Kanazawa Medical University Research Activities and Publications VOL.27 2015 Kanazawa Medical University I N D E X Code Depaertment Page Code Depaertment Page Basic Medical Science 0100 Department of Anatomy Ⅰ ・・・・・・・・ 1 0460 Department of Pediatric Surgery ・・・・・・・・ 70 0110 Department of Anatomy Ⅱ ・・・・・・・・ 2 0470 Department of Ophthalmology ・・・・・・・・ 72 0120 Department of Physiology Ⅰ ・・・・・・・・ 3 0475 Department of Otorhinolaryngology ・・・・・・・・ 76 0130 Department of Physiology Ⅱ ・・・・・・・・ 5 0485 Department of Head and Neck Surgery ・・・・・・・・ 78 0140 Department of Biochemistry Ⅰ ・・・・・・・・ 7 0490 Department of Dermatology ・・・・・・・・ 79 0150 Department of Biochemistry Ⅱ ・・・・・・・・ 8 0500 Department of Urology ・・・・・・・・ 81 0160 Department of Pharmacology ・・・・・・・・ 9 0510 Department of Obstetrics and Gynecology ・・・・・・・・ 83 0170 Department of Pathology Ⅰ ・・・・・・・・ 11 0520 Department of Anesthesiology and 0180 Department of Pathology Ⅱ ・・・・・・・・ 13 Perioperative Medicine ・・・・・・・・ 85 0190 Department of Microbiology ・・・・・・・・ 15 0540 Department of Physical and Rehabilitation 0200 Department of Immunology ・・・・・・・・ 16 Medicine ・・・・・・・・ 87 0210 Department of Medical Zoology ・・・・・・・・ 17 0550 Department of Emergency Medicine ・・・・・・・・ 88 0220 Department of Pathology and Laboratory 0570 Department of Community Medicine ・・・・・・・・ 89 edicine ・・・・・・・・ 18 0575 Department of Gastroenterological Endoscopy ・・・・・・・・ 90 0230 Department of Social and Environmental 0580 Department of Oral and Maxillofacial Surgery ・・・・・・・・ 92 Medicine ・・・・・・・・ 20 0240 Department of Epidemiology and Public Heaｌｔｈ ・・・・・・・・ 21 University Hospital 0250 Department of Legal Medicine ・・・・・・・・ 24 0635 Hepatology ・・・・・・・・93 0260 Department of Medical Education ・・・・・・・・ 25 0675 Health Evaluation Center ・・・・・・・・ 95 Clinical Medicine Medical Research Institute 0300 Department of Cardiology ・・・・・・・・ 26 7100 Department of Life Science ・・・・・・・・ 98 0310 Department of Respiratory Medicine ・・・・・・・・ 28 7200 Department of Advanced Medicine ・・・・・・・・ 102 0320 Department of Gastroenterology ・・・・・・・・ 30 7310 Division of Innovative Research ・・・・・・・・ 106 0330 Department of Nephrology ・・・・・・・・ 32 7320 Division of Vision Research for Environmental 0340 Department of Diabetology and Endocrinology ・・・・・・・・ 35 Health ・・・・・・・・ 108 0350 Department of Hematology and Immunology ・・・・・・・・ 38 7340 Division of Anticipatory Molecular Food Science 0360 Department of Neurology ・・・・・・・・ 41 and echnology ・・・・・・・・ 112 0363 Department of Medical Oncology ・・・・・・・・ 44 7350 Division of Systems Bioscience for Drug 0366 Department of Infectious Diseases ・・・・・・・・ 46 Discovery Based on Intrinsically Disordered 0368 Department of General Internal Medicine ・・・・・・・・ 47 Proteins ・・・・・・・・ 113 0370 Department of Geriatric Medicine ・・・・・・・・ 49 7400 Research Support Cente ・・・・・・・・ 115 0380 Department of Pediatrics ・・・・・・・・ 50 0390 Department of Neuropsychiatry ・・・・・・・・ 52 School of Nursing 0400 Department of Radiology ・・・・・・・・ 54 8010 Fundamental Nursing ・・・・・・・・ 118 0410 Department of Cardiovascular Surgery ・・・・・・・・ 56 8040 Adult Nursing ・・・・・・・・ 120 0415 Department of Thoracic Surgery ・・・・・・・・ 57 8050 Gerontological Nursing ・・・・・・・・ 121 0420 Department of General and Digestive Surgery ・・・・・・・・ 59 8060 Pediatric Nursing ・・・・・・・・ 122 0430 Department of Orthopedics Surgery ・・・・・・・・ 62 8070 Maternity Nursing・Midwifery ・・・・・・・・ 123 0440 Department of Neurosurgery ・・・・・・・・ 65 8080 Public Health Nursing ・・・・・・・・ 124 0450 Department of Plastic and Reconstructive 8085 Psychiatric and Mental Health Nursing ・・・・・・・・ 125 Surgery ・・・・・・・・ 68 8090 Home Care Nursing ・・・・・・・・ 126 8100 Medical Science ・・・・・・・・ 127 Code Depaertment Page Code Depaertment Page Department of General Education 8610 Natural Science ・・・・・・・・ 129 8620 Human Science ・・・・・・・・ 131 Affiliated Institution 9030 Northern Noto Institute of Community Medicine ・・・・・・・・ 133 9050 FDD-MB Center ・・・・・・・・ 134 Himi Municipal Hospital 9100 Himi Municipal Hospital ・・・・・・・・ 135 Basic Medical Science 0100 Department of Anatomy Ⅰ Faculty Title Name Field of Specialization Professor HATTA Toshihisa developmental biology, neuroscience Professor HIGASHI Nobuaki macroscopic anatomy, embryology Senior Assistant Professor SHIMADA Hiroki Medical science of free radical Keywords of Research exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant, apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry, human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide, scavenger, VDAC, anomaly of muscles and blood vessels Outline of Research 1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine network. 