B011 (H.Kan), S.Yamagishi, A.Ojima, K.Fukami, S.Ueda, M.Takeuchi, H.Hyogo, H.Akita, K.Chayama:Elevation of serum levels of advanced glycation end products in patients with non-B or non-C hepatocellular carcinoma,
Journal of Clinical Laboratory Analysis, 29:6;480-484, 2015.
7200B012 (N.Tahara), S.Yamagishi, N.Kodama, A.Tahara, A.Honda, Y.Nitta, S.Igata, T.Matsui, M.Takeuchi, H.Kaida, S.Kurata, T.Abe, Y.Fukumoto:Clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues by FDG-PET/CT, Journal of Clinical Endocrinology & Metabolism,
100:5;E739-E747, 2015.
7200B013 M.Takeuchi, J.Takino, H.Shirai, M.Kawakami, S.Furuno, Y.Kobayashi:Assessment of total sugar and glucose concentrations in commonly consumed beverages in Japan, Nutrition and Food Technology:Open Access, 1:2;1-9,
2015.
7200B014 M.Takeuchi, J.Takino, S.Furuno, H.Shirai, M.Kawakami, M.Muramatsu, Y.Kobayashi, S.Yamagishi:Assessment of the concentrations of various advanced glycation end-products in beverages and foods that are commonly
consumed in Japan, PLoS One, 10:3;e0118652, 2015.
103 7200B015 (M.Takeda), T.Ohnuma, M.Takeuchi, N.Katsuta, H.Maeshima, Y.Takebayashi, M.Higa, T.Nakamura, S.Nishimon, T.Sannohe, Y.Hotta, R.Hanzawa, R.Higashiyama, N.Shibata, T.Gohda, Y.Suzuki, S.Yamagishi, Y.Tomino, H.Arai:Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor
levels indicate carbonyl stress in patients with schizophrenia, Neuroscience Letters, 593:51-55, 2015.
7200B016 M.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.Okazaki:Lysososomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in
natural killer/T lymphoma cell apoptosis, Cell Death and Disease, 6:e1717;1-12, 2015.
7200B017 (H.Yazama), K.Kitatani, K.Fujiwara, M.Kato, M.Hashimoto-Nishimura, K.Kawamoto, K.Hasegawa, H.Kitano, A.Beilawska, J.Bielawski, T.Okazaki:Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide,
International Journal Clinical Oncology, 20:3;438-446, 2015.
7200B018 (A.Okumura), M.Ozaki, Y.Niida:Development of a practical NF1 genetic testing method through the pilot analysis
of five Japanese families with neurofibromatosis type 1., Brain & Development, 37:7;677-689, 2015.
7200B019 H.Ogiso, M.Taniguchi, T.Okazaki:Analysis of lipid-composition changes in plasma membrane microdomains,
Journal of Lipid Research, 56:8;1594-1605, 2015.
7200B020 Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, Y.Motoo, K.Miyazawa:Initial experience of enzalutamide in patients with castration resisitant prostate cancer, Journal of
Kanazawa Medical University, 40:2・3;196-200, 2015.
Reviews 7200C001 Y.Niida:Development and Clinical Application of Mutation Screening Method “CHIPS”, Journal of Kanazawa
Medical University, 40:2・3;84-91, 2015.
7200C002 M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda :Involvement of toxic AGEs(TAGE) in the onset/deterioration of lifestyle-related diseases -New preventive strategy-:-Toxic truth about dietary AGEs and
sugars-, Journal of Kanazawa Medical University, 40:95-103, 2015.
7200C003 Y.Motoo:Gender difference in clinical practice for cancer patients, Japanese Journal of Clinical Medicine,
73:4;666-670, 2015.
7200C004 (K.Kitatani), M.Taniguchi, T.Okazaki:Role of sphingolipids and metabolizing enzymes in hematological
malignancies, Molecules and Cells, 38:6;482-495, 2015.
7200C005 M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi:Toxic AGEs (TAGE) theory in the
pathogenesis of NAFLD and ALD, International Journal of Diabetes and Clinical Researsh, 2:4;1-5, 2015.
7200C006 (J.Takino), K.Nagamine, T.Hori, A.Sakasai-Sakai, M.Takeuchi:Contribution of the toxic advanced glycation end- products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma, World Journal of
Hepatology, 7:23;2459-2469, 2015.
Case Reports 7200D001 (N.Hatta), A.Takata, S.Ishizawa, Y.Niida:Family with MSH2 mutation presenting with keratoacanthoma and
precancerous skin lesions, Journal of Dermatology, 42:11;1087-1090, 2015.
7200D002 J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi:Effective treatment with Kampo medicines of
fibromyalgia that occurred after the mycoplasma infection, PAIN AND KAMPO MEDICINE, 25:129-133, 2015.
7200D003 Y.Niida, M.Ozaki, E.Takase, T.Yokoyama, S.Yamada:A girl with greig cephalopolysyndactyly contiguous gene
deletion syndrome: The importance and usefulness of DNA microarray analysis, Hereditary Genetics, S7:1-3, 2015.
7200D004 Y.Niida:Radiological diagnosis of a neonate with mucolipidosis II (I-cell disease), Clinical Medical Image Library,
1:2;17-18, 2015.
104 Short Communications 7200E001 M.Takeuchi, A.Sakasai-Sakai, T.Takata, T.Ueda, J.Takino, M.Tsutsumi, H.Hyogo, S.Yamagishi:Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH., Medical
Hypotheses, 84:490-493, 2015.
7200E002 Y.Niida, O.Ozaki, M.Inoue, E.Takase, M.Kuroda, Y.Mitani, A.Okumura, A.Yokoi, S.Fujita, K.Yamada:CHIPS for
genetic testing to improve a regional clinical genetic service, Clinical Genetics, 88:2;155-160, 2015.
7200E003 Y.Niida:How do you analyze a mutation of the gene consisting of one hundred exons?, Advanced Techniques in
Biology & Medicine, 3:3;138, 2015.
7200E004 Y.Niida:CHIPS to disseminate the genetic testing of rare diseases, Gene Technology, 4:3;127-127, 2015.
7200E005 Y.Niida:Finding gene mutations by the enzyme: Chips for a simple and highly sensitive enzyme mismatch cleavage
method, Enzyme Engineering, 4:2;131, 2015.
7200E006 Y.Niida:CHIPS for a mutation screening of a large sized gene: An example of NF2 analysis, Pharmaceutia Analytica
Acta, 6:11;440, 2015.
Others 7200F001 A.Sakasai-Sakai, M.Jinno, M.Takeuchi:Usefulness of toxic AGEs (TAGE) as a biomarker for fertility treatment,
Meeting of the Japan Mibyou System Association, 21:1;93, 2015.
7200F002 Y.Motoo:Description of Kampo medicines in the clinical practice guidelines for irritable bowel syndrome, Journal of
Gastroenterology, 50:7;816, 2015.
7200F003 M.Takauchim, J.Takino, S.Furuno, H.Shirai, M.Kawakami, M.Muramatsu, Y.Kobayashi:Pitfalls regarding today's eating habits;Truth about AGEs in foods and drinks and their glucotoxicity, Meeting of the Japan Mibyou System
Association, 22:130, 2015.
Presentations at Conference
International Conference (Key Note Lecture) 7200G001 T.Okazaki:Role of membrane lipids, sphingomyelin and ceramide in tumor cell growthi, migration and death.,
Cancer science institute of singapore, Singapore, 2015.
International Conference (Synposium) 7200H001 Y.Motoo:Evidence Reports on Kampo Treatment (EKAT) and Kampo medicines in clinical practice guidelines
(KCPG), The 10th International Congress of Complementary Medicine Research - ICCMR 2015, Jeju, 2015.
7200H002 Y.Motoo,I.Arai,K.Tsutani:Systematic review on the use of Kampo diagnosis in randomized controlled trials of
Kampo medicines, 3rd International Symposium for Japanese Kampo Medicine (ISJKM), Vienna, 2015.
International Conference (Presentations) 7200I001 T.Okazaki, L.O.Waedhani, M.Hashimoto, K.Kitatani, H.Ogiso, Y.Ueda, M.Taniguchi:Enhancement of infiltration of malignant lymphoma cells in the mouse liver by sphingomyelin deficiency through sphingomyelin synthase2 (SMS2),
56th International Conference on the Bioscience of lipids, Puerto Iguzu, 2015.
105 7310 Division of Innovative Research
Faculty
Title Name Field of Specialization Professor(Additional Post) YONEKURA Hideto Molecular mechanisms of angiogenesis, Alternative mRNA processing Associate Environmental epidemiology, Enviromental health sciences, NISHIJO Muneko Professor(Additional Post) Epidemiology of cadmium pollution
Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants, neurovirology, Cancer chemoprevention by natural products,
Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. Cellular and molecular mechanisms in angiogenesis
Publications
Originals 7310B001 E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.
7310B002 PT.Tai, M.Nishijo, NTN.Anh, TN.Nghi, HV.Luong, TH.Anh, VT.Nguyen, H.Nishijo:Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at 1 year of age, Science of the Total Environment, 536:575-581,
2015.
7310B003 M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido, H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.
7310B004 (K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice for
renal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.
7310B005 (HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo, H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.
7310B006 TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa, T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.
7310B007 S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015.
106 7310B008 M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using a mixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.
7310B009 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.
7310B010 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause mortality increased by environmental cadmium exposure in the Japanese general population in cadmium non-
polluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.
Reviews 7310C001 (C.Chen),P.Xun, M.Nishijo, A.Sekikawa, K.He:Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case-control studies among individuals without occupational exposure history,
Environmental Science and Pollution Research, 22:22;17465-17474, 2015.
Presentations at Conference
International Conference (Synposium) 7310H001 M.Nishijo:History of Cd pollution and health effect., A Symposium on Health Effects among Cadmium Exposed
Inhabitants in Mae Sot District,Tak Province,Thailand, Mae Sot Thailand, 2015.
7310H002 M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in the Cadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.
International Conference (Presentations) 7310I001 (TT.Pham),M.Nishijo,MT.Do,NT.Pham,VL.Hoang,HA.Tran,VL.Nguyen,NN.Tran,VK.Tran,TT.Dang,TL.Nguyen,H. Nishijo,H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium on Halogenated
Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.
7310I002 TN.Nghi, PT.Tai, PN.Thao, M.Nishijo:Dioxin concentration in breast milk and umbilical cord blood samples of mother-baby pairs living near Bien Hoa Airport., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vientnam, Hanoi, 2015.
7310I003 M.Nishijo,TN.Nghi,PN.Thao,PT.Tai,AH.Tran,HV.Luong,H.Nishijo:Dioxin effects on groeth and neurodevelopment of infants and children in Vietnam., International workshop on the harmful effects of Agent Orange/Dioxin on the
environment and human health of Vietnam, Hanoi, 2015.
7310I004 H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.
107 7320 Division of Vision Research for Environmental Health
Faculty
Title Name Field of Specialization Professor(Additional Post) SASAKI Hiroshi cataract, epidemiology, uveitis cataract, ophthalmological optics, electromagnetic ocular injury, Professor(Additional Post) KOJIMA Masami epidemiolgy Assistant HATSUSAKA Natsuko ophthalmological optics Professor(Additional Post)
Keywords of Research
electromagnetic waves, ultraviolet rays, radioactive rays, cataract, pterygium, pinguecula.
Outline of Research
This research division studies environmental effects on incidence of ocular diseases. In quantitative studies of radio frequency (RF) electromagnetic spectrum effects on eyes, ocular effects from exposure to wavelengths encountered in daily life are examined by experimentation on rabbit eyes. Research on ocular exposure to ultraviolet (UV) wavelengths utilizes a human like mannequin equipped with UV sensors, and evaluates the efficacy of sunglasses, eye glasses and other accessories in offering eye protection against harmful exposure. Our longitudinal epidemiological studies on eyes in Japan (Ishikawa) and Iceland, epidemiological surveys on blindness and UV-related eye disease in Tanzania, and ocular epidemiological studies in domestic and international regions with different climate conditions were conducted to investigate and analyze associations among ocular UV exposure and cataract, pterygium, and pinguecula. In our epidemiological study on UV-related ocular diseases targeting Japanese and Taiwanese children, the effects of ocular UV exposure in childhood are examined. In 2013, a longitudinal study on radiation exposure dose and incidence of lens opacity in emergency workers of TEPCO Fukushima Daiichi Nuclear Power Plant was commenced and is envisaged to include approximately 20,000 subjects.
Publications
Originals 7320B001 M.Fukuda, H.Sasaki:The transcorneal penetration of commercial ophthalmic formulations containing timolol
maleate in rabbit eyes, Journal of Ocular Pharmacology and Therapeutics, 31:1;57-60, 2015.
7320B002 (H.Maeda), T.Takata, N.Fujii, H.Sakaue, S.Nirasawa, S.Takahashi, H.Sasaki, N.Fujii:Rapid survey of four asp isomers in disease-related proteins by LC-MS combined with commercial enzymes, Analytical Chemistry, 87:561-
568, 2015.
7320B003 M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki:Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40
GHz), Journal of Infrared Millimeter and Terahertz Waves, 36:4;390-399, 2015.
7320B004 S.Enta, N.Hatsusaka, Y.Sakamoto, N.Mita, M.Takahashi, H.Osada, E.Kubo, H.Sasaki:Visual acuity and contrast visual acuity predicted from cataract type, The Journal of the Japanese Society for Cataract Research, 27:68-73,
2015.
180B005 (K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto:Dielectric property measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, Physics in Medicine and Biology,
60:6273-6288, 2015.
7320B006 M.Fukuda, H.Sasak:Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing,
Journal of Ocular Pharmacology and Therapeutics, 31:9;536-540, 2015.
108 7320B007 Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki:Optical simulation for
subsurface nanoglistening, Journal of Cataract and Refractive Surgery, 41:193-198, 2015.
Reviews 7320C001 (K.Minami), K.Miyata, N.Nagai, H.Sasaki:Use of a warmed ophthalmic viscoelastic device to accelerate the unfolding of 1-piece intraocular lenses in the capsular bag, Journal of Cataract & Refractive surgery, 41:2332-
2333, 2015.
7320C002 (Y.Suzuki), M.Taki, M.Kojima:Dosimetry on high-frequency electromagnetic field exposure with micro-
encapsulated thermo-chromic liquid crystal, IEICE technical report, 1-6, 2015.
7320C003 H.Sasaki:Update no multifocal intraocular lenses' development, Journal of Japanese Ophthalmological Society,
119:1;3-5, 2015.
Presentations at Conference
International Conference (Presentations)
7320I001 H.Sasaki:Standardized classifications and severity scales of cataract , Asia Arvo, Yokohama, 2015.
7320I002 (Y.Suzuki), M.Sasaki, S.Onishi, R.Imai, M.Takamura, M.Taki, J.Chakarothai, K.Sasaki, K.Wake, S.Watanabe, M.Kojima, CY,Tsai, H.Sasaki:Acceleration of large-scale multi-physics simulation for biomedical EMC with many-
core architecture based computing, URSI AT-RASC, Canary Istands, 2015.
7320I003 H.Sasaki, E.Shibuya, M.Takahashi, A.Okamoto, N.Mita, N.Hatsusaka, S.Shibata, T.Shibata, K.Sasaki, E.Kubo:Effect of forward light scattering on visual function in eyes with cortical cataract, Association for Research
in Vision and Ophthalology, Denver, 2015.
7320I004 T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:FGF-2 regression of the tropomyosin expression through MAPK/ERK kinase pathway in lens epithelial cells, Association for Research in Vision and
Ophthalology, Denver, 2015.
7320I005 E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expression profiling of lens epithelial cells in a rat posterior capsular opacity model in vivo, Association for Research in Vision and
Ophthalology, Denver, 2015.
7320I006 Y.Seki, T.Shibata, Y.Yabata, M.Sasaki, H.Osada, T.Saruta, H.Asano, E.Kubo, A.Sanyiwa, H.Sasaki:Prevalence of
pinguecula in children living in rural Tanzania, Association for Research in Vision and Ophthalology, Denver, 2015.
7320I007 H.Sasaki, E.Shibuya, M.Takahashi, N.Shibata, Y.Takahashi, S.Shibata, T.Shibata, N.Mita, E.Kubo:Effect of forward
light scattering on visual function in eyes with retrodots, XXXIII Congress of the RSCRS, Barcelona, 2015.
7320I008 (Y.Suzuki), M.Kojima, A.Kik, M.Taki:Non-destructive 3D temperature measurement for dosimetries of the thermal dose due to high frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal,
First PEM International Workshop in Kyoto, Kyoto, 2015.
7320I009 E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expressin profiling of lens epithelial cells in posterior capsular opacity and the role of decorin, The 3rd International Conference on the Lens
2015, Kona, 2015.
7320I010 N.Mita, M.Sasaki, Y.Takahashi, Y.Seki, A.Okamoto, T.Shibata, S.Shibata, E.Kubo, H.Sasaki:Higher-order aberrations in Japanese eyes with cataract and eyes with aspherical intraocular lenses, The 3rd International
Conference on the Lens 2015, Kona, 2015.
7320I011 S.Shibata, N.Shibata, T.Shibata, N.Tanimura, H.Sasaki, E.Kubo:Human age related cataract and decorin: correlations among opacity severity, age and decorin expression, The 3rd International Conference on the Lens
2015, Kona, 2015.
7320I012 H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.
109 7320I013 E.Shibuya, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, T.Shibata, E.Kubo, H.Sasaki:Influence on visual function by high-order aberration, forward and backward light scattering in eyes with nuclear opacity, The 3rd International
Conference on the Lens 2015, Kona, 2015.
7320I014 N.Hatsusaka, H.Osada, E.Shibuya, A.Okamoto, M.Sasaki, M.Takahashi, A.Nakano, Y.Seki, E.Kubo, H.Sasaki:Lenticular findings in emergency workers at Tokyo Electric Power Fukushima Nuclear Power Plant at 4
years post-exposure, The 3rd International Conference on the Lens 2015, Kona, 2015.
7320I015 H.Sasaki, H.Asano, T.Hiraoka, H.Osada, T.Shibata, M.Sasaki, Y.Seki, T.Saruta, F.Fujikake, Y.Tabata, T.Oshika, A.Sanyiwa:Mopia and related factors in Tanzanian adults, The 3rd International Conference on the Lens 2015,
Kona, 2015.
7320I016 T.Shibata, S.Shibata, H.Sasaki, DP.Singh, E.Kiyokawa, M.Ikawa, E.Kubo:Suppression of injury-induced epithelial- mesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9, The 3rd International
Conference on the Lens 2015, Kona, 2015.
110 7340 Division of Anticipatory Molecular Food Science and Technology
Faculty
Title Name Field of Specialization Professor(Additional Post) KOYA Daisuke diabetes, hypertension, obesity, aging Associate KANASAKI Keizo diabetes, hypertenstion, obesity, preeclampsia Professor(Additional Post) Associate KITADA Munehiro diabetes, diabetical renal disease, hypertension Professor(Additional Post)
Publications
Originals 7340B001 (M.Yasuda-Yamahara), S.Kume, K.Yamahara, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya, M.Haneda, S.Ugi, H.Maegawa, T.Uzu:Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via
enhancing energy expenditure, Biochemical and Biophysical Research Communications, 465:2;249-255, 2015.
7340B002 S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya:Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney International., 88:3;479-489,
2015.
7340B003 (S.Araki), M.Haneda, D.Koya, K.Kondo, S.Tanaka, H.Arima, S.Kume, J.Nakazawa, M.Chin-Kanasaki, S.Ugi, H.Kawai, H.Arai, T.Uzu, H.Maegawa:Urinary potassium excretion and renal and cardiovascular complications in patients with type 2 diabetes and normal renal function, Clinical journal of the American Society of Nephrology : CJASN., 10:12;2152-2158, 2015.
7340B004 (S.Kato), S.Maruyama, H.Makino, J.Wada, D.Ogawa, T.Uzu, H.Araki, D.Koya, K.Kanasaki, Y.Oiso, M.Goto, A.Nishiyama, H.Kobori, E.Imai, M.Ando, S.Matsuo:Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial, Clinical and Experimental Nephrology, 19:6;1098-
1106, 2015.
7340B005 (Y.Tanaka), S.Kume, H.Araki, J.Nakazawa, M.Chin-Kanasaki, S.Araki, F.Nakagawa, D.Koya, M.Haneda, H.Maegawa, T.Uzu:1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney
proximal tubular cell, Free Radical Biology & Medicine., 89:831-841, 2015.
Reviews 7340C001 T.Nagai, K.Nitta, M.Kanasaki, D.Koya, K.Kanasaki:The biological significance of angiotensin-converting enzyme
inhibition to combat kidney fibrosis, Clinical and Experimental Nephrology, 19:1;65-74, 2015.
7340C002 (M.Haneda), K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino, K.Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda, K.Ichikawa, K.Shide:A new classification of diabetic nephropathy 2014: a report from joint committee on diabetic nephropathy, Journal of Diabetes
Investigation, 6:2;242-246, 2015.
7340C003 N.Ueki, S.Takeda, D.Koya, K.Kanasaki:The relevance of the renin-angiotensin system in the development of drugs
to combat preeclampsia, International Journal of Endocrinology [Electronic Resource], 2015:572713;1-12, 2015.
7340C004 Kidney fibrosis and endothelial injury, The japanese journal of Nephrology, 57:7;1200-1205, 2015.
7340C005 K.Nitta, M.kanasaki, K.Kanasaki, D.koya:The role of angiotensin-converting enzyme inhibition to cimbat kidney
fibrosis, Journal of Kanazawa Medical University, 40:2・3;131-138, 2015.
7340C006 Diagnosis and management of diabetic nephropathy, Nihon Rinsyo, 73:12;2037-2043, 2015.
111 7340C007 (S.Kume), D.Koya:Autophagy: A novel therapeutic target for diabetic nephropathy, Diabetes & Metabolism
Journal., 39:3;451-460, 2015.
Case Reports 7340D001 Y.Sasagawa, O.Tachibana, A.Nakagawa, D.Koya, H.Iizuka:Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma, Journal of Clinical Neuroscience,
22:3;601-603, 2015.
Short Communications 7340E001 D.Koya:Epidermal growth factor receptor signaling and the progression of diabetic nephropathy, Journal of
Diabetes Investigation, 6:5;519-521, 2015.
Presentations at Conference
International Conference (Synposium) 7340H001 D.Koya:S21 Diabetic complications The role of autophagy in diabetic nephropathy, The Korean Society for
Biochemistry and Molecular Biology International Conference 2015, Seoul, 2015.
7340H002 D.Koya:Symposium12 Diverse cell signaling in metabolic syndrome High fat diet-induced hepatosteatosis was ameliorated by the treatment with ketogeic amino acid, 2015 International Congress on Obesity and Metabolic
Syndrome in conjunction with the 43rd Annual Scientific Meeting of KSSO, Seoul, 2015.
International Conference (Presentations) 7340I001 K.Kanasaki, S.Shi, M.Kanasaki, D.Koya:The interaction between DPP-4 and intergrin β1 regulates the signaling responsible for induction of the endothelial to mesenchymal transition in diabetic kidney, American Diabetes
Association 74th Scientific Sessions, Boston, 2015.
7340I002 K.Kanasaki, S.Shi, M.Kanasaki, D.Koya:The interaction between DPP-4 and intergrin β1 regulates the signaling responsible for induction of the endothelial to mesenchymal transition in diabetic kidney, American Diabetes
Association 74th Scientific Sessions, Boston, MA, USA, 2015.
112 7350 Division of Systems Bioscience for Drug Discovery Based on Intrinsically Disordered Proteins
Faculty
Title Name Field of Specialization Professor(Additional Post) TOMOSUGI Naohisa Clinical Proteomics Professor(Additional Post) ISHIGAKI Yasuhito Molecular and Cellular Biology Associate SHIMASAKI Takeo Medical Oncology, Gastroenterology, Bioinformatics Professor(Additional Post)
Books
7350A001 T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.
Publications
Originals 7350B001 Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.
7350B002 J.Zhang, Y.Ishigaki, T.Takegami:Hepatitis C virus NS3 protein modulates the biological behaviors of malignant
hepatocytes by altering the expression of host cell microRNA, Molecular Medicine Reports, 12:4;5109-5115, 2015.
7350B003 Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.
7350B004 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.
7350B005 J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.
7350B006 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.
7350B007 F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.
7350B008 Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.
113
Reviews 7350C001 (K.Tazaki), M.Nakano, T.Takehara, Y.Ishigaki, H.Nakagawa:Experimental analysis of plastic materials containing
radionuclides for decontamination viability, 69:2;99-108, 2015.
7350C002 Y.Nakmaura, T.Tatsuno, Y.Ishigaki:Scanning electron microscopy observation with ionic liquid, Journal of
Kanazawa Medical University, 40:2,3;125-130, 2015.
Short Communications 7350E001 (H.Yoshida), Y.Ishigaki, A.Takizawa, K.Moro, Y.Kishi, T.Takahashi, H.Matsui:Comparative genomics of the mucoid and nonmucoid strains of streptococcus pyogenes, isolated from the same patient with streptococcal
meningitis, 3:2;e00221-15, 2015.
Presentations at Conference
International Conference (Presentations) 7350I001 X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.
114 7400 Research Support Center
Faculty
Title Name Field of Specialization Professor(Additional Post) ISHIGAKI Yasuhito Molecular and Cellular Biology Epidemiology of cardiovascular diseases, occupational medicine, Professor(Additional Post) NAKAGAWA Hideaki preventive medicine Professor(Additional Post) NAKAMURA Akira Immunology Senior Assistant Pathogenicity of flavivirus isolated from the field-collected MURAKAMI Manabu Professor(Additional Post) mosquitoes
Books
7400A001 T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.
Publications
Originals 7400B001 Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.
7400B002 J.Zhang, Y.Ishigaki, T.Takegami:Hepatitis C virus NS3 protein modulates the biological behaviors of malignant
hepatocytes by altering the expression of host cell microRNA, Molecular Medicine Reports, 12:4;5109-5115, 2015.
7400B003 K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.
7400B004 (D.Sugiyama), T.Okamura, M.Watanabe, A.Higashiyama, N.Okuda, Y.Nakamura, A.Hozawa, Y.Kita, A.Kadota, Y.Murakami, N.Miyamatsu, T.Ohkubo, T.Hayakawa, Y.Miyamoto, K.Miura, A.Okayama, H.Ueshima; NIPPON DATA 80/90 Research Group.:Risk of hypercholesterolemia for cardiovascular disease and the population attributable fraction in a 25-year Japanese cohort study, Journal of Atherosclerosis and Thrombosis, 22:1;95-107,
2015.
7400B005 M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido, H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.
7400B006 (K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice for
renal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.
7400B007 Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.
7400B008 (M.Satoh), T.Ohkubo, K.Asayama, Y.Murakami, M.Sakurai, H.Nakagawa, H.Iso, A.Okayama, K.Miura, Y.Imai, H.Ueshima, T.Okamura; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH?JAPAN) Research Group:Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: Evidence for cardiovascular prevention from observational cohorts in
Japan., Hypertension, 65:3;517-524, 2015.
7400B009 (T.Hisamatsu), K.Miura, A.Fujiyoshi, T.Okamura, T.Ohkubo, SY.Nagasawa, M.Horie, A.Okayama, H.Ueshima; NIPPON DATA80 Research Group:Long-term outcomes associated with prolonged PR interval in the general
Japanese population, International Journal of Cardiology, 184:291-293, 2015.
115 7400B010 (HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo, H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.
7400B011 (N.Okuda), K.Miura, A.Okayama, T.Okamura, RD.Abbott, N.Nishi, A.Fujiyoshi, Y.Kita, Y.Nakamura, N.Miyagawa, T.Hayakawa, T.Ohkubo, Y.Kiyohara , H.Ueshima; NIPPON DATA80 Research Group.:Fruit and vegetable intake and mortality from cardiovascular disease in Japan: a 24-year follow-up of the NIPPON DATA80 Study., European
Journal of Clinical Nutrition, 69:4;482-488, 2015.
7400B012 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.
7400B013 J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.
7400B014 A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral blood
mononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015. 7400B015 (A.Misawa), K.Yoshita, T.Fukumura, T.Tanaka, J.Tamaki, T.Takebayashi, Y.Kusaka, H.Nakagawa, H.Yamato, A.Okayama, K.Miura, T.Okamura, H.Ueshima, HIPOP-OHP Research Group:Effects of long-term intervention in
a work cafeteria on employee vegetable intake, Journal of occupational health, 57:3;97-107, 2015.
7400B016 TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa, T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.
7400B017 F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.
7400B018 M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using a mixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.
7400B019 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.
7400B020 (IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination for
survival data, Biometrical Journal, 57:4;592-613, 2015.
7400B021 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause mortality increased by environmental cadmium exposure in the Japanese general population in cadmium non-
polluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.
7400B022 Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.
7400B023 (K.Nakamura), H.Nakagawa, Y.Murakami, A.Kitamura, M.Kiyama, K.Sakata, I.Tsuji, K.Miura, H.Ueshima, T.Okamura; EPOCH?JAPAN research group.:Smoking increases the risk of all-cause and cardiovascular mortality
in patients with chronic kidney disease, Kidney International., 88:5;1144-1152, 2015.
116 7400B024 (M.Nagai), T.Ohkubo, Y.Murakami, N.Takashima, A.Kadota, N.Miyagawa, Y.Saito,N.Nishi, N.Okuda, Y.Kiyohara, H.Nakagawa, Y.Nakamura, A.Fujiyoshi, RD.Abbott,T.Okamura, A.Okayama, H.Ueshima, K.Miura.:Secular trends of the impact of overweight and obesity on hypertension in Japan, 1980-2011, Hypertension Research, 38:11;790-
795, 2015.
Reviews 7400C001 (K.Tazaki), M.Nakano, T.Takehara, Y.Ishigaki, H.Nakagawa:Experimental analysis of plastic materials containing
radionuclides for decontamination viability, 69:2;99-108, 2015.
7400C002 (K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.
7400C003 Y.Nakmaura, T.Tatsuno, Y.Ishigaki:Scanning electron microscopy observation with ionic liquid, Journal of
Kanazawa Medical University, 40:2,3;125-130, 2015.
Short Communications 7400E001 (H.Yoshida), Y.Ishigaki, A.Takizawa, K.Moro, Y.Kishi, T.Takahashi, H.Matsui:Comparative genomics of the mucoid and nonmucoid strains of streptococcus pyogenes, isolated from the same patient with streptococcal
meningitis, 3:2;e00221-15, 2015.
Presentations at Conference
International Conference (Synposium) 7400H001 M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in the Cadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.
International Conference (Presentations) 7400I001 SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.
7400I002 Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd
International Symposium on Shiftwork and Working Time, Elsinore, 2015.
7400I003 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
7400I004 X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.
7400I005 (TT.Pham),M.Nishijo,MT.Do,NT.Pham,VL.Hoang,HA.Tran,VL.Nguyen,NN.Tran,VK.Tran,TT.Dang,TL.Nguyen,H. Nishijo,H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium on Halogenated
Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.
117 School of Nursing 8010 Fundamental Nursing
Faculty
Title Name Field of Specialization Professor SAKAI Keiko Nursing history, Nursing skills Professor TAKIUTI Takako Nursing history, Nursing skill Associate Professor MATSUI Yuko Nursing skill Senior Assistant Professor SUGIMORI Chiyoko Nursing skill Assistant Professor OKAYAMA Miki Patient education for diabetes
Keywords of Research
fundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care
Outline of Research
1. Verification of nursing skills 2. Study of nursing education
Publications
Originals 8010B001 A.Kumagai, M.Heinai, Y.Matsui, C.Konya, K.Shimada, S.Kawakami, J.Sugama:Effectiveness of highly resilient urethane foam mattresses in pressure ulcerprevention for special operative positions, Japanese journal of pressure
ulcer, 17:1;1-9, 2015.
Presentations at Conference
International Conference (Presentations) 8010I001 S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Factors related to catheter blockage in home
nursing care patients with long-term indwelling catheters, 16th international EAUN meeting, Madrid, 2015.
118 8085I004 M.Hasegawa:An Intervention of Depression and Suicidal Behavior Patients With Emotion Modulation
Therapy(EMT), ACMHN’s 41st International Mental Health Nursing Conference 2015, Brisbane, 2015.
119 8040 Maternity Nursing・Midwifery
Faculty
Title Name Field of Specialization YANAGIHARA Professor Matenity Nursing，Midwifery Machiko Senior Assistant Professor BODA Hitomi Matenity Nursing，Midwifery Senior Assistant Professor IWATANI Kumiko Matenity Nursing，Midwifery Assistant Professor YAMAZAKI Chisato Maternity Nursing
Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care
Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.
Publications
Originals 8040B001 K.Iwatani, Y.Kiyosuke, H.Mori:Background factors causing difficulty of raising children by first-time mothers that public health nurses and midwines have sensed: a report by performing home visiting services for infants, Maternal
health, 56:2;383-390, 2015.
Presentations at Conference
International Conference (Presentations) 8040I001 K.Iwatani,C.Yamazaki,T.Tamura,K.Shimada:Teaching activities for safety management in midwifery training,
ICMAPRC, Yokohama, 2015.
120 8050 Pediatric Nursing
Faculty
Title Name Field of Specialization Senior Assistant Professor HASHI Shinobu Single mother, asthma, child, belief, parenting stress Prevention of Maltreatment, Family Nursing in Child＆Maternal Assistant Professor TERAI Takahiro Health Care
Keywords of Research
school children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's problem-solving ability, intervention program for families, maltreatment, abuse, assessment,
Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental disorder (FPAYCDD) 2.Study of the efficacy of a support program for families with a young child with a developmental disorder 3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children 4.Study of the system for carrying out abuse prevention
Presentations at Conference
International Conference (Presentations) 8050I001 S.Hashi:Single Mothers who have Children with Asthma in Japan, The 6th International Conference on Community
Health Nursing Research, Seoul, 2015.
121 8060 Adult Nursing
Faculty
Title Name Field of Specialization Professor KONYA Chizuko Wound Care, Stoma care, Continence care Associate Professor MURAKADO Naoko Chronic nursing，Diabetes nursing Senior Assistant Professor KINOSHITA Sachiko Wound Care, Stoma care, Continence care Senior Assistant Professor KITAMURA Yoshiko Cancer Nursing Assistant Professor ASANO Kimi Wound Care Assistant Professor Natsuko Yamada Critical Care
Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care
Outline of Research
Clinical Medical-Surgical Nursing.
Publications
Originals 8060B001 Y.Miyawaki, Y.Shimizu, K.Uchiumi, K.Asou, N.Murakado, K.Kuroda, H.Masaki, M.Seto, H.Ishii:Reliability and Validity of a Shortened Version of an Instrument for Diabetes Self-Care Agency, Journal of Nursing Measurement, 23:2;326-335, 2015.
8060B002 A.Kumagai, M.Heinai, Y.Matsui, C.Konya, K.Shimada, S.Kawakami, J.Sugama:Effectiveness of highly resilient urethane foam mattresses in pressure ulcerprevention for special operative positions, Japanese journal of pressure
ulcer, 17:1;1-9, 2015.
8060B003 C.Konya, J.Sugama, H.Alozuki, H.Sanada:Effectiveness of a non-invasive pressure ulcer undermining measuring
device, 2:2;99-106, 2015.
8060B004 (K.Mukai), E.Komatsu, T.Urai, Y.Nakajima, K.Asano, N.Ozaki, T.Nakatani:Anatomical investigation of position of crossing of superficial branch of radial nerve and cephalic vein and its frequency, Structure and Function, 14:1;3-
11, 2015.
122 8070 Gerontological Nursing
Faculty
Title Name Field of Specialization Professor HIRAMATSU Tomoko community/elderly nursing science Associate Professor KOIZUMI Yumi community/elderly nursing science Assistant Professor HASHIMOTO Tomoe community/elderly nursing science
Keywords of Research
gerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in the community, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care
Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women, etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、 Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on “Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot care for the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker
Publications
Originals 8070B001 (M.shogenji), C.Yuno, H.Nakada, H.Shimode, C.Sakakibara, T.Hiramatsu:Continence care can prevent urinary tract infections among elderly patients by reducing the duration of indwelling urinary catheter use, Journal of
Japanese Society of Wound, Ostomy and Continence Management, 19:3;336-345, 2015.
123 8080 Public Health Nursing
Faculty
Title Name Field of Specialization Professor NAKASHIMA Motoko public health nursing School hygiene Industrial health Associate Professor HAMAZAKI Yuko public health nursing, study of elder abuse Associate Professor SAKURAI Shihomi public health nursing, Family nursing Assistant Professor Tonoyama Noriko public health nursing
Keywords of Research
Public health nursing-care activity, Public health nursing education, Health promotion, activity of cmmunity organization, Non-smoking education, School hygiene, Industrial health,
Outline of Research
The Public Health nursing study field aims at the science-of-nursing research which can contribute to improvement in the residents of the area, especially the quality of a life of people with health disturbance, part of a drug abuse prevention program for junior high school student and health maintenance.
Publications
Originals 8080B001 S.Sakurai, J.Onishi, M.Hirai:Impaired autonomic nervous system activity during sleep in family caregivers of
ambulatory dementia patients in Japan, Biological research for nursing, 17:1;21-28, 2015.
8080B002 T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda, S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.
Presentations at Conference
International Conference (Presentations) 8080I001 Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd
International Symposium on Shiftwork and Working Time, Elsinore, 2015.
8080I002 S.Sakurai, Y.Kohno, N.Sakurai, A.Maekawa, M.Hirai:Effects of stress on blood pressure in Japanese family
caregivers of the frail elderly, International collaboration for community health nursing research 2015, Seoul, 2015.
124 8085 Psychiatric and Mental Health Nursing
Faculty
Title Name Field of Specialization depression, suicide prevention, therapeutic nursing, narrative Professor HASEGAWA Masami approach life-world led care, patient-nurse interrelationship, empathy, Senior Assistant Professor TANAKA Koji psychiatric and mental health nursing Minimization for the action limitation, psychiatric nursing for acute Senior Assistant Professor NAGAYAMA Yutaka phase
Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship, empathy, psychiatric and mental health nursing, minimizing for the action limitation, physical restraint, seclusion, Emotion Modulation Therapy
Outline of Research
The purpose of our study is to clarify the suicide prevention effect for the depression people by Narrative approach and Emotion Modulation Therapy(EMT). We are trｙing the effect of these methods as new therapeutic nursing for depression people between our nursing clinic in Japan and Griffth University clinic in Australia.
Publications
Originals 8085B001 K.Tanaka, T.Yoshino, M.Hasegawa, Y.Nagayama, M.Oe:Empathy experienced by psychiatric nurses through the
patient-nurse relationship, Journal of Japan Academy of Nursing Science, 35:184-193, 2015.
8085B002 (K.Kawamura), M.Hasegawa :Change of the recognition about prevention for depression through participation in alcoholics anonymous meetings for women alcoholics, The Japan Academy of Psychiatric and Mental Health
Nursing, 24:1;51-58, 2015.
8085B003 (S.Ohe), M.Hasegawa:Interactions and attitude of nurses who have suffered physical and verbal
abuse from children with Asperger’s disorder, Journal of Society od Nursing Practice, 28:1;1-8, 2015.
Presentations at Conference
International Conference (Presentations) 8085I001 Y.Nagayama, A.Fukutsuka, K.Ikuno, R.Kaneda, Y.Kawasaki, M.Kitamura, Y.Minabe, T.Nagasawa, H.Nakade, M.Oe:Relationship between coercive measures and nursing interventions in university hospital psychiatric wards in
Japan, 17th Annual Conference of the International Society of Psychiatric-Mental Health Nurses, Seattle, 2015.
8085I002 M.Hasegawa,K.Nagata:A narrative intervention of depression and suicidal behavior patients with emotion modulation therapy(EMT), 17th Annual Conference of the International Society of Psychiatric-Mental Health
Nurses, Seattle, 2015.
8085I003 K.Tanaka, T.Yoshino:Structure of nursing activities for promoting resilience in patients with mental disorders, 17th
International Society of Psychiatric Mental Health Nurses, Seattle, 2015.
125 8090 Home Care Nursing
Faculty
Title Name Field of Specialization Professor MAEDA Shuko home care, home health care nurse home care nursing, home care nursing teaching method, discharge Senior Assistant Professor KOHNO Yumiko support Assistant Professor NAKAI Hisao Home healthcare,Disaster Nursing,Care Management Assistant Professor FUKUDA Moriyoshi Nursing care of pressure uler，Home care
Keywords of Research
home healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education, education program, Psychiatric Disorder, Community besed Workshop, Recoverry"consept
Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, where introduced Recoverry"consept prevent the exclusion and separation from the community as functioned of the psychatric service institution in the community. Practice and restructuring of the infection control edcation program for home visiting nurses
Publications
Originals 8090B001 H.Nakai:Recognition concerning social environments and supports of the frail elderly with medical care needs,
Journal of Japan Academy of Home Care, 19:1;74-81, 2015.
Presentations at Conference
International Conference (Presentations) 8090I001 S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Factors related to catheter blockage in home
nursing care patients with long-term indwelling catheters, 16th international EAUN meeting, Madrid, 2015.
8090I002 S.Sakurai, Y.Kohno, N.Sakurai, A.Maekawa, M.Hirai:Effects of stress on blood pressure in Japanese family
caregivers of the frail elderly, International collaboration for community health nursing research 2015, Seoul, 2015.
126 8100 Medical Science
Faculty
Title Name Field of Specialization Professor ISHIBASHI Takaharu Cardiovascular Pharmacology Professor IWAI Kunimitsu Geriatrics, Circulation, Cell Biology Professor KOHNO Hiroyuki Experimental Pathology, Tumor immunology Professor MORIKAWA Yuko Cardiovascular epidemiology, occupational medicine Study of Cataractogenesis mechanisms, Relation of the intraocular Professor KOJIMA Masami temperature during infrared exposure and environmental temperature Professor HONDA Ryumon Environment and health, Epidemiology
Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays exposure
Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing vasodilators. M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays) exposure. K. Iwai:Role of the nuclear matrix associated proteins in the regulation of gene expression of the cardiovascular cells.
Publications
Originals 8100B001 Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.
8100B002 K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.
8100B003 M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido, H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.
8100B004 T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio:Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes
to heat sensitivity., British Journal of Pharmacology, 172:4;1020-1033, 2015.
8100B005 M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki:Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40
GHz), Journal of Infrared Millimeter and Terahertz Waves, 36:4;390-399, 2015.
127 8100B006 M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using a mixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.
8100B007 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.
8100B008 (IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination for
survival data, Biometrical Journal, 57:4;592-613, 2015.
8100B009 (Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause mortality increased by environmental cadmium exposure in the Japanese general population in cadmium non-
polluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.
8100B010 (K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto:Dielectric property measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, Physics in Medicine and Biology,
60:6273-6288, 2015.
Reviews 8100C001 (Y.Suzuki), M.Taki, M.Kojima:Dosimetry on high-frequency electromagnetic field exposure with micro-
encapsulated thermo-chromic liquid crystal, IEICE technical report, 1-6, 2015.
8100C002 T.Masuoka, T.Ishibashi, M.Nishio:Biphasic modulation of noxious heat sensitivity in sensory neurons by peripheral
metabotropic glutamate receptors, Inflammation and Cell Signaling, 2:602, 2015.
8100C003 (K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.
8100C004 J.Yoshida, T.Ishibashi, T.Masuoka, N.Imaizumi, M.Nishio:Ca2+ Signalimg molecules STIM1/Orail and Cancer, Journal of Kanazawa Medical University, 40:2・3;69-77, 2015.
Presentations at Conference
International Conference (Presentations) 8100I001 M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees of
Obesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.
8100I002 SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.
8100I003 (Y.Suzuki), M.Sasaki, S.Onishi, R.Imai, M.Takamura, M.Taki, J.Chakarothai, K.Sasaki, K.Wake, S.Watanabe, M.Kojima, CY,Tsai, H.Sasaki:Acceleration of large-scale multi-physics simulation for biomedical EMC with many-
core architecture based computing, URSI AT-RASC, Canary Istands, 2015.
8100I004 Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd
International Symposium on Shiftwork and Working Time, Elsinore, 2015.
8100I005 (Y.Suzuki), M.Kojima, A.Kik, M.Taki:Non-destructive 3D temperature measurement for dosimetries of the thermal dose due to high frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal,
First PEM International Workshop in Kyoto, Kyoto, 2015.
128
Department of General Education
8610 Natural Sciences
Faculty
Title Name Field of Specialization Professor TANAKA Ichiro Scientific sociology, History of technology Professor MATSUDA Hiroo Lorentz manifolds, Curves in Euclidean space Associate Professor SHOJI Hiroki Developmental Biology, Molecular Biology, Biochemistry HASHIMOTO Associate Professor Radiation Biology, Cell Biology Mitsumasa Senior Assistant Professor ARIKAWA Tomohiro Immunology, Developmental Biology Senior Assistant Professor MAEDA Masayo Molecular oncology, Metastasis of Cancer Cells Senior Assistant Professor INOUE Tomoki Graph theory in toplogy Assistant Professor OKUDA Koichi Fixed-quantity rating system in the heart nuclear medicine
Keywords of Research
Bertrand curveMannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic fieldMannheim curve, Frenet frame, graph theory in topology, topological polyhedron, , Nuclear medicine Nuclear cardiology, Imaging, Image processingSPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing Radiation, DNA double strand breaks (DSBs), history of science, history of technologyGalileo GalileiIsaac NewtonVenetian patent law, , Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2), , ultrastructure, pharynxspongemetamorphosis, immunoelectron microscopy, neurosynapsneurosecretory cell, lectin, galectinβ-galactoside, Xenopusdevelopment, placenta
Outline of Research
１）Functional analysis of Galectins a family of ・-galactosides binding proteins. a）Roles of Galectins in animal development. b）Roles of Galectins in the placentation and immune tolerance. Hashimoto:Function of DNA repair enzymes especially protection mechanisms against DNA double strand breaks induced ionizing radiation especially protection mechanisms against DNA double strand breaks induced ionizing radiation Okuda:The aim of our research is to develop a computer algorithm for the quantitative assessment of myocardial perfusion and sympathetic nerve activity in the nuclear cardiology. MAEDA:Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies have indicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.Further investigation of the details of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to a better treatment for cancer. Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized Mannheim curve and examples of generalized Mannheim curve. Inoue:We extend the Graph Theory and define a topologicalpolyhedron which coverd on closed surface of genus g. We give characterizations and example of the topological polyhedron. TANAKA:The research theme is the history of early modern science and technology. The topics being studied include Galileo Galilei and Venetian Patent Law enacted in 15th century.
129 Publications
Originals 8610B001 (S.Matsuo), K.Nakajima, M.Onoguchi, H.Wakabayash, K.Okuda, S.Kinuya:Nuclear myocardial perfusion imaging using thallium-201 with a novel multifocal collimator SPECT/CT: IQ-SPECT versus conventional protocols in
normal subjects, Annals of Nuclear Medicine, 29:5;452-459, 2015.
8610B002 (K.Nakajima), S.Matsuo, H.Wakabayashi, H.Yokoyama, H.Bunko, K.Okuda, S.Kinuya, K.Nystrom, L.Edenbrandt:Diagnostic performance of artificial neural network for detecting ischemia in myocardial perfusion
imaging., Japanese Circulation Journal, 79:7;1549-1556, 2015.
8610B003 E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.
8610B004 T.Ota, M.Maeda, M.Okamoto, M.Tatsuka:Positive regulation of Rho GTPase activity by RhoGDIs as a result of
their direct interaction with GAPs, BMC Systems Biology, 9:3, 2015.
8610B005 (Y.Nonaka), T.Ogawa, H.Yoshida, H.Shoji, N.Nishi, S.Kamitori, T.Nakamura:Crystal structure of a Xenopus laevis
skin proto-type galectin, close to but distinct from galectin-1, Glycobiology, 25:7;792-803, 2015.
Presentations at Conference
International Conference (Presentations) 8610I001 (S.Kawahara), H.Masuda, D.Erickson, J.Moore, A.Suemitsu, Y.Shibuya.:Quantifying the effects of vowel quality and
preceding consonants on jaw displacement: Japanese data., Lexicon Festa-3, Tokyo, 2015.
8610I002 H. Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, M.Furukawa, S.Kinuya, T.Miwa:Prognostic value of olfactory nerve assessment with olfacto-scintigraphy in patients with olfactory disorders, The 37th annual meeting of the
Association for Chemoreception Sciences, Bonita Sorings, 2015.
8610I003 Y.Sunatani, M.K.Sharma, R.P.Kamdar, T.Matsui, R.Sakasai, M.Hashimoto, Y.Matsumoto, K.Iwabuchi: Phosphorylation-mediated Regulation of Apoptosis By NHEJ-protein XRCC4, 15th International Congress of
Radiation Research, Kyoto, 2015.
8610I004 R.Sakasai, Y.Sunatani, T.Matsui, M.Hashimoto, K.Iwabuchi:Ubiquitin-dependent Activation of DNA-PKcs Leads to Chromosomal Aberration in Response to One-ended DNA Double Strand Breaks, 15th International Congress of
Radiation Research, Kyoto, 2015.
8610I005 K.Okuda, K.Nakajima, Y.Kirihara, S.Sugino, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya:Standardization of cardiac I-123 metaiodobenzylguanidine washout rates derivedfrom late 3 and 4 hours imaging, ICNC12,Nuclear Cardiology
and Cardiac CT., Madrid, 2015.
8610I006 K.Okuda, N.Nakajima, K.Nystrom, L.Edenbrandt, S.Matsuo, H.Wakabayashi, M.Hashimoto, S.Kinuya:Comparison of two software packages for the evaluation of the left ventricular dyssynchrony by phase analysis in gated
myocardial perfusion SPECT, ICNC 12,Nuclear Cardiology and Cardiac CT, Madrid, 2015.
130 8620 Human Sciences
Faculty
Title Name Field of Specialization Professor SHIBUYA Yoshiho English linguistics, Phonetics Professor HARA Akira Austria literature led by Hofmannsthal Associate Professor KOCHI Munehiro Interpretationen von Goethes Werken, Begriff von Bildung Senior Assistant Professor HONDA Kojiro Ethics of technology Senior Assistant Professor KIKUCHI Takeshi Senior Assistant Professor IKENAKA Masami English Education Senior Assistant Professor CRAIG Woods English, Medical English BURKE STEVEN Senior Assistant Professor English Thomas Senior Assistant Professor TSUDA Ryosuke Exercise physiology, Pedagogy of physical education
Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 researchlanguage acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration, suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical Englishe- learning, , logic, metaphysics, form, content, predicate, category, deduction, induction, matterbeing, substance, definion, Phenomenology, Philosophy of Technology, Ethics of Technology, Engineering Ethics, Robo-ethics, Medical Ethics, Cognitive Science of Learning, History of Science, Philosophy of Science, , exercise prescription, lifestyle-related diseases, improvement of physical fitness, soccer, PE class, , end of the century, culture, the middle Ages, Modern times, Europe,
Outline of Research
Hara : In the German-language area from the end of the 19th century to the beginning of the 20th century many prominent intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the German- language area and furthermore in all Europe many prominent intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna but his influence reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the German-language area and furthermore in all Europe. Kouchi : Das Europa im zweiten Halfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen mittelalterlichnen Denkweise zur neuen modernen wie sie der Historiker Reinharｔ Kosellecｋ die “Sattelzeit“ nennt. Wie man sich damals mit dem Wechsel des Paradigmas auseinander setzte mochte ich im Fall vom deutschen Dichter Goethe untersuchen und in seinen Werken wie Romanen und Dramen zeigen mochte ich im Fall vom deutschen Dichter Goethe untersuchen und in seinen Werken wie Romanen und Dramen zeigen Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition our research focuses on improvement of physical fitness through soccer in PE classes for children. Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here Japanese) influence the pronunciation of Japanese speakers of English is studied, Japanese) influence the pronunciation of Japanese speakers of English is studied. Burke:My most recent research interest has been the connection and power that extensive reading has on English acquisition for EFL students.
131 Woods:Using computer software for natural language processing of the English found in medical articles to determine the most commonly used words forms and structures. Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students. HONDA:It is inquiring about the ethics of technology. Tradition of knowledge" has considered the problem what kind of responsibility occurs why in possible one and the side which inherits knowledge again by the mainly phenomenological technique.
Presentations at Conference
International Conference (Presentations) 8620I001 (S.Kawahara), H.Masuda, D.Erickson, J.Moore, A.Suemitsu, Y.Shibuya.:Quantifying the effects of vowel quality and
preceding consonants on jaw displacement: Japanese data., Lexicon Festa-3, Tokyo, 2015.
8620I002 (R.Iwata), D.Erickson, Y.Shibuya, A.Suemitsu:Articulation of phrasal stress in Mandarin Chinese., Proceedings of
Acoustical Society of Japan, fall meeting, Tokyo, 2015.
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Affiliated Institution
9030 Northern Noto Institute for Community Medicine
Faculty
Title Name Field of Specialization Professor NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology
Keywords of Research
The Elderly, Rural Medicine, Medical Needs,
Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.
133 9050 FDD-MB Center
Faculty
Title Name Field of Specialization Director TAKABAYASHI Haruo fetal medicine, DNA medicine.
Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array, Lab on a Chip,
Outline of Research
Mission of Center for FDD-MB 1. elucidation of the relationship between fetal cells and mother's health 2. development of fetal DNA diagnosis from maternal blood (FDD-MB) 3. development of single cell technology
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Himi Municipal Hospital 9100 Himi Municipal Hospital
Faculty
Title Name Field of Specialization Director SAITO Hitoshi Surgical treatment of hepatobiliary and pancreatic disease Professor FUKUDA Akihiro Cardiology Professor SAKAMOTO Shigeru Cardiovascular Surgery Professor MORIYAMA Manabu Kidney transplantation，Urolithiasis Professor HATASHIMA Sunao Anesthesiology/Resuscitation studies Professor MATSUKI Nobuo Oncology Surgery Associate Professor ITO Tomohiko adrenal diseases, diabetes, thyroid diseases Associate Professor IGUCHI Masaharu Respiratory Medicine Associate Professor KUGINUKI Yasuaki Medical Radiography Associate Professor IKEBUCHI Kimihiro Orthopaedic Surgery Associate Professor MATSUNO Hideo Allergy，Otorhinolaryngology Associate Professor MATSUI Toshiaki Oral & Maxilofacial Surgery Senior Assistant Professor KIYOSAWA Jun Cardiology Senior Assistant Professor SAITO Atsushi Nephrology Senior Assistant Professor AOKI Nobuyuki Orthopaedic Surgery Senior Assistant Professor OHURA Kazuko Otorhinolaryngology Senior Assistant Professor KAWASAKI Masanori Anesthesiology/Resuscitation studies Assistant Professor MIZUNO Takuro Cardiology HIGASHIKAWA Assistant Professor Gerontology Toshihiro Assistant Professor ISHIGAMI Keiichiro Gerontology Assistant Professor MUKAI Hirokado Oncology Surgery Assistant Professor HAYASHI Kei Oncology Surgery Assistant Professor NAKAMURA Kisuke Oncology Surgery Assistant Professor SAKAMOTO Daisuke Cardiovascular Surgery Assistant Professor KUSABA Eizo neurosurgery
Publications
Originals 9100B001 T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda, S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.
9100B002 S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya:Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney International., 88:3;479-489,
2015.
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Reviews 9100C001 T.Nagai, K.Nitta, M.Kanasaki, D.Koya, K.Kanasaki:The biological significance of angiotensin-converting enzyme
inhibition to combat kidney fibrosis, Clinical and Experimental Nephrology, 19:1;65-74, 2015.
Presentations at Conference
International Conference (Presentations) 9100I001 S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Factors related to catheter blockage in home
nursing care patients with long-term indwelling catheters, 16th international EAUN meeting, Madrid, 2015.
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