2. Cytochemical study of the cytotoxicity by reactive oxygen species. 3. Biological functions of VDAC family proteins. 4. Macroscopic studies on the variations of muscles and blodd vessels. 5. Comparative anatomical studies on the brain evolution Publications Originals 0100B001 (N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki:Three-dimensional structure of seminiferous tubules in the adult mouse, Journal of Anatomy, 227:5;686-694, 2015. 0100B002 E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015. 0100B003 T.Tsukada, E.Simamura, H.Shimada, T.Arai, N.Higashi, T.Akai T, H.Iizuka, T.Hatta:The suppression of maternal- fetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in mice, PLoS One, 10:6;e0129011, 2015. 1 0110 Department of Anatomy Ⅱ Faculty Title Name Field of Specialization Professor HONMA Satoru gross anatomy Neuroanatomy, immunohistochemistry, electron microscopy, 3D Senior Assistant Professor SONOMURA Takahiro reconstruction immunocytochemistry, pituitary, cell proliferation, electron Senior Assistant Professor KOMINAMI Rieko microscopy Senior Assistant Professor YASUTAKA Satoru gross anatomy, central nervous system Keywords of Research arthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH, GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA, Neuroanatomy, FIB/SEM, BMI, gustatory, Outline of Research Theme of researches 1)Human gross anatomy 2)Neural network of the basal ganglia 3）Circuit of gustatory in the central nervous system 4）Anatomical study of brain white matter by using fiber dissection technique 5）Immuno-histochemical study of pituitary gland Publications Originals 0110B001 (N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki:Three-dimensional structure of seminiferous tubules in the adult mouse, Journal of Anatomy, 227:5;686-694, 2015. 0110B002 (T.Tsukahara), M.Masuhara, H.Iwai, T.Sonomura, T.Sato:Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female mice, Biochemical and Biophysical Research Communications, 465:1;145-151, 2015. 0110B003 (H.Iwai), E.Kuramoto, A.Yamanaka, T.Sonomura, M.Uemura, T.Goto:Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions., Neuroscience, 294:1-13, 2015. 2 0120 Department of Physiology Ⅰ Faculty Title Name Field of Specialization Professor KATO Nobuo Brain Science Senior Assistant Professor TAJIMA Nobuyoshi molecular physiology Assistant Professor UCHIUMI Osamu Neuroscience Keywords of Research central nervous system, neurophysiology, electrophysiology, immunohistochemistry, field potential, propagating signal, horizontal propagation, oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording, intracellular staining, Neuroethology, Behavioral test battery, BK channel Outline of Research The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not a mere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellular messenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. Publications Originals 0120B001 Y.Zhang, F.Wang, X.Luo, L.Wang, P.Sun, M.Wang, Y.Jiang, J.Zou, O.Uchiumi, R.Yamamoto, T.Sugai, K.Yamamoto, N.Kato:Cognitive improvement by photic stimulation in a mouse model of Alzheimer's disease, Current Alzheimer Research, 12:9;860-869, 2015. 0120B002 P.Sun, Q.Zhang, Y.Zhang, F.Wang, L.Wang, R.Yamamoto, T.Sugai, N.Kato:Fear conditioning suppresses large- conductance calcium-activated potassium channels in lateral amygdala neurons., Physiology & Behavior, 138:279- 284, 2015. 0120B003 L.Wang, H.Kang, Y.Li, Y.Shui, R.Yamamoto, T.Sugai, N.Kato:Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